[{"id":"SEQ_00007","a":"P26651","g":"ZFP36","d":"mRNA decay activator protein ZFP36","L":326,"m":[{"c":"+YKTELC[RH]xFxxoGRCxYG[AS]+CxFφH","u":26,"sp":"periodic","x":"structured_like","cf":"high","why":"Two strongly conserved 26-residue repeats separated by a 12-aa linker, sharing 16 identical positions including a C-x8-C-x5-C-x3-H cysteine/histidine spacing, aromatic anchors (Y, F, Y, F), and an N-terminal +YKTELC motif.","i":[[103,128,"RYKTELCRTFSESGRCRYGAKCQFAH"],[141,166,"KYKTELCHKFYLQGRCPYGSRCHFIH"]]},{"c":"PPPPGxφ[PG][LP]","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 9-residue motifs located in the N- and C-terminal proline/serine-rich disordered regions, anchored by an invariant PPPPG core followed by a conserved hydrophobic residue (A/L) and P/G/L C-terminal positions.","i":[[71,79,"PPPPGFAPL"],[198,206,"PPPPGLAGP"],[219,227,"PPPPGDLPL"]]}],"s":"MDLTAIYESLLSLSPDVPVPSDHGGTESSPGWGSSGPWSLSPSDSSPSGVTSRLPGRSTSLVEGRSCGWVPPPPGFAPLAPRLGPELSPSPTSPTATSTTPSRYKTELCRTFSESGRCRYGAKCQFAHGLGELRQANRHPKYKTELCHKFYLQGRCPYGSRCHFIHNPSEDLAAPGHPPVLRQSISFSGLPSGRRTSPPPPGLAGPSLSSSSFSPSSSPPPPGDLPLSPSAFSAAPGTPLARRDPTPVCCPSCRRATPISVWGPLGGLVRTPSVQSLGSDPDEYASSGSSLGGSDSPVFEAGVFAPPQPVAAPRRLPIFNRISVSE"},{"id":"SEQ_00019","a":"Q8WVS4","g":"DYNC2I1","d":"Cytoplasmic dynein 2 intermediate chain 1","L":1066,"m":[{"c":"xxxxxxx[SL]P(x){4,13}xxxxxxxxxψxx[WH]xxx","u":"29-38","sp":"dispersed","x":"structured_like","cf":"high","why":"Six beta-propeller-like repeats in the C-terminal structured region anchored by an N-terminal [SL]P turn motif, hydrophobic beta-strands, and a conserved C-terminal ψxx[WH] core separated by variable inter-blade linkers.","i":[[656,684,"MVVSVHDLPEKSFVPLLDSKYVLCVWDIW"],[698,727,"QVTCCCLSPLKAFLLFAGTAHGSVVVWDLR"],[777,814,"KKQSFVLSPFSTQEEMSGLSFHIASLDESGVLNVWVVV"],[862,890,"QTLNVKFLPSDPNHFIIGTDMGLISHGTR"],[911,940,"KVNVIDFSPFGEPIFLAGCSDGSIRLHQLS"],[956,985,"AVTGLQWSPTRPAVFLVQDDTSNIYIWDLL"]]}],"s":"MEPGKRRTKDDTWKADDLRKHLWAIQSGGSKEERKHREKKLRKESEMDLPEHKEPRCRDPDQDARSRDRVAEVHTAKESPRGERDRDRQRERRRDAKDREKEKLKEKHREAEKSHSRGKDREKEKDRRARKEELRQTVAHHNLLGQETRDRQLLERAERKGRSVSKVRSEEKDEDSERGDEDRERRYRERKLQYGDSKDNPLKYWLYKEEGERRHRKPREPDRDNKHREKSSTREKREKYSKEKSNSFSDKGEERHKEKRHKEGFHFDDERHQSNVDRKEKSAKDEPRKRESQNGEHRNRGASSKRDGTSSQHAENLVRNHGKDKDSRRKHGHEEGSSVWWKLDQRPGGEETVEIEKEETDLENARADAYTASCEDDFEDYEDDFEVCDGDDDESSNEPESREKLEELPLAQKKEIQEIQRAINAENERIGELSLKLFQKRGRTEFEKEPRTDTNSSPSRASVCGIFVDFASASHRQKSRTQALKQKMRSTKLLRLIDLDFSFTFSLLDLPPVNEYDMYIRNFGKKNTKQAYVQCNEDNVERDIQTEEIETREVWTQHPGESTVVSGGSEQRDTSDAVVMPKIDTPRLCSFLRAACQVMAVLLEEDRLAAEPSWNLRAQDRALYFSDSSSQLNTSLPFLQNRKVSSLHTSRVQRQMVVSVHDLPEKSFVPLLDSKYVLCVWDIWQPSGPQKVLICESQVTCCCLSPLKAFLLFAGTAHGSVVVWDLREDSRLHYSVTLSDGFWTFRTATFSTDGILTSVNHRSPLQAVEPISTSVHKKQSFVLSPFSTQEEMSGLSFHIASLDESGVLNVWVVVELPKADIAGSISDLGLMPGGRVKLVHSALIQLGDSLSHKGNEFWGTTQTLNVKFLPSDPNHFIIGTDMGLISHGTRQDLRVAPKLFKPQQHGIRPVKVNVIDFSPFGEPIFLAGCSDGSIRLHQLSSAFPLLQWDSSTDSHAVTGLQWSPTRPAVFLVQDDTSNIYIWDLLQSDLGPVAKQQVSPNRLVAMAAVGEPEKAGGSFLALVLARASGSIDIQHLKRRWAAPEVDECNRLRLLLQEALWPEGKLHK"},{"id":"SEQ_00032","a":"Q9UHD8","g":"SEPTIN9","d":"Septin-9","L":586,"m":[{"c":"+R[VTA]Eψ","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five dispersed copies of a strongly conserved 5-residue motif in the N-terminal P/S/E/A-enriched disordered region (residues 90-190), anchored by a dibasic +R dyad, invariant E at position 4, constrained [VTA] at position 3, and large aliphatic ψ at position 5.","i":[[91,95,"RRVEL"],[106,110,"RRTEL"],[133,137,"KRAEV"],[148,152,"RRTEI"],[186,190,"KRVEI"]]}],"s":"MKKSYSGGTRTSSGRLRRLGDSSGPALKRSFEVEEVETPNSTPPRRVQTPLLRATVASSTQKFQDLGVKNSEPSARHVDSLSQRSPKASLRRVELSGPKAAEPVSRRTELSIDISSKQVENAGAIGPSRFGLKRAEVLGHKTPEPAPRRTEITIVKPQESAHRRMEPPASKVPEVPTAPATDAAPKRVEIQMPKPAEAPTAPSPAQTLENSEPAPVSQLQSRLEPKPQPPVAEATPRSQEATEAAPSCVGDMADTPRDAGLKQAPASRNEKAPVDFGYVGIDSILEQMRRKAMKQGFEFNIMVVGQSGLGKSTLINTLFKSKISRKSVQPTSEERIPKTIEIKSITHDIEEKGVRMKLTVIDTPGFGDHINNENCWQPIMKFINDQYEKYLQEEVNINRKKRIPDTRVHCCLYFIPATGHSLRPLDIEFMKRLSKVVNIVPVIAKADTLTLEERVHFKQRITADLLSNGIDVYPQKEFDEDSEDRLVNEKFREMIPFAVVGSDHEYQVNGKRILGRKTKWGTIEVENTTHCEFAYLRDLLIRTHMQNIKDITSSIHFEAYRVKRLNEGSSAMANGMEEKEPEAPEM"},{"id":"SEQ_00034","a":"Q9UKT9","g":"IKZF3","d":"Zinc finger protein Aiolos","L":509,"m":[{"c":"[FYM]xCxxCxxxxxxxxx[LF]xxH(x){3,5}[HC]","u":"23-25","sp":"dispersed","x":"structured_like","cf":"high","why":"Six conserved CxxC...Hxxx[HC] repeat units anchored by an N-terminal hydrophobic/aromatic residue ([FYM]), an invariant CxxC pair, a conserved internal [LF] position, and a C-terminal H(x){3,5}[HC] pair, arranged in an N-terminal cluster of four copies and a C-terminal cluster of two copies separated by 5-aa linkers within each cluster.","i":[[118,140,"MNCDVCGLSCISFNVLMVHKRSH"],[146,168,"FQCNQCGASFTQKGNLLRHIKLH"],[174,196,"FKCHLCNYACQRRDALTGHLRTH"],[202,224,"YKCEFCGRSYKQRSSLEEHKERC"],[452,474,"YRCDHCRVLFLDYVMFTIHMGCH"],[480,504,"FECNMCGYRSHDRYEFSSHIARGEH"]]}],"s":"MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDDSMKVKDEYSERDENVLKSEPMGNAEEPEIPYSYSREYNEYENIKLERHVVSFDSSRPTSGKMNCDVCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHTGEKPFKCHLCNYACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLEEHKERCRTFLQSTDPGDTASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQNHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYEFSSHIARGEHRALLK"},{"id":"SEQ_00037","a":"Q8WXS8","g":"ADAMTS14","d":"A disintegrin and metalloproteinase with thrombospondin motifs 14","L":1223,"m":[{"c":"W(x){2,4}W(x){2,5}CSx[AST]CG(x){1,2}G[VI][QR]xxxxxC(x){9,16}C(x){9,12}CxxxxC","u":"50-58","sp":"dispersed","x":"structured_like","cf":"high","why":"Four 50-58 aa cysteine-rich repeats (one isolated N-terminal copy and three tandem C-terminal copies separated by 3-4 aa linkers) anchored by an N-terminal W-x(2,4)-W pair, a conserved CSx[AST]CG(x){1,2}G[VI][QR] core, and six strictly conserved cysteines ending in a fixed CxxxxC motif.","i":[[555,606,"WSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEEC"],[851,906,"WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC"],[911,968,"WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPC"],[972,1021,"WRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPAC"]]}],"s":"MAPLRALLSYLLPLHCALCAAAGSRTPELHLSGKLSDYGVTVPCSTDFRGRFLSHVVSGPAAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPSGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPGYHRLCCVSCIKKASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQTPTPVPEDKGQPGEDLRHPGTSLPAASPVT"},{"id":"SEQ_00041","a":"P78347","g":"GTF2I","d":"General transcription factor II-I","L":998,"m":[{"c":"L+xxVxxφFxx[KC]x[AG]xA[LI][GK]xxxx[VK]x[VI]P[YF]xxφxxxxxxφ[VY]V[EDQ]G[LM]P[EP][GN][IV]xF+xP[STE]xφ[GDE][IL]xx[LM]xxIψxxxxxI[KRS]Fx[IV][KI]+[PH][EF]","u":77,"sp":"dispersed","x":"structured_like","cf":"high","why":"Six gapless 77-residue structured domain repeats separated by variable disordered linkers (28-171 aa), anchored by invariant L(1), V(5), F(9), A(16), P(26), V(39), G[LM]P(41-43), F+(48-49), P(51), Iψ(62-63), I(69), and F(71) positions across all six copies.","i":[[112,188,"LRKTVEDYFCFCYGKALGKSTVVPVPYEKMLRDQSAVVVQGLPEGVAFKHPENYDLATLKWILENKAGISFIIKRPF"],[361,437,"LRKQVEELFERKYAQAIKAKGPVTIPYPLFQSHVEDLYVEGLPEGIPFRRPSTYGIPRLERILLAKERIRFVIKKHE"],[466,542,"LRKMVDQLFCKKFAEALGSTEAKAVPYQKFEAHPNDLYVEGLPENIPFRSPSWYGIPRLEKIIQVGNRIKFVIKRPE"],[571,647,"LRKQVEEIFNLKFAQALGLTEAVKVPYPVFESNPEFLYVEGLPEGIPFRSPTWFGIPRLERIVRGSNKIKFVVKKPE"],[733,809,"LKQKVENLFNEKCGEALGLKQAVKVPFALFESFPEDFYVEGLPEGVPFRRPSTFGIPRLEKILRNKAKIKFIIKKPE"],[868,944,"LREQVNDLFSRKFGEAIGMGFPVKVPYRKITINPGCVVVDGMPPGVSFKAPSYLEISSMRRILDSAEFIKFTVIRPF"]]}],"s":"MAQVAMSTLPVEDEESSESRMVVTFLMSALESMCKELAKSKAEVACIAVYETDVFVVGTERGRAFVNTRKDFQKDFVKYCVEEEEKAAEMHKMKSTTQANRMSVDAVEIETLRKTVEDYFCFCYGKALGKSTVVPVPYEKMLRDQSAVVVQGLPEGVAFKHPENYDLATLKWILENKAGISFIIKRPFLEPKKHVGGRVMVTDADRSILSPGGSCGPIKVKTEPTEDSGISLEMAAVTVKEESEDPDYYQYNIQAGPSETDDVDEKQPLSKPLQGSHHSSEGNEGTEMEVPAEDSTQHVPSETSEDPEVEVTIEDDDYSPPSKRPKANELPQPPVPEPANAGKRKVREFNFEKWNARITDLRKQVEELFERKYAQAIKAKGPVTIPYPLFQSHVEDLYVEGLPEGIPFRRPSTYGIPRLERILLAKERIRFVIKKHELLNSTREDLQLDKPASGVKEEWYARITKLRKMVDQLFCKKFAEALGSTEAKAVPYQKFEAHPNDLYVEGLPENIPFRSPSWYGIPRLEKIIQVGNRIKFVIKRPELLTHSTTEVTQPRTNTPVKEDWNVRITKLRKQVEEIFNLKFAQALGLTEAVKVPYPVFESNPEFLYVEGLPEGIPFRSPTWFGIPRLERIVRGSNKIKFVVKKPELVISYLPPGMASKINTKALQSPKRPRSPGSNSKVPEIEVTVEGPNNNNPQTSAVRTPTQTNGSNVPFKPRGREFSFEAWNAKITDLKQKVENLFNEKCGEALGLKQAVKVPFALFESFPEDFYVEGLPEGVPFRRPSTFGIPRLEKILRNKAKIKFIIKKPEMFETAIKESTSSKSPPRKINSSPNVNTTASGVEDLNIIQVTIPDDDNERLSKVEKARQLREQVNDLFSRKFGEAIGMGFPVKVPYRKITINPGCVVVDGMPPGVSFKAPSYLEISSMRRILDSAEFIKFTVIRPFPGLVINNQLVDQSESEGPVIQESAEPSQLEVPATEEIKETDGSSQIKQEPDPTW"},{"id":"SEQ_00043","a":"P16112","g":"ACAN","d":"Aggrecan core protein","L":2530,"m":[{"c":"[GER]LPSG(x){0,1}Ex[LV][EV][TIG][ATS][ATV][PS][GAE]xx(x){0,1}-ψ[SG]","u":"19-21","sp":"tandem","x":"disordered_like","cf":"high","why":"35 head-to-tail tandem copies spanning 672 residues in the central disordered region, dominated by a highly conserved 19-aa core (GLPSGEVLET[AT]APGVEDIS) with invariant LPSG, E, acidic (-), and aliphatic (ψ) anchors.","i":[[936,955,"ELPSGAEILEGSASGVGDLS"],[956,974,"GLPSGEVLETSASGVGDLS"],[975,993,"GLPSGEVLETTAPGVEDIS"],[994,1012,"GLPSGEVLETTAPGVEDIS"],[1013,1031,"GLPSGEVLETTAPGVEDIS"],[1032,1050,"GLPSGEVLETTAPGVEDIS"],[1051,1069,"GLPSGEVLETTAPGVEDIS"],[1070,1088,"GLPSGEVLETTAPGVEDIS"],[1089,1107,"GLPSGEVLETAAPGVEDIS"],[1108,1126,"GLPSGEVLETAAPGVEDIS"],[1127,1145,"GLPSGEVLETAAPGVEDIS"],[1146,1164,"GLPSGEVLETAAPGVEDIS"],[1165,1183,"GLPSGEVLETAAPGVEDIS"],[1184,1202,"GLPSGEVLETAAPGVEDIS"],[1203,1221,"GLPSGEVLETAAPGVEDIS"],[1222,1240,"GLPSGEVLETAAPGVEDIS"],[1241,1259,"GLPSGEVLETAAPGVEDIS"],[1260,1278,"GLPSGEVLETAAPGVEDIS"],[1279,1297,"GLPSGEVLETAAPGVEDIS"],[1298,1316,"GLPSGEVLETAAPGVEDIS"],[1317,1335,"GLPSGEVLETAAPGVEDIS"],[1336,1354,"GLPSGEVLETAAPGVEDIS"],[1355,1373,"GLPSGEVLETAAPGVEDIS"],[1374,1392,"GLPSGEVLETAAPGVEDIS"],[1393,1411,"GLPSGEVLETTAPGVEEIS"],[1412,1430,"GLPSGEVLETTAPGVDEIS"],[1431,1449,"GLPSGEVLETTAPGVEEIS"],[1450,1468,"GLPSGEVLETSTSAVGDLS"],[1469,1488,"GLPSGGEVLEISVSGVEDIS"],[1489,1507,"GLPSGEVVETSASGIEDVS"],[1508,1526,"ELPSGEGLETSASGVEDLS"],[1527,1546,"RLPSGEEVLEISASGFGDLS"],[1547,1567,"GLPSGGEGLETSASEVGTDLS"],[1568,1587,"GLPSGREGLETSASGAEDLS"],[1588,1607,"GLPSGKEDLVGSASGDLDLG"]]},{"c":"G[IVE]VF[HYF](x){4,7}xx[LF][TD]F[DEQ][RE]AxxxCxxxxxxψA[TS][PT][EG]QL[QY]φAΩxxGφxxC[DSY]AGWL[AR]D[QRG][TS]ψRYPIx[TSK][PA]RxxC[YVG]G(x){3,6}GVRT[YV][GY](x){7,14}[YH][DH][VA]φC[FY]x","u":"97-98","sp":"dispersed","x":"structured_like","cf":"high","why":"Four homologous 97-98 aa globular domain repeats arranged as two closely spaced pairs in the N-terminal half, anchored by four invariant cysteines and signature G[IVE]VF, A[TS][PT][EG]QL, AGWL[AR]DxxψRYPI, and GVRT motifs.","i":[[152,248,"GIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFA"],[253,350,"GEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYT"],[477,573,"GVVFHYRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFV"],[578,675,"GEVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFR"]]},{"c":"xx[SPF]GxxxxSG","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"18 copies of a 10-residue disordered motif occurring in contiguous tandem blocks separated by variable linkers in the C-terminal IDR, defined by fixed G4 and S9-G10 anchors and strong enrichment for P at positions 2/6, D/E/G at position 7, and hydrophobics at position 8.","i":[[1642,1651,"PPSGLPDFSG"],[1718,1727,"QASGSPDVSG"],[1728,1737,"EIPGLFGVSG"],[1738,1747,"QPSGFPDTSG"],[1748,1757,"ETSGVTELSG"],[1758,1767,"LSSGQPGISG"],[1778,1787,"QPFGITDLSG"],[1788,1797,"ETSGVPDLSG"],[1798,1807,"QPSGLPGFSG"],[1858,1867,"LPSGEADLSG"],[1877,1886,"QFSGTVDSSG"],[1897,1906,"LPSGIAEVSG"],[1917,1926,"LPSGAYYGSG"],[1957,1966,"GPSGILELSG"],[1967,1976,"AHSGAPDMSG"],[1977,1986,"EHSGFLDLSG"],[1987,1996,"LQSGLIEPSG"],[1997,2006,"EPPGTPYFSG"]]},{"c":"[EVR][PL][SF][PA]S[EVK]","u":6,"sp":"tandem","x":"disordered_like","cf":"high","why":"Ten contiguous head-to-tail 6-aa repeats in a proline/serine-rich linker region, tightly constrained at every position including an alternating S/F choice at position 3, [PA] at position 4, and invariant S at position 5.","i":[[780,785,"VPSASE"],[786,791,"EPSPSE"],[792,797,"VPFPSE"],[798,803,"EPSPSE"],[804,809,"EPFPSV"],[810,815,"RPFPSV"],[816,821,"ELFPSE"],[822,827,"EPFPSK"],[828,833,"EPSPSE"],[834,839,"EPSASE"]]},{"c":"[FL]P[TE]V[ST]L[VI][DT][SR][TE][LF]VE[VSG]VTxx[TP][TI][AS][EQ]xxG","u":25,"sp":"dispersed","x":"mixed","cf":"high","why":"Three dispersed 25-aa gapless repeats embedded between the 10-mer blocks of the C-terminal region, sharing eight invariant anchors (P2, V4, L6, V12, E13, V15, T16, G25) and conserved aliphatic/polar positions.","i":[[1656,1680,"FPTVSLVDSTLVEVVTASTASELEG"],[1931,1955,"FPTVSLVDRTLVESVTQAPTAQEAG"],[2031,2055,"LPEVTLITSEFVEGVTEPTISQELG"]]}],"s":"MTTLLWVFVTLRVITAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPSDATLEVQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITVQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLEPEEPFTFAPEIGATAFAEVENETGEATRPWGFPTPGLGPATAFTSEDLVVQVTAVPGQPHLPGGVVFHYRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISAVPSPGEEEGGTPTSPSGVEEWIVTQVVPGVAAVPVEEETTAVPSGETTAILEFTTEPENQTEWEPAYTPVGTSPLPGILPTWPPTGAATEESTEGPSATEVPSASEEPSPSEVPFPSEEPSPSEEPFPSVRPFPSVELFPSEEPFPSKEPSPSEEPSASEEPYTPSPPVPSWTELPSSGEESGAPDVSGDFTGSGDVSGHLDFSGQLSGDRASGLPSGDLDSSGLTSTVGSGLPVESGLPSGDEERIEWPSTPTVGELPSGAEILEGSASGVGDLSGLPSGEVLETSASGVGDLSGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETTAPGVEEISGLPSGEVLETTAPGVDEISGLPSGEVLETTAPGVEEISGLPSGEVLETSTSAVGDLSGLPSGGEVLEISVSGVEDISGLPSGEVVETSASGIEDVSELPSGEGLETSASGVEDLSRLPSGEEVLEISASGFGDLSGLPSGGEGLETSASEVGTDLSGLPSGREGLETSASGAEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPETSGLPSGFSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSLVDSTLVEVVTASTASELEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEIPGLFGVSGQPSGFPDTSGETSGVTELSGLSSGQPGISGEASGVLYGTSQPFGITDLSGETSGVPDLSGQPSGLPGFSGATSGVPDLVSGTTSGSGESSGITFVDTSLVEVAPTTFKEEEGLGSVELSGLPSGEADLSGKSGMVDVSGQFSGTVDSSGFTSQTPEFSGLPSGIAEVSGESSRAEIGSSLPSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELSGAHSGAPDMSGEHSGFLDLSGLQSGLIEPSGEPPGTPYFSGDFASTTNVSGESSVAMGTSGEASGLPEVTLITSEFVEGVTEPTISQELGQRPPVTHTPQLFESSGKVSTAGDISGATPVLPGSGVEVSSVPESSSETSAYPEAGFGASAAPEASREDSGSPDLSETTSAFHEANLERSSGLGVSGSTLTFQEGEASAAPEVSGESTTTSDVGTEAPGLPSATPTASGDRTEISGDLSGHTSQLGVVISTSIPESEWTQQTQRPAETHLEIESSSLLYSGEETHTVETATSPTDASIPASPEWKRESESTAAAPARSCAEEPCGAGTCKETEGHVICLCPPGYTGEHCNIDQEVCEEGWNKYQGHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQFENWRPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQKKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGHWEEPQITCTDPTTYKRRLQKRSSRHPRRSRPSTAH"},{"id":"SEQ_00046","a":"P17030","g":"ZNF25","d":"Zinc finger protein 25","L":456,"m":[{"c":"x[EDG]Kx[YFC]xCx[EKQ]Cx[KE]xFxx[KNL]xx[LF]xxH[QL][KRH]xH[TSA]","u":28,"sp":"tandem","x":"structured_like","cf":"high","why":"Twelve contiguous head-to-tail 28-residue structured-like repeats anchored by strictly invariant K3, C7, C10, F14, H23, and H27 positions along with strongly conserved hydrophobic ([YFC]5, [LF]20) and polar/charged linker residues.","i":[[114,141,"TEKACECKECGKFFCQKSALIVHQHTHS"],[142,169,"KGKSYDCDKCGKSFSKNEDLIRHQKIHT"],[170,197,"RDKTYECKECKKIFYHLSSLSRHLRTHA"],[198,225,"GEKPYECNQCEKSFYQKPHLTEHQKTHT"],[226,253,"GEKPFECTECGKFFYVKAYLMVHQKTHT"],[254,281,"GEKPYECKECGKAFSQKSHLTVHQRMHT"],[282,309,"GEKPYKCKECGKFFSRNSHLKTHQRSHT"],[310,337,"GEKPYECKECRKCFYQKSALTVHQRTHT"],[338,365,"GEKPFECNKCGKTFYYKSDLTKHQRKHT"],[366,393,"GEKPYECTECGKSFAVNSVLRLHQRTHT"],[394,421,"GEKPYACKECGKSFSQKSHFIIHQRKHT"],[422,449,"GEKPYECQECGETFIQKSQLTAHQKTHT"]]}],"s":"MNKFQGPVTLKDVIVEFTKEEWKLLTPAQRTLYKDVMLENYSHLVSVGYHVNKPNAVFKLKQGKEPWILEVEFPHRGFPEDLWSIHDLEARYQESQAGNSRNGELTKHQKTHTTEKACECKECGKFFCQKSALIVHQHTHSKGKSYDCDKCGKSFSKNEDLIRHQKIHTRDKTYECKECKKIFYHLSSLSRHLRTHAGEKPYECNQCEKSFYQKPHLTEHQKTHTGEKPFECTECGKFFYVKAYLMVHQKTHTGEKPYECKECGKAFSQKSHLTVHQRMHTGEKPYKCKECGKFFSRNSHLKTHQRSHTGEKPYECKECRKCFYQKSALTVHQRTHTGEKPFECNKCGKTFYYKSDLTKHQRKHTGEKPYECTECGKSFAVNSVLRLHQRTHTGEKPYACKECGKSFSQKSHFIIHQRKHTGEKPYECQECGETFIQKSQLTAHQKTHTKKRNAEK"},{"id":"SEQ_00056","a":"O76094","g":"SRP72","d":"Signal recognition particle subunit SRP72","L":671,"m":[{"c":"xxxxx[AVF]xxxxxxGxxxxAψxxφxxxxxxxxxxx(x){0,1}","u":"33-34","sp":"tandem","x":"structured_like","cf":"high","why":"Eleven 33-34 aa alpha-helical repeats arranged in tandem clusters with two internal linkers, anchored by strictly invariant A at position 18, conserved [AVF] at position 6, hydrophobic packing positions (ψ19, φ22), and frequent turn G13/P30-34 residues.","i":[[13,46,"ALWSEVNRYGQNGDFTRALKTVNKILQINKDDVT"],[47,79,"ALHCKVVCLIQNGSFKEALNVINTHTKVLANNS"],[80,112,"LSFEKAYCEYRLNRIENALKTIESANQQTDKLK"],[113,146,"ELYGQVLYRLERYDECLAVYRDLVRNSQDDYDEE"],[178,211,"LCYNTACALIGQGQLNQAMKILQKAEDLCRRSLS"],[228,261,"IHGQMAYILQLQGRTEEALQLYNQIIKLKPTDVG"],[303,336,"LQAIEFNKALLAMYTNQAEQCRKISASLQSQSPE"],[340,373,"PVLIQAAQLCREKQHTKAIELLQEFSDQHPENAA"],[375,407,"IKLTMAQLKISQGNISKACLILRSIEELKHKPG"],[408,441,"MVSALVTMYSHEEDIDSAIEVFTQAIQWYQNHQP"],[449,482,"LIREAANFKLKYGRKKEAISDLQQLWKQNPKDIH"]]}],"s":"MASGGSGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKELYGQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELCYNTACALIGQGQLNQAMKILQKAEDLCRRSLSEDTDGTEEDPQAELAIIHGQMAYILQLQGRTEEALQLYNQIIKLKPTDVGLLAVIANNIITINKDQNVFDSKKKVKLTNAEGVEFKLSKKQLQAIEFNKALLAMYTNQAEQCRKISASLQSQSPEHLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAAEIKLTMAQLKISQGNISKACLILRSIEELKHKPGMVSALVTMYSHEEDIDSAIEVFTQAIQWYQNHQPKSPAHLSLIREAANFKLKYGRKKEAISDLQQLWKQNPKDIHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVEALENSAGATYIRKKGGKVTGDSQPKEQGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGKGTQGATAGASSELDASKTVSSPPTSPRPGSAATVSASTSNIIPPRHQKPAGAPATKKKQQQKKKKGGKGGW"},{"id":"SEQ_00064","a":"P0C7N4","g":"TMEM191B","d":"Transmembrane protein 191B","L":346,"m":[{"c":"LPPIVxxx[AS]RRx","u":12,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Head-to-tail 12-aa tandem duplication in the N-terminal disordered tail sharing 7 exact column anchors (LPPIV and RR) plus a conserved PA/[AS] segment (9/12 aligned identities), making chance occurrence implausible; the central amphipathic heptad rod (residues 68-223) is flagged separately as coiled_coil_heptad.","i":[[10,21,"LPPIVIQPARRS"],[22,33,"LPPIVTPASRRL"]]}],"s":"MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYGGEPQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKVPPASPPPDLGRCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVLLTLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT"},{"id":"SEQ_00068","a":"Q8NEP3","g":"DNAAF1","d":"Dynein axonemal assembly factor 1","L":725,"m":[{"c":"PV[EK][AV]K[RG]EDG[DG]xEPEGTLPAE[TA][LP][LP][LP][SP][SP]","u":26,"sp":"tandem","x":"disordered_like","cf":"high","why":"Four contiguous head-to-tail 26-residue repeats in a proline/acidic-rich disordered region sharing an invariant PV..K.EDG..EPEGTLPAE core and alternating TLLLS[SP] / APPPPP C-terminal hexapeptides.","i":[[400,425,"PVEAKREDGGPEPEGTLPAETLLLSS"],[426,451,"PVEVKGEDGDGEPEGTLPAEAPPPPP"],[452,477,"PVEVKGEDGDQEPEGTLPAETLLLSP"],[478,503,"PVKVKGEDGDREPEGTLPAEAPPPPP"]]},{"c":"xLxψxx[NK]xφxxxE[NDI]ψ(x){5,8}L[RDN]","u":"22-25","sp":"tandem","x":"structured_like","cf":"high","why":"Six tandem 22-25 aa structured repeats (head-to-tail with one 2-aa linker before the sixth copy) anchored by spaced aliphatic/hydrophobic positions (xLxψxx[NK]xφ), a conserved E[NDI]ψ segment, and a C-terminal L[RDN] motif.","i":[[111,132,"TLYLHFKGFDRIENLEEYTGLR"],[133,154,"CLWLQSNGIQKIENLEAQTELR"],[155,176,"CLFLQMNLLRKIENLEPLQKLD"],[177,198,"ALNLSNNYIKTIENLSCLPVLN"],[199,221,"TLQMAHNHLETVEDIQHLQECLR"],[224,248,"VLDLSHNKLSDPEILSILESMPDLR"]]}],"s":"MHPEPSEPATGGAAELDCAQEPGVEESAGDHGSAGRGGCKEEINDPKEICVGSSDTSYHSQQKQSGDNGSGGHFAHPREDREDRGPRMTKSSLQKLCKQHKLYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPEILSILESMPDLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARGGYAAEKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQERGEMTSSDDGENVPASAEGKEEPPGDRETRQKMELFVKESFEAKDELCPEKPSGEEPPVEAKREDGGPEPEGTLPAETLLLSSPVEVKGEDGDGEPEGTLPAEAPPPPPPVEVKGEDGDQEPEGTLPAETLLLSPPVKVKGEDGDREPEGTLPAEAPPPPPLGAAREEPTPQAVATEGVFVTELDGTRTEDLETIRLETKETFCIDDLPDLEDDDETGKSLEDQNMCFPKIEVISSLSDDSDPELDYTSLPVLENLPTDTLSNIFAVSKDTSKAARVPFTDIFKKEAKRDLEIRKQDTKSPRPLIQELSDEDPSGQLLMPPTCQRDAAPLTSSGDRDSDFLAASSPVPTESAATPPETCVGVAQPSQALPTWDLTAFPAPKAS"},{"id":"SEQ_00071","a":"Q6ZMW2","g":"ZNF782","d":"Zinc finger protein 782","L":699,"m":[{"c":"TGE+P[YF]xCxxC[GD][KRE][AST]Fxx[KM]SxL[RI]xH[QHR]+[TIA]H","u":28,"sp":"tandem","x":"structured_like","cf":"high","why":"Eleven head-to-tail 28-aa tandem repeats anchored by invariant TGE+P[YF] linkers, CxxC and HxxxH coordination pairs, and fixed core F, S, and L positions (preceded N-terminally by several eroded, gapped pseudo-repeats lacking intact CxxC/HxxxH anchors).","i":[[389,416,"TGEKPYECPECGKAFSEKSRLRKHQRTH"],[417,444,"TGEKPYKCDGCDKAFSAKSGLRIHQRTH"],[445,472,"TGEKPFECHECGKSFNYKSILIVHQRTH"],[473,500,"TGEKPFECNECGKSFSHMSGLRNHRRTH"],[501,528,"TGERPYKCDECGKAFKLKSGLRKHHRTH"],[529,556,"TGEKPYKCNQCGKAFGQKSQLRGHHRIH"],[557,584,"TGEKPYKCNHCGEAFSQKSNLRVHHRTH"],[585,612,"TGEKPYQCEECGKTFRQKSNLRGHQRTH"],[613,640,"TGEKPYECNECGKAFSEKSVLRKHQRTH"],[641,668,"TGEKPYNCNQCGEAFSQKSNLRVHQRTH"],[669,696,"TGEKPYKCDKCGRTFSQKSSLREHQKAH"]]}],"s":"MNTFQASVSFQDVTVEFSQEEWQHMGPVERTLYRDVMLENYSHLVSVGYCFTKPELIFTLEQGEDPWLLEKEKGFLSRNSPEDSQPDEISEKSPENQGKHLLQVLFTNKLLTTEQEISGKPHNRDINIFRARMMPCKCDIAGSACQGLSLMAPHCQYSKEKAHERNVCDKWLISIKDGRTNTQEKSFAYSKIVKTLHHKEEVIQHQTIQTLGQDFEYNESRKAFLEKAALVTSNSTHPKGKSYNFNKFGENKYDKSTFIIPQNMNPEKSHYEFNDTGNCFCRITHKTLTGGKSFSQKSHIREHHRVHIGVKPFEYGKSFNRNSTLPVHQRTHATDKYSDYHPCTETFSYQSTFSVHQKVHIRAKPYEYNECGKSCSMNSHLIWPQKSHTGEKPYECPECGKAFSEKSRLRKHQRTHTGEKPYKCDGCDKAFSAKSGLRIHQRTHTGEKPFECHECGKSFNYKSILIVHQRTHTGEKPFECNECGKSFSHMSGLRNHRRTHTGERPYKCDECGKAFKLKSGLRKHHRTHTGEKPYKCNQCGKAFGQKSQLRGHHRIHTGEKPYKCNHCGEAFSQKSNLRVHHRTHTGEKPYQCEECGKTFRQKSNLRGHQRTHTGEKPYECNECGKAFSEKSVLRKHQRTHTGEKPYNCNQCGEAFSQKSNLRVHQRTHTGEKPYKCDKCGRTFSQKSSLREHQKAHPGD"},{"id":"SEQ_00087","a":"Q7L2J0","g":"MEPCE","d":"7SK snRNA methylphosphate capping enzyme","L":689,"m":[{"c":"φLψ[GP]x[ND]IxDPL[NS]LN[ST]xxDE","u":19,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Strongly conserved 19-aa internal duplication within the N-terminal disordered region sharing 9 identical anchor residues (L, I, DPL, LN, DE) and 6 physicochemically constrained positions separated by a 25-aa linker.","i":[[185,203,"FLLGGNIFDPLNLNSLLDE"],[229,247,"ILIPKDITDPLSLNTCTDE"]]}],"s":"MIEMAAEKEPFLVPAPPPPLKDESGGGGGPTVPPHQEAASGELRGGTERGPGRCAPSAGSPAAAVGRESPGAAATSSSGPQAQQHRGGGPQAQSHGEARLSDPPGRAAPPDVGEERRGGGGTELGPPAPPRPRNGYQPHRPPGGGGGKRRNSCNVGGGGGGFKHPAFKRRRRVNSDCDSVLPSNFLLGGNIFDPLNLNSLLDEEVSRTLNAETPKSSPLPAKGRDPVEILIPKDITDPLSLNTCTDEGHVVLASPLKTGRKRHRHRGQHHQQQQAAGGSESHPVPPTAPLTPLLHGEGASQQPRHRGQNRDAPQPYELNTAINCRDEVVSPLPSALQGPSGSLSAPPAASVISAPPSSSSRHRKRRRTSSKSEAGARGGGQGSKEKGRGSWGGRHHHHHPLPAAGFKKQQRKFQYGNYCKYYGYRNPSCEDGRLRVLKPEWFRGRDVLDLGCNVGHLTLSIACKWGPSRMVGLDIDSRLIHSARQNIRHYLSEELRLPPQTLEGDPGAEGEEGTTTVRKRSCFPASLTASRGPIAAPQVPLDGADTSVFPNNVVFVTGNYVLDRDDLVEAQTPEYDVVLCLSLTKWVHLNWGDEGLKRMFRRIYRHLRPGGILVLEPQPWSSYGKRKTLTETIYKNYYRIQLKPEQFSSYLTSPDVGFSSYELVATPHNTSKGFQRPVYLFHKARSPSH"},{"id":"SEQ_00101","a":"P60014","g":"KRTAP10-10","d":"Keratin-associated protein 10-10","L":251,"m":[{"c":"C[CY]QQSSCQP[DTA]CCT[SA]S[PC]C","u":17,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three highly conserved 17-residue Cys/Gln/Ser/Pro-rich cassettes with 13/17 invariant positions (C...QQSSCQPxCCTxSxC) separated by pentamer-repeat linkers.","i":[[74,90,"CYQQSSCQPDCCTSSPC"],[126,142,"CCQQSSCQPTCCTSSPC"],[168,184,"CCQQSSCQPACCTASCC"]]},{"c":"xxP[VTA]C","u":5,"sp":"dispersed","x":"mixed","cf":"high","why":"Ten non-overlapping copies of a 5-residue Cys/Pro repeat anchored by invariant P3 and C5, conserved aliphatic/Thr [VTA]4, and exclusively V or basic [KRH] at position 2, occurring in both tandem arrays and dispersed copies.","i":[[95,99,"CVPVC"],[100,104,"CVPVC"],[105,109,"CVPVC"],[110,114,"NKPVC"],[115,119,"FVPTC"],[147,151,"CVPVC"],[157,161,"YVPVC"],[194,198,"CHPVC"],[231,235,"CRPVC"],[236,240,"SRPAC"]]}],"s":"MAASTMSICSSACTDSWRVVDCPESCCEPCCCAPAPSLTLVCTPVSCVSSPCCQTACEPSACQSGYTSSCTTPCYQQSSCQPDCCTSSPCQQACCVPVCCVPVCCVPVCNKPVCFVPTCSESSPSCCQQSSCQPTCCTSSPCQQACCVPVCSKSVCYVPVCSGASTSCCQQSSCQPACCTASCCRPSSSVSLLCHPVCKSTCCVPVPSCGASASSCQPSCCRTASCVSLLCRPVCSRPACYSLCSGQKSSC"},{"id":"SEQ_00102","a":"Q86W92","g":"PPFIBP1","d":"Liprin-beta-1","L":1011,"m":[{"c":"K[WL][TD]xxxVxxWLx[EDS]x[GD]L[GPA]xYxx(x){29,34}Lx[RI]+[KRH][LA]xxx[LF]x[AIL]","u":"62-67","sp":"dispersed","x":"structured_like","cf":"high","why":"Three C-terminal ~62-67 aa structured domain repeats sharing an ungapped 21-residue N-terminal core (invariant K1, V7, W10, L11, L16, Y19) and a 12-residue basic-amphipathic C-terminal helix (invariant L, dibasic +[KRH] pair, and conserved hydrophobic register) separated by 10- and 24-aa linkers.","i":[[646,707,"KWTKEQVCNWLMEQGLGSYLNSGKHWIASGQTLLQASQQDLEKELGIKHSLHRKKLQLALQA"],[718,781,"KLDFNWVTRWLDDIGLPQYKTQFDEGRVDGRMLHYMTVDDLLSLKVVSVLHHLSIKRAIQVLRI"],[806,872,"KWTNHRVMEWLRSVDLAEYAPNLRGSGVHGGLMVLEPRFNVETMAQLLNIPPNKTLLRRHLATHFNL"]]}],"s":"MMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTAETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQKLDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKSLMAKLSSMKIKVGQMQYEKQRMEQKWESLKDELASLKEQLEEKESEVKRLQEKLVCKMKGEGVEIVDRDIEVQKMKKAVESLMAANEEKDRKIEDLRQCLNRYKKMQDTVVLAQGKDGEYEELLNSSSISSLLDAQGFSDLEKSPSPTPVMGSPSCDPFNTSVPEEFHTTILQVSIPSLLPATVSMETSEKSKLTPKPETSFEENDGNIILGATVDTQLCDKLLTSSLQKSSSLGNLKKETSDGEKETIQKTSEDRAPAESRPFGTLPPRPPGQDTSMDDNPFGTRKVRSSFGRGFFKIKSNKRTASAPNLAETEKETAEHLDLAGASSRPKDSQRNSPFQIPPPSPDSKKKSRGIMKLFGKLRRSQSTTFNPDDMSEPEFKRGGTRATAGPRLGWSRDLGQSNSDLDMPFAKWTKEQVCNWLMEQGLGSYLNSGKHWIASGQTLLQASQQDLEKELGIKHSLHRKKLQLALQALGSEEETNHGKLDFNWVTRWLDDIGLPQYKTQFDEGRVDGRMLHYMTVDDLLSLKVVSVLHHLSIKRAIQVLRINNFEPNCLRRRPSDENTIAPSEVQKWTNHRVMEWLRSVDLAEYAPNLRGSGVHGGLMVLEPRFNVETMAQLLNIPPNKTLLRRHLATHFNLLIGAEAQHQKRDAMELPDYVLLTATAKVKPKKLAFSNFGNLRKKKQEDGEEYVCPMELGQASGSASKKGFKPGLDMRLYEEDDLDRLEQMEDSEGTVRQIGAFSEGINNLTHMLKEDDMFKDFAARSPSASITDEDSNV"},{"id":"SEQ_00108","a":"E9PKD4","g":"NPIPA5","d":"Nuclear pore complex-interacting protein family member A5","L":350,"m":[{"c":"LKTP[SPA]E[RC]LL[YT]PLPPS(x){0,4}ADDN","u":"19-23","sp":"tandem","x":"disordered_like","cf":"high","why":"Three head-to-tail tandem copies in the proline-rich C-terminal disordered region sharing 15 invariant anchor positions (LKTP, E, LL, PLPPS, and ADDN) with a 4-residue internal insertion (ALPS/APPS) in copies 2 and 3, followed immediately by a partial 4th start (LKTPPECVC).","i":[[263,281,"LKTPSERLLYPLPPSADDN"],[282,304,"LKTPPECLLTPLPPSALPSADDN"],[305,327,"LKTPAECLLTPLPPSAPPSADDN"]]}],"s":"MFCCLGYEWLSGGCKTWHSAWVINTLADHRHRGTDFGGSPWLLIITVFLRSYKFAISLCTSYLCVSFLKTIFPSQNGHDGSTDVQQRARRSNCRRQEGIKIVLEDIFTLWRQVETKVRAKIRKMKVTTKVNRHDKINGKRKTAKEHLRKLSMKEREHGEKERQVSEAEENGKLDMKEIHTYMEMFQRAQALRRRAEDYYRCKITPSARKPLCNRVRMAAVEHRHSSGLPYWPYLTAETLKNRMGHQPPPPTQQHSIIDNSLSLKTPSERLLYPLPPSADDNLKTPPECLLTPLPPSALPSADDNLKTPAECLLTPLPPSAPPSADDNLKTPPECVCSLPFHPQRMIISRN"},{"id":"SEQ_00117","a":"Q96NG3","g":"ODAD4","d":"Outer dynein arm-docking complex subunit 4","L":672,"m":[{"c":"RxEPE[EK]ψxK","u":9,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 9-aa copies in the C-terminal disordered tail anchored by five invariant positions (R1, E3, P4, E5, K9) alongside conserved acidic/basic [EK]6 and large aliphatic ψ7 (V/L) positions.","i":[[529,537,"RDEPEKVVK"],[629,637,"RQEPEELKK"],[643,651,"RREPEELGK"]]},{"c":"[LRP]SGE[LTF][GES]","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Four non-overlapping 6-aa copies arranged as two closely spaced pairs separated by 17 residues in the C-terminal disordered region, anchored by an invariant SGE core and constrained flanking positions.","i":[[585,590,"LSGELG"],[592,597,"RSGETG"],[615,620,"PSGELE"],[623,628,"LSGEFS"]]}],"s":"MSDPEGETLRSTFPSYMAEGERLYLCGEFSKAAQSFSNALYLQDGDKNCLVARSKCFLKMGDLERSLKDAEASLQSDPAFCKGILQKAETLYTMGDFEFALVFYHRGYKLRPDREFRVGIQKAQEAINNSVGSPSSIKLENKGDLSFLSKQAENIKAQQKPQPMKHLLHPTKGEPKWKASLKSEKTVRQLLGELYVDKEYLEKLLLDEDLIKGTMKGGLTVEDLIMTGINYLDTHSNFWRQQKPIYARERDRKLMQEKWLRDHKRRPSQTAHYILKSLEDIDMLLTSGSAEGSLQKAEKVLKKVLEWNKEEVPNKDELVGNLYSCIGNAQIELGQMEAALQSHRKDLEIAKEYDLPDAKSRALDNIGRVFARVGKFQQAIDTWEEKIPLAKTTLEKTWLFHEIGRCYLELDQAWQAQNYGEKSQQCAEEEGDIEWQLNASVLVAQAQVKLRDFESAVNNFEKALERAKLVHNNEAQQAIISALDDANKGIIRELRKTNYVENLKEKSEGEASLYEDRIITREKDMRRVRDEPEKVVKQWDHSEDEKETDEDDEAFGEALQSPASGKQSVEAGKARSDLGAVAKGLSGELGTRSGETGRKLLEAGRRESREIYRRPSGELEQRLSGEFSRQEPEELKKLSEVGRREPEELGKTQFGEIGETKKTGNEMEKEYE"},{"id":"SEQ_00119","a":"Q6N022","g":"TENM4","d":"Teneurin-4","L":2769,"m":[{"c":"C(x){3,4}Cx[GNE][HNR]Gx[CYF](x){4,8}CxCxx[GS]ΩxGxxC","u":"27-31","sp":"periodic","x":"structured_like","cf":"high","why":"Eight cysteine-rich 27-31 aa repeats separated mostly by short 4-6 aa linkers (13 aa before the eighth copy), anchored by a conserved six-cysteine framework (with aromatic substitution at the third cysteine in two copies), an invariant G in the first inter-cysteine segment, and a C-terminal CxCxx[GS]ΩxGxxC signature.","i":[[566,592,"CPSNCYGNGDCISGTCHCFLGFLGPDC"],[597,623,"CPVLCSGNGQYMKGRCLCHSGWKGAEC"],[630,657,"CIDVACSNHGTCITGTCICNPGYKGESC"],[662,689,"CMDPTCSGRGVCVRGECHCSVGWGGTNC"],[696,724,"CLDQCSGHGTFLPDTGLCSCDPSWTGHDC"],[729,755,"CAADCGGHGVCVGGTCRCEDGWMGAAC"],[760,786,"CHPRCAEHGTCRDGKCECSPGWNGEHC"],[800,830,"CPGLCNGNGRCTLDLNGWHCVCQLGWRGAGC"]]},{"c":"xxφxY[DN]xx[GD]xxxxxxxxxxxx","u":21,"sp":"dispersed","x":"structured_like","cf":"high","why":"Ten 21-residue structured repeats sharing a conserved φxY[DN]xx[GD] turn/core motif (predominantly φxYDxxGR/Q/N), occurring as dispersed upstream copies (residues 1693-1923) followed by a tightly packed near-tandem C-terminal array (residues 2166-2355).","i":[[1693,1713,"TFYEYDSFGRLTNVTFPTGQV"],[1861,1881,"LRILYDQAGRPSLWSPSSRLN"],[1903,1923,"ERMEYDQAGRITSRIFADGKT"],[2166,2186,"MTVQYDNMGRVVKKELKVGPY"],[2192,2212,"YSYEYDADGQLQTVSINDKPL"],[2213,2233,"WRYSYDLNGNLHLLSPGNSAR"],[2235,2255,"TPLRYDIRDRITRLGDVQYKM"],[2267,2287,"DIFEYNSAGLLIKAYNRAGSW"],[2289,2309,"VRYRYDGLGRRVSSKSSHSHH"],[2335,2355,"TSLYYDLQGHLFAMELSSGDE"]]},{"c":"[LI]Y[VF]xDxxx[IV][RL]x[IR]","u":12,"sp":"dispersed","x":"structured_like","cf":"medium","why":"Four dispersed 12-residue hydrophobic-rich segments across residues 1247-1565 anchored by an invariant Y2 and D5 within a conserved [LI]Y[VF]xD core and C-terminal aliphatic/basic [IV][RL]x[IR] positions.","i":[[1243,1254,"LYVGDFNYIRRI"],[1361,1372,"IYFVDGTMIRRI"],[1421,1432,"LYVLDNNVVLQI"],[1550,1561,"LYVADLGNIRIR"]]}],"s":"MDVKERKPYRSLTRRRDAERRYTSSSADSEEGKAPQKSYSSSETLKAYDQDARLAYGSRVKDIVPQEAEEFCRTGANFTLRELGLEEVTPPHGTLYRTDIGLPHCGYSMGAGSDADMEADTVLSPEHPVRLWGRSTRSGRSSCLSSRANSNLTLTDTEHENTETDHPGGLQNHARLRTPPPPLSHAHTPNQHHAASINSLNRGNFTPRSNPSPAPTDHSLSGEPPAGGAQEPAHAQENWLLNSNIPLETRNLGKQPFLGTLQDNLIEMDILGASRHDGAYSDGHFLFKPGGTSPLFCTTSPGYPLTSSTVYSPPPRPLPRSTFARPAFNLKKPSKYCNWKCAALSAIVISATLVILLAYFVAMHLFGLNWHLQPMEGQMYEITEDTASSWPVPTDVSLYPSGGTGLETPDRKGKGTTEGKPSSFFPEDSFIDSGEIDVGRRASQKIPPGTFWRSQVFIDHPVHLKFNVSLGKAALVGIYGRKGLPPSHTQFDFVELLDGRRLLTQEARSLEGTPRQSRGTVPPSSHETGFIQYLDSGIWHLAFYNDGKESEVVSFLTTAIESVDNCPSNCYGNGDCISGTCHCFLGFLGPDCGRASCPVLCSGNGQYMKGRCLCHSGWKGAECDVPTNQCIDVACSNHGTCITGTCICNPGYKGESCEEVDCMDPTCSGRGVCVRGECHCSVGWGGTNCETPRATCLDQCSGHGTFLPDTGLCSCDPSWTGHDCSIEICAADCGGHGVCVGGTCRCEDGWMGAACDQRACHPRCAEHGTCRDGKCECSPGWNGEHCTIAHYLDRVVKEGCPGLCNGNGRCTLDLNGWHCVCQLGWRGAGCDTSMETACGDSKDNDGDGLVDCMDPDCCLQPLCHINPLCLGSPNPLDIIQETQVPVSQQNLHSFYDRIKFLVGRDSTHIIPGENPFDGGHACVIRGQVMTSDGTPLVGVNISFVNNPLFGYTISRQDGSFDLVTNGGISIILRFERAPFITQEHTLWLPWDRFFVMETIIMRHEENEIPSCDLSNFARPNPVVSPSPLTSFASSCAEKGPIVPEIQALQEEISISGCKMRLSYLSSRTPGYKSVLRISLTHPTIPFNLMKVHLMVAVEGRLFRKWFAAAPDLSYYFIWDKTDVYNQKVFGLSEAFVSVGYEYESCPDLILWEKRTTVLQGYEIDASKLGGWSLDKHHALNIQSGILHKGNGENQFVSQQPPVIGSIMGNGRRRSISCPSCNGLADGNKLLAPVALTCGSDGSLYVGDFNYIRRIFPSGNVTNILELRNKDFRHSHSPAHKYYLATDPMSGAVFLSDSNSRRVFKIKSTVVVKDLVKNSEVVAGTGDQCLPFDDTRCGDGGKATEATLTNPRGITVDKFGLIYFVDGTMIRRIDQNGIISTLLGSNDLTSARPLSCDSVMDISQVHLEWPTDLAINPMDNSLYVLDNNVVLQISENHQVRIVAGRPMHCQVPGIDHFLLSKVAIHATLESATALAVSHNGVLYIAETDEKKINRIRQVTTSGEISLVAGAPSGCDCKNDANCDCFSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFIRKNKPFLNTQNMYELSSPIDQELYLFDTTGKHLYTQSLPTGDYLYNFTYTGDGDITLITDNNGNMVNVRRDSTGMPLWLVVPDGQVYWVTMGTNSALKSVTTQGHELAMMTYHGNSGLLATKSNENGWTTFYEYDSFGRLTNVTFPTGQVSSFRSDTDSSVHVQVETSSKDDVTITTNLSASGAFYTLLQDQVRNSYYIGADGSLRLLLANGMEVALQTEPHLLAGTVNPTVGKRNVTLPIDNGLNLVEWRQRKEQARGQVTVFGRRLRVHNRNLLSLDFDRVTRTEKIYDDHRKFTLRILYDQAGRPSLWSPSSRLNGVNVTYSPGGYIAGIQRGIMSERMEYDQAGRITSRIFADGKTWSYTYLEKSMVLLLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSVGYYRNIYQPPEGNASVIQDFTEDGHLLHTFYLGTGRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGMLKTINLQNEGFTCTIRYRQIGPLIDRQIFRFTEEGMVNARFDYNYDNSFRVTSMQAVINETPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAYGRMKEVQYEIFRSLMYWMTVQYDNMGRVVKKELKVGPYANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNLHLLSPGNSARLTPLRYDIRDRITRLGDVQYKMDEDGFLRQRGGDIFEYNSAGLLIKAYNRAGSWSVRYRYDGLGRRVSSKSSHSHHLQFFYADLTNPTKVTHLYNHSSSEITSLYYDLQGHLFAMELSSGDEFYIACDNIGTPLAVFSGTGLMIKQILYTAYGEIYMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDHELWKHLSSSNVMPFNLYMFKNNNPISNSQDIKCFMTDVNSWLLTFGFQLHNVIPGYPKPDMDAMEPSYELIHTQMKTQEWDNSKSILGVQCEVQKQLKAFVTLERFDQLYGSTITSCQQAPKTKKFASSGSVFGKGVKFALKDGRVTTDIISVANEDGRRVAAILNHAHYLENLHFTIDGVDTHYFVKPGPSEGDLAILGLSGGRRTLENGVNVTVSQINTVLNGRTRRYTDIQLQYGALCLNTRYGTTLDEEKARVLELARQRAVRQAWAREQQRLREGEEGLRAWTEGEKQQVLSTGRVQGYDGFFVISVEQYPELSDSANNIHFMRQSEMGRR"},{"id":"SEQ_00122","a":"O43493","g":"TGOLN2","d":"Trans-Golgi network integral membrane protein 2","L":437,"m":[{"c":"+S[GHS][APS]-x[QK][TG]xx[DG]x[PST][NSG]","u":14,"sp":"tandem","x":"disordered_like","cf":"high","why":"14 contiguous head-to-tail 14-aa repeats in a polar/proline-rich disordered region anchored by invariant +S at positions 1-2 (mostly KSGAE), acidic position 5, [QK][TG] core, and [DG]x[PST][NSG] C-terminal tetrapeptide.","i":[[55,68,"KSHPEPQTPKDSPS"],[69,82,"KSSAEAQTPEDTPN"],[83,96,"KSGAEAKTQKDSSN"],[97,110,"KSGAEAKTQKGSTS"],[111,124,"KSGSEAQTTKDSTS"],[125,138,"KSHPELQTPKDSTG"],[139,152,"KSGAEAQTPEDSPN"],[153,166,"RSGAEAKTQKDSPS"],[167,180,"KSGSEAQTTKDVPN"],[181,194,"KSGADGQTPKDGSS"],[195,208,"KSGAEDQTPKDVPN"],[209,222,"KSGAEKQTPKDGSN"],[223,236,"KSGAEEQGPIDGPS"],[237,250,"KSGAEEQTSKDSPN"]]}],"s":"MRFVVALVLLNVAAAGAVPLLATESVKQEEAGVRPSAGNVSTHPSLSQRPGGSTKSHPEPQTPKDSPSKSSAEAQTPEDTPNKSGAEAKTQKDSSNKSGAEAKTQKGSTSKSGSEAQTTKDSTSKSHPELQTPKDSTGKSGAEAQTPEDSPNRSGAEAKTQKDSPSKSGSEAQTTKDVPNKSGADGQTPKDGSSKSGAEDQTPKDVPNKSGAEKQTPKDGSNKSGAEEQGPIDGPSKSGAEEQTSKDSPNKVVPEQPSRKDHSKPISNPSDNKELPKADTNQLADKGKLSPHAFKTESGEETDLISPPQEEVKSSEPTEDVEPKEAEDDDTGPEEGSPPKEEKEKMSGSASSENREGTLSDSTGSEKDDLYPNGSGNGSAESSHFFAYLVTAAILVAVLYIAHHNKRKIIAFVLEGKRSKVTRRPKASDYQRLDQKS"},{"id":"SEQ_00126","a":"P55197","g":"MLLT10","d":"Protein AF-10","L":1068,"m":[{"c":"CxψC(x){13,16}C[DN]xHGCxxAφHxxC(x){12,20}CxxC","u":"47-58","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of two N-terminal Cys/His-rich zinc-coordinating domains sharing eight conserved cysteines, two histidines, and an ungapped 14-aa central C[DN]xHGCxxAφHxxC motif flanked by CxψC and CxxC pairs.","i":[[25,71,"CCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKC"],[137,194,"CYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYC"]]},{"c":"[GN][GV][IT]ψGALx[GS]x[MQ][QL]","u":12,"sp":"dispersed","x":"mixed","cf":"medium","why":"Three closely spaced 12-aa hydrophobic-polar islands in the C-terminal region anchored by an invariant GAL tripeptide preceded by conserved small/aliphatic residues ([GN][GV][IT]ψ) and followed by x[GS]x[MQ][QL].","i":[[872,883,"GVTVGALASGMQ"],[896,907,"GGIIGALPGNQL"],[910,921,"NGIVGALNGVMQ"]]}],"s":"MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGSLKRLEDTTARFTNANFQEVSAHTSSGKDVSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRNDSYSHSQQSSATKDVHKGESGSQEGGVNSFSTLIGLPSTSAVTSQPKSFENSPGDLGNSSLPTAGYKRAQTSGIEEETVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLSVGSSPVGSEISMQYRHDGACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPSAVSSAAPAVATTQANTLSGSSLSQAPSHMYGNRSNSSMAALIAQSENNQTDQDLGDNSRNLVGRGSSPRGSLSPRSPVSSLQIRYDQPGNSSLENLPPVAASIEQLLERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSHQIHTFSAQTAPTTDSLNSSKSPHIGNSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMQPVTSTIPAVSAVGGIIGALPGNQLAINGIVGALNGVMQTPVTMSQNPTPLTHTTVPPNATHPMPATLTNSASGLGLLSDQQRQILIHQQQFQQLLNSQQLTPEQHQAFLYQLMQHHHQQHHQPELQQLQIPGPTQIPINNLLAGTQAPPLHTATTNPFLTIHGDNASQKVARLSDKTGPVAQEKS"},{"id":"SEQ_00132","a":"O43660","g":"PLRG1","d":"Pleiotropic regulator 1","L":514,"m":[{"c":"(x){8,9}φ[STH][GNA][HA](x){14,23}φφ[ST][GCA]xx[DN](x){0,1}oφ[KRH]xΩ[DKR]","u":"41-50","sp":"tandem","x":"structured_like","cf":"high","why":"Seven head-to-tail ~41-50 aa repeats across residues 192-490 anchored by a conserved [GN]H dipeptide (divergent in copy 7), an internal φφ[ST][GCA]xx[DN] beta-turn motif, and a C-terminal oφ[KRH]xΩ[DKR] (canonical WD) signature.","i":[[192,232,"PPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWD"],[233,274,"LASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWD"],[275,316,"LEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWD"],[317,358,"VRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWD"],[359,399,"LVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWK"],[400,440,"FPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWD"],[441,490,"WRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYR"]]}],"s":"MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKMAIKLRNEYGPVLHMPTSKENLKEKGPQNATDSYVHKQYPANQGQEVEYFVAGTHPYPPGPGVALTADTKIQRMPSESAAQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYREDDTATEETHPVSWKPEIIKRKRF"},{"id":"SEQ_00134","a":"Q96J84","g":"KIRREL1","d":"Kin of IRRE-like protein 1","L":757,"m":[{"c":"xP(x){12,20}φxC(x){8,10}φxW(x){27,44}φxC(x){10,14}φ(x){4,5}","u":"84-102","sp":"tandem","x":"structured_like","cf":"high","why":"Five contiguous 84-102 aa tandem repeats spanning residues 26-488, each defined by an N-terminal xP linker, an invariant pair of cysteines flanking a conserved tryptophan (φxC...φxW...φxC), and conserved flanking beta-strand hydrophobics.","i":[[26,118,"EPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLI"],[119,220,"PPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVH"],[221,306,"HPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHF"],[307,390,"APRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVN"],[391,488,"GPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLE"]]}],"s":"MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTHV"},{"id":"SEQ_00138","a":"Q86UU1","g":"PHLDB1","d":"Pleckstrin homology-like domain family B member 1","L":1377,"m":[{"c":"ESPR[LP]x[RG]","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Four dispersed copies in the central Pro/Ser-rich disordered region share an invariant ESPR tetrapeptide core followed by a conserved [LP] position (L in three copies, P in one) and a C-terminal [RG] residue.","i":[[309,315,"ESPRLSR"],[348,354,"ESPRLGG"],[442,448,"ESPRLGR"],[488,494,"ESPRPRR"]]}],"s":"MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN"},{"id":"SEQ_00145","a":"Q96I34","g":"PPP1R16A","d":"Protein phosphatase 1 regulatory subunit 16A","L":528,"m":[{"c":"x[AL]xxxxxxx[ALP]φ[HD]x[AC]xxxxxxxxφxx[LA]xxxxxx[ILT]","u":33,"sp":"dispersed","x":"structured_like","cf":"high","why":"Six 33-residue structured repeats arranged in two tandem triplets separated by a 29-residue divergent repeat linker, anchored by a conserved [ALP]φ[HD]x[AC] turn/helix motif and C-terminal φxx[LA] hydrophobic core.","i":[[98,130,"DLANEDGLTALHQCCIDDFREMVQQLLEAGANI"],[131,163,"NACDSECWTPLHAAATCGHLHLVELLIASGANL"],[164,196,"LAVNTDGNMPYDLCDDEQTLDCLETAMADRGIT"],[226,258,"HAPLDHGATLLHVAAANGFSEAAALLLEHRASL"],[259,291,"SAKDQDGWEPLHAAAYWGQVPLVELLVAHGADL"],[292,324,"NAKSLMDETPLDVCGDEEVRAKLLELKHKHDAL"]]},{"c":"[QL][QR]PPPxx[PE]-xPE","u":12,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed copies in the C-terminal disordered tail featuring a PPP tract flanked by conserved N-terminal [QL][QR], internal [PE]- acidic dyad, and invariant C-terminal PE anchor.","i":[[373,384,"QQPPPTSPEPPE"],[395,406,"LRPPPPEEDNPE"],[469,480,"QRPPPEGPESPE"]]}],"s":"MAEHLELLAEMPMVGRMSTQERLKHAQKRRAQQVKMWAQAEKEAQGKKGPGERPRKEAASQGLLKQVLFPPSVVLLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLELKHKHDALLRAQSRQRSLLRRRTSSAGSRGKVVRRVSLTQRTDLYRKQHAQEAIVWQQPPPTSPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRVGGSPVRHLYSKRLDRSVSYQLSPLDSTTPHTLVHDKAHHTLADLKRQRAAAKLQRPPPEGPESPETAEPGLPGDTVTPQPDCGFRAGGDPPLLKLTAPAVEAPVERRPCCLLM"},{"id":"SEQ_00168","a":"Q9UN74","g":"PCDHA4","d":"Protocadherin alpha-4","L":947,"m":[{"c":"(x){6,13}xxψxxx(x){12,13}D[ALK][DG](x){34,39}ψDx[ET](x){25,27}ψxψx-(x){3,4}[APV]Pxφ","u":"105-113","sp":"tandem","x":"structured_like","cf":"high","why":"Six head-to-tail structured repeats of 105-113 aa sharing conserved aliphatic positions, internal D[ALK][DG] and ψDx[ET] motifs, and a C-terminal ψxψx-(x){3,4}[APV]Pxφ boundary motif (DxNDNxPx[FL] in the first five copies).","i":[[27,133,"GNGQLHYSVSEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKGRGGLLEVNLQNGILFVNSRIDREELCRRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPVF"],[134,242,"PATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFSLEKPPDDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAPAF"],[243,350,"DRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDL"],[351,455,"EFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAF"],[456,565,"AQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAPAL"],[566,678,"LAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKA"]]}],"s":"MEFSWGSGQESRRLLLLLLLLAAWEAGNGQLHYSVSEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKGRGGLLEVNLQNGILFVNSRIDREELCRRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFSLEKPPDDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRALVGAVGPDAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSALPTEGACAPGKPTLVCSSAVGSWSYSQQRRPRVCSGEGPPKTDLMAFSPSLPDSRDREDQLQTTEESFAKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ"},{"id":"SEQ_00172","a":"Q9UBT3","g":"DKK4","d":"Dickkopf-related protein 4","L":224,"m":[{"c":"C(x){0,4}D(x){0,32}C[CG]PG[LT][CL]C(x){3,17}VC","u":"25-50","sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed cysteine-rich repeats anchored by an N-terminal C(x){0,4}D segment, a highly conserved C[CG]PG[LT][CL]C core motif, and an invariant C-terminal VC dipeptide.","i":[[41,90,"CLSDTDCNTRKFCLQPRDEKPFCATCRGLRRRCQRDAMCCPGTLCVNDVC"],[145,176,"CLRTFDCGPGLCCARHFWTKICKPVLLEGQVC"],[194,218,"CDCGPGLLCRSQLTSNRQHARLRVC"]]}],"s":"MVAAVLLGLSWLCSPLGALVLDFNNIRSSADLHGARKGSQCLSDTDCNTRKFCLQPRDEKPFCATCRGLRRRCQRDAMCCPGTLCVNDVCTTMEDATPILERQLDEQDGTHAEGTTGHPVQENQPKRKPSIKKSQGRKGQEGESCLRTFDCGPGLCCARHFWTKICKPVLLEGQVCSRRGHKDTAQAPEIFQRCDCGPGLLCRSQLTSNRQHARLRVCQKIEKL"},{"id":"SEQ_00182","a":"A6NCL7","g":"ANKRD33B","d":"Ankyrin repeat domain-containing protein 33B","L":494,"m":[{"c":"GxT[AG]LψxA[AC]xxGxx[DI]xxx[AY]L[ALM](x){3,5}φD[VL]","u":"27-29","sp":"periodic","x":"structured_like","cf":"high","why":"Three conserved 27-29 aa structured repeats (preceded by a divergent N-terminal cap) share invariant G, T, L, A, G, L, and D anchors with conserved hydrophobic core positions and regular 6-residue linkers.","i":[[121,148,"GRTGLIVACYHGFVDTVVALAECPHVDV"],[155,183,"GNTALITAAQAGHAIITNYLLNYFPGLDL"],[190,216,"GFTALMKAAMQGRTDCIRALMLAGADV"]]},{"c":"E[SG]VP","u":4,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Three contiguous head-to-tail tetrapeptide repeats in the acidic N-terminal disordered tail share invariant E, V, and P anchors flanking a constrained [SG] position.","i":[[73,76,"ESVP"],[77,80,"EGVP"],[81,84,"ESVP"]]}],"s":"MVLLAGTGPEGGGARCMTPPPPSPPRGAQVEEDPADYEEFEDFSSLPDTRSIASDDSFYPFEDEEEHGVESAESVPEGVPESVPETATLLRAACANNVGLLRTLVRRGVSVEEAQETDRNGRTGLIVACYHGFVDTVVALAECPHVDVNWQDSEGNTALITAAQAGHAIITNYLLNYFPGLDLERRNAFGFTALMKAAMQGRTDCIRALMLAGADVHARDPRRGMSPQEWATYTGRVDAVRLMQRLLERPCPEQFWEKYRPELPPPPEAARKPAGSKNCLQRLTDCVLSVLTPRSVRGPEDGGVLDHMVRMTTSLYSPAVAIVCQTVCPESPPSVGKRRLAVQEILAARAARGPQAQEEDEVGGAGQRGRTGQEDADSREGSPRAGLPPALGSRGPAAPAPRKASLLPLQRLRRRSVRPGVVVPRVRVSKAPAPTFQPERPARKGSTKDSGHLQIPKWRYKEAKEEKRKAEEAEKKRQAEAQKERRTAPWKKRT"},{"id":"SEQ_00189","a":"O14641","g":"DVL2","d":"Segment polarity protein dishevelled homolog DVL-2","L":736,"m":[{"c":"Px[PL][HP]PY","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 6-aa motifs in the C-terminal Pro/Ser/Gly-rich disordered region share fixed N-terminal P and C-terminal PY anchors flanking constrained [PL][HP] internal positions.","i":[[556,561,"PAPHPY"],[563,568,"PQPPPY"],[662,667,"PGLHPY"]]}],"s":"MAGSSTGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSDNPQPEMAPPVHEPRAELAPPAPPLPPLPPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLRRERPRRRDSSEHGAGGHRTGGPSRLERHLAGYESSSTLMTSELESTSLGDSDEEDTMSRFSSSTEQSSASRLLKRHRRRRKQRPPRLERTSSFSSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTGTFPAYPGSSSMSTITSGSSLPDGCEGRGLSVHTDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGDLSGGCESYLVNLSLNDNDGSSGASDQDTLAPLPGATPWPLLPTFSYQYPAPHPYSPQPPPYHELSSYTYGGGSASSQHSEGSRSSGSTRSDGGAGRTGRPEERAPESKSGSGSESEPSSRGGSLRRGGEASGTSDGGPPPSRGSTGGAPNLRAHPGLHPYGPPPGMALPYNPMMVVMMPPPPPPVPPAVQPPGAPPVRDLGSVPPELTASRQSFHMAMGNPSEFFVDVM"},{"id":"SEQ_00204","a":"Q5BKZ1","g":"ZNF326","d":"DBIRD complex subunit ZNF326","L":582,"m":[{"c":"MDRDYG[PH]GSYGG","u":12,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Head-to-tail tandem 12-aa duplication in the N-terminal G/S/Y-rich disordered region with 11 of 12 positions strictly identical (fixed M, D, R, Y, S, G anchors) and a single P/H substitution.","i":[[22,33,"MDRDYGPGSYGG"],[34,45,"MDRDYGHGSYGG"]]}],"s":"MDFEDDYTHSACRNTYQGFNGMDRDYGPGSYGGMDRDYGHGSYGGQRSMDSYLNQSYGMDNHSGGGGGSRFGPYESYDSRSSLGGRDLYRSGYGFNEPEQSRFGGSYGGRFESSYRNSLDSFGGRNQGGSSWEAPYSRSKLRPGFMEDRGRENYSSYSSFSSPHMKPAPVGSRGRGTPAYPESTFGSRNYDAFGGPSTGRGRGRGHMGDFGSIHRPGIVVDYQNKSTNVTVAAARGIKRKMMQPFNKPSGTFIKKPKLAKPMEKISLSKSPTKTDPKNEEEEKRRIEARREKQRRRREKNSEKYGDGYRMAFTCSFCKFRTFEEKDIELHLESSSHQETLDHIQKQTKFDKVVMEFLHECMVNKFKKTSIRKQQTNNQTEVVKIIEKDVMEGVTVDDHMMKVETVHCSACSVYIPALHSSVQQHLKSPDHIKGKQAYKEQIKRESVLTATSILNNPIVKARYERFVKGENPFEIQDHSQDQQIEGDEEDEEKIDEPIEEEEDEDEEEEAEEVGEVEEVEEVEEVREGGIEGEGNIQGVGEGGEVGVVGEVEGVGEVEEVEELEEETAKEEPADFPVEQPEEN"},{"id":"SEQ_00251","a":"P19835","g":"CEL","d":"Bile salt-activated lipase","L":753,"m":[{"c":"[GE][ATP][PTA]PV[PT]PT[GD]D[SA]","u":11,"sp":"tandem","x":"disordered_like","cf":"high","why":"Seventeen head-to-tail 11-residue repeats in the C-terminal proline/polar-rich tail anchored by an invariant PVxPTxD core (predominantly GAPPVPPTGDS and E[AT][TP]PVPPTGDS).","i":[[556,566,"EATPVPPTGDS"],[567,577,"EATPVPPTGDS"],[578,588,"ETAPVPPTGDS"],[589,599,"GAPPVPPTGDS"],[600,610,"GAPPVPPTGDS"],[611,621,"GAPPVPPTGDS"],[622,632,"GAPPVPPTGDS"],[633,643,"GAPPVPPTGDS"],[644,654,"GAPPVPPTGDS"],[655,665,"GAPPVPPTGDS"],[666,676,"GAPPVPPTGDA"],[677,687,"GPPPVPPTGDS"],[688,698,"GAPPVPPTGDS"],[699,709,"GAPPVTPTGDS"],[710,720,"ETAPVPPTGDS"],[721,731,"GAPPVPPTGDS"],[732,742,"EAAPVPPTDDS"]]}],"s":"MGRLQLVVLGLTCCWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKALENPQPHPGWQGTLKAKNFKKRCLQATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPLAGLEYPMLHYVGFVPVIDGDFIPADPINLYANAADIDYIAGTNNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSEFTITKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIALAQHRANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLRYWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAVIRF"},{"id":"SEQ_00253","a":"P57796","g":"CABP4","d":"Calcium-binding protein 4","L":275,"m":[{"c":"ELxxφxx[EH]φ[DK]x[DNR]x[DG]Gx[IV][STD]xxE[LF]x[EDM]xψ","u":26,"sp":"dispersed","x":"structured_like","cf":"high","why":"Four 26-residue repeats separated by 10-15 aa linkers in the C-terminal structured region, anchored by invariant EL, central Gx[IV], and E[LF] positions flanked by conserved hydrophobic and acidic residues.","i":[[133,158,"ELQAAFEEFDTDRDGYISHRELGDCM"],[169,194,"ELLEVSQHIKMRMGGRVDFEEFVELI"],[210,235,"ELRIAFREFDRDRDGRITVAELREAV"],[247,272,"ELDEMLREVDLNGDGTVDFDEFVMML"]]}],"s":"MTTEQARGQQGPNLAIGRQKPPAGVVTPKSDAEEPPLTRKRSKKERGLRGSRKRTGSSGEQTGPEAPGSSNNPPSTGEGPAGAPPASPGPASSRQSHRHRPDSLHDAAQRTYGPLLNRVFGKDRELGPEELDELQAAFEEFDTDRDGYISHRELGDCMRTLGYMPTEMELLEVSQHIKMRMGGRVDFEEFVELIGPKLREETAHMLGVRELRIAFREFDRDRDGRITVAELREAVPALLGEPLAGPELDEMLREVDLNGDGTVDFDEFVMMLSRH"},{"id":"SEQ_00267","a":"Q3SY00","g":"TSGA10IP","d":"Testis-specific protein 10-interacting protein","L":556,"m":[{"c":"φQ[AH]xx[RQ]xxxxx[ARF]","u":12,"sp":"dispersed","x":"structured_like","cf":"medium","why":"Four 12-residue amphipathic helical repeats in the C-terminal half anchored by a conserved N-terminal hydrophobic-glutamine (φQ) dipeptide, a predominantly alanine third position, a basic/polar anchor at position 6, and basic/hydrophobic C-terminal residues.","i":[[348,359,"FQASKRNGKAYA"],[387,398,"LQAWERQRQEER"],[458,469,"IQHRVQARPFLF"],[473,484,"MQANARLTVTRR"]]}],"s":"MGQDTDMLNTYQQLVRTPSVRPGQDVRLQAPGTRTGLLKLLSTVSQDKQGCLGSGDGVPNQDLQQRSQSSRQTAKKDRKPRGQSKKGQGSEESEDHFPLLPRKPSFPFQWAWESIATDVRAVLQPSSPTPGHQALPMPSSFSQRQSRRKSTANLPEAHGCCWKTEAQNLKARQQLGAWGGVSIPTGKGELGSEPPSGLQLPGRRPGSGSASDKQVQLQSLGAEEAERGLSSGVLPQRPRRGSISEEEQFSEATEEAEEGEHRTPCRRRAGCQRKGQISGEEASDEGEVQGQSQGSSPSFNNLRRRQWRKTRAKELQGPWDLEKLHRQLQRDLDCGPQKLPWKTLRAAFQASKRNGKAYASGYDETFVSANLPNRTFHKRQEATRSLLQAWERQRQEERQQAELRRARTQHVQRQVAHCLAAYAPRGSRGPGAAQRKLEELRRQERQRFAEYQAELQGIQHRVQARPFLFQQAMQANARLTVTRRFSQVLSALGLDEEQLLSEAGKVDREGTPRKPRSHRSMGVRMEHSPQRPPRTEPTGSQPDRHYNPSLDPECSP"},{"id":"SEQ_00269","a":"Q96BR9","g":"ZBTB8A","d":"Zinc finger and BTB domain-containing protein 8A","L":441,"m":[{"c":"Ω(x){1,2}CxxCxxxφxxxxx[LP]xx[HL](x){3,4}H","u":"23-25","sp":"dispersed","x":"structured_like","cf":"high","why":"Three 23-25 aa repeats anchored by an N-terminal aromatic residue (F/Y), an invariant CxxC pair, a conserved hydrophobic core residue four positions after the second cysteine, a central L/P position, and a conserved C-terminal histidine.","i":[[282,304,"FKCPYCTHVVKRKADLKRHLRCH"],[310,333,"YPCQACGKRFSRLDHLSSHFRTIH"],[362,386,"YRLCNECLAEFGIDSLPIDLEAEQH"]]}],"s":"MEISSHQSHLLQQLNEQRRQDVFCDCSILVEGKVFKAHRNVLFASSGYFKMLLSQNSKETSQPTTATFQAFSPDTFTVILDFVYSGKLSLTGQNVIEVMSAASFLQMTDVISVCKTFIKSSLDISEKEKDRYFSLSDKDANSNGVERSSFYSGGWQEGSSSPRSHLSPEQGTGIISGKSWNKYNYHPASQKNTQQPLAKHEPRKESIKKTKHLRLSQPSEVTHYKSSKREVRTSDSSSHVSQSEEQAQIDAEMDSTPVGYQYGQGSDVTSKSFPDDLPRMRFKCPYCTHVVKRKADLKRHLRCHTGERPYPCQACGKRFSRLDHLSSHFRTIHQACKLICRKCKRHVTDLTGQVVQEGTRRYRLCNECLAEFGIDSLPIDLEAEQHLMSPSDGDKDSRWHLSEDENRSYVEIVEDGSADLVIQQVDDSEEEEEKEIKPNIR"},{"id":"SEQ_00277","a":"Q9NW82","g":"WDR70","d":"WD repeat-containing protein 70","L":654,"m":[{"c":"xxxxxφ[SHD](x){4,6}φψ(x){10,17}φ-","u":"26-32","sp":"periodic","x":"structured_like","cf":"high","why":"Seven periodically spaced 26-32 aa structural repeats spanning residues 185-501, each conserving an aromatic/hydrophobic residue followed by S/H/D, a 4-6 aa turn into a hydrophobic φψ doublet, and a C-terminal hydrophobic-acidic (WD/WE/ID/FE/YD) dipeptide.","i":[[185,210,"VSALGLDPSGARLVTGGYDYDVKFWD"],[232,257,"IKSLQYSNTGDMILVVSGSSQAKVID"],[286,312,"LHTGSWHPKIKGEFMTCSNDATVRTWE"],[335,360,"PTTCTYSRDGNLIAAACQNGSIQIWD"],[381,406,"TSCVTFSYDGNVLASRGGDDSLKLWD"],[426,457,"MTDCCFSPDDKLIVTGTSIQRGCGSGKLVFFE"],[474,500,"VVRCLWHPKLNQIMVGTGNGLAKVYYD"]]}],"s":"MERSGPSEVTGSDASGPDPQLAVTMGFTGFGKKARTFDLEAMFEQTRRTAVERSRKTLEAREKEEEMNREKELRRQNEDIEPTSSRSNVVRDCSKSSSRDTSSSESEQSSDSSDDELIGPPLPPKMVGKPVNFMEEDILGPLPPPLNEEEEEAEEEEEEEEEEENPVHKIPDSHEITLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKPRTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQIWDRNLTVHPKFHYKQAHDSGTDTSCVTFSYDGNVLASRGGDDSLKLWDIRQFNKPLFSASGLPTMFPMTDCCFSPDDKLIVTGTSIQRGCGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNKSQRGAKLCVVKTQRKAKQAETLTQDYIITPHALPMFREPRQRSTRKQLEKDRLDPLKSHKPEPPVAGPGRGGRVGTHGGTLSSYIVKNIALDKTDDSNPREAILRHAKAAEDSPYWVSPAYSKTQPKTMFAQVESDDEEAKNEPEWKKRKI"},{"id":"SEQ_00281","a":"P33241","g":"LSP1","d":"Lymphocyte-specific protein 1","L":339,"m":[{"c":"S[KT][KI][SD]xW[LE](x){10,12}[RKS]TP[SK](x){1,2}+","u":"23-25","sp":"dispersed","x":"disordered_like","cf":"high","why":"Three bipartite 23-25 aa repeats in the C-terminal disordered region pairing an N-terminal S[KT][KI][SD]xW[LE] tryptophan-anchored motif with a C-terminal [RKS]TP[SK](x){1,2}+ proline-directed basic motif across a 10-12 aa linker.","i":[[225,249,"SKIDQWLEQYTQAIETAGRTPKLAR"],[262,284,"STKSRWETGEVQAQSAAKTPSCK"],[292,316,"SKKSLWEQKGGSKTSSTIKSTPSGK"]]}],"s":"MAEASSDPGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPKQEMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRPGLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLVLEGTIEQSSPPLSPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIETAGRTPKLARQASIELPSMAVASTKSRWETGEVQAQSAAKTPSCKDIVAGDMSKKSLWEQKGGSKTSSTIKSTPSGKRYKFVATGHGKYEKVLVEGGPAP"},{"id":"SEQ_00286","a":"Q9UQ26","g":"RIMS2","d":"Regulating synaptic membrane exocytosis protein 2","L":1411,"m":[{"c":"QLxVxIψxA+xL(x){10,11}PYVKψYφLxxxxxxxK++TKxφ+KTLEPxΩoQxφxΩx(x){7,11}LxIxψW(x){10,11}FψG(x){16,17}WΩKL","u":"107-110","sp":"dispersed","x":"structured_like","cf":"high","why":"Two ~107-110 aa globular domain copies separated by a 340 aa disordered linker share strong multi-segment sequence architecture, anchored by N-terminal QLxVxIψxA+xL, central PYVKψYφL and K++TKxφ+KTLEPxΩoQxφxΩx motifs, internal LxIxψW and FψG elements, and a C-terminal WΩKL motif.","i":[[821,930,"QLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPHWYKL"],[1271,1377,"QLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKL"]]}],"s":"MSAPVGPRGRLAPIPAASQPPLQPEMPDLSHLTEEERKIILAVMDRQKKKVKEEHKPQLTQWFPFSGITELVNNVLQPQQKQQNEKEPQTKLHQQFEMYKEQVKKMGEESQQQQEQKGDAPTCGICHKTKFADGCGHNCSYCQTKFCARCGGRVSLRSNKVMWVCNLCRKQQEILTKSGAWFYNSGSNTPQQPDQKVLRGLRNEEAPQEKKPKLHEQTQFQGPSGDLSVPAVEKSRSHGLTRQHSIKNGSGVKHHIASDIASDRKRSPSVSRDQNRRYDQREEREEYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLSYRDSNRRSHRHSKEYIVDDEDVESRDEYERQRREEEYQSRYRSDPNLARYPVKPQPYEEQMRIHAEVSRARHERRHSDVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSMERTREAQGPSSYAQRTTNHSPPTPRRSPLPIDRPDLRRTDSLRKQHHLDPSSAVRKTKREKMETMLRNDSLSSDQSESVRPPPPKPHKSKKGGKMRQISLSSSEEELASTPEYTSCDDVEIESESVSEKGDSQKGKRKTSEQAVLSDSNTRSERQKEMMYFGGHSLEEDLEWSEPQIKDSGVDTCSSTTLNEEHSHSDKHPVTWQPSKDGDRLIGRILLNKRLKDGSVPRDSGAMLGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGATFEEVYNIILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFLSGQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPHWYKLQTHDVSSLPLPHPSPYMPRRQLHGESPTRRLQRSKRISDSEVSDYDCDDGIGVVSDYRHDGRDLQSSTLSVPEQVMSSNHCSPSGSPHRVDVIGRTRSWSPSVPPPQSRNVEQGLRGTRTMTGHYNTISRMDRHRVMDDHYSPDRDRDCEAADRQPYHRSRSTEQRPLLERTTTRSRSTERPDTNLMRSMPSLMTGRSAPPSPALSRSHPRTGSVQTSPSSTPVAGRRGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEGNLIFPGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQSSLESSTGPSYSRS"},{"id":"SEQ_00295","a":"Q8IWC1","g":"MAP7D3","d":"MAP7 domain-containing protein 3","L":876,"m":[{"c":"xSφ-AxP[EK]","u":8,"sp":"tandem","x":"disordered_like","cf":"high","why":"15-copy 8-aa repeat in the central proline/serine-rich disordered region (including a 12-copy head-to-tail tandem array at residues 356-451 plus 3 flanking units), anchored by invariant P at position 7, [EK] at position 8, hydrophobic φ at position 3, and strongly conserved S2, acidic [ED]4, and A5.","i":[[293,300,"EKVETPPK"],[317,324,"TSMEASPK"],[356,363,"MSMDASPE"],[364,371,"LSIEALPK"],[372,379,"VDLETVPK"],[380,387,"VSIVASPE"],[388,395,"ASLEAPPE"],[396,403,"VSLEALPE"],[404,411,"VSVEAAPE"],[412,419,"GSLEAPPK"],[420,427,"GSAEVAPK"],[428,435,"ESVKGSPK"],[436,443,"ESMEASPE"],[444,451,"AMVKASPK"],[456,463,"ASMEASPK"]]}],"s":"MMADGAAAGAGGSPSLRELRARMVAAANEIAKERRKQDVVNRVATHSSNIRSTFKPVIDGSMLKNDIKQRLARERREEKRRQQDANKETQLLEKERKTKLQYEKQMEERQRKLKERKEKEEQRRIAAEEKRHQKDEAQKEKFTAILYRTLERRRLADDYQQKRWSWGGSAMANSESKTANKRSASTEKLEQGTSALIRQMPLSSAGLQNSVAKRKTDKERSSSLNRRDSNLHSSTDKEQAERKPRVTGVTNYVMQYVTVPLRKCTSDELRAVMFPMSTMKIPPQTKVEESPLEKVETPPKASVDAPPQVNVEVFCNTSMEASPKAGVGMAPEVSTDSFPVVSVDVSPVVSTYDSEMSMDASPELSIEALPKVDLETVPKVSIVASPEASLEAPPEVSLEALPEVSVEAAPEGSLEAPPKGSAEVAPKESVKGSPKESMEASPEAMVKASPKTSLEASMEASPKAKARDAPKKSEMDKQALIPIAKKRLSSYTECYKWSSSPENACGLPSPISTNRQIQKNCPPSPLPLISKQSPQTSFPYKIMPIQHTLSVQSASSTVKKKKETVSKTTNRCEALSQRHMIYEESGNKSTAGIMNAEAATKILTELRRLAREQREKEEEERQREEMQQRVIKKSKDMAKEAVGGQAEDHLKLKDGQQQNETKKKKGWLDQEDQEAPLQKGDAKIKAQEEADKRKKEHERIMLQNLQERLERKKRIEEIMKRTRKTDVNASKVTETSSHDIYEEAEADNEESDKDSLNEMFPSAILNGTGSPTKFKMPFNNAKKMTHKLVFLEDGTSQVRKEPKTYFNGDLKNFRQKSMKDTSIQEVVSRPSSKRMTSHTTKTRKADETNTTSRSSAQTKSEGFHDILPKSSDTFRQ"},{"id":"SEQ_00310","a":"Q96SZ4","g":"ZSCAN10","d":"Zinc finger and SCAN domain-containing protein 10","L":780,"m":[{"c":"[FYH]xCxxCG[KRH][SRG]Fx[RQ]xxxLx+H(x){3,4}H[TAS]G-+P","u":"28-29","sp":"tandem","x":"structured_like","cf":"high","why":"14 copies of a 28-29 aa Cys2-His2 repeat across the C-terminal half with invariant CxxCG, F, L, and H(x){3,4}H anchors (4-residue H-H spacing in copy 1, 3-residue in copies 2-14) and a conserved TGE[KR]P-like inter-unit linker; arranged primarily in head-to-tail tandem arrays interrupted by three short linkers (16, 18, and 6 aa).","i":[[347,375,"FICADCGVSFPQLSRLKAHQLRSHPAGRS"],[376,403,"FLCLCCGKSFGRSSILKLHMRTHTDERP"],[404,431,"HACHLCGHRFRQSSHLSKHLLTHSSEPA"],[432,459,"FLCAECGRGFQRRASLVQHLLAHAQDQK"],[476,503,"VLCSHCGQSFQRRSSLKRHLRIHARDKD"],[522,549,"FVCSDCGKAFRRSEHLVAHRRVHTGERP"],[550,577,"FSCQACGRSFTQSSQLVSHQRVHTGEKP"],[578,605,"YACPQCGKRFVRRASLARHLLTHGGPRP"],[606,633,"HHCTQCGKSFGQTQDLARHQRSHTGEKP"],[634,661,"CRCSECGEGFSQSAHLARHQRIHTGEKP"],[662,689,"HACDTCGHRFRNSSNLARHRRSHTGERP"],[690,717,"YSCQTCGRSFRRNAHLRRHLATHAEPGQ"],[724,751,"QECVECGKSFSRSCNLLRHLLVHTGARP"],[752,779,"YSCTQCGRSFSRNSHLLRHLRTHARETL"]]}],"s":"MLGESVPAAVEQEQLGEVKLEEEEAVSPEDPRRPESRLRPEVAHQLFRCFQYQEDMGPRASLSRLRELCGHWLRPALHTKKQILELLVLEQFLSVLPPHLLGRLQGQPLRDGEEVVLLLEGIHREPSHAGPLDFSCNAGKSCPRADVTLEEKGCASQVPSHSPKKELPAEEPSVLGPSDEPPRPQPRAAQPAEPGQWRLPPSSKQPLSPGPQKTFQALQESSPQGPSPWPEESSRDQELAAVLECLTFEDVPENKAWPAHPLGFGSRTPDKEEFKQEEPKGAAWPTPILAESQADSPGVPGEPCAQSLGRGAAASGPGEDGSLLGSSEILEVKVAEGVPEPNPELQFICADCGVSFPQLSRLKAHQLRSHPAGRSFLCLCCGKSFGRSSILKLHMRTHTDERPHACHLCGHRFRQSSHLSKHLLTHSSEPAFLCAECGRGFQRRASLVQHLLAHAQDQKPPCAPESKAEAPPLTDVLCSHCGQSFQRRSSLKRHLRIHARDKDRRSSEGSGSRRRDSDRRPFVCSDCGKAFRRSEHLVAHRRVHTGERPFSCQACGRSFTQSSQLVSHQRVHTGEKPYACPQCGKRFVRRASLARHLLTHGGPRPHHCTQCGKSFGQTQDLARHQRSHTGEKPCRCSECGEGFSQSAHLARHQRIHTGEKPHACDTCGHRFRNSSNLARHRRSHTGERPYSCQTCGRSFRRNAHLRRHLATHAEPGQEQAEPPQECVECGKSFSRSCNLLRHLLVHTGARPYSCTQCGRSFSRNSHLLRHLRTHARETLY"},{"id":"SEQ_00322","a":"Q8IWN7","g":"RP1L1","d":"Retinitis pigmentosa 1-like 1 protein","L":2400,"m":[{"c":"PEx-[GD][VIA]EA[PQ]-AE[GE]EAQ","u":16,"sp":"tandem","x":"disordered_like","cf":"high","why":"Large C-terminal disordered repeat array (residues 1846-2238) of 19 well-conserved 16-aa copies anchored by invariant N-terminal PE, conserved hydrophobic position 6 ([VIA]), acidic/alanine core positions, and C-terminal EAQ, arranged predominantly head-to-tail with occasional 7-aa half-repeat (EAEGEAQ) or truncated-unit insertions.","i":[[1846,1861,"PESEGVEAPEAEGDAQ"],[1869,1884,"PESEDVEAPEAEGEAQ"],[1885,1900,"PESEDVETPEAEWEVQ"],[1901,1916,"PESEGAEAPEAEKEAQ"],[1917,1932,"PETESVEALETEGEDE"],[1933,1948,"PESEGAEAQEAEEAAQ"],[1956,1971,"PESEVIESQEAEEEAQ"],[1972,1987,"PESEDVEALEVEVETQ"],[1995,2010,"PESEDVEAPEAEGEMQ"],[2050,2065,"PESDGVEAPEAEEEAQ"],[2080,2095,"PESEDVDAQEAEGEAQ"],[2096,2111,"PESEGVEAPEAEGEAQ"],[2127,2142,"PESEGIEAPEAEGEAQ"],[2143,2158,"PESEGVEAQDAEGEAQ"],[2159,2174,"PESEGIEAQEAEEEAQ"],[2175,2190,"PELEGVEAPEAEGEAQ"],[2191,2206,"PESEGIEAPEAEGEAQ"],[2207,2222,"PELEGVEAPEAEEEAQ"],[2223,2238,"PEPEGVETPEAEGEAQ"]]},{"c":"G[LQ]QEE[AGE][VA]QLEE[TIV][KE][ET][TEG]x","u":16,"sp":"tandem","x":"disordered_like","cf":"high","why":"Tandem 4-copy 16-aa repeat in the central acidic disordered region (residues 1315-1382, separated by 0-2 aa gaps and preceded by a divergent N-terminal variant TVQEEVQLEETKEGTEGE) defined by fixed GxQEE and QLEE anchors flanked by conserved aliphatic and charged/polar positions.","i":[[1314,1329,"GLQEEAVQLEETKTEE"],[1330,1345,"GLQEEGVQLEETKETE"],[1348,1363,"GQQEEEAQLEEIEETG"],[1366,1381,"GLQEEGVQLEEVKEGP"]]},{"c":"++IxφψKxxDPRφxxxxψφxHxxxxxxφ[SA]φL(x){15,17}TT(x){5,6}SLxAL(x){5,7}[CV]φψC","u":"68-71","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of an ~70-aa structured N-terminal domain (residues 34-104 and 152-219, separated by a 47-aa linker) sharing 14 identical anchor residues in conserved register (I, K, DPR, H, L, TT, SLxAL, and C-terminal C) alongside 11 conserved hydrophobic and basic core positions.","i":[[34,104,"KKITFLKRGDPRFAGVRLAVHQRAFKTFSALMDELSQRVPLSFGVRSVTTPRGLHSLSALEQLEDGGCYLC"],[152,219,"RRILLIKNMDPRLQQTVVLSHRNTRNLAAFLGKASDLLRFPVKQLYTTSGKKVDSLQALLHSPSVLVC"]]}],"s":"MNSTPRNAQAPSHRECFLPSVARTPSVTKVTPAKKITFLKRGDPRFAGVRLAVHQRAFKTFSALMDELSQRVPLSFGVRSVTTPRGLHSLSALEQLEDGGCYLCSDKKPPKTPSGPGRPQERNPTAQQLRDVEGQREAPGTSSSRKSLKTPRRILLIKNMDPRLQQTVVLSHRNTRNLAAFLGKASDLLRFPVKQLYTTSGKKVDSLQALLHSPSVLVCAGHEAFRTPAMKNARRSEAETLSGLTSRNKNGSWGPKTKPSVIHSRSPPGSTPRLPERPGPSNPPVGPAPGRHPQDTPAQSGPLVAGDDMKKKVRMNEDGSLSVEMKVRFHLVGEDTLLWSRRMGRASALTAASGEDPVLGEVDPLCCVWEGYPWGFSEPGVWGPRPCRVGCREVFGRGGQPGPKYEIWTNPLHASQGERVAARKRWGLAQHVRCSGLWGHGTAGRERCSQDSASPASSTGLPEGSEPESSCCPRTPEDGVDSASPSAQIGAERKAGGSLGEDPGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSASTGSHEGSSEWGGRPQGCPGKARAETSQQEASEGGDPASPALSLSSLRSDDLQAETQGQGTEQATGAAVTREPLVLGLSCSWDSEGASSTPSTCTSSQQGQRRHRSRASAMSSPSSPGLGRVAPRGHPRHSHYRKDTHSPLDSSVTKQVPRPPERRRACQDGSVPRYSGSSSSTRTQASGNLRPPSSGSLPSQDLLGTSSATVTPAVHSDFVSGVSPHNAPSAGWAGDAGSRTCSPAPIPPHTSDSCSKSGAASLGEEARDTPQPSSPLVLQVGRPEQGAVGPHRSHCCSQPGTQPAQEAQRGPSPEASWLCGRYCPTPPRGRPCPQRRSSSCGSTGSSHQSTARGPGGSPQEGTRQPGPTPSPGPNSGASRRSSASQGAGSRGLSEEKTLRSGGGPQGQEEASGVSPSSLPRSSPEAVVREWLDNIPEEPILMTYELADETTGAAGGGLRGPEVDPGDDHSLEGLGEPAQAGQQSLEGDPGQDPEPEGALLGSSDTGPQSGEGVPQGAAPEGVSEAPAEAGADREAPAGCRVSLRALPGRVSASTQIMRALMGSKQGRPSSVPEVSRPMARRLSCSAGALITCLASLQLFEEDLGSPASKVRFKDSPRYQELLSISKDLWPGCDVGEDQLDSGLWELTWSQALPDLGSHAMTENFTPTSSSGVDISSGSGGSGESSVPCAMDGTLVTQGTELPLKTSNQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASEGYDLQEDQALGSLAPTEAVGRADGFGQDDLDF"},{"id":"SEQ_00329","a":"O43313","g":"ATMIN","d":"ATM interactor","L":823,"m":[{"c":"[DSN]x[EQH]TQT","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Ten dispersed 6-residue copies across the C-terminal polar/acidic disordered region (residues 456-814) share an invariant TQT tripeptide preceded by [EQH] at -1 and strictly conserved [DSN] at -3.","i":[[456,461,"SVHTQT"],[490,495,"SRETQT"],[582,587,"DNQTQT"],[646,651,"NIQTQT"],[669,674,"DIETQT"],[701,706,"DTQTQT"],[737,742,"DTETQT"],[762,767,"STETQT"],[782,787,"SNETQT"],[808,813,"SVETQT"]]},{"c":"xxC(x){1,4}C(x){3,7}φxxxxxψxxH(x){3,5}[HC]","u":"23-30","sp":"dispersed","x":"structured_like","cf":"high","why":"Four structured 23-30 aa repeats in the N-terminal region (residues 84-214) are anchored by paired Cys residues, a conserved core with hydrophobic (L/F/Y) and aliphatic (L/V) positions at fixed offsets (-9 and -3), and paired His/[HC] anchors.","i":[[84,109,"ILCTVRGCGKILPNSPALNMHLVKSH"],[131,160,"YCCPIEGCPRGPERPFSQFSLVKQHFMKMH"],[165,187,"HKCSKCSNSYGTEWDLKRHAEDC"],[191,214,"FRCTCGCPYASRTALQSHIYRTGH"]]}],"s":"MAASEAAAAAGSAALAAGARAVPAATTGAAAAASGPWVPPGPRLRGSRPRPAGATQQPAVPAPPAGELIQPSVSELSRAVRTNILCTVRGCGKILPNSPALNMHLVKSHRLQDGIVNPTIRKDLKTGPKFYCCPIEGCPRGPERPFSQFSLVKQHFMKMHAEKKHKCSKCSNSYGTEWDLKRHAEDCGKTFRCTCGCPYASRTALQSHIYRTGHEIPAEHRDPPSKKRKMENCAQNQKLSNKTIESLNNQPIPRPDTQELEASEIKLEPSFEDSCGSNTDKQTLTTPPRYPQKLLLPKPKVALVKLPVMQFSVMPVFVPTADSSAQPVVLGVDQGSATGAVHLMPLSVGTLILGLDSEACSLKESLPLFKIANPIAGEPISTGVQVNFGKSPSNPLQELGNTCQKNSISSINVQTDLSYASQNFIPSAQWATADSSVSSCSQTDLSFDSQVSLPISVHTQTFLPSSKVTSSIAAQTDAFMDTCFQSGGVSRETQTSGIESPTDDHVQMDQAGMCGDIFESVHSSYNVATGNIISNSLVAETVTHSLLPQNEPKTLNQDIEKSAPIINFSAQNSMLPSQNMTDNQTQTIDLLSDLENILSSNLPAQTLDHRSLLSDTNPGPDTQLPSGPAQNPGIDFDIEEFFSASNIQTQTEESELSTMTTEPVLESLDIETQTDFLLADTSAQSYGCRGNSNFLGLEMFDTQTQTDLNFFLDSSPHLPLGSILKHSSFSVSTDSSDTETQTEGVSTAKNIPALESKVQLNSTETQTMSSGFETLGSLFFTSNETQTAMDDFLLADLAWNTMESQFSSVETQTSAEPHTVSNF"},{"id":"SEQ_00330","a":"Q9UQQ2","g":"SH2B3","d":"SH2B adapter protein 3","L":575,"m":[{"c":"[SG]LPH[WL]xS[ES]","u":8,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three tandem 8-residue repeats in the C-terminal proline/serine-rich region (residues 480-504, separated by 0 and 1 aa) share an invariant LPH tripeptide core flanked by [SG] at position 1, hydrophobic [WL] at position 5, and S[ES] at positions 7-8.","i":[[480,487,"SLPHWDSE"],[488,495,"SLPHWGSE"],[497,504,"GLPHLSSS"]]}],"s":"MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARSSEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAKKFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELFDPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL"},{"id":"SEQ_00368","a":"Q5TAG4","g":"NBPF12","d":"NBPF family member NBPF12","L":1457,"m":[{"c":"MVVSAGP[WL]SSEKAEMNILEINEKLRPQLAE[NK]KQQFR[NS]LKE+CF[LV]TQ[LV]A[GC]FLA[NK][RQ]Q[KN]KYKYEECKDL[IL]K[FS]MLRNE[RL]QFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQ[QH]LVQKLSPEND[EN]D-DEDVQVE[EV][DA]EKV[LQ][EK]SS[AS]PRE[VM]QKAEE[SK][KE]VPEDSLEECAITCSNSHGP[CY]DS[IN]QPH+[NK][IT]KITFEEDKV[ND]S[TS][VL][VI][VG](x){0,2}xSSH[DV]E[CW][QE]DA[LV][NH]I[LI]","u":"256-258","sp":"periodic","x":"mixed","cf":"high","why":"Three large, highly conserved (~90% identity) N-terminal domain duplications of 256-258 aa separated by identical 13-aa linkers (PVPGPTSSATNVS), each combining helical/coiled-coil and structured C-terminal segments with an internal acidic loop.","i":[[1,258,"MVVSAGPWSSEKAEMNILEINEKLRPQLAENKQQFRNLKERCFLTQLAGFLANRQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSTVVVDRKSSHDECQDALNIL"],[272,529,"MVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRSLKEKCFVTQLAGFLAKQQNKYKYEECKDLIKSMLRNELQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSSPREMQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDKVNSSLVVDRESSHDECQDALNIL"],[543,798,"MVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLLKSMLRNELQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHII"]]},{"c":"[GC]P[RV][LS]x[RS]xLx[AE]xxE[PE]EV[LP]Q-S[LW]D[RE][CGW]YST[PL]Sx[YCP][LPF][EG][LQR][PTL][DA]xxQ[PSH]Y[RS]Sx[FV][YH][SVA][LF]E[EQ][QK]xψ[GCT]φ[AS][LV]Dψ[DG]","u":60,"sp":"dispersed","x":"structured_like","cf":"high","why":"Eight non-overlapping 60-aa C-terminal domain repeats (an initial divergent copy followed by seven tightly conserved copies including a duplicated 3-repeat block) anchored by [GC]P, EV[LP]Q-S[LW]D, YST[PL]S, Q[PSH]Y[RS]S, and a hydrophobic C-terminal core ending in ψ[AS][LV]Dψ[DG], separated by 15-aa or 34-aa charged linkers.","i":[[812,871,"GPVSPRNLQESEEEEVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIG"],[887,946,"GPRLSRELLAEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRVGLAVDMD"],[962,1021,"CPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD"],[1037,1096,"CPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYRSSFYALEEKHVGFSLDVG"],[1131,1190,"CPRLSRELLAEKEPEVLQDSLDRWYSTPSVYLGLTDPCQPYRSAFYVLEQQRVGLAVDMD"],[1206,1265,"CPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD"],[1281,1340,"CPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYRSSFYALEEKHVGFSLDVG"],[1375,1434,"CPRLNSVLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHITFALDMD"]]}],"s":"MVVSAGPWSSEKAEMNILEINEKLRPQLAENKQQFRNLKERCFLTQLAGFLANRQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQQLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIKITFEEDKVNSTVVVDRKSSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRSLKEKCFVTQLAGFLAKQQNKYKYEECKDLIKSMLRNELQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSSPREMQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDKVNSSLVVDRESSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRSLKEKCFVTQVACFLAKQQNKYKYEECKDLLKSMLRNELQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLAEKEPEVLQDSLDRCYSTPSVYLGLTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYRSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKKRRRGRKEGEEDQNPPCPRLSRELLAEKEPEVLQDSLDRWYSTPSVYLGLTDPCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYRSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKKRRRGRKEGEEDQNPPCPRLNSVLMEVEEPEVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHITFALDMDNSFFTLTVTSLHLVFQMGVIFPQ"},{"id":"SEQ_00384","a":"P26436","g":"ACRV1","d":"Acrosomal protein SP-10","L":265,"m":[{"c":"[GS]E[HQ][PAG]S","u":5,"sp":"tandem","x":"disordered_like","cf":"high","why":"Contiguous head-to-tail tandem array of 22 pentapeptide repeats (residues 66-175) in a disordered central region, strongly anchored by invariant-like E at position 2, H/Q at position 3, G/S at position 1, P/A/G at position 4, and S at position 5.","i":[[66,70,"SEHGS"],[71,75,"SEHGS"],[76,80,"SKHTV"],[81,85,"AEHTS"],[86,90,"GEHAE"],[91,95,"SEHAS"],[96,100,"GEPAA"],[101,105,"TEHAE"],[106,110,"GEHTV"],[111,115,"GEQPS"],[116,120,"GEQPS"],[121,125,"GEHLS"],[126,130,"GEQPL"],[131,135,"SELES"],[136,140,"GEQPS"],[141,145,"DEQPS"],[146,150,"GEHGS"],[151,155,"GEQPS"],[156,160,"GEQAS"],[161,165,"GEQPS"],[166,170,"GEHAS"],[171,175,"GEQAS"]]}],"s":"MNRFLLLMSLYLLGSARGTSSQPNELSGSIDHQTSVQQLPGEFFSLENPSDAEALYETSSGLNTLSEHGSSEHGSSKHTVAEHTSGEHAESEHASGEPAATEHAEGEHTVGEQPSGEQPSGEHLSGEQPLSELESGEQPSDEQPSGEHGSGEQPSGEQASGEQPSGEHASGEQASGAPISSTSTGTILNCYTCAYMNDQGKCLRGEGTCITQNSQQCMLKKIFEGGKLQFMVQGCENMCPSMNLFSHGTRMQIICCRNQSFCNKI"},{"id":"SEQ_00393","a":"Q8N7X4","g":"MAGEB6","d":"Melanoma-associated antigen B6","L":407,"m":[{"c":"D[AV]S[IV]PQESQG[AV]SPTGSPDA[GV]VS[GY]SK[SY]DVAA[NE]G[QE]DE[KE]S[PV]S[TA]S[RHQ]","u":42,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three highly conserved 42-residue head-to-tail tandem repeats (residues 57-182) in an N-terminal disordered region, sharing 29 invariant positions including fixed PQESQG, SPTGSPDA, and DVAA cores.","i":[[57,98,"DASIPQESQGVSPTGSPDAVVSYSKSDVAANGQDEKSPSTSR"],[99,140,"DASVPQESQGASPTGSPDAGVSGSKYDVAANGQDEKSPSTSH"],[141,182,"DVSVPQESQGASPTGSPDAGVSGSKYDVAAEGEDEESVSASQ"]]}],"s":"MPRGHKSKLRTCEKRQETNGQPQGLTGPQATAEKQEESHSSSSSSRACLGDCRRSSDASIPQESQGVSPTGSPDAVVSYSKSDVAANGQDEKSPSTSRDASVPQESQGASPTGSPDAGVSGSKYDVAANGQDEKSPSTSHDVSVPQESQGASPTGSPDAGVSGSKYDVAAEGEDEESVSASQKAIIFKRLSKDAVKKKACTLAQFLQKKFEKKESILKADMLKCVRREYKPYFPQILNRTSQHLVVAFGVELKEMDSSGESYTLVSKLGLPSEGILSGDNALPKSGLLMSLLVVIFMNGNCATEEEVWEFLGLLGIYDGILHSIYGDARKIITEDLVQDKYVVYRQVCNSDPPCYEFLWGPRAYAETTKMRVLRVLADSSNTSPGLYPHLYEDALIDEVERALRLRA"},{"id":"SEQ_00417","a":"O14776","g":"TCERG1","d":"Transcription elongation regulator 1","L":1098,"m":[{"c":"F[KRF]x[LM][LM](x){20,30}DxRx(x){11,14}[FI]x[QEA][YFH][VI]","u":"45-57","sp":"dispersed","x":"structured_like","cf":"high","why":"Six C-terminal ~45-57 aa globular repeat units anchored by an invariant N-terminal F[KRF]x[LM][LM] motif, a central invariant D-x-R-x turn motif (mostly DPRY/DSRF/DHRW/DKRY), and a conserved C-terminal [FI]x[QEA][YFH][VI] hydrophobic-aromatic cap separated by variable linkers including a charged helical rod between copies 3 and 4.","i":[[666,710,"FKDMLLERGVSAFSTWEKELHKIVFDPRYLLLNPKERKQVFDQYV"],[732,777,"FKKMMEEAKFNPRATFSEFAAKHAKDSRFKAIEKMKDREALFNEFV"],[799,844,"FFELLSNHHLDSQSRWSKVKDKVESDPRYKAVDSSSMREDLFKQYI"],[903,950,"FKALLSDMVRSSDVSWSDTRRTLRKDHRWESGSLLEREEKEKLFNEHI"],[961,1008,"FRQLLDETSAITLTSTWKEVKKIIKEDPRCIKFSSSDRKKQREFEEYI"],[1019,1075,"FRTLLKETKFITYRSKKLIQESDQHLKDVEKILQNDKRYLVLDCVPEERRKLIVAYV"]]},{"c":"Wx[EV]x[KW]T[PAG]D[GE]+[VT]ΩΩYNx[RT]T[RL][EL]SxWx+P[DQ]xψ","u":29,"sp":"dispersed","x":"structured_like","cf":"high","why":"Three ungapped 29-aa dispersed structured repeats anchored by two invariant tryptophans spaced 22 residues apart, a central aromatic-polar ΩΩYN core, invariant T6/D8/T18/S21/P26 positions, and a C-terminal +P[DQ]xψ motif.","i":[[137,165,"WVENKTPDGKVYYYNARTRESAWTKPDGV"],[435,463,"WTEYKTADGKTYYYNNRTLESTWEKPQEL"],[534,562,"WCVVWTGDERVFFYNPTTRLSMWDRPDDL"]]}],"s":"MAERGGDGGESERFNPGELRMAQQQALRFRGPAPPPNAVMRGPPPLMRPPPPFGMMRGPPPPPRPPFGRPPFDPNMPPMPPPGGIPPPMGPPHLQRPPFMPPPMSSMPPPPGMMFPPGMPPVTAPGTPALPPTEEIWVENKTPDGKVYYYNARTRESAWTKPDGVKVIQQSELTPMLAAQAQVQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQVQAQVQAQVQAQAVGASTPTTSSPAPAVSTSTSSSTPSSTTSTTTTATSVAQTVSTPTTQDQTPSSAVSVATPTVSVSTPAPTATPVQTVPQPHPQTLPPAVPHSVPQPTTAIPAFPPVMVPPFRVPLPGMPIPLPGVAMMQIVSCPYVKTVATTKTGVLPGMAPPIVPMIHPQVAIAASPATLAGATAVSEWTEYKTADGKTYYYNNRTLESTWEKPQELKEKEKLEEKIKEPIKEPSEEPLPMETEEEDPKEEPIKEIKEEPKEEEMTEEEKAAQKAKPVATAPIPGTPWCVVWTGDERVFFYNPTTRLSMWDRPDDLIGRADVDKIIQEPPHKKGMEELKKLRHPTPTMLSIQKWQFSMSAIKEEQELMEEINEDEPVKAKKRKRDDNKDIDSEKEAAMEAEIKAARERAIVPLEARMKQFKDMLLERGVSAFSTWEKELHKIVFDPRYLLLNPKERKQVFDQYVKTRAEEERREKKNKIMQAKEDFKKMMEEAKFNPRATFSEFAAKHAKDSRFKAIEKMKDREALFNEFVAAARKKEKEDSKTRGEKIKSDFFELLSNHHLDSQSRWSKVKDKVESDPRYKAVDSSSMREDLFKQYIEKIAKNLDSEKEKELERQARIEASLREREREVQKARSEQTKEIDREREQHKREEAIQNFKALLSDMVRSSDVSWSDTRRTLRKDHRWESGSLLEREEKEKLFNEHIEALTKKKREHFRQLLDETSAITLTSTWKEVKKIIKEDPRCIKFSSSDRKKQREFEEYIRDKYITAKADFRTLLKETKFITYRSKKLIQESDQHLKDVEKILQNDKRYLVLDCVPEERRKLIVAYVDDLDRRGPPPPPTASEPTRRSTK"},{"id":"SEQ_00419","a":"Q9NZC9","g":"SMARCAL1","d":"SNF2 related chromatin remodeling annealing helicase 1","L":954,"m":[{"c":"-LIAψFKoψxS+xYDxxT+xWoFxψx-[HY]SxLψxxφxxLPoVoLxPL","u":46,"sp":"dispersed","x":"structured_like","cf":"high","why":"Strongly conserved 46-aa internal domain duplication (residues 259-304 and 352-397) separated by a 47-aa linker, anchored by identical LIAxFK, YD, WxF, and LPoVoLxPL motifs plus conserved hydrophobic and charged positions.","i":[[257,302,"ELIAVFKTLPSKNYDPDTKTWNFSMNDYSALMKAAQSLPTVNLQPL"],[352,397,"DLIALFKQMDSRRYDVKTRKWSFLLEEHSKLIAKVRCLPQVQLDPL"]]}],"s":"MSLPLTEEQRKKIEENRQKALARRAEKLLAEQHQRTSSGTSIAGNPFQAKQGPSQNFPRESCKPVSHGVIFKQQNLSSSSNADQRPHDSHSFQAKGIWKKPEEMPTACPGHSPRSQMALTGISPPLAQSPPEVPKQQLLSYELGQGHAQASPEIRFTPFANPTHKPLAKPKSSQETPAHSSGQPPRDAKLEAKTAKASPSGQNISYIHSSSESVTPRTEGRLQQKSGSSVQKGVNSQKGKCVRNGDRFQVLIGYNAELIAVFKTLPSKNYDPDTKTWNFSMNDYSALMKAAQSLPTVNLQPLEWAYGSSESPSTSSEGQAGLPSAPSLSFVKGRCMLISRAYFEADISYSQDLIALFKQMDSRRYDVKTRKWSFLLEEHSKLIAKVRCLPQVQLDPLPTTLTLAFASQLKKTSLSLTPDVPEADLSEVDPKLVSNLMPFQRAGVNFAIAKGGRLLLADDMGLGKTIQAICIAAFYRKEWPLLVVVPSSVRFTWEQAFLRWLPSLSPDCINVVVTGKDRLTAGLINIVSFDLLSKLEKQLKTPFKVVIIDESHFLKNSRTARCRAAMPVLKVAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRMPWGWDYSGSSNLGELKLLLEEAVMLRRLKSDVLSQLPAKQRKIVVIAPGRINARTRAALDAAAKEMTTKDKTKQQQKDALILFFNRTAEAKIPSVIEYILDLLESGREKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQLSERHAVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTADDYLWPLIQEKIKVLAEAGLSETNFSEMTESTDYLYKDPKQQKIYDLFQKSFEKEGSDMELLEAAESFDPGSASGTSGSSSQNMGDTLDESSLTASPQKKRRFEFFDNWDSFTSPL"},{"id":"SEQ_00434","a":"Q6ZS11","g":"RINL","d":"Ras and Rab interactor-like protein","L":566,"m":[{"c":"P[GA]PALx[ST]","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 7-aa copies located in proline/glycine-rich disordered linkers (residues 224-230, 341-347, and 402-408), sharing a conserved P[GA]PAL core flanked by a C-terminal [ST] position.","i":[[224,230,"PGPALAS"],[341,347,"PGPALET"],[402,408,"PAPALRS"]]}],"s":"MAQPEDKAPEVPTEGVRLVPPQVNKADRTPLGVLSTLEPLTRLQRTWGVWHVPELDTQDAEALVGLWPLGSFLVTGRDPSQALVLRSGPLPGEVNTYQIQKIPRGVSLESSNLCMPDLPHLLAFLSASRDVLPRTLLLPPPTLGPRDEHTDPVQIGRVQQDTPGKVLSIVNQLYLETHRGWGREQTPQETEPEAAQRHDPAPRNPAPHGVSWVKGPLSPEVDHPGPALASLLEEEEEDLEGKEEGREDDPEEEGPEDVLTIHVQSLVRARSSYVARQYRSLRVRIASDSGGPHGSGDPATELLQDVRHLLTDLQDHLAKDSYIRAVFGSRGPGLPKKDEDPGPALETAVCQAVLAPLKPALWTRLRTLRAPELRRLRRRQTALRAGAGPPGAQGPGPEGQSPAPALRSRIHERLAHLHAACAPRRKVALLLEVCRDVYAGLARGENQDPLGADAFLPALTEELIWSPDIGDTQLDVEFLMELLDPDELRGEAGYYLTTWFGALHHIAHYQPETDRAPRGLSSEARASLHQWHRRRTLHRKDHPRAQANLPFKEPWAEETVTGTSDN"},{"id":"SEQ_00441","a":"Q9NZP6","g":"NPAP1","d":"Nuclear pore-associated protein 1","L":1156,"m":[{"c":"ATPQPKFxAPDGxxK[AT]SLPSAxxFLSLPIψxPPDTSTLVoSAS[TA]ASxSKP[PA]I-ToxMxTTPPSK[AT]VILQS[AT]xVS+K(x){0,2}YψxFYψGLPGSGNTxxSxo[TI]ASφQxSTSφPAQ[SA]xRxP[AT]T[AT]SoHPLN[PT]G","u":"125-127","sp":"tandem","x":"mixed","cf":"high","why":"Large 125-127 aa head-to-tail tandem duplication sharing ~68% sequence identity across its full length, anchored by conserved ATPQPKFxAPDG, FLSLPI, PPDTSTLV, TPPSK[AT]VILQ, YψxFYψGLPGSGNT, and HPLN[PT]G segments with a 2-residue internal insertion.","i":[[643,767,"ATPQPKFEAPDGQPQKASLPSACVFLSLPIIPPPDTSTLVNSASTASSSKPPIETNAMHTTPPSKAVILQSASVSKKYLPFYLGLPGSGNTQPSGNTASVQGSTSLPAQSVRAPATASNHPLNPG"],[768,894,"ATPQPKFGAPDGPQQKTSLPSAHDFLSLPIMVPPDTSTLVSSASAASLSKPAIDTSDMNTTPPSKTVILQSTFVSRKEEYIRFYMGLPGSGNTLHSDSIASAQVSTSFPAQADRRPTTTSSHPLNTG"]]}],"s":"MGNLLSKFRPGCRRRPLPGPGRGAPAPLSRDASPPGRAHSVPTPRPFRGLFRRNARRRPSAASIFVAPKRPCPLPRAAAAPLGVLPAVGWGLAIRKTPMLPARNPPRFGHPSSVRIPPPSRMFTLLLPSPREPAVKARKPIPATLLEETEVWAQEGPRRVKKDEDPVQIEGEDDEKRTPLSSGEASSTSRSQGTQGDVASFRCSPGPLEGNVYHKFSENSMSEKAQASPASSCLEGPAMPSTHSQAGCARHLGKPDPDATAPPEPAVGCSLLQQKLAAEVLNEEPPPSSLGLPIPLMSGKRMPDEKPFCIPPRSAAPPRAARNRPCKRKMSIPLLLPLPPSLPLLWDRGELPPPAKLPCLSVEGDLHTLEKSPEYKRNSRILEDKTETMTNSSITQPAPSFSQPVQTTDSLPLTTYTSQVSAPLPIPDLADLATGPLILPIPPLSTTPKMDEKIAFTIPNSPLALPADLVPILGDQSNEKGGSYNSVVGAAPLTSDPPTPPSSTPSFKPPVTRESPISMCVDSPPPLSFLTLLPVPSTGTSVITSKPMNSTSVISTVTTNASAHLTSQTAVDPEVVNMDTTAPSQVVIFTSSLSSRVSSLPNSQIHCSAEQRHPGKTSVYTSPLPFIFHNTTPSFNQLFGKEATPQPKFEAPDGQPQKASLPSACVFLSLPIIPPPDTSTLVNSASTASSSKPPIETNAMHTTPPSKAVILQSASVSKKYLPFYLGLPGSGNTQPSGNTASVQGSTSLPAQSVRAPATASNHPLNPGATPQPKFGAPDGPQQKTSLPSAHDFLSLPIMVPPDTSTLVSSASAASLSKPAIDTSDMNTTPPSKTVILQSTFVSRKEEYIRFYMGLPGSGNTLHSDSIASAQVSTSFPAQADRRPTTTSSHPLNTGSISHSTLGATDGQQKSDSSFILGNPATPAPVIGLTSPSVQPLSGSIIPPGFAELTSPYTALGTPVNAEPVEGHNASAFPNGTAKTSGFRIATGMPGTGDSTLLVGNTIPGPQVIMGPGTPMDGGSIGFSMSAPGPSSTSGELNIGQGQSGTPSTTSVFPFGQAAWDPTGHSMAAAPQGASNIPVFGYTSAAAYIPGLDPPTQNSCSGMGGDGTRSIVGGPCVPAFQQCILQHTWTERKFYTSSTHYYGQETYVRRHVCFQLP"},{"id":"SEQ_00444","a":"P0C6C1","g":"ANKRD34C","d":"Ankyrin repeat domain-containing protein 34C","L":535,"m":[{"c":"xoxxxxxGx[ST][AL]Lxx[AV]x(x){5,14}φ[TVL][KRS][LYH]LL-xx[AK]x","u":"32-41","sp":"tandem","x":"structured_like","cf":"high","why":"Four head-to-tail tandem 32-41 aa structural repeats defined by a conserved Gx[ST][AL]Lxx[AV] first segment and φ[TVL][KRS][LYH]LL-xx[AK] second segment separated by a variable 5-14 residue internal loop.","i":[[5,36,"DTELRTDGNSLLKAVWLGRLRLTRLLLEGGAY"],[37,77,"INESNDKGETALMVACITKHVDQQSISKSKMVKYLLDNRAD"],[78,111,"PNIQDKSGKTALIHACIRRAGGEVVSLLLENGAD"],[112,144,"PSLEDRTGASALVYAINADDKDALKHLLDACKA"]]}],"s":"MMDDDTELRTDGNSLLKAVWLGRLRLTRLLLEGGAYINESNDKGETALMVACITKHVDQQSISKSKMVKYLLDNRADPNIQDKSGKTALIHACIRRAGGEVVSLLLENGADPSLEDRTGASALVYAINADDKDALKHLLDACKAKGKEVIIITTDKSSSGTKTTKQYLNVPPSPKVEDRHSPPLCASPSDIELKALGLDSPLTEKEDDFFSLQAGHPSSCNTSKAVNEPGSPTRKVSNLKRARLPQLKRLQSEPWGLIAPSVLAASTRQDETHGASTDNEVIKSISDISFPKRGPLSRTNSIDSKDPTLFHTVTEQVLKIPVSSAPASWKAAYEKGQAPHPRLARRGTLPVDQEKCGMGPSGPSALKEPASLKWLENDLYDLDIQPGPDPPNSISLESGKGPLDRKKLNSSHLSLFHGSRESLDTVPSTSPSSARRRPPHLLERRGSGTLLLDRISHTRPGFLPPLNVNLNPPIPDIRSSSKPSCSLASGLKSMVPVAPSSPKRVDLRSKKKLLRRHSMQIEQMKQLSDFEEIMT"},{"id":"SEQ_00449","a":"Q17R98","g":"ZNF827","d":"Zinc finger protein 827","L":1081,"m":[{"c":"[FYH](x){1,2}CxxCxxxxxxxxxφxxH(x){3,4}H","u":"23-26","sp":"dispersed","x":"structured_like","cf":"high","why":"Nine structured repeats distributed across three clusters share an N-terminal [FYH] anchor, invariant CxxC and C-terminal H(x){3,4}H pairs separated by a 12-residue segment containing a strictly conserved hydrophobic residue two positions before the first His.","i":[[374,396,"FQCPICGLVIKRKSYWKRHMVIH"],[402,424,"HQCPLCPFRCARKDNLKSHMKVH"],[433,455,"FQCQLCPFTSSRHFSLKLHMRCH"],[817,839,"FPCDVCGKVFGRQQTLSRHLSLH"],[845,867,"YKCHLCPYAAKCRANLNQHLTVH"],[897,919,"YSCHVCGFETELNVQFVSHMSLH"],[927,952,"FSICCTACDFVTMEEAEIKTHIGTKH"],[1019,1041,"FECVFCNFVCKTKNMFERHLQIH"],[1047,1069,"FECDVCHKFMKTPEQLLEHKKCH"]]},{"c":"[LV][FL][SR][QR]D[IV]SVK[MA]AS-[FL]L[MF][KQ]LS[AE]xxxKE","u":25,"sp":"periodic","x":"mixed","cf":"high","why":"Three highly conserved 25-residue amphipathic motifs in the central region share invariant D, S, V, K, A, S, L, L, S, K, E anchors and tightly constrained hydrophobic/polar positions separated by regular ~53-55 aa linkers.","i":[[564,588,"LFSQDISVKMASDFLMKLSAANQKE"],[642,666,"VLRRDVSVKAASELLMKLSAESYKE"],[722,746,"LFSQDISVKMASELLFQLSEKVSKE"]]},{"c":"[LFV][KL][VI]KEEP[KM]E","u":9,"sp":"periodic","x":"disordered_like","cf":"high","why":"Three non-overlapping 9-residue disordered motifs in the central linker share an invariant KEEP...E core flanked by a conserved N-terminal hydrophobic-basic/aliphatic triad ([LFV][KL][VI]) at regular ~65-67 aa intervals.","i":[[520,528,"LLVKEEPKE"],[594,602,"FKVKEEPKE"],[670,678,"VKIKEEPME"]]}],"s":"MPRRKQEQPKRLPSHVSRQEEAEGELSEGEHWYGNSSETPSEASYGEVQENYKLSLEDRIQEQSTSPDTSLGSTTPSSHTLELVALDSEVLRDSLQCQDHLSPGVSSLCDDDPGSNKPLSSNLRRLLEAGSLKLDAAATANGRVESPVNVGSNLSFSPPSHHAQQLSVLARKLAEKQEQNDQYTPSNRFIWNQGKWLPNSTTTCSLSPDSAILKLKAAANAVLQDKSLTRTEETMRFESFSSPFSSQSASSTLAALSKKVSERSLTPGQEHPPPASSFLSLASMTSSAALLKEVAARAAGSLLAEKSSLLPEDPLPPPPSEKKPEKVTPPPPPPPPPPPPPPPQSLELLLLPVPKGRVSKPSNSASEEESGKPFQCPICGLVIKRKSYWKRHMVIHTGLKSHQCPLCPFRCARKDNLKSHMKVHQHQDRGETFQCQLCPFTSSRHFSLKLHMRCHQHFLRTEAKVKEEIPDPDVKGSPHLSDSACLGQQREGGGTELVGTMMTSNTPERTSQGGAGVSPLLVKEEPKEDNGLPTSFTLNAADRPANHTKLKDPSEYVANSASALFSQDISVKMASDFLMKLSAANQKEPMNLNFKVKEEPKEGESLSTTLPRSSYVFSPESEVSAPGVSEDALKPQEGKGSVLRRDVSVKAASELLMKLSAESYKETQMVKIKEEPMEVDIQDSHVSISPSRNVGYSTLIGREKTEPLQKMPEGRVPPERNLFSQDISVKMASELLFQLSEKVSKEHNHTKENTIRTTTSPFFSEDTFRQSPFTSNSKELLPSDSVLHGRISAPETEKIVLEAGNGLPSWKFNDQLFPCDVCGKVFGRQQTLSRHLSLHTEERKYKCHLCPYAAKCRANLNQHLTVHSVKLVSTDTEDIVSAVTSEGSDGKKHPYYYSCHVCGFETELNVQFVSHMSLHVDKEQWMFSICCTACDFVTMEEAEIKTHIGTKHTGEDRKTPSESNSPSSSSLSALSDSANSKDDSDGSQKNKGGNNLLVISVMPGSQPSLNSEEKPEKGFECVFCNFVCKTKNMFERHLQIHLITRMFECDVCHKFMKTPEQLLEHKKCHTVPTGGLNSGQW"},{"id":"SEQ_00454","a":"Q96IF1","g":"AJUBA","d":"LIM domain-containing protein ajuba","L":538,"m":[{"c":"CxxC(x){15,22}YHxxC[FY]xCxxC(x){15,18}[VL][YL]Cxx[DC][YH]","u":"53-62","sp":"periodic","x":"structured_like","cf":"high","why":"Three C-terminal structured modules separated by short 7-11 aa linkers each combine an N-terminal CxxC pair, an invariant central YHxxC[FY]xCxxC bridge, and a C-terminal [VL][YL]Cxx[DC][YH] signature.","i":[[338,391,"CIKCNKGIYGQSNACQALDSLYHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDY"],[403,455,"CCVCGHLILEKILQAMGKSYHPGCFRCIVCNKCLDGIPFTVDFSNQVYCVTDY"],[463,524,"CAACGQPILPSEGCEDIVRVISMDRDYHFECYHCEDCRMQLSDEEGCCCFPLDGHLLCHGCH"]]},{"c":"[RN]xxGS[LF][DEP]A","u":8,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three tandem 8-residue disordered repeats separated by 1-2 aa gaps in the N-terminal tail share invariant GS and C-terminal A anchors, a conserved bulky hydrophobic [LF] position, and constrained [RN] and [DEP] flanking choices.","i":[[65,72,"REQGSLDA"],[75,82,"NQRGSFEA"],[84,91,"RYEGSFPA"]]}],"s":"MERLGEKASRLLEKFGRRKGESSRSGSDGTPGPGKGRLSGLGGPRKSGPRGATGGPGDEPLEPAREQGSLDAERNQRGSFEAPRYEGSFPAGPPPTRALPLPQSLPPDFRLEPTAPALSPRSSFASSSASDASKPSSPRGSLLLDGAGAGGAGGSRPCSNRTSGISMGYDQRHGSPLPAGPCLFGPPLAGAPAGYSPGGVPSAYPELHAALDRLYAQRPAGFGCQESRHSYPPALGSPGALAGAGVGAAGPLERRGAQPGRHSVTGYGDCAVGARYQDELTALLRLTVGTGGREAGARGEPSGIEPSGLEEPPGPFVPEAARARMREPEAREDYFGTCIKCNKGIYGQSNACQALDSLYHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDYLFSGFQEAAEKCCVCGHLILEKILQAMGKSYHPGCFRCIVCNKCLDGIPFTVDFSNQVYCVTDYHKNYAPKCAACGQPILPSEGCEDIVRVISMDRDYHFECYHCEDCRMQLSDEEGCCCFPLDGHLLCHGCHMQRLNARQPPANYI"},{"id":"SEQ_00457","a":"P10451","g":"SPP1","d":"Osteopontin","L":314,"m":[{"c":"E[TF]HSH","u":5,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three 5-residue disordered motifs (one upstream copy and two head-to-tail tandem copies) share four invariant positions (E, H, S, H) with a constrained [TF] second position, distinct from the unanchored D/S/E acidic low-complexity tract.","i":[[236,240,"ETHSH"],[272,276,"EFHSH"],[277,281,"EFHSH"]]}],"s":"MRIAVICFCLLGITCAIPVKQADSGSSEEKQLYNKYPDAVATWLNPDPSQKQNLLAPQNAVSSEETNDFKQETLPSKSNESHDHMDDMDDEDDDDHVDSQDSIDSNDSDDVDDTDDSHQSDESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRGDSVVYGLRSKSKKFRRPDIQYPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSRLYKRKANDESNEHSDVIDSQELSKVSREFHSHEFHSHEDMLVVDPKSKEEDKHLKFRISHELDSASSEVN"},{"id":"SEQ_00479","a":"P30203","g":"CD6","d":"T-cell differentiation antigen CD6","L":668,"m":[{"c":"CxGxVE[VM]xxx[AG]xWxx[AV]C[GD]xxW[DY]xxxAx[AV][VL]C[RQ]xLGCGxA[EV]x[AR]x(x){14,33}C[SN]G[AE]E(x){3,5}C(x){6,9}C(x){5,6}A[RG][VA][TVL]C[AS][EA]x[RQ][AS][LW][RH][LN][VTL]x[GT]xxx","u":"101-116","sp":"tandem","x":"structured_like","cf":"high","why":"Three head-to-tail tandem cysteine-rich globular domains (101-116 aa) sharing 8 invariant cysteines, conserved W/G/V/E/A/L core anchors in an ungapped 42-aa N-terminal segment, a variable internal loop, and a conserved C[SN]G[AE]E...A[RG][VA][TVL]C C-terminal module.","i":[[54,169,"CSGTVEVRLEASWEPACGALWDSRAAEAVCRALGCGGAEAASQLAPPTPELPPPPAAGNTSVAANATLAGAPALLCSGAEWRLCEVVEHACRSDGRRARVTCAENRALRLVDGGGA"],[170,273,"CAGRVEMLEHGEWGSVCDDTWDLEDAHVVCRQLGCGWAVQALPGLHFTPGRGPIHRDQVNCSGAEAYLWDCPGLPGQHYCGHKEDAGAVCSEHQSWRLTGGADR"],[274,374,"CEGQVEVHFRGVWNTVCDSEWYPSEAKVLCQSLGCGTAVERPKGLPHSLSGRMYYSCNGEELTLSNCSWRFNNSNLCSQSLAARVLCSASRSLHNLSTPEV"]]},{"c":"SSTSSGE[DW]YxN","u":11,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Two highly conserved 11-aa copies (9 of 11 identical positions, anchored by an identical SSTSSGE heptapeptide, conserved Y, and C-terminal N) separated by a 44-aa linker within the C-terminal Pro/Ser-rich disordered region.","i":[[564,574,"SSTSSGEDYCN"],[621,631,"SSTSSGEWYQN"]]}],"s":"MWLFFGITGLLTAALSGHPSPAPPDQLNTSSAESELWEPGERLPVRLTNGSSSCSGTVEVRLEASWEPACGALWDSRAAEAVCRALGCGGAEAASQLAPPTPELPPPPAAGNTSVAANATLAGAPALLCSGAEWRLCEVVEHACRSDGRRARVTCAENRALRLVDGGGACAGRVEMLEHGEWGSVCDDTWDLEDAHVVCRQLGCGWAVQALPGLHFTPGRGPIHRDQVNCSGAEAYLWDCPGLPGQHYCGHKEDAGAVCSEHQSWRLTGGADRCEGQVEVHFRGVWNTVCDSEWYPSEAKVLCQSLGCGTAVERPKGLPHSLSGRMYYSCNGEELTLSNCSWRFNNSNLCSQSLAARVLCSASRSLHNLSTPEVPASVQTVTIESSVTVKIENKESRELMLLIPSIVLGILLLGSLIFIAFILLRIKGKYALPVMVNHQHLPTTIPAGSNSYQPVPITIPKEVFMLPIQVQAPPPEDSDSGSDSDYEHYDFSAQPPVALTTFYNSQRHRVTDEEVQQSRFQMPPLEEGLEELHASHIPTANPGHCITDPPSLGPQYHPRSNSESSTSSGEDYCNSPKSKLPPWNPQVFSSERSSFLEQPPNLELAGTQPAFSAGPPADDSSSTSSGEWYQNFQPPPQPPSEEQFGCPGSPSPQPDSTDNDDYDDISAA"},{"id":"SEQ_00484","a":"Q92617","g":"NPIPB3","d":"Nuclear pore complex-interacting protein family member B3","L":1050,"m":[{"c":"SADDN[LI]KT[PR][PSA]E[CR][LVQ][LR][TGH][PA]LPP","u":19,"sp":"dispersed","x":"disordered_like","cf":"high","why":"20 highly conserved 19-aa repeats anchored by fixed SADDN, KT, E, and LPP positions in a proline/polar-rich disordered context, arranged in two arrays (residues 273-558 and 794-919) with 0, 4-aa (SAPP), or 8-aa (SALPSAPP) linkers around a central inserted repeat block.","i":[[277,295,"SADDNLKTPPECVLTPLPP"],[296,314,"SADDNLKTPPECVLTPLPP"],[315,333,"SADDNLKTPPECLLTPLPP"],[334,352,"SADDNLKTPPECLLTPLPP"],[361,379,"SADDNLKTRAECLLHPLPP"],[380,398,"SADDNLKTPSERQLTPLPP"],[403,421,"SADDNIKTPAERLRGPLPP"],[422,440,"SADDNLKTPSERQLTPLPP"],[445,463,"SADDNIKTPAERLRGPLPP"],[464,482,"SADDNLKTPSERQLTPLPP"],[487,505,"SADDNIKTPAERLRGPLPP"],[506,524,"SADDNLKTPSERQLTALPP"],[525,543,"SADDNIKTPAERLRGPLPP"],[544,562,"SADDNLKTPSERQLTPLPP"],[794,812,"SADDNLKTPSERQLTPLPP"],[817,835,"SADDNIKTPAERLRGPLPP"],[836,854,"SADDNLKTPSERQLTPLPP"],[859,877,"SADDNIKTPAERLRGPLPP"],[878,896,"SADDNLKTPSERQLTPLPP"],[901,919,"SADDNIKTPAERLRGPLPP"]]},{"c":"FHPQ[QR]MIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCG","u":40,"sp":"tandem","x":"mixed","cf":"high","why":"5 nearly identical 40-aa tandem repeats (39/40 positions invariant) separated by 2-aa GR linkers across residues 577-784, with each unit itself built from an internal duplication of [FL]HPQ[QR]MIISRHLPSV.","i":[[577,616,"FHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCG"],[619,658,"FHPQQMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCG"],[661,700,"FHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCG"],[703,742,"FHPQQMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCG"],[745,784,"FHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCG"]]},{"c":"PEPKRRRVGDVEPSRKPKRRRAADVEPS[SL]","u":29,"sp":"tandem","x":"disordered_like","cf":"high","why":"3 head-to-tail C-terminal 29-aa repeats (28/29 positions identical, residues 955-1041) in a basic/proline/acidic disordered tail, each composed of two internally duplicated [PR][EK]PKRRR[VA][GA]DVEPS half-units.","i":[[955,983,"PEPKRRRVGDVEPSRKPKRRRAADVEPSS"],[984,1012,"PEPKRRRVGDVEPSRKPKRRRAADVEPSS"],[1013,1041,"PEPKRRRVGDVEPSRKPKRRRAADVEPSL"]]}],"s":"MVKLSIVLTPQFLSHDQGQLTKELQQHVKSVTCPCEYLRKVINTLADHHHRGTDFGGSPWLHVIIAFPTSYKVVITLWIVYLWVSLLKTIFWSRNGHDGSTDVQQRAWRSNRRRQEGLRSICMHTKKRVSSFRGNKIGLKDVITLRRHVETKVRAKIRKRKVTTKINHHDKINGKRKTARKQKMFQRAQELRRRAEDYHKCKIPPSARKALCNWVRMAAAEHRHSSGLPYWPYLTAETLKNRMGHQPPPPTQQHSITDNSLSLKTPPECLLTPLPPSADDNLKTPPECVLTPLPPSADDNLKTPPECVLTPLPPSADDNLKTPPECLLTPLPPSADDNLKTPPECLLTPLPPSALPSAPPSADDNLKTRAECLLHPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTALPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAFHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQQMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQQMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPPLATQEAEAEKPRKPKRQRAAEMEPPPEPKRRRVGDVEPSRKPKRRRAADVEPSSPEPKRRRVGDVEPSRKPKRRRAADVEPSSPEPKRRRVGDVEPSRKPKRRRAADVEPSLPEPKRRRLS"},{"id":"SEQ_00486","a":"Q8TF61","g":"FBXO41","d":"F-box only protein 41","L":875,"m":[{"c":"[LI]xx[LV]xφ(x){10,18}φxxxC","u":"21-29","sp":"periodic","x":"structured_like","cf":"high","why":"6 consecutive structured repeats across residues 659-819 connected by short 2-6 aa turns, each anchored by an N-terminal [LI]xx[LV]xφ hydrophobic register and a C-terminal φxxxC cysteine motif.","i":[[659,683,"LLILRISHCPNILTDRSLWLASCYC"],[686,710,"LQAVTYRSATDPVGHEVIWALGAGC"],[713,741,"IVSLQVAPLHPCQQPTRFSNRCLQMIGRC"],[745,767,"LRALGVGGAGCGVQGLASLARNC"],[770,790,"LQVLELDHVSEITQEVAAEVC"],[797,819,"LEMLVLTATPVTPKALLHFNSIC"]]}],"s":"MASLDLPYRCPRCGEHKRFRSLSSLRAHLEYSHTYETLYILSKTNSICDGAAAAAAAAAAASGFPLAPEPAALLAVPGARREVFESTSFQGKEQAAGPSPAAPHLLHHHHHHAPLAHFPGDLVPASLPCEELAEPGLVPAAAARYALREIEIPLGELFARKSVASSACSTPPPGPGPGPCPGPASASPASPSPADVAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERADRAERQLQVISSSCGSTPSASLGRGGGGGGAGPNARGPGRMREHHVGPAVPNTYAVSRHGSSPSTGASSRVPAASQSSGCYDSDSLELPRPEEGAPEDSGPGGLGTRAQAANGGSERSQPPRSSGLRRQAIQNWQRRPRRHSTEGEEGDVSDVGSRTTESEAEGPLDAPRPGPAMAGPLSSCRLSARPEGGSGRGRRAERVSPSRSNEVISPEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVLLENARVCSKFLAMLAQWCTQAHSLTLQNLKPRQRGKKESKEEYARSTRGCLEAGLESLLKAAGGNLLILRISHCPNILTDRSLWLASCYCRALQAVTYRSATDPVGHEVIWALGAGCREIVSLQVAPLHPCQQPTRFSNRCLQMIGRCWPHLRALGVGGAGCGVQGLASLARNCMRLQVLELDHVSEITQEVAAEVCREGLKGLEMLVLTATPVTPKALLHFNSICRNLKSIVVQIGIADYFKEPSSPEAQKLFEDMVTKLQALRRRPGFSKILHIKVEGGC"},{"id":"SEQ_00489","a":"Q6W4X9","g":"MUC6","d":"Mucin-6","L":2439,"m":[{"c":"[TP]P[HF]TTHSPPT[GA][GST][ST]Pφ[SP]STGP[VM]TATSF[QHK][TA]TTTYPTPSHP[QEH]TTLPTHVP[PS]FSTSLVTPSTHTVI[TI][PT]TH[AT]QMATSAS[IN]HS[MAT]PTGT[IV]PPPTT[LI]KATGSTHTAP[PT]","u":100,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four gapless 100-aa repeats in the P/T/S-rich disordered central region sharing ~90% sequence identity across fixed aromatic, histidine, aliphatic, and basic anchors (including TTHSPPT, TATSF, TYPTPSHP, TLPTHVPxFSTSLVTPSTHTVI, QMATSASxHS, PPPTTxKATGSTHTAP), separated by 69 or 124 aa linkers.","i":[[1402,1501,"TPHTTHSPPTAGSPVPSTGPVTATSFHATTTYPTPSHPETTLPTHVPPFSTSLVTPSTHTVITPTHAQMATSASNHSAPTGTIPPPTTLKATGSTHTAPP"],[1571,1670,"PPFTTHSPPTGSSPFSSTGPMTATSFKTTTTYPTPSHPQTTLPTHVPPFSTSLVTPSTHTVITPTHAQMATSASIHSMPTGTIPPPTTLKATGSTHTAPT"],[1795,1894,"TPFTTHSPPTGTTPISSTGPVTATSFQTTTTYPTPSHPHTTLPTHVPSFSTSLVTPSTHTVIIPTHTQMATSASIHSMPTGTIPPPTTIKATGSTHTAPP"],[1964,2063,"TPFTTHSPPTGSSPFSSTGPMTATSFQTTTTYPTPSHPQTTLPTHVPPFSTSLVTPSTHTVIITTHTQMATSASIHSTPTGTVPPPTTLKATGSTHTAPP"]]},{"c":"[MI]T[PLV]TTSGTSQ[AS]xSS[FL][SN]T[AN]KT[SP]TSL[HP][SY]HTSSTHH[PA]E[VA]T[PS]TSTToITP[NK][PH]TST[GR]T[RP]","u":54,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four gapless 54-aa repeats in the disordered P/T/S-rich region (interleaved with the 100-aa repeats, including a near-tandem pair separated by 1 residue) anchored by conserved TTSGTSQ, KT[SP]TSL, HTSSTHH[PA]E[VA]T, and ITP[NK][PH]TST[GR]T motifs.","i":[[1502,1555,"ITPTTSGTSQAHSSFSTNKTPTSLHSHTSSTHHPEVTPTSTTTITPNPTSTRTR"],[1671,1724,"MTLTTSGTSQALSSLNTAKTSTSLHSHTSSTHHAEATSTSTTNITPNPTSTGTP"],[1726,1779,"MTVTTSGTSQSRSSFSTAKTSTSLHSHTSSTHHPEVTSTSTTSITPNHTSTGTR"],[1895,1948,"MTPTTSGTSQSPSSFSTAKTSTSLPYHTSSTHHPEVTPTSTTNITPKHTSTGTR"]]},{"c":"C[ST]xxG[AE][GS][HF][FV]xTFDxxxΩxFxG[TN]CxYI[FL](x){102,107}GLCGNF[DN]Gxxxx-F(x){93,98}CxxxGxxxx(x){0,1}WRxxx(x){0,1}C","u":"253-264","sp":"dispersed","x":"structured_like","cf":"high","why":"Three large ~253-264 aa structured repeats in the N-terminal half anchored by a conserved N-terminal C[ST]xxG...TFDxxxΩxFxG[TN]CxYI[FL] block, an invariant internal GLCGNF[DN]Gxxxx-F signature, multiple conserved cysteines, and a C-terminal CxxxGxxxx(x){0,1}WRxxx(x){0,1}C motif.","i":[[45,297,"CSTWGAGHFSTFDHHVYDFSGTCNYIFAATCKDAFPTFSVQLRRGPDGSISRIIVELGASVVTVSEAIISVKDIGVISLPYTSNGLQITPFGQSVRLVAKQLELELEVVWGPDSHLMVLVERKYMGQMCGLCGNFDGKVTNEFVSEEGKFLEPHKFAALQKLDDPGEICTFQDIPSTHVRQAQHARICTQLLTLVAPECSVSKEPFVLSCQADVAAAPQPGPQNSSCATLSEYSRQCSMVGQPVRRWRSPGLC"],[397,660,"CSLEGGSFVTTFDARPYRFHGTCTYILLQSPQLPEDGALMAVYDKSGVSHSETSLVAVVYLSRQDKIVISQDEVVTNNGEAKWLPYKTRNITVFRQTSTHLQMATSFGLELVVQLRPIFQAYVTVGPQFRGQTRGLCGNFNGDTTDDFTTSMGIAEGTASLFVDSWRAGNCPAALERETDPCSMSQLNKVCAETHCSMLLRTGTVFERCHATVNPAPFYKRCVYQACNYEETFPHICAALGDYVHACSLRGVLLWGWRSSVDNC"],[868,1127,"CTLYGEGHVITFDGQRFVFDGNCEYILATDVCGVNDSQPTFKILTENVICGNSGVTCSRAIKIFLGGLSVVLADRNYTVTGEEPHVQLGVTPGALSLVVDISIPGRYNLTLIWNRHMTILIRIARASQDPLCGLCGNFNGNMKDDFETRSRYVASSELELVNSWKESPLCGDVSFVTDPCSLNAFRRSWAERKCSVINSQTFATCHSKVYHLPYYEACVRDACGCDSGGDCECLCDAVAAYAQACLDKGVCVDWRTPAFC"]]},{"c":"GCxC[PA]-G[TL]φxN(x){4,7}CVxxxxCPCx[LF]xGxxΩ(x){11,12}TC[RHS]C[TIS][LNR]GRφ[VSA]C","u":"53-56","sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed 53-56 aa cysteine-rich structured repeats sharing eight conserved cysteines and fixed glycine/aromatic/hydrophobic anchors across GCxC[PA]-G[TL]φxN, CVxxxxCPCx[LF]xGxxΩ, and TCxCxxGRφxC.","i":[[333,388,"GCFCPEGTVLNDLSNNHTCVPVTQCPCVLHGAMYAPGEVTIAACQTCRCTLGRWVC"],[700,753,"GCNCPDGTYLNQKGECVRKAQCPCILEGYKFILAEQSTVINGITCHCINGRLSC"],[806,858,"GCVCAEGLYENADGQCVPPEECPCEFSGVSYPGGAELHTDCRTCSCSRGRWAC"]]}],"s":"MVQRWLLLSCCGALLSAGLANTSYTSPGLQRLKDSPQTAPDKGQCSTWGAGHFSTFDHHVYDFSGTCNYIFAATCKDAFPTFSVQLRRGPDGSISRIIVELGASVVTVSEAIISVKDIGVISLPYTSNGLQITPFGQSVRLVAKQLELELEVVWGPDSHLMVLVERKYMGQMCGLCGNFDGKVTNEFVSEEGKFLEPHKFAALQKLDDPGEICTFQDIPSTHVRQAQHARICTQLLTLVAPECSVSKEPFVLSCQADVAAAPQPGPQNSSCATLSEYSRQCSMVGQPVRRWRSPGLCSVGQCPANQVYQECGSACVKTCSNPQHSCSSSCTFGCFCPEGTVLNDLSNNHTCVPVTQCPCVLHGAMYAPGEVTIAACQTCRCTLGRWVCTERPCPGHCSLEGGSFVTTFDARPYRFHGTCTYILLQSPQLPEDGALMAVYDKSGVSHSETSLVAVVYLSRQDKIVISQDEVVTNNGEAKWLPYKTRNITVFRQTSTHLQMATSFGLELVVQLRPIFQAYVTVGPQFRGQTRGLCGNFNGDTTDDFTTSMGIAEGTASLFVDSWRAGNCPAALERETDPCSMSQLNKVCAETHCSMLLRTGTVFERCHATVNPAPFYKRCVYQACNYEETFPHICAALGDYVHACSLRGVLLWGWRSSVDNCTIPCTGNTTFSYNSQACERTCLSLSDRATECHHSAVPVDGCNCPDGTYLNQKGECVRKAQCPCILEGYKFILAEQSTVINGITCHCINGRLSCPQRPQMFLASCQAPKTFKSCSQSSENKFGAACAPTCQMLATGVACVPTKCEPGCVCAEGLYENADGQCVPPEECPCEFSGVSYPGGAELHTDCRTCSCSRGRWACQQGTHCPSTCTLYGEGHVITFDGQRFVFDGNCEYILATDVCGVNDSQPTFKILTENVICGNSGVTCSRAIKIFLGGLSVVLADRNYTVTGEEPHVQLGVTPGALSLVVDISIPGRYNLTLIWNRHMTILIRIARASQDPLCGLCGNFNGNMKDDFETRSRYVASSELELVNSWKESPLCGDVSFVTDPCSLNAFRRSWAERKCSVINSQTFATCHSKVYHLPYYEACVRDACGCDSGGDCECLCDAVAAYAQACLDKGVCVDWRTPAFCPIYCGFYNTHTQDGHGEYQYTQEANCTWHYQPCLCPSQPQSVPGSNIEGCYNCSQDEYFDHEEGVCVPCMPPTTPQPPTTPQLPTTGSRPTQVWPMTGTSTTIGLLSSTGPSPSSNHTPASPTQTPLLPATLTSSKPTASSGEPPRPTTAVTPQATSGLPPTATLRSTATKPTVTQATTRATASTASPATTSTAQSTTRTTMTLPTPATSGTSPTLPKSTNQELPGTTATQTTGPRPTPASTTGPTTPQPGQPTRPTATETTQTRTTTEYTTPQTPHTTHSPPTAGSPVPSTGPVTATSFHATTTYPTPSHPETTLPTHVPPFSTSLVTPSTHTVITPTHAQMATSASNHSAPTGTIPPPTTLKATGSTHTAPPITPTTSGTSQAHSSFSTNKTPTSLHSHTSSTHHPEVTPTSTTTITPNPTSTRTRTPVAHTNSATSSRPPPPFTTHSPPTGSSPFSSTGPMTATSFKTTTTYPTPSHPQTTLPTHVPPFSTSLVTPSTHTVITPTHAQMATSASIHSMPTGTIPPPTTLKATGSTHTAPTMTLTTSGTSQALSSLNTAKTSTSLHSHTSSTHHAEATSTSTTNITPNPTSTGTPPMTVTTSGTSQSRSSFSTAKTSTSLHSHTSSTHHPEVTSTSTTSITPNHTSTGTRTPVAHTTSATSSRLPTPFTTHSPPTGTTPISSTGPVTATSFQTTTTYPTPSHPHTTLPTHVPSFSTSLVTPSTHTVIIPTHTQMATSASIHSMPTGTIPPPTTIKATGSTHTAPPMTPTTSGTSQSPSSFSTAKTSTSLPYHTSSTHHPEVTPTSTTNITPKHTSTGTRTPVAHTTSASSSRLPTPFTTHSPPTGSSPFSSTGPMTATSFQTTTTYPTPSHPQTTLPTHVPPFSTSLVTPSTHTVIITTHTQMATSASIHSTPTGTVPPPTTLKATGSTHTAPPMTVTTSGTSQTHSSFSTATASSSFISSSSWLPQNSSSRPPSSPITTQLPHLSSATTPVSTTNQLSSSFSPSPSAPSTVSSYVPSSHSSPQTSSPSVGTSSSFVSAPVHSTTLSSGSHSSLSTHPTTASVSASPLFPSSPAASTTIRATLPHTISSPFTLSALLPISTVTVSPTPSSHLASSTIAFPSTPRTTASTHTAPAFSSQSTTSRSTSLTTRVPTSGFVSLTSGVTGIPTSPVTNLTTRHPGPTLSPTTRFLTSSLTAHGSTPASAPVSSLGTPTPTSPGVCSVREQQEEITFKGCMANVTVTRCEGACISAASFNIITQQVDARCSCCRPLHSYEQQLELPCPDPSTPGRRLVLTLQVFSHCVCSSVACGD"},{"id":"SEQ_00493","a":"P38159","g":"RBMX","d":"RNA-binding motif protein, X chromosome","L":391,"m":[{"c":"DxY[SG][SG][SGR]","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Six copies in the C-terminal RS/SY-rich disordered region share invariant D1 and Y3 anchors followed by a [SG][SG][SGR] tract (including a tight 4-copy cluster at residues 311-338 plus dispersed copies), typically flanked by basic R/K residues ([RK]DxY[SG]{2,4}R).","i":[[218,223,"DSYSSR"],[311,316,"DDYSSS"],[318,323,"DGYGGS"],[325,330,"DSYSSS"],[333,338,"DLYSSG"],[362,367,"DSYSSS"]]},{"c":"[RG]GPP[PRS]+","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Four non-overlapping copies in the central proline/glycine-rich disordered segment conserve a fixed GPP core flanked by an N-terminal [RG] and a C-terminal basic (+) residue.","i":[[120,125,"RGPPSR"],[151,156,"RGPPPR"],[158,163,"GGPPPK"],[191,196,"GGPPRR"]]}],"s":"MVEADRPGKLFIGGLNTETNEKALEAVFGKYGRIVEVLLMKDRETNKSRGFAFVTFESPADAKDAARDMNGKSLDGKAIKVEQATKPSFESGRRGPPPPPRSRGPPRGLRGGRGGSGGTRGPPSRGGHMDDGGYSMNFNMSSSRGPLPVKRGPPPRSGGPPPKRSAPSGPVRSSSGMGGRAPVSRGRDSYGGPPRREPLPSRRDVYLSPRDDGYSTKDSYSSRDYPSSRDTRDYAPPPRDYTYRDYGHSSSRDDYPSRGYSDRDGYGRDRDYSDHPSGGSYRDSYESYGNSRSAPPTRGPPPSYGGSSRYDDYSSSRDGYGGSRDSYSSSRSDLYSSGRDRVGRQERGLPPSMERGYPPPRDSYSSSSRGAPRGGGRGGSRSDRGGGRSRY"},{"id":"SEQ_00512","a":"Q9UPX0","g":"IGSF9B","d":"Protein turtle homolog B","L":1349,"m":[{"c":"(x){2,9}P(x){11,13}ψxC(x){9,14}φxW(x){16,27}[GA][ST]ψxφxxφxxE[DA]xGxΩ[TE]C(x){13,18}[HYR]L[LT]ψx","u":"89-109","sp":"tandem","x":"structured_like","cf":"high","why":"Five head-to-tail tandem ~90-109 aa structured repeats in the N-terminal half anchored by invariant paired cysteines, an internal φxW motif, a highly conserved 18-residue [GA][ST]ψxφxxφxxE[DA]xGxΩ[TE]C block, and a C-terminal [HYR]L[LT]ψx motif.","i":[[28,136,"EEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTIN"],[137,226,"APPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQ"],[227,322,"GPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQ"],[323,417,"YPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLK"],[418,506,"DPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVI"]]},{"c":"xxxxxPxxψxψxx(x){6,15}φSWxP(x){38,39}[TD]Lxx-TφY[QE]F[SR]VLAxxxxxxSxxSxxφ[TG]Voo","u":"94-102","sp":"tandem","x":"structured_like","cf":"high","why":"Two tandem ~94-102 aa structured repeats separated by a 2-residue linker immediately C-terminal to the first repeat array, sharing an N-terminal Pxxψxψ motif, a conserved φSWxP turn, and a strongly conserved 31-residue C-terminal [TD]Lxx-TφY[QE]F[SR]VLA...SxxS...[TG]Voo segment.","i":[[508,601,"TSPHAPGSVRVQVSMTTANVSWEPGYDGGYEQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVNT"],[604,705,"FPITTPEPLVLVTPPRCLIANRTQQGVLLSWLPPANHSFPIDRYIMEFRVAERWELLDDGIPGTEGEFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSS"]]}],"s":"MIWYVATFIASVIGTRGLAAEGAHGLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGYEQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVNTLAFPITTPEPLVLVTPPRCLIANRTQQGVLLSWLPPANHSFPIDRYIMEFRVAERWELLDDGIPGTEGEFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSSTDIFPQPDLTEDGLARPVLAGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKKDPPLSITHCRKSLESPLSSGKVSPESIRTLRAPSESSDDQGQPAAKRMLSPTREKELSLYKKTKRAISSKKYSVAKAEAEAEATTPIELISRGPDGRFVMDPAEMEPSLKSRRIEGFPFAEETDMYPEFRQSDEENEDPLVPTSVAALKSQLTPLSSSQESYLPPPAYSPRFQPRGLEGPGGLEGRLQATGQARPPAPRPFHHGQYYGYLSSSSPGEVEPPPFYVPEVGSPLSSVMSSPPLPTEGPFGHPTIPEENGENASNSTLPLTQTPTGGRSPEPWGRPEFPFGGLETPAMMFPHQLPPCDVPESLQPKAGLPRGLPPTSLQVPAAYPGILSLEAPKGWAGKSPGRGPVPAPPAAKWQDRPMQPLVSQGQLRHTSQGMGIPVLPYPEPAEPGAHGGPSTFGLDTRWYEPQPRPRPSPRQARRAEPSLHQVVLQPSRLSPLTQSPLSSRTGSPELAARARPRPGLLQQAEMSEITLQPPAAVSFSRKSTPSTGSPSQSSRSGSPSYRPAMGFTTLATGYPSPPPGPAPAGPGDSLDVFGQTPSPRRTGEELLRPETPPPTLPTSGKLQRDRPAPATSPPERALSKL"},{"id":"SEQ_00516","a":"Q6P3S6","g":"FBXO42","d":"F-box only protein 42","L":717,"m":[{"c":"P(x){3,6}[GHS]xxxx[VY](x){4,5}ψφψ[FL]GG(x){17,27}Ωφxxxx","u":"44-54","sp":"dispersed","x":"structured_like","cf":"high","why":"Five ~44-54 aa structured repeats (four closely spaced copies in the N-terminal half and a fifth C-terminal copy separated by a long central disordered insertion) defined by an N-terminal P anchor, a [GHS]xxxx[VY] segment, a hallmark ψφψ[FL]GG hydrophobic-diglycine core, and a C-terminal Ωφ aromatic-hydrophobic pair.","i":[[115,166,"PITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLA"],[171,224,"PSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIV"],[229,273,"PPPMAGHSSCVIDDKMIVFGGSLGSRQMSNDVWVLDLEQWAWSKP"],[280,327,"PHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPL"],[673,716,"PPETSLHTVVQGRGELIIFGGLMDKKQNVKYYPKTNALYFVRAK"]]}],"s":"MASSSDSEDDSFMAVDQEETVLEGTMDQDEEPHPVLEAEETRHNRSMSELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKGVAHQCYHGFMKAVQEGNIQWESRTYPYPGTPITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVIDDKMIVFGGSLGSRQMSNDVWVLDLEQWAWSKPNISGPSPHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVENEEHGAPELWCHPACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTPSGSREGSLSPARGDGSPILNGGSLSPGTAAVGGSSLDSPVQAISPSTPSAPEGYDLKIGLSLAPRRGSLPDQKDLRLGSIDLNWDLKPASSSNPMDGMDNRTVGGSMRHPPEQTNGVHTPPHVASALAGAVSPGALRRSLEAIKAMSSKGPSASAALSPPLGSSPGSPGSQSLSSGETVPIPRPGPAQGDGHSLPPIARRLGHHPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFNSSSVVGPPETSLHTVVQGRGELIIFGGLMDKKQNVKYYPKTNALYFVRAKR"},{"id":"SEQ_00526","a":"O15061","g":"SYNM","d":"Synemin","L":1565,"m":[{"c":"[GD]x[SQ][RTQ][STA]φR[HQ]ψx[LIP]GPx[EQR](x){2,4}xxφxφx[GAV][PLS]","u":"25-27","sp":"dispersed","x":"structured_like","cf":"high","why":"Six C-terminal copies of a 25-27 aa repeat module anchored by an invariant R...GP core ([GD]x[SQ][RTQ][STA]φR[HQ]ψx[LIP]GP) followed after a 4-6 aa turn by a conserved hydrophobic dyad and second GP-like turn (φxφx[GAV][PLS]). Copies occur in three pairs separated alternately by 20 aa and 64-66 aa linkers.","i":[[1119,1145,"DVSQAARHIKLGPSEVWRTERMSYEGP"],[1166,1192,"GASRSVRHVTLGPGQSPLSREVIFLGP"],[1257,1282,"GTQTSVRQLQLGPKEGFSGQIQFTAP"],[1303,1329,"GSSTSIRHISIGPQRHQTTQQIVYHGL"],[1396,1422,"GVSRSFRHIRLGPTETETSEHIAIRGP"],[1443,1467,"DSSRTLRHIAPGPKETSFTFQMDVS"]]}],"s":"MLSWRLQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLRARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEVATYRALLEGESNPEIVIWAEHVENMPSEFRNKSYHYTDSLLQRENERNLFSRQKAPLASFNHSSALYSNLSGHRGSQTGTSIGGDARRGFLGSGYSSSATTQQENSYGKAVSSQTNVRTFSPTYGLLRNTEAQVKTFPDRPKAGDTREVPVYIGEDSTIARESYRDRRDKVAAGASESTRSNERTVILGKKTEVKATREQERNRPETIRTKPEEKMFDSKEKASEERNLRWEELTKLDKEARQRESQQMKEKAKEKDSPKEKSVREREVPISLEVSQDRRAEVSPKGLQTPVKDAGGGTGREAEARELRFRLGTSDATGSLQGDSMTETVAENIVTSILKQFTQSPETEASADSFPDTKVTYVDRKELPGERKTKTEIVVESKLTEDVDVSDEAGLDYLLSKDIKEVGLKGKSAEQMIGDIINLGLKGREGRAKVVNVEIVEEPVSYVSGEKPEEFSVPFKVEEVEDVSPGPWGLVKEEEGYGESDVTFSVNQHRRTKQPQENTTHVEEVTEAGDSEGEQSYFVSTPDEHPGGHDRDDGSVYGQIHIEEESTIRYSWQDEIVQGTRRRTQKDGAVGEKVVKPLDVPAPSLEGDLGSTHWKEQARSGEFHAEPTVIEKEIKIPHEFHTSMKGISSKEPRQQLVEVIGQLEETLPERMREELSALTREGQGGPGSVSVDVKKVQGAGGSSVTLVAEVNVSQTVDADRLDLEELSKDEASEMEKAVESVVRESLSRQRSPAPGSPDEEGGAEAPAAGIRFRRWATRELYIPSGESEVAGGASHSSGQRTPQGPVSATVEVSSPTGFAQSQVLEDVSQAARHIKLGPSEVWRTERMSYEGPTAEVVEVSAGGDLSQAASPTGASRSVRHVTLGPGQSPLSREVIFLGPAPACPEAWGSPEPGPAESSADMDGSGRHSTFGCRQFHAEKEIIFQGPISAAGKVGDYFATEESVGTQTSVRQLQLGPKEGFSGQIQFTAPLSDKVELGVIGDSVHMEGLPGSSTSIRHISIGPQRHQTTQQIVYHGLVPQLGESGDSESTVHGEGSADVHQATHSHTSGRQTVMTEKSTFQSVVSESPQEDSAEDTSGAEMTSGVSRSFRHIRLGPTETETSEHIAIRGPVSRTFVLAGSADSPELGKLADSSRTLRHIAPGPKETSFTFQMDVSNVEAIRSRTQEAGALGVSDRGSWRDADSRNDQAVGVSFKASAGEGDQAHREQGKEQAMFDKKVQLQRMVDQRSVISDEKKVALLYLDNEEEENDGHWF"},{"id":"SEQ_00545","a":"Q9NW13","g":"RBM28","d":"RNA-binding protein 28","L":759,"m":[{"c":"ψ[FI][VI](x){1,8}[RN]L[PS]xxxxxxxLxx[LV][FL](x){8,14}[CV]x[VI]x(x){8,15}G[FCY][GA][YF][VA]xFxxxxxxx+[AC]L(x){10,20}[IV][NDE]φ[TAS][VL]","u":"72-98","sp":"dispersed","x":"structured_like","cf":"high","why":"Four dispersed 72-98 aa structured repeats separated by variable charged/polar linkers, anchored by an N-terminal ψ[FI][VI]...(x){1,8}[RN]L[PS] hydrophobic-turn motif, conserved leucine-bearing amphipathic segments, a signature G[FCY][GA][YF][VA]xF glycine-aromatic core, and a C-terminal [IV][NDE]φ[TAS][VL] hydrophobic segment.","i":[[6,77,"LFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKEITTFEGCKINVTV"],[116,190,"LIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTVAVDWAV"],[337,418,"VFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGRQLKVDLAV"],[482,579,"IFVSRTRLCLHNLPKAVDDKQLRKLLLSATSGEKGVRIKECRVMRDLKGVHGNMKGQSLGYAFAEFQEHEHALKALRLINNNPEIFGPLKRPIVEFSL"]]}],"s":"MAGLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQRALKEITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIKGRTVAVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDMEEEENDDDDDDDDEEDGVFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAKSSDHSEEDSDLEESDSIDDGEELAQSDTSTEEQEDKAVQVSNKKKRKLPSDVNEGKTVFIRNLSFDSEEEELGELLQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGRQLKVDLAVTRDEAAKLQTTKVKKPTGTRNLYLAREGLIRAGTKAAEGVSAADMAKRERFELLKHQKLKDQNIFVSRTRLCLHNLPKAVDDKQLRKLLLSATSGEKGVRIKECRVMRDLKGVHGNMKGQSLGYAFAEFQEHEHALKALRLINNNPEIFGPLKRPIVEFSLEDRRKLKMKELRIQRSLQKMRSKPATGEPQKGQPEPAKDQQQKAAQHHTEEQSKVPPEQKRKAGSTSWTGFQTKAEVEQVELPDGKKRRKVLALPSHRGPKIRLRDKGKVKPVHPKKPKPQINQWKQEKQQLSSEQVSRKKAKGNKTETRFNQLVEQYKQKLLGPSKGAPLAKRSKWFDS"},{"id":"SEQ_00566","a":"A0A1B0GV03","g":"GOLGA6L7","d":"Golgin subfamily A member 6-like protein 7","L":622,"m":[{"c":"Q[EK][EK]Q[MI]x[KE]","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"30-copy tandem 7-residue array anchored by invariant Q at positions 1 and 4, conserved aliphatic M/I at position 5, E/K at positions 2-3, and K/E at position 7 (interrupted once by a 4-residue partial unit QMRK).","i":[[281,287,"QEEQMRK"],[288,294,"QEEQMRK"],[295,301,"QEEQMRK"],[302,308,"QEEQMRK"],[309,315,"QEEQMRK"],[316,322,"QEEQMRK"],[323,329,"QEEQMGK"],[330,336,"QEEQMGE"],[337,343,"QEEQMRK"],[344,350,"QEKQMLK"],[351,357,"QKEQMRK"],[358,364,"QEEQMWK"],[365,371,"QEEQIGE"],[372,378,"QEEQMRK"],[379,385,"QEEQMWK"],[386,392,"QEEQIGE"],[393,399,"QEEQMRK"],[400,406,"QEEQMWK"],[407,413,"QEEQMGE"],[418,424,"QEEQMGE"],[425,431,"QEEQIRK"],[432,438,"QEEQMGE"],[439,445,"QEEQMRK"],[446,452,"QEEQMGE"],[453,459,"QEEQMRK"],[460,466,"QEEQMGE"],[467,473,"QEEQMRK"],[474,480,"QEEQMGE"],[481,487,"QEEQMGE"],[488,494,"QEEQMRK"]]}],"s":"MMSEKTQQRKLAGTKKKFTDYHQWNSAGVGTGATDTKKKKINHGANPETTTSGGCHSPEDKQQNRAQLKEENKASHQHQQALRRQLEAQDHTIRILMCQKTELETALHDSQDAARKFEEDSKDLAARLHHSWHFAGELQRALSAMSAEHERADKYIKELTKEREAMSLELFRNIITNKELKEKNAELQEKLRLVETEKSEIQLHIKELKRKLETDKIPLPQVQTNTLQEKMWRQEEELRDQEELRDQEKLRKHEEKMWRQEQRLRDQEKELREQEQQMQEQEEQMRKQEEQMRKQEEQMRKQEEQMRKQEEQMRKQEEQMRKQEEQMGKQEEQMGEQEEQMRKQEKQMLKQKEQMRKQEEQMWKQEEQIGEQEEQMRKQEEQMWKQEEQIGEQEEQMRKQEEQMWKQEEQMGEQMRKQEEQMGEQEEQIRKQEEQMGEQEEQMRKQEEQMGEQEEQMRKQEEQMGEQEEQMRKQEEQMGEQEEQMGEQEEQMRKQVERLQFKEERLWDEYEKMQEEEEKIRRQVEKRREKKERMGEQEKTQEERCSEPCLPPSKYPSDMSHPGSLEPAREAGKGYSHDNRTAQIMQLPPGMKNAQERPGLGSTSCIPFFYGGDKKKIKIISI"},{"id":"SEQ_00576","a":"P04279","g":"SEMG1","d":"Semenogelin-1","L":462,"m":[{"c":"x[KS][AG][NK][KG]IS[YS]Q[SY]S[SN]TEER[RL][LW][HV][YH]G[EL][NS][GK][VE]Q[KT][DS]VS(x){0,11}Q[SR]S[IY][YV][SL]QTE[EK][LK][VA][AQ][GN]K[SQ]Qx[QE]xx[NI][PS]xQ[EN]xxHx","u":"60-71","sp":"dispersed","x":"disordered_like","cf":"high","why":"60-71 aa polar-rich repeat occurring 3 times (one upstream copy with an 11-aa internal linker separated by a divergent 60-aa segment from two 75%-identical head-to-tail 60-aa tandem copies), anchored by 21 invariant positions including paired ISxQxSxTEER...G...QxxVS and QxSφφxQTExxxK...Q...H submotifs.","i":[[150,220,"PSGKGISSQYSNTEERLWVHGLSKEQTSVSGAQKGRKQGGSQSSYVLQTEELVANKQQRETKNSHQNKGHY"],[281,340,"RKANKISYQSSSTEERRLHYGENGVQKDVSQSSIYSQTEEKAQGKSQKQITIPSQEQEHS"],[341,400,"QKANKISYQSSSTEERRLHYGENGVQKDVSQRSIYSQTEKLVAGKSQIQAPNPKQEPWHG"]]}],"s":"MKPNIIFVLSLLLILEKQAAVMGQKGGSKGRLPSEFSQFPHGQKGQHYSGQKGKQQTESKGSFSIQYTYHVDANDHDQSRKSQQYDLNALHKTTKSQRHLGGSQQLLHNKQEGRDHDKSKGHFHRVVIHHKGGKAHRGTQNPSQDQGNSPSGKGISSQYSNTEERLWVHGLSKEQTSVSGAQKGRKQGGSQSSYVLQTEELVANKQQRETKNSHQNKGHYQNVVEVREEHSSKVQTSLCPAHQDKLQHGSKDIFSTQDELLVYNKNQHQTKNLNQDQQHGRKANKISYQSSSTEERRLHYGENGVQKDVSQSSIYSQTEEKAQGKSQKQITIPSQEQEHSQKANKISYQSSSTEERRLHYGENGVQKDVSQRSIYSQTEKLVAGKSQIQAPNPKQEPWHGENAKGESGQSTNREQDLLSHEQKGRHQHGSHGGLDIVIIEQEDDSDRHLAQHLNNDRNPLFT"},{"id":"SEQ_00581","a":"Q7Z7K2","g":"ZNF467","d":"Zinc finger protein 467","L":595,"m":[{"c":"x[GP]x[KRG][PS]xxCxxCxxxFxxxxxφxxHxxxH","u":28,"sp":"tandem","x":"structured_like","cf":"high","why":"Twelve 28-residue repeats defined by invariant CxxC, F, hydrophobic (φ), and HxxxH anchors preceded by a conserved x[GP]x[KRG][PS] linker, organized into two head-to-tail tandem arrays (6 and 5 copies) plus one central linker-separated copy.","i":[[155,182,"MPEKPYGCGECERRFRDQLTLRLHQRLH"],[183,210,"RGEGPCACPDCGRSFTQRAHMLLHQRSH"],[211,238,"RGERPFPCSECDKRFSKKAHLTRHLRTH"],[239,266,"TGERPYPCAECGKRFSQKIHLGSHQKTH"],[267,294,"TGERPFPCTECEKRFRKKTHLIRHQRIH"],[295,322,"TGERPYQCAQCARSFTHKQHLVRHQRVH"],[350,377,"PGPKPFACSDCGLSFGWKKNLATHQCLH"],[426,453,"SGERSFFCPDCGRGFSHGQHLARHPRVH"],[454,481,"TGERPFACTQCDRRFGSRPNLVAHSRAH"],[482,509,"SGARPFACAQCGRRFSRKSHLGRHQAVH"],[510,537,"TGSRPHACAVCARSFSSKTNLVRHQAIH"],[538,565,"TGSRPFSCPQCGKSFSRKTHLVRHQLIH"]]}],"s":"MRETLEALSSLGFSVGQPEMAPQSEPREGSHNAQEQMSSSREERALGVCSGHEAPTPEEGAHTEQAEAPCRGQACSAQKAQPVGTCPGEEWMIRKVKVEDEDQEAEEEVEWPQHLSLLPSPFPAPDLGHLAAAYKLEPGAPGALSGLALSGWGPMPEKPYGCGECERRFRDQLTLRLHQRLHRGEGPCACPDCGRSFTQRAHMLLHQRSHRGERPFPCSECDKRFSKKAHLTRHLRTHTGERPYPCAECGKRFSQKIHLGSHQKTHTGERPFPCTECEKRFRKKTHLIRHQRIHTGERPYQCAQCARSFTHKQHLVRHQRVHQTAGPARPSPDSSASPHSTAPSPTPSFPGPKPFACSDCGLSFGWKKNLATHQCLHRSEGRPFGCDECALGATVDAPAAKPLASAPGGPGCGPGSDPVVPQRAPSGERSFFCPDCGRGFSHGQHLARHPRVHTGERPFACTQCDRRFGSRPNLVAHSRAHSGARPFACAQCGRRFSRKSHLGRHQAVHTGSRPHACAVCARSFSSKTNLVRHQAIHTGSRPFSCPQCGKSFSRKTHLVRHQLIHGEAAHAAPDAALAAPAWSAPPEVAPPPLFF"},{"id":"SEQ_00583","a":"Q9Y2P0","g":"ZNF835","d":"Zinc finger protein 835","L":537,"m":[{"c":"[TG][GPE][EK]+PxxCxxC[GA][KA][ALR]Fxxxxx[LF]xxHxx[ITV]H","u":28,"sp":"tandem","x":"structured_like","cf":"high","why":"Fourteen contiguous head-to-tail 28-residue tandem repeats anchored by invariant P, CxxC, F, and Hxx[ITV]H positions along with a conserved N-terminal [TG][GPE][EK]+ linker and hydrophobic [LF] core residue.","i":[[105,132,"GPKKPWKCGDCGKAFSYCSAFILHQRIH"],[133,160,"TGEKPFACPECGKAFSQSVHLTLHQRTH"],[161,188,"TGEKPYACHECGKAFSQGSYLASHWRTH"],[189,216,"TGEKPHRCADCGKAFTRVTHLTQHRRVH"],[217,244,"TGERPYACAQCAKAFRNRSSLIEHQRIH"],[245,272,"TGEKPYECSACAKAFRFSSALIRHQRIH"],[273,300,"TEEKPYRCGQCAKAFAQIAHLTQHRRVH"],[301,328,"TGEKPYTCQDCGALFSQSASLAEHRRIH"],[329,356,"TGEKPYACGQCAKAFTQVSHLTQHQRTH"],[357,384,"TGERPYPCHDCGKRFSNRSHLLQHRLVH"],[385,412,"TGERPYRCLQCGAAFSHVSSLIEHQKIH"],[413,440,"TGERPYKCGECGKAFSQGSSLALHQRTH"],[441,468,"TGERPYTCPECGKAFSNRSYLIQHHIVH"],[469,496,"TGEKPYECSGCGKAFSFSSALIRHQRTH"]]}],"s":"MEGLLSVALQGAELEGNWKHEGQVEDLQENQESCPEPEAVACKGDPAGDSMQERDEFSRIPRTISSPAATQASVPDDSSSRRCSAPGESPKERHPDSRQRERGGGPKKPWKCGDCGKAFSYCSAFILHQRIHTGEKPFACPECGKAFSQSVHLTLHQRTHTGEKPYACHECGKAFSQGSYLASHWRTHTGEKPHRCADCGKAFTRVTHLTQHRRVHTGERPYACAQCAKAFRNRSSLIEHQRIHTGEKPYECSACAKAFRFSSALIRHQRIHTEEKPYRCGQCAKAFAQIAHLTQHRRVHTGEKPYTCQDCGALFSQSASLAEHRRIHTGEKPYACGQCAKAFTQVSHLTQHQRTHTGERPYPCHDCGKRFSNRSHLLQHRLVHTGERPYRCLQCGAAFSHVSSLIEHQKIHTGERPYKCGECGKAFSQGSSLALHQRTHTGERPYTCPECGKAFSNRSYLIQHHIVHTGEKPYECSGCGKAFSFSSALIRHQRTHADSSGRLCPAPTPDSTPGLSQGGETCQQGCPGRNPRGPAED"},{"id":"SEQ_00594","a":"P42696","g":"RBM34","d":"RNA-binding protein 34","L":430,"m":[{"c":"R[TS]VFVGNLPφxxxxxxψxxxFx-xGoIxxVRφ(x){13,30}YVψFxxxxxφxxALK(x){9,10}+ψRV","u":"73-91","sp":"dispersed","x":"structured_like","cf":"high","why":"Two-copy internal duplication of a 73-91 residue structured module separated by an 11-residue linker, sharing strongly conserved R[TS]VFVGNLP, Fx-xGoIxxVRφ, YVψFxxxxxφxxALK, and +ψRV blocks across two variable-length internal loops.","i":[[185,275,"RTVFVGNLPVTCNKKKLKSFFKEYGQIESVRFRSLIPAEGTLSKKLAAIKRKIHPDQKNINAYVVFKEESAATQALKRNGAQIADGFRIRV"],[287,359,"RSVFVGNLPYKVEESAIEKHFLDCGSIMAVRIVRDKMTGIGKGFGYVLFENTDSVHLALKLNNSELMGRKLRV"]]}],"s":"MALEGMSKRKRKRSVQEGENPDDGVRGSPPEDYRLGQVASSLFRGEHHSRGGTGRLASLFSSLEPQIQPVYVPVPKQTIKKTKRNEEEESTSQIERPLSQEPAKKVKAKKKHTNAEKKLADRESALASADLEEEIHQKQGQKRKNSQPGVKVADRKILDDTEDTVVSQRKKIQINQEEERLKNERTVFVGNLPVTCNKKKLKSFFKEYGQIESVRFRSLIPAEGTLSKKLAAIKRKIHPDQKNINAYVVFKEESAATQALKRNGAQIADGFRIRVDLASETSSRDKRSVFVGNLPYKVEESAIEKHFLDCGSIMAVRIVRDKMTGIGKGFGYVLFENTDSVHLALKLNNSELMGRKLRVMRSVNKEKFKQQNSNPRLKNVSKPKQGLNFTSKTAEGHPKSLFIGEKAVLLKTKKKGQKKSGRPKKQRKQK"},{"id":"SEQ_00607","a":"Q13099","g":"IFT88","d":"Intraflagellar transport protein 88 homolog","L":824,"m":[{"c":"xx[GAS]xx[YFV]xxxxxxxxAxxxφxxxxxxxxxxxxxxx","u":34,"sp":"tandem","x":"structured_like","cf":"high","why":"34-residue structured helical repeat defined by small [GAS] at position 3, hydrophobic/aromatic [YFV] at position 6, an invariant A anchor at position 15, hydrophobic φ at position 19, and frequent P at position 27, forming a 7-copy head-to-tail tandem array (residues 455-692) plus an N-terminal pair (residues 238-310).","i":[[238,271,"NMGNIYLKQRNYSKAIKFYRMALDQVPSVNKQMR"],[277,310,"NIGVTFIQAGQYSDAINSYEHIMSMAPNLKAGYN"],[455,488,"NLSALYYMGKDFAQASSYADIAVNSDRYNPAALT"],[489,522,"NKGNTVFANGDYEKAAEFYKEALRNDSSCTEALY"],[523,556,"NIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLY"],[557,590,"QIANIYELMENPSQAIEWLMQVVSVIPTDPQVLS"],[591,624,"KLGELYDREGDKSQAFQYYYESYRYFPCNIEVIE"],[625,658,"WLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQL"],[659,692,"MVASCFRRSGNYQKALDTYKDTHRKFPENVECLR"]]},{"c":"[VI][TG]RP[IM][AT]","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three closely spaced copies in the N-terminal S/T/G/P-rich disordered tail (residues 61-96) anchored by an invariant RP dipeptide flanked by aliphatic [VI]/[IM] and small polar [TG]/[AT] positions.","i":[[61,66,"VTRPIA"],[79,84,"IGRPMT"],[91,96,"VTRPMT"]]}],"s":"MMQNVHLAPETDEDDLYSGYNDYNPIYDIEELENDAAFQQAVRTSHGRRPPITAKISSTAVTRPIATGYGSKTSLASSIGRPMTGAIQDGVTRPMTAVRAAGFTKAALRGSAFDPLSQSRGPASPLEAKKKDSPEEKIKQLEKEVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVRQREQVTTPENINLDLTYSVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEINKAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEKMKEIREQRIKSGRDGSGGSRGKREGSASGDSGQNYSASSKGERLSARLRALPGTNEPYESSSNKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE"},{"id":"SEQ_00612","a":"Q13554","g":"CAMK2B","d":"Calcium/calmodulin-dependent protein kinase type II subunit beta","L":666,"m":[{"c":"PR[VI][PS]DIL[SN]SVRRGSG[AT]PEAEGP[LS](x){0,5}PC[PL]SP[AT]xx[SG]PL[PS]xPS","u":"38-43","sp":"tandem","x":"disordered_like","cf":"high","why":"Three contiguous head-to-tail tandem copies in the central P/S/G-rich disordered linker (residues 410-533) sharing a highly conserved N-terminal PRxxDILxSVRRGSGxPEAEGPx segment and a C-terminal PCxSPxxxxPLxxPS proline/cysteine-anchored segment separated by a 5-residue insertion in copies 2 and 3.","i":[[410,447,"PRVPDILSSVRRGSGAPEAEGPLPCPSPAPFSPLPAPS"],[448,490,"PRISDILNSVRRGSGTPEAEGPLSAGPPPCLSPALLGPLSSPS"],[491,533,"PRISDILNSVRRGSGTPEAEGPSPVGPPPCPSPTIPGPLPTPS"]]}],"s":"MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALEPQTTVIHNPVDGIKESSDSANTTIEDEDAKAPRVPDILSSVRRGSGAPEAEGPLPCPSPAPFSPLPAPSPRISDILNSVRRGSGTPEAEGPLSAGPPPCLSPALLGPLSSPSPRISDILNSVRRGSGTPEAEGPSPVGPPPCPSPTIPGPLPTPSRKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPVAPLQ"},{"id":"SEQ_00630","a":"Q8IYW2","g":"CFAP46","d":"Cilia- and flagella-associated protein 46","L":2715,"m":[{"c":"YGLAQGA[VM]AEEEGRLHS[IV]QGL","u":21,"sp":"tandem","x":"structured_like","cf":"high","why":"Head-to-tail 21-residue internal duplication (residues 1812-1853) within a structured helical region conserving 19 of 21 identical positions (including Y, G, L, Q, EEEGRLHS, and QGL anchors) and conservative large aliphatic substitutions ([VM] and [IV]) at the remaining two sites.","i":[[1812,1832,"YGLAQGAVAEEEGRLHSIQGL"],[1833,1853,"YGLAQGAMAEEEGRLHSVQGL"]]},{"c":"KEKE[NK]ERS","u":8,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Three contiguous 8-residue tandem copies (residues 1368-1391) in a highly charged disordered linker, anchored beyond simple KE alternation by a fixed C-terminal RS dipeptide across all three copies and N at position 5 in two copies.","i":[[1363,1370,"KEKENERS"],[1371,1378,"KEKEKERS"],[1379,1386,"KEKENERS"]]}],"s":"MDLVITQELARAESQQDAASLKKAYELIKSANLGKSEFDPSESFSPDLFVLCAEQALKMRQPEVSEDCIQMYFKVKAPITQFLGRAHLCRAQMCAPKSAENLEEFENCVTEYMKAINFAKGEPRYYFLVYNASVLYWQMVRPFLKPGYRHHLIPSLSQIINVLSQTEEEDKEWRAELMLELLECYLQAGRKEEAARFCSTAAPFIKSHVPQKYRQIFSVMVRHELMDELQLKEEKKNSISLSVTFYINMLKAKAEQNDLPGDISVILRKAYRHLGHYNHQRFPSISEEKMLLLFELARFSLTLKCMEISSACLSDLKKMESKDPGKLIEMECLECESEALRLESKMKVYNRAAVEAQLDIIQRLDVALQRAVRLGDPRVIHVVCATQWNTCLPLLQHNLRHHLRKPLAGVADVLEKLDSLMTLLRCQVHMEMAQIEEDEDRLEPATEHLRKAARLDSLGLYRDRIQMASTRLRLCTTLYQAPERAEDKAIMAVEQAKKATPKDSVRKKRALLVNAGLALAPDAFQIVLDSENEAKVSTGKNRGRFTYLCAKAWHHTVSVDKAAGHLRRLGNENDKERIQIWAELAKVARKQGVWDVCRTASRFCLLYDNVKVKKLRLRRGKKKRGRDGSVQDTWSQPEVVLQRQVCPDLLRKFAEVGFIHAEATVHLLRSEGVELNDRAIPPEDLSQHPAGYVPEPPEVNAEWITYRTWIESLSRCAMNNWLRSAEIGQEIQEAWIVQNAVVYVLNHNHHLILAGRQKELVDALYHLLSIVKATGHSGDPVMLVTLCNTLARGLIISWIPVQAAEKSRKFMRPNAFHSPLDAGATSEIKTAVEVCEFALNLTNGSAPEETVPTGTRQQLIATWVKAKQLLQQQIGPRLGTEEQGTNEDVSSVTRVLVALEMYSCNGLGLMDFTVPSLAQLVKMASECNWSDPLVELQTLTRLTHFAHAARDHETTMACAHRALEMGIKYLKKFGPEESRLVAEMLCTATAIQGRSIMENLKGRKQLRLVAAKAFTESARFGGIAGSSALVMLAARHYWNAWLPLLSSAVYRKKAKGALKRLIGIINKTEARKQEKGKTLLLHQWPTADFQGGGTTEGYFLPGAEDDLALRAALYGLLFHSHADQDDWEGGLKVLDEAVQVLPRTAHRLLIFKHMVIVKAKLGQNFSMEIQKFKAESEDYLARMWHRLALNSPSVSGELACYNNAIQALQKPEMEWQKVEYLMEFGQWLHHRHFPLEDVVFHLRWAVEILLAMKPPGDVPEPQPTPDGEYVAVEMPPRSPVSEAEEAVSLEQLRSVRQLEALARVHILLALVLSPGAEGYEDCCLAAYAFFRHIWQVSLMTAGKSVLENRPLAATSSHLLLPKKEKENERSKEKEKERSKEKENERSKEKDKEKGKEEKVKEPKQSQSPAPIKQLEDLPMSIEEWASYSCPEEVLSVLKQDRSDSTVNPSSIQKPTYSLYFLDHLVKALQKMCLHELTVPVLQLGVLISDSVVGSKGLSDLYHLRLAHACSELKLREAAARHEEAVGQVCVSELEQASCRKEIALKKEKNKEPLLEESLPALNEQTLPVQPGEIKPLDAKDKILKMNGETGRDLDGTSFPHLWMLKAEVLLEMNLYQPARLLLSEAYLAFQELDEPCAEAQCLLLLAQLANKEKNYGQAKKMIAQAQHLGGSEEFWYNSTLTLAEALLSMEHSGREATVCHIFQKLINAFKILKKERPNRLPLLEFMITDLEARCLSLRVRVAQHSAVTEPTECSLLLKEMDDGLLEIERKFIDCGCKENCVDVKLERAKIKRLRAQNEKDEEQKTAYYLEAYGLAQGAVAEEEGRLHSIQGLYGLAQGAMAEEEGRLHSVQGLLSLQDLQNVNTPLMRKLARLKLGLVEMALDMLQFIWEEAHGQQSEQGSLEKLLADYLQNTSDYTSVGLQWFTLKRTLAHGALAQLGSLQPLSVGCVEIRARLLGLAGRALHLLAMQADPVHPTCYWEAGPSVGAKLSGLKSLELEVEEEGATKSSRDPPASRAAPEEHCRRGEDLKRRMVLAQQYLAQASEVLLQCLQVALGSGLLDVAAAASLEMVECVGTLDPATTCQFLALSQSCSASETMRDVLLAATANTSSSQLAALLQLQHQLRCQDRTTTSLGARVEQRLAAVSKAWQNLCVTEQHFNLLNEMPPTFWILFLHLSGDRSRLYGAAYEKPKFITAAKGKVQAVGGSCKVMRLAISPTAFSHLLACAQQFRKQTQAQVYSEDMALNIGSEPEGLQVEEKERPVQRLSSVLGPLEELLQPLFPLLSLSKARVQTPAVVADSGKSKGKDKERKTSTGQHSTVQPEVADKIVLVADRHLLELPLEGLSVFDEGTISSVSREFSLQMLWNRLHKEETEGGVKKEGRSRDPKKRSLAKKGRKGSIPRTIPPDCIIVDSDNFKFVVDPYEEAQGPEMLTPVSITQDILERFQDTFTSRWAGHLGSKHFPSQAQWEQALGSCSGFFFYGMESFLSHILVERLVAMNLQECQVAVLLDLARSYQSLKRHMESVEHRRSVGRWEANWRNSASPSEDEWRRGGEPRRGFSDLEGQAAAAPKLRAPSHHAQLGPVWAAAPSHRVVQAWTCLPSAAGAPALASALGSAPLPTHPHLPAPIPSSQLALPFLGLSPALGAASARDPPPATSRKAAAWTSSSACLCAPWGLRRGWSCVSSRGQDKGGLPLAALVLSCLDQKTIQTVSLFLI"},{"id":"SEQ_00633","a":"P46937","g":"YAP1","d":"Transcriptional coactivator YAP1","L":504,"m":[{"c":"PLPxGWExAxToxG[QE]xYΩψNHx[DN]xTT[ST]WxDPR","u":32,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 32-aa repeats separated by a 28-aa linker, sharing invariant PLP, GWE, A, T, G, YΩψNH, TT[ST]W, and DPR anchor motifs across 18 identical and multiple physicochemically conserved positions.","i":[[172,203,"PLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPR"],[231,262,"PLPDGWEQAMTQDGEIYYINHKNKTTSWLDPR"]]}],"s":"MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL"},{"id":"SEQ_00644","a":"P43146","g":"DCC","d":"Netrin receptor DCC","L":1447,"m":[{"c":"P(x){14,18}ψxψ[ST]W(x){12,16}[FY](x){26,31}LxxxxxYxφxφx[AV]xxxx[GR]x[GS]xxxxxxxxx[TR]","u":"90-98","sp":"dispersed","x":"structured_like","cf":"high","why":"Six consecutive ~90-98 aa structured repeats separated by short-to-moderate variable linkers (4-27 aa), anchored by an N-terminal proline, conserved ψxψ[ST]W motif, central aromatic residue, invariant LxxxxxY, and C-terminal Yxφxφx[AV]xxxx[GR]x[GS] signature.","i":[[429,521,"PSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVAT"],[528,617,"PGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVT"],[622,715,"PSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAET"],[726,815,"PDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTR"],[843,939,"PMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATT"],[944,1041,"PTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRT"]]},{"c":"[LP]xFLox[PT][SE]xφx[AT]φx[GS]xxφxφxC(x){7,8}PxφxW(x){29,36}DxGφYxC(x){15,17}φψ","u":"87-97","sp":"dispersed","x":"structured_like","cf":"high","why":"Four consecutive ~87-97 aa structured repeats in the N-terminal region separated by 1-8 aa linkers, defined by an ungapped 22-aa [LP]xFL...C segment, invariant PxφxW motif, and conserved DxGφYxC cystine-containing signature.","i":[[40,136,"LRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAV"],[140,231,"LRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRIL"],[240,329,"LYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLV"],[331,417,"PWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIV"]]}],"s":"MENSLRCVWVPKLAFVLFGASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGKRKGSQKDLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGSKSTSHSGQDTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRSQSVSEGPTTQQPPMLPPSQPEHSSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSANVYEQDDLSEQMASLEGLMKQLNAITGSAF"},{"id":"SEQ_00674","a":"A2A3L6","g":"TTC24","d":"Tetratricopeptide repeat protein 24","L":582,"m":[{"c":"xxxxxxxxLG(x){4,11}[AG]xxxxxxAxxxxxxx[GRP]","u":"30-37","sp":"dispersed","x":"structured_like","cf":"high","why":"Six 30-37 aa helix-turn-helix structural repeats anchored by an invariant LG dipeptide in the first helix, a 4- or 11-residue inter-helical turn, and a conserved [AG]xxxxxxA core with a [GRP] C-cap in the second helix.","i":[[77,113,"VLQACAFNLGAAYVETGDPARGLELLLRAHPEEKAQG"],[122,151,"NVALAYHALGELPQALAWYHRALGHYQPQG"],[159,188,"KMGACYQALGQPELAAHCLQEASQAYAQER"],[271,307,"EQATVLRNLGMAHNALGNYQEAREFHQKAADLHGSVG"],[318,347,"SLAFALSQLGDHKAARDNYLHALQAARDSG"],[351,387,"GQWQACEGLGAAAARLGQYDQALKYYKEALAQCQKEP"]]}],"s":"MSSPNPEDVPRRPEPEPSSSNKKKKKRKWLRQEASIQALTRAGHGALQAGQNHEALNNFQRAFLLASKAPQTRDTPVLQACAFNLGAAYVETGDPARGLELLLRAHPEEKAQGRRHGDQCFNVALAYHALGELPQALAWYHRALGHYQPQGDQGEAWAKMGACYQALGQPELAAHCLQEASQAYAQERQLRAAALALGAAAGCMLKSGRHRVGEVVQVLEKSRRLAERSTERRLLGHLYNDLGLGYSQLQLFPLAVEAFLQALPLCWVPGEQATVLRNLGMAHNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQAARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEALAQCQKEPDSVRERLVAKLADTVRTRLAQVGLVQTHTLTSAPGRLQAPGGASQAEGTPAKAGSSTAGVQHRSSSGWEDEEFEEGHQKKKEERSANVPVRAGPGRPELCFLPGTVNHSHHLASSCPTFTKHTPCRGTVLGKASIYSPGPRAHLPFVGPGPPRAEYPSILVPNGPQANRSSRWPRESLSRSRQRRPMESGICTIV"},{"id":"SEQ_00683","a":"A6NFR6","g":"SPATA31J1","d":"Protein 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gaps.","i":[[1682,1731,"LKPCAVDTLVELQMMMETIQFIENKKRHLEGEPTLRSLLWYDETLYAELL"],[2054,2103,"LKPEAIEMYIEIVMVSETIHFLKNSIAKKLDKQRFRGMLWFDLSLLPELV"]]}],"s":"MPSDAKDSVNGDLLLNWTSLKNILSGLNASFPLHNNTGSSTVTTSKSIKDPRLMRREESMGEQSSTAGLNEVLQFEKSSDNVNSEIKSTPSNSASSSEVVPGDCAVLTNGLDTPCFKTSVNDSQSWAHNMGSEDYDCIPPNKVTMAGQCKDQGNFSFPISVSNVVSEVENQNHSEEKAQRAQQESGNAYTKEYSSHIFQDSQSSDLKTIYQTGCQTSTVFPLKKKVSIDEYLQNTGKMKNFADLEDSSKHEEKQTSWKEIDNDFTNETKISPIDNYIVLHQEYKESESHNSFGKSCDKILITQELEITKSSTSTIKDKDELDHLALEWQITPSFESLSQKHPQHSVEYEGNIHTSLAIAQKLMELKLGKINQNYASIITEAFPKPKDIPQAKEMFIDTVISSYNIETAHDSSNCSITREHICVHRKNENEPVSLENIQRDYKETAYVEDRGQDHNLFCNSQLSNDIWLNVNFKKQTDRENQNEAKENSASCVENNIENIYGDKKQDSHTNENFSNIDEKEDKNYHNIEILSSEEFSTKFNLICREDNAVSAATALLESEEDTISAVKQKDTENTGRSVEHLASTTFPKTASSSVCVASNAAIQIASATMPALSLNNDDHQIYQFKETCSSESPDFGLLVKHRVSDCEIDTDKNKSQESFHQSINENLVLQSIELESEIEIELEDCDDAFIFQQDTHSHENMLCEEFVTSYKALKSRISWEGLLALDNGEMEVLESTTGRENSDQHYSKESNYFYSSTQNNETELTSPILLPDLQIKITNIFRPGFSPTADSLALKDSFCTHVTEATKPEINKEDGEILGFDIYSQPFGENADYPCEDKVDNIRQESGPVSNSEISLSFDLSRNTDVNHTSENQNSESLFTEPSNVTTIDDGSRCFFTKSKTDYNDTKNKKEVESRISKRKLHISSRDQNIPHKDLRRHKIYGRKRRLTSQDSSECFSSLSQGRIKTFSQSEKHIKSVLNILSDEASLCKSKCLSRKLDKAVVHLKKAHRRVHTSLQLITKVGEERKGPLPKSYAIICNNFWESCDLQGYSSVSQRKYYSTKHFSSKRKYDKRRKKRAPKADISKSLTHVSKHKSYKTSGEKKCLSRKSMASSVSKSHPTTSHMGEFCNQEHPESQLPVSSTSQSTSQSVYYNSSVSNPSLSEEHQPFSGKTAYLFSPDHSDEKLIEKENQIDTAFLSSTSKYEKLEKHSANHNVKDATKENSCDANEVINESNSVSLSCIKENINSSTGNDCDATCIGHTKAKTDVLISVLDSNVKHFLNDLYQQGNLILSDCKRNLEVKWTDPIERPKQNIITGNFLMGPLNLTLIASKKYSIPQLSAAAVTDSEGESSKSYLDKQRILTVDSFAASSTVPHCEQSCREKELLKTEQCSSGNCLHTDGNETNVTENYELDVASGTEEDKSYGENIVELSSSDSSLLLKDNVKGSSSETCIVKKDTEDRITWKVKQAEKAKDSVYKRSMTEGSTVNTEYKNQKNQISEESCLNEKIITTNLIDSHLSTKNTTTESVPLKNTVSNPLNKREKKGEIKVSKDSQSDLTLHSEIAYISKPGILGVNHTPILPAHSETCKVPTLLKKPASYVSDFKEKHCSANHTALIANLSQILQRADEASSLQILQEETKVCLNILPLFVEAFERKQECSVEQILISRELLVDQNLWNNCKHTLKPCAVDTLVELQMMMETIQFIENKKRHLEGEPTLRSLLWYDETLYAELLGKPRGFQQQSNFYPGFQGRLKYNAFCELQTYHDQLVELLEETKREKNSYYVFLKYKRQVNECEAIMEHCSDCFDFSLSVPFTCGVNFGDSLEDLEILRKSTLKLINVCGDSPKVHSYPGKQDHLWIIIEMISSKVNFIKNNEAVRVKISLYGLEHIFFDAAKNLVWKERTQSFSKKYSQKKDEERLLRVNKCAFSKLQKIYDTLSKDLNNEPISPIGLEEDTIIASRKSDHPINEATISIENSKFNSNLLAHPDICCISEILDQAEFADLKKLQDLTLRCTDHLEILKKYFQMLQDNNMDNIFITEENVLDVVINHSHEAIILKPEAIEMYIEIVMVSETIHFLKNSIAKKLDKQRFRGMLWFDLSLLPELVQCQEKMASFSFLKDNSTDVCLWKVIETAVSELKKDLDIICKYNEAVNCSYAIHLLSRELQELSEIKKLLKKSKYFISTYIDFVPYIASINYGSTVTELEYNYNQFSTLLKNVMSAPRKDLGKMAHIRKVMKTIEHMKMICTKNAELTISFFLCQMLYNRRKILQLKRKEKMNIHIVKPGENNNKFSISTMLPPVSECINKNISNSSKKRPSTVDKCEDSQEQQQDTTVSSCKKLKVDMKDVTKINREKATFKHPRTTGSHPKSENKIVPSSCDSLKRNHLTPKKVEMQRSLPGSLLPLENPKDTCASKSESKIDLTVSSDHFSGQQENLNSMKKRNVNFSAAETKSDKKDCAAFAICDQKSVHGTFSPDHGTLLQKFLKNSPDPTQKSCLSDINPETDVSLVPDASVLSKPIFCFVKDVHPDLEMNDTVFELQDNDIVNSSIKNSSCMTSPEPICIQNKIPTLQINKLQPTETESEDKYMKDTLNPNTVHTFGASGHITLNVNQGAEYSLSEQQNDKNSKVLMQNAATYWNELPQSACNPTYNSSEHLFGTSYPYSAWCVYQYSNSNGNAITQTYQGITSYEVQPSPSGLLTTVASTAQGTHSNLLYSQYFTYFAGEPQANGFVPVNGYFQSQIPASNFRQPIFSQYASHQPLPQATYPYLPNRFVPPEVPWVYAPWHQESFHPGH"},{"id":"SEQ_00696","a":"Q9UIS9","g":"MBD1","d":"Methyl-CpG-binding 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linkers.","i":[[175,217,"GCGECAACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLR"],[224,264,"GCGVCRGCQTQEDCGHCPICLRPPRPGLRRQWKCVQRRCLR"],[337,379,"KCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQ"]]}],"s":"MAEDWLDCPALGPGWKRREVFRKSGATCGRSDTYYQSPTGDRIRSKVELTRYLGPACDLTLFDFKQGILCYPAPKAHPVAVASKKRKKPSRPAKTRKRQVGPQSGEVRKEAPRDETKADTDTAPASFPAPGCCENCGISFSGDGTQRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGECAACQVTEDCGACSTCLLQLPHDVASGLFCKCERRRCLRIVERSRGCGVCRGCQTQEDCGHCPICLRPPRPGLRRQWKCVQRRCLRGKHARRKGGCDSKMAARRRPGAQPLPPPPPSQSPEPTEPHPRALAPSPPAEFIYYCVDEDELQPYTNRRQNRKCGACAACLRRMDCGRCDFCCDKPKFGGSNQKRQKCRWRQCLQFAMKRLLPSVWSESEDGAGSPPPYRRRKRPSSARRHHLGPTLKPTLATRTAQPDHTQAPTKQEAGGGFVLPPPGTDLVFLREGASSPVQVPGPVAASTEALLQEAQCSGLSWVVALPQVKQEKADTQDEWTPGTAVLTSPVLVPGCPSKAVDPGLPSVKQEPPDPEEDKEENKDDSASKLAPEEEAGGAGTPVITEIFSLGGTRFRDTAVWLPRSKDLKKPGARKQ"},{"id":"SEQ_00697","a":"Q13444","g":"ADAM15","d":"Disintegrin and metalloproteinase domain-containing protein 15","L":863,"m":[{"c":"PxPPx+PLP[AP]DPxx+","u":15,"sp":"periodic","x":"disordered_like","cf":"high","why":"Three C-terminal disordered 15-aa proline-rich motifs anchored by invariant P, L, and D positions plus two conserved basic (+) positions (PxPPx+PLP[AP]DPxx+), spaced periodically by exact 9-aa linkers.","i":[[767,781,"PAPPSRPLPPDPVSK"],[791,805,"PNPPTRPLPADPVVR"],[815,829,"PPPPRKPLPADPQGR"]]}],"s":"MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKQASALSFPAPPSRPLPPDPVSKRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPPPPTVSSLYL"},{"id":"SEQ_00708","a":"P0CG41","g":"CTAGE8","d":"cTAGE family member 8","L":777,"m":[{"c":"[RG][GP][GP][FLP]φ[PR]","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five non-overlapping 6-aa repeats clustered in the proline/glycine-rich C-terminal disordered region (residues 690-773), anchored by an N-terminal R/G-G/P-G/P core (three exact RGP starts), an invariant hydrophobic residue at position 5 (I, F, M, Y), and C-terminal P/R.","i":[[690,695,"GPGFIP"],[702,707,"RGPLFP"],[711,716,"RGPFMR"],[717,722,"RGPPFP"],[768,773,"RPGFYP"]]},{"c":"RxφΩPP[PR]","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 7-aa motifs in the C-terminal disordered tail (residues 605-759) defined by an invariant N-terminal R, a hydrophobic-aromatic pair (MF, YF, IY), a fixed PP dipeptide, and a C-terminal P/R.","i":[[606,612,"RMMFPPP"],[734,740,"RGYFPPR"],[753,759,"RNIYPPR"]]}],"s":"MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHSPCSPSPLGRPSSETRAFPSPQTLLEDPLRLSPVLPGGGGRGPSSPGNPLDHQITNERGEPSYDRLIDPHRAPSDTGSLSSPVEQDRRMMFPPPGQSYPDSTLPPQREDRFYSNSERLSGPAEPRSFKMTSLDKMDRSMPSEMESSRNDAKDDLGNLNVPDSSLPAENEATGPGFIPPPLAPVRGPLFPVDTRGPFMRRGPPFPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYLHPRPGFYPNPTF"},{"id":"SEQ_00710","a":"Q96JK2","g":"DCAF5","d":"DDB1- and CUL4-associated factor 5","L":942,"m":[{"c":"xx[GH]xxxxxxφxx[FS](x){4,6}xφφ[ST][GS]x--(x){2,3}φxφ[WH]xψx","u":"35-36","sp":"periodic","x":"structured_like","cf":"high","why":"Seven periodic ~35-36 aa structured repeats in the N-terminal half (residues 49-363) separated by 7-18 aa linkers, anchored by N-terminal GH/hydrophobic-F/S motifs, a central [ST][GS]xDD triad, and a C-terminal hydrophobic cluster preceding a conserved W/H/Y residue.","i":[[49,84,"LLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHME"],[96,131,"LKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVE"],[139,173,"FAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIR"],[184,218,"ANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIR"],[228,263,"GGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIH"],[275,310,"GYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIP"],[329,363,"LKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPY"]]}],"s":"MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPFCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQEDPRMMAFFDSLVRREIEGWSSDSDSDLSESTILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPTCEDAASRQQRLSALRRYQDKRLLALSNESDSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQKTTREDKPSAPIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGETSLVTGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVEHPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSPGHSDTDRDNSSLTGTLLHKDCCGSEMACETPNAGTREDPTDTPATDSSRAVHGHSGLKRQRIELEDTDSENSSSEKKLKT"},{"id":"SEQ_00723","a":"A8MUU9","g":"YV023_HUMAN","d":"Putative uncharacterized protein ENSP00000383309","L":505,"m":[{"c":"[TS]P[PS][RT]ASL[TR]R","u":9,"sp":"tandem","x":"disordered_like","cf":"high","why":"Extensive head-to-tail tandem array of 54 highly conserved 9-residue disordered-like units spanning nearly the entire protein (residues 1-491, interrupted only by a single 5-aa partial copy ASRTR at 208-212), anchored by invariant C-terminal R and strongly conserved P2, [RT]4, A5, S6, L7 positions.","i":[[1,9,"MPPTASLTR"],[10,18,"SPPTASQTR"],[19,27,"TLPRASRTR"],[28,36,"TPPRASLTR"],[37,45,"SPPTASLRR"],[46,54,"TPSRASRTR"],[55,63,"TPPRASLKR"],[64,72,"TPSRASLTR"],[73,81,"TLSRASLTR"],[82,90,"LKSRASHTR"],[91,99,"TPSRASLTR"],[100,108,"TPPTASRTR"],[109,117,"SLPRASRTR"],[118,126,"TPPRTSQRR"],[127,135,"MPPRTSQTR"],[136,144,"TPPRASLRR"],[145,153,"TPSRASRTR"],[154,162,"TPPRASLRR"],[163,171,"TPSRASLTR"],[172,180,"TPSRASLTR"],[181,189,"LKSRASHTR"],[190,198,"TPSRASLTR"],[199,207,"TPPTASLTR"],[213,221,"TPPRTSQTR"],[222,230,"TPPRASLRR"],[231,239,"TPSRASLTR"],[240,248,"TPSRASLTR"],[249,257,"TPSRASLTR"],[258,266,"LKSRASHTR"],[267,275,"TPSRASLTR"],[276,284,"TPPTASLTR"],[285,293,"TPPTASLTR"],[294,302,"TPPRASLTR"],[303,311,"SPPRASLTR"],[312,320,"TPPTASLTR"],[321,329,"SPPTASLTR"],[330,338,"TPPRASLTR"],[339,347,"SPPRASLTR"],[348,356,"TPSTASLTR"],[357,365,"TPSRASLTR"],[366,374,"SKSRASHTR"],[375,383,"TPSRASLTR"],[384,392,"TPPRASLTR"],[393,401,"TPPRASLTR"],[402,410,"SPPTASLTR"],[411,419,"MPPTASLTR"],[420,428,"SPPRASLTR"],[429,437,"TPPRASLTR"],[438,446,"SPSTASLTR"],[447,455,"TPPGTWLRR"],[456,464,"TPPRTSLTR"],[465,473,"TPPTASLTR"],[474,482,"TPYTASLTR"],[483,491,"TPYTASLMR"]]}],"s":"MPPTASLTRSPPTASQTRTLPRASRTRTPPRASLTRSPPTASLRRTPSRASRTRTPPRASLKRTPSRASLTRTLSRASLTRLKSRASHTRTPSRASLTRTPPTASRTRSLPRASRTRTPPRTSQRRMPPRTSQTRTPPRASLRRTPSRASRTRTPPRASLRRTPSRASLTRTPSRASLTRLKSRASHTRTPSRASLTRTPPTASLTRASRTRTPPRTSQTRTPPRASLRRTPSRASLTRTPSRASLTRTPSRASLTRLKSRASHTRTPSRASLTRTPPTASLTRTPPTASLTRTPPRASLTRSPPRASLTRTPPTASLTRSPPTASLTRTPPRASLTRSPPRASLTRTPSTASLTRTPSRASLTRSKSRASHTRTPSRASLTRTPPRASLTRTPPRASLTRSPPTASLTRMPPTASLTRSPPRASLTRTPPRASLTRSPSTASLTRTPPGTWLRRTPPRTSLTRTPPTASLTRTPYTASLTRTPYTASLMRMPYMTSLMTPYKAR"},{"id":"SEQ_00727","a":"Q8TD16","g":"BICD2","d":"Protein bicaudal D homolog 2","L":824,"m":[{"c":"GR[TR]SP","u":5,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three closely clustered copies in the central Gly/Pro/Ser-rich disordered hinge (residues 565-583, separated by 1- and 3-residue linkers) share fixed G1, R2, S4, and P5 anchors with position 3 constrained to T or R.","i":[[565,569,"GRTSP"],[571,575,"GRTSP"],[579,583,"GRRSP"]]}],"s":"MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPSL"},{"id":"SEQ_00739","a":"Q9BYB0","g":"SHANK3","d":"SH3 and multiple ankyrin repeat domains protein 3","L":1806,"m":[{"c":"xxxx[GS]x[TQC][APE]φxx[ASC]xxxxxxxx[LAC]xxψ[LK](x){2,3}[GHK][AD]xx[DGV]φ","u":"33-34","sp":"tandem","x":"structured_like","cf":"high","why":"Six head-to-tail tandem 33-34 aa repeats (residues 220-419) form a structured helical repeat array anchored by a conserved [GS]x[TQC][APE]φxx[ASC] motif, a hydrophobic helix core ([LAC]xxψ[LK]), a 2-3 aa turn, and a C-terminal [GHK][AD]xx[DGV]φ signature (with minor polar substitutions in the 6th C-capping repeat). Extensive proline/glycine/serine-rich disordered regions (residues 1-80, 424-550, and 750-1740) contain compositional-bias tracts (poly-A, PA, GP, RS/SP, and P-runs) without any >=3-copy multi-position anchored repeat motif.","i":[[220,253,"DPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDF"],[254,286,"RTRDGLTAVHCATRQRNAAALTTLLDLGASPDY"],[287,320,"KDSRGLTPLYHSALGGGDALCCELLLHDHAQLGI"],[321,353,"TDENGWQEIHQACRFGHVQHLEHLLFYGADMGA"],[354,386,"QNASGNTALHICALYNQESCARVLLFRGANRDV"],[387,419,"RNYNSQTAFQVAIIAGNFELAEVIKTHKDSDVV"]]}],"s":"MQLSRAAAAAAAAPAEPPEPLSPAPAPAPAPPGPLPRSAADGAPAGGKGGPGRRAESPGAPFPGASGPGPGPGAGMDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDVVPFRETPSYAKRRRLAGPSGLASPRPLQRSASDINLKGEAQPAASPGPSLRSLPHQLLLQRLQEEKDRDRDADQESNISGPLAGRAGQSKISPSGPGGPGPAPGPGPAPPAPPAPPPRGPKRKLYSAVPGRKFIAVKAHSPQGEGEIPLHRGEAVKVLSIGEGGFWEGTVKGRTGWFPADCVEEVQMRQHDTRPETREDRTKRLFRHYTVGSYDSLTSHSDYVIDDKVAVLQKRDHEGFGFVLRGAKAETPIEEFTPTPAFPALQYLESVDVEGVAWRAGLRTGDFLIEVNGVNVVKVGHKQVVALIRQGGNRLVMKVVSVTRKPEEDGARRRAPPPPKRAPSTTLTLRSKSMTAELEELASIRRRKGEKLDEMLAAAAEPTLRPDIADADSRAATVKQRPTSRRITPAEISSLFERQGLPGPEKLPGSLRKGIPRTKSVGEDEKLASLLEGRFPRSTSMQDPVREGRGIPPPPQTAPPPPPAPYYFDSGPPPAFSPPPPPGRAYDTVRSSFKPGLEARLGAGAAGLYEPGAALGPLPYPERQKRARSMIILQDSAPESGDAPRPPPAATPPERPKRRPRPPGPDSPYANLGAFSASLFAPSKPQRRKSPLVKQLQVEDAQERAALAVGSPGPGGGSFAREPSPTHRGPRPGGLDYGAGDGPGLAFGGPGPAKDRRLEERRRSTVFLSVGAIEGSAPGADLPSLQPSRSIDERLLGTGPTAGRDLLLPSPVSALKPLVSGPSLGPSGSTFIHPLTGKPLDPSSPLALALAARERALASQAPSRSPTPVHSPDADRPGPLFVDVQARDPERGSLASPAFSPRSPAWIPVPARREAEKVPREERKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPSRLGGAEEERPGTPELAPAPMQSAAVAEPLPSPRAQPPGGTPADAGPGQGSSEEEPELVFAVNLPPAQLSSSDEETREELARIGLVPPPEEFANGVLLATPLAGPGPSPTTVPSPASGKPSSEPPPAPESAADSGVEEADTRSSSDPHLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKPKLKSPLGKGPVTFRDPLLKQSSDSELMAQQHHAASAGLASAAGPARPRYLFQRRSKLWGDPVESRGLPGPEDDKPTVISELSSRLQQLNKDTRSLGEEPVGGLGSLLDPAKKSPIAAARLFSSLGELSSISAQRSPGGPGGGASYSVRPSGRYPVARRAPSPVKPASLERVEGLGAGAGGAGRPFGLTPPTILKSSSLSIPHEPKEVRFVVRSVSARSRSPSPSPLPSPASGPGPGAPGPRRPFQQKPLQLWSKFDVGDWLESIHLGEHRDRFEDHEIEGAHLPALTKDDFVELGVTRVGHRMNIERALRQLDGS"},{"id":"SEQ_00754","a":"A6NMZ7","g":"COL6A6","d":"Collagen alpha-6(VI) chain","L":2263,"m":[{"c":"-φφφxφDxS(x){95,112}φxφφ[ATS](x){21,24}φφ(x){42,65}C","u":"175-218","sp":"dispersed","x":"structured_like","cf":"high","why":"Nine structured ~175-218 aa globular repeats (seven arrayed N-terminal to the central collagenous G-x-y tract with 6-12 aa linkers and two C-terminal to it separated by a 22 aa linker) share a conserved N-terminal -φφφxφDxS motif, internal hydrophobic beta-strands (φxφφ[ATS] and downstream φφ), and a C-terminal cysteine.","i":[[27,222,"DVVFLVDSSDRLGSKSFPFVKMFITKMISSLPIEADKYRVALAQYSDKLHSEFHLSTFKGRSPMLNHLRKNFGFIGGSLQIGKALQEAHRTYFSAPANGRDKKQFPPILVVLASSESEDNVEEASKALRKDGVKIISVGVQKASEENLKAMATSQFHFNLRTVRDLSMFSQNMTHIIKDVIKYKEGAVDDIFVEAC"],[229,429,"DVVFLLDMSINGSEENFDYLKGFLEESVSALDIKENCMRVGLVAYSNETKVINSLSMGINKSEVLQHIQNLSPRTGKAYTGAAIKKLRKEVFSARNGSRKNQGVPQIAVLVTHRDSEDNVTKAAVNLRREGVTIFTLGIEGASDTQLEKIASHPAEQYVSKLKTFADLAAHNQTFLKKLRNQITHTVSVFSERTETLKSGC"],[436,611,"DIYLLIDGSGSTQATDFHEMKTFLSEVVGMFNIAPHKVRVGAVQYADSWDLEFEINKYSNKQDLGKAIENIRQMGGNTNTGAALNFTLSLLQKAKKQRGNKVPCHLVVLTNGMSKDSILEPANRLREEHIRVYAIGIKEANQTQLREIAGEEKRVYYVHDFDALKDIRNQVVQEIC"],[622,796,"DIMFLVDSSGSIGPENFSKMKTFMKNLVSKSQIGPDRVQIGVVQFSDINKEEFQLNRFMSQSDISNAIDQMAHIGQTTLTGSALSFVSQYFSPTKGARPNIRKFLILITDGEAQDIVKEPAVVLRQEGVIIYSVGVFGSNVTQLEEISGRPEMVFYVENFDILQRIEDDLVFGIC"],[809,987,"DVVFVIDSSGSIDYDEYNIMKDFMIGLVKKADVGKNQVRFGALKYADDPEVLFYLDDFGTKLEVISVLQNDQAMGGSTYTAEALGFSDHMFTEARGSRLNKGVPQVLIVITDGESHDADKLNATAKALRDKGILVLAVGIDGANPVELLAMAGSSDKYFFVETFGGLKGIFSDVTASVC"],[1000,1176,"DLVFLMDGSTSIQPNDFKKMKEFLASVVQDFDVSLNRVRIGAAQFSDTYHPEFPLGTFIGEKEISFQIENIKQIFGNTHIGAALREVEHYFRPDMGSRINTGTPQVLLVLTDGQSQDEVAQAAEALRHRGIDIYSVGIGDVDDQQLIQITGTAEKKLTVHNFDELKKVNKRIVRNIC"],[1187,1383,"DVVVGFDVSTQEKGQTLLEGQPWMETYLQDILRAISSLNGVSCEVGTETQVSVAFQVTNAMEKYSPKFEIYSENILNSLKDITVKGPSLLNANLLDSLWDTFQNKSAARGKVVLLFSDGLDDDVEKLEQKSDELRKEGLNALITVALDGPADSSDLADLPYIEFGKGFEYRTQLSIGMRELGSRLSKQLVNVAERTC"],[1757,1942,"ELVFALDHSRDVTEQEFERMKEMMAFLVRDIKVRENSCPVGAHIAILSYNSHARHLVRFSDAYKKSQLLREIETIPYERSSASREIGRAMRFISRNVFKRTLPGAHTRKIATFFSSGQSADAHSITTAAMEFGALEIIPVVITFSNVPSVRRAFAIDDTGTFQVIVVPSGADYIPALERLQRCTFC"],[1965,2182,"DAAFLLDASRNMGSAEFEDIRAFLGALLDHFEITPEPETSVTGDRVALLSHAPPDFLPNTQKSPVRAEFNLTTYRSKRLMKRHVHESVKQLNGDAFIGHALQWTLDNVFLSTPNLRRNKVIFVISAGETSHLDGEILKKESLRAKCQGYALFVFSLGPIWDDKELEDLASHPLDHHLVQLGRIHKPDHSYGVKFVKSFINSIRRAINKYPPINLKIKC"]]}],"s":"MMLLILFLVIICSHISVNQDSGPEYADVVFLVDSSDRLGSKSFPFVKMFITKMISSLPIEADKYRVALAQYSDKLHSEFHLSTFKGRSPMLNHLRKNFGFIGGSLQIGKALQEAHRTYFSAPANGRDKKQFPPILVVLASSESEDNVEEASKALRKDGVKIISVGVQKASEENLKAMATSQFHFNLRTVRDLSMFSQNMTHIIKDVIKYKEGAVDDIFVEACQGPSMADVVFLLDMSINGSEENFDYLKGFLEESVSALDIKENCMRVGLVAYSNETKVINSLSMGINKSEVLQHIQNLSPRTGKAYTGAAIKKLRKEVFSARNGSRKNQGVPQIAVLVTHRDSEDNVTKAAVNLRREGVTIFTLGIEGASDTQLEKIASHPAEQYVSKLKTFADLAAHNQTFLKKLRNQITHTVSVFSERTETLKSGCVDTEEADIYLLIDGSGSTQATDFHEMKTFLSEVVGMFNIAPHKVRVGAVQYADSWDLEFEINKYSNKQDLGKAIENIRQMGGNTNTGAALNFTLSLLQKAKKQRGNKVPCHLVVLTNGMSKDSILEPANRLREEHIRVYAIGIKEANQTQLREIAGEEKRVYYVHDFDALKDIRNQVVQEICTEEACKEMKADIMFLVDSSGSIGPENFSKMKTFMKNLVSKSQIGPDRVQIGVVQFSDINKEEFQLNRFMSQSDISNAIDQMAHIGQTTLTGSALSFVSQYFSPTKGARPNIRKFLILITDGEAQDIVKEPAVVLRQEGVIIYSVGVFGSNVTQLEEISGRPEMVFYVENFDILQRIEDDLVFGICSPREECKRIEVLDVVFVIDSSGSIDYDEYNIMKDFMIGLVKKADVGKNQVRFGALKYADDPEVLFYLDDFGTKLEVISVLQNDQAMGGSTYTAEALGFSDHMFTEARGSRLNKGVPQVLIVITDGESHDADKLNATAKALRDKGILVLAVGIDGANPVELLAMAGSSDKYFFVETFGGLKGIFSDVTASVCNSSKVDCEIDKVDLVFLMDGSTSIQPNDFKKMKEFLASVVQDFDVSLNRVRIGAAQFSDTYHPEFPLGTFIGEKEISFQIENIKQIFGNTHIGAALREVEHYFRPDMGSRINTGTPQVLLVLTDGQSQDEVAQAAEALRHRGIDIYSVGIGDVDDQQLIQITGTAEKKLTVHNFDELKKVNKRIVRNICTTAGESNCFVDVVVGFDVSTQEKGQTLLEGQPWMETYLQDILRAISSLNGVSCEVGTETQVSVAFQVTNAMEKYSPKFEIYSENILNSLKDITVKGPSLLNANLLDSLWDTFQNKSAARGKVVLLFSDGLDDDVEKLEQKSDELRKEGLNALITVALDGPADSSDLADLPYIEFGKGFEYRTQLSIGMRELGSRLSKQLVNVAERTCCCLFCKCIGGDGTMGDPGPPGKRGPPGFKGSEGYLGEEGIAGERGAPGPVGEQGTKGCYGTKGPKGNRGLNGQEGEVGENGIDGLNGEQGDNGLPGRKGEKGDEGSQGSPGKRGTPGDRGAKGLRGDPGAPGVDSSIEGPTGLKGERGRQGRRGWPGPPGTPGSRRKTAAHGRRGHTGPQGTAGIPGPDGLEGSLGLKGPQGPRGEAGVKGEKGGVGSKGPQGPPGPGGEAGNQGRLGSQGNKGEPGDLGEKGAVGFPGPRGLQGNDGSPGYGSVGRKGAKGQEGFPGESGPKGEIGDPGGPGETGLKGARGKMISAGLPGEMGSPGEPGPPGRKGVKGAKGLASFSTCELIQYVRDRSPGRHGKPECPVHPTELVFALDHSRDVTEQEFERMKEMMAFLVRDIKVRENSCPVGAHIAILSYNSHARHLVRFSDAYKKSQLLREIETIPYERSSASREIGRAMRFISRNVFKRTLPGAHTRKIATFFSSGQSADAHSITTAAMEFGALEIIPVVITFSNVPSVRRAFAIDDTGTFQVIVVPSGADYIPALERLQRCTFCYDVCKPDASCDQARPPPVQSYMDAAFLLDASRNMGSAEFEDIRAFLGALLDHFEITPEPETSVTGDRVALLSHAPPDFLPNTQKSPVRAEFNLTTYRSKRLMKRHVHESVKQLNGDAFIGHALQWTLDNVFLSTPNLRRNKVIFVISAGETSHLDGEILKKESLRAKCQGYALFVFSLGPIWDDKELEDLASHPLDHHLVQLGRIHKPDHSYGVKFVKSFINSIRRAINKYPPINLKIKCNRLNSIDPKQPPRPFRSFVPGPLKATLKEDVLQKAKFFQDKKYLSRVARSGRDDAIQNFMRSTSHTFKNGRMIESAPKQHD"},{"id":"SEQ_00771","a":"Q14161","g":"GIT2","d":"ARF GTPase-activating protein GIT2","L":759,"m":[{"c":"[GL]x[KT][PQ]ψ[HD]x[AS]xxxGxx[EL]x[AC][EL][LR]Lφxφ[GQ]φxxx(x){5,6}","u":"33-34","sp":"tandem","x":"structured_like","cf":"high","why":"Three head-to-tail 33-34 aa structured repeats anchored by invariant G12 and L20, conserved N-terminal [KT][PQ]ψ[HD]x[AS] motif, and a hydrophobic Lφxφ[GQ]φ core followed by a 5-6 residue loop.","i":[[133,166,"LSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEK"],[167,199,"GNTPLHVASKAGQILQAELLAVYGADPGTQDSS"],[200,232,"GKTPVDYARQGGHHELAERLVEIQYELTDRLAF"]]}],"s":"MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPDHKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDSDLSDGPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKLQTLQSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASRPEESRMRLQPFPAHIGRSALVTSSSSLPSFPSTLSWSRDESARRASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENNN"},{"id":"SEQ_00783","a":"P49746","g":"THBS3","d":"Thrombospondin-3","L":956,"m":[{"c":"D[NS]C[PRL]xx[PS]NxxQx[DN]xDx[DN]xxGDxC","u":23,"sp":"dispersed","x":"structured_like","cf":"high","why":"Seven ungapped 23-residue disulfide-flanked repeats with strictly invariant D1, C3, N8, Q11, D15, G20, D21, C23 anchors and conserved Asp/Asn/Pro positions, separated by 0-17 aa linkers.","i":[[481,503,"DNCLLTPNSGQEDADNDGVGDQC"],[517,539,"DNCRLFPNKDQQNSDTDSFGDAC"],[540,562,"DNCPNVPNNDQKDTDGNGEGDAC"],[576,598,"DNCPKVPNPLQTDRDEDGVGDAC"],[599,621,"DSCPEMSNPTQTDADSDLVGDVC"],[637,659,"DNCPQLPNSSQLDSDNDGLGDEC"],[677,699,"DNCRLVPNPNQKDSDGNGVGDVC"]]},{"c":"C(x){4,7}CxxxxxC(x){5,7}xφxC(x){1,2}CxxGφxG(x){4,17}C","u":"37-49","sp":"periodic","x":"structured_like","cf":"high","why":"Four six-cysteine structured repeat modules separated by regular 5-aa linkers, sharing invariant disulfide cysteines, a fixed 5-aa C2-C3 loop, a hydrophobic anchor before C4, and an invariant CxxGφxG motif after C5.","i":[[278,314,"CSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHC"],[320,368,"CAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVC"],[374,412,"CNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGC"],[418,455,"CHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVC"]]},{"c":"DxDxDG[IYH][PKQ][DN]","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five non-overlapping 9-residue Asp/Gly-rich motifs located immediately N-terminal to and within the linkers between the 23-aa Cys-flanked repeats, anchored by invariant D1, D3, D5, G6 and conserved [IYH][PKQ][DN] positions.","i":[[458,466,"DTDIDGYPD"],[506,514,"DADGDGIKN"],[565,573,"DVDGDGIPN"],[626,634,"DSDGDGHQD"],[662,670,"DDDNDGIPD"]]}],"s":"METQELRGALALLLLCFFTSASQDLQVIDLLTVGESRQMVAVAEKIRTALLTAGDIYLLSTFRLPPKQGGVLFGLYSRQDNTRWLEASVVGKINKVLVRYQREDGKVHAVNLQQAGLADGRTHTVLLRLRGPSRPSPALHLYVDCKLGDQHAGLPALAPIPPAEVDGLEIRTGQKAYLRMQGFVESMKIILGGSMARVGALSECPFQGDESIHSAVTNALHSILGEQTKALVTQLTLFNQILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDVCDTNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGIPDYVPPGPDNCRLVPNPNQKDSDGNGVGDVCEDDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQATPFRAVAQPGLQLKAVTSVSGPGEHLRNALWHTGHTPDQVRLLWTDPRNVGWRDKTSYRWQLLHRPQVGYIRVKLYEGPQLVADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQYRCNDTVPEDFEPFRRQLLQGRV"},{"id":"SEQ_00802","a":"Q8NCF5","g":"NFATC2IP","d":"NFATC2-interacting protein","L":419,"m":[{"c":"PLx[ST]ψψxHφxxxψGψS[PG]x+ψxφφFxxTxLS[PG]xxxPxxLxψxx[AG]DψI-xφ","u":49,"sp":"dispersed","x":"structured_like","cf":"high","why":"Strong ungapped 49-aa C-terminal structured domain duplication separated by a 36-aa polar linker, sharing 13 identical anchor residues (PL, H, G, S, F, T, LS, P, L, D, I) and conserved hydrophobic cores (ψψ, φφF, DψI-xφ).","i":[[285,333,"PLQSVVDHMATHLGVSPSRILLLFGETELSPTATPRTLKLGVADIIDCV"],[370,418,"PLKTLMSHYEEAMGLSGRKLSFFFDGTKLSGRELPADLGMESGDLIEVW"]]}],"s":"MAEPVGKRGRWSGGSGAGRGGRGGWGGRGRRPRAQRSPSRGTLDVVSVDLVTDSDEEILEVATARGAADEVEVEPPEPPGPVASRDNSNSDSEGEDRRPAGPPREPVRRRRRLVLDPGEAPLVPVYSGKVKSSLRLIPDDLSLLKLYPPGDEEEAELADSSGLYHEGSPSPGSPWKTKLRTKDKEEKKKTEFLDLDNSPLSPPSPRTKSRTHTRALKKLSEVNKRLQDLRSCLSPKPPQGQEQQGQEDEVVLVEGPTLPETPRLFPLKIRCRADLVRLPLRMSEPLQSVVDHMATHLGVSPSRILLLFGETELSPTATPRTLKLGVADIIDCVVLTSSPEATETSQQLQLRVQGKEKHQTLEVSLSRDSPLKTLMSHYEEAMGLSGRKLSFFFDGTKLSGRELPADLGMESGDLIEVWG"},{"id":"SEQ_00811","a":"Q5T0Z8","g":"C6orf132","d":"Uncharacterized protein C6orf132","L":1188,"m":[{"c":"[PL]KA[TM][LPS]xP[AT][TI][PA]","u":10,"sp":"tandem","x":"disordered_like","cf":"high","why":"Six head-to-tail tandem 10-aa repeats in a proline/threonine-rich disordered region anchored by invariant K2-A3 and P7 positions, predominant T4 (5/6), G6 (4/6), A8 (5/6), and P10 (5/6), and constrained [PL]1 and [TI]9 choices.","i":[[633,642,"PKAMLGPAIP"],[643,652,"PKATPEPAIP"],[653,662,"PKATLWPATP"],[663,672,"PKATLGPATP"],[673,682,"LKATSGPTTP"],[683,692,"LKATSGPAIA"]]},{"c":"PP[PA]APPL","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Four exact head-to-tail tandem heptapeptide repeats in a proline-rich disordered segment anchored in strict register by invariant A4 and L7 residues flanking conserved proline positions.","i":[[390,396,"PPPAPPL"],[397,403,"PPPAPPL"],[404,410,"PPPAPPL"],[411,417,"PPAAPPL"]]}],"s":"MKKKQTVQGTFSKLFGKKHTTTPSTSLYATNPPWIFTQEAPEEGTGGFDGIYYGDNRFNTVSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSADYGFAPAAGRSPYTTTRYGSPINTFTVRPGTRHPISYVCSGAHRKATS"},{"id":"SEQ_00830","a":"Q9ULI4","g":"KIF26A","d":"Kinesin-like protein KIF26A","L":1882,"m":[{"c":"CxxCxT[KH]Lx[EQ]LxR[EQ]Aφ[KH]Lψo[GA]P","u":22,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two N-terminal 22-aa CxxC-anchored amphipathic helical repeats (residues 70-91 and 125-146, separated by a 33-aa linker) sharing 9 identical anchor positions (C1, C4, T6, L8, L11, R13, A15, L18, P22) and 8 additional constrained polar/basic/hydrophobic positions.","i":[[70,91,"CRHCHTKLVELKRQAWKLVSGP"],[125,146,"CDVCATHLQQLTREAMHLLQAP"]]}],"s":"MVGRGVPLCAAQPAVAEGGPAREPPPLLEVSPRKRLPAGPDQDPCGSRPAPEGAGAGPEQGHSAGGGGWCRHCHTKLVELKRQAWKLVSGPGTTLRDPCLSALLLDKLPAPGALPACRPEAERRCDVCATHLQQLTREAMHLLQAPASHEDLDAPHGGPSLAPPSTTTSSRDTPGPAGPAGRQPGRAGPDRTKGLAWSPGPSVQVSVAPAGLGGALSTVTIQAQQCLEGMWSVSRVNSFLPPACLAEAAVAAVAVADTVRECPPVAGPDGLSKAWGRGGVCTSALVTPTPGSVGGSTGPSAAASFFIRAMQKLSLASKRKKPHPPPPPATRGTSTYPTDFSGVLQLWPPPAPPCLLRAASKTKDNPGSIGKVKVMLRIWPAQGAQRSAEAMSFLKVDPRKKQVILYDPAAGPPGSAGPRRAATAAVPKMFAFDAVFPQDSEQAEVCSGTVADVLQSVVSGADGCIFSFGHMSLGKSYTMIGKDSSPQSLGIVPCAISWLFRLIEERRERTGTRFSVRVSAVEVCGRDQSLRDLLAEVAPGSLQDTQSPGVYLREDPVCGAQLQNQSELRAPTAEKAAFYLDAALAARSTSRAGCGEDARRSSHMLFTLHVYQYRMEKCGRGGMSGGRSRLHLIDLGSCEAAAGRAGEAAGGPLCLSLSALGSVILALVNGAKHVPYRDHRLTMLLRESLATAGCRTTMIAHVSDAPAQHAETLSTVQLAARIHRLRRKKAKYASSSSGGESSCEEGRARRPPHLRPFHPRTVALDPDRTPPCLPGDPDYSSSSEQSCDTVIYVGPGGAALSDRELTDNEGPPDFVPIIPALSRHRPSKGPRDADHFRCSTFAELQERLECMDGNEGPSGGPGGTDGAQASPARGGRKPSPPEAASPRKAVGTPMAASTPRGSSGPDTHQGTPEPCKAIVWGDQREDSSAWPELLVPEKAAVSGGRRPLPSPAPPPPQLLEACRAPEEPGGGGTDGVARTPPVGMSGQVAGSPMLPGATCPRLAAGSRCPERGLLTTTVTLQRPVELNGEDELVFTVVEELSLGALAGAGRPTSLASFDSDCSLRALASGSRPVSIISSINDEFDAYTSQAPEGGPLEGAAWAGSSHGSSISSWLSEVSVCTADSRDPTPQPRFSPDSLAGLDPGGPPALDGSLGDGSSGFLGPDRPDSPGPTWGPCPGEVAAVAPSRPGREPQAGPSRWASAAQTIHSSLPRKPRTASATTRVGCARLGQSPPGRGGLFEDPWLLRVGECDTQAASAGRAPSPTLGSPRLPEAQVMLACAQRVVDGCEVAARAARRPEAVARIPPLRRGATTLGVTTPAVSWGDAPTEVVACSGSLKASPTSKKGLAPKAGFLPRPSGAAPPAPPTRKSSLEQRSSPASAPPHAVNPARVGAAAVLRGEEEPRPSSRADHSVPRATSSLKARASKVEAAHRLAGHASLERYEGLAHSSSKGREAPGRPPRAVPKLGVPPSSPTHGPAPACRSGAAKAVGAPKPPVGGGKGRGLVAGGSRALGPSVKLSTASVTGRSPGGPVAGPRAAPRAGPSVGAKAGRGTVMGTKQALRAAHSRVHELSASGAPGRGGSSWGSADSDSGHDSGVNVGEERPPTGPALPSPYSKVTAPRRPQRYSSGHGSDNSSVLSGELPPAMGRTALFHHSGGSSGYESLRRDSEATGSASSAPDSMSESGAASPGARTRSLKSPKKRATGLQRRRLIPAPLPDTTALGRKPSLPGQWVDLPPPLAGSLKEPFEIKVYEIDDVERLQRPRPTPREAPTQGLACVSTRLRLAERRQQRLREVQAKHKHLCEELAETQGRLMLEPGRWLEQFEVDPELEPESAEYLAALERATAALEQCVNLCKAHVMMVTCFDISVAASAAIPGPQEVDV"},{"id":"SEQ_00841","a":"Q5H9B9","g":"BMP2KL","d":"Putative BMP-2-inducible kinase-like protein","L":411,"m":[{"c":"DxF[GTD]xxPF","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Seven dispersed 8-aa copies across disordered regions share invariant D1, F3, P7, and F8 anchors alongside a strongly preferred G4 (5/7 copies; T or D in the remaining two).","i":[[111,118,"DIFGAVPF"],[151,158,"DVFTKAPF"],[180,187,"DIFDFTPF"],[202,209,"DLFGLVPF"],[317,324,"DPFGAKPF"],[371,378,"DDFGAMPF"],[400,407,"DPFGAAPF"]]}],"s":"MIAPSPKSSEEEGQKDEEVLQGEQGDFNDNDTEPENLGHRPLLMDSEDEEEEEKRSSDSDYEQAKAKYSDMSPVYRDKSGSGPTQDINTILLTSAQLSSDVGVETPKQEFDIFGAVPFFAVCAQQPQQEKNEKSLPQHRFPATGLQQEEFDVFTKAPFSKKVNVQECHAVGPETHPKSIDIFDFTPFQPFLTSTSKSESNEDLFGLVPFEEIMGSQQQKVKQRSLQKLSSRQRRTKQDMSKSNGKRHHGTPTSKKKTLKPTYRTPERARRHKKVGRRVSQTSNEFVTISDSKENIGAAVTDGNDRGNVLQLEESLLDPFGAKPFHPPDLSWHPLHQGLNDIRADHNTVLPKQPRQNSLHGSFHSADVLTMDDFGAMPFTELVVQSITLQQSQQSQPVELDPFGAAPFPSKQ"},{"id":"SEQ_00845","a":"Q86YV0","g":"RASAL3","d":"RAS protein activator like-3","L":1011,"m":[{"c":"[SA]x[PS]WxR","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Four clustered 6-aa copies within a 77-residue C-terminal Pro/Arg/Ser-rich disordered segment (preceding the C-terminal coiled-coil) share invariant W4 and R6 anchors with constrained [SA]1 and [PS]3 (3/4 Pro) positions.","i":[[794,799,"SESWAR"],[832,837,"AGPWPR"],[850,855,"ARPWTR"],[865,870,"SVPWQR"]]}],"s":"MDPPSPSRTSQTQPTATSPLTSYRWHTGGGGEKAAGGFRWGRFAGWGRALSHQEPMVSTQPAPRSIFRRVLSAPPKESRTSRLRLSKALWGRHKNPPPEPDPEPEQEAPELEPEPELEPPTPQIPEAPTPNVPVWDIGGFTLLDGKLVLLGGEEEGPRRPRVGSASSEGSIHVAMGNFRDPDRMPGKTEPETAGPNQVHNVRGLLKRLKEKKKARLEPRDGPPSALGSRESLATLSELDLGAERDVRIWPLHPSLLGEPHCFQVTWTGGSRCFSCRSAAERDRWIEDLRRQFQPTQDNVEREETWLSVWVHEAKGLPRAAAGAPGVRAELWLDGALLARTAPRAGPGQLFWAERFHFEALPPARRLSLRLRGLGPGSAVLGRVALALEELDAPRAPAAGLERWFPLLGAPAGAALRARIRARRLRVLPSERYKELAEFLTFHYARLCGALEPALPAQAKEELAAAMVRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLGQVVRRLCASTEDCEVDPSKCPASELPEHQARLRNSCEEVFETIIHSYDWFPAELGIVFSSWREACKERGSEVLGPRLVCASLFLRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQNLANRAPFGEKEAYMGFMNSFLEEHGPAMQCFLDQVAMVDVDAAPSGYQGSGDLALQLAVLHAQLCTIFAELDQTTRDTLEPLPTILRAIEEGQPVLVSVPMRLPLPPAQVHSSLSAGEKPGFLAPRDLPKHTPLISKSQSLRSVRRSESWARPRPDEERPLRRPRPVQRTQSVPVRRPARRRQSAGPWPRPKGSLSMGPAPRARPWTRDSASLPRKPSVPWQRQMDQPQDRNQALGTHRPVNKLAELQCEVAALREEQKVLSRLVESLSTQIRALTEQQEQLRGQLQDLDSRLRAGSSEFDSEHNLTSNEGHSLKNLEHRLNEMERTQAQLRDAVQSLQLSPRTRGSWSQPQPLKAPCLNGDTT"},{"id":"SEQ_00860","a":"P67809","g":"YBX1","d":"Y-box-binding protein 1","L":324,"m":[{"c":"[RY][RPN][YPF][PRN][RFY]RR[GFR][PR]P","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed basic-aromatic-proline motifs in the C-terminal disordered domain anchored by an invariant central RR dipeptide and C-terminal P (mostly [GF]PP), alternating with 30-45 aa acidic/polar linkers.","i":[[146,155,"RRYPRRRGPP"],[186,195,"RPYRRRRFPP"],[241,250,"YRPRFRRGPP"],[283,292,"RNFNYRRRRP"]]}],"s":"MSSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGSESAPEGQAQQRRPYRRRRFPPYYMRRPYGRRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNMYRGYRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKAADPPAENSSAPEAEQGGAE"},{"id":"SEQ_00863","a":"P11161","g":"EGR2","d":"E3 SUMO-protein ligase EGR2","L":476,"m":[{"c":"[VT][GH][EH]+P[YF]xC(x){2,4}CxR[RNK]F[SA]RSD[EH][LR][TK][RT]H[IT]+[IT]H","u":"28-30","sp":"tandem","x":"structured_like","cf":"high","why":"Three head-to-tail tandem 28-30 aa C2H2-type repeats anchored by invariant P, C(x){2,4}C, R, F, RSD, and HxxxH coordination/recognition positions.","i":[[335,364,"VHERPYPCPAEGCDRRFSRSDELTRHIRIH"],[365,392,"TGHKPFQCRICMRNFSRSDHLTTHIRTH"],[393,420,"TGEKPFACDYCGRKFARSDERKRHTKIH"]]}],"s":"MMTAKAVDKIPVTLSGFVHQLSDNIYPVEDLAATSVTIFPNAELGGPFDQMNGVAGDGMINIDMTGEKRSLDLPYPSSFAPVSAPRNQTFTYMGKFSIDPQYPGASCYPEGIINIVSAGILQGVTSPASTTASSSVTSASPNPLATGPLGVCTMSQTQPDLDHLYSPPPPPPPYSGCAGDLYQDPSAFLSAATTSTSSSLAYPPPPSYPSPKPATDPGLFPMIPDYPGFFPSQCQRDLHGTAGPDRKPFPCPLDTLRVPPPLTPLSTIRNFTLGGPSAGVTGPGASGGSEGPRLPGSSSAAAAAAAAAAYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPSASVPAPSTASCSGGVQPGGTLCSSNSSSLGGGPLAPCSSRTRTP"},{"id":"SEQ_00872","a":"Q86WN1","g":"FCHSD1","d":"F-BAR and double SH3 domains protein 1","L":690,"m":[{"c":"AxφψΩxYo[AG]xxx-EL[ST]φxEGxφψxψψ(x){5,8}DxΩφ+(x){4,5}GxVGφφPxxφψ","u":"52-54","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of a 52-54 aa structured beta-rich domain separated by a 26 aa linker, anchored by conserved A, Y, E, L, G, D, V, and P positions alongside hydrophobic/aromatic core registers (φψΩxYo, -EL[ST]φxEGxφψxψψ, DxΩφ+, and GxVGφφPxxφψ).","i":[[473,524,"AHVVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYL"],[551,604,"AQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFGGRVGVFPSLLV"]]}],"s":"MQPPPRKVKPAQEVKLRFLEQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQALQKLAGPFLKREGHRSGEMDSRGRTVFGAWRCLLDATVAGGQTRLQASDRYRDLAGGTGRSAKEQVLRKGTENLQRAQAEVLQSVRELSRSRKLYGQRERVWALAQEKAADVQARLNRSDHGIFHSRTSLQKLSTKLSAQSAQYSQQLQAARNEYLLNLVATNAHLDHYYQEELPALLKALVSELSEHLRDPLTSLSHTELEAAEVILEHAHRGEQTTSQVSWEQDLKLFLQEPGVFSPTPPQQFQPAGTDQVCVLEWGAEGVAGKSGLEKEVQRLTSRAARDYKIQNHGHRVLQRLEQRRQQASEREAPSIEQRLQEVRESIRRAQVSQVKGAARLALLQGAGLDVERWLKPAMTQAQDEVEQERRLSEARLSQRDLSPTAEDAELSDFEECEETGELFEEPAPQALATRALPCPAHVVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLPESSQDSDNPCGAEPTAFLAQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFGGRVGVFPSLLVEELLGPPGPPELSDPEQMLPSPSPPSFSPPAPTSVLDGPPAPVLPGDKALDFPGFLDMMAPRLRPMRPPPPPPAKAPDPGHPDPLT"},{"id":"SEQ_00874","a":"Q7Z591","g":"AKNA","d":"Microtubule organization protein AKNA","L":1439,"m":[{"c":"PP[AG]φφYφ[AS][STP][AV][PG]","u":11,"sp":"periodic","x":"disordered_like","cf":"medium","why":"Three periodic 11-aa repeats separated by uniform 4-aa linkers (15-aa repeat period) within the C-terminal proline-rich disordered region, defined by an N-terminal PP dipeptide, an invariant central Y flanked by strictly hydrophobic residues (φφYφ), and small flanking positions.","i":[[1322,1332,"PPGLWYLATAP"],[1337,1347,"PPAFAYISSVP"],[1352,1362,"PPAAVYYAPAG"]]}],"s":"MASSETEIRWAEPGLGKGPQRRRWAWAEDKRDVDRSSSQSWEEERLFPNATSPELLEDFRLAQQHLPPLEWDPHPQPDGHQDSESGETSGEEAEAEDVDSPASSHEPLAWLPQQGRQLDMTEEEPDGTLGSLEVEEAGESSSRLGYEAGLSLEGHGNTSPMALGHGQARGWVASGEQASGDKLSEHSEVNPSVELSPARSWSSGTVSLDHPSDSLDSTWEGETDGPQPTALAETLPEGPSHHLLSPDGRTGGSVARATPMEFQDSSAPPAQSPQHATDRWRRETTRFFCPQPKEHIWKQTKTSPKPLPSRFIGSISPLNPQPRPTRQGRPLPRQGATLAGRSSSNAPKYGRGQLNYPLPDFSKVGPRVRFPKDESYRPPKSRSHNRKPQAPARPLIFKSPAEIVQEVLLSSGEAALAKDTPPAHPITRVPQEFQTPEQATELVHQLQEDYHRLLTKYAEAENTIDQLRLGAKVNLFSDPPQPNHSIHTGMVPQGTKVLSFTIPQPRSAEWWPGPAEDPQASAASGWPSARGDLSPSSLTSMPTLGWLPENRDISEDQSSAEQTQALASQASQFLAKVESFERLIQAGRLMPQDQVKGFQRLKAAHAALEEEYLKACREQHPAQPLAGSKGTPGRFDPRRELEAEIYRLGSCLEELKEHIDQTQQEPEPPGSDSALDSTPALPCLHQPTHLPAPSGQAPMPAIKTSCPEPATTTAAASTGPCPLHVNVEVSSGNSEVEDRPQDPLARLRHKELQMEQVYHGLMERYLSVKSLPEAMRMEEEEEGEEEEEEEGGGDSLEVDGVAATPGKAEATRVLPRQCPVQAEKSHGAPLEEATEKMVSMKPPGFQASLARDGHMSGLGKAEAAPPGPGVPPHPPGTKSAASHQSSMTSLEGSGISERLPQKPLHRGGGPHLEETWMASPETDSGFVGSETSRVSPLTQTPEHRLSHISTAGTLAQPFAASVPRDGASYPKARGSLIPRRATEPSTPRSQAQRYLSSPSGPLRQRAPNFSLERTLAAEMAVPGSEFEGHKRISEQPLPNKTISPPPAPAPAAAPLPCGPTETIPSFLLTRAGRDQAICELQEEVSRLRLRLEDSLHQPLQGSPTRPASAFDRPARTRGRPADSPATWGSHYGSKSTERLPGEPRGEEQIVPPGRQRARSSSVPREVLRLSLSSESELPSLPLFSEKSKTTKDSPQAARDGKRGVGSAGWPDRVTFRGQYTGHEYHVLSPKAVPKGNGTVSCPHCRPIRTQDAGGAVTGDPLGPPPADTLQCPLCGQVGSPPEADGPGSATSGAEKATTRRKASSTPSPKQRSKQAGSSPRPPPGLWYLATAPPAPAPPAFAYISSVPIMPYPPAAVYYAPAGPTSAQPAAKWPPTASPPPARRHRHSIQLDLGDLEELNKALSRAVQAAESVRSTTRQMRSSLSADLRQAHSLRGSCLF"},{"id":"SEQ_00881","a":"Q9NY74","g":"ETAA1","d":"Ewing's tumor-associated antigen 1","L":926,"m":[{"c":"LTQQQDIRKDSKTSESICEINNNSEHGAK","u":29,"sp":"tandem","x":"disordered_like","cf":"high","why":"Exact 29-residue head-to-tail tandem duplication (100% sequence identity across all 29 positions) embedded within a polar/charged disordered-like region.","i":[[620,648,"LTQQQDIRKDSKTSESICEINNNSEHGAK"],[649,677,"LTQQQDIRKDSKTSESICEINNNSEHGAK"]]}],"s":"MSRRRKHDDSPSPKKTPHKTVAAEECGSVVEPGRRRLRSARGSWPCGAREGPPGPVRQREQPPTAALCSKSNPEERYETPKRALKMDSLSSSFSSPNDPDGQNDIFWDQNSPLTKQLGKGRKKQIYTTDSDEISHIVNRIAPQDEKPTTNSMLDMWIGETAIPCTPSVAKGKSRAKISCTKLKTQSQEEELMKLAKQFDKNMEELDVIQEQNKRNYDFTQMISETEILSNYKDNIQMWSLHNIVPEIDNATKKPIKGNTKISVANNQNSSQKPFDQIAEAAFNAIFDGSTQKCSGQLSQELPEAFWSTSNTTFVKTNALKEEKIITNETLVIEKLSNKTPRSLSSQVDTPIMTKSCVTSCTKEPETSNKYIDAFTTSDFEDDWENLLGSEPFAMQNIDMPELFPSKTAHVTDQKEICTFNSKTVKNTSRANTSPDARLGDSKVLQDLSSKTYDRELIDAEYRFSPNSNKSNKLSTGNKMKFENSSNKIVIQDEIQNCIVTSNLTKIKEDILTNSTEASERKSALNTRYSNEQKNKCILNQSIKAPVNTDLFGSANLGSKTSVSNPNQTSASKVGSFFDDWNDPSFANEIIKACHQLDNTWEADDVDDDLLYQACDDIERLTQQQDIRKDSKTSESICEINNNSEHGAKLTQQQDIRKDSKTSESICEINNNSEHGAKNMFAISKQGSNLVQSKHLNPGSISVQTSLTNSSQIDKPMKMEKGEMYGNSPRFLGATNLTMYSKISNCQINNLHVSYTNTDVPIQVNSSKLVLPGSSSLNVTSDHMNTEITTYKKKLSTNQPCHKTVTDEAQSNLNTTVGFSKFTFTRMKNSQILSQFNQNCITGSMSDTKITQGVEKKKGVNPLLEEAVGQQSLVKLSESLKQSSKEEEEKNRKCSPEEIQRKRQEALVRRMAKARASSVNAAPTSFL"},{"id":"SEQ_00882","a":"Q96EV2","g":"RBM33","d":"RNA-binding protein 33","L":1170,"m":[{"c":"[QR]PF[IL]P","u":5,"sp":"periodic","x":"disordered_like","cf":"medium","why":"Three closely spaced copies separated by 2-3 aa linkers (PR and GPG) in the central proline/glutamine-rich disordered region, anchored by invariant P-F and C-terminal P flanking a conserved aliphatic [IL] position (distinct from adjacent unanchored P/Q/H low-complexity tracts).","i":[[552,556,"RPFIP"],[559,563,"QPFLP"],[567,571,"QPFLP"]]}],"s":"MAAALGASGGAGAGDDDFDQFDKPGAERSWRRRAADEDWDSELEDDLLGEDLLSGKKNQSDLSDEELNDDLLQSDNEDEENFSSQGVTISLNATSGMVTSFELSDNTNDQSGEQESEYEQEQGEDELVYHKSDGSELYTQEYPEEGQYEGHEAELTEDQIEYVEEPEEEQLYTDEVLDIEINEPLDEFTGGMETLELQKDIKEESDEEEEDDEESGRLRFKTERKEGTIIRLSDVTRERRNIPETLELSAEAKAALLEFEERERQHKQGRYSSRRGGRRGGPLMCRGVGDQRRESTERGRMKDHRPALLPTQPPVVPQAPPPPPPPPQQQPIRSLFQPQPLQPLLPVQHPHHPSPPQGMHMPPQLETPRMMMTPPPVTPQQPKNIHINPHFKGTVVTPVQVPLLPVPSQPRPAVGPQRFPGPPEFPQHTPGPVPNSFSQPPRLPLQDQWRAPPPPQDRDPFFLGVSGEPRFPSHLFLEQRSPPPPPPPPTLLNSSHPVPTQSPLPFTQPGPAFNQQGQQPVFPRERPVRPALQPPGPVGILHFSQPGSATTRPFIPPRQPFLPGPGQPFLPTHTQPNLQGPLHPPLPPPHQPQPQQPQQQPPPQHQPPHQPPHQPPPQHQPPPQHPPQHPPQHQHHHHHHHLSVPPPPLMPMSQPQFRPHVQTAQPQASSSRMQCPQRQGLRHNTTSQNVSKRPMQQMQPTAPRNSNLRELPIAPSHVIEMSSSRCSATPSAQVKPIVSASPPSRAVAGSRSSQGKTEVKVKPASPVAQPKEEAKTETEFPDEDEETRLYRLKIEEQKRLREEILKQKELRRQQQAGARKKELLERLAQQQQQLYAPPPPAEQEEQALSPSPTNGNPLLPFPGAQVRQNVKNRLLVKNQDVSISNVQPKTSNFVPSSANMQYQGQQMKALKHLRQTRTVPQSQTQPLHKVLPIKPADVEEPAVPQTPRVASIQGRPQDTKPGVKRTVTHRTNSGGGDGPHISSKVRVIKLSGGGGESDGFFHPEGQPQRLPQPPEVGPQPARKVTLTRGGLQQPPHLPAGPHAHSPVPPGIKSIQGIHPAKKAIMHGRGRGVAGPMGRGRLMPNKQNLRVVECKPQPCVVSVEGLSSSTTDAQLKSLLMSVGPIQSLQMLPQQRKAIAKFKEPAHALAFQQKFHRHMIDLSHINVALIVE"},{"id":"SEQ_00884","a":"O94913","g":"PCF11","d":"Pre-mRNA cleavage complex 2 protein Pcf11","L":1555,"m":[{"c":"xR[FI]-[GNR]xxx","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"25-copy repeat array in a Gly/Pro/Gln-rich disordered region anchored by an invariant R, conserved [FI]-acidic-Gly core ( predominantly [LIM]RF[DE]GPxG), and separated by 0-7 aa Gly/Pro/Gln linkers (including an 11-copy central block with regular 5-aa QPVGG/QPGGG linkers).","i":[[789,796,"LRFDGSPG"],[804,811,"LRFEGPQG"],[819,826,"LRFEGPPG"],[832,839,"LRFEGPIG"],[846,853,"FRFEGSPG"],[854,861,"LRFEGSPG"],[863,870,"LRFEGPGG"],[876,883,"LRFEGHRG"],[889,896,"LRFEGPHG"],[902,909,"LRFDNPRG"],[915,922,"LRFEGGHG"],[928,935,"IRFDGPHG"],[941,948,"IRFEGPLL"],[954,961,"MRFEGPHG"],[967,974,"LRFEGQHN"],[980,987,"LRFEGPHG"],[993,1000,"IRFEGPLV"],[1006,1013,"MRFEGPSV"],[1018,1025,"LRIEGPLG"],[1029,1036,"PRFEGCHA"],[1037,1044,"LRFDGQPG"],[1050,1057,"PRFDGLHG"],[1061,1068,"PRFERTPG"],[1073,1080,"QRFDGPPG"],[1092,1099,"QRFDGPQH"]]},{"c":"RDPR[LR][NKM]+","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed copies in the N-terminal disordered region sharing an invariant RDPR tetrapeptide core followed by [LR], a polar/aliphatic position, and a conserved C-terminal basic residue.","i":[[295,301,"RDPRLNR"],[400,406,"RDPRLKK"],[553,559,"RDPRRMK"]]}],"s":"MSEQTPAEAGAAGAREDACRDYQSSLEDLTFNSKPHINMLTILAEENLPFAKEIVSLIEAQTAKAPSSEKLPVMYLMDSIVKNVGREYLTAFTKNLVATFICVFEKVDENTRKSLFKLRSTWDEIFPLKKLYALDVRVNSLDPAWPIKPLPPNVNTSSIHVNPKFLNKSPEEPSTPGTVVSSPSISTPPIVPDIQKNLTQEQLIRQQLLAKQKQLLELQQKKLELELEQAKAQLAVSLSVQQETSNLGPGSAPSKLHVSQIPPMAVKAPHQVPVQSEKSRPGPSLQIQDLKGTNRDPRLNRISQHSHGKDQSHRKEFLMNTLNQSDTKTSKTIPSEKLNSSKQEKSKSGEKITKKELDQLDSKSKSKSKSPSPLKNKLSHTKDLKNQESESMRLSDMNKRDPRLKKHLQDKTDGKDDDVKEKRKTAEKKDKDEHMKSSEHRLAGSRNKIINGIVQKQDTITEESEKQGTKPGRSSTRKRSRSRSPKSRSPIIHSPKRRDRRSPKRRQRSMSPTSTPKAGKIRQSGAKQSHMEEFTPPSREDRNAKRSTKQDIRDPRRMKKTEEERPQETTNQHSTKSGTEPKENVENWQSSKSAKRWKSGWEENKSLQQVDEHSKPPHLRHRESWSSTKGILSPRAPKQQQHRLSVDANLQIPKELTLASKRELLQKTSERLASGEITQDDFLVVVHQIRQLFQYQEGVREEQRSPFNDRFPLKRPRYEDSDKPFVDSPASRFAGLDTNQRLTALAEDRPLFDGPSRPSVARDGPTKMIFEGPNKLSPRIDGPPTPASLRFDGSPGQMGGGGPLRFEGPQGQLGGGCPLRFEGPPGPVGTPLRFEGPIGQAGGGGFRFEGSPGLRFEGSPGGLRFEGPGGQPVGGLRFEGHRGQPVGGLRFEGPHGQPVGGLRFDNPRGQPVGGLRFEGGHGPSGAAIRFDGPHGQPGGGIRFEGPLLQQGVGMRFEGPHGQSVAGLRFEGQHNQLGGNLRFEGPHGQPGVGIRFEGPLVQQGGGMRFEGPSVPGGGLRIEGPLGQGGPRFEGCHALRFDGQPGQPSLLPRFDGLHGQPGPRFERTPGQPGPQRFDGPPGQQVQPRFDGVPQRFDGPQHQQASRFDIPLGLQGTRFDNHPSQRLESVSFNQTGPYNDPPGNAFNAPSQGLQFQRHEQIFDSPQGPNFNGPHGPGNQSFSNPLNRASGHYFDEKNLQSSQFGNFGNIPAPMTVGNIQASQQVLSGVAQPVAFGQGQQFLPVHPQNPGFVQNPSGALPKAYPDNHLSQVDVNELFSKLLKTGILKLSQTDSATTQVSEVTAQPPPEEEEDQNEDQDVPDLTNFTVEELKQRYDSVINRLYTGIQCYSCGMRFTTSQTDVYADHLDWHYRQNRTEKDVSRKVTHRRWYYSLTDWIEFEEIADLEERAKSQFFEKVHEEVVLKTQEAAKEKEFQSVPAGPAGAVESCEICQEQFEQYWDEEEEEWHLKNAIRVDGKIYHPSCYEDYQNTSSFDCTPSPSKTPVENPLNIMLNIVKNELQEPCDSPKVKEERIDTPPACTEESIATPSEIKTENDTVESV"},{"id":"SEQ_00896","a":"Q92804","g":"TAF15","d":"TATA-binding protein-associated factor 2N","L":592,"m":[{"c":"[GS]GY[GS]GDR","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Extensive 19-copy C-terminal disordered tandem array (17 identical GGYGGDR units plus 2 conservative G/S variants) anchored by invariant Y and DR residues separated by 0-3 aa Gly/Ser/Arg linkers.","i":[[416,422,"GGYGGDR"],[425,431,"GGYGGDR"],[435,441,"GGYSGDR"],[444,450,"GGYGGDR"],[453,459,"GGYGGDR"],[461,467,"GGYGGDR"],[469,475,"GGYGGDR"],[477,483,"GGYGGDR"],[484,490,"GGYGGDR"],[492,498,"GGYGGDR"],[499,505,"GGYGGDR"],[506,512,"GGYGGDR"],[513,519,"GGYGGDR"],[520,526,"GGYGGDR"],[529,535,"GGYGGDR"],[539,545,"SGYGGDR"],[547,553,"GGYGGDR"],[556,562,"GGYGGDR"],[564,570,"GGYGGDR"]]},{"c":"[GS][GS]Y[GS]Qo","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Six non-overlapping copies in the N-terminal polar/Gly-rich disordered region sharing invariant Tyr and Gln anchors flanked by Gly/Ser and C-terminal polar uncharged residues.","i":[[5,10,"GSYGQS"],[36,41,"SGYGQT"],[44,49,"SSYGQN"],[54,59,"SSYGQS"],[61,66,"SGYSQS"],[76,81,"SSYSQQ"]]},{"c":"[SGN]YD[QE][QHP]x","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five clustered copies in the central N-terminal disordered segment (four near-tandem with 0-1 aa gaps plus one N-terminal copy across a 5-aa linker) anchored by an invariant YD dipeptide followed by Gln/Glu and Gln/His/Pro.","i":[[104,109,"SYDQPD"],[115,120,"SYDQQS"],[121,126,"GYDQHQ"],[128,133,"SYDEQS"],[134,139,"NYDQQH"]]}],"s":"MSDSGSYGQSGGEQQSYSTYGNPGSQGYGQASQSYSGYGQTTDSSYGQNYSGYSSYGQSQSGYSQSYGGYENQKQSSYSQQPYNNQGQQQNMESSGSQGGRAPSYDQPDYGQQDSYDQQSGYDQHQGSYDEQSNYDQQHDSYSQNQQSYHSQRENYSHHTQDDRRDVSRYGEDNRGYGGSQGGGRGRGGYDKDGRGPMTGSSGGDRGGFKNFGGHRDYGPRTDADSESDNSDNNTIFVQGLGEGVSTDQVGEFFKQIGIIKTNKKTGKPMINLYTDKDTGKPKGEATVSFDDPPSAKAAIDWFDGKEFHGNIIKVSFATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRSGGGYGGDRSSGGGYSGDRSGGGYGGDRSGGGYGGDRGGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRSRGGYGGDRGGGSGYGGDRSGGYGGDRSGGGYGGDRGGGYGGDRGGYGGKMGGRNDYRNDQRNRPY"},{"id":"SEQ_00904","a":"P52756","g":"RBM5","d":"RNA-binding protein 5","L":815,"m":[{"c":"TI[MI]LRxψxxxxxxxxIxxφψxxΩxxxxxxxψRLψKxK(x){4,5}RGFAFVxφxxφxDA[TS](x){9,12}LxIxGKxI[AG]ψxΩ[SA]","u":"78-82","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of a 78-82 aa globular domain separated by a 55 aa linker, strongly anchored by N-terminal TI[MI]LR, central ψRLψKxK and invariant RGFAFV, DA[TS], and C-terminal LxIxGKxI[AG]ψxΩ[SA] motifs.","i":[[99,176,"TIMLRGLPITITESDIREMMESFEGPQPADVRLMKRKTGVSRGFAFVEFYHLQDATSWMEANQKKLVIQGKHIAMHYS"],[232,313,"TIILRNIAPHTVVDSIMTALSPYASLAVNNIRLIKDKQTQQNRGFAFVQLSSAMDASQLLQILQSLHPPLKIDGKTIGVDFA"]]},{"c":"D[EP]o[ST][GQ][YL]YY","u":8,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three head-to-tail tandem 8-mer repeats in the central polar/tyrosine-rich disordered region, conserved across all eight positions with invariant N-terminal D and C-terminal [YL]YY anchors.","i":[[465,472,"DESSGYYY"],[473,480,"DPTTGLYY"],[481,488,"DPNSQYYY"]]}],"s":"MGSDKRVSRTERSGRYGSIIDRDDRDERESRSRRRDSDYKRSSDDRRGDRYDDYRDYDSPERERERRNSDRSEDGYHSDGDYGEHDYRHDISDERESKTIMLRGLPITITESDIREMMESFEGPQPADVRLMKRKTGVSRGFAFVEFYHLQDATSWMEANQKKLVIQGKHIAMHYSNPRPKFEDWLCNKCCLNNFRKRLKCFRCGADKFDSEQEVPPGTTESVQSVDYYCDTIILRNIAPHTVVDSIMTALSPYASLAVNNIRLIKDKQTQQNRGFAFVQLSSAMDASQLLQILQSLHPPLKIDGKTIGVDFAKSARKDLVLSDGNRVSAFSVASTAIAAAQWSSTQSQSGEGGSVDYSYLQPGQDGYAQYAQYSQDYQQFYQQQAGGLESDASSASGTAVTTTSAAVVSQSPQLYNQTSNPPGSPTEEAQPSTSTSTQAPAASPTGVVPGTKYAVPDTSTYQYDESSGYYYDPTTGLYYDPNSQYYYNSLTQQYLYWDGEKETYVPAAESSSHQQSGLPPAKEGKEKKEKPKSKTAQQIAKDMERWAKSLNKQKENFKNSFQPVNSLREEERRESAAADAGFALFEKKGALAERQQLIPELVRNGDEENPLKRGLVAAYSGDSDNEEELVERLESEEEKLADWKKMACLLCRRQFPNKDALVRHQQLSDLHKQNMDIYRRSRLSEQELEALELREREMKYRDRAAERREKYGIPEPPEPKRKKQFDAGTVNYEQPTKDGIDHSNIGNKMLQAMGWREGSGLGRKCQGITAPIEAQVRLKGAGLGAKGSAYGLSGADSYKDAVRKAMFARFTEME"},{"id":"SEQ_00905","a":"Q8N554","g":"ZNF276","d":"Zinc finger protein 276","L":614,"m":[{"c":"C(x){2,4}C[GNT]xxxxxxxx[LM]xxH(x){3,4}H","u":"21-24","sp":"periodic","x":"structured_like","cf":"high","why":"Five C-terminal C2H2-type repeats of 21-24 aa separated by regular 7-9 aa linkers, defined by invariant C(x){2,4}C and H(x){3,4}H pairs plus a conserved aliphatic [LM] anchor three residues before the first histidine.","i":[[436,459,"CPYQGCTAVYRGADGMKKHIKEHH"],[467,490,"CPHPGCNKVFMIDRYLQRHVKLIH"],[498,518,"CDECGQTFKQRKHLLVHQMRH"],[526,546,"CEVCGFQCRQRASLKYHMTKH"],[556,577,"CDQCGRRFEKAHNLNVHMSMVH"]]}],"s":"MKRDRLGRFLSPGSSRQCGASDGGGGVSRTRGRPSLSGGPRVDGATARRAWGPVGSCGDAGEDGADEAGAGRALAMGHCRLCHGKFSSRSLRSISERAPGASMERPSAEERVLVRDFQRLLGVAVRQDPTLSPFVCKSCHAQFYQCHSLLKSFLQRVNASPAGRRKPCAKVGAQPPTGAEEGACLVDLITSSPQCLHGLVGWVHGHAASCGALPHLQRTLSSEYCGVIQVVWGCDQGHDYTMDTSSSCKAFLLDSALAVKWPWDKETAPRLPQHRGWNPGDAPQTSQGRGTGTPVGAETKTLPSTDVAQPPSDSDAVGPRSGFPPQPSLPLCRAPGQLGEKQLPSSTSDDRVKDEFSDLSEGDVLSEDENDKKQNAQSSDESFEPYPERKVSGKKSESKEAKKSEEPRIRKKPGPKPGWKKKLRCEREELPTIYKCPYQGCTAVYRGADGMKKHIKEHHEEVRERPCPHPGCNKVFMIDRYLQRHVKLIHTEVRNYICDECGQTFKQRKHLLVHQMRHSGAKPLQCEVCGFQCRQRASLKYHMTKHKAETELDFACDQCGRRFEKAHNLNVHMSMVHPLTQTQDKALPLEAEPPPGPPSPSVTTEGQAVKPEPT"},{"id":"SEQ_00910","a":"Q6ZV73","g":"FGD6","d":"FYVE, RhoGEF and PH domain-containing protein 6","L":1430,"m":[{"c":"P[PA][IV]APKP[KD]φ[VL]","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three well-conserved 10-aa repeats in the N-terminal disordered tail (separated by 8-aa and 12-aa linkers) anchored by an invariant PxxAPKP core and a C-terminal hydrophobic-aliphatic (φ[VL]) dyad.","i":[[10,19,"PPVAPKPKFV"],[28,37,"PPIAPKPDIV"],[50,59,"PAIAPKPKVL"]]}],"s":"MTSAAEIKKPPVAPKPKFVVANNKPAPPPIAPKPDIVISSVPQSTKKMKPAIAPKPKVLKTSPVREIGQSPSRKIMLNLEGHKQELAESTDNFNCKYEGNQSNDYISPMCSCSSECIHKLGHRENLCVKQLVLEPLEMNENLENSKIDETLTIKTRSKCDLYGEKAKNQGGVVLKASVLEEELKDALIHQMPPFISAQKHRPTDSPEMNGGCNSNGQFRIEFADLSPSPSSFEKVPDHHSCHLQLPSDECEHFETCQDDSEKSNNCFQSSELEALENGKRSTLISSDGVSKKSEVKDLGPLEIHLVPYTPKFPTPKPRKTRTARLLRQKCVDTPSESTEEPGNSDSSSSCLTENSLKINKISVLHQNVLCKQEQVDKMKLGNKSELNMESNSDAQDLVNSQKAMCNETTSFEKMAPSFDKDSNLSSDSTTVDGSSMSLAVDEGTGFIRCTVSMSLPKQLKLTCNEHLQSGRNLGVSAPQMQKESVIKEENSLRIVPKKPQRHSLPATGVLKKAASEELLEKSSYPSSEEKSSEKSLERNHLQHLCAQNRGVSSSFDMPKRASEKPVWKLPHPILPFSGNPEFLKSVTVSSNSEPSTALTKPRAKSLSAMDVEKCTKPCKDSTKKNSFKKLLSMKLSICFMKSDFQKFWSKSSQLGDTTTGHLSSGEQKGIESDWQGLLVGEEKRSKPIKAYSTENYSLESQKKRKKSRGQTSAANGLRAESLDDQMLSRESSSQAPYKSVTSLCAPEYENIRHYEEIPEYENLPFIMAIRKTQELEWQNSSSMEDADANVYEVEEPYEAPDGQLQLGPRHQHSSSGASQEEQNDLGLGDLPSDEEEIINSSDEDDVSSESSKGEPDPLEDKQDEDNGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYYLPQLYELNRDLLKELEERMLHWTEQQRIADIFVKKGPYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGHHEIVQPGRVFLKEGILMKLSRKVMQPRMFFLFNDALLYTTPVQSGMYKLNNMLSLAGMKVRKPTQEAYQNELKIESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDEADSENKEEVSPLGSKAPIWIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKYGLDYLKNQPARVCEHCFQELQKLDHQHSPRIGSPGNHKSPSSALSSVLHSIPSGRKQKKIPAALKEVSANTEDSSMSGYLYRSKGNKKPWKHFWFVIKNKVLYTYAASEDVAALESQPLLGFTVIQVKDENSESKVFQLLHKNMLFYVFKAEDAHSAQKWIEAFQEGTIL"},{"id":"SEQ_00927","a":"Q9P212","g":"PLCE1","d":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1","L":2302,"m":[{"c":"VoVHxVx[GP]xxPxTVφxφxxx[ST]xAxxψψQQxLx(x){10,15}DYφLψEExφxx[ST]xxKxxxxxxxxQRφψxxxExψφQφxSxW","u":"82-87","sp":"dispersed","x":"structured_like","cf":"high","why":"C-terminal pair of homologous 82-87 aa globular domain repeats separated by a 41-aa linker, sharing two gapless core blocks (32 aa and 40 aa) with 22 identical anchor residues (including VoVH, PxTV, AxxψψQQxL, DYφLψEE, QRφψ, and C-terminal QφxSxW) and conserved hydrophobic core positions.","i":[[2016,2097,"VTVHGVPGPEPFTVFTINGGTKAKQLLQQILTNEQDIKPVTTDYFLMEEKYFISKEKNECRKQPFQRAIGPEEEIMQILSSW"],[2139,2225,"VQVHDVSPEQPRTVIKAPRVSTAQDVIQQTLCKAKYSYSILSNPNPSDYVLLEEVVKDTTNKKTTTPKSSQRVLLDQECVFQAQSKW"]]}],"s":"MTSEEMTASVLIPVTQRKVVSAQSAADESSEKVSDINISKAHTVRRSGETSHTISQLNKLKEEPSGSNLPKILSIAREKIVSDENSNEKCWEKIMPDSAKNLNINCNNILRNHQHGLPQRQFYEMYNSVAEEDLCLETGIPSPLERKVFPGIQLELDRPSMGISPLGNQSVIIETGRAHPDSRRAVFHFHYEVDRRMSDTFCTLSENLILDDCGNCVPLPGGEEKQKKNYVAYTCKLMELAKNCDNKNEQLQCDHCDTLNDKYFCFEGSCEKVDMVYSGDSFCRKDFTDSQAAKTFLSHFEDFPDNCDDVEEDAFKSKKERSTLLVRRFCKNDREVKKSVYTGTRAIVRTLPSGHIGLTAWSYIDQKRNGPLLPCGRVMEPPSTVEIRQDGSQRLSEAQWYPIYNAVRREETENTVGSLLHFLTKLPASETAHGRISVGPCLKQCVRDTVCEYRATLQRTSISQYITGSLLEATTSLGARSGLLSTFGGSTGRMMLKERQPGPSVANSNALPSSSAGISKELIDLQPLIQFPEEVASILMEQEQTIYRRVLPVDYLCFLTRDLGTPECQSSLPCLKASISASILTTQNGEHNALEDLVMRFNEVSSWVTWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSRKVLKMWQFMDQSDIETMRSLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKELCEVLDGASGLMKLCPRYNSQEETLEFVADYSGQDNFLQRVGQNGLKNSEKESTVNSIFQVIRSCNRSLETDEEDSPSEGNSSRKSSLKDKSRWQFIIGDLLDSDNDIFEQSKEYDSHGSEDSQKAFDHGTELIPWYVLSIQADVHQFLLQGATVIHYDQDTHLSARCFLQLQPDNSTLTWVKPTTASPASSKAKLGVLNNTAEPGKFPLLGNAGLSSLTEGVLDLFAVKAVYMGHPGIDIHTVCVQNKLGSMFLSETGVTLLYGLQTTDNRLLHFVAPKHTAKMLFSGLLELTRAVRKMRKFPDQRQQWLRKQYVSLYQEDGRYEGPTLAHAVELFGGRRWSARNPSPGTSAKNAEKPNMQRNNTLGISTTKKKKKILMRGESGEVTDDEMATRKAKMHKECRSRSGSDPQDINEQEESEVNAIANPPNPLPSRRAHSLTTAGSPNLAAGTSSPIRPVSSPVLSSSNKSPSSAWSSSSWHGRIKGGMKGFQSFMVSDSNMSFVEFVELFKSFSVRSRKDLKDLFDVYAVPCNRSGSESAPLYTNLTIDENTSDLQPDLDLLTRNVSDLGLFIKSKQQLSDNQRQISDAIAAASIVTNGTGIESTSLGIFGVGILQLNDFLVNCQGEHCTYDEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKENFASKNDESQENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTVFGEKLVTKFLFETDFSDDPMLPSPDQLRKKVLLKNKKLKAHQTPVDILKQKAHQLASMQVQAYNGGNANPRPANNEEEEDEEDEYDYDYESLSDDNILEDRPENKSCNDKLQFEYNEEIPKRIKKADNSACNKGKVYDMELGEEFYLDQNKKESRQIAPELSDLVIYCQAVKFPGLSTLNASGSSRGKERKSRKSIFGNNPGRMSPGETASFNKTSGKSSCEGIRQTWEESSSPLNPTTSLSAIIRTPKCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLERDLDSMDPAVYSLTIVSGQNVCPSNSMGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFLFHVHFEDLVFLRFAVVENNSSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLFINSRRMEENSSGNTMSASSMFNTEERKCLQTHRVTVHGVPGPEPFTVFTINGGTKAKQLLQQILTNEQDIKPVTTDYFLMEEKYFISKEKNECRKQPFQRAIGPEEEIMQILSSWFPEEGYMGRIVLKTQQENLEEKNIVQDDKEVILSSEEESFFVQVHDVSPEQPRTVIKAPRVSTAQDVIQQTLCKAKYSYSILSNPNPSDYVLLEEVVKDTTNKKTTTPKSSQRVLLDQECVFQAQSKWKGAGKFILKLKEQVQASREDKKKGISFASELKKLTKSTKQPRGLTSPSQLLTSESIQTKEEKPVGGLSSSDTMDYRQ"},{"id":"SEQ_00964","a":"Q9BXP8","g":"PAPPA2","d":"Pappalysin-2","L":1791,"m":[{"c":"Cxx[PL](x){9,12}C(x){9,10}CxxxC(x){8,30}[IL]xC(x){2,3}[GR]xW(x){4,8}C","u":"52-77","sp":"periodic","x":"structured_like","cf":"high","why":"Five consecutive 52-77 aa cysteine-rich structured domain repeats in the C-terminal region separated by regular 3-6 aa linkers, each anchored by six invariant cysteines (including an exact CxxxC central motif), an N-terminal Cxx[PL] motif, a conserved [IL]xC motif, and a C-terminal [GR]xW tryptophan signature.","i":[[1396,1459,"CPSLLLDHADVVNCTSIGPGLMKCAITCQRGFALQASSGQYIRPMQKEILLTCSSGHWDQNVSC"],[1464,1521,"CGVPDPSLVNYANFSCSEGTKFLKRCSISCVPPAKLQGLSPWLTCLEDGLWSLPEVYC"],[1525,1590,"CDAPPIILNANLLLPHCLQDNHDVGTICKYECKPGYYVAESAEGKVRNKLLKIQCLEGGIWEQGSC"],[1595,1646,"CEPPPPVFEGMYECTNGFSLDSQCVLNCNQEREKLPILCTKEGLWTQEFKLC"],[1653,1729,"CPPPPSELNSVEYKCEQGYGIGAVCSPLCVIPPSDPVMLPENITADTLEHWMEPVKVQSIVCTGRRQWHPDPVLVHC"]]}],"s":"MMCLKILRISLAILAGWALCSANSELGWTRKKSLVEREHLNQVLLEGERCWLGAKVRRPRASPQHHLFGVYPSRAGNYLRPYPVGEQEIHHTGRSKPDTEGNAVSLVPPDLTENPAGLRGAVEEPAAPWVGDSPIGQSELLGDDDAYLGNQRSKESLGEAGIQKGSAMAATTTTAIFTTLNEPKPETQRRGWAKSRQRRQVWKRRAEDGQGDSGISSHFQPWPKHSLKHRVKKSPPEESNQNGGEGSYREAETFNSQVGLPILYFSGRRERLLLRPEVLAEIPREAFTVEAWVKPEGGQNNPAIIAGVFDNCSHTVSDKGWALGIRSGKDKGKRDARFFFSLCTDRVKKATILISHSRYQPGTWTHVAATYDGRHMALYVDGTQVASSLDQSGPLNSPFMASCRSLLLGGDSSEDGHYFRGHLGTLVFWSTALPQSHFQHSSQHSSGEEEATDLVLTASFEPVNTEWVPFRDEKYPRLEVLQGFEPEPEILSPLQPPLCGQTVCDNVELISQYNGYWPLRGEKVIRYQVVNICDDEGLNPIVSEEQIRLQHEALNEAFSRYNISWQLSVHQVHNSTLRHRVVLVNCEPSKIGNDHCDPECEHPLTGYDGGDCRLQGRCYSWNRRDGLCHVECNNMLNDFDDGDCCDPQVADVRKTCFDPDSPKRAYMSVKELKEALQLNSTHFLNIYFASSVREDLAGAATWPWDKDAVTHLGGIVLSPAYYGMPGHTDTMIHEVGHVLGLYHVFKGVSERESCNDPCKETVPSMETGDLCADTAPTPKSELCREPEPTSDTCGFTRFPGAPFTNYMSYTDDNCTDNFTPNQVARMHCYLDLVYQQWTESRKPTPIPIPPMVIGQTNKSLTIHWLPPISGVVYDRASGSLCGACTEDGTFRQYVHTASSRRVCDSSGYWTPEEAVGPPDVDQPCEPSLQAWSPEVHLYHMNMTVPCPTEGCSLELLFQHPVQADTLTLWVTSFFMESSQVLFDTEILLENKESVHLGPLDTFCDIPLTIKLHVDGKVSGVKVYTFDERIEIDAALLTSQPHSPLCSGCRPVRYQVLRDPPFASGLPVVVTHSHRKFTDVEVTPGQMYQYQVLAEAGGELGEASPPLNHIHGAPYCGDGKVSERLGEECDDGDLVSGDGCSKVCELEEGFNCVGEPSLCYMYEGDGICEPFERKTSIVDCGIYTPKGYLDQWATRAYSSHEDKKKCPVSLVTGEPHSLICTSYHPDLPNHRPLTGWFPCVASENETQDDRSEQPEGSLKKEDEVWLKVCFNRPGEARAIFIFLTTDGLVPGEHQQPTVTLYLTDVRGSNHSLGTYGLSCQHNPLIINVTHHQNVLFHHTTSVLLNFSSPRVGISAVALRTSSRIGLSAPSNCISEDEGQNHQGQSCIHRPCGKQDSCPSLLLDHADVVNCTSIGPGLMKCAITCQRGFALQASSGQYIRPMQKEILLTCSSGHWDQNVSCLPVDCGVPDPSLVNYANFSCSEGTKFLKRCSISCVPPAKLQGLSPWLTCLEDGLWSLPEVYCKLECDAPPIILNANLLLPHCLQDNHDVGTICKYECKPGYYVAESAEGKVRNKLLKIQCLEGGIWEQGSCIPVVCEPPPPVFEGMYECTNGFSLDSQCVLNCNQEREKLPILCTKEGLWTQEFKLCENLQGECPPPPSELNSVEYKCEQGYGIGAVCSPLCVIPPSDPVMLPENITADTLEHWMEPVKVQSIVCTGRRQWHPDPVLVHCIQSCEPFQADGWCDTINNRAYCHYDGGDCCSSTLSSKKVIPFAADCDLDECTCRDPKAEENQ"},{"id":"SEQ_00992","a":"A5A3E0","g":"POTEF","d":"POTE ankyrin domain family member F","L":1075,"m":[{"c":"LR[SN]KMGKWC[CR][RH]CFPCCR[EG]S[GS]KS[NK]VG[TA][SW]GD[HY]DDSA[MF][KM][TE]","u":37,"sp":"tandem","x":"structured_like","cf":"high","why":"Three head-to-tail 37-aa tandem repeats near the N-terminus sharing >80% pairwise identity, anchored by invariant LR, KMGKWC, CFPCCR, KS, VG, GD, and DDSA motifs.","i":[[20,56,"LRSKMGKWCCRCFPCCRESGKSNVGTSGDHDDSAMKT"],[57,93,"LRSKMGKWCRHCFPCCRGSGKSNVGASGDHDDSAMKT"],[94,130,"LRNKMGKWCCHCFPCCRGSSKSKVGAWGDYDDSAFME"]]},{"c":"IC[QE]LLSDYKEKQM[LP]K[IY]SSENSNPEQDLKLTSEEESQR[FL]KGSEN[SG]QPEK[MR]SQEPEINKDGDRE[VL]E(x){1,6}EMKKH[ER]S[NT][NH]VG[LF][LP]ENLTNG[VA]TAGNGD[ND]GLIP[QP]RKSRTPE[NS]QQFPD[NT]E[SN]EEYH[RS]","u":"118-123","sp":"tandem","x":"mixed","cf":"high","why":"Head-to-tail 2-copy internal duplication of 118 and 123 aa with >80% sequence identity across the entire unit, differing in length only by a 5-residue insertion in the second copy.","i":[[353,470,"ICQLLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRFKGSENSQPEKMSQEPEINKDGDREVEEEMKKHESNNVGLLENLTNGVTAGNGDNGLIPQRKSRTPENQQFPDNESEEYHR"],[471,593,"ICELLSDYKEKQMPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIEEMKKHRSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHS"]]},{"c":"[DN]xx[GK]xT[ATP]L[HIL]x[AG]xxxxxxxx[AV][KLS]φL[LI]xxxxxx[NS]xx","u":33,"sp":"tandem","x":"structured_like","cf":"high","why":"Five contiguous 33-aa structured tandem repeats defined by a conserved [DN]xx[GK]xT[ATP]L[HIL]x[AG] N-terminal turn-helix signature and a hydrophobic [AV][KLS]φL[LI] second helix.","i":[[170,202,"DKQKRTALHLASANGNSEVVKLLLDRRCQLNVL"],[203,235,"DNKKRTALIKAVQCQEDECALMLLEHGTDPNIP"],[236,268,"DEYGNTTLHYAIYNEDKLMAKALLLYGADIESK"],[269,301,"NKHGLTPLLLGVHEQKQQVVKFLIKKKANLNAL"],[302,334,"DRYGRTALILAVCCGSASIVSLLLEQNIDVSSQ"]]}],"s":"MVVEVDSMPAASSVKKPFGLRSKMGKWCCRCFPCCRESGKSNVGTSGDHDDSAMKTLRSKMGKWCRHCFPCCRGSGKSNVGASGDHDDSAMKTLRNKMGKWCCHCFPCCRGSSKSKVGAWGDYDDSAFMEPRYHVRGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKQDKQKRTALHLASANGNSEVVKLLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRFKGSENSQPEKMSQEPEINKDGDREVEEEMKKHESNNVGLLENLTNGVTAGNGDNGLIPQRKSRTPENQQFPDNESEEYHRICELLSDYKEKQMPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIEEMKKHRSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQKQFCEEQNTGILHDEILIHEEKQIEVVEKMNSELSLSCKKEKDILHENSTLREEIAMLRLELDTMKHQSQLREKKYLEDIESVKKRNDNLLKALQLNELTMDDDTAVLVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRQQGMMGGMHQKESYVGKEAQSKRGILTLKYPMEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEATLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYTSGRTTGIVMDSGDGVTHTVPIYEGNALPHATLRLDLAGRELPDYLMKILTEHGYRFTTMAEREIVRDIKEKLCYVALDFEQEMATVASSSSLEKSYELPDGQVITIGNERFRCPEALFQPCFLGMESCGIHETTFNSIMKSDVDIRKDLYTNTVLSGGTTMYPGMAHRMQKEIAALAPSMMKIRIIAPPKRKYSVWVGGSILASLSTFQQMWISKQEYDESGPSIVHRKCL"},{"id":"SEQ_00999","a":"Q9Y6Y1","g":"CAMTA1","d":"Calmodulin-binding transcription activator 1","L":1673,"m":[{"c":"[AT]Axψ[IV]QxxφR[KS][YS]xxxx[KL]xx[QK]xxx","u":23,"sp":"tandem","x":"structured_like","cf":"high","why":"Five head-to-tail tandem 23-residue helical repeats anchored by a conserved [AT]Axψ[IV]QxxφR core (invariant A2, Q6, R10) and C-terminal basic/polar positions ([KL]17, [QK]20).","i":[[1527,1549,"AARLVQTAFRKYKGRPLREQQEV"],[1550,1572,"AAAVIQRCYRKYKQYALYKKMTQ"],[1573,1595,"AAILIQSKFRSYYEQKKFQQSRR"],[1596,1618,"AAVLIQKYYRSYKKCGKRRQARR"],[1619,1641,"TAVIVQQKLRSSLLTKKQDQAAR"]]},{"c":"[GS]x[TL][PL]LxφAx[AS]xG[HY]φx[LA][AI]xxLx[KH][WL]x[RT]","u":25,"sp":"dispersed","x":"structured_like","cf":"high","why":"Three 25-residue structured repeats separated by variable linkers (20 aa and 9 aa), strongly anchored by invariant L5, A8, G12, L20 and conserved [TL][PL]L, G[HY]φ, and [KH][WL]x[RT] positions.","i":[[1065,1089,"GMTLLHLAAAQGYATLIQTLIKWRT"],[1110,1134,"SCTPLMWACALGHLEAAVVLYKWDR"],[1144,1168,"GRLPLGIARSRGHVKLAECLEHLQR"]]}],"s":"MWRAEGKWLPKTSRKSVSQSVFCGTSTYCVLNTVPPIEDDHGNSNSSHVKIFLPKKLLECLPKCSSLPKERHRWNTNEEIAAYLITFEKHEEWLTTSPKTRPQNGSMILYNRKKVKYRKDGYCWKKRKDGKTTREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVPAIEDCGKPCGPILCSINTDKKEWAKWTKEELIGQLKPMFHGIKWTCSNGNSSSGFSVEQLVQQILDSHQTKPQPRTHNCLCTGSLGAGGSVHHKCNSAKHRIISPKVEPRTGGYGSHSEVQHNDVSEGKHEHSHSKGSSREKRNGKVAKPVLLHQSSTEVSSTNQVEVPDTTQSSPVSISSGLNSDPDMVDSPVVTGVSGMAVASVMGSLSQSATVFMSEVTNEAVYTMSPTAGPNHHLLSPDASQGLVLAVSSDGHKFAFPTTGSSESLSMLPTNVSEELVLSTTLDGGRKIPETTMNFDPDCFLNNPKQGQTYGGGGLKAEMVSSNIRHSPPGERSFSFTTVLTKEIKTEDTSFEQQMAKEAYSSSAAAVAASSLTLTAGSSLLPSGGGLSPSTTLEQMDFSAIDSNKDYTSSFSQTGHSPHIHQTPSPSFFLQDASKPLPVEQNTHSSLSDSGGTFVMPTVKTEASSQTSSCSGHVETRIESTSSLHLMQFQANFQAMTAEGEVTMETSQAAEGSEVLLKSGELQACSSEHYLQPETNGVIRSAGGVPILPGNVVQGLYPVAQPSLGNASNMELSLDHFDISFSNQFSDLINDFISVEGGSSTIYGHQLVSGDSTALSQSEDGARAPFTQAEMCLPCCSPQQGSLQLSSSEGGASTMAYMHVAEVVSAASAQGTLGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEASNNYSCLFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAFNNQIISNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSILERLEQMERRMAEMTGSQQHKQASGGGSSGGGSGSGNGGSQAQCASGTGALGSCFESRVVVVCEKMMSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTLIKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGHVKLAECLEHLQRDEQAQLGQNPRIHCPASEEPSTESWMAQWHSEAISSPEIPKGVTVIASTNPELRRPRSEPSNYYSSESHKDYPAPKKHKLNPEYFQTRQEKLLPTALSLEEPNIRKQSPSSKQSVPETLSPSEGVRDFSRELSPPTPETAAFQASGSQPVGKWNSKDLYIGVSTVQVTGNPKGTSVGKEAAPSQVRPREPMSVLMMANREVVNTELGSYRDSAENEECGQPMDDIQVNMMTLAEHIIEATPDRIKQENFVPMESSGLERTDPATISSTMSWLASYLADADCLPSAAQIRSAYNEPLTPSSNTSLSPVGSPVSEIAFEKPNLPSAADWSEFLSASTSEKVENEFAQLTLSDHEQRELYEAARLVQTAFRKYKGRPLREQQEVAAAVIQRCYRKYKQYALYKKMTQAAILIQSKFRSYYEQKKFQQSRRAAVLIQKYYRSYKKCGKRRQARRTAVIVQQKLRSSLLTKKQDQAARKIMRFLRRCRHSPLVDHRLYKRSERIEKGQGT"},{"id":"SEQ_01012","a":"Q9NQV6","g":"PRDM10","d":"PR domain zinc finger protein 10","L":1147,"m":[{"c":"φxCxxCxxxΩxxxxxxxxHψ(x){2,3}H","u":"23-24","sp":"dispersed","x":"structured_like","cf":"high","why":"Ten 23-24 aa structured repeats anchored by invariant CxxC and Hψ(x){2,3}H coordination motifs alongside conserved N-terminal hydrophobic (φ) and central aromatic (Ω) positions, arranged in a 6-copy cluster plus four dispersed copies.","i":[[355,377,"WPCYECNRRFISSEQLQQHLNSH"],[530,552,"FKCLQCGKAFREKDKLDQHLRFH"],[560,582,"LTCDLCNKGFISSTSLESHMKLH"],[588,610,"YSCIFCPESFDRLDLLKDHVAIH"],[616,639,"FTCPTCKKRFPDFIQVKKHVRSFH"],[644,666,"YQCTECDKAFCRPDKLRLHMLRH"],[672,695,"FLCSTCGKQFKRKDKLREHMQRMH"],[727,750,"FKCRLCMMGFRRRGMLVNHLSKRH"],[772,795,"YFCQYCDKVYKSASKRKAHILKNH"],[834,857,"VCCPHCSKQYSSKTKMVQHIRKKH"]]}],"s":"MDSKDESSHVWPTSAEHEQNAAQVHFVPDTGTVAQIVYTDDQVRPPQQVVYTADGASYTSVDGPEHTLVYIHPVEAAQTLFTDPGQVAYVQQDATAQQASLPVHNQVLPSIESVDGSDPLATLQTPLGRLEAKEEEDEDEDEDTEEDEEEDGEDTDLDDWEPDPPRPFDPHDLWCEECNNAHASVCPKHGPLHPIPNRPVLTRARASLPLVLYIDRFLGGVFSKRRIPKRTQFGPVEGPLVRGSELKDCYIHLKVSLDKGDRKERDLHEDLWFELSDETLCNWMMFVRPAQNHLEQNLVAYQYGHHVYYTTIKNVEPKQELKVWYAASYAEFVNQKIHDISEEERKVLREQEKNWPCYECNRRFISSEQLQQHLNSHDEKLDVFSRTRGRGRGRGKRRFGPGRRPGRPPKFIRLEITSENGEKSDDGTQDLLHFPTKEQFDEAEPATLNGLDQPEQTTIPIPQLPQETQSSLEHEPETHTLHLQPQHEESVVPTQSTLTADDMRRAKRIRLELQNAALQHLFIRKSFRPFKCLQCGKAFREKDKLDQHLRFHGREGNCPLTCDLCNKGFISSTSLESHMKLHSDQKTYSCIFCPESFDRLDLLKDHVAIHINDGYFTCPTCKKRFPDFIQVKKHVRSFHSEKIYQCTECDKAFCRPDKLRLHMLRHSDRKDFLCSTCGKQFKRKDKLREHMQRMHNPEREAKKADRISRSKTFKPRITSTDYDSFTFKCRLCMMGFRRRGMLVNHLSKRHPDMKIEEVPELTLPIIKPNRDYFCQYCDKVYKSASKRKAHILKNHPGAELPPSIRKLRPAGPGEPDPMLSTHTQLTGTIATPPVCCPHCSKQYSSKTKMVQHIRKKHPEFAQLSNTIHTPLTTAVISATPAVLTTDSATGETVVTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHAIQVQHIQVSGQPLSPSAQQAQQGLSPSHIQGSSSTQGQALQQQQQQQQNSSVQHTYLPSAWNSFRGYSSEIQMMTLPPGQFVITDSGVATPVTTGQVKAVTSGHYVLSESQSELEEKQTSALSGGVQVEPPAHSDSLDPQTNSQQQTTQYIITTTTNGNGSSEVHITKP"},{"id":"SEQ_01016","a":"Q9UK76","g":"JPT1","d":"Jupiter microtubule associated homolog 1","L":154,"m":[{"c":"xPVP[AS]","u":5,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three copies of a 5-residue motif in the C-terminal disordered region anchored by an invariant PVP core and constrained [AS] C-terminal position, separated by 0 and 4 residues.","i":[[122,126,"KPVPA"],[127,131,"APVPS"],[136,140,"APVPS"]]}],"s":"MTTTTTFKGVDPNSRNSSRVLRPPGGGSNFSLGFDEPTEQPVRKNKMASNIFGTPEENQASWAKSAGAKSSGGREDLESSGLQRRNSSEASSGDFLDLKGEGDIHENVDTDLPGSLGQSEEKPVPAAPVPSPVAPAPVPSRRNPPGGKSSLVLG"},{"id":"SEQ_01028","a":"Q9Y4B5","g":"MTCL1","d":"Microtubule cross-linking factor 1","L":1905,"m":[{"c":"-L+x[QRH]L[KQ][FL][AV][KE]EEAxψψ[GR]+[KS]ψx[KE]ψ[EG]x[EH][KN][DR]xLxxEψx[DK]φ+","u":38,"sp":"periodic","x":"structured_like","cf":"high","why":"Three 38-residue internal duplications separated by regular 24-29 aa Pro/Gly-rich linkers, anchored by invariant L2, L6, EEA11-13, L30, and E33 alongside conserved aliphatic (ψ), hydrophobic (φ), and charged (+/-) positions distinct from generic coiled-coil background.","i":[[504,541,"DLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYK"],[566,603,"ELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMR"],[633,670,"ELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFK"]]}],"s":"METLNGPAGGGAPDAKLQPPGQHHRHHHLHPVAERRRLHRAPSPARPFLKDLHARPAAPGPAVPSSGRAPAPAAPRSPNLAGKAPPSPGSLAAPGRLSRRSGGVPGAKDKPPPGAGARAAGGAKAALGSRRAARVAPAEPLSRAGKPPGAEPPSAAAKGRKAKRGSRAPPARTVGPPTPAARIPAVTLAVTSVAGSPARCSRISHTDSSSDLSDCPSEPLSDEQRLLPAASSDAESGTGSSDREPPRGAPTPSPAARGAPPGSPEPPALLAAPLAAGACPGGRSIPSGVSGGFAGPGVAEDVRGRSPPERPVPGTPKEPSLGEQSRLVPAAEEEELLREMEELRSENDYLKDELDELRAEMEEMRDSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLEMEEEHLYALRWKELEMHSLALQNTLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQQLFSAFKALLEDFRAELREDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQLQKENSPRRGGSFLCDQKDGNVRPFPHQGSLRMPRPVAMWPCADADSIPFEDRPLSKLKESDRCSASENLYLDALSLDDEPEEPPAHRPEREFRNRLPEEEENHKGNLQRAVSVSSMSEFQRLMDISPFLPEKGLPSTSSKEDVTPPLSPDDLKYIEEFNKSWDYTPNRGHNGGGPDLWADRTEVGRAGHEDSTEPFPDSSWYLTTSVTMTTDTMTSPEHCQKQPLRSHVLTEQSGLRVLHSPPAVRRVDSITAAGGEGPFPTSRARGSPGDTKGGPPEPMLSRWPCTSPRHSRDYVEGARRPLDSPLCTSLGFASPLHSLEMSKNLSDDMKEVAFSVRNAICSGPGELQVKDMACQTNGSRTMGTQTVQTISVGLQTEALRGSGVTSSPHKCLTPKAGGGATPVSSPSRSLRSRQVAPAIEKVQAKFERTCCSPKYGSPKLQRKPLPKADQPNNRTSPGMAQKGYSESAWARSTTTRESPVHTTINDGLSSLFNIIDHSPVVQDPFQKGLRAGSRSRSAEPRPELGPGQETGTNSRGRSPSPIGVGSEMCREEGGEGTPVKQDLSAPPGYTLTENVARILNKKLLEHALKEERRQAAHGPPGLHSDSHSLGDTAEPGPMENQTVLLTAPWGL"},{"id":"SEQ_01035","a":"P78559","g":"MAP1A","d":"Microtubule-associated protein 1A","L":2803,"m":[{"c":"[QEP]KDxφ[LP]E","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Large tandem array of 28 heptapeptide repeats (residues 1362-1573, interrupted only by minor 6-aa and 10-aa phase-slip linkers and including a nearly identical 6-unit internal duplication) anchored by conserved K2, D3, hydrophobic position 5 (predominantly A/V/I), L/P at position 6, and E7 within a charged/proline-rich disordered region. Prolines at positions 1 and 6 (e.g., PKDKDLE, QKDKIPE, QTDKAPE) and the lack of an amphipathic a/d hydrophobic seam distinguish this repeat array from a coiled-coil heptad.","i":[[1362,1368,"PKDEVLQ"],[1369,1375,"QKDKTLE"],[1382,1388,"PKDTAIY"],[1389,1395,"QKDEALH"],[1396,1402,"VKNEAVK"],[1403,1409,"QQDKALE"],[1410,1416,"QKGRDLE"],[1417,1423,"QKDTALE"],[1424,1430,"QKDKALE"],[1431,1437,"PKDKDLE"],[1438,1444,"EKDKALE"],[1445,1451,"QKDKIPE"],[1452,1458,"EKDKALE"],[1459,1465,"QKDTALE"],[1466,1472,"QKDKALE"],[1473,1479,"PKDKDLE"],[1480,1486,"QKDRVLE"],[1487,1493,"QKEKIPE"],[1494,1500,"EKDKALD"],[1501,1507,"QKVRSVE"],[1518,1524,"MKDRDLE"],[1525,1531,"QTDKAPE"],[1532,1538,"QKHQAQE"],[1539,1545,"QKDKVSE"],[1546,1552,"KKDQALE"],[1553,1559,"QKYWALG"],[1560,1566,"QKDEALE"],[1567,1573,"QNIQALE"]]}],"s":"MDGVAEFSEYVSETVDVPSPFDLLEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNILVDGGSDRKSCFWKLVRHLDRIDSVLLTHIGADNLPGINGLLQRKVAELEEEQSQGSSSYSDWVKNLISPELGVVFFNVPEKLRLPDASRKAKRSIEEACLTLQHLNRLGIQAEPLYRVVSNTIEPLTLFHKMGVGRLDMYVLNPVKDSKEMQFLMQKWAGNSKAKTGIVLPNGKEAEISVPYLTSITALVVWLPANPTEKIVRVLFPGNAPQNKILEGLEKLRHLDFLRYPVATQKDLASGAVPTNLKPSKIKQRADSKESLKATTKTAVSKLAKREEVVEEGAKEARSELAKELAKTEKKAKESSEKPPEKPAKPERVKTESSEALKAEKRKLIKDKVGKKHLKEKISKLEEKKDKEKKEIKKERKELKKDEGRKEEKKDAKKEEKRKDTKPELKKISKPDLKPFTPEVRKTLYKAKVPGRVKIDRSRAIRGEKELSSEPQTPPAQKGTVPLPTISGHRELVLSSPEDLTQDFEEMKREERALLAEQRDTGLGDKPFPLDTAEEGPPSTAIQGTPPSVPGLGQEEHVMKEKELVPEVPEEQGSKDRGLDSGAETEEEKDTWEEKKQREAERLPDRTEAREESEPEVKEDVIEKAELEEMEEVHPSDEEEEDATKAEGFYQKHMQEPLKVTPRSREAFGGRELGLQGKAPEKETSLFLSSLTTPAGATEHVSYIQDETIPGYSETEQTISDEEIHDEPEERPAPPRFHTSTYDLPGPEGAGPFEASQPADSAVPATSGKVYGTPETELTYPTNIVAAPLAEEEHVSSATSITECDKLSSFATSVAEDQSVASLTAPQTEETGKSSLLLDTVTSIPSSRTEATQGLDYVPSAGTISPTSSLEEDKGFKSPPCEDFSVTGESEKRGEIIGKGLSGERAVEEEEEETANVEMSEKLCSQYGTPVFSAPGHALHPGEPALGEAEERCLSPDDSTVKMASPPPSGPPSATHTPFHQSPVEEKSEPQDFQEADSWGDTKRTPGVGKEDAAEETVKPGPEEGTLEKEEKVPPPRSPQAQEAPVNIDEGLTGCTIQLLPAQDKAIVFEIMEAGEPTGPILGAEALPGGLRTLPQEPGKPQKDEVLRYPDRSLSPEDAESLSVLSVPSPDTANQEPTPKSPCGLTEQYLHKDRWPEVSPEDTQSLSLSEESPSKETSLDVSSKQLSPESLGTLQFGELNLGKEEMGHLMQAEDTSHHTAPMSVPEPHAATASPPTDGTTRYSAQTDITDDSLDRKSPASSFSHSTPSGNGKYLPGAITSPDEHILTPDSSFSKSPESLPGPALEDIAIKWEDKVPGLKDRTSEQKKEPEPKDEVLQQKDKTLEHKEVVEPKDTAIYQKDEALHVKNEAVKQQDKALEQKGRDLEQKDTALEQKDKALEPKDKDLEEKDKALEQKDKIPEEKDKALEQKDTALEQKDKALEPKDKDLEQKDRVLEQKEKIPEEKDKALDQKVRSVEHKAPEDTVAEMKDRDLEQTDKAPEQKHQAQEQKDKVSEKKDQALEQKYWALGQKDEALEQNIQALEENHQTQEQESLVQEDKTRKPKMLEEKSPEKVKAMEEKLEALLEKTKALGLEESLVQEGRAREQEEKYWRGQDVVQEWQETSPTREEPAGEQKELAPAWEDTSPEQDNRYWRGREDVALEQDTYWRELSCERKVWFPHELDGQGARPHYTEERESTFLDEGPDDEQEVPLREHATRSPWASDFKDFQESSPQKGLEVERWLAESPVGLPPEEEDKLTRSPFEIISPPASPPEMVGQRVPSAPGQESPIPDPKLMPHMKNEPTTPSWLADIPPWVPKDRPLPPAPLSPAPGPPTPAPESHTPAPFSWGTAEYDSVVAAVQEGAAELEGGPYSPLGKDYRKAEGEREEEGRAEAPDKSSHSSKVPEASKSHATTEPEQTEPEQREPTPYPDERSFQYADIYEQMMLTGLGPACPTREPPLGAAGDWPPCLSTKEAAAGRNTSAEKELSSPISPKSLQSDTPTFSYAALAGPTVPPRPEPGPSMEPSLTPPAVPPRAPILSKGPSPPLNGNILSCSPDRRSPSPKESGRSHWDDSTSDSELEKGAREQPEKEAQSPSPPHPIPMGSPTLWPETEAHVSPPLDSHLGPARPSLDFPASAFGFSSLQPAPPQLPSPAEPRSAPCGSLAFSGDRALALAPGPPTRTRHDEYLEVTKAPSLDSSLPQLPSPSSPGAPLLSNLPRPASPALSEGSSSEATTPVISSVAERFSPSLEAAEQESGELDPGMEPAAHSLWDLTPLSPAPPASLDLALAPAPSLPGDMGDGILPCHLECSEAATEKPSPFQVPSEDCAANGPTETSPNPPGPAPAKAENEEAAACPAWERGAWPEGAERSSRPDTLLSPEQPVCPAGGSGGPPSSASPEVEAGPQGCATEPRPHRGELSPSFLNPPLPPSIDDRDLSTEEVRLVGRGGRRRVGGPGTTGGPCPVTDETPPTSASDSGSSQSDSDVPPETEECPSITAEAALDSDEDGDFLPVDKAGGVSGTHHPRPGHDPPPLPQPDPRPSPPRPDVCMADPEGLSSESGRVERLREKEKVQGRVGRRAPGKAKPASPARRLDLRGKRSPTPGKGPADRASRAPPRPRSTTSQVTPAEEKDGHSPMSKGLVNGLKAGPMALSSKGSSGAPVYVDLAYIPNHCSGKTADLDFFRRVRASYYVVSGNDPANGEPSRAVLDALLEGKAQWGENLQVTLIPTHDTEVTREWYQQTHEQQQQLNVLVLASSSTVVMQDESFPACKIEF"},{"id":"SEQ_01057","a":"Q05707","g":"COL14A1","d":"Collagen alpha-1(XIV) chain","L":1796,"m":[{"c":"(x){4,5}LxxxxxxxxxxxφxW(x){8,9}[YFH]xψxφ(x){22,27}[GNP]Lx[PS]xx[EDN]Yx[VI]xψ(x){17,18}[TI]xx[LVS]","u":"88-94","sp":"dispersed","x":"structured_like","cf":"high","why":"Eight ~90-aa structured repeats anchored by invariant L, W, and Y cores ([GNP]Lx[PS]xx[EDN]Yx[VI]xψ) plus conserved hydrophobic beta-strand registers; copies 2-5 and 6-8 form tandem arrays while copy 1 and copy 6 are separated by an inserted domain and a 20-aa linker.","i":[[31,120,"APPTRLRYNVISHDSIQISWKAPRGKFGGYKLLVTPTSGGKTNQLNLQNTATKAIIQGLMPDQNYTVQIIAYNKDKESKPAQGQFRIKDL"],[354,443,"GPPTELITSEVTARSFMVNWTHAPGNVEKYRVVYYPTRGGKPDEVVVDGTVSSTVLKNLMSLTEYQIAVFAIYAHTASEGLRGTETTLAL"],[444,535,"PMASDLLLYDVTENSMRVKWDAVPGASGYLILYAPLTEGLAGDEKEMKIGETHTDIELSGLLPNTEYTVTVYAMFGEEASDPVTGQETTLAL"],[536,624,"SPPRNLRISNVGSNSARLTWDPTSRQINGYRIVYNNADGTEINEVEVDPITTFPLKGLTPLTEYTIAIFSIYDEGQSEPLTGVFTTEEV"],[625,715,"PAQQYLEIDEVTTDSFRVTWHPLSADEGLHKLMWIPVYGGKTEEVVLKEEQDSHVIEGLEPGTEYEVSLLAVLDDGSESEVVTAVGTTLDS"],[736,829,"TGIRNLVVGDETTSSLRVKWDISDSDVQQFRVTYMTAQGDPEEEVIGTVMVPGSQNNLLLKPLLPDTEYKVTVTPIYTDGEGVSVSAPGKTLPS"],[830,920,"SGPQNLRVSEEWYNRLRITWDPPSSPVKGYRIVYKPVSVPGPTLETFVGADINTILITNLLSGMDYNVKIFASQASGFSDALTGMVKTLFL"],[921,1008,"GVTNLQAKHVEMTSLCAHWQVHRHATAYRVVIESLQDRQKQESTVGGGTTRHCFYGLQPDSEYKISVYTKLQEIEGPSVSIMEKTQSL"]]},{"c":"ADψVφψVDGSWSIGxxNFxxψxxFLxoxVxAφ[DN](x){5,6}Txψ[GA]ψφQΩ[ST][GD]DPRxEΩxLNAΩxTK-xψψ-Aψ+xψ[PS]YKGGNTxTGxAψxYψx-oxFxxE[AS]G[ST]RxGψ[SP]KψxψψITDG+SQDDψxxxSRxψxxxGφxψFAIGVx[ND]ADφoELxxI[AG]SxPx[SA]xHVΩxVx-FDφφxxψx-xLxxxψC","u":"179-180","sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 179-180 aa globular domains separated by the central repeat array, sharing extensive invariant motifs including VDGSWSIG, YKGGNTxTGxA, ITDG+SQDD, FAIGV, and a C-terminal cysteine.","i":[[157,335,"ADIVILVDGSWSIGRFNFRLVRHFLENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNAFSTKDEVIEAVRNLPYKGGNTLTGLALNYIFENSFKPEAGSRTGVSKIGILITDGKSQDDIIPPSRNLRESGVELFAIGVKNADVNELQEIASEPDSTHVYNVAEFDLMHTVVESLTRTLC"],[1031,1210,"ADLVFMVDGSWSIGDENFNKIISFLYSTVGALNKIGTDGTQVAMVQFTDDPRTEFKLNAYKTKETLLDAIKHISYKGGNTKTGKAIKYVRDTLFTAESGTRRGIPKVIVVITDGRSQDDVNKISREMQLDGYSIFAIGVADADYSELVSIGSKPSARHVFFVDDFDAFKKIEDELITFVC"]]}],"s":"MKIFQRKMRYWLLPPFLAIVYFCTIVQGQVAPPTRLRYNVISHDSIQISWKAPRGKFGGYKLLVTPTSGGKTNQLNLQNTATKAIIQGLMPDQNYTVQIIAYNKDKESKPAQGQFRIKDLEKRKDPKPRVKVVDRGNGSRPSSPEEVKFVCQTPAIADIVILVDGSWSIGRFNFRLVRHFLENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNAFSTKDEVIEAVRNLPYKGGNTLTGLALNYIFENSFKPEAGSRTGVSKIGILITDGKSQDDIIPPSRNLRESGVELFAIGVKNADVNELQEIASEPDSTHVYNVAEFDLMHTVVESLTRTLCSRVEEQDREIKASAHAITGPPTELITSEVTARSFMVNWTHAPGNVEKYRVVYYPTRGGKPDEVVVDGTVSSTVLKNLMSLTEYQIAVFAIYAHTASEGLRGTETTLALPMASDLLLYDVTENSMRVKWDAVPGASGYLILYAPLTEGLAGDEKEMKIGETHTDIELSGLLPNTEYTVTVYAMFGEEASDPVTGQETTLALSPPRNLRISNVGSNSARLTWDPTSRQINGYRIVYNNADGTEINEVEVDPITTFPLKGLTPLTEYTIAIFSIYDEGQSEPLTGVFTTEEVPAQQYLEIDEVTTDSFRVTWHPLSADEGLHKLMWIPVYGGKTEEVVLKEEQDSHVIEGLEPGTEYEVSLLAVLDDGSESEVVTAVGTTLDSFWTEPATTIVPTTSVTSVFQTGIRNLVVGDETTSSLRVKWDISDSDVQQFRVTYMTAQGDPEEEVIGTVMVPGSQNNLLLKPLLPDTEYKVTVTPIYTDGEGVSVSAPGKTLPSSGPQNLRVSEEWYNRLRITWDPPSSPVKGYRIVYKPVSVPGPTLETFVGADINTILITNLLSGMDYNVKIFASQASGFSDALTGMVKTLFLGVTNLQAKHVEMTSLCAHWQVHRHATAYRVVIESLQDRQKQESTVGGGTTRHCFYGLQPDSEYKISVYTKLQEIEGPSVSIMEKTQSLPTRPPTFPPTIPPAKEVCKAAKADLVFMVDGSWSIGDENFNKIISFLYSTVGALNKIGTDGTQVAMVQFTDDPRTEFKLNAYKTKETLLDAIKHISYKGGNTKTGKAIKYVRDTLFTAESGTRRGIPKVIVVITDGRSQDDVNKISREMQLDGYSIFAIGVADADYSELVSIGSKPSARHVFFVDDFDAFKKIEDELITFVCETASATCPVVHKDGIDLAGFKMMEMFGLVEKDFSSVEGVSMEPGTFNVFPCYQLHKDALVSQPTRYLHPEGLPSDYTISFLFRILPDTPQEPFALWEILNKNSDPLVGVILDNGGKTLTYFNYDQSGDFQTVTFEGPEIRKIFYGSFHKLHIVVSETLVKVVIDCKQVGEKAMNASANITSDGVEVLGKMVRSRGPGGNSAPFQLQMFDIVCSTSWANTDKCCELPGLRDDESCPDLPHSCSCSETNEVALGPAGPPGGPGLRGPKGQQGEPGPKGPDGPRGEIGLPGPQGPPGPQGPSGLSIQGMPGMPGEKGEKGDTGLPGPQGIPGGVGSPGRDGSPGQRGLPGKDGSSGPPGPPGPIGIPGTPGVPGITGSMGPQGALGPPGVPGAKGERGERGDLQSQAMVRSVARQVCEQLIQSHMARYTAILNQIPSHSSSIRTVQGPPGEPGRPGSPGAPGEQGPPGTPGFPGNAGVPGTPGERGLTGIKGEKGNPGVGTQGPRGPPGPAGPSGESRPGSPGPPGSPGPRGPPGHLGVPGPQGPSGQPGYCDPSSCSAYGVRAPHPDQPEFTPVQDELEAMELWGPGV"},{"id":"SEQ_01058","a":"O94819","g":"KBTBD11","d":"Kelch repeat and BTB domain-containing protein 11","L":623,"m":[{"c":"xx[VL]xx[FY]xxxxxxW(x){3,6}P(x){16,21}[LI][FY]xxxx","u":"40-46","sp":"dispersed","x":"structured_like","cf":"high","why":"Five 40-46 aa structured repeats in the C-terminal half defined by a strict [VL]xx[FY]xxxxxxW motif, a conserved downstream P, and a C-terminal [LI][FY]xxxx hydrophobic-aromatic dyad (often followed by GG or preceded by ALDGx), separated by short variable linkers (3-14 aa).","i":[[325,366,"AAVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGG"],[380,419,"DQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG"],[423,464,"LSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGG"],[468,507,"YRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDL"],[522,567,"VSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCVSR"]]},{"c":"A[SC]PEE[LRP]","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Four 6-aa repeats in the N-terminal disordered tail sharing invariant A, P, and EE anchors (A[SC]PEE[LRP]), arranged as three head-to-tail tandem copies followed by a fourth copy after a 14-aa linker.","i":[[86,91,"ASPEEL"],[92,97,"ASPEER"],[98,103,"ACPEEP"],[118,123,"ASPEEP"]]}],"s":"MEHAVAPCVLYPGTEPGAAGESESEGAASPAQTPCSLGASLCFSSGEESPPQSLASAAEGAATSPPSSGGPRVVERQWEAGSAGAASPEELASPEERACPEEPAAPSPEPRVWLEDPASPEEPGEPAPVPPGFGAVYGEPDLVLEVSGRRLRAHKAVLAARSDYFRARASRDVLRVQGVSLTALRLLLADAYSGRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRDAAYCFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLRAGRAHLLAAALGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCVSRAGTWRFQPAREGEAGGDAGQGGGFEALGAPLDVRGVLIPFALSLPEKPPRGEQGAP"},{"id":"SEQ_01085","a":"Q765P7","g":"MTSS2","d":"Protein MTSS 2","L":747,"m":[{"c":"[AT]GLP[ST]","u":5,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three tandem 5-aa copies (with a 1-residue gap before the third copy) in a disordered P/S/T-rich region share an invariant GLP tripeptide core flanked by [AT] at position 1 and hydroxyl [ST] at position 5.","i":[[540,544,"AGLPT"],[545,549,"AGLPT"],[551,555,"TGLPS"]]}],"s":"METAEKECGALGGLFQAIVNDMKSSYPIWEDFNSKATKLHSQLRTTVLAAVAFLDAFQKVADMATNTRGATRDIGSALTRMCMRHRSIETKLRQFTNALLESLINPLQERIEDWKKAANQLDKDHAKEYKRARHEIKKKSSDTLKLQKKARKELLGKGDLQPQLDSALQDVNDMYLLLEETEKQAVRRALIEERGRFCTFITFLQPVVNGELTMLGEITHLQGIIDDLVVLTAEPHKLPPASEQVIKDLKGSDYSWSYQTPPSSPSSSSSRKSSMCSAPSSSSSAKGGGAPWPGGAQTYSPSSTCRYRSLAQPATTTARLSSVSSHDSGFVSQDATYSKPPSPMPSDITSQKSSSSASSEASETCQSVSECSSPTSDWSKVGSHEQPSGATLQRRKDRVELLRDTEPGPASGGTLGPSGEEAPRPRMSPATIAAKHGEEVSPAASDLAMVLTRGLSLEHQKSSRDSLQYSSGYSTQTTTPSCSEDTIPSQGSDYDCYSVNGDADSEGPPEFDKSSTIPRNSNIAQNYRRLIQTKRPASTAGLPTAGLPTATGLPSGAPPGVATIRRTPSTKPTVRRALSSAGPIPIRPPIVPVKTPTVPDSPGYMGPTRAGSEECVFYTDETASPLAPDLAKASPKRLSLPNTAWGSPSPEAAGYPGAGAEDEQQQLAANRHSLVEKLGELVAGAHALGEGQFPFPTALSATPTEETPTPPPAATSDPPAEDMLVAIRRGVRLRRTVTNDRSAPRIL"},{"id":"SEQ_01088","a":"Q86XN8","g":"MEX3D","d":"RNA-binding protein MEX3D","L":651,"m":[{"c":"V[PR]VP(x){6,7}ψVGxxGxxIKxψxx+TxTYIxTPxRxxEPVFφVTGxxExV-xA+xEI","u":"57-58","sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 57-58 aa globular domain repeats separated by a 37 aa linker, anchored by N-terminal V[PR]VP, a ψVGxxGxxIK motif, invariant TxTYIxTPxRxxEPVFφVTG core positions, and a C-terminal ExV-xA+xEI helix-like segment.","i":[[183,240,"VPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFIVTGRKEDVEMAKREI"],[278,334,"VRVPYRVVGLVVGPKGATIKRIQQRTHTYIVTPGRDKEPVFAVTGMPENVDRAREEI"]]}],"s":"MPSSLGQPDGGGGGGGGGGGVGAAGEDPGPGPAPPPEGAQEAAPAPRPPPEPDDAAAALRLALDQLSALGLGGAGDTDEEGAAGDGAAAAGGADGGAAPEPVPPDGPEAGAPPTLAPAVAPGSLPLLDPNASPPPPPPPRPSPPDVFAGFAPHPAALGPPTLLADQMSVIGSRKKSVNMTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFIVTGRKEDVEMAKREILSAAEHFSIIRATRSKAGGLPGAAQGPPNLPGQTTIQVRVPYRVVGLVVGPKGATIKRIQQRTHTYIVTPGRDKEPVFAVTGMPENVDRAREEIEAHITLRTGAFTDAGPDSDFHANGTDVCLDLLGAAASLWAKTPNQGRRPPTATAGLRGDTALGAPSAPEAFYAGSRGGPSVPDPGPASPYSGSGNGGFAFGAEGPGAPVGTAAPDDCDFGFDFDFLALDLTVPAAATIWAPFERAAPLPAFSGCSTVNGAPGPPAAGARRSSGAGTPRHSPTLPEPGGLRLELPLSRRGAPDPVGALSWRPPQGPVSFPGGAAFSTATSLPSSPAAAACAPLDSGASENSRKPPSASSAPALARECVVCAEGEVMAALVPCGHNLFCMDCAVRICGKSEPECPACRTPATQAIHIFS"},{"id":"SEQ_01091","a":"Q96GP6","g":"SCARF2","d":"Scavenger receptor class F member 2","L":871,"m":[{"c":"C(x){1,2}C(x){4,5}CxxxxGxC(x){1,2}Cx[PA]GφxGxxCxxxC[PAS]xGx[YH]Gx[GD]C","u":"39-42","sp":"periodic","x":"structured_like","cf":"high","why":"Four consecutive 8-cysteine repeats separated by regular 3 aa linkers, each combining the conserved 6-cysteine core with a C-terminal C[PAS]xGx[YH]Gx[GD]C disulfide-like submodule and three invariant glycines.","i":[[244,282,"CQCFRGRCHPVDGTCACEPGYRGKYCREPCPAGFYGLGC"],[286,327,"CGQCKGQQPCTVAEGRCLTCEPGWNGTKCDQPCATGFYGEGC"],[331,372,"CPPCRDGHACNHVTGKCTRCNAGWIGDRCETKCSNGTYGEDC"],[376,415,"CADCGSGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHGADC"]]},{"c":"CxC(x){4,5}C[EDH]xx[ST]GxCxC[HER][APE][GR]x[WF]G[AR]xC","u":"26-27","sp":"periodic","x":"structured_like","cf":"high","why":"Four consecutive 6-cysteine repeats immediately N-terminal to the 8-cysteine array and separated by regular 3 aa linkers, anchored by six invariant cysteines, two invariant glycines, and a conserved [WF]G aromatic-glycine pair.","i":[[126,152,"CSCHPHGQCEDVTGQCTCHARRWGARC"],[156,181,"CQCQHGTCHPRSGACRCEPGWWGAQC"],[185,211,"CYCSATSRCDPQTGACLCHAGWWGRSC"],[215,240,"CACNSSPCEQQSGRCQCRERTFGARC"]]}],"s":"MEGAGPRGAGPARRRGAGGPPSPLLPSLLLLLLLWMLPDTVAPQELNPRGRNVCRAPGSQVPTCCAGWRQQGDECGIAVCEGNSTCSENEVCVRPGECRCRHGYFGANCDTKCPRQFWGPDCKELCSCHPHGQCEDVTGQCTCHARRWGARCEHACQCQHGTCHPRSGACRCEPGWWGAQCASACYCSATSRCDPQTGACLCHAGWWGRSCNNQCACNSSPCEQQSGRCQCRERTFGARCDRYCQCFRGRCHPVDGTCACEPGYRGKYCREPCPAGFYGLGCRRRCGQCKGQQPCTVAEGRCLTCEPGWNGTKCDQPCATGFYGEGCSHRCPPCRDGHACNHVTGKCTRCNAGWIGDRCETKCSNGTYGEDCAFVCADCGSGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHGADCAQACSCHEDTCDPVTGACHLETNQRKGVMGAGALLVLLVCLLLSLLGCCCACRGKDPTRRPRPRRELSLGRKKAPHRLCGRFSRISMKLPRIPLRRQKLPKVVVAHHDLDNTLNCSFLEPPSGLEQPSPSWSSRASFSSFDTTDEGPVYCVPHEEAPAESRDPEVPTVPAEAPAPSPVPLTTPASAEEAIPLPASSDSERSASSVEGPGGALYARVARREARPARARGEIGGLSLSPSPERRKPPPPDPATKPKVSWIHGKHSAAAAGRAPSPPPPGSEAAPSPSKRKRTPSDKSAHTVEHGSPRTRDPTPRPPGLPEEATALAAPSPPRARARGRGPGLLEPTDAGGPPRSAPEAASMLAAELRGKTRSLGRAEVALGAQGPREKPAPPQKAKRSVPPASPARAPPATETPGPEKAATDLPAPETPRKKTPIQKPPRKKSREAAGELGRAGAPTL"},{"id":"SEQ_01093","a":"O15055","g":"PER2","d":"Period circadian protein homolog 2","L":1255,"m":[{"c":"[QS]xxFPS","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four copies (residues 910-951, including the head-to-tail tandem pair QAFFPS-QPQFPS) within a proline/serine-rich disordered region share an invariant FPS tripeptide preceded by a conserved [QS] anchor three residues upstream (and followed by [PT] two residues downstream).","i":[[910,915,"SYSFPS"],[922,927,"QAFFPS"],[928,933,"QPQFPS"],[946,951,"QPEFPS"]]},{"c":"[PV][PV]FPAP[GLV]","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed copies immediately N-terminal to the FPS array (residues 844-900) share an invariant FPAP core flanked by two [PV] positions on the N-terminal side and a small/aliphatic [GLV] residue on the C-terminal side, forming a related FP[AS]-type sub-array within the same proline-rich region.","i":[[844,850,"VPFPAPV"],[857,863,"PVFPAPG"],[894,900,"PPFPAPL"]]}],"s":"MNGYAEFPPSPSNPTKEPVEPQPSQVPLQEDVDMSSGSSGHETNENCSTGRDSQGSDCDDSGKELGMLVEPPDARQSPDTFSLMMAKSEHNPSTSGCSSDQSSKVDTHKELIKTLKELKVHLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSEGHPCGADVPSYTVEEMESVTSEHIVKNADMFAVAVSLVSGKILYISDQVASIFHCKRDAFSDAKFVEFLAPHDVGVFHSFTSPYKLPLWSMCSGADSFTQECMEEKSFFCRVSVRKSHENEIRYHPFRMTPYLVKVRDQQGAESQLCCLLLAERVHSGYEAPRIPPEKRIFTTTHTPNCLFQDVDERAVPLLGYLPQDLIETPVLVQLHPSDRPLMLAIHKKILQSGGQPFDYSPIRFRARNGEYITLDTSWSSFINPWSRKISFIIGRHKVRVGPLNEDVFAAHPCTEEKALHPSIQELTEQIHRLLLQPVPHSGSSGYGSLGSNGSHEHLMSQTSSSDSNGHEDSRRRRAEICKNGNKTKNRSHYSHESGEQKKKSVTEMQTNPPAEKKAVPAMEKDSLGVSFPEELACKNQPTCSYQQISCLDSVIRYLESCNEAATLKRKCEFPANVPALRSSDKRKATVSPGPHAGEAEPPSRVNSRTGVGTHLTSLALPGKAESVASLTSQCSYSSTIVHVGDKKPQPELEMVEDAASGPESLDCLAGPALACGLSQEKEPFKKLGLTKEVLAAHTQKEEQSFLQKFKEIRKLSIFQSHCHYYLQERSKGQPSERTAPGLRNTSGIDSPWKKTGKNRKLKSKRVKPRDSSESTGSGGPVSARPPLVGLNATAWSPSDTSQSSCPAVPFPAPVPAAYSLPVFPAPGTVAAPPAPPHASFTVPAVPVDLQHQFAVQPPPFPAPLAPVMAFMLPSYSFPSGTPNLPQAFFPSQPQFPSHPTLTSEMASASQPEFPSRTSIPRQPCACPATRATPPSAMGRASPPLFQSRSSSPLQLNLLQLEEAPEGGTGAMGTTGATETAAVGADCKPGTSRDQQPKAPLTRDEPSDTQNSDALSTSSGLLNLLLNEDLCSASGSAASESLGSGSLGCDASPSGAGSSDTSHTSKYFGSIDSSENNHKAKMNTGMEESEHFIKCVLQDPIWLLMADADSSVMMTYQLPSRNLEAVLKEDREKLKLLQKLQPRFTESQKQELREVHQWMQTGGLPAAIDVAECVYCENKEKGNICIPYEEDIPSLGLSEVSDTKEDENGSPLNHRIEEQT"},{"id":"SEQ_01106","a":"Q01546","g":"KRT76","d":"Keratin, type II cytoskeletal 2 oral","L":638,"m":[{"c":"FGG[AP]G[GVS]","u":6,"sp":"tandem","x":"disordered_like","cf":"high","why":"Five contiguous head-to-tail hexapeptide repeats in the N-terminal disordered head domain, anchored by an invariant Phe, conserved Gly positions, and a constrained [AP] position.","i":[[116,121,"FGGAGG"],[122,127,"FGGAGG"],[128,133,"FGGPGV"],[134,139,"FGGPGS"],[140,145,"FGGPGG"]]}],"s":"MNRQVCKKSFSGRSQGFSGRSAVVSGSSRMSCVARSGGAGGGACGFRSGAGSFGSRSLYNLGSNKSISISVAAGSSRAGGFGGGRSSCGFAGGYGGGFGGSYGGGFGGGRGVGSGFGGAGGFGGAGGFGGPGVFGGPGSFGGPGGFGPGGFPGGIQEVIVNQSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWELLQQQTTGSGPSSLEPCFESYISFLCKQLDSLLGERGNLEGELKSMQDLVEDFKKKYEDEINKRTAAENEFVGLKKDVDAAFMNKVELQAKVDSLTDEVSFLRTLYEMELSQMQSHASDTSVVLSMDNNRCLDLGSIIAEVRAQYEEIAQRSKSEAEALYQTKLGELQTTAGRHGDDLRNTKSEIMELNRMIQRLRAEIENVKKQNANLQTAIAEAEQRGEMALKDANAKLQDLQTALQKAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGECQSAVCISVVSNVTSTSGSSGSSRGVFGGVSGSGSGGYKGGSSSSSSSGYGVSGGSGSGYGGVSSGSTGGRGSSGSYQSSSSGSRLGGAGSISVSHSGMGSSSGSIQTSGGSGYKSGGGGSTSIRFSQTTSSSQHSSTK"},{"id":"SEQ_01119","a":"Q01101","g":"INSM1","d":"Insulinoma-associated protein 1","L":510,"m":[{"c":"[FYH]xCxxCxxx[FY]xxxxx[LQ]xxH(x){1,4}[HC]","u":"21-24","sp":"dispersed","x":"structured_like","cf":"high","why":"Five dispersed 21-24 aa zinc-finger-like repeats in the C-terminal half anchored by invariant CxxC, conserved aromatic [FY] at +4 after the second Cys, conserved [LQ] at +10, invariant His at +13, and a terminal [HC] ligand separated by a 1-4 residue loop.","i":[[267,287,"FICQLCKEEYADPFALAQHKC"],[295,317,"YRCPECAKVFSCPANLASHRRWH"],[367,389,"YECHHCAKKFRRQAYLRKHLLAH"],[441,464,"HLCPVCGESFASKGAQERHLRLLH"],[469,492,"FPCKYCPATFYSSPGLTRHINKCH"]]}],"s":"MPRGFLVKRSKKSTPVSYRVRGGEDGDRALLLSPSCGGARAEPPAPSPVPGPLPPPPPAERAHAALAAALACAPGPQPPPQGPRAAHFGNPEAAHPAPLYSPTRPVSREHEKHKYFERSFNLGSPVSAESFPTPAALLGGGGGGGASGAGGGGTCGGDPLLFAPAELKMGTAFSAGAEAARGPGPGPPLPPAAALRPPGKRPPPPTAAEPPAKAVKAPGAKKPKAIRKLHFEDEVTTSPVLGLKIKEGPVEAPRGRAGGAARPLGEFICQLCKEEYADPFALAQHKCSRIVRVEYRCPECAKVFSCPANLASHRRWHKPRPAPAAARAPEPEAAARAEAREAPGGGSDRDTPSPGGVSESGSEDGLYECHHCAKKFRRQAYLRKHLLAHHQALQAKGAPLAPPAEDLLALYPGPDEKAPQEAAGDGEGAGVLGLSASAECHLCPVCGESFASKGAQERHLRLLHAAQVFPCKYCPATFYSSPGLTRHINKCHPSENRQVILLQVPVRPAC"},{"id":"SEQ_01121","a":"Q6ZSJ9","g":"SHISA6","d":"Protein shisa-6","L":500,"m":[{"c":"xxxDxφψS[PDT][DEP]x","u":11,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four clustered 11-aa repeats in the disordered C-terminal tail separated by 7-12 aa linkers, anchored by invariant Asp and Ser flanking a conserved hydrophobic-aliphatic dipeptide (DxφψS) and constrained polar/proline/acidic C-terminal positions (with extended 21-aa similarity across copies 1 and 3).","i":[[366,376,"MSQDRVLSPDR"],[384,394,"MPYDRILSDEQ"],[402,412,"HSQDPLLSPER"],[425,435,"SHTDVFVSTPV"]]}],"s":"MALRRLLLLLLLSLESLDLLPSVHGARGRAANRTLSAGGAAVGGRRAGGALARGGRELNGTARAPGIPEAGSRRGQPAAAVAAAASAAVTYETCWGYYDVSGQYDKEFECNNSESGYLYCCGTCYYRFCCKKRHEKLDQRQCTNYQSPVWVQTPSTKVVSPGPENKYDPEKDKTNFTVYITCGVIAFVIVAGVFAKVSYDKAHRPPREMNIHRALADILRQQGPIPIAHCERETISAIDTSPKENTPVRSSSKNHYTPVRTAKQTPEKPRMNNILTSATEPYDLSFSRSFQNLAHLPPSYESAVKTNPSKYSSLKRLTDKEADEYYMRRRHLPDLAARGTLPLNVIQMSQQKPLPRERPRRPIRAMSQDRVLSPDRGLPDEFSMPYDRILSDEQLLSTERLHSQDPLLSPERTAFPEQSLSRAISHTDVFVSTPVLDRYRMSKMHSHPSASNNSYATLGQSQTAAKRHAFASRRHNTVEQLHYIPGHHTCYTASKTEVTV"},{"id":"SEQ_01147","a":"A6NI72","g":"NCF1B","d":"Putative neutrophil cytosol factor 1B","L":391,"m":[{"c":"YxAIxxYxxxxGxEψxLxxG-φVEVψxKxxxGWWφxxxxxxxGΩφPxxΩL","u":50,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two ungapped 50-residue structured repeats separated by a 20-residue acidic/proline-rich linker, anchored by conserved YxAIxxY, GxEψxL, G-φVEVψxK, GWWφ, and C-terminal GΩφPxxΩL motifs.","i":[[162,211,"YRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFL"],[232,281,"YVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYL"]]}],"s":"MGDTFIRHIALLGFEKRFVPSQHYVRYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPHLPAPKWFDGQRAAENHQGTLTEYCGTLMSLPTKISRCPHLLDFFKVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNVHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSKPQPAVPPRPSADLILNRCSESTKRKLASAV"},{"id":"SEQ_01149","a":"Q9UGP4","g":"LIMD1","d":"LIM domain-containing protein 1","L":676,"m":[{"c":"CφxC[GS]xxψφ(x){10,17}YHxxCΩxCxxCxxxL(x){11,14}ψΩCxx[CD][FHY]","u":"53-62","sp":"periodic","x":"structured_like","cf":"high","why":"Three C-terminal cysteine/histidine-rich structured repeats separated by short 7-11 aa linkers, sharing an N-terminal CφxC[GS]xxψφ motif, an invariant 11-residue YHxxCΩxCxxC central core followed by a conserved L at +4, and a C-terminal ψΩCxx[CD][FHY] motif across two variable-length loops.","i":[[472,525,"CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDF"],[537,589,"CFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDY"],[597,658,"CAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLEDHLFCHSCH"]]}],"s":"MDKYDDLGLEASKFIEDLNMYEASKDGLFRVDKGAGNNPEFEETRRVFATKMAKIHLQQQQQQLLQEETLPRGSRGPVNGGGRLGPQARWEVVGSKLTVDGAAKPPLAASTGAPGAVTTLAAGQPPYPPQEQRSRPYLHGTRHGSQDCGSRESLATSEMSAFHQPGPCEDPSCLTHGDYYDNLSLASPKWGDKPGVSPSIGLSVGSGWPSSPGSDPPLPKPCGDHPLNHRQLSLSSSRSSEGSLGGQNSGIGGRSSEKPTGLWSTASSQRVSPGLPSPNLENGAPAVGPVQPRTPSVSAPLALSCPRQGGLPRSNSGLGGEVSGVMSKPNVDPQPWFQDGPKSYLSSSAPSSSPAGLDGSQQGAVPGLGPKPGCTDLGTGPKLSPTSLVHPVMSTLPELSCKEGPLGWSSDGSLGSVLLDSPSSPRVRLPCQPLVPGPELRPSAAELKLEALTQRLEREMDAHPKADYFGACVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLEDHLFCHSCHVKRLEKRPSSTALHQHHF"},{"id":"SEQ_01158","a":"Q9HAZ2","g":"PRDM16","d":"Histone-lysine N-methyltransferase PRDM16","L":1276,"m":[{"c":"xxCxxCxxx[FY]xxxxxLx[RKQ]H(x){3,4}[HC]","u":"23-24","sp":"dispersed","x":"structured_like","cf":"high","why":"Ten 23-24 aa Cys2His2/Cys2HisCys-type repeats featuring invariant C3, C6, L16, and H19 anchors, conserved [FY]10 and [RKQ]18 positions, and a C-terminal [HC] separated by 3-4 residues, arranged in two separate multi-repeat arrays (seven N-terminal copies and three C-terminal copies separated by ~505 aa, mostly with 5-6 aa inter-repeat linkers within arrays).","i":[[230,253,"FRCDECDELFQSKLDLRRHKKYTC"],[281,303,"HECKDCERMFPNKYSLEQHMVIH"],[309,331,"YKCDQCPKAFNWKSNLIRHQMSH"],[337,360,"FECENCVKVFTDPSNLQRHIRSQH"],[366,388,"HACPDCGKTFATSSGLKQHKHIH"],[394,416,"FICEVCHKSYTQFSNLCRHKRMH"],[423,445,"IKCKDCGQMFSTTSSLNKHRRFC"],[951,973,"YTCRYCGKIFPRSANLTRHLRTH"],[979,1002,"YRCKYCDRSFSISSNLQRHVRNIH"],[1008,1030,"FKCHLCNRCFGQQTNLDRHLKKH"]]},{"c":"[AL]+PSPx[LF]","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 7-residue motifs within the central proline/serine-rich disordered region sharing an invariant PSP core flanked N-terminally by an aliphatic [AL] and basic (+) residue and C-terminally by a bulky hydrophobic [LF] anchor.","i":[[472,478,"AKPSPSL"],[856,862,"AKPSPFF"],[887,893,"LRPSPLL"]]}],"s":"MRSKARARKLAKSDGDVVNNMYEPNRDLLASHSAEDEAEDSAMSPIPVGPPSPFPTSEDFTPKEGSPYEAPVYIPEDIPIPADFELRESSIPGAGLGVWAKRKMEAGERLGPCVVVPRAAAKETDFGWEQILTDVEVSPQEGCITKISEDLGSEKFCVDANQAGAGSWLKYIRVACSCDDQNLTMCQISEQIYYKVIKDIEPGEELLVHVKEGVYPLGTVPPGLDEEPTFRCDECDELFQSKLDLRRHKKYTCGSVGAALYEGLAEELKPEGLGGGSGQAHECKDCERMFPNKYSLEQHMVIHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKRFECENCVKVFTDPSNLQRHIRSQHVGARAHACPDCGKTFATSSGLKQHKHIHSTVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHYTPGGIFAPGLPLTPSPMMDKAKPSPSLNHASLGFNEYFPSRPHPGSLPFSTAPPTFPALTPGFPGIFPPSLYPRPPLLPPTSLLKSPLNHTQDAKLPSPLGNPALPLVSAVSNSSQGTTAAAGPEEKFESRLEDSCVEKLKTRSSDMSDGSDFEDVNTTTGTDLDTTTGTGSDLDSDVDSDPDKDKGKGKSAEGQPKFGGGLAPPGAPNSVAEVPVFYSQHSFFPPPDEQLLTATGAAGDSIKAIASIAEKYFGPGFMGMQEKKLGSLPYHSAFPFQFLPNFPHSLYPFTDRALAHNLLVKAEPKSPRDALKVGGPSAECPFDLTTKPKDVKPILPMPKGPSAPASGEEQPLDLSIGSRARASQNGGGREPRKNHVYGERKLGAGEGLPQVCPARMPQQPPLHYAKPSPFFMDPIYSRVEKRKVTDPVGALKEKYLRPSPLLFHPQMSAIETMTEKLESFAAMKADSGSSLQPLPHHPFNFRSPPPTLSDPILRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCNRCFGQQTNLDRHLKKHEHENAPVSQHPGVLTNHLGTSASSPTSESDNHALLDEKEDSYFSEIRNFIANSEMNQASTRTEKRADMQIVDGSAQCPGLASEKQEDVEEEDDDDLEEDDEDSLAGKSQDDTVSPAPEPQAAYEDEEDEEPAASLAVGFDHTRRCAEDHEGGLLALEPMPTFGKGLDLRRAAEEAFEVKDVLNSTLDSEALKHTLCRQAKNQAYAMMLSLSEDTPLHTPSQGSLDAWLKVTGATSESGAFHPINHL"},{"id":"SEQ_01174","a":"Q96EK7","g":"FAM120B","d":"Constitutive coactivator of peroxisome proliferator-activated receptor gamma","L":910,"m":[{"c":"[TS][DG]xE[PS]+QEVPψ[CY]","u":12,"sp":"tandem","x":"disordered_like","cf":"high","why":"Large central tandem array of 15 highly conserved 12-aa disordered repeats anchored by [TS][DG] at positions 1-2, E at position 4, basic + at position 6, QEVPψ core, and [CY] at position 12 (with one 11-aa deletion unit TDPESRQEIMC between copies 13 and 14 and four more diverged 12-aa repeats trailing C-terminally).","i":[[333,344,"SDAESREEVPMC"],[345,356,"SDAESRQEVPMC"],[357,368,"TGPESRREVPVY"],[369,380,"TDSEPRQEVPMC"],[381,392,"SDPEPRQEVPTC"],[393,404,"TGPESRREVPMC"],[405,416,"SDPEPRQEVPMC"],[417,428,"TGPEARQEVPMY"],[429,440,"TDSEPRQEVPMY"],[441,452,"TDSEPRQEVPMY"],[453,464,"TGSEPRQEVPMY"],[465,476,"TGPESRQEVPMY"],[477,488,"TGPESRQEVLIR"],[500,511,"TGHESKQEVPIC"],[512,523,"TDPISKQEDSMC"]]}],"s":"MGVRGLQGFVGSTCPHICTVVNFKELAEHHRSKYPGCTPTIVVDAMCCLRYWYTPESWICGGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKNNREISRIFHYIKSHKEQPGRNMFFIPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGLQHNCLGILGEDTDYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGLCVADLPLLACLLGNDIIPEGMFESFRYKCLSSYTSVKENFDKKGNIILAVSDHISKVLYLYQGEKKLEEILPLGPNKALFYKGMASYLLPGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEINQKLPVATDFEFKLEALMCTNPEIKQEDPTNVGPEVKQQVTMVSDTEILKVARTHHVQAESYLVYNIMSSGEIECSNTLEDELDQALPSQAFIYRPIRQRVYSLLLEDCQDVTSTCLAVKEWFVYPGNPLRHPDLVRPLQMTIPGGTPSLKILWLNQEPEIQVRRLDTLLACFNLSSSREELQAVESPFQALCCLLIYLFVQVDTLCLEDLHAFIAQALCLQGKSTSQLVNLQPDYINPRAVQLGSLLVRGLTTLVLVNSACGFPWKTSDFMPWNVFDGKLFHQKYLQSEKGYAVEVLLEQNRSRLTKFHNLKAVVCKACMKENRRITGRAHWGSHHAGRWGRQGSSYHRTGSGYSRSSQGQPWRDQGPGSRQYEHDQWRRY"},{"id":"SEQ_01178","a":"P23769","g":"GATA2","d":"Endothelial transcription factor GATA-2","L":480,"m":[{"c":"CφNCxxTxTxLWRRxxoGxxψCNACGLY[HY]KψxxxNRPL","u":38,"sp":"dispersed","x":"structured_like","cf":"high","why":"Strongly conserved 2-copy 38-aa structured Cys4-type repeat separated by a 15-aa basic linker, sharing 24 identical anchor positions including CφNC, LWRR, G, CNACGLY[HY]Kψ, and C-terminal NRPL.","i":[[295,332,"CVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPL"],[349,386,"CANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPL"]]}],"s":"MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHNPWTVSPFSKTPLHPSAAGGPGGPLSVYPGAGGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKEVSPDPSTTGAASPASSSAGGSAARGEDKDGVKYQVSLTESMKMESGSPLRPGLATMGTQPATHHPIPTYPSYVPAAAHDYSSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGAECFEELSKCMQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMG"},{"id":"SEQ_01181","a":"Q6P1L5","g":"FAM117B","d":"Protein FAM117B","L":589,"m":[{"c":"[TG]SPTx[SAG][GTA]","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five dispersed 7-aa motifs clustered in the N-terminal disordered region (residues 9-129) sharing an invariant SPT core preceded by [TG] and followed by small [SAG][GTA] residues, with three copies conserving the stricter [TG]SPTR[SG][GA] consensus.","i":[[9,15,"GSPTPAG"],[52,58,"GSPTRSG"],[92,98,"TSPTRGG"],[105,111,"TSPTVAT"],[123,129,"TSPTRSA"]]}],"s":"MSQRVRRNGSPTPAGSLGGGAVATAGGPGSRLQPMRATVPFQLKQQQQQQHGSPTRSGGGGGGNNNGGCCGGASGPAGGGGGGGPRTASRSTSPTRGGGNAAARTSPTVATQTGASATSTRGTSPTRSAAPGARGSPPRPPPPPPLLGTVSSPSSSPTHLWTGEVSAAPPPARVRHRRRSPEQSRSSPEKRSPSAPVCKAGDKTRQPSSSPSSIIRRTSSLDTLAAPYLAGHWPRDSHGQAAPCMRDKATQTESAWAEEYSEKKKGSHKRSASWGSTDQLKEIAKLRQQLQRSKHSSRHHRDKERQSPFHGNHAAINQCQAPVPKSALIPVIPITKSTGSRFRNSVEGLNQEIEIIIKETGEKEEQLIPQDIPDGHRAPPPLVQRSSSTRSIDTQTPGGADRGSNNSSRSQSVSPTSFLTISNEGSEESPCSADDLLVDPRDKENGNNSPLPKYATSPKPNNSYMFKREPPEGCERVKVFEECSPKQLHEIPAFYCPDKNKVNFIPKSGSAFCLVSILKPLLPTPDLTLKGSGHSLTVTTGMTTTLLQPIAVASLSTNTEQDRVSRGTSTVMPSASLLPPPEPIEEAEG"},{"id":"SEQ_01185","a":"Q9NUG4","g":"CCM2L","d":"Cerebral cavernous malformations 2 protein-like","L":571,"m":[{"c":"[SG]GSWERR[QH]","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four strongly conserved 8-aa repeats within the central Gly-rich disordered linker sharing an invariant GSWERR core flanked by [SG] at position 1 and alternating Q/H at position 8, arranged as two closely spaced pairs.","i":[[234,241,"SGSWERRQ"],[244,251,"SGSWERRH"],[264,271,"GGSWERRQ"],[277,284,"GGSWERRH"]]}],"s":"MEYEVKKGKKGFVSPIRRLVFPKAGRRAACRSSVSRRPLHSMPLYPPDYLIDPQILLCDYLEKEVKFLGHLTWVTSSLNPSSRDELLQLLDTARQLKELPLKTTAEQDSILSLSARCLLLTWRDNEELILRIPTHEIAAASYLQDDALHLLVLKTGLGVDPVPAGVDASPGGAGRDPGPPGGAPEKRRVGTAERRHTICSLDWRMGWGGGAAEARAGGGGGGSLERQRAGARASGSWERRQTFSGSWERRHGGGGGGGGAGKPGGSWERRQAGSGGGGSWERRHPGPNPLDPQDPSPDAYCNLVILAVANRDAAEESCALICQVFQIIYGDQSIECVDRAGYHYTSTPERPWLCSRSESCHTDGTYAYDADFSCCSSFNGSQDTFEACYSGTSTPSFHGSHCSGSDHSSLGLEQLQDYMVTLRSKLGPLEIQQFAMLLREYRLGLPIQDYCTGLLKLYGDRRKFLLLGMRPFIPDQDIGYFEGFLEGVGIREGGILTDSFGRIKRSMSSTSASAVRSYDGAAQRPEAQAFHRLLADITHDIEALAPDDDDDDEDEPRGSRGGSDAAEDNYL"},{"id":"SEQ_01192","a":"Q96M83","g":"CCDC7","d":"Coiled-coil domain-containing protein 7","L":1385,"m":[{"c":"ETDxExLxxAxG+xψψxxxφxxQ[LS]+(x){0,1}[ST]Hx","u":"28-29","sp":"tandem","x":"structured_like","cf":"high","why":"Nine head-to-tail tandem 28-29 aa repeats (residues 1005-1257) anchored by an N-terminal ETD triad, central G+xψψ hydrophobic core, and C-terminal Q[LS]+[ST]Hx signature.","i":[[1005,1032,"ETDIESLRGALGRRLLNDEFKTQSKSFP"],[1033,1060,"GPDIEQLTDAFGRDILKDEFKTRSKSLP"],[1061,1089,"ETDERLHSTTERGTINDAIKTQLKRKSYP"],[1090,1117,"ETVLKHLKGVNGKDIIKHLINIQSKSHG"],[1118,1145,"ETDKEHLADDTGRGIIKGSINAQLKGHQ"],[1146,1173,"KTDKNFFAYATGRGLMKESTTTQLKSHP"],[1174,1201,"ETDKEFLADAIGRGIIIGPITTQLKSHR"],[1202,1229,"ETDKELLKDAIGRDIIKGPISAQLKSHQ"],[1230,1257,"ETDVEPLTNAIGSSKTIGEIKTQLRTHY"]]},{"c":"ψPx-N[LV]ψφx[HR]Q-Sx[ST]KxxψQxxx[QK]","u":24,"sp":"dispersed","x":"mixed","cf":"high","why":"Ten ungapped 24-aa repeats across residues 605-966 separated by 7-25 aa polar linkers (quasi-periodic ~12-14 aa in the central copies), conserved at P2, N[LV]ψφ hydrophobic patch, [HR]Q-Sx[ST]K core, and ψQ.","i":[[605,628,"VPDENLMVENKDSVTKVQIEQMKQ"],[645,668,"LPEDMVLVSRIQSETKNLKATRNE"],[676,699,"VPEENLMLEQDTKSKTEVEVKKQK"],[712,735,"VPNERLVVEHQESLSKTKLQIKKQ"],[749,772,"EPNENLILRHQDSMSKSEMQVKEQ"],[786,809,"EPGKNLVLEHQDSVSKLEMQIEKT"],[824,847,"ESGENPMLKHQDSVSKIQVQLEIQ"],[857,880,"IPDKNSMFVHQDSVSKLQMQEKKK"],[894,917,"VPNENVISVHQDSKSKLQMQEKKQ"],[943,966,"LPEEKVLLSRSESQTKKLQAKVTS"]]}],"s":"MKPVKHLLTTSNKSANVPALTTKKGLHNLPLSPELKEKHNAKLIHDKIEPMVLRSPPTGESILRYALPIPSSKTKNLLPEDEMIGKIIKHLKMVVSTLEETYGHCDQNGEEPFVKHEHEELSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNIPLEKETRKSLVSDSGGQRTSDKIQEYPQITAQSGRLIEKSSEKKRSSPAISDLSQILKSQDESAFLESSNEVSVAENQSYKSPSETHDKSLTTVSSSKEVQDSLSVGTLAQKNETVISPFILPPVLTESKKADVSEEQLQKMTEEQTYQAAEKSQADSEVPDENLMVENKDSVTKVQIEQMKQRTSSMERHEETLTTPQLPEDMVLVSRIQSETKNLKATRNESFHSHNDVPEENLMLEQDTKSKTEVEVKKQKSFQDNQLSTHNEVPNERLVVEHQESLSKTKLQIKKQETSTEQPLTTPDKEPNENLILRHQDSMSKSEMQVKEQRTLKGQRIITHDEEPGKNLVLEHQDSVSKLEMQIEKTKKLPREKRHSTHDEESGENPMLKHQDSVSKIQVQLEIQETSEGEGRSIPDKNSMFVHQDSVSKLQMQEKKKITPGRERRNTRIVVPNENVISVHQDSKSKLQMQEKKQINSGVERHKTFPLEIKKKDISLEHLLPEEKVLLSRSESQTKKLQAKVTSRKIKNEAASELPDTAENLPAMYPSISDLIIQFDLNKVVETDIESLRGALGRRLLNDEFKTQSKSFPGPDIEQLTDAFGRDILKDEFKTRSKSLPETDERLHSTTERGTINDAIKTQLKRKSYPETVLKHLKGVNGKDIIKHLINIQSKSHGETDKEHLADDTGRGIIKGSINAQLKGHQKTDKNFFAYATGRGLMKESTTTQLKSHPETDKEFLADAIGRGIIIGPITTQLKSHRETDKELLKDAIGRDIIKGPISAQLKSHQETDVEPLTNAIGSSKTIGEIKTQLRTHYDVNLFKNKDMSVQRQEGIFTRSITPSKFPTKVINLSPFENKEETYEYSSPYVTAPSKAIYRTYRAGPSFSKDIHLPLLNQLPSGHSKVVTLSQKTIEFTLPTVTNTVGKPTYKVLHAAARKSVPHPYF"},{"id":"SEQ_01203","a":"Q8IYL3","g":"C1orf174","d":"UPF0688 protein C1orf174","L":243,"m":[{"c":"[SA]A[SL]LP","u":5,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three clustered 5-aa motifs within a 41-residue disordered segment (residues 80-120, separated by 15-aa and 11-aa linkers) sharing fixed A, L, and P anchors and constrained [SA]/[SL] positions.","i":[[80,84,"SASLP"],[100,104,"SALLP"],[116,120,"AASLP"]]}],"s":"MRSRKLTGAVRSSARLKARSCSAARLASAQEVAGSTSAKTACLTSSSHKATDTRTSKKFKCDKGHLVKSELQKLVPKNDSASLPKVTPETPCENEFAEGSALLPGSEAGVSVQQGAASLPLGGCRVVSDSRLAKTRDGLSVPKHSAGSGAEESNSSSTVQKQNEPGLQTEDVQKPPLQMDNSVFLDDDSNQPMPVSRFFGNVELMQDLPPASSSCPSMSRREFRKMHFRAKDDDDDDDDDAEM"},{"id":"SEQ_01205","a":"Q5SXM2","g":"SNAPC4","d":"snRNA-activating protein complex subunit 4","L":1469,"m":[{"c":"[KN]+[GKQ]xWxx[EK]E-xxLxxφφ[AQE][AEK][HMY](x){4,7}Ωx+Ix[ESY][EY]ψ(x){2,3}R[SD]xxQ[CL][ILR]x+Ω(x){6,9}L","u":"52-55","sp":"tandem","x":"structured_like","cf":"high","why":"Four contiguous head-to-tail 52-55 aa helical repeats (preceded by a divergent N-terminal partial copy) anchored by invariant W, E, L, I, R, Q, and terminal L positions plus conserved aromatic (Ω), basic (+), acidic (-), and hydrophobic (φ/ψ) cores.","i":[[293,344,"NKQEWSREEEERLQAIAAAHGHLEWQKIAEELGTSRSAFQCLQKFQQHNKAL"],[345,399,"KRKEWTEEEDRMLTQLVQEMRVGSHIPYRRIVYYMEGRDSMQLIYRWTKSLDPGL"],[400,451,"KKGYWAPEEDAKLLQAVAKYGEQDWFKIREEVPGRSDAQCRDRYLRRLHFSL"],[452,505,"KKGRWNLKEEEQLIELIEKYGVGHWAKIASELPHRSGSQCLSKWKIMMGKKQGL"]]},{"c":"LEK[LP]PL[PR]QPGPEKGALD","u":17,"sp":"tandem","x":"disordered_like","cf":"high","why":"Head-to-tail 17-residue tandem duplication within the proline/glycine-rich C-terminal disordered region sharing 15/17 identical positions, including an invariant 10-residue QPGPEKGALD C-terminal block.","i":[[1237,1253,"LEKLPLRQPGPEKGALD"],[1254,1270,"LEKPPLPQPGPEKGALD"]]}],"s":"MDVDAEREKITQEIKELERILDPGSSGSHVEISESSLESDSEADSLPSEDLDPADPPISEEERWGEASNDEDDPKDKTLPEDPETCLQLNMVYQEVIQEKLAEANLLLAQNREQQEELMRDLAGSKGTKVKDGKSLPPSTYMGHFMKPYFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKWKNWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSKVSSELERQALEKQGREAEKEIQDINQLPEEALLGNRLDSHDWEKISNINFEGSRSAEEIRKFWQNSEHPSINKQEWSREEEERLQAIAAAHGHLEWQKIAEELGTSRSAFQCLQKFQQHNKALKRKEWTEEEDRMLTQLVQEMRVGSHIPYRRIVYYMEGRDSMQLIYRWTKSLDPGLKKGYWAPEEDAKLLQAVAKYGEQDWFKIREEVPGRSDAQCRDRYLRRLHFSLKKGRWNLKEEEQLIELIEKYGVGHWAKIASELPHRSGSQCLSKWKIMMGKKQGLRRRRRRARHSVRWSSTSSSGSSSGSSGGSSSSSSSSSEEDEPEQAQAGEGDRALLSPQYMVPDMDLWVPARQSTSQPWRGGAGAWLGGPAASLSPPKGSSASQGGSKEASTTAAAPGEETSPVQVPARAHGPVPRSAQASHSADTRPAGAEKQALEGGRRLLTVPVETVLRVLRANTAARSCTQKEQLRQPPLPTSSPGVSSGDSVARSHVQWLRHRATQSGQRRWRHALHRRLLNRRLLLAVTPWVGDVVVPCTQASQRPAVVQTQADGLREQLQQARLASTPVFTLFTQLFHIDTAGCLEVVRERKALPPRLPQAGARDPPVHLLQASSSAQSTPGHLFPNVPAQEASKSASHKGSRRLASSRVERTLPQASLLASTGPRPKPKTVSELLQEKRLQEARAREATRGPVVLPSQLLVSSSVILQPPLPHTPHGRPAPGPTVLNVPLSGPGAPAAAKPGTSGSWQEAGTSAKDKRLSTMQALPLAPVFSEAEGTAPAASQAPALGPGQISVSCPESGLGQSQAPAASRKQGLPEAPPFLPAAPSPTPLPVQPLSLTHIGGPHVATSVPLPVTWVLTAQGLLPVPVPAVVSLPRPAGTPGPAGLLATLLPPLTETRAAQGPRAPALSSSWQPPANMNREPEPSCRTDTPAPPTHALSQSPAEADGSVAFVPGEAQVAREIPEPRTSSHADPPEAEPPWSGRLPAFGGVIPATEPRGTPGSPSGTQEPRGPLGLEKLPLRQPGPEKGALDLEKPPLPQPGPEKGALDLGLLSQEGEAATQQWLGGQRGVRVPLLGSRLPYQPPALCSLRALSGLLLHKKALEHKATSLVVGGEAERPAGALQASLGLVRGQLQDNPAYLLLRARFLAAFTLPALLATLAPQGVRTTLSVPSRVGSESEDEDLLSELELADRDGQPGCTTATCPIQGAPDSGKCSASSCLDTSNDPDDLDVLRTRHARHTRKRRRLV"},{"id":"SEQ_01217","a":"Q9UFD9","g":"RIMBP3","d":"RIMS-binding protein 3A","L":1639,"m":[{"c":"+ψφψAxx[DN]Y[DN]P(x){10,12}[ER]Lxφx[AK][GR][DQ]φψxψΩGx[MQ]Dxx[GD]FYx[GS]E[LC](x){3,4}[RV]G[LN]ψPxxφψ","u":"60-61","sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed 60-61 aa structured domain repeats (one central and two C-terminal) sharing conserved sequence architecture across four core segments: an N-terminal +ψφψAxx[DN]Y[DN]P motif, a central [ER]Lxφ...ψΩGx[MQ]D strand, a [GD]FYx[GS]E[LC] motif, and a C-terminal [RV]G[LN]ψPxxφψ signature separated by two short variable loops.","i":[[835,894,"KIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFV"],[1455,1515,"RVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNIPGRLV"],[1572,1631,"KIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHLL"]]}],"s":"MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQAENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARKLQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVEQIPDSYIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGVVDRGLCQMVRVGSKTEVATEILDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRARVEVRLPRDLLQVYWGTMSSTVTFDTLLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVADATAGSTLLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYTCGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNLGSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCSQHMGTSKSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLKEEQEALCLDLWGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPRGGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGNLPSVAHLEDFQGLTIPQGSSLVLQGNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHLLDHMSLHGH"},{"id":"SEQ_01221","a":"Q8N2N9","g":"ANKRD36B","d":"Ankyrin repeat domain-containing protein 36B","L":1353,"m":[{"c":"[GR]TVS[SP]QKQPAxK[AVT]TSD[EK][KE]DSφ[SL]NIA[TR]E[IK]K-GxxS","u":34,"sp":"tandem","x":"disordered_like","cf":"high","why":"Head-to-tail tandem array of 14 highly conserved 34-residue polar/charged-rich units (residues 253-728) anchored by invariant K12, S20, N23, conserved [GR]TVS[SP]QKQPA N-terminal motifs, and a central DSφ[SL]NIA[TR]E[IK]K-G core.","i":[[253,286,"NPVSPQKQRAEKATSDDKDSVSNIATEIKEGPIS"],[287,320,"GTVSSQKQPAEKATSDEKDSVSNIATEIKEGQQS"],[321,354,"GTVSPQKQSAQKVIFKKKVSLLNIATRIMGGGKS"],[355,388,"GTVSSQKQPASKTASDKTDSALNTATEIKDGLQC"],[389,422,"GTVSSQKQQALKATTDEEGSVSNIATEIKDGEKS"],[423,456,"GTVSSQKKPALKATSDEKDSFSNITREKKDGEIS"],[457,490,"RTVSSQKPPALKATSVKEDSVLNIAREKKDGEKS"],[491,524,"RTVSFEQPPGLKATRDEKDSLLNIARGKKDGEKT"],[525,558,"RRVSSHKQPSLKATSDKEDSVPNMATETKDEQIS"],[559,592,"GTVSCQKQPALKATSDKKDSVSNIPTEIKDGQQS"],[593,626,"GTVSSQKQPAWKATSVKKDSVSNIATEIKDGQIR"],[627,660,"GTVSSQRRPALKTTGDEKDSVSNIAREIKDGEKS"],[661,694,"GTVSPQKQSAQKVIFKKKVSLLNIATRITGGGKS"],[695,728,"GTEYPENLRTLKATIENKDSVLNTATKMKEVQTS"]]},{"c":"[EDG][RY]o[AP]L[HIL]xA[VC]xxxxxx[MCI]φxxL[LV]xxxx[EDN]xxxx[DS]xx","u":33,"sp":"tandem","x":"structured_like","cf":"high","why":"Five contiguous 33-residue structured tandem repeats in the N-terminal domain (residues 53-217) defined by conserved o[AP]L[HIL]xA[VC] and φxxL[LV] hydrophobic helix-packing cores separated by polar/acidic turn positions.","i":[[53,85,"ERTALHLACATGQPEMVHLLVSRRCELNLCDRE"],[86,118,"DRTPLIKAVQLRQEACATLLLQNGADPNITDVF"],[119,151,"GRTALHYAVYNEDTSMIEKLLSHGTNIEECSKN"],[152,184,"EYQPLLLAVSRRKVKMVEFLLKKKANVNAIDYL"],[185,217,"GRSALILAVTLGEKDIVILLLQHNIDVFSRDVY"]]}],"s":"MERLCSDGFAFPHYYIKPYHLKRIHRAVLRGNLEKLKYLLLTYYDANKRDRKERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQLRQEACATLLLQNGADPNITDVFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKNEYQPLLLAVSRRKVKMVEFLLKKKANVNAIDYLGRSALILAVTLGEKDIVILLLQHNIDVFSRDVYGKLAEDYASEAENRVIFDLIYEYKRKRYEDLPINSNPVSPQKQRAEKATSDDKDSVSNIATEIKEGPISGTVSSQKQPAEKATSDEKDSVSNIATEIKEGQQSGTVSPQKQSAQKVIFKKKVSLLNIATRIMGGGKSGTVSSQKQPASKTASDKTDSALNTATEIKDGLQCGTVSSQKQQALKATTDEEGSVSNIATEIKDGEKSGTVSSQKKPALKATSDEKDSFSNITREKKDGEISRTVSSQKPPALKATSVKEDSVLNIAREKKDGEKSRTVSFEQPPGLKATRDEKDSLLNIARGKKDGEKTRRVSSHKQPSLKATSDKEDSVPNMATETKDEQISGTVSCQKQPALKATSDKKDSVSNIPTEIKDGQQSGTVSSQKQPAWKATSVKKDSVSNIATEIKDGQIRGTVSSQRRPALKTTGDEKDSVSNIAREIKDGEKSGTVSPQKQSAQKVIFKKKVSLLNIATRITGGGKSGTEYPENLRTLKATIENKDSVLNTATKMKEVQTSTPAEQDLEMASEGEQKRLEEYENNQPQVKNQIHSRDDLDDIIQSSQTVSEDGDSLCCNCKNVILLIDQHEMKCKDCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQNLEKKYLKDFEIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYRCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAEREVAVRQLQQKRDDVLNKGSATKALLDASSRHCTYLENGMQDSRKKLDQMRSQFQEIQDQLTATIRCTKEMEGDTQKLEVEHVMMRKIIKKQDDQIERLEKILQHSSLMLQVFES"},{"id":"SEQ_01224","a":"Q2V2M9","g":"FHOD3","d":"FH1/FH2 domain-containing protein 3","L":1422,"m":[{"c":"PPPP[TLV][FLP]xx[LIP]","u":9,"sp":"tandem","x":"disordered_like","cf":"high","why":"Four tandem copies (0-3 aa linkers) in the central disordered region share a conserved PPPP core immediately flanked by constrained aliphatic/polar ([TLV]) and hydrophobic/Pro ([FLP]) anchors at positions 5-6 and a C-terminal [LIP] position (L/I in three of four copies).","i":[[832,840,"PPPPTFLGL"],[844,852,"PPPPLLDSI"],[853,861,"PPPPVPGNL"],[864,872,"PPPPVFNAP"]]}],"s":"MATLACRVQFLDDTDPFNSTNFPEPSRPPLFTFREDLALGTQLAGVHRLLQAPHKLDDCTLQLSHNGAYLDLEATLAEQRDELEGFQDDAGRGKKHSIILRTQLSVRVHACIEKLYNSSGRDLRRALFSLKQIFQDDKDLVHEFVVAEGLTCLIKVGAEADQNYQNYILRALGQIMLYVDGMNGVINRNETIQWLYTLIGSKFRLVVKTALKLLLVFVEYSESNAPLLIQAVTAVDTKRGVKPWSNIMEILEEKDGVDTELLVYAMTLVNKTLSGLPDQDTFYDVVDCLEELGIAAVSQRHLNKKGTDLDLVEQLNIYEVALRHEDGDETTEPPPSGCRDRRRASVCSSGGGEHRGLDRRRSRRHSVQSIKSTLSAPTSPCSQSAPSFKPNQVRDLREKYSNFGNNSYHSSRPSSGSSVPTTPTSSVSPPQEARLERSSPSGLLTSSFRQHQESLAAERERRRQEREERLQRIEREERNKFRYKYLEQLAAEEHEKELRSRSVSRGRADLSLDLTSPAAPACLAPLSHSPSSSDSQEALTVSASSPGTPHHPQASAGDPEPESEAEPEAEAGAGQVADEAGQDIASAHEGAETEVEQALEQEPEERASLSEKERQNEGVNERDNCSASSVSSSSSTLEREEKEDKLSRDRTTGLWPAGVQDAGVNGQCGDILTNKRFMLDMLYAHNRKSPDDEEKGDGEAGRTQQEAEAVASLATRISTLQANSQTQDESVRRVDVGCLDNRGSVKAFAEKFNSGDLGRGSISPDAEPNDKVPETAPVQPKTESDYIWDQLMANPRELRIQDMDFTDLGEEDDIDVLDVDLGHREAPGPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPVFNAPQGLGWSQVPRGQPTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKVDTSRLEHLFESKSKELSVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRTIKIAILNFDEYALNKEGIEKILTMIPTDEEKQKIQEAQLANPEIPLGSAEQFLLTLSSISELSARLHLWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKAFELSYLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDNLCQMERRCKASWDHLKAIAKHEMKPVLKQRMSEFLKDCAERIIILKIVHRRIINRFHSFLLFMGHPPYAIREVNINKFCRIISEFALEYRTTRERVLQQKQKRANHRERNKTRGKMITDSGKFSGSSPAPPSQPQGLSYAEDAAEHENMKAVLKTSSPSVEDATPALGVRTRSRASRGSTSSWTMGTDDSPNVTDDAADEIMDRIVKSATQVPSQRVVPRERKRSRANRKSLRRTLKSGLTPEEARALGLVGTSELQL"},{"id":"SEQ_01229","a":"Q9NZM3","g":"ITSN2","d":"Intersectin-2","L":1697,"m":[{"c":"xxxxAφ(x){7,10}ψo[FL]xx[GH][DEQ]xIx[VI](x){6,9}W[WL]xG[SE]φ(x){4,9}G[WIL]FPx[NS][YH]V[EK]","u":"52-55","sp":"dispersed","x":"structured_like","cf":"high","why":"Five dispersed ~52-55 aa structured domain repeats in the central-C-terminal region (residues 761-1183) separated by 15-85 aa linkers, anchored by invariant Aφ, ψo[FL]xx[GH][DEQ]xIx[VI], W[WL]xG[SE]φ, and C-terminal G[WIL]FPx[NS][YH]V[EK] motifs.","i":[[760,814,"VNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE"],[901,952,"LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVK"],[984,1035,"EEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVK"],[1059,1113,"QVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVK"],[1130,1182,"CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK"]]},{"c":"WAψxxxxRxK[HY](x){11,12}GYψ[ST]GxQARNφφLQSxLxxxxLAxIWxL[SA]Dψ[ND]xDGxψxx[QE]EFxψAM[KH]LxxψxxxGQxLPψxLPP(x){3,4}PPxF","u":94,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two highly conserved 94 aa N-terminal structured repeats separated by a 128 aa Pro/Ser/Thr-rich disordered linker, sharing WAψxxxxRxK[HY], a 64 aa gapless core (GYψ[ST]GxQARN...IW...DG...EFxψAM...GQxLPψxLPP), and a C-terminal PPxF motif.","i":[[16,109,"WAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMF"],[238,331,"WAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSF"]]}],"s":"MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGSMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKKREKAYQARSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTGEVWVRFDLQLFEQKTLL"},{"id":"SEQ_01233","a":"Q7Z7G8","g":"VPS13B","d":"Intermembrane lipid transfer protein VPS13B","L":4022,"m":[{"c":"[ST]+G[PT]x[AST][FS]ψxxψ","u":11,"sp":"tandem","x":"mixed","cf":"medium","why":"Three head-to-tail 11-residue amphipathic repeats in the C-terminal region (residues 3683-3715) anchored by an N-terminal [ST]+G turn/cap motif and conserved large aliphatic (ψ) positions at +8 and +11 corresponding to a 3-turn (3-11) amphipathic helical register.","i":[[3683,3693,"TRGPGAFVSGV"],[3694,3704,"SRGTTSFVKHI"],[3705,3715,"SKGTLTSITNL"]]}],"s":"MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSGHIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQDDHESCGSNSTNRSTAESTKSSIKPRRMQQAAPTDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAECYTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRTRLHFTYENLNSKMPSVIKIHTLVESLKLSITDQQLPMFIRIMQLGIALYYGEIGNFKEGEIEDLTCHNKDMLGNITGSEDETRIDMQYPAQHKGQELYSQQDEEQPQGWVSWAWSFVPAIVSYDDGEEDFVGNDPASTMHQQKAQTLKDPIVSIGFYCTKATVTFKLTEMQVESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFVGCRAMCLKGIMGVKDFEENMNRSETEACFFICGDNLSTKGFTYLTNSLFDYRSPENNGTRAEFILDSTHHKETYTEIAGMQRFGAFYMDYLYTMENTSGKGSTNQQDFSSGKSEDLGTVQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPEEVALLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRPLPSIRILVDKINLEHSVPMYAEQLVHVVSSLTQPSDNLLHYCYVHCYLKIFGFQAGLTSLDCSGSYCLPVPVIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLLLQAIYQSWSHLGNVSSSAVIEALINEIFLSIGVKSKNPLPTLEGSIQNVELKYCSTSLVKCASGTMGSIKICAKAPVDSGKEKLIPLLQGPSDTKDLHSTKWLNESRKPESLLAPDLMAFTIQVPQYIDYCHNSGAVLLCSIQGLAVNIDPILYTWLIYQPQKRTSRHMQQQPVVAVPLVMPVCRRKEDEVSIGSAPLAKQQSYQASEYASSPVKTKTVTESRPLSVPVKAMLNISESCRSPEERMKEFIGIVWNAVKHLTLQLEVQSCCVFIPNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISAGHKYMEPLQEIPFVIPRPILEEGDAFPWTISLHNFSIYTLLGKQVTLCLVEPMGCTSTLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELTDIMNKVWNKIQKRGNLNLSPTSPETMAGPVPTSPVRSSIGTAPPDTSTCSPSADIGTTTEGDSIQAGEESPFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKITIKLFAPDPENKGTEVCMVSELEDLSASIDVQDVYTKVKCKIESFNIDHYRSSLGEECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFSNCSGFFPSTTTKLLDGTHQQHGFLSLTYTKAVTKNVRHKLTSRNERRSFHKLSEGLMDGSPHFLHEILLSAQAFDIVLYFPLLNAIASIFQAKLPKTQKEKRKSPGQPMRTHTLTSRNLPLIYVNTSVIRIFIPKTEEMQPTVEANQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRDPGSEIEDRQYQIDLQSINIGTAQWHQLKPEKESVSGGVVTETERNSQNPALEWNMASSIRRHQERRAILTPVLTDFSVRITGAPAVIFTKVVSPENLHTEEILVCGHSLEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKAAEISKQEQKKVDIFDGGMAETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSRQSSIVKNLNFIPFDIFITASRISLMTYSCMALSKSKSQEQKNNEKTDKSSLNLPEVDSDVAKPNQACISTVTAEDLLRSSISFPSGKKIGVLSLESLHASTRSSARQALGITIVRQPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIFDAVLKGVASDYKCIDPGKTLPEALDYCTVWLQTVPGEIDSKSGIPPSFITLQIKDFLNGPADVNLDISKPLKANLSFTKLDQINLFLKKIKNAHSLAHSEETSAMSNTMVNKDDLPVSKYYRGKLSKPKIHGDGVQKISAQENMWRAVSCFQKISVQTTQIVISMETVPHTSKPCLLASLSNLNGSLSVKATQKVPGIILGSSFLLSINDFLLKTSLKERSRILIGPCCATANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVFWGQEHLNCLVLLHELLNGYLNEEGNFEVQVSEPVPQMSSPVEKNQTFKSEQSSDDLRTGLFQYVQDAESLKLPGVYEVLFYNETEDCPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQVPCSLEYWDELQKVFVAFREFNLSESKVCELQLPDINLVNDQKKLVSSDLWRIVLNSSQNGADDQSSASESGSQSTCDPLVTPTALAACTRVDSCFTPWFVPSLCVSFQFAHLEFHLCHHLDQLGTAAPQYLQPFVSDRNMPSELEYMIVSFREPHMYLRQWNNGSVCQEIQFLAQADCKLLECRNVTMQSVVKPFSIFGQMAVSSDVVEKLLDCTVIVDSVFVNLGQHVVHSLNTAIQAWQQNKCPEVEELVFSHFVICNDTQETLRFGQVDTDENILLASLHSHQYSWRSHKSPQLLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYRGRTASLIIKVQQLNGVQKQIIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENNELTELCVKAKGDEDWSRDVCLESKAPEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFSPLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLVHHLTFQAREEYDPSDCAVPISTSLIKQIATKVHPGGTVNQILDEFYGPEKSLQPIWPYNKKDSDRNEQLSQWDSPMRVKLSIWKPYVRTLLIELLPWALLINESKWDLWLFEGEKIVLQVPAGKIIIPPNFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDTEIRLGAFPGHQKLCQFCISSMVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVCNPHSGKEYFRVPDSATFSICPGGEQPAMKSSSLPCWDLMPDISQSVLDASLLQKQIMLGFSPAPGADSSQCWSLPAIVRPEFPRQSVAVPLGNFRENGFCTRAIVLTYQEHLGVTYLTLSEDPSPRVIIHNRCPVKMLIKENIKDIPKFEVYCKKIPSECSIHHELYHQISSYPDCKTKDLLPSLLLRVEPLDEVTTEWSDAIDINSQGTQVVFLTGFGYVYVDVVHQCGTVFITVAPEGKAGPILTNTNRAPEKIVTFKMFITQLSLAVFDDLTHHKASAELLRLTLDNIFLCVAPGAGPLPGEEPVAALFELYCVEICCGDLQLDNQLYNKSNFHFAVLVCQGEKAEPIQCSKMQSLLISNKELEEYKEKCFIKLCITLNEGKSILCDINEFSFELKPARLYVEDTFVYYIKTLFDTYLPNSRLAGHSTHLSGGKQVLPMQVTQHARALVNPVKLRKLVIQPVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFTTARQLVHALAMHYAAGALFRAGWVVGSLDILGSPASLVRSIGNGVADFFRLPYEGLTRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQLPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGIMGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRHQPSDLHADQAPNSHVKYVWKMLQSLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPVTEIDCAQDSKQNNLLTVQLKQPRVACDVEVDGVRERLSEQQYNRLVDYITKTSCHLAPSCSSMQIPCPVVAAEPPPSTVKTYHYLVDPHFAQVFLSKFTMVKNKALRKGFP"},{"id":"SEQ_01234","a":"Q9Y2H5","g":"PLEKHA6","d":"Pleckstrin homology domain-containing family A member 6","L":1048,"m":[{"c":"[PS][PA]YPExxR","u":8,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 8-residue motifs in disordered linker regions share an invariant YPE core and +3 R anchor flanked N-terminally by [PS][PA], capturing all three YPE occurrences in the 1048-residue protein.","i":[[251,258,"SPYPEGPR"],[510,517,"PPYPEVFR"],[579,586,"PAYPEKLR"]]}],"s":"MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVAFGKRSHSMKRNPNAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPDSENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAERRPERPEVKKEPPVKANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRPGSTAFPSQDGETGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRFYPVSRRVPEYYGPYSSQYPDDYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGGGPAYQLREWKEPASYGRQDATVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSPSQGSYSRARIYSPVRSPSARFERLPPRSEDIYADPAAYVMRRSISSPKVPPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALMGTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVSALHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSATYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGSNEPKANYEQSKKDPHQTLPLDTPRDISLVPTRQEVEAEKQAALNKVGVVPPRTKSPTDDEVTPSAVVRRNASGLTNGLSSQERPKSAVFPGEGKVKMSVEEQIDRMRRHQSGSMREKRRSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISNLEAALRAEEPGGHAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQCATPSPPTSPASPAPPANPLSSESPRGADSSYTMRV"},{"id":"SEQ_01241","a":"Q07666","g":"KHDRBS1","d":"KH domain-containing, RNA-binding, signal transduction-associated protein 1","L":443,"m":[{"c":"xx[PVT]RG","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Eight 5-residue repeats across a proline/glycine-rich region anchored by invariant C-terminal RG and a preceding [PVT] position, including a contiguous four-copy tandem core (GPPRG-ALVRG-TPVRG-AITRG) flanked by four copies across short proline-rich linkers.","i":[[286,290,"VPVRG"],[299,303,"PVPRG"],[307,311,"GPPRG"],[312,316,"ALVRG"],[317,321,"TPVRG"],[322,326,"AITRG"],[328,332,"TVTRG"],[337,341,"PTVRG"]]},{"c":"[DEQ][ST]YExY[EG]","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 7-residue tyrosine-rich motifs in the C-terminal disordered tail share invariant Y3, E4, and Y6 anchors with conserved acidic/polar [DEQ]1, hydroxyl [ST]2, and [EG]7 flanking positions.","i":[[364,370,"ETYEEYG"],[378,384,"QSYEGYE"],[406,412,"DSYEAYG"]]}],"s":"MQRRDDPAARMSRSSGRSGSMDPSGAHPSVRQTPSRQPPLPHRSRGGGGGSRGGARASPATQPPPLLPPSATGPDATVGGPAPTPLLPPSATASVKMEPENKYLPELMAEKDSLDPSFTHAMQLLTAEIEKIQKGDSKKDDEENYLDLFSHKNMKLKERVLIPVKQYPKFNFVGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEELRKGGDPKYAHLNMDLHVFIEVFGPPCEAYALMAHAMEEVKKFLVPDMMDDICQEQFLELSYLNGVPEPSRGRGVPVRGRGAAPPPPPVPRGRGVGPPRGALVRGTPVRGAITRGATVTRGVPPPPTVRGAPAPRARTAGIQRIPLPPPPAPETYEEYGYDDTYAEQSYEGYEGYYSQSQGDSEYYDYGHGEVQDSYEAYGQDDWNGTRPSLKAPPARPVKGAYREHPYGRY"},{"id":"SEQ_01256","a":"Q01538","g":"MYT1","d":"Myelin transcription factor 1","L":1121,"m":[{"c":"CP[TV]PGC[DTV]GxGHφx[GS]x[YFR]xxHRS[LA][SQ][GS]CP","u":26,"sp":"dispersed","x":"structured_like","cf":"high","why":"Seven strongly conserved 26-aa Cys/His-anchored repeats featuring invariant CPxPGCGxGH and HRSxxCP cores (including an identical pair at residues 800-825 and 844-869), distributed across an N-terminal copy, a central 2-copy cluster, and a C-terminal 4-copy cluster.","i":[[30,55,"CPTPGCTGSGHVRGKYSRHRSLQSCP"],[442,467,"CPTPGCDGTGHVTGLYPHHRSLSGCP"],[486,511,"CPTPGCTGQGHVNSNRNTHRSLSGCP"],[800,825,"CPTPGCDGSGHITGNYASHRSLSGCP"],[844,869,"CPTPGCDGSGHITGNYASHRSLSGCP"],[893,918,"CPVPGCVGLGHISGKYASHRSASGCP"],[946,971,"CPTPGCDGSGHANGSFLTHRSLSGCP"]]}],"s":"MSLENEDKRARTRSKALRGPPETTAADLSCPTPGCTGSGHVRGKYSRHRSLQSCPLAKKRKLEGAEAEHLVSKRKSHPLKLALDEGYGVDSDGSEDTEVKDASVSDESEGTLEGAEAETSGQDEIHRPETAEGRSPVKSHFGSNPIGSATASSKGSYSSYQGIIATSLLNLGQIAEETLVEEDLGQAAKPGPGIVHLLQEAAEGAASEEGEKGLFIQPEDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSHTSAQKAPELRGPESPSPKPEYSVIVEVRSDDDKDEDTHSRKSTVTDESEMQDMMTRGNLGLLEQAIALKAEQVRTVCEPGCPPAEQSQLGLGEPGKAAKPLDTVRKSYYSKDPSRAEKREIKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRIPPEILAMHENVLKCPTPGCTGQGHVNSNRNTHRSLSGCPIAAAEKLAKSHEKQQPQTGDPSKSSSNSDRILRPMCFVKQLEVPPYGSYRPNVAPATPRANLAKELEKFSKVTFDYASFDAQVFGKRMLAPKIQTSETSPKAFQCFDYSQDAEAAHMAATAILNLSTRCWEMPENLSTKPQDLPSKSVDIEVDENGTLDLSMHKHRKRENAFPSSSSCSSSPGVKSPDASQRHSSTSAPSSSMTSPQSSQASRQDEWDRPLDYTKPSRLREEEPEESEPAAHSFASSEADDQEVSEENFEERKYPGEVTLTNFKLKFLSKDIKKELLTCPTPGCDGSGHITGNYASHRSLSGCPLADKSLRNLMAAHSADLKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGVKVAPTKDDKEDPELMKCPVPGCVGLGHISGKYASHRSASGCPLAARRQKEGSLNGSSFSWKSLKNEGPTCPTPGCDGSGHANGSFLTHRSLSGCPRATFAGKKGKLSGDEVLSPKFKTSDVLENDEEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQALIQSLANIRLPHMEPICEQNFDAYVSTLTDMYSNQDPENKDLLESIKQAVRGIQV"},{"id":"SEQ_01262","a":"Q8NCB2","g":"CAMKV","d":"CaM kinase-like vesicle-associated protein","L":501,"m":[{"c":"-x[SR]x[TV]P[AT]T","u":8,"sp":"tandem","x":"disordered_like","cf":"high","why":"Head-to-tail array of 8 octapeptide repeats in the C-terminal disordered region, comprising 7 highly conserved core units (D[GR][SR][AVI]TPAT) followed immediately in register by an 8th divergent unit (EESTVPTT) retaining the acidic N-terminus, pos-3 S, and fixed P6/T8 anchors.","i":[[383,390,"DRSATPAT"],[391,398,"DGSATPAT"],[399,406,"DGSVTPAT"],[407,414,"DGSITPAT"],[415,422,"DGSVTPAT"],[423,430,"DRSATPAT"],[431,438,"DGRATPAT"],[439,446,"EESTVPTT"]]}],"s":"MPFGCVTLGDKKNYNQPSEVTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGILKMVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAYLHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKEPCGTPEYLAPEVVGRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWDDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNFARAKWKKAVRVTTLMKRLRAPEQSSTAAAQSASATDTATPGAAGGATAAAASGATSAPEGDAARAAKSDNVAPADRSATPATDGSATPATDGSVTPATDGSITPATDGSVTPATDRSATPATDGRATPATEESTVPTTQSSAMLATKAAATPEPAMAQPDSTAPEGATGQAPPSSKGEEAAGYAQESQREEAS"},{"id":"SEQ_01282","a":"Q9H6E5","g":"TUT1","d":"Speckle targeted PIP5K1A-regulated poly(A) polymerase","L":874,"m":[{"c":"x[SAD]x[PTA][PL]ASP","u":8,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Five clustered 8-aa motifs within a 70-residue Pro/Ser-rich disordered linker (residues 241-310) sharing an invariant C-terminal ASP tripeptide preceded by constrained [PTA][PL] positions, arranged as two close/tandem pairs separated by a 24-aa linker (with zero ASP occurrences elsewhere in the 874-aa sequence).","i":[[241,248,"LDSALASP"],[254,261,"LACTPASP"],[263,270,"DSQPPASP"],[295,302,"ASETLASP"],[303,310,"QSLPPASP"]]}],"s":"MAAVDSDVESLPRGGFRCCLCHVTTANRPSLDAHLGGRKHRHLVELRAARKAQGLRSVFVSGFPRDVDSAQLSEYFLAFGPVASVVMDKDKGVFAIVEMGDVGAREAVLSQSQHSLGGHRLRVRPREQKEFQSPASKSPKGAAPDSHQLAKALAEAADVGAQMIKLVGLRELSEAERQLRSLVVALMQEVFTEFFPGCVVHPFGSSINSFDVHGCDLDLFLDLGDLEEPQPVPKAPESPSLDSALASPLDPQALACTPASPPDSQPPASPQDSEALDFETPSSSLAPQTPDSALASETLASPQSLPPASPLLEDREEGDLGKASELAETPKEEKAEGAAMLELVGSILRGCVPGVYRVQTVPSARRPVVKFCHRPSGLHGDVSLSNRLALHNSRFLSLCSELDGRVRPLVYTLRCWAQGRGLSGSGPLLSNYALTLLVIYFLQTRDPPVLPTVSQLTQKAGEGEQVEVDGWDCSFPRDASRLEPSINVEPLSSLLAQFFSCVSCWDLRGSLLSLREGQALPVAGGLPSNLWEGLRLGPLNLQDPFDLSHNVAANVTSRVAGRLQNCCRAAANYCRSLQYQRRSSRGRDWGLLPLLQPSSPSSLLSATPIPLPLAPFTQLTAALVQVFREALGCHIEQATKRTRSEGGGTGESSQGGTSKRLKVDGQKNCCEEGKEEQQGCAGDGGEDRVEEMVIEVGEMVQDWAMQSPGQPGDLPLTTGKHGAPGEEGQPSHAALAERGPKGHEAAQEWSQGEAGKGASLPSSASWRCALWHRVWQGRRRARRRLQQQTKEGAGGGAGTRAGWLATEAQVTQELKGLSGGEERPETEPLLSFVASVSPADRMLTVTPLQDPQGLFPDLHHFLQVFLPQAIRHLK"},{"id":"SEQ_01313","a":"Q8TB24","g":"RIN3","d":"Ras and Rab interactor 3","L":985,"m":[{"c":"ψxψψAR(x){3,4}TEMLxxψxxMMxxψ","u":"23-24","sp":"dispersed","x":"structured_like","cf":"high","why":"Strongly conserved 23-24 aa internal duplication in the C-terminal structured helical region (residues 628-651 and 791-813) anchored by eight identical residues (AR, TEML, MM) and five conserved large-aliphatic (ψ) positions across a short 3-4 residue polar turn.","i":[[628,651,"LEMMARQTSSTEMLQEIRTMMTQL"],[792,814,"MYVLARSNLTEMLLNVEYMMELM"]]}],"s":"MIRHAGAPARGDPTGPVPVVGKGEEEEEEDGMRLCLPANPKNCLPHRRGISILEKLIKTCPVWLQLSLGQAEVARILHRVVAGMFLVRRDSSSKQLVLCVHFPSLNESSAEVLEYTIKEEKSILYLEGSALVFEDIFRLIAFYCVSRDLLPFTLRLPQAILEASSFTDLETIANLGLGFWDSSLNPPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKKPSMILGKARHRLSFASFSSMFHAFLSNNRKLYKKVVELAQDKGSYFGSLVQDYKVYSLEMMARQTSSTEMLQEIRTMMTQLKSYLLQSTELKALVDPALHSEEELEAIVESALYKCVLKPLKEAINSCLHQIHSKDGSLQQLKENQLVILATTTTDLGVTTSVPEVPMMEKILQKFTSMHKAYSPEKKISILLKTCKLIYDSMALGNPGKPYGADDFLPVLMYVLARSNLTEMLLNVEYMMELMDPALQLGEGSYYLTTTYGALEHIKSYDKITVTRQLSVEVQDSIHRWERRRTLNKARASRSSVQDFICVSYLEPEQQARTLASRADTQAQALCAQCAEKFAVERPQAHRLFVLVDGRCFQLADDALPHCIKGYLLRSEPKRDFHFVYRPLDGGGGGGGGSPPCLVVREPNFL"},{"id":"SEQ_01318","a":"O15117","g":"FYB1","d":"FYN-binding protein 1","L":783,"m":[{"c":"KKFKφxG[PE]I[QR]Vψ[HY]x[AT]K(x){10,13}-LoφK[QP]GEoψEψI[RQ]xTD[ND](x){1,3}KφL[GC]RoxxG[SK]YGYψxxoφψ[EA]","u":"67-68","sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 67-68 aa structured domain repeats in the C-terminal half sharing fixed KKFK, GE, TD, and YGY anchors plus conserved hydrophobic core positions across two short variable loops.","i":[[502,568,"KKFKLTGPIQVIHLAKACCDVKGGKNELSFKQGEQIEIIRITDNPEGKWLGRTARGSYGYIKTTAVE"],[697,764,"KKFKYDGEIRVLYSTKVTTSITSKKWGTRDLQVKPGESLEVIQTTDDTKVLCRNEEGKYGYVLRSYLA"]]},{"c":"[DG][DGQ]-[VI]YD[DG][VI][ADE]","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four non-overlapping 9-aa repeats dispersed across acidic disordered C-terminal linker and tail segments, anchored by an invariant YD core flanked by conserved [VI] aliphatic and acidic/glycine positions.","i":[[591,599,"DQEVYDDVA"],[621,629,"DDDIYDGIE"],[647,655,"GDEVYDDVD"],[767,775,"DGEIYDDIA"]]}],"s":"MAKYNTGGNPTEDVSVNSRPFRVTGPNSSSGIQARKNLFNNQGNASPPAGPSNVPKFGSPKPPVAVKPSSEEKPDKEPKPPFLKPTGAGQRFGTPASLTTRDPEAKVGFLKPVGPKPINLPKEDSKPTFPWPPGNKPSLHSVNQDHDLKPLGPKSGPTPPTSENEQKQAFPKLTGVKGKFMSASQDLEPKPLFPKPAFGQKPPLSTENSHEDESPMKNVSSSKGSPAPLGVRSKSGPLKPAREDSENKDHAGEISSLPFPGVVLKPAASRGGPGLSKNGEEKKEDRKIDAAKNTFQSKINQEELASGTPPARFPKAPSKLTVGGPWGQSQEKEKGDKNSATPKQKPLPPLFTLGPPPPKPNRPPNVDLTKFHKTSSGNSTSKGQTSYSTTSLPPPPPSHPASQPPLPASHPSQPPVPSLPPRNIKPPFDLKSPVNEDNQDGVTHSDGAGNLDEEQDSEGETYEDIEASKEREKKREKEEKKRLELEKKEQKEKEKKEQEIKKKFKLTGPIQVIHLAKACCDVKGGKNELSFKQGEQIEIIRITDNPEGKWLGRTARGSYGYIKTTAVEIDYDSLKLKKDSLGAPSRPIEDDQEVYDDVAEQDDISSHSQSGSGGIFPPPPDDDIYDGIEEEDADDGFPAPPKQLDMGDEVYDDVDTSDFPVSSAEMSQGTNVGKAKTEEKDLKKLKKQEKEEKDFRKKFKYDGEIRVLYSTKVTTSITSKKWGTRDLQVKPGESLEVIQTTDDTKVLCRNEEGKYGYVLRSYLADNDGEIYDDIADGCIYDND"},{"id":"SEQ_01320","a":"Q58F21","g":"BRDT","d":"Bromodomain testis-specific protein","L":947,"m":[{"c":"ψT[NE]QL[QR][YH]xoxψψxxxLφK(x){4,6}WPF[QY][RN]PVDφxxL[QG]L[PH][DN]YY[TD]ψψKNPMDL[NG]TIK[KE]+ψ-N[KQ]xYxxAxxxφxDφxxMFxNCYxYN[KP]P[GD][DH]-ψVxMA[QR]φL[EQ]xψFxo[KH]φS[QK]ψP","u":"107-109","sp":"dispersed","x":"structured_like","cf":"high","why":"Two highly conserved 107-109 aa structured repeats in the N-terminal region featuring identical WPF, PVD, YY, KNPMDL, TIK, MFxNCYxYN, and MA motifs separated by a ~134 aa linker.","i":[[28,134,"LTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMP"],[269,377,"VTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIP"]]}],"s":"MSLPSRQTAIIVNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQQEIPSVFPKTSISPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPATSAVKASSEFSPTFTEKSVALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERVKRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRLKEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSREPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSSDSSDSESEMFPKFTEVKPNDSPSKENVKKMKNECIPPEGRTGVTQIGYCVQDTTSANTTLVHQTTPSHVMPPNHHQLAFNYQELEHLQTVKNISPLQILPPSGDSEQLSNGITVMHPSGDSDTTMLESECQAPVQKDIKIKNADSWKSLGKPVKPSGVMKSSDELFNQFRKAAIEKEVKARTQELIRKHLEQNTKELKASQENQRDLGNGLTVESFSNKIQNKCSGEEQKEHQQSSEAQDKSKLWLLKDRDLARQKEQERRRREAMVGTIDMTLQSDIMTMFENNFD"},{"id":"SEQ_01340","a":"O60506","g":"SYNCRIP","d":"Heterogeneous nuclear ribonucleoprotein Q","L":623,"m":[{"c":"ψFV[GR]xψ[PA]xxx[FT][EK]-xψxxxF[ES][KQ]φ[GT]xx(x){7,17}[GD]Ω[AC]FψxΩx[TDE][KHR]xxAxxAxxxφ[NM]x(x){6,7}[HN]ψ[GE][VTI][CV]xxx","u":"68-79","sp":"dispersed","x":"structured_like","cf":"high","why":"Three structured ~68-79 aa globular repeats separated by short variable linkers (4 and 16 aa), strongly anchored by an N-terminal ψFV motif, conserved F/φ hydrophobic core positions, and a central [GD]Ω[AC]FψxΩ aromatic-hydrophobic signature followed by conserved AxxAxxxφ helical and C-terminal ψ[GE][VTI][CV] positions.","i":[[164,240,"IFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISV"],[245,323,"LFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWA"],[340,407,"LFVRNLANTVTEEILEKAFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAK"]]},{"c":"[DP]YYGY-[DY]","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three non-overlapping 7-residue copies in the C-terminal disordered tail sharing an invariant YYGY aromatic-glycine core flanked by N-terminal D/P and C-terminal acidic (-)/[DY] positions, separated by 2- and 8-aa linkers.","i":[[459,465,"DYYGYED"],[468,474,"DYYGYDY"],[484,490,"PYYGYED"]]}],"s":"MATEHVNGNGTEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADSSKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILEKAFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQMYDDYYYYGPPHMPPPTRGRGRGGRGGYGYPPDYYGYEDYYDYYGYDYHNYRGGYEDPYYGYEDFQVGARGRGGRGARGAAPSRGRGAAPPRGRAGYSQRGGPGSARGVRGARGGAQQQRGRGVRGARGGRGGNVGGKRKADGYNQPDSKRRQTNNQNWGSQPIAQQPLQGGDHSGNYGYKSENQEFYQDTFGQQWK"},{"id":"SEQ_01352","a":"Q9P244","g":"LRFN1","d":"Leucine-rich repeat and fibronectin type III domain-containing protein 1","L":771,"m":[{"c":"ψ(x){2,3}Lx[LM]xxNx[IL]xxψxxxxφxxφxx","u":"24-25","sp":"tandem","x":"structured_like","cf":"high","why":"Seven contiguous head-to-tail 24-25 aa structured repeats (residues 67-235) anchored by strictly invariant L and N residues alongside regularly spaced aliphatic ([LM], [IL], ψ) and hydrophobic (φ) core positions, with a single-residue insertion in the fifth repeat.","i":[[67,90,"VVELRLTDNFIAAVRRRDFANMTS"],[91,114,"LVHLTLSRNTIGQVAAGAFADLRA"],[115,138,"LRALHLDSNRLAEVRGDQLRGLGN"],[139,162,"LRHLILGNNQIRRVESAAFDAFLS"],[163,187,"TVEDLDLSYNNLEALPWEAVGQMVN"],[188,211,"LNTLTLDHNLIDHIAEGTFVQLHK"],[212,235,"LVRLDMTSNRLHKLPPDGLFLRSQ"]]}],"s":"MAPGPFSSALLSPPPAALPFLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPKPPTPLTVSFGGNPLHCNCELLWLRRLTREDDLETCATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEPGSSDIATPGRPGANDSAAERRLVAAELTSNSVLIRWPAQRPVPGIRMYQVQYNSSVDDSLVYRMIPSTSQTFLVNDLAAGRAYDLCVLAVYDDGATALPATRVVGCVQFTTAGDPAPCRPLRAHFLGGTMIIAIGGVIVASVLVFIVLLMIRYKVYGDGDSRRVKGSRSLPRVSHVCSQTNGAGTGAAQAPALPAQDHYEALREVESQAAPAVAVEAKAMEAETASAEPEVVLGRSLGGSATSLCLLPSEETSGEESRAAVGPRRSRSGALEPPTSAPPTLALVPGGAAARPRPQQRYSFDGDYGALFQSHSYPRRARRTKRHRSTPHLDGAGGGAAGEDGDLGLGSARACLAFTSTEWMLESTV"},{"id":"SEQ_01355","a":"Q9UBF9","g":"MYOT","d":"Myotilin","L":498,"m":[{"c":"PxFIxxPxoxxψxEGxxx+ψ-xxψS[GA]ψP[AP]PxψxWxxN[GN]xxVQ(x){12,13}Gxx[ST]LψφxxVxxxDAGφYxxxAxNxAGxxTxoxxLDVxA","u":"93-94","sp":"periodic","x":"structured_like","cf":"high","why":"Two 93-94 aa structured domain repeats separated by a 6-aa linker, strongly conserved across N-terminal PxFIxxP...EG, central S[GA]ψP[AP]PxψxWxxN[GN]xxVQ, and C-terminal DAGφY...AGxxTxoxxLDVxA motifs.","i":[[250,342,"PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLA"],[349,442,"PMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTA"]]}],"s":"MFNYERPKHFIQSQNPCGSRLQPPGPETSSFSSQTKQSSIIIQPRQCTEQRFSASSTLSSHITMSSSAFPASPQQHAGSNPGQRVTTTYNQSPASFLSSILPSQPDYNSSKIPSAMDSNYQQSSAGQPINAKPSQTANAKPIPRTPDHEIQGSKEALIQDLERKLKCKDTLLHNGNQRLTYEEKMARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLNVKQAFNPEGEFQRLAAQSGLYESEEL"},{"id":"SEQ_01370","a":"Q8TBC3","g":"SHKBP1","d":"SH3KBP1-binding protein 1","L":707,"m":[{"c":"ψxxxxxx[GSN]xψxxWxφ","u":15,"sp":"dispersed","x":"structured_like","cf":"medium","why":"Four dispersed 15-aa structured beta-blade core repeats anchored by a conserved Trp (pos 13), flanking aliphatic/hydrophobic positions (pos 1, 10, 15), and a small/polar turn residue at pos 8.","i":[[258,272,"MVAAATGSEILLWAL"],[300,314,"LIATSHTGRIGVWNA"],[444,458,"ISVCADNNHVRTWSV"],[564,578,"LLTGQANGSLAMWDL"]]}],"s":"MAAAATAAEGVPSRGPPGEVIHLNVGGKRFSTSRQTLTWIPDSFFSSLLSGRISTLKDETGAIFIDRDPTVFAPILNFLRTKELDPRGVHGSSLLHEAQFYGLTPLVRRLQLREELDRSSCGNVLFNGYLPPPVFPVKRRNRHSLVGPQQLGGRPAPVRRSNTMPPNLGNAGLLGRMLDEKTPPSPSGQPEEPGMVRLVCGHHNWIAVAYTQFLVCYRLKEASGWQLVFSSPRLDWPIERLALTARVHGGALGEHDKMVAAATGSEILLWALQAEGGGSEIGVFHLGVPVEALFFVGNQLIATSHTGRIGVWNAVTKHWQVQEVQPITSYDAAGSFLLLGCNNGSIYYVDVQKFPLRMKDNDLLVSELYRDPAEDGVTALSVYLTPKTSDSGNWIEIAYGTSSGGVRVIVQHPETVGSGPQLFQTFTVHRSPVTKIMLSEKHLISVCADNNHVRTWSVTRFRGMISTQPGSTPLASFKILALESADGHGGCSAGNDIGPYGERDDQQVFIQKVVPSASQLFVRLSSTGQRVCSVRSVDGSPTTAFTVLECEGSRRLGSRPRRYLLTGQANGSLAMWDLTTAMDGLGQAPAGGLTEQELMEQLEHCELAPPAPSAPSWGCLPSPSPRISLTSLHSASSNTSLSGHRGSPSPPQAEARRRGGGSFVERCQELVRSGPDLRRPPTPAPWPSSGLGTPLTPPKMKLNETSF"},{"id":"SEQ_01390","a":"Q6S5H5","g":"POTEG","d":"POTE ankyrin domain family member G","L":508,"m":[{"c":"LRSKMGKWC[RC]HCFP[WC]CRGS[GS]KS[NK]VG[TP][SW]GD[HY]DDSA[MF]","u":35,"sp":"tandem","x":"mixed","cf":"high","why":"Three highly conserved 35-aa N-terminal repeats separated by 2-aa KT linkers, anchored by an invariant Cys/His/Trp-rich core (LRSKMGKWCxHCFPxCRGS) and a conserved acidic C-terminal segment (GDxDDSA[MF]).","i":[[20,54,"LRSKMGKWCRHCFPWCRGSGKSNVGTSGDHDDSAM"],[57,91,"LRSKMGKWCRHCFPWCRGSSKSNVGTSGDHDDSAM"],[94,128,"LRSKMGKWCCHCFPCCRGSGKSKVGPWGDYDDSAF"]]},{"c":"[DN]xx[GK]xT[AP][LR]xx[AG][VIS]xxxxxxx[VAC]xφLxxxxxxxxxx","u":33,"sp":"tandem","x":"structured_like","cf":"high","why":"Six contiguous head-to-tail 33-aa structural repeats featuring conserved N-terminal [DN]xx[GK]xT[AP][LR]xx[AG] and central hydrophobic φL core positions.","i":[[170,202,"DKQKRTALHLASANGNSEVVKLLLDRRCQLNIL"],[203,235,"DNKKRTALTKAVQCREDECALMLLEHGTDPNIP"],[236,268,"DEYGNTALHYAIYNEDKLMAKALLLYGADIESK"],[269,301,"NKHGLTPLLLGVHEQKQQVVKFLIKKKANLNAL"],[302,334,"DRYGRTALILAVCCGSASIVSLLLEQNIDVSSQ"],[335,367,"DLSGQTAREYAVSSHHNVICQLLSDYKEKQMLK"]]}],"s":"MVAEAGSMPAASSVKKPFGLRSKMGKWCRHCFPWCRGSGKSNVGTSGDHDDSAMKTLRSKMGKWCRHCFPWCRGSSKSNVGTSGDHDDSAMKTLRSKMGKWCCHCFPCCRGSGKSKVGPWGDYDDSAFMEPRYHVRREDLDKLHRAAWWGKVPRKDLIVMLKDTDMNKKDKQKRTALHLASANGNSEVVKLLLDRRCQLNILDNKKRTALTKAVQCREDECALMLLEHGTDPNIPDEYGNTALHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHNVICQLLSDYKEKQMLKVSSENSNPEQDLKLTSEEESQRLKGSENSQPEEMSQEPEINKGGDRKVEEEMKKHGSTHMGFPENLPNGATADNGDDGLIPPRKSRTPESQQFPDTENEQYHSDEQNDTQKQLSEEQNTGILQDEILIHEEKQIEVAENEF"},{"id":"SEQ_01402","a":"Q96NY7","g":"CLIC6","d":"Chloride intracellular channel protein 6","L":704,"m":[{"c":"GD[SNG]ψ[DEQ]A[EG][GDV][PR][AVL]","u":10,"sp":"tandem","x":"disordered_like","cf":"high","why":"Thirteen contiguous head-to-tail 10-aa repeats in the disordered N-terminal region anchored by invariant G1, D2, and A6 positions alongside strictly conserved aliphatic ψ4 and [PR]9-[AVL]10 positions.","i":[[157,166,"GDSVDAEGPL"],[167,176,"GDNIEAEGPA"],[177,186,"GDSVEAEGRV"],[187,196,"GDSVDAEGPA"],[197,206,"GDSVDAEGPL"],[207,216,"GDNIQAEGPA"],[217,226,"GDSVDAEGRV"],[227,236,"GDSVDAEGPA"],[237,246,"GDSVDAEGRV"],[247,256,"GDSVEAGDPA"],[257,266,"GDGVEAGVPA"],[267,276,"GDSVEAEGPA"],[277,286,"GDSMDAEGPA"]]}],"s":"MAEAAEPEGVAPGPQGPPEVPAPLAERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEAGGGGPDRGPEAEARGTRGAHGETEAEEGAPEGAEVPQGGEETSGAQQVEGASPGRGAQGEPRGEAQREPEDSAAPERQEEAEQRPEVPEGSASGEAGDSVDAEGPLGDNIEAEGPAGDSVEAEGRVGDSVDAEGPAGDSVDAEGPLGDNIQAEGPAGDSVDAEGRVGDSVDAEGPAGDSVDAEGRVGDSVEAGDPAGDGVEAGVPAGDSVEAEGPAGDSMDAEGPAGRARRVSGEPQQSGDGSLSPQAEAIEVAAGESAGRSPGELAWDAAEEAEVPGVKGSEEAAPGDARADAGEDRVGDGPQQEPGEDEERRERSPEGPREEEAAGGEEESPDSSPHGEASRGAAEPEAQLSNHLAEEGPAEGSGEAARVNGRREDGEASEPRALGQEHDITLFVKVKLTALGCSRIAIKKYLRAGYDGESIGNCPFSQRLFMILWLKGVIFNVTTVDLKRKPADLQNLAPGTNPPFMTFDGEVKTDVNKIEEFLEEKLAPPRYPKLGTQHPESNSAGNDVFAKFSAFIKNTKKDANEIHEKNLLKALRKLDNYLNSPLPDEIDAYSTEDVTVSGRKFLDGDELTLADCNLLPKLHIIKIVAKKYRDFEFPSEMTGIWRYLNNAYARDEFTNTCPADQEIEHAYSDVAKRMK"},{"id":"SEQ_01422","a":"Q07890","g":"SOS2","d":"Son of sevenless homolog 2","L":1332,"m":[{"c":"[PA]P[PA]xP[PL]R","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five dispersed copies in the C-terminal proline-rich disordered tail share invariant P2, P5, and C-terminal R7 anchors with constrained [PA] at positions 1/3, [PL] at position 6, and a large aliphatic residue (L/I/V) at position 4 in four of five repeats.","i":[[1146,1152,"PPPLPPR"],[1172,1178,"PPAIPPR"],[1203,1209,"PPPPPPR"],[1216,1222,"PPPVPLR"],[1289,1295,"APPVPPR"]]}],"s":"MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILSPEFHEHFNKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLYRLPLLENAETPQ"},{"id":"SEQ_01431","a":"Q9BR39","g":"JPH2","d":"Junctophilin-2","L":696,"m":[{"c":"[YF]xGx[WF]xx[GDN]xxx[GAR]x[GV]x","u":15,"sp":"dispersed","x":"structured_like","cf":"high","why":"Eight 15-residue copies (six closely spaced in the N-terminal region and two in the central region separated by a 147-aa linker) anchored by invariant [YF]-x-G-x-[WF] N-terminal aromatics/glycine, a conserved [GDN] turn position, and a C-terminal GxG-like motif.","i":[[14,28,"YCGGWEGGKAHGHGL"],[38,52,"YSGSWNFGFEVAGVY"],[60,74,"FEGYWSQGKRHGLGI"],[82,96,"YKGEWTHGFKGRYGI"],[106,120,"YEGTWNNGLQDGYGT"],[129,143,"YQGQFTNGMRHGYGV"],[291,305,"YMGEWKNDKRSGFGV"],[314,328,"YEGEWLDNLRHGYGC"]]}],"s":"MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSSSSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYGMAVVVRSPLRTSLSSLRSEHSNGTVAPDSPASPASDGPALPSPAIPRGGFALSLLANAEAAARAPKGGGLFQRGALLGKLRRAESRTSVGSQRSRVSFLKSDLSSGASDAASTASLGEAAEGADEAAPFEADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGCTTLPDGHREEGKYRHNVLVKDTKRRMLQLKSNKVRQKVEHSVEGAQRAAAIARQKAEIAASRTSHAKAKAEAAEQAALAANQESNIARTLARELAPDFYQPGPEYQKRRLLQEILENSESLLEPPDRGAGAAGLPQPPRESPQLHERETPRPEGGSPSPAGTPPQPKRPRPGVSKDGLLSPGAWNGEPSGEGSRSVTPSEGAGRRSPARPATERMAIEALQAPPAPSREPEVALYQGYHSYAVRTTPPEPPPFEDQPEPEVSGSESAPSSPATAPLQAPTLRGPEPARETPAKLEPKPIIPKAEPRAKARKTEARGLTKAGAKKKARKEAALAAEAEVEVEEVPNTILICMVILLNIGLAILFVHLLT"},{"id":"SEQ_01441","a":"Q6VAB6","g":"KSR2","d":"Kinase suppressor of Ras 2","L":950,"m":[{"c":"[TK]PP[RG]TP[PN]","u":7,"sp":"periodic","x":"disordered_like","cf":"medium","why":"Three clustered 7-residue copies separated by regular 5-7 aa linkers within the central disordered region, sharing a conserved PP-[RG]-TP core with flanking [TK] and [PN] positions.","i":[[260,266,"TPPRTPN"],[272,278,"TPPGTPP"],[286,292,"KPPGTPP"]]}],"s":"MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLLEMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL"},{"id":"SEQ_01459","a":"P50502","g":"ST13","d":"Hsc70-interacting protein","L":369,"m":[{"c":"xAxx[KY][KA]x[AR][AG]xxxxx[DL][GQ]xxxxA[IA]x[LD]xxxA[IC][KE][LI][ND][PY][RD]","u":34,"sp":"tandem","x":"structured_like","cf":"high","why":"Three head-to-tail 34-residue helical repeats in the central structured domain anchored by invariant A at positions 2, 21, and 28 alongside conserved small/hydrophobic core positions ([AG]9, [IA]22, [LI]31) and C-terminal turn residues ([ND][PY][RD]).","i":[[113,146,"QANDKKVAAIEALNDGELQKAIDLFTDAIKLNPR"],[147,180,"LAILYAKRASVFVKLQKPNAAIRDCDRAIEINPD"],[181,214,"SAQPYKWRGKAHRLLGHWEEAAHDLALACKLDYD"]]},{"c":"[SQ][DN]Px[VN][LM]xxφ","u":9,"sp":"dispersed","x":"structured_like","cf":"high","why":"Four closely spaced 9-residue repeats in the C-terminal helical region featuring an invariant P3 preceded by [SQ][DN] and followed by conserved aliphatic [LM]6 and C-terminal hydrophobic φ9 anchors.","i":[[318,326,"SDPEVLAAM"],[327,335,"QDPEVMVAF"],[340,348,"QNPANMSKY"],[350,358,"SNPKVMNLI"]]},{"c":"[GA]GMPG[MNL]","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Four non-overlapping 6-residue repeats in the G/M/P-enriched linker (residues 287-313) anchored by an invariant GMPG core flanked by [GA]1 and [MNL]6.","i":[[287,292,"GGMPGN"],[295,300,"GGMPGM"],[302,307,"GGMPGM"],[308,313,"AGMPGL"]]}],"s":"MDPRKVNELRAFVKMCKQDPSVLHTEEMRFLREWVESMGGKVPPATQKAKSEENTKEEKPDSKKVEEDLKADEPSSEESDLEIDKEGVIEPDTDAPQEMGDENAEITEEMMDQANDKKVAAIEALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLALACKLDYDEDASAMLKEVQPRAQKIAEHRRKYERKREEREIKERIERVKKAREEHERAQREEEARRQSGAQYGSFPGGFPGGMPGNFPGGMPGMGGGMPGMAGMPGLNEILSDPEVLAAMQDPEVMVAFQDVAQNPANMSKYQSNPKVMNLISKLSAKFGGQA"},{"id":"SEQ_01468","a":"Q8NAV1","g":"PRPF38A","d":"Pre-mRNA-splicing factor 38A","L":312,"m":[{"c":"[RH]R[HE]R[SH][RH]SKSP","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 10-residue motifs in the C-terminal basic/polar disordered tail anchored by an invariant C-terminal SKSP tetrapeptide, fixed R2 and R4 positions, and constrained [RH]/[HE]/[SH] flanking positions.","i":[[254,263,"RRERHRSKSP"],[273,282,"RRHRSRSKSP"],[288,297,"HRHRSHSKSP"]]}],"s":"MANRTVKDAHSIHGTNPQYLVEKIIRTRIYESKYWKEECFGLTAELVVDKAMELRFVGGVYGGNIKPTPFLCLTLKMLQIQPEKDIIVEFIKNEDFKYVRMLGALYMRLTGTAIDCYKYLEPLYNDYRKIKSQNRNGEFELMHVDEFIDELLHSERVCDIILPRLQKRYVLEEAEQLEPRVSALEEDMDDVESSEEEEEEDEKLERVPSPDHRRRSYRDLDKPRRSPTLRYRRSRSRSPRRRSRSPKRRSPSPRRERHRSKSPRRHRSRSRDRRHRSRSKSPGHHRSHRHRSHSKSPERSKKSHKKSRRGNE"},{"id":"SEQ_01473","a":"Q969R5","g":"L3MBTL2","d":"Lethal(3)malignant brain tumor-like protein 2","L":705,"m":[{"c":"GM[KR][LV]E[VA]ψ[ND]xxxxxxxxψ[AY]xψxxVψ(x){2,5}[RL]xxxxxxG(x){4,7}D[FWQ][WF][CV](x){8,9}P[IVA][GT][WF][CS]","u":"56-61","sp":"periodic","x":"structured_like","cf":"high","why":"Four highly conserved 56-61 aa globular beta-core repeats separated by regular ~48-52 aa N-terminal arm linkers (forming four ~105-aa structural repeats), anchored by N-terminal GM[KR][LV]E[VA]ψ[ND], internal Vψ and G positions, an aromatic D[FWQ][WF][CV] motif, and C-terminal P[IVA][GT][WF][CS].","i":[[213,273,"GMKVEVLNSDAVLPSRVYWIASVIQTAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWC"],[326,381,"GMRLEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWS"],[431,490,"GMKLEAIDPLNLGNICVATVCKVLLDGYLMICVDGGPSTDGLDWFCYHASSHAIFPATFC"],[539,594,"GMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQWVDCESPDIYPVGWC"]]}],"s":"MEKPRSIEETPSSEPMEEEEDDDLELFGGYDSFRSYNSSVGSESSSYLEESSEAENEDREAGELPTSPLHLLSPGTPRSLDGSGSEPAVCEMCGIVGTREAFFSKTKRFCSVSCSRSYSSNSKKASILARLQGKPPTKKAKVLHKAAWSAKIGAFLHSQGTGQLADGTPTGQDALVLGFDWGKFLKDHSYKAAPVSCFKHVPLYDQWEDVMKGMKVEVLNSDAVLPSRVYWIASVIQTAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFTDWKGYLMKRLVGSRTLPVDFHIKMVESMKYPFRQGMRLEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGIKMSERRSDMAHHPTFRKIYCDAVPYLFKKVRAVYTEGGWFEEGMKLEAIDPLNLGNICVATVCKVLLDGYLMICVDGGPSTDGLDWFCYHASSHAIFPATFCQKNDIELTPPKGYEAQTFNWENYLEKTKSKAAPSRLFNMDCPNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQLQPPVAAEPATPLKAKEATKKKKKQFGKKRKRIPPTKTRPLRQGSKKPLLEDDPQGARKISSEPVPGEIIAVRVKEEHLDVASPDKASSPELPVSVENIKQETDD"},{"id":"SEQ_01475","a":"Q8IZ40","g":"RCOR2","d":"REST corepressor 2","L":523,"m":[{"c":"TxFxxxWT[VT]--[KQ]ψLφxQAφxx[HY]GK[CD]F[QG]xIx[QE]ψψ[PG][DN]Kxψ[PT]oψx[KT]ΩΩφSΩ++","u":50,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 50-aa structured repeat domains separated by a 147-aa linker, anchored by N-terminal TxFxxxWT, central QAφxx[HY]GK[CD]F, and a C-terminal aromatic-basic ΩΩφSΩ++ cluster.","i":[[129,178,"TPFPDEWTVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWKK"],[326,375,"TKFNSRWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYRR"]]},{"c":"QPPP[LPT][LQ]x[PGR][PRT]x[LP]x[AP][PR]","u":14,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four non-overlapping 14-aa repeats in the C-terminal proline-rich disordered tail separated by short 4-8 aa linkers, anchored by an invariant QPPP N-terminus and conserved downstream [LQ], [LP], and [AP][PR] positions.","i":[[448,461,"QPPPLLRPPLPTAP"],[466,479,"QPPPLQQGRFLQPR"],[484,497,"QPPPPLIRPALAAP"],[506,519,"QPPPTLIGTPLEPP"]]}],"s":"MPSVMEKPSAGSGILSRSRAKTVPNGGQPHSEDDSSEEEHSHDSMIRVGTNYQAVIPECKPESPARYSNKELKGMLVWSPNHCVSDAKLDKYIAMAKEKHGYNIEQALGMLLWHKHDVEKSLADLANFTPFPDEWTVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWKKTRSRTSVMDRQARRLGGRKDKEDSDELEEGRGGVSEGEPDPADPKREPLPSRPLNARPGPGKKEVQVSQYRHHPLRTRRRPPKGMYLSPEGLTAVSGSPDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQALEGGIDPLRPPEANTKFNSRWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYRRRFNLEEVLQEWEAEQDGAPGAPVPMEEARRGAPLPAPALEEDDEVQITSVSTSVPRSVPPAPPPPPPPTSLSQPPPLLRPPLPTAPTLLRQPPPLQQGRFLQPRLAPNQPPPPLIRPALAAPRHSARPGPQPPPTLIGTPLEPPAPSL"},{"id":"SEQ_01486","a":"Q96PN7","g":"TRERF1","d":"Transcriptional-regulating factor 1","L":1200,"m":[{"c":"φxC(x){2,4}C[GL][KA][EV]Fxxxx[AS][LR]N[GA]H[MA]+xH","u":"23-25","sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed 23-25 aa Cys2-His2 zinc-finger-like repeats anchored by an N-terminal hydrophobic residue before the C(x){2,4}C knuckle, an invariant central F and N, and a conserved H[MA]+xH C-terminal motif.","i":[[512,534,"LTCSICLKEFKNLPALNGHMRSH"],[1013,1037,"FICEMPNCGAVFSSRQALNGHARIH"],[1086,1108,"FPCKECGKVFFKIKSRNAHMKTH"]]}],"s":"MGDQQLYKTNHVAHGSENLFYQQPPLGVHSGLNHNYGNAVTGGGMDAPQASPISPHFPQDTRDGLGLPVGSKNLGQMDTSRQGGWGSHAGPGNHVQLRGNLANSNMMWGAPAQAEPTDGYQYTYSQASEIRTQKLTSGVLHKLDSFTQVFANQNLRIQVNNMAQVLHTQSAVMDGAPDSALRQLLSQKPMEPPAPAIPSRYQQVPQQPHPGFTGGLSKPALQVGQHPTQGHLYYDYQQPLAQVPVQGGQPLQAPQMLSQHMQQMQQHQYYPPQQQQQAGQQRISMQEIQTQPQQIRPSQPQPPPQQQQPQQLQLQQRQGSMQIPQYYQPQPMMQHLQEQQQQQMHLQPPSYHRDPHQYTPEQAHTVQLIPLGSMSQYYYQEPQQPYSHPLYQQSHLSQHQQREDSQLKTYSSDRQAQAMLSSHGDLGPPDTGMGDPASSDLTRVSSTLPHRPLLSPSGIHLNNMGPQHQQLSPSAMWPQMHLPDGRAQPGSPESSGQPKGAFGEQFDAKNKLTCSICLKEFKNLPALNGHMRSHGGMRASPNLKQEEGEKVLPPQPQPPLPPPPPPPPPPQLPPEAESLTPMVMPVSVPVKLLPPKPSSQGFTNSTVAAPSARDKPASSMSDDEMPVLEIPRKHQPSVPKAEEPLKTVQEKKKFRHRPEPLFIPPPPSYNPNPAASYSGATLYQSQLRSPRVLGDHLLLDPTHELPPYTPPPMLSPVRQGSGLFSNVLISGHGPGAHPQLPLTPLTPTPRVLLCRSNSIDGSNVTVTPGPGEQTVDVEPRINIGLRFQAEIPELQDISALAQDTHKATLVWKPWPELENHDLQQRVENLLNLCCSSALPGGGTNSEFALHSLFEAKGDVMVALEMLLLRKPVRLKCHPLANYHYAGSDKWTSLERKLFNKALATYSKDFIFVQKMVKSKTVAQCVEYYYTWKKIMRLGRKHRTRLAEIIDDCVTSEEEEELEEEEEEDPEEDRKSTKEEESEVPKSPEPPPVPVLAPTEGPPLQALGQPSGSFICEMPNCGAVFSSRQALNGHARIHGGTNQVTKARGAIPSGKQKPGGTQSGYCSVKSSPSHSTTSGETDPTTIFPCKECGKVFFKIKSRNAHMKTHRQQEEQQRQKAQKAAFAAEMAATIERTTGPVGAPGLLPLDQLSLIKPIKDVDILDDDVVQQLGGVMEEAEVVDTDLLLDDQDSVLLQGDAEL"},{"id":"SEQ_01503","a":"Q9H321","g":"VCX3B","d":"Variable charge X-linked protein 3B","L":246,"m":[{"c":"PLSQES[EQ][VML]EE","u":10,"sp":"tandem","x":"disordered_like","cf":"high","why":"14 contiguous head-to-tail copies of a highly conserved 10-residue repeat in the C-terminal disordered region (residues 103-242), anchored by invariant PLSQES and C-terminal EE flanking [EQ] and a large aliphatic position ([VML]).","i":[[103,112,"PLSQESELEE"],[113,122,"PLSQESEVEE"],[123,132,"PLSQESQVEE"],[133,142,"PLSQESEVEE"],[143,152,"PLSQESQVEE"],[153,162,"PLSQESEVEE"],[163,172,"PLSQESEVEE"],[173,182,"PLSQESQVEE"],[183,192,"PLSQESEVEE"],[193,202,"PLSQESQVEE"],[203,212,"PLSQESEMEE"],[213,222,"PLSQESQVEE"],[223,232,"PLSQESEMEE"],[233,242,"PLSQESEMEE"]]}],"s":"MSPKPRASGPPAKAKEAGKRKSSSQPSPSDPKKKTTKVAKKGKAVRRGRRGKKGAATKMAAVTAPEAESGPAAPGPSDQPSQELPQHELPPEEPVSEGTQHDPLSQESELEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEMEEPLSQESQVEEPLSQESEMEEPLSQESEMEELPSV"},{"id":"SEQ_01519","a":"Q99941","g":"ATF6B","d":"Cyclic AMP-dependent transcription factor ATF-6 beta","L":703,"m":[{"c":"DψQxKxEPxSPCSS(x){0,2}ψoSE[SA]SxLSx-xSSxAφxxxEVLxVKTESL[AS]P[PS]xCLLxDxPxxSφxxVQIoxxPoxDxSS","u":"74-76","sp":"tandem","x":"mixed","cf":"high","why":"Head-to-tail 74-76 aa internal tandem duplication sharing ~51% sequence identity across the full unit, anchored by conserved N-terminal DψQxKxEPxSPCSS, central SE[SA]SxLSx-xSSxAφxxxE, and C-terminal VLxVKTESL[AS]P[PS]xCLL...VQIoxxPoxDxSS blocks with a single 2-aa indel.","i":[[84,159,"DLQVKSEPSSPCSSSSLSSESSRLSTEPSSEALGVGEVLHVKTESLAPPLCLLGDDPTSSFETVQINVIPTSDDSS"],[160,233,"DVQTKIEPVSPCSSVNSEASLLSADSSSQAFIGEEVLEVKTESLSPSGCLLWDVPAPSLGAVQISMGPSLDGSS"]]}],"s":"MAELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQVKSEPSSPCSSSSLSSESSRLSTEPSSEALGVGEVLHVKTESLAPPLCLLGDDPTSSFETVQINVIPTSDDSSDVQTKIEPVSPCSSVNSEASLLSADSSSQAFIGEEVLEVKTESLSPSGCLLWDVPAPSLGAVQISMGPSLDGSSGKALPTRKPPLQPKPVVLTTVPMPSRAVPPSTTVLLQSLVQPPPVSPVVLIQGAIRVQPEGPAPSLPRPERKSIVPAPMPGNSCPPEVDAKLLKRQQRMIKNRESACQSRRKKKEYLQGLEARLQAVLADNQQLRRENAALRRRLEALLAENSELKLGSGNRKVVCIMVFLLFIAFNFGPVSISEPPSAPISPRMNKGEPQPRRHLLGFSEQEPVQGVEPLQGSSQGPKEPQPSPTDQPSFSNLTAFPGGAKELLLRDLDQLFLSSDCRHFNRTESLRLADELSGWVQRHQRGRRKIPQRAQERQKSQPRKKSPPVKAVPIQPPGPPERDSVGQLQLYRHPDRSQPAFLDAIDRREDTFYVVSFRRDHLLLPAISHNKTSRPKMSLVMPAMAPNETLSGRGAPGDYEEMMQIECEVMDTRVIHIKTSTVPPSLRKQPSPTPGNATGGPLPVSAASQAHQASHQPLYLNHP"},{"id":"SEQ_01524","a":"P0C7U0","g":"ELFN1","d":"Protein ELFN1","L":828,"m":[{"c":"[NTK][IL]xx[LI]xLxxNx[IL]xxψxx[GAS]x[FL]xxxx","u":24,"sp":"tandem","x":"structured_like","cf":"high","why":"Five contiguous, un-gapped 24-aa tandem structural repeats defined by invariant L7 and N10 anchors, conserved aliphatic positions ([IL]2, [LI]5, [IL]12, ψ15), and a C-terminal [GAS]18x[FL]20 spine.","i":[[61,84,"TIVDLRLNENRIRSVQYASLSRFG"],[85,108,"NLTYLNLTKNEIGYIEDGAFSGQF"],[109,132,"NLQVLQLGYNRLRNLTEGMLRGLG"],[133,156,"KLEYLYLQANLIEVVMASSFWECP"],[157,180,"NIVNIDLSMNRIQQLNSGTFAGLA"]]}],"s":"MAGRGWGALWVCVAAATLLHAGGLARADCWLIEGDKGFVWLAICSQNQPPYEAIPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKLSVCELYSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSGYYLLGQGRRGHRSILSKLQSVCTEDSYAAEVVGPPRPASGRSQPGRSPPPPPPPEPSDMPCADDECFSGDGTTPLVALPTLATQAEARPLIKVKQLTQNSATITVQLPSPFHRMYTLEHFNNSKASTVSRLTKAQEEIRLTNLFTLTNYTYCVVSTSAGLRHNHTCLTICLPRLPSPPGPVPSPSTATHYIMTILGCLFGMVLVLGAVYYCLRRRRRQEEKHKKAASAAAAGSLKKTIIELKYGPELEAPGLAPLSQGPLLGPEAVTRIPYLPAAGEVEQYKLVESADTPKASKGSYMEVRTGDPPERRDCELGRPGPDSQSSVAEISTIAKEVDKVNQIINNCIDALKSESTSFQGVKSGPVSVAEPPLVLLSEPLAAKHGFLAPGYKDAFGHSLQRHHSVEAAGPPRASTSSSGSVRSPRAFRAEAVGVHKAAAAEAKYIEKGSPAADAILTVTPAAAVLRAEAEKGRQYGEHRHSYPGSHPAEPPAPPGPPPPPPHEGLGRKASILEPLTRPRPRDLAYSQLSPQYHSLSYSSSPEYTCRASQSIWERFRLSRRRHKEEEEFMAAGHALRKKVQFAKDEDLHDILDYWKGVSAQHKS"},{"id":"SEQ_01535","a":"Q15149","g":"PLEC","d":"Plectin","L":4684,"m":[{"c":"xGφxDPxxxxxφ[STP]φxx[AL]φx+GφφxxxxxxxLLxAxxx(x){0,1}","u":"37-38","sp":"tandem","x":"structured_like","cf":"high","why":"31 copies of a highly conserved 38-aa structural repeat (30 of 38 aa, 1 of 37 aa) arranged into six head-to-tail 5-repeat tandem arrays plus one solo repeat across the C-terminal region, anchored by a DP turn, [STP]φxx[AL]φx+Gφφ core, and C-terminal LLxA 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K/R-I-x-I-ψ-I β-strand.","i":[[3030,3102,"ELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEE"],[3359,3431,"EELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEE"],[3692,3765,"TQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEK"]]}],"s":"MVAGMLMPRDQLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMASLRARGLVRETFAWCHFYWYLTNEGIAHLRQYLHLPPEIVPASLQRVRRPVAMVMPARRTPHVQAVQGPLGSPPKRGPLPTEEQRVYRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA"},{"id":"SEQ_01550","a":"P98082","g":"DAB2","d":"Disabled 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GNPFA.","i":[[252,256,"ENPFL"],[292,296,"PDPFR"],[297,301,"DDPFT"],[395,399,"PNPFV"],[591,595,"GNPFQ"],[735,739,"ENPFF"],[766,770,"GNPFA"]]}],"s":"MSNEVETSATNGQPDQQAAPKAPSKKEKKKGPEKTDEYLLARFKGDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGMAAAGRSQGQHKQRIWVNISLSGIKIIDEKTGVIEHEHPVNKISFIARDVTDNRAFGYVCGGEGQHQFFAIKTGQQAEPLVVDLKDLFQVIYNVKKKEEEKKKIEEASKAVENGSEALMILDDQTNKLKSGVDQMDLFGDMSTPPDLNSPTESKDILLVDLNSEIDTNQNSLRENPFLTNGITSCSLPRPTPQASFLPENAFSANLNFFPTPNPDPFRDDPFTQPDQSTPSSFDSLKSPDQKKENSSSSSTPLSNGPLNGDVDYFGQQFDQISNRTGKQEAQAGPWPFSSSQTQPAVRTQNGVSEREQNGFSVKSSPNPFVGSPPKGLSIQNGVKQDLESSVQSSPHDSIAIIPPPQSTKPGRGRRTAKSSANDLLASDIFAPPVSEPSGQASPTGQPTALQPNPLDLFKTSAPAPVGPLVGLGGVTVTLPQAGPWNTASLVFNQSPSMAPGAMMGGQPSGFSQPVIFGTSPAVSGWNQPSPFAASTPPPVPVVWGPSASVAPNAWSTTSPLGNPFQSNIFPAPAVSTQPPSMHSSLLVTPPQPPPRAGPPKDISSDAFTALDPLGDKEIKDVKEMFKDFQLRQPPAVPARKGEQTSSGTLSAFASYFNSKVGIPQENADHDDFDANQLLNKINEPPKPAPRQVSLPVTKSTDNAFENPFFKDSFGSSQASVASSQPVSSEMYRDPFGNPFA"},{"id":"SEQ_01571","a":"Q9Y6X8","g":"ZHX2","d":"Zinc fingers and homeoboxes 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18.","i":[[78,102,"YECKYCPYSTQNLNEFTEHVDMQHP"],[110,134,"YVCAECNFTTKKYDSLSDHNSKFHP"]]}],"s":"MASKRKSTTPCMVRTSQVVEQDVPEEVDRAKEKGIGTPQPDVAKDSWAAELENSSKENEVIEVKSMGESQSKKLQGGYECKYCPYSTQNLNEFTEHVDMQHPNVILNPLYVCAECNFTTKKYDSLSDHNSKFHPGEANFKLKLIKRNNQTVLEQSIETTNHVVSITTSGPGTGDSDSGISVSKTPIMKPGKPKADAKKVPKKPEEITPENHVEGTARLVTDTAEILSRLGGVELLQDTLGHVMPSVQLPPNINLVPKVPVPLNTTKYNSALDTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISWSPEEVEEARKKMFNGTIQSVPPTITVLPAQLAPTKVTQPILQTALPCQILGQTSLVLTQVTSGSTTVSCSPITLAVAGVTNHGQKRPLVTPQAAPEPKRPHIAQVPEPPPKVANPPLTPASDRKKTKEQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQRGIVHITSESLAKDQLAIAASRHGRTYHAYPDFAPQKFKEKTQGQVKILEDSFLKSSFPTQAELDRLRVETKLSRREIDSWFSERRKLRDSMEQAVLDSMGSGKKGQDVGAPNGALSRLDQLSGAQLTSSLPSPSPAIAKSQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLKTGTVKWMEQYQHQPMADDHGYDAVARKATKPMAESPKNGGDVVPQYYKDPKKLCEEDLEKLVTRVKVGSEPAKDCLPAKPSEATSDRSEGSSRDGQGSDENEESSVVDYVEVTVGEEDAISDRSDSWSQAAAEGVSELAESDSDCVPAEAGQA"},{"id":"SEQ_01575","a":"E2RYF7","g":"HCG22","d":"Protein PBMUCL2","L":251,"m":[{"c":"[EK]xx[VI][TS][AV]D[PG][GRA]TT","u":11,"sp":"tandem","x":"disordered_like","cf":"high","why":"14 contiguous head-to-tail 11-aa tandem repeats in the C-terminal Thr/Pro/Asp-rich disordered region, strongly anchored by invariant D7 and T10-T11 plus conserved [EK]1, aliphatic [VI]4, [TS]5, [AV]6, and [PG]8-[GRA]9 positions.","i":[[85,95,"ENDVTADGRTT"],[96,106,"EDHITADPGTT"],[107,117,"EDSVTADPGTT"],[118,128,"EDNVTVDPGTT"],[129,139,"EGSVTADPATT"],[140,150,"KDYVSADPGTT"],[151,161,"KDSVTADPGTT"],[162,172,"ENFVTADPGTT"],[173,183,"KDSITADPRTT"],[184,194,"EDSVTADPGTT"],[195,205,"KHSITVDPGTT"],[206,216,"EDSVTADPGTT"],[217,227,"KHSITADPGTT"],[228,238,"EDSVTADPGTT"]]}],"s":"MPRYVPLLLLLLLLRCSERGGGVNFGEKDAKVPGTWRDGVRVPGEGASWDSDRASPERRYGIVGLSQSISTKHPETSPKDSRIRENDVTADGRTTEDHITADPGTTEDSVTADPGTTEDNVTVDPGTTEGSVTADPATTKDYVSADPGTTKDSVTADPGTTENFVTADPGTTKDSITADPRTTEDSVTADPGTTKHSITVDPGTTEDSVTADPGTTKHSITADPGTTEDSVTADPGTTEDETTKHGDTHLL"},{"id":"SEQ_01590","a":"Q8IV76","g":"PASD1","d":"Circadian clock protein PASD1","L":773,"m":[{"c":"+[MR]Q[EK]KKKLQE[QR]","u":11,"sp":"tandem","x":"mixed","cf":"high","why":"Three head-to-tail 11-aa repeats (including an exact tandem duplication of KMQEKKKLQEQ) anchored by invariant Q3 and KKKLQE (positions 5-10) with conserved basic N-termini inside the helical charged region.","i":[[514,524,"KMQEKKKLQEQ"],[525,535,"KMQEKKKLQEQ"],[536,546,"RRQKKKKLQER"]]},{"c":"[MA]D[PQ][VQ]D[PL]Ex[SP]V[DA]","u":11,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three closely spaced 11-aa acidic/proline-rich repeats in the central disordered region sharing invariant D2, D5, E7, and V10 anchors; copies 1 and 3 share DPVDxExSVD while copies 2 and 3 form part of a tandem 18-aa duplication (VDQEGPMDQQDPENPVAP / LDQAGLMDPVDPEDSVDL).","i":[[299,309,"ADPVDLEFSVD"],[320,330,"MDQQDPENPVA"],[338,348,"MDPVDPEDSVD"]]}],"s":"MKMRGEKRRDKVNPKSSQRKLNWIPSFPTYDYFNQVTLQLLDGFMITLSTDGVIICVAENISSLLGHLPAEIVGKKLLSLLPDEEKDEVYQKIILKFPLLNSETHIEFCCHLKRGNVEHGDSSAYENVKFIVNVRDICNEFPVVFSGLFSSHLCADFAACVPQEDRLYLVGNVCILRTQLLQQLYTSKAVSDEAVLTQDSDEEPFVGELSSSQGQRGHTSMKAVYVEPAAAAAAAAISDDQIDIAEVEQYGPQENVHMFVDSDSTYCSSTVFLDTMPESPALSLQDFRGEPEVNPLYRADPVDLEFSVDQVDSVDQEGPMDQQDPENPVAPLDQAGLMDPVDPEDSVDLGAAGASAQPLQPSSPVAYDIISQELELMKKLKEQLEERTWLLHDAIQNQQNALELMMDHLQKQPNTLRHVVIPDLQSSEAVPKKQQKQHAGQVKRPLPHPKDVKCFCGLSLSNSLKNTGELQEPCVAFNQQQLVQQEQHLKEQQRQLREQLQQLREQRKVQKQKKMQEKKKLQEQKMQEKKKLQEQRRQKKKKLQERKKWQGQMLQKEPEEEQQKQQLQEQPLKHNVIVGNERVQICLQNPRDVSVPLCNHPVRFLQAQPIVPVQRAAEQQPSGFYQDENCGQQEDESQSFYPEAYQGPPVNQLPLIDTSNSEAISSSSIPQFPITSDSTISTLETPQDYIRLWQELSDSLGPVVQVNTWSCDEQGTLHGQPTYHQVQVSEVGVEGPPDPQAFQGPAAYQPDQMRSAEQTRLMPAEQRDSNKPC"},{"id":"SEQ_01596","a":"Q9NYV4","g":"CDK12","d":"Cyclin-dependent kinase 12","L":1490,"m":[{"c":"RS[PV]SPY[SG]RR","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three 9-aa motif copies in the N-terminal Arg/Ser/Pro-rich disordered region share 7 invariant anchor positions (R, S, S, P, Y, R, R) around a conserved SPY core with dibasic C-terminal flanking, separated by 1 and 13 residues.","i":[[290,298,"RSPSPYSRR"],[300,308,"RSVSPYSRR"],[322,330,"RSPSPYGRR"]]}],"s":"MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVPY"},{"id":"SEQ_01600","a":"Q14247","g":"CTTN","d":"Src substrate cortactin","L":550,"m":[{"c":"G[FY]GGK[FY]G[VI][EQD]x-+xDx[SCA]A[VL]G[FWH]-[YH][QK][SGE]K[LT]x[KL]H[CEA]SQxD[YS][SVK]x","u":37,"sp":"tandem","x":"mixed","cf":"high","why":"Six head-to-tail 37-aa tandem repeats (followed immediately by a truncated 7th N-terminal half-repeat GFGGKYGVQKDRMDK) with an invariant G[FY]GGK[FY]G[VI] N-terminal signature and a conserved A[VL]G[FWH]-[YH]...KHxSQxD C-terminal segment.","i":[[83,119,"GYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVR"],[120,156,"GFGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSS"],[157,193,"GFGGKYGVQADRVDKSAVGFDYQGKTEKHESQRDYSK"],[194,230,"GFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVK"],[231,267,"GFGGKFGVQTDRQDKCALGWDHQEKLQLHESQKDYKT"],[268,304,"GFGGKFGVQSERQDSAAVGFDYKEKLAKHESQQDYSK"]]},{"c":"[ES][PA]VY[ES]x[AE][AE][SA]","u":9,"sp":"periodic","x":"disordered_like","cf":"high","why":"Three periodically spaced 9-aa tyrosine-centered motifs (separated by 16-aa and 15-aa linkers) in the Pro/Glu/Ser-rich disordered linker share an invariant VY core flanked by N-terminal [ES][PA] and C-terminal Ala/Glu-rich positions.","i":[[418,426,"SPVYEDAAS"],[443,451,"EPVYSMEAA"],[467,475,"EAVYESAEA"]]}],"s":"MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRENVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRGFGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQGKTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSERQDSAAVGFDYKEKLAKHESQQDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKEKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPVYEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ"},{"id":"SEQ_01603","a":"P0CG12","g":"DERPC","d":"Decreased expression in renal and prostate cancer protein","L":524,"m":[{"c":"xxG[PL]xGx[NGS][PS]xx[FN]PR","u":14,"sp":"tandem","x":"disordered_like","cf":"high","why":"Extensive proline/glycine-rich 14-residue tandem repeat array spanning residues 54-508, anchored by conserved G at positions 3 and 6, [NGS][PS] at positions 8-9, and a C-terminal [FN]PR motif across long head-to-tail blocks separated by occasional length-variant/truncated repeat units.","i":[[54,67,"AAGSLGGNLTPFPR"],[75,88,"SSGSLASNPAPFPA"],[101,114,"GMNPTGTGAVSFPR"],[119,132,"LGPGPGPGPTLNPR"],[133,146,"TGALPGPGPLSNPR"],[147,160,"LGGLPGPGPMSNPR"],[173,186,"GGGPMGPGSGPNLR"],[226,239,"SGVFPGPGLGPNPR"],[253,266,"AGGLLGTGSGLNLR"],[267,280,"MAGPQGLDLAPILR"],[281,294,"AAGLLGANSASFSQ"],[295,308,"ASGNMGTSPSSMAR"],[309,322,"VPGPMGPNSGPSSR"],[323,336,"GIGLPGPNPSPMSR"],[337,350,"APGPIGPNSAHFSR"],[351,364,"PVGPMGVNANPFPR"],[374,387,"SSGTLASNPATFQR"],[388,401,"SAGLQGSNPTIFPR"],[402,415,"ASGPLGPNPANFPR"],[416,429,"ATGLQGPSPTTFPR"],[430,443,"STGPLGPGQVTFPR"],[453,466,"PAGPVGINPAPFTR"],[467,480,"PTGTLGLNPASFPR"],[481,494,"MNGPAGKSFVPFPR"],[495,508,"VGSLPGTNPAAFPR"]]}],"s":"MKEPRIFPRERPTPWTRAPLPPRGRLDGSLGPQGGPVLNTGHPLGVNSDPFLMAAGSLGGNLTPFPRNPSPFPASSGSLASNPAPFPAGARDPSMASFPRGMNPTGTGAVSFPRPGGLLGPGPGPGPTLNPRTGALPGPGPLSNPRLGGLPGPGPMSNPRAGGLLGAGPDPRGGGPMGPGSGPNLRAGVLLTSGNGPPNPRPVGLGPGPNPNLRSGFLGTNPAPRSGVFPGPGLGPNPRPSGLGPGPNLDARAGGLLGTGSGLNLRMAGPQGLDLAPILRAAGLLGANSASFSQASGNMGTSPSSMARVPGPMGPNSGPSSRGIGLPGPNPSPMSRAPGPIGPNSAHFSRPVGPMGVNANPFPRGAGSSAFSQSSGTLASNPATFQRSAGLQGSNPTIFPRASGPLGPNPANFPRATGLQGPSPTTFPRSTGPLGPGQVTFPRPAAGHLGPSPAGPVGINPAPFTRPTGTLGLNPASFPRMNGPAGKSFVPFPRVGSLPGTNPAAFPRPGGPMAAMYPNGMLPP"},{"id":"SEQ_01605","a":"O60281","g":"ZNF292","d":"Zinc finger protein 292","L":2723,"m":[{"c":"xxC(x){2,4}Cxxxφ(x){4,5}φxxH(x){3,4}H","u":"22-26","sp":"dispersed","x":"structured_like","cf":"high","why":"Fifteen canonical Cys2-His2 repeats distributed across multiple clusters and separated by variable linkers, each anchored by invariant C-x(2,4)-C and H-x(3,4)-H metal-chelating pairs, a frequent N-terminal aromatic residue (F/Y in 12/15 copies), and two strictly conserved internal hydrophobic core positions.","i":[[542,563,"QYCVLCDKEFLGHRIVRHAQKH"],[569,591,"YSCPICAKNFNSKETFVPHVTLH"],[681,705,"FNCPVTFCKKGFKYFKNLIAHVKGH"],[722,744,"VICQYCRRHFVSVTHLNDHLQMH"],[750,774,"YICIQMKCKAGFNSYAELLTHRKEH"],[779,803,"AKCMFPKCGRIFSEAYLLYDHEAQH"],[807,831,"YTCKFTGCGKVYRSQGELEKHLDDH"],[1098,1123,"FSCQVEGCTRTYNSSQSIGKHMKTAH"],[1902,1927,"FVCQNQGCNYSAMTKDALFKHYGKIH"],[1947,1972,"FKCVVPTCTKTFTRNSNLRAHCQLVH"],[2114,2139,"YRCVHQGCFAAFTIQQNLILHYQAVH"],[2172,2197,"FRCQVSDCSRIFQAITGLIQHYMKLH"],[2216,2241,"FPCDQLECKSSFTTYLNYVVHLEADH"],[2256,2281,"YKCDCEGCDRIYATRSNLLRHIFNKH"],[2386,2410,"YPCMIKGCTSVVTSESNIIRHYKCH"]]}],"s":"MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQTLLEYAEKWKTSEDPLPLLEVYTVAIQSYVKARPYLTSECENVALVLERLALSCVELLLCLPVELSDKQWEQFQTLVQVAHEKLMENGSCELHFLATLAQETGVWKNPVLCTILSQEPLDKDKVNEFLAFEGPILLDMRIKHLIKTNQLSQATALAKLCSDHPEIGIKGSFKQTYLVCLCTSSPNGKLIEEISEVDCKDALEMICNLESEGDEKSALVLCTAFLSRQLQQGDMYCAWELTLFWSKLQQRVEPSIQVYLERCRQLSLLTKTVYHIFFLIKVINSETEGAGLATCIELCVKALRLESTENTEVKISICKTISCLLPDDLEVKRACQLSEFLIEPTVDAYYAVEMLYNQPDQKYDEENLPIPNSLRCELLLVLKTQWPFDPEFWDWKTLKRQCLALMGEEASIVSSIDELNDSEVYEKVVDYQEESKETSMNGLSGGVGANSGLLKDIGDEKQKKREIKQLRERGFISARFRNWQAYMQYCVLCDKEFLGHRIVRHAQKHYKDGIYSCPICAKNFNSKETFVPHVTLHVKQSSKERLAAMKPLRRLGRPPKITTTNENQKTNTVAKQEQRPIKKNSLYSTDFIVFNDNDGSDDENDDKDKSYEPEVIPVQKPVPVNEFNCPVTFCKKGFKYFKNLIAHVKGHKDNEDAKRFLEMQSKKVICQYCRRHFVSVTHLNDHLQMHCGSKPYICIQMKCKAGFNSYAELLTHRKEHQVFRAKCMFPKCGRIFSEAYLLYDHEAQHYNTYTCKFTGCGKVYRSQGELEKHLDDHSTPPEKVLPPEAQLNSSGDSIQPSEVNQNTAENIEKERSMLPSENNIENSLLADRSDAWDKSKAESAVTKQDQISASELRQANGPLSNGLENPATTPLLQSSEVAVSIKVSLNQGIEDNFGKQENSTVEGSGEALVTDLHTPVEDTCNDLCHPGFQERKEQDCFNDAHVTQNSLVNSETLKIGDLTPQNLERQVNNLMTFSVQNQAAFQNNLPTSKFECGDNVKTSSNLYNLPLKTLESIAFVPPQSDLSNSLGTPSVPPKAPVQKFSCQVEGCTRTYNSSQSIGKHMKTAHPDQYAAFKMQRKSKKGQKANNLNTPNNGKFVYFLPSPVNSSNPFFTSQTKANGNPACSAQLQHVSPPIFPAHLASVSTPLLSSMESVINPNITSQDKNEQGGMLCSQMENLPSTALPAQMEDLTKTVLPLNIDSGSDPFLPLPAESSSMSLFPSPADSGTNSVFSQLENNTNHYSSQIEGNTNSSFLKGGNGENAVFPSQVNVANNFSSTNAQQSAPEKVKKDRGRGPNGKERKPKHNKRAKWPAIIRDGKFICSRCYRAFTNPRSLGGHLSKRSYCKPLDGAEIAQELLQSNGQPSLLASMILSTNAVNLQQPQQSTFNPEACFKDPSFLQLLAENRSPAFLPNTFPRSGVTNFNTSVSQEGSEIIKQALETAGIPSTFEGAEMLSHVSTGCVSDASQVNATVMPNPTVPPLLHTVCHPNTLLTNQNRTSNSKTSSIEECSSLPVFPTNDLLLKTVENGLCSSSFPNSGGPSQNFTSNSSRVSVISGPQNTRSSHLNKKGNSASKRRKKVAPPLIAPNASQNLVTSDLTTMGLIAKSVEIPTTNLHSNVIPTCEPQSLVENLTQKLNNVNNQLFMTDVKENFKTSLESHTVLAPLTLKTENGDSQMMALNSCTTSINSDLQISEDNVIQNFEKTLEIIKTAMNSQILEVKSGSQGAGETSQNAQINYNIQLPSVNTVQNNKLPDSSPFSSFISVMPTKSNIPQSEVSHKEDQIQEILEGLQKLKLENDLSTPASQCVLINTSVTLTPTPVKSTADITVIQPVSEMINIQFNDKVNKPFVCQNQGCNYSAMTKDALFKHYGKIHQYTPEMILEIKKNQLKFAPFKCVVPTCTKTFTRNSNLRAHCQLVHHFTTEEMVKLKIKRPYGRKSQSENVPASRSTQVKKQLAMTEENKKESQPALELRAETQNTHSNVAVIPEKQLVEKKSPDKTESSLQVITVTSEQCNTNALTNTQTKGRKIRRHKKEKEEKKRKKPVSQSLEFPTRYSPYRPYRCVHQGCFAAFTIQQNLILHYQAVHKSDLPAFSAEVEEESEAGKESEETETKQTLKEFRCQVSDCSRIFQAITGLIQHYMKLHEMTPEEIESMTASVDVGKFPCDQLECKSSFTTYLNYVVHLEADHGIGLRASKTEEDGVYKCDCEGCDRIYATRSNLLRHIFNKHNDKHKAHLIRPRRLTPGQENMSSKANQEKSKSKHRGTKHSRCGKEGIKMPKTKRKKKNNLENKNAKIVQIEENKPYSLKRGKHVYSIKARNDALSECTSRFVTQYPCMIKGCTSVVTSESNIIRHYKCHKLSKAFTSQHRNLLIVFKRCCNSQVKETSEQEGAKNDVKDSDTCVSESNDNSRTTATVSQKEVEKNEKDEMDELTELFITKLINEDSTSVETQANTSSNVSNDFQEDNLCQSERQKASNLKRVNKEKNVSQNKKRKVEKAEPASAAELSSVRKEEETAVAIQTIEEHPASFDWSSFKPMGFEVSFLKFLEESAVKQKKNTDKDHPNTGNKKGSHSNSRKNIDKTAVTSGNHVCPCKESETFVQFANPSQLQCSDNVKIVLDKNLKDCTELVLKQLQEMKPTVSLKKLEVHSNDPDMSVMKDISIGKATGRGQY"},{"id":"SEQ_01627","a":"Q6ZW76","g":"ANKS3","d":"Ankyrin repeat and SAM domain-containing protein 3","L":656,"m":[{"c":"xGxT[PA][LR][MF]x[AC]xxxG[HN]xxψ[VA]xφφxxx[GS]xxφxxxxx","u":33,"sp":"tandem","x":"structured_like","cf":"high","why":"Five tandem 33-aa structured repeats (head-to-tail with a single 1-aa linker between copies 3 and 4) defined by invariant G2, T4, and G13 anchors, a conserved [PA][LR][MF]x[AC] turn/helix signature, and a [HN]xxψ[VA]xφφ hydrophobic core, with C-terminal tail divergence as the fifth copy transitions into the disordered linker.","i":[[68,100,"GGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTP"],[101,133,"EGQTPLMLASSCGNESIAYFLLQQGAELEMKDI"],[134,166,"QGWTALFHCTSAGHQHMVRFLLDSGANANVREP"],[168,200,"CGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDH"],[201,233,"SGATARMLAKQYGHMKIVALMDTYSPSLPKSLY"]]}],"s":"MSELSDEASEPELLNRSLSMWHGLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMDTYSPSLPKSLYRSPEKYEDLSSSDESCPAPQRQRPCRKKGVSIHEGPRALARITGIGLGGRAPRPRYEQAPPRGYVTFNSSGENPLEEEGLCCRDVTSPINERDVESSSSSSSREEHAFCANLGPVQSSSSSEGLARAQGLSSEASVESNEDSDHACKSSARKQAKSYMKTKNPDSQWPPRAATDREGFLAESSPQTQRAPYSGPQDLAALLEQIGCLKYLQVFEEQDVDLRIFLTLTESDLKEIGITLFGPKRKMTSAIARWHSSARPPGDALELAYADRLEAEMQELAIQLHKRCEEVEATRGQVCQEQELRAVVESCLLEQDRAREDLQARLRETWALARDAALVLDQLRACQAELSSRVRQDQPPGAATLGLAVPPADSKGWQASLQAMSLPELSGALEDRVREMGQALCLVTQSLEKLQVLNGKKWRET"},{"id":"SEQ_01697","a":"Q5JRC9","g":"FAM47A","d":"Protein FAM47A","L":791,"m":[{"c":"[LR]xψLK(x){0,1}LD[PS][EG]RxL[EK]Dφ[WR][AD]xCEx[QR][EV]K[TK]Tx[EV]PTEP[GH]KxPCG[EK][FP]C","u":"41-42","sp":"dispersed","x":"structured_like","cf":"high","why":"Three strongly conserved 41-42 aa internal duplications anchored by N-terminal ψLK(x){0,1}LD...RxLxD motifs and a C-terminal CExxxKTTxxPTEPxKxPCGxxC cysteine-proline cluster, separated by arrays of short proline-rich repeats.","i":[[147,188,"LQVLKHLDPERELEDAWACCETQEKTTEVPTEPGKHPCGEFC"],[262,302,"RQLLKLDSERKLEDARAPCEGREKTTDEPTEPGKYPCGKFC"],[426,467,"LYILKVLDSGRTLKDVWDRCEARVKKTKEPTEPHKSPCGEPC"]]},{"c":"xxP[PSF][EK][TA]x[VEL][SC][HSR]xx","u":12,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Fourteen 12-aa disordered repeat units organized in tandem runs interspersed with 13-aa basic repeats and the 41-42 aa cysteine-rich modules, conserved around a xEPP[EK]TxVS[HS]Lx core.","i":[[189,200,"LKPPETPVSHLL"],[201,212,"PEPPETGVSHLS"],[213,224,"PEPPKTPVSSLR"],[225,236,"PEPPETGVSHLR"],[237,248,"PEPPETGVSHIR"],[303,314,"PRPFETPLSHLR"],[315,326,"QEPPKTPVSSLR"],[327,338,"PEPPETGESHLR"],[352,363,"SEPSETGVSRLR"],[377,388,"AEPSKTGVSHLS"],[389,400,"PEPPKTEVSHLH"],[401,412,"PVPPKTGVCHLR"],[468,479,"LQPPETQVSHPH"],[558,569,"PEPPKAPESHQF"]]},{"c":"[PSL]x[PHL][PS][KI][TS]RRxSSLx","u":13,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Nine 13-aa disordered repeats (including six consecutive head-to-tail copies at residues 480-557 and three earlier intercalated copies) anchored by an invariant RRxSSL C-terminal motif preceded by a proline-rich [KI][TS] segment.","i":[[249,261,"PGPPITRRRSSLL"],[339,351,"LEHSKTRRGSSLR"],[364,376,"LAPPKTRRGSSLH"],[480,492,"PEHPKTRRRSSLH"],[493,505,"SQPPKTRRTSSLR"],[506,518,"SEPPKTRRTSSLR"],[519,531,"SEPPKTRRTSSLG"],[532,544,"PEPPKTRRVSSLR"],[545,557,"PELPKSRRVSSLH"]]}],"s":"MGDQRLQDWLRSPGMDSKPWYCNKRPSKCFAKCKHRRLRFPPMDTQNWVFVKEGMDDFRYGCPSPEDTLVCRRDEFLLPKISLRGPQADPKSGQKKLLKKAALFSKLSPAQLARKAFVEQVEAQLMAKHPLAMYPNLGEDMPPDLLLQVLKHLDPERELEDAWACCETQEKTTEVPTEPGKHPCGEFCLKPPETPVSHLLPEPPETGVSHLSPEPPKTPVSSLRPEPPETGVSHLRPEPPETGVSHIRPGPPITRRRSSLLRQLLKLDSERKLEDARAPCEGREKTTDEPTEPGKYPCGKFCPRPFETPLSHLRQEPPKTPVSSLRPEPPETGESHLRLEHSKTRRGSSLRSEPSETGVSRLRLAPPKTRRGSSLHAEPSKTGVSHLSPEPPKTEVSHLHPVPPKTGVCHLRLEPPDTSQVSNLLLYILKVLDSGRTLKDVWDRCEARVKKTKEPTEPHKSPCGEPCLQPPETQVSHPHPEHPKTRRRSSLHSQPPKTRRTSSLRSEPPKTRRTSSLRSEPPKTRRTSSLGPEPPKTRRVSSLRPELPKSRRVSSLHPEPPKAPESHQFSEPPKIRASYIKELLQEDTPSTKECVSDSLQYRYTSEKLREFFKWAGDLGADEESIRNLFDFTPKYRATHEDQKFKKVKECSSELKYSMELDEKDEDKFFSQEKYWGRKFHTPSNSYTAQRVKMKYGAWYLKPKLWKKLRSDEPLIDPKLLLKKPDEPDVLDDLYGPIAFKDFILSKGYEMPGIIQRLFARRGWTYDSVKTPIQRAMIFYKYKEIVEASEED"},{"id":"SEQ_01698","a":"Q86YJ7","g":"ANKRD13B","d":"Ankyrin repeat domain-containing protein 13B","L":626,"m":[{"c":"G[KRW][YT][PV]L[HQ](x){7,10}LExx[VRQ](x){13,15}","u":"33-34","sp":"tandem","x":"structured_like","cf":"medium","why":"Three head-to-tail 33-34 aa N-terminal repeats sharing an invariant initial G[KRW][YT][PV]L[HQ] turn/cap motif and a conserved downstream LExx[VRQ] amphipathic segment.","i":[[14,47,"GKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPR"],[48,80,"GRTPLHLATTLGHLECARVLLAHGADVGRENRS"],[81,113,"GWTVLQEAVSTRDLELVQLVLRYRDYQRVVKRL"]]}],"s":"MIPANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRDYQRVVKRLAGIPVLLEKLRKAQDFYVEMKWEFTSWVPLVSKICPSDTYKVWKSGQNLRVDTTLLGFDHMTWQRGNRSFVFRGQDTSAVVMEIDHDRRVVYTETLALAGQDRELLLAAAQPTEEQVLSRLTAPVVTTQLDTKNISFERNKTGILGWRSEKTEMVNGYEAKVYGASNVELITRTRTEHLSEQHKGKVKGCKTPLQSFLGIAEQHGGPQNGTLITQTLSQANPTAITAEEYFNPNFELGNRDMGRPMELTTKTQKFKAKLWLCEEHPLSLCEQVAPIIDLMAVSNALFAKLRDFITLRLPPGFPVKIEIPIFHILNARITFGNLNGCDEPVPSVRGSPSSETPSPGSDSSSVSSSSSTTSCRGCEISPALFEAPRGYSMMGGQREAATRDDDDDLLQFAIQQSLLEAGSEYDQVTIWEALTNSKPGTHPMSYEGRRQDRSAPPTPQRQPAPPASVPSPRPSSGPGSGGHVFRSYDEQLRLAMELSAQEQEERRRRARQEEEELERILRLSLTEQ"},{"id":"SEQ_01700","a":"Q9Y483","g":"MTF2","d":"Metal-response element-binding transcription factor 2","L":593,"m":[{"c":"Cxxx[CQ]xxxxxxxxxMψ[IQ]CxKC[GK]Q[GW]ΩH[QE]φC(x){15,16}[WF]ψCxxC","u":"50-51","sp":"dispersed","x":"structured_like","cf":"high","why":"Two dispersed 50-51 aa cysteine/histidine-rich duplications with highly conserved multi-position architecture, including aligned CxxC/CxCxC pairs, an Mψ[IQ]CxKC[GK]Q[GW]ΩH[QE]φC core, and a C-terminal [WF]ψCxxC motif.","i":[[105,154,"CTICQEEYSEAPNEMVICDKCGQGYHQLCHTPHIDSSVIDSDEKWLCRQC"],[202,252,"CYCYCGGPGDWYLKMLQCCKCKQWFHEACVQCLQKPMLFGDRFYTFICSVC"]]}],"s":"MRDSTGAGNSLVHKRSPLRRNQKTPTSLTKLSLQDGHKAKKPACKFEEGQDVLARWSDGLFYLGTIKKINILKQSCFIIFEDSSKSWVLWKDIQTGATGSGEMVCTICQEEYSEAPNEMVICDKCGQGYHQLCHTPHIDSSVIDSDEKWLCRQCVFATTTKRGGALKKGPNAKALQVMKQTLPYSVADLEWDAGHKTNVQQCYCYCGGPGDWYLKMLQCCKCKQWFHEACVQCLQKPMLFGDRFYTFICSVCSSGPEYLKRLPLQWVDIAHLCLYNLSVIHKKKYFDSELELMTYINENWDRLHPGELADTPKSERYEHVLEALNDYKTMFMSGKEIKKKKHLFGLRIRVPPVPPNVAFKAEKEPEGTSHEFKIKGRKASKPISDSREVSNGIEKKGKKKSVGRPPGPYTRKMIQKTAEPLLDKESISENPTLDLPCSIGRTEGTAHSSNTSDVDFTGASSAKETTSSSISRHYGLSDSRKRTRTGRSWPAAIPHLRRRRGRLPRRALQTQNSEIVKDDEGKEDYQFDELNTEILNNLADQELQLNHLKNSITSYFGAAGRIACGEKYRVLARRVTLDGKVQYLVEWEGATAS"},{"id":"SEQ_01705","a":"Q3KP44","g":"ANKRD55","d":"Ankyrin repeat domain-containing protein 55","L":614,"m":[{"c":"Dxxxx[TL]x[LV]xxA(x){10,11}[LI][LA](x){9,12}","u":"32-36","sp":"tandem","x":"structured_like","cf":"high","why":"Eight head-to-tail 32-36 aa structured repeats (residues 58-326) anchored by an invariant N-terminal Asp turn, a conserved [TL]x[LV]xxA core motif (predominantly GxTPLHxAA), and a second hydrophobic [LI][LA] pair followed by a 9-12 aa linker.","i":[[58,90,"DSEGCTPLMHAVSGRQADTVKLLLKMGANINMQ"],[91,123,"DAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIP"],[124,158,"DKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQ"],[159,191,"DNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLV"],[192,227,"DKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYD"],[228,261,"DESGKTCVHIAAAAGFSDIIHELARVPECNLQAL"],[262,294,"DVDDRTPLHWAAAAGKAECVQSLLELGMDSNLR"],[295,326,"DINESTPLAYALYCGHTACVKLLSQESRTEPT"]]}],"s":"MMRQATMDFSTPSVFDQQRGDSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSQESRTEPTRPPPSQSSRPQKKERRFNVLNQIFCKNKKEEQRAHQKDPSRDRYREEDTSEVNDIITTFDSIVGTNCQEQPGDQVAMVEFKKKTSDNSKYLLPEKKPLARKGLPPIRTQSLPPITLGNNFLTASHRATSHAGLSSAPHHMAQRSQKSRSEQDLLNNRTGCQMLLDNPWKSDSNQVFSYKVWTVSSSDKLLDRLLSVRPGHQEVSVPPHLRHLHNPSSGQNFQHLSPNRHKIRDLPFTRNNLAPLPDQKFLSGEPLRTNRVLPAIPSQRRHSTAAEESEHSANPTSDEN"},{"id":"SEQ_01712","a":"O75376","g":"NCOR1","d":"Nuclear receptor corepressor 1","L":2440,"m":[{"c":"G[SA]I[STM]xG[TLK]P","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Seven dispersed 8-residue motif copies in the central Pro/Ser-rich disordered region (residues 1056-1387) anchored by four invariant positions (G1, I3, G6, P8) and three tightly constrained positions ([SA]2, [STM]4, [TLK]7).","i":[[1055,1062,"GSISQGTP"],[1084,1091,"GSISLGLP"],[1142,1149,"GSITRGTP"],[1163,1170,"GSITQGTP"],[1294,1301,"GSIMQGTP"],[1330,1337,"GAITKGKP"],[1380,1387,"GSISQGTP"]]},{"c":"WT-xExEψφKxxφψxHx+NΩ[GA]φIAxφψxxKSxxxCxxΩYΩxxK+xxNφxxLψ","u":52,"sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of a 52-residue structured helical domain (residues 441-492 and 629-680) with gapless conservation across 16 identical anchors (WT, E, E, K, H, N, IA, KS, C, Y, K, N, L) and 14 conserved hydrophobic/aromatic/charged core positions.","i":[[440,491,"WTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYYLTKKNENYKALV"],[628,679,"WTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLL"]]},{"c":"ITφAxxIxxIITxxφA","u":16,"sp":"dispersed","x":"mixed","cf":"medium","why":"Two dispersed 16-residue hydrophobic/helical-like islands embedded within the C-terminal disordered region (residues 1927-1942 and 2049-2064), sharing 8 identical anchor residues (IT, A, I, IIT, A) and flanking hydrophobic positions.","i":[[1927,1942,"ITAANFIDVIITRQIA"],[2049,2064,"ITLADHICQIITQDFA"]]}],"s":"MSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRPQERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRASADAKKDPAFGGKHEAPSSPISGQPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRKKAEEAHKIFEGLGPKVELPLYNQPSDTKVYHENIKTNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIRKQREQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRGRNQQIARPSQEEKVEEKEEDKAEKTEKKEEEKKDEEEKDEKEDSKENTKEKDKIDGTAEETEEREQATPRGRKTANSQGRRKGRITRSMTNEAAAASAAAAAATEEPPPPLPPPPEPISTEPVETSRWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCESVASTVSAQEDEDIEASNEEENPEDSEVEAVKPSEDSPENATSRGNTEPAVELEPTTETAPSTSPSLAVPSTKPAEDESVETQVNDSISAETAEQMDVDQQEHSAEEGSVCDPPPATKADSVDVEVRVPENHASKVEGDNTKERDLDRASEKVEPRDEDLVVAQQINAQRPEPQSDNDSSATCSADEDVDGEPERQRMFPMDSKPSLLNPTGSILVSSPLKPNPLDLPQLQHRAAVIPPMVSCTPCNIPIGTPVSGYALYQRHIKAMHESALLEEQRQRQEQIDLECRSSTSPCGTSKSPNREWEVLQPAPHQVITNLPEGVRLPTTRPTRPPPPLIPSSKTTVASEKPSFIMGGSISQGTPGTYLTSHNQASYTQETPKPSVGSISLGLPRQQESAKSATLPYIKQEEFSPRSQNSQPEGLLVRAQHEGVVRGTAGAIQEGSITRGTPTSKISVESIPSLRGSITQGTPALPQTGIPTEALVKGSISRMPIEDSSPEKGREEAASKGHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEISLKRSYESVEGNIKQGMSMRESPVSAPLEGLICRALPRGSPHSDLKERTVLSGSIMQGTPRATTESFEDGLKYPKQIKRESPPIRAFEGAITKGKPYDGITTIKEMGRSIHEIPRQDILTQESRKTPEVVQSTRPIIEGSISQGTPIKFDNNSGQSAIKHNVKSLITGPSKLSRGMPPLEIVPENIKVVERGKYEDVKAGETVRSRHTSVVSSGPSVLRSTLHEAPKAQLSPGIYDDTSARRTPVSYQNTMSRGSPMMNRTSDVTISSNKSTNHERKSTLTPTQRESIPAKSPVPGVDPVVSHSPFDPHHRGSTAGEVYRSHLPTHLDPAMPFHRALDPAAAAYLFQRQLSPTPGYPSQYQLYAMENTRQTILNDYITSQQMQVNLRPDVARGLSPREQPLGLPYPATRGIIDLTNMPPTILVPHPGGTSTPPMDRITYIPGTQITFPPRPYNSASMSPGHPTHLAAAASAEREREREREKERERERIAAASSDLYLRPGSEQPGRPGSHGYVRSPSPSVRTQETMLQQRPSVFQGTNGTSVITPLDPTAQLRIMPLPAGGPSISQGLPASRYNTAADALAALVDAAASAPQMDVSKTKESKHEAARLEENLRSRSAAVSEQQQLEQKTLEVEKRSVQCLYTSSAFPSGKPQPHSSVVYSEAGKDKGPPPKSRYEEELRTRGKTTITAANFIDVIITRQIASDKDARERGSQSSDSSSSLSSHRYETPSDAIEVISPASSPAPPQEKLQTYQPEVVKANQAENDPTRQYEGPLHHYRPQQESPSPQQQLPPSSQAEGMGQVPRTHRLITLADHICQIITQDFARNQVSSQTPQQPPTSTFQNSPSALVSTPVRTKTSNRYSPESQAQSVHHQRPGSRVSPENLVDKSRGSRPGKSPERSHVSSEPYEPISPPQVPVVHEKQDSLLLLSQRGAEPAEQRNDARSPGSISYLPSFFTKLENTSPMVKSKKQEIFRKLNSSGGGDSDMAAAQPGTEIFNLPAVTTSGSVSSRGHSFADPASNLGLEDIIRKALMGSFDDKVEDHGVVMSQPMGVVPGTANTSVVTSGETRREEGDPSPHSGGVCKPKLISKSNSRKSKSPIPGQGYLGTERPSSVSSVHSEGDYHRQTPGWAWEDRPSSTGSTQFPYNPLTMRMLSSTPPTPIACAPSAVNQAAPHQQNRIWEREPAPLLSAQYETLSDSDD"},{"id":"SEQ_01714","a":"Q8NBF1","g":"GLIS1","d":"Zinc finger protein GLIS1","L":620,"m":[{"c":"Cxxx[GD]Cxx[AR][FY](x){0,3}xxxxx[LR]x[RKI]H(x){3,4}H","u":"23-26","sp":"periodic","x":"structured_like","cf":"high","why":"Five periodic 23-26 aa repeats separated by regular 7-10 aa linkers, anchored by invariant C-x4-C and H-x(3,4)-H pairs along with conserved internal [GD], [AR], aromatic [FY], and [LR]x[RKI] positions.","i":[[197,220,"CRWVDCCAAYEQQEELVRHIEKSH"],[231,256,"CFWAGCVRRYKPFNARYKLLIHMRVH"],[264,286,"CMFEGCSKAFSRLENLKIHLRSH"],[294,316,"CQHPGCQKAFSNSSDRAKHQRTH"],[324,346,"CQIPGCSKRYTDPSSLRKHVKAH"]]}],"s":"MAEARTSLSAHCRGPLATGLHPDLDLPGRSLATPAPSCYLLGSEPSSGLGLQPETHLPEGSLKRCCVLGLPPTSPASSSPCASSDVTSIIRSSQTSLVTCVNGLRSPPLTGDLGGPSKRARPGPASTDSHEGSLQLEACRKASFLKQEPADEFSELFGPHQQGLPPPYPLSQLPPGPSLGGLGLGLAGRVVAGRQACRWVDCCAAYEQQEELVRHIEKSHIDQRKGEDFTCFWAGCVRRYKPFNARYKLLIHMRVHSGEKPNKCMFEGCSKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCSKRYTDPSSLRKHVKAHSAKEQQVRKKLHAGPDTEADVLTECLVLQQLHTSTQLAASDGKGGCGLGQELLPGVYPGSITPHNGLASGLLPPAHDVPSRHHPLDATTSSHHHLSPLPMAESTRDGLGPGLLSPIVSPLKGLGPPPLPPSSQSHSPGGQPFPTLPSKPSYPPFQSPPPPPLPSPQGYQGSFHSIQSCFPYGDCYRMAEPAAGGDGLVGETHGFNPLRPNGYHSLSTPLPATGYEALAEASCPTALPQQPSEDVVSSGPEDCGFFPNGAFDHCLGHIPSIYTDT"},{"id":"SEQ_01715","a":"Q5T1B0","g":"AXDND1","d":"Axonemal dynein light chain domain-containing protein 1","L":1012,"m":[{"c":"φxxψxxxxxxWxxφ","u":14,"sp":"periodic","x":"structured_like","cf":"medium","why":"Six consecutive periodic 14 aa amphipathic helical cores spaced every 28-33 residues (14-19 aa linkers), each anchored by an invariant tryptophan (W) flanked in helical register by conserved hydrophobic positions at -10 (φ), -7 (ψ), and +3 (φ).","i":[[390,403,"MKKLVAERDIWSSA"],[420,433,"ARRLYLNEKGWNKY"],[449,462,"LALLQKLTQKWRNL"],[481,494,"LKIVKDGLIKWQEF"],[509,522,"FNSVLLDFKQWQKI"],[542,555,"LKIIKHLQENWADI"]]}],"s":"MSLPKTPSTPLNSTSTSESKKLKVSVAKEGTRGLPELKEKKNMVDRSKLLPTSLQNEFIPKEVLLSLTYAANAGPCPENLLPPKKIKTPKGTLPRLVDHVWHHPVRRNKFKYLIDHPVSLTGAGRDISFLYDVTYAKGQTREKAVCPPHLARSLQSHDGVIVPHKPKTLTDTLIPEEFHIVSSTGVSGLECYDDKYTTLLTDSENRLLLFPSMKPNKRVEVAQLNDVMDTMLERAGVENQEYTGPTKMHKLLHILKKEQTIYNMIFHELIRQVSVDCADRGELLSKVRERYVQMLDQIARQMIDFYKDLVTQRVMDQRILEELYNFKHVIEELTRELCLVRAHDVKLTKETEKAHKDLAQALLNAEKNAKIVEEYHDLYTLQRERMENDMKKLVAERDIWSSATYELALKVIERNRVILARRLYLNEKGWNKYTKHFIILLSNKDTEDLALLQKLTQKWRNLVNKLKQEVEQMEESTSETLKIVKDGLIKWQEFFNEKDILSPNKGNIFNSVLLDFKQWQKILNEKKEEFTGDVLLSKYDTLKIIKHLQENWADIGLGIFNRHKSLEGEMPSERQYMEEIIKNIQKLYKEYEIRINGDNGYSKILPSLISSLDFCSFKLENLEFPDTPLEEWQEIDEKINEMKSHLDILLNLTGIVPQHIDVDSVSVLQAYIFNMIQQWLLKIGNEINNGNIELQHHMDELHISMIQWMVNLLILMIPNFTDQDCLLKLEEESAEKHDIGVARLELDAIELTRKLYQYSSYLSSCCKGMVTAMALSKSTNSHKNATEDLYEVDKLKKECYEWINTCSCLLSNIKGRKITLLTYEEIERLLEEEAVKEFIEPEIDESFKEDEEESKEDRKLQEENKERAEEQPSTSTEKEKLIRFIGEDENVHSKPLFETDVLSSWRESAKQGTLAQKYLEAMAVIEHMQEKLLEVENRARQAEEKFEDAYEKLHHTLIKNKDLEELVMTSRKESKEEKENQDEREVKEEEEQQEEEEVRSAENSSKSPKKGH"},{"id":"SEQ_01721","a":"Q5VZR2","g":"NUTM2G","d":"NUT family member 2G","L":741,"m":[{"c":"LPPP[RA]P[PQ]R","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three copies of an 8 aa proline-rich motif in the central disordered region anchored by invariant N-terminal L and C-terminal R plus constrained internal [RA]P[PQ] positions, with the second and third copies embedded in a head-to-tail 14 aa duplication (LPPPRP[PQ]RPAETK[AV]).","i":[[305,312,"LPPPAPPR"],[343,350,"LPPPRPQR"],[358,365,"LPPPRPPR"]]}],"s":"MASNGAYPVLGPGVTVNPGTSLSVFTALPFATPSPGPTHRPPLVTAVVPPAGPLVLSAFPSTPLVAGQDGRGPSGAGASNVFVQMRTEVGPVKPPQAQTLILTQAPLVWQAPGTLCGGVMCPPPLLLAAAPGVPVTSAQVVGGTQACEGGWSHGLPLPPPPPAAQVAPIVSPGNAGPWPQGAHGEGSLAPSQAKARPDDSCKPKSVYENFRLWQHYKPLARRHLPQSPDTEALSCFLIPVLRSLARRKPTMTLEEGLWRAMREWQHTSNFDRMIFYEMAAKFLEFEAEEEMQIQKSQWMKGPQSLPPPAPPRLEPRGPPAPEVVKQPVYLPSKDGPKAPTACLPPPRPQRPAETKAHLPPPRPPRPAETKVPEEIPPEVVQEYVDIMEELLGSHPGDTGEPEGQREKGKVEQPQEEDGMTSDPGLLSYIDKLCSQEDFVTKVEAVIHPRFLEELLSPDPQMDFLALSQELEQEEGLTLAQLVEKRLLSLKEKGCGRAAPRHGTARLDSSPSEFAAGQEAAREVPDPQQRVSVETSPPQTAAQDPQGQGRVRTGMARSEDPAVLLGCQDSPRLKAVRPTSPPQDHRPTCPGLGTKDALGLPGESPVKESHGLAKGSSEETELPGMVYVVGSHHRLRPWRLSQSPVPSSGLLSPGGRGPQGALQSPSAQKRGLSPSPSPASKSKKRPLFGSPSPAEKTPHPGPGLRVSGEQSLAWGLGGPSQSQKRKGDPLASRRKKKRHCSQ"},{"id":"SEQ_01726","a":"Q8TC41","g":"RNF217","d":"E3 ubiquitin-protein ligase RNF217","L":542,"m":[{"c":"CP[QK]CK(x){13,24}C[PS]oCoxxΩCΩ+CxxxΩ","u":"34-45","sp":"dispersed","x":"structured_like","cf":"high","why":"Two cysteine-rich zinc-binding domain repeats sharing an N-terminal CP[QK]CK knuckle, a variable 13-24 aa loop, and a strongly conserved 16-aa C[PS]oCoxxΩCΩ+CxxxΩ core with six invariant cysteines and three conserved aromatic positions.","i":[[346,390,"CPQCKHFTTFKKKGHIPTPSRSESKYKIQCPTCQFVWCFKCHSPW"],[423,456,"CPKCKIHIQRTEGCDHMTCSQCNTNFCYRCGERY"]]}],"s":"MGEEQSTVSGGGGPQESQTLASGTAGHPEPPRPQGDSARAPPLRAASAEPSGGGCGSDWGCADTSAPEPARSLGPPGWSKSRAPAQPAGLALTGPLNPQTLPLQLELEEEEEEAGDRKEGGDEQQEAPPGEELEPRTRVGAADGLVLDVLGQRRPSLAKRQVFCSVYCVESDLPEAPASEQLSPPASPPGAPPVLNPPSTRSSFPSPRLSLPTDSLSPDGGSIELEFYLAPEPFSMPSLLGAPPYSGLGGVGDPYVPLMVLMCRVCLEDKPIKPLPCCKKAVCEECLKVYLSAQVQLGQVEIKCPITECFEFLEETTVVYNLTHEDSIKYKYFLELGRIDSSTKPCPQCKHFTTFKKKGHIPTPSRSESKYKIQCPTCQFVWCFKCHSPWHEGVNCKEYKKGDKLLRHWASEIEHGQRNAQKCPKCKIHIQRTEGCDHMTCSQCNTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFIAPLIMVLGLALGAIAVVIGLFVFPIYCLCKKQRKRSRTGMHW"},{"id":"SEQ_01747","a":"O00418","g":"EEF2K","d":"Eukaryotic elongation factor 2 kinase","L":725,"m":[{"c":"FHLE[DH]φ[AI]","u":7,"sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed occurrences of an invariant FHLE tetrapeptide core followed by [DH] and two hydrophobic positions across three structured regions of the protein.","i":[[102,108,"FHLEDIA"],[226,232,"FHLEHYI"],[553,559,"FHLEHAA"]]},{"c":"[YL]φxxAxEA","u":8,"sp":"dispersed","x":"structured_like","cf":"high","why":"Four non-overlapping helical motif repeats in the C-terminal structured region anchored by an N-terminal bulky hydrophobic/tyrosine dyad ([YL]φ) and an invariant AxEA C-terminal signature.","i":[[600,607,"YLLKAAEA"],[665,672,"YMMLAREA"],[692,699,"LYTQAAEA"],[712,719,"YYQKAEEA"]]}],"s":"MADEDLIFRLEGVDGGQSPRAGHDGDSDGDSDDEEGYFICPITDDPSSNQNVNSKVNKYYSNLTKSERYSSSGSPANSFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAVTGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRICESMGLAPFDLSPRERDAVNQNTKLLQSAKTILRGTEEKCGSPQVRTLSGSRPPLLRPLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFSDLDNMASRDHDHLDNHRESENSGDSGYPSEKRGELDDPEPREHGHSYSNRKYESDEDSLGSSGRVCVEKWNLLNSSRLHLPRASAVALEVQRLNALDLEKKIGKSILGKVHLAMVRYHEGGRFCEKGEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDYLLKAAEAGDRQSMILVARAFDSGQNLSPDRCQDWLEALHWYNTALEMTDCDEGGEYDGMQDEPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAWAQMEE"},{"id":"SEQ_01750","a":"A6QL64","g":"ANKRD36","d":"Ankyrin repeat domain-containing protein 36A","L":1915,"m":[{"c":"VS[SPC]xK[QPK][PS]xx[KTE]x[TIS]xxxx[DVG]Sφ[SLP]x[ITM][ATP][TR][EGI]x[KG]x[GE]xx[STC][GRK][TKR]","u":34,"sp":"tandem","x":"disordered_like","cf":"high","why":"Extensive 23-copy 34-aa repeat array in the central disordered-like region (2 head-to-tail copies at 267-334 and 21 contiguous head-to-tail copies at 545-1258) anchored by invariant V1, S2, K5, S18 and strongly conserved Sφ[SLP] and [ITM][ATP][TR] cores.","i":[[267,300,"VSSQKQPALKATSGKEDSISNIATEIKDGQKSGT"],[301,334,"VSSQKQPALKDTSDKDDSVSNTATEIKDEQKSGT"],[545,578,"VSSQKQPAEKATSDDKDSVSNIATEIKEGPISGT"],[579,612,"VSSQKQPAEKATSDEKDSVSNIATEIKKGQQSGT"],[613,646,"VSPQKQSAWKVIFKKKVSLLNIATRIMGGGKSGT"],[647,680,"VSSQKQPASKATSDKTDSALNIATEIKDGLQCGT"],[681,714,"VSSQKQPALKATTDEEDSVSNIATEIKDGEKSGT"],[715,748,"VSSQKQPALKATTDEEDSVSNIATEIKDGEKSGT"],[749,782,"VSSQKQPALKATTDEKDSVSNIATEIKDGEKSGT"],[783,816,"VSSQKPPALTATSDEEGSVLSIARENKDGEKSRT"],[817,850,"VSSRKKPALKATSDEKDSFSNITRGKKDGEISRK"],[851,884,"VSSQKPPTLKGTSDEEDSVLGIARENKDGEKSRT"],[885,918,"VSSEKPPGLKASSAEKDSVLNIARGKKDGEKTKR"],[919,952,"VSSRKKPSLEATSDEKDSFSNITREKKDGEISRK"],[953,986,"VSSQKPPALKGTSDEEDSVLGIARENKDGEKSRT"],[987,1020,"VSSEKPPGLKATSDEKDSVLNIARGKKDGEKTRT"],[1021,1054,"VSSQKPPTLKATSDEEDSVLSIARENKDGEKSRT"],[1055,1088,"VSSEKPSGLKATSAEKDSVLNIARGKKYGEKTKR"],[1089,1122,"VSSRKKPALKATSDEKDSVLYIAREKKDGEKSRT"],[1123,1156,"VSSPKQPALKAICDKEDSVPNMATEKKDEQISGT"],[1157,1190,"VSCQKQPALKATSDKKDSVSNIPTEIKDGQQSGT"],[1191,1224,"VSSQKQPAWKATSVKKDSVSNIATEIKDGQIRGT"],[1225,1258,"VSPQKQSAQKVIFKKKVSLLNIATRITGGWKSGT"]]},{"c":"xx[EDG][RY]o[AP]L[HIL]xA[CV]xx[GER]xxx[MCI]φxxLψ[SKQ]xxx[END]x[NEL]xx[DS]","u":33,"sp":"tandem","x":"structured_like","cf":"high","why":"Five contiguous head-to-tail 33-aa structured repeats in the N-terminal region (residues 63-227) defined by invariant L7, A10, L22 and conserved o[AP]L[HIL]xA[CV] and φxxLψ hydrophobic cores.","i":[[63,95,"RKERTALHLACATGQPEMVHLLVSRRCELNLCD"],[96,128,"REDRTPLIKAVQLRQEACATLLLQNGANPNITD"],[129,161,"FFGRTALHYAVYNEDTSMIEKLLSHGTNIEECS"],[162,194,"KCEYQPLLFAVSRRKVKMVEFLLKKKANVNAID"],[195,227,"YLGRSALIHAVTLGEKDIVILLLQHNIDVLSRD"]]},{"c":"VLP[AP]VE[QE]xψ[ND]RxLYx[PL]DxφAQPVTx[ND]xF[SA]LESExISxxYφxxR+xISxxSφxx","u":53,"sp":"tandem","x":"mixed","cf":"high","why":"Head-to-tail 53-aa internal duplication (residues 335-440) sharing 47% sequence identity (25/53 identical positions including VLP, R.LY, AQPVT, F.LESE.IS, and R+.IS).","i":[[335,387,"VLPAVEQCLNRSLYRPDAVAQPVTENEFSLESEIISKLYIPKRKIISPRSIKD"],[388,440,"VLPPVEEAVDRCLYLLDRFAQPVTKDKFALESENISEPYFTNRRTISQQSAEN"]]}],"s":"MEDGKRERWPTLMERLCSDGFAFPQYPIKPYHLKRIHRAVLHGNLEKLKYLLLTYYDANKRDRKERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQLRQEACATLLLQNGANPNITDFFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKCEYQPLLFAVSRRKVKMVEFLLKKKANVNAIDYLGRSALIHAVTLGEKDIVILLLQHNIDVLSRDAFRKIAGDYAIEAKNRVIFDLIYEYERKRYEDLPINSNPVSSQKQPALKATSGKEDSISNIATEIKDGQKSGTVSSQKQPALKDTSDKDDSVSNTATEIKDEQKSGTVLPAVEQCLNRSLYRPDAVAQPVTENEFSLESEIISKLYIPKRKIISPRSIKDVLPPVEEAVDRCLYLLDRFAQPVTKDKFALESENISEPYFTNRRTISQQSAENLDAACGIDKTENGNMFEDQNVDKEGKALPATGQKANVSPEQPPLFTHTVKDRDHISTRFLGGMDSLTSSEESSERPPLSTLTLKEADPSSKAAMRRKDSPPPGKVSSQKQPAEKATSDDKDSVSNIATEIKEGPISGTVSSQKQPAEKATSDEKDSVSNIATEIKKGQQSGTVSPQKQSAWKVIFKKKVSLLNIATRIMGGGKSGTVSSQKQPASKATSDKTDSALNIATEIKDGLQCGTVSSQKQPALKATTDEEDSVSNIATEIKDGEKSGTVSSQKQPALKATTDEEDSVSNIATEIKDGEKSGTVSSQKQPALKATTDEKDSVSNIATEIKDGEKSGTVSSQKPPALTATSDEEGSVLSIARENKDGEKSRTVSSRKKPALKATSDEKDSFSNITRGKKDGEISRKVSSQKPPTLKGTSDEEDSVLGIARENKDGEKSRTVSSEKPPGLKASSAEKDSVLNIARGKKDGEKTKRVSSRKKPSLEATSDEKDSFSNITREKKDGEISRKVSSQKPPALKGTSDEEDSVLGIARENKDGEKSRTVSSEKPPGLKATSDEKDSVLNIARGKKDGEKTRTVSSQKPPTLKATSDEEDSVLSIARENKDGEKSRTVSSEKPSGLKATSAEKDSVLNIARGKKYGEKTKRVSSRKKPALKATSDEKDSVLYIAREKKDGEKSRTVSSPKQPALKAICDKEDSVPNMATEKKDEQISGTVSCQKQPALKATSDKKDSVSNIPTEIKDGQQSGTVSSQKQPAWKATSVKKDSVSNIATEIKDGQIRGTVSPQKQSAQKVIFKKKVSLLNIATRITGGWKSGTEYPENLPTLKATIENKNSVLNTATKMKDVQTSTPAEQDLEMASEGEQKRLEEYENNQPQVKNQIHSRDDLDDIIQSSQTVSEDGDSLCCNCKNVILLIDQHEMKCKDCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEEVHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQNLEKKYLKDFEIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAEREVAVRQLQQKRDDVLNKGSATKALLDASSRHCTYLENGMQDSRKKLDQMRSQFQEIQDQLTATIRCTKEMEGDTQKLEVEHVMMRKIIKKQDDQIERLEKILQHSSLMLQVFES"},{"id":"SEQ_01778","a":"P08572","g":"COL4A2","d":"Collagen alpha-2(IV) chain","L":1712,"m":[{"c":"HSQxxoxPxCPφGφxxLWxGYSφLφx(x){14,15}GSCLxxFxxxPFψxCN(x){4,5}C(x){8,9}ΩWL[ST]T(x){17,23}ISRC[SQ]VC[EM]","u":"100-107","sp":"tandem","x":"structured_like","cf":"high","why":"C-terminal globular region immediately following the long collagenous G-x-y domain contains a strongly conserved 2-copy tandem domain duplication (separated by an 8-aa linker) sharing six invariant cysteines and conserved sequence blocks including HSQ, CPφGφxxLWxGYSφLφ, GSCLxxFxxxPFψxCN, ΩWL[ST]T, and ISRC[SQ]VC[EM].","i":[[1495,1594,"HSQTDQEPMCPVGMNKLWSGYSLLYFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTAPLPMMPVAEDEIKPYISRCSVCE"],[1603,1709,"HSQDVSIPHCPAGWRSLWIGYSFLMHTAAGDEGGGQSLVSPGSCLEDFRATPFIECNGGRGTCHYYANKYSFWLTTIPEQSFQGSPSADTLKAGLIRTHISRCQVCM"]]}],"s":"MGRDQRAVAGPALRRWLLLGTVTVGFLAQSVLAGVKKFDVPCGGRDCSGGCQCYPEKGGRGQPGPVGPQGYNGPPGLQGFPGLQGRKGDKGERGAPGVTGPKGDVGARGVSGFPGADGIPGHPGQGGPRGRPGYDGCNGTQGDSGPQGPPGSEGFTGPPGPQGPKGQKGEPYALPKEERDRYRGEPGEPGLVGFQGPPGRPGHVGQMGPVGAPGRPGPPGPPGPKGQQGNRGLGFYGVKGEKGDVGQPGPNGIPSDTLHPIIAPTGVTFHPDQYKGEKGSEGEPGIRGISLKGEEGIMGFPGLRGYPGLSGEKGSPGQKGSRGLDGYQGPDGPRGPKGEAGDPGPPGLPAYSPHPSLAKGARGDPGFPGAQGEPGSQGEPGDPGLPGPPGLSIGDGDQRRGLPGEMGPKGFIGDPGIPALYGGPPGPDGKRGPPGPPGLPGPPGPDGFLFGLKGAKGRAGFPGLPGSPGARGPKGWKGDAGECRCTEGDEAIKGLPGLPGPKGFAGINGEPGRKGDRGDPGQHGLPGFPGLKGVPGNIGAPGPKGAKGDSRTITTKGERGQPGVPGVPGMKGDDGSPGRDGLDGFPGLPGPPGDGIKGPPGDPGYPGIPGTKGTPGEMGPPGLGLPGLKGQRGFPGDAGLPGPPGFLGPPGPAGTPGQIDCDTDVKRAVGGDRQEAIQPGCIGGPKGLPGLPGPPGPTGAKGLRGIPGFAGADGGPGPRGLPGDAGREGFPGPPGFIGPRGSKGAVGLPGPDGSPGPIGLPGPDGPPGERGLPGEVLGAQPGPRGDAGVPGQPGLKGLPGDRGPPGFRGSQGMPGMPGLKGQPGLPGPSGQPGLYGPPGLHGFPGAPGQEGPLGLPGIPGREGLPGDRGDPGDTGAPGPVGMKGLSGDRGDAGFTGEQGHPGSPGFKGIDGMPGTPGLKGDRGSPGMDGFQGMPGLKGRPGFPGSKGEAGFFGIPGLKGLAGEPGFKGSRGDPGPPGPPPVILPGMKDIKGEKGDEGPMGLKGYLGAKGIQGMPGIPGLSGIPGLPGRPGHIKGVKGDIGVPGIPGLPGFPGVAGPPGITGFPGFIGSRGDKGAPGRAGLYGEIGATGDFGDIGDTINLPGRPGLKGERGTTGIPGLKGFFGEKGTEGDIGFPGITGVTGVQGPPGLKGQTGFPGLTGPPGSQGELGRIGLPGGKGDDGWPGAPGLPGFPGLRGIRGLHGLPGTKGFPGSPGSDIHGDPGFPGPPGERGDPGEANTLPGPVGVPGQKGDQGAPGERGPPGSPGLQGFPGITPPSNISGAPGDKGAPGIFGLKGYRGPPGPPGSAALPGSKGDTGNPGAPGTPGTKGWAGDSGPQGRPGVFGLPGEKGPRGEQGFMGNTGPTGAVGDRGPKGPKGDPGFPGAPGTVGAPGIAGIPQKIAVQPGTVGPQGRRGPPGAPGEMGPQGPPGEPGFRGAPGKAGPQGRGGVSAVPGFRGDEGPIGHQGPIGQEGAPGRPGSPGLPGMPGRSVSIGYLLVKHSQTDQEPMCPVGMNKLWSGYSLLYFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTAPLPMMPVAEDEIKPYISRCSVCEAPAIAIAVHSQDVSIPHCPAGWRSLWIGYSFLMHTAAGDEGGGQSLVSPGSCLEDFRATPFIECNGGRGTCHYYANKYSFWLTTIPEQSFQGSPSADTLKAGLIRTHISRCQVCMKNL"},{"id":"SEQ_01783","a":"P24394","g":"IL4R","d":"Interleukin-4 receptor subunit alpha","L":825,"m":[{"c":"[GP]xx[GA]Y[KRQ]xFxxxψ","u":12,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed 12-aa tyrosine-based motifs within the C-terminal P/S/E-rich disordered tail (with the last three copies arrayed at an exact 28-residue period) anchored by invariant Y and F in a [GA]Y[KRQ]xF core, an N-terminal [GP] anchor, and a C-terminal aliphatic ψ residue.","i":[[493,504,"GNPAYRSFSNSL"],[571,582,"PTSGYQEFVHAV"],[599,610,"GEAGYKAFSSLL"],[627,638,"GEEGYKPFQDLI"]]}],"s":"MGWLCSGLLFPVSCLVLLQVASSGNMKVLQEPTCVSDYMSISTCEWKMNGPTNCSTELRLLYQLVFLLSEAHTCIPENNGGAGCVCHLLMDDVVSADNYTLDLWAGQQLLWKGSFKPSEHVKPRAPGNLTVHTNVSDTLLLTWSNPYPPDNYLYNHLTYAVNIWSENDPADFRIYNVTYLEPSLRIAASTLKSGISYRARVRAWAQCYNTTWSEWSPSTKWHNSYREPFEQHLLLGVSVSCIVILAVCLLCYVSITKIKKEWWDQIPNPARSRLVAIIIQDAQGSQWEKRSRGQEPAKCPHWKNCLTKLLPCFLEHNMKRDEDPHKAAKEMPFQGSGKSAWCPVEISKTVLWPESISVVRCVELFEAPVECEEEEEVEEEKGSFCASPESSRDDFQEGREGIVARLTESLFLDLLGEENGGFCQQDMGESCLLPPSGSTSAHMPWDEFPSAGPKEAPPWGKEQPLHLEPSPPASPTQSPDNLTCTETPLVIAGNPAYRSFSNSLSQSPCPRELGPDPLLARHLEEVEPEMPCVPQLSEPTTVPQPEPETWEQILRRNVLQHGAAAAPVSAPTSGYQEFVHAVEQGGTQASAVVGLGPPGEAGYKAFSSLLASSAVSPEKCGFGASSGEEGYKPFQDLIPGCPGDPAPVPVPLFTFGLDREPPRSPQSSHLPSSSPEHLGLEPGEKVEDMPKPPLPQEQATDPLVDSLGSGIVYSALTCHLCGHLKQCHGQEDGGQTPVMASPCCGCCCGDRSSPPTTPLRAPDPSPGGVPLEASLCPASLAPSGISEKSKSSSSFHPAPGNAQSSSQTPKIVNFVSVGPTYMRVS"},{"id":"SEQ_01785","a":"Q92841","g":"DDX17","d":"Probable ATP-dependent RNA helicase DDX17","L":729,"m":[{"c":"Y[GT][AQT]xx","u":5,"sp":"tandem","x":"disordered_like","cf":"high","why":"Six head-to-tail tandem pentapeptide repeats in the C-terminal G/S/Q/Y-rich disordered tail anchored by an invariant Tyr at position 1, Gly/Thr (5/6 Gly) at position 2, and Ala/Gln/Thr (4/6 Ala) at position 3.","i":[[635,639,"YGQGT"],[640,644,"YGAAA"],[645,649,"YGTSS"],[650,654,"YTAQE"],[655,659,"YGAGT"],[660,664,"YGASS"]]}],"s":"MPTGFVAPILCVLLPSPTREAATVASATGDSASERESAAPAAAPTAEAPPPSVVTRPEPQALPSPAIRAPLPDLYPFGTMRGGGFGDRDRDRDRGGFGARGGGGLPPKKFGNPGERLRKKKWDLSELPKFEKNFYVEHPEVARLTPYEVDELRRKKEITVRGGDVCPKPVFAFHHANFPQYVMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGDGPICLVLAPTRELAQQVQQVADDYGKCSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLESGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYTQINVGNLELSANHNILQIVDVCMESEKDHKLIQLMEEIMAEKENKTIIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTFFTPGNLKQARELIKVLEEANQAINPKLMQLVDHRGGGGGGGGRSRYRTTSSANNPNLMYQDECDRRLRGVKDGGRRDSASYRDRSETDRAGYANGSGYGSPNSAFGAQAGQYTYGQGTYGAAAYGTSSYTAQEYGAGTYGASSTTSTGRSSQSSSQQFSGIGRSGQQPQPLMSQQFAQPPGATNMIGYMGQTAYQYPPPPPPPPPSRK"},{"id":"SEQ_01796","a":"P39059","g":"COL15A1","d":"Collagen alpha-1(XV) chain","L":1388,"m":[{"c":"[GD][PI]xxE[EDK]xL[AT][AT][AT][AT][AT][GAE](x){7,10}[EDG][EAV]E[AS][SG][GS][VP][PA][PT][GD][GE][PL]x[LP][SLP][MLT][SAP][TA]x[ASN][PL][EG][ER]xφT[PVS]","u":"48-51","sp":"tandem","x":"disordered_like","cf":"high","why":"Four head-to-tail 48-51 aa tandem repeats in the acidic/Ala/Pro/Ser/Thr-rich disordered region preceding the collagenous domain, anchored by invariant E, L, E, and T positions alongside conserved L[AT]5 tracts, E[AS][SG][GS][VP][PA][PT] cores, and C-terminal φT[PVS] motifs.","i":[[350,400,"DIAEEKNLAATAAGLAEVPISTAGEAEASSVPTGGPTLSMSTENPEEGVTP"],[401,451,"GPDNEERLAATAAGEAEALASMPGEVEASGVAPGELDLSMSAQSLGEEATV"],[452,501,"GPSSEDSLTTAAAATEVSLSTFEDEEASGVPTDGLAPLTATMAPERAVTS"],[502,549,"GPGDEEDLAAATTEEPLITAGGEESGSPPPDGPPLPLPTVAPERWITP"]]}],"s":"MAPRRNNGQCWCLLMLLSVSTPLPAVTQTRGATETASQGHLDLTQLIGVPLPSSVSFVTGYGGFPAYSFGPGANVGRPARTLIPSTFFRDFAISVVVKPSSTRGGVLFAITDAFQKVIYLGLRLSGVEDGHQRIILYYTEPGSHVSQEAAAFSVPVMTHRWNRFAMIVQGEEVTLLVNCEEHSRIPFQRSSQALAFESSAGIFMGNAGATGLERFTGSLQQLTVHPDPRTPEELCDPEESSASGETSGLQEADGVAEILEAVTYTQASPKEAKVEPINTPPTPSSPFEDMELSGEPVPEGTLETTNMSIIQHSSPKQGSGEILNDTLEGVHSVDGDPITDSGSGAGAFLDIAEEKNLAATAAGLAEVPISTAGEAEASSVPTGGPTLSMSTENPEEGVTPGPDNEERLAATAAGEAEALASMPGEVEASGVAPGELDLSMSAQSLGEEATVGPSSEDSLTTAAAATEVSLSTFEDEEASGVPTDGLAPLTATMAPERAVTSGPGDEEDLAAATTEEPLITAGGEESGSPPPDGPPLPLPTVAPERWITPAQREHVGMKGQAGPKGEKGDAGEELPGPPEPSGPVGPTAGAEAEGSGLGWGSDVGSGSGDLVGSEQLLRGPPGPPGPPGLPGIPGKPGTDVFMGPPGSPGEDGPAGEPGPPGPEGQPGVDGATGLPGMKGEKGARGPNGSVGEKGDPGNRGLPGPPGKKGQAGPPGVMGPPGPPGPPGPPGPGCTMGLGFEDTEGSGSTQLLNEPKLSRPTAAIGLKGEKGDRGPKGERGMDGASIVGPPGPRGPPGHIKVLSNSLINITHGFMNFSDIPELVGPPGPDGLPGLPGFPGPRGPKGDTGLPGFPGLKGEQGEKGEPGAILTEDIPLERLMGKKGEPGMHGAPGPMGPKGPPGHKGEFGLPGRPGRPGLNGLKGTKGDPGVIMQGPPGLPGPPGPPGPPGAVINIKGAIFPIPVRPHCKMPVDTAHPGSPELITFHGVKGEKGSWGLPGSKGEKGDQGAQGPPGPPLDLAYLRHFLNNLKGENGDKGFKGEKGEKGDINGSFLMSGPPGLPGNPGPAGQKGETVVGPQGPPGAPGLPGPPGFGRPGDPGPPGPPGPPGPPAILGAAVALPGPPGPPGQPGLPGSRNLVTAFSNMDDMLQKAHLVIEGTFIYLRDSTEFFIRVRDGWKKLQLGELIPIPADSPPPPALSSNPHQLLPPPNPISSANYEKPALHLAALNMPFSGDIRADFQCFKQARAAGLLSTYRAFLSSHLQDLSTIVRKAERYSLPIVNLKGQVLFNNWDSIFSGHGGQFNMHIPIYSFDGRDIMTDPSWPQKVIWHGSSPHGVRLVDNYCEAWRTADTAVTGLASPLSTGKILDQKAYSCANRLIVLCIENSFMTDARK"},{"id":"SEQ_01807","a":"Q86UZ6","g":"ZBTB46","d":"Zinc finger and BTB domain-containing protein 46","L":589,"m":[{"c":"ΩxCxφC[SG](x){10,11}RH(x){3,4}H","u":"23-25","sp":"periodic","x":"structured_like","cf":"high","why":"Three periodic 23-25 aa repeats separated by regular 5-residue linkers (TGERP and SKDKK), anchored by an N-terminal aromatic-x-C-x-hydrophobic-C motif and a C-terminal RH-(x)3-4-H pair.","i":[[418,440,"FKCPYCSFSAMHQCILKRHMRSH"],[446,468,"YPCEICGKKFTRREHMKRHTLVH"],[474,498,"YVCKVCSRVFMSAASVGIRHGSRRH"]]}],"s":"MNNRKEDMEITSHYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSEQATVTHLDIVTAQGFKAIIDFMYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALDISIKSDASDELAEFEIGASSSSSTEALISAVMAGRSISPWLARRTSPANSSGDSAIASCHDGGSSYGKEDQEPKADGPDDVSSQPLWPGDVGYGPLRIKEEQVSPSQYGGSELPSAKDGAVQNSFSEQSAGDAWQPTGRRKNRKNKETVRHITQQVEDDSRASSPVPSFLPTSGWPFSSRDSNADLSVTEASSSDSRGERAELYAQVEEGLLGGEASYLGPPLTPEKDDALHQATAVANLRAALMSKNSLLSLKADVLGDDGSLLFEYLPRGAHSLSLNEFTVIRKKFKCPYCSFSAMHQCILKRHMRSHTGERPYPCEICGKKFTRREHMKRHTLVHSKDKKYVCKVCSRVFMSAASVGIRHGSRRHGVCTDCAGRGMAGPLDHGGGGGEGSPEALFPGDGPYLEDPEDPRGEAEELGEDDEGLAPEDALLADDKDEEDSPRPRSPPGGPDKDFAWLS"},{"id":"SEQ_01809","a":"Q8IXQ4","g":"GPALPP1","d":"GPALPP motifs-containing protein 1","L":340,"m":[{"c":"φφGPALPP[GN][FY][KI]","u":11,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed 11-residue copies in the N-terminal disordered region sharing an invariant GPALPP core flanked by two N-terminal hydrophobic residues and a C-terminal [GN][FY][KI] triad.","i":[[5,15,"LIGPALPPGFK"],[30,40,"VAGPALPPNYK"],[90,100,"FFGPALPPGFK"],[110,120,"IIGPALPPGFI"]]}],"s":"MARDLIGPALPPGFKARGTAEDEERDPSPVAGPALPPNYKSSSSDSSDSDEDSSSLYEEGNQESEEDDSGPTARKQRKNQDDDDDDDDGFFGPALPPGFKKQDDSPPRPIIGPALPPGFIKSTQKSDKGRDDPGQQETDSSEDEDIIGPMPAKGPVNYNVTTEFEKRAQRMKEKLTKGDDDSSKPIVRESWMTELPPEMKDFGLGPRTFKRRADDTSGDRSIWTDTPADRERKAKETQEARKSSSKKDEEHILSGRDKRLAEQVSSYNESKRSESLMDIHHKKLKSKAAEDKNKPQERIPFDRDKDLKVNRFDEAQKKALIKKSRELNTRFSHGKGNMFL"},{"id":"SEQ_01821","a":"O00567","g":"NOP56","d":"Nucleolar protein 56","L":594,"m":[{"c":"[PS]K+K+[SK][FT][SP]KEExψ[SN](x){1,2}[LP]EE(x){1,2}G","u":"20-22","sp":"periodic","x":"disordered_like","cf":"high","why":"Three complete 20-22 aa repeats in the C-terminal disordered tail separated by 4-residue linkers (STSI and HRSG) and flanked by degenerate N/C-terminal polybasic copies, combining a conserved [PS]K+K+...KEE head with a ψ[SN](x)1-2[LP]EE(x)1-2G acidic tail.","i":[[506,527,"PKKKKSFSKEELMSSDLEETAG"],[532,551,"PKRKKSTPKEETVNDPEEAG"],[556,577,"SKKKRKFSKEEPVSSGPEEAVG"]]}],"s":"MVLLHVLFEHAVGYALLALKEVEEISLLQPQVEESVLNLGKFHSIVRLVAFCPFASSQVALENANAVSEGVVHEDLRLLLETHLPSKKKKVLLGVGDPKIGAAIQEELGYNCQTGGVIAEILRGVRLHFHNLVKGLTDLSACKAQLGLGHSYSRAKVKFNVNRVDNMIIQSISLLDQLDKDINTFSMRVREWYGYHFPELVKIINDNATYCRLAQFIGNRRELNEDKLEKLEELTMDGAKAKAILDASRSSMGMDISAIDLINIESFSSRVVSLSEYRQSLHTYLRSKMSQVAPSLSALIGEAVGARLIAHAGSLTNLAKYPASTVQILGAEKALFRALKTRGNTPKYGLIFHSTFIGRAAAKNKGRISRYLANKCSIASRIDCFSEVPTSVFGEKLREQVEERLSFYETGEIPRKNLDVMKEAMVQAEEAAAEITRKLEKQEKKRLKKEKKRLAALALASSENSSSTPEECEEMSEKPKKKKKQKPQEVPQENGMEDPSISFSKPKKKKSFSKEELMSSDLEETAGSTSIPKRKKSTPKEETVNDPEEAGHRSGSKKKRKFSKEEPVSSGPEEAVGKSSSKKKKKFHKASQED"},{"id":"SEQ_01828","a":"P01042","g":"KNG1","d":"Kininogen-1","L":644,"m":[{"c":"C(x){3,9}-LxxxψxxxψxxφN(x){5,7}oφφφ(x){8,10}[QT]V[VG][AS][GD]xxΩxφxΩxφx[EQ][GT][DNT]C(x){9,10}[DS]C(x){8,10}[GL][ED]C[TN][AD]x[VA][GY]xxxxx+xxxx[ST][QV][TN]C","u":"99-104","sp":"periodic","x":"structured_like","cf":"high","why":"Three structured ~100-aa repeat domains separated by regular 18-aa linkers, anchored by five invariant cysteines, an N-terminal -LxxxψxxxψxxφN helix, and a conserved [QT]V[VG][AS][GD]xxΩxφxΩxφx[EQ][GT][DNT]C beta-hairpin core.","i":[[28,126,"CNDKDLFKAVDAALKKYNSQNQSNNQFVLYRITEATKTVGSDTFYSFKYEIKEGDCPVQSGKTWQDCEYKDAAKAATGECTATVGKRSSTKFSVATQTC"],[145,248,"CVHPISTQSPDLEPILRHGIQYFNNNTQHSSLFMLNEVKRAQRQVVAGLNFRITYSIVQTNCSKENFLFLTPDCKSLWNGDTGECTDNAYIDIQLRIASFSQNC"],[267,370,"CPRDIPTNSPELEETLTHTITKLNAENNATFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKESNEELTESCETKKLGQSLDCNAEVYVVPWEKKIYPTVNC"]]},{"c":"[HR]x[LQ][GD]HGH[KQE]","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five 8-aa repeats in the C-terminal His/Gly-enriched disordered region (four separated by 2-aa linkers and a fifth after a 12-aa linker), anchored beyond simple H/G bias by [HR] at position 1, conserved Leu (4/5 copies) at position 3, fixed HGH, and polar/charged [KQE].","i":[[439,446,"HNLGHGHK"],[449,456,"RDQGHGHQ"],[459,466,"HGLGHGHE"],[469,476,"HGLGHGHK"],[489,496,"HVLDHGHK"]]}],"s":"MKLITILFLCSRLLLSLTQESQSEEIDCNDKDLFKAVDAALKKYNSQNQSNNQFVLYRITEATKTVGSDTFYSFKYEIKEGDCPVQSGKTWQDCEYKDAAKAATGECTATVGKRSSTKFSVATQTCQITPAEGPVVTAQYDCLGCVHPISTQSPDLEPILRHGIQYFNNNTQHSSLFMLNEVKRAQRQVVAGLNFRITYSIVQTNCSKENFLFLTPDCKSLWNGDTGECTDNAYIDIQLRIASFSQNCDIYPGKDFVQPPTKICVGCPRDIPTNSPELEETLTHTITKLNAENNATFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKESNEELTESCETKKLGQSLDCNAEVYVVPWEKKIYPTVNCQPLGMISLMKRPPGFSPFRSSRIGEIKEETTVSPPHTSMAPAQDEERDSGKEQGHTRRHDWGHEKQRKHNLGHGHKHERDQGHGHQRGHGLGHGHEQQHGLGHGHKFKLDDDLEHQGGHVLDHGHKHKHGHGHGKHKNKGKKNGKHNGWKTEHLASSSEDSTTPSAQTQEKTEGPTPIPSLAKPGVTVTFSDFQDSDLIATMMPPISPAPIQSDDDWIPDIQIDPNGLSFNPISDFPDTTSPKCPGRPWKSVSEINPTTQMKESYYFDLTDGLS"},{"id":"SEQ_01830","a":"Q96TA1","g":"NIBAN2","d":"Protein Niban 2","L":746,"m":[{"c":"[PE][EA]S[PS]PPA[SG]P","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 9-aa proline-rich motifs in the C-terminal disordered tail separated by 15-aa and 17-aa linkers, tightly constrained across all nine positions with five invariant anchors (S3, P5, P6, A7, P9) and two-state choices ([PE], [EA], [PS], [SG]).","i":[[639,647,"PESPPPASP"],[663,671,"PESPPPAGP"],[689,697,"EASSPPASP"]]}],"s":"MGDVLSTHLDDARRQHIAEKTGKILTEFLQFYEDQYGVALFNSMRHEIEGTGLPQAQLLWRKVPLDERIVFSGNLFQHQEDSKKWRNRFSLVPHNYGLVLYENKAAYERQVPPRAVINSAGYKILTSVDQYLELIGNSLPGTTAKSGSAPILKCPTQFPLILWHPYARHYYFCMMTEAEQDKWQAVLQDCIRHCNNGIPEDSKVEGPAFTDAIRMYRQSKELYGTWEMLCGNEVQILSNLVMEELGPELKAELGPRLKGKPQERQRQWIQISDAVYHMVYEQAKARFEEVLSKVQQVQPAMQAVIRTDMDQIITSKEHLASKIRAFILPKAEVCVRNHVQPYIPSILEALMVPTSQGFTEVRDVFFKEVTDMNLNVINEGGIDKLGEYMEKLSRLAYHPLKMQSCYEKMESLRLDGLQQRFDVSSTSVFKQRAQIHMREQMDNAVYTFETLLHQELGKGPTKEELCKSIQRVLERVLKKYDYDSSSVRKRFFREALLQISIPFLLKKLAPTCKSELPRFQELIFEDFARFILVENTYEEVVLQTVMKDILQAVKEAAVQRKHNLYRDSMVMHNSDPNLHLLAEGAPIDWGEEYSNSGGGGSPSPSTPESATLSEKRRRAKQVVSVVQDEEVGLPFEASPESPPPASPDGVTEIRGLLAQGLRPESPPPAGPLLNGAPAGESPQPKAAPEASSPPASPLQHLLPGKAVDLGPPKPSDQETGEQVSSPSSHPALHTTTEDSAGVQTEF"},{"id":"SEQ_01835","a":"Q4AC94","g":"C2CD3","d":"C2 domain-containing protein 3","L":2353,"m":[{"c":"xx[VQC][ERQ]Ω[HVY][FY]P[VN](x){5,6}ψx[KH](x){2,8}[LI][ITS]xxxφ[RVM]x[AKT][ST]","u":"30-36","sp":"dispersed","x":"structured_like","cf":"high","why":"Four globular beta-barrel-like repeats arranged as two paired modules (580-650 and 1028-1141), anchored by a conserved Ωx[FY]P[VN] aromatic-proline motif, a ψx[KH] strand motif, and a C-terminal [LI]xxxxφxxx[ST] hydrophobic strand separated by short variable loops.","i":[[579,608,"FFVEYHFPVGFSESGLGKTALITEVVRLAS"],[618,650,"FQQRFVFPVQFGGPMIEHWWNSNLTFQIYVKKT"],[1029,1064,"CYVQYYFPVQHSQSSVLKGPEFLENGITLKPFRTAT"],[1112,1142,"IWCRYYYPNVRDQKVAKGTLPLSRICAMVTT"]]},{"c":"LxφxφxH+GDxERVψxφA","u":18,"sp":"dispersed","x":"structured_like","cf":"medium","why":"Two non-overlapping globular segments in the C-terminal half sharing 8 exact identities (L, H, G, D, E, R, V, A) and 5 strict physicochemical matches (φ, φ, +, ψ, φ) in an ungapped 18-residue register.","i":[[1365,1382,"LSISFTHRGDRERVLEAA"],[1710,1727,"LVFKVWHKGDEERVIGFA"]]}],"s":"MKQRKGQGSGGSRGRKKRGLSDISPSTSLPPLVEGQLRCFLKLTVNRVIWKIAKPPTCVLVRVRWWGETSDGTLFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDGLPIGRVQINGLAQLSPTHQINGFFTIVSSTSKKLGELQVSLALEPLSETYDSYHPLPTTDMTENVLLSKQGFRENTEPSSTQFQVPSRPRDIHTIKIDGKELAANSSRSTTPRGKDHVCFAENPDTIKDSSFGLQHSLNSGQSLESVTLKGRAPRKQMSLLNSSEFQPQIRTVAKSHSDSCILSSNNLPTKDLLSALLEQGNKLRNAMVISAMKSSPETSMLLDQVHPPINEDSLRASTQIRAFSRNRFKDHIEDHLLPSTENTFWRHDTKADTRAIQLLLGSAELSQGNFWDGLGSPPDSPSPGSDVYCISELNDPQYDQSLLENLFYTAPKSDTSISDFLSEEDDIVPSKKISQSTALARSSKVLESSDHKLKKRSAGKRNRNLVEQQMLSETPEDAQTMTLSVDRLALLGRTHSVRIIIETMGVPPDSPQMTPGKKSYAGPPPKVTTAKKRTFFVEYHFPVGFSESGLGKTALITEVVRLASSKITDGKVKFQQRFVFPVQFGGPMIEHWWNSNLTFQIYVKKTPQKKPEVIGSVSLSLRAVIQSELLSFSDQLPVQQENGQSPFGPLKVTMELITDNKDFTGINTKLSGNTHYTPLCAPTSPNKALPELNQDMTCTKNPQNLNQIHEETAKKAQNLVLPNRKSPSPVAPHPSTFVATPASHNLVNQTNGTTKESALLLHVLLMVPDGKDFISGESEKQSPCNVYLNCKLFSTEEVTRSVIAWGTTQPVFNFSQVIPVSLSSKYLERLKNNVMVIETWNKVRSPGQDKLLGLVKLPLHQFYMSFKDAKISRLLLDAQYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSNQIMALQRLKNEEGTLPPFSPRPAHFLDQPTAASVAMAEDRGNGLMEHCFEIHIEMVKGLAPLQATVWGEADCYVQYYFPVQHSQSSVLKGPEFLENGITLKPFRTATTLCVPDPIFNSEHHHSLLLPAEVPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQKVAKGTLPLSRICAMVTTQHREDVGIQTFNLPLTPRIENRKELRNQSSGLLDVGLRYRRSPRTAEGVLAARTVSISVQIIRACGLQAAAKALAEREPALQFSATVGVNASVTTHLSFLPQGEQRRTHPVACSFCPEFSHHVEFTCNLVTQHCSGEACFLAELLEFAEVIFAVYHENTKSASDIISIESCKEYLLGVVKVPTKELLIKRSGITGWYPIILPEDGGLPHGLELMQKIVGGLELSISFTHRGDRERVLEAAEHLGWSFENSLKDFVRMDEGEPATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYKFYDHEAFWTPLKKPKESVNKKQIMVTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGNDSVERPHQTDSWIGSAYVDLARLGERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSLSSHLEPTHELDSMDCSSHSESEQLPRRNDEVQLSPPEVISCHQKSPASTQVPCSSTTAEVRLTQEGPADLDGTFAVSILVERAMHLSLKGSPLTERKVSIPSCCVSFATADESSPVYTQVVENTDSPIWNFQQQSRLSKELLLDPQQTLVFKVWHKGDEERVIGFASVDLSPLLSGFQFVCGWYNITDFSGECQGQIKVAVSPLESLIHFKEERQARRGVETSKSLIPIYSPFSFPASDTYAAFSSHMARQTLDQLAHASSKELDFSSPGRSDTTRSQASRHEEHVQNIRRFHESLHLQGEAPLPCDDKLTTSPLSSQTSILTSLRKNLSELDQIQRYFRQKLTKPFLPLSPQTQTAISQHQESCRDHLGPGASSLDPGSQCILEKSSNLVLQVSSLITDLQTITRDSQAALSSHRARSRSNKATTLPDAQDTEALQERCTMPDEPLVRAPDKGTDSPSPPPLEETSNGGRMLHESLRHAVPITRMQSSEDTEAGPAYSDEDYEEDIIEPRTLNEITTVTDKTSPWSSVISDTSEVISPQPDEVQREGPSCPSPGPFCREELMVKSSFLSSPERAVNPHLPRQGSPSQSLVACECEASKARVGGESASANPQPIPCPTLSGAQQSSTFVGWSSPQTDQNKEPKSEAPAENEAATSELGDSADSFKKLPLNLASQSRRENHKGPPIDSSDIRQRQVTTGSETSTKQSLLLPGPIVVPNFFLPPQQLEASLRMLSLSATLPPAATTDQDKSEATRGALSQRPCRPRPNSLPLNLPEEETLRIARIFSSQYSQKD"},{"id":"SEQ_01858","a":"A0JLT2","g":"MED19","d":"Mediator of RNA polymerase II transcription subunit 19","L":244,"m":[{"c":"[LM]x[DE]LPG","u":6,"sp":"dispersed","x":"mixed","cf":"medium","why":"Three non-overlapping 6-residue copies (one N-terminal copy separated by 35 residues from a head-to-tail tandem pair) share a fixed LPG C-terminal anchor preceded by an acidic [DE] residue and a conserved [LM] aliphatic residue at position 1.","i":[[68,73,"MRELPG"],[109,114,"LPDLPG"],[115,120,"MIDLPG"]]}],"s":"MENFTALFGAQADPPPPPTALGFGPGKPPPPPPPPAGGGPGTAPPPTAATAPPGADKSGAGCGPFYLMRELPGSTELTGSTNLITHYNLEQAYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILSSSFNPITGTMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDSDHKKKKKKKEEDPDRKRKKKEKKKKKNRHSPDHPGMGSSQASSSSSLR"},{"id":"SEQ_01861","a":"O14529","g":"CUX2","d":"Homeobox protein cut-like 2","L":1486,"m":[{"c":"[EQ]ψDTφ[ES]ψ[AT]x[QR]VKExLx[KD][HN][NG]ψ[GC]QRψFG[HE]xψLGL[ST]QGSVS-ψL[AS]RPKPW[RSH]KL[ST]xKG+EPFψ+M[KQ][QL]ΩL[SN]D","u":67,"sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed 67-aa globular domain repeats anchored by invariant DT, VKE, L, QRψFG, LGL[ST]QGSVS-ψL[AS]RPKPW, KG+EPFψ+M, and ΩL[SN]D motifs separated by variable disordered linkers.","i":[[552,618,"QLDTAEIAFQVKEQLLKHNIGQRVFGHYVLGLSQGSVSEILARPKPWRKLTVKGKEPFIKMKQFLSD"],[895,961,"EVDTLELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLSD"],[1046,1112,"ELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLND"]]},{"c":"S-DAIKSILEQA++Eψ[EQ][AS]Q","u":19,"sp":"dispersed","x":"mixed","cf":"high","why":"Two highly conserved 19-aa repeats (13/19 identical including an invariant 10-residue DAIKSILEQA core plus four conservative substitutions) separated by a 23-aa Pro/Thr/Gly-rich linker.","i":[[647,665,"SDDAIKSILEQAKKEIESQ"],[689,707,"SEDAIKSILEQARREMQAQ"]]}],"s":"MAANVGSMFQYWKRFDLRRLQKELNSVASELSARQEESEHSHKHLIELRREFKKNVPEEIREMVAPVLKSFQAEVVALSKRSQEAEAAFLSVYKQLIEAPDPVPVFEAARSLDDRLQPPSFDPSGQPRRDLHTSWKRNPELLSPKEQREGTSPAGPTLTEGSRLPGIPGKALLTETLLQRNEAEKQKGLQEVQITLAARLGEAEEKIKVLHSALKATQAELLELRRKYDEEAASKADEVGLIMTNLEKANQRAEAAQREVESLREQLASVNSSIRLACCSPQGPSGDKVNFTLCSGPRLEAALASKDREILRLLKDVQHLQSSLQELEEASANQIADLERQLTAKSEAIEKLEEKLQAQSDYEEIKTELSILKAMKLASSTCSLPQGMAKPEDSLLIAKEAFFPTQKFLLEKPSLLASPEEDPSEDDSIKDSLGTEQSYPSPQQLPPPPGPEDPLSPSPGQPLLGPSLGPDGTRTFSLSPFPSLASGERLMMPPAAFKGEAGGLLVFPPAFYGAKPPTAPATPAPGPEPLGGPEPADGGGGGAAGPGAEEEQLDTAEIAFQVKEQLLKHNIGQRVFGHYVLGLSQGSVSEILARPKPWRKLTVKGKEPFIKMKQFLSDEQNVLALRTIQVRQRGSITPRIRTPETGSDDAIKSILEQAKKEIESQKGGEPKTSVAPLSIANGTTPASTSEDAIKSILEQARREMQAQQQALLEMEVAPRGRSVPPSPPERPSLATASQNGAPALVKQEEGSGGPAQAPLPVLSPAAFVQSIIRKVKSEIGDAGYFDHHWASDRGLLSRPYASVSPSLSSSSSSGYSGQPNGRAWPRGDEAPVPPEDEAAAGAEDEPPRTGELKAEGATAEAGARLPYYPAYVPRTLKPTVPPLTPEQYELYMYREVDTLELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLSDQLGQAVGQQPGASQASPTEPRSSPSPPPSPTEPEKSSQEPLSLSLESSKENQQPEGRSSSSLSGKMYSGSQAPGGIQEIVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLNDPHNVEKLRDMKKLEKKAYLKRRYGLISTGSDSESPATRSECPSPCLQPQDLSLLQIKKPRVVLAPEEKEALRKAYQLEPYPSQQTIELLSFQLNLKTNTVINWFHNYRSRMRREMLVEGTQDEPDLDPSGGPGILPPGHSHPDPTPQSPDSETEDQKPTVKELELQEGPEENSTPLTTQDKAQVRIKQEQMEEDAEEEAGSQPQDSGELDKGQGPPKEEHPDPPGNDGLPKVAPGPLLPGGSTPDCPSLHPQQESEAGERLHPDPLSFKSASESSRCSLEVSLNSPSAASSPGLMMSVSPVPSSSAPISPSPPGAPPAKVPSASPTADMAGALHPSAKVNPNLQRRHEKMANLNNIIYRVERAANREEALEWEF"},{"id":"SEQ_01867","a":"O95208","g":"EPN2","d":"Epsin-2","L":641,"m":[{"c":"[DEN][PA]W[GPA]x","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Seven dispersed pentapeptide motifs anchored by an invariant W preceded by [DEN][PA] (predominantly DPW) and followed by [GPA]x, with one N-terminal loop copy and six closely spaced copies clustered across a central Pro/Ser/Thr/Ala-rich disordered region.","i":[[31,35,"DPWGP"],[352,356,"EPWGP"],[364,368,"NPWGG"],[377,381,"DPWPS"],[391,395,"DPWGV"],[409,413,"DPWAA"],[427,431,"DAWGA"]]},{"c":"[STP]x[ND]PFx","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four non-overlapping hexapeptide motifs in the C-terminal Pro/Ser/Thr/Gln-rich disordered tail anchored by an invariant PF core preceded by [ND] (predominantly NPF) and an N-terminal [STP] residue.","i":[[486,491,"SPDPFE"],[535,540,"SLNPFL"],[550,555,"PVNPFQ"],[635,640,"TTNPFL"]]}],"s":"MTTSSIRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMVWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVALLKDEERLKAERAQALKTKERMAQVATGMGSNQITFGRGSSQPNLSTSHSEQEYGKAGGSPASYHGSPEASLCPQHRTGAPLGQSEELQPLSQRHPFLPHLGLASRPNGDWSQPCLTCDRAARATSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQEERLRRGDDLRLQMALEESRRDTVKIPKKKEHGSLPQQTTLLDLMDALPSSGPAAQKAEPWGPSASTNQTNPWGGPAAPASTSDPWPSFGTKPAASIDPWGVPTGATVQSVPKNSDPWAASQQPASSAGKRASDAWGAVSTTKPVSVSGSFELFSNLNGTIKDDFSEFDNLRTSKKTAESVTSLPSQNNGTTSPDPFESQPLTVASSKPSSARKTPESFLGPNAALVNLDSLVTRPAPPAQSLNPFLAPGAPATSAPVNPFQVNQPQPLTLNQLRGSPVLGTSTSFGPGPGVESMAVASMTSAAPQPALGATGSSLTPLGPAMMNMVGSVGIPPSAAQATGTTNPFLL"},{"id":"SEQ_01871","a":"Q9HC56","g":"PCDH9","d":"Protocadherin-9","L":1237,"m":[{"c":"(x){23,29}φx[DA]x[DT]xxx[NA](x){26,35}φ-x[EK](x){24,34}ψxφx[DY]xND[NT]x[PG]xφ","u":"103-114","sp":"tandem","x":"structured_like","cf":"high","why":"Seven head-to-tail tandem 103-114 aa structured repeats across the N-terminal region defined by three conserved internal signature blocks: φx[DA]x[DT]xxx[NA] (typically ATDxDxGxN), a central φ-x[EK] (typically LDRE/FDRE) motif, and a C-terminal ψxφx[DY]xND[NT]x[PG]xφ (typically VxVxDVNDNxPxF) motif.","i":[[29,142,"TIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMF"],[143,252,"PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVF"],[253,358,"KEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNI"],[359,469,"DLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF"],[470,572,"NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKF"],[573,675,"THNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVV"],[676,781,"ISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNA"]]}],"s":"MDLRDFYLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQNEDYLTIMIAIIAGAMVVIVVIFVTVLVRCRHASRFKAAQRSKQGAEWMSPNQENKQNKKKKRKKRKSPKSSLLNFVTIEESKPDDAVHEPINGTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSVKKHHVIQELPLDNTFVGGCDTLSKRSSTSSDHFSASECSSQGGFKTKGPLHTRQCNSHSKSDNIPVTPQKCPSSTGFHIQENEESHYESQRRVTFHLPDGSQESCSDSGLGDHEPVGSGTLISHPLPLVQPQDEFYDQASPDKRTEADGNSDPNSDGPLGPRGLAEATEMCTQECLVLGHSDNCWMPPGLGPYQHPKSPLSTFAPQKEWVKKDKLVNGHTLTRAWKEDSNRNQFNDRKQYGSNEGHFNNGSHMTDIPLANLKSYKQAGGATESPKEHQL"},{"id":"SEQ_01881","a":"Q13112","g":"CHAF1B","d":"Chromatin assembly factor 1 subunit B","L":559,"m":[{"c":"Hxxxxxxxxxx(x){4,9}xψAxx[GS]xDxxxxφφxφ","u":"31-36","sp":"dispersed","x":"structured_like","cf":"high","why":"Five well-conserved 31-36 aa structured repeats anchored by an N-terminal fixed H, a 4-9 residue loop (4 aa in four copies, 9 aa in the first copy), an invariant A and D flanking a [GS] position in the central ψAxx[GS]xD motif, and a C-terminal hydrophobic φφxφ cluster.","i":[[11,46,"HNKEPVYSLDFQHGTAGRIHRLASAGVDTNVRIWKV"],[65,95,"HTKAVNVVRFSPTGEILASGGDDAVILLWKV"],[128,158,"HLEDVYDICWATDGNLMASASVDNTAIIWDV"],[170,200,"HKSYVQGVTWDPLGQYVATLSCDRVLRVYSI"],[345,375,"HYHTLSDISWSSDGAFLAISSTDGYCSFVTF"]]}],"s":"MKVITCEIAWHNKEPVYSLDFQHGTAGRIHRLASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQKKRVAFNVSKMLSGIGAEGEARSYRMFHDDSMKSFFRRLSFTPDGSLLLTPAGCVESGENVMNTTYVFSRKNLKRPIAHLPCPGKATLAVRCCPVYFELRPVVETGVELMSLPYRLVFAVASEDSVLLYDTQQSFPFGYVSNIHYHTLSDISWSSDGAFLAISSTDGYCSFVTFEKDELGIPLKEKPVLNMRTPDTAKKTKSQTHRGSSPGPRPVEGTPASRTQDPSSPGTTPPQARQAPAPTVIRDPPSITPAVKSPLPGPSEEKTLQPSSQNTKAHPSRRVTLNTLQAWSKTTPRRINLTPLKTDTPPSSVPTSVISTPSTEEIQSETPGDAQGSPPELKRPRLDENKGGTESLDP"},{"id":"SEQ_01889","a":"Q8N7U7","g":"TPRX1","d":"Tetra-peptide repeat homeobox protein 1","L":411,"m":[{"c":"[GA]P[IN]PG[PL]I[SP]","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Twelve highly conserved octapeptide repeats in the central proline/glycine-rich region with invariant P2, P4, G5, and I7 anchors and strictly binary choices at the remaining four positions, arranged in head-to-tail tandem runs and short 2-10 aa GPxx-linked clusters.","i":[[133,140,"APIPGPIS"],[151,158,"GPIPGPIS"],[161,168,"APIPGPIS"],[173,180,"GPNPGPIP"],[185,192,"GPIPGPIS"],[193,200,"GPIPGPIS"],[205,212,"GPIPGPIS"],[217,224,"GPNPGPIP"],[225,232,"GPIPGPIS"],[237,244,"GPIPGPIS"],[245,252,"GPNPGLIP"],[253,260,"GPIPGPIS"]]},{"c":"[GA]PIP[GS]PAQIP","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three non-overlapping decapeptide copies flanking both the N- and C-terminal boundaries of the central octapeptide repeat array, sharing 8 of 10 identical positions (PIP-PAQIP) and conservative [GA]/[GS] substitutions.","i":[[101,110,"APIPGPAQIP"],[119,128,"GPIPGPAQIP"],[267,276,"GPIPSPAQIP"]]}],"s":"MLSLREQQLQVWFKNRRAKLARERRLQQQPQRVPGQRGRGARAAPLVPAASASAPQRGPSGILPAAEPTICSLHQAWGGPGCRAQKGIPAALSPGPGPIPAPIPGPAQIPGPLPGSIPGPIPGPAQIPSPIPAPIPGPISGPVQIPGPFRGPIPGPISGPAPIPGPISGPFSGPNPGPIPGPNPGPIPGPISGPIPGPISVPIPGPIPGPISGPISGPNPGPIPGPIPGPISGPNPGPIPGPISGPNPGLIPGPIPGPISGPGPIIGPIPSPAQIPGPGRLQGPGPILSPGRMRSPGSLPGLAPILGPGSGPGSGSVPAPIPGPGSLPAPAPLWPQSPDASDFLPDTQLFPHFTELLLPLDPLEGSSVSTMTSQYQEGDDSMGKKHSGSQPQEEGGSVNENHSGPRLLLDL"},{"id":"SEQ_01894","a":"Q9BYN7","g":"ZNF341","d":"Zinc finger protein 341","L":854,"m":[{"c":"xxC(x){2,7}Cxxx[FY]xxxxxφxxH(x){1,5}[HC]","u":"21-28","sp":"dispersed","x":"structured_like","cf":"high","why":"Thirteen structured cysteine/histidine-anchored repeats featuring an invariant C-x(2,7)-C pair, a strictly conserved 12-residue core with aromatic [FY] and hydrophobic φ anchors, and a C-terminal H-x(1,5)-[HC] motif distributed as one N-terminal copy, a central pair, and a ten-copy C-terminal array mostly separated by 5-aa linkers.","i":[[53,76,"FLCGKCKKQFNSLPAFMTHKREQC"],[322,344,"LKCSYCDKSFTKNFDLQQHIRSH"],[350,372,"FQCIACGRAFAQKSNVKKHMQTH"],[445,467,"YLCQFCPSKFSTYFQLKSHMTQH"],[473,497,"YKCVVKSCAQTFPKLDTFLEHIKSH"],[503,525,"YRCHLCGKDFPSLYDLGVHQYSH"],[540,564,"YKCVKCVNKYSTPEALEHHLQTATH"],[566,588,"FPCPHCQKVFPCERYLRRHLPTH"],[594,616,"FKCQVCKKFFRREHYLKLHAHIH"],[622,644,"YKCSVCESAFNRKDKLKRHMLIH"],[650,677,"YKCPFSTHTGCSKEFNRPDKLKAHILSH"],[683,705,"HKCALCSKSFSRRAHLAEHQRAH"],[711,731,"FRCAGCAKGFSRHKYLKDHRC"]]}],"s":"MAQAIFEALEGMDNQTVLAVQSLLDGQGAVPDPTGQSVNAPPAIQPLDDEDVFLCGKCKKQFNSLPAFMTHKREQCQGNAPALATVSLATNSIYPPSAAPTAVQQAPTPANRQISTYITVPPSPLIQTLVQGNILVSDDVLMSAMSAFTSLDQPMPQGPPPVQSSLNMHSVPSYLTQPPPPPPPPPPLPPPPPPQPPPPPPQSLGPPGRPNPGGNGVVEVYSAAAPLAGSGTVEIQALGMQPYPPLEVPNQCVEPPVYPTPTVYSPGKQGFKPKGPNPAAPMTSATGGTVATFDSPATLKTRRAKGARGLPEAAGKPKAQKLKCSYCDKSFTKNFDLQQHIRSHTGEKPFQCIACGRAFAQKSNVKKHMQTHKVWPPGHSGGTVSRNSVTVQVMALNPSRQEDEESTGLGQPLPGAPQPQALSTAGEEEGDKPESKQVVLIDSSYLCQFCPSKFSTYFQLKSHMTQHKNEQVYKCVVKSCAQTFPKLDTFLEHIKSHQEELSYRCHLCGKDFPSLYDLGVHQYSHSLLPQHSPKKDNAVYKCVKCVNKYSTPEALEHHLQTATHNFPCPHCQKVFPCERYLRRHLPTHGSGGRFKCQVCKKFFRREHYLKLHAHIHSGEKPYKCSVCESAFNRKDKLKRHMLIHEPFKKYKCPFSTHTGCSKEFNRPDKLKAHILSHSGMKLHKCALCSKSFSRRAHLAEHQRAHTGNYKFRCAGCAKGFSRHKYLKDHRCRLGPQKDKDLQTRRPPQRRAAPRSCGSGGRKVLTPLPDPLGLEELKDTGAGLVPEAVPGKPPFAEPDAVLSIVVGGAVGAETELVVPGHAEGLGSNLALAELQAGAEGPCAMLAVPVYIQASE"},{"id":"SEQ_01895","a":"Q86UR5","g":"RIMS1","d":"Regulating synaptic membrane exocytosis protein 1","L":1692,"m":[{"c":"QLxVxVψxAxxL(x){10,11}PYVKψYφLxxxxxxxK++T+xφ+KxL-PxΩoQoφVΩ(x){7,11}ψL[EQ]ψxVW(x){10,11}FψG(x){1,3}ILψE[EL][EL](x){8,9}WYKL","u":"107-110","sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved ~108-aa structured domain repeats (positions 758-867 and 1552-1658) separated by a long disordered region, sharing multi-block sequence architecture anchored by QLxVxVψxAxxL, PYVKψYφL, a basic/aromatic-rich K++T+xφ+KxL-PxΩoQoφVΩ core, VW, FψG, and C-terminal WYKL.","i":[[758,867,"QLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPHWYKL"],[1552,1658,"QLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKL"]]}],"s":"MSSAVGPRGPRPPTVPPPMQELPDLSHLTEEERNIIMAVMDRQKEEEEKEEAMLKCVVRDMAKPAACKTPRNAENQPHQPSPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICHKTKFADGCGHLCSYCRTKFCARCGGRVSLRSNNEDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQTSQDGTLSDTATGAGSEVPREKKARLQERSRSQTPLSTAAASSQDAAPPSAPPDRSKGAEPSQQALGPEQKQASSRSRSEPPRERKKTPGLSEQNGKGALKSERKRVPKTSAQPVEGAVEERERKERRESRRLEKGRSQDYPDTPEKRDEGKAADEEKQRKEEDYQTRYRSDPNLARYPVKPPPEEQQMRMHARVSRARHERRHSDVALPRTEAGAALPEGKAGKRAPAAARASPPDSPRAYSAERTAETRAPGAKQLTNHSPPAPRHGPVPAEAPELKAQEPLRKQSRLDPSSAVLMRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRSKRGGKKRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRTTMPKDSGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKMERPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHIHGESSSKKLQRSQRISDSDISDYEVDDGIGVVPPVGYRSSARESKSTTLTVPEQQRTTHHRSRSVSPHRGNDQGKPRSRLPNVPLQRSLDEIHPTRRSRSPTRHHDASRSPVDHRTRDVDSQYLSEQDSELLMLPRAKRGRSAECLHTTRHLVRHYKTLPPKMPLLQSSSHWNIYSSILPAHTKTKSVTRQDISLHHECFNSTVLRFTDEILVSELQPFLDRARSASTNCLRPDTSLHSPERERGRWSPSLDRRRPPSPRIQIQHASPENDRHSRKSERSSIQKQTRKGTASDAERVLPTCLSRRGHAAPRATDQPVIRGKHPARSRSSEHSSIRTLCSMHHLVPGGSAPPSPLLTRMHRQRSPTQSPPADTSFSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSSQELDREQYSKYNIHKDQYRSCDNVSAKSSDSDVSDVSAISRTSSASRLSSTSFMSEQSERPRGRISSFTPKMQGRRMGTSGRSIMKSTSVSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQSSLESSTGPPCIRS"},{"id":"SEQ_01909","a":"Q9UMS6","g":"SYNPO2","d":"Synaptopodin-2","L":1093,"m":[{"c":"[AL]Pxxo[GS]+G[AV][LQ][LM]F[AK]KR[QR]xR[AM]x[KQ][IY][TV]φ","u":24,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 24-residue repeats embedded within the disordered C-terminal half, anchored by six invariant positions (P, G, F, K, R, R) and strongly conserved hydrophobic and basic positions across the full ungapped alignment.","i":[[386,409,"APNPNSKGVLMFKKRRRRARKYTL"],[484,507,"LPDTTGKGALMFAKRRERMDQITA"],[865,888,"LPGMSGRGAQLFAKRQSRMEKYVV"]]},{"c":"QP[AP][AFP]Ω","u":5,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Four 5-residue motifs in the proline/polar-rich disordered region (three arrayed in near-tandem 6-residue phase at 646-662 and a fourth dispersed copy at 790-794) sharing an invariant N-terminal QP dipeptide and C-terminal aromatic anchor (W/Y/F).","i":[[645,649,"QPPPW"],[651,655,"QPAPW"],[657,661,"QPAFY"],[788,792,"QPPAF"]]}],"s":"MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKIRNQSKASGSGLCEGDEVVSINGNPCADLTYPEVIKLMESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQIRPATKTQCTEFFLAPVKTEVPLAENQRSGPDCAGSLKEETGPSYQRAPQMPDSQRGRVAEELILREKVEAVQPGPVVELQLSLSQERHKGASGPLVALPGAEKSKSPDPDPNLSHDRIVHINSIPTNEKADPFLRSSKIIQISSGRELRVIQESEAGDAGLPRVEVILDCSDRQKTEGCRLQAGKECVDSPVEGGQSEAPPSLVSFAVSSEGTEQGEDPRSEKDHSRPHKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELEREADEEEEGDKEDTCEVAFLGASESEVDEELLSDVDDNTQVVNFDWDSGLVDIEKKLNRGDKMEMLPDTTGKGALMFAKRRERMDQITAQKEEDKVGGTPSREQDAAQTDGLRTTTSYQRKEEESVRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGSVNQPATPFSPTRNMTSPIADFPAPPPYSAVTPPPDAFSRGVSSPIAGPAQPPPWPQPAPWSQPAFYDSSERIASRDERISVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVWSPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPTVSTPTVNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAALKSQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMKQALPPRPVNAASPTNVQASSVYSVPAYTSPPSFFAEASSPVSASPVPVGIPTSPKQESASSSYFVAPRPKFSAKKSGVTIQVWKPSVVEE"},{"id":"SEQ_01927","a":"Q9Y2Y4","g":"ZBTB32","d":"Zinc finger and BTB domain-containing protein 32","L":487,"m":[{"c":"P[YF]xCS[LV]C[GP]x[RG]xxxxxxMxxHφRxH[GST]x","u":26,"sp":"tandem","x":"structured_like","cf":"high","why":"Three tandem 26-aa C2H2-like repeats separated by 1-2 aa gaps, strongly anchored by invariant P, CS[LV]C, internal M, and HφRxH positions across all copies.","i":[[372,397,"PYACSVCGKRFSLKHQMETHYRVHTG"],[400,425,"PFSCSLCPQRSRDFSAMTKHLRTHGA"],[427,452,"PYRCSLCGAGCPSLASMQAHMRGHSP"]]}],"s":"MSLPPIRLPSPYGSDRLVQLAARLRPALCDTLITVGSQEFPAHSLVLAGVSQQLGRRGQWALGEGISPSTFAQLLNFVYGESVELQPGELRPLQEAARALGVQSLEEACWRARGDRAKKPDPGLKKHQEEPEKPSRNPERELGDPGEKQKPEQVSRTGGREQEMLHKHSPPRGRPEMAGATQEAQQEQTRSKEKRLQAPVGQRGADGKHGVLTWLRENPGGSEESLRKLPGPLPPAGSLQTSVTPRPSWAEAPWLVGGQPALWSILLMPPRYGIPFYHSTPTTGAWQEVWREQRIPLSLNAPKGLWSQNQLASSSPTPGSLPQGPAQLSPGEMEESDQGHTGALATCAGHEDKAGCPPRPHPPPAPPARSRPYACSVCGKRFSLKHQMETHYRVHTGEKPFSCSLCPQRSRDFSAMTKHLRTHGAAPYRCSLCGAGCPSLASMQAHMRGHSPSQLPPGWTIRSTFLYSSSRPSRPSTSPCCPSSSTT"},{"id":"SEQ_01935","a":"Q9H5V7","g":"IKZF5","d":"Zinc finger protein Pegasus","L":419,"m":[{"c":"CxxCxxxxxxxxx[LYF]xxH(x){3,5}H","u":"21-23","sp":"dispersed","x":"structured_like","cf":"high","why":"Five 21-23 aa C2H2-type repeats defined by invariant CxxC and H(x){3,5}H coordination motifs plus a conserved hydrophobic/aromatic [LYF] core anchor three residues before the first histidine, arranged in an N-proximal triplet and a C-terminal pair separated by a central disordered region.","i":[[84,104,"CRYCNYASKGTARLIEHIRIH"],[112,132,"CHLCPFASAYERHLEAHMRSH"],[140,161,"CELCSFRCSDRSNLSHHRRRKH"],[366,386,"CQHCDMYFADNILYTIHMGCH"],[394,416,"CNICGCKCKNKYDFACHFARGQH"]]}],"s":"MGEKKPEPLDFVKDFQEYLTQQTHHVNMISGSVSGDKEAEALQGAGTDGDQNGLDHPSVEVSLDENSGMLVDGFERTFDGKLKCRYCNYASKGTARLIEHIRIHTGEKPHRCHLCPFASAYERHLEAHMRSHTGEKPYKCELCSFRCSDRSNLSHHRRRKHKMVPIKGTRSSLSSKKMWGVLQKKTSNLGYSRRALINLSPPSMVVQKPDYLNDFTHEIPNIQTDSYESMAKTTPTGGLPRDPQELMVDNPLNQLSTLAGQLSSLPPENQNPASPDVVPCPDEKPFMIQQPSTQAVVSAVSASIPQSSSPTSPEPRPSHSQRNYSPVAGPSSEPSAHTSTPSIGNSQPSTPAPALPVQDPQLLHHCQHCDMYFADNILYTIHMGCHGYENPFQCNICGCKCKNKYDFACHFARGQHNQH"},{"id":"SEQ_01958","a":"Q14524","g":"SCN5A","d":"Sodium channel protein type 5 subunit alpha","L":2016,"m":[{"c":"IxxxIx[LT][NS]xxxψ[AM]x[EH]x(x){15,23}Ω[TV]xExxφKφφA(x){9,14}W[NC][WI][LF]D[FS]xψψxψ[SA]φ(x){13,22}RxφRφ[LG]Rx[LF]+xφxxφx[GT]ψ[KRN][TV]ψψx[AI]ψxx[SA]ψxxψx[ND]ψxψψxφφxφxψΩ[AS]ψφGψ[QNA][LN]F(x){33,101}W(x){15,35}φ[IL]φFxxφψφφ[GS]x[FL]φx[LV]N[LM]φ[LI][AG]ψψφxxΩ","u":"220-280","sp":"dispersed","x":"structured_like","cf":"high","why":"Four large homologous hydrophobic-rich domains (220-280 aa) dispersed across the sequence and separated by variable polar linkers (60-306 aa). Each copy shares six conserved hydrophobic/amphipathic blocks anchored by invariant I, E, K, A, W, D, periodic RxxRxxRxx+ basic repeats, GxxxF, a loop W, and a C-terminal F..N..Ω signature.","i":[[137,416,"IMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAY"],[723,942,"ITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSF"],[1211,1473,"IIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNF"],[1534,1775,"IMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENF"]]}],"s":"MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV"},{"id":"SEQ_01965","a":"A6NEH6","g":"TMEM247","d":"Transmembrane protein 247","L":219,"m":[{"c":"R[QE]RQHEVVMEQLQ","u":13,"sp":"tandem","x":"mixed","cf":"high","why":"Direct head-to-tail 13-residue tandem duplication sharing 12 of 13 identical positions (conserved R, Q, H, E, VVM, and QL anchors with only a conservative Q/E substitution at position 2).","i":[[127,139,"RQRQHEVVMEQLQ"],[140,152,"RERQHEVVMEQLQ"]]}],"s":"MAAEDREMMEARGAGESCPTFPKMVPGDSKSEGKPRAYLEAESQKPDSSYDYLEEMEACEDGGCQGPLKSLSPKSCRATKGQAGDGPKPAELPPTPGTERNPEMELEKVRMEFELTRLKYLHEKNQRQRQHEVVMEQLQRERQHEVVMEQLQQEAAPRLFSGGLQNFLLPQNQFAMFLYCFIFIHIIYVTKEMVFFLFAKHYLFCIAAILLCLIKTFWS"},{"id":"SEQ_01981","a":"Q7L311","g":"ARMCX2","d":"Armadillo repeat-containing X-linked protein 2","L":632,"m":[{"c":"[PT][KTE]xA[EA]AP","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five clustered 7-residue repeats in the central proline/alanine/threonine-rich disordered region sharing a [PT] N-terminal cap, polar/charged position 2, fixed A4, [EA]5, and invariant AP C-terminal anchor.","i":[[161,167,"PKVAEAP"],[184,190,"PTEAAAP"],[203,209,"TKVAEAP"],[215,221,"TEAAEAP"],[226,232,"PTGAAAP"]]},{"c":"x-xIxxψxxLxxψφxψψoK[ST]D(x){0,1}P[FH]I[QK][QE]xALψ[TA]ψoNxxx(x){0,1}Yxx[NQ]","u":42,"sp":"tandem","x":"structured_like","cf":"high","why":"Two strongly conserved 42-residue head-to-tail tandem alpha-helical repeats within the C-terminal structured domain sharing phased aliphatic core positions, a K[ST]D(x){0,1}P[FH]I inter-helical turn, and an ALψxψoN...Y C-terminal helix.","i":[[379,420,"IDEILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCN"],[421,462,"QETIRKLGGLPIIANMINKTDPHIKEKALMAMNNLSENYENQ"]]}],"s":"MSRVRDAGCVAAGIVIGAGAWYCVYKYTRGRDQTKKRMAKPKNRAVAGTGARARAGLRAGFTIDLGSGFSPPTPVRAEAEDRAQDEASALDTVGAEAVAPAASSAEAQSGAGSQAQEADGAGVGPKAESVVGAAMASAIAPPPGVTEALGAAEAPAMAGAPKVAEAPREAETSRAAVPPGTVVPTEAAAPTEVTEGPGVAAPTKVAEAPGVASPTEAAEAPVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKATPGAHTGAIPKATSATGAVPKGGGKGVTRSRNGGKGKGKKSKVEVDELGMGFRPGDGAAAAAAASANGGQAFLAEVPDSEEGESGWTDTESDSDSEPETQRRGRGRRPVAMQKRPFPYEIDEILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQETIRKLGGLPIIANMINKTDPHIKEKALMAMNNLSENYENQGRLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANFFRLLSQGGGKIKVEILKILSNFAENPDMLKKLLSTQVPASFSSLYNSYVESEILINALTLFEIIYDNLRAEVFNYREFNKGSLFYLCTTSGVCVKKIRALANHHDLLVKVKVIKLVNKF"},{"id":"SEQ_01983","a":"Q9NYZ3","g":"GTSE1","d":"G2 and S phase-expressed protein 1","L":739,"m":[{"c":"[PQ]LI[DQ][LF]","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five clustered copies of a 5-residue [PQ]LI[DQ][LF] short linear motif in the C-terminal disordered tail (including one direct tandem pair PLIDL-PLIDF and one near-tandem pair QLIDL-SS-PLIQL) anchored by an invariant LI hydrophobic core.","i":[[663,667,"PLIDL"],[668,672,"PLIDF"],[688,692,"PLIDL"],[712,716,"QLIDL"],[719,723,"PLIQL"]]}],"s":"MEGGGGRDEPSACRAGDVNMDDPKKEDILLLADEKFDFDLSLSSSSANEDDEVFFGPFGHKERCIAASLELNNPVPEQPPLPTSESPFAWSPLAGEKFVEVYKEAHLLALHIESSSRNQAAQAAKPEDPRSQGVERFIQESKLKINLFEKEKEMKKSPTSLKRETYYLSDSPLLGPPVGEPRLLASSPALPSSGAQARLTRAPGPPHSAHALPRESCTAHAASQAATQRKPGTKLLLPRAASVRGRSIPGAAEKPKKEIPASPSRTKIPAEKESHRDVLPDKPAPGAVNVPAAGSHLGQGKRAIPVPNKLGLKKTLLKAPGSTSNLARKSSSGPVWSGASSACTSPAVGKAKSSEFASIPANSSRPLSNISKSGRMGPAMLRPALPAGPVGASSWQAKRVDVSELAAEQLTAPPSASPTQPQTPEGGGQWLNSSCAWSESSQLNKTRSIRRRDSCLNSKTKVMPTPTNQFKIPKFSIGDSPDSSTPKLSRAQRPQSCTSVGRVTVHSTPVRRSSGPAPQSLLSAWRVSALPTPASRRCSGLPPMTPKTMPRAVGSPLCVPARRRSSEPRKNSAMRTEPTRESNRKTDSRLVDVSPDRGSPPSRVPQALNFSPEESDSTFSKSTATEVAREEAKPGGDAAPSEALLVDIKLEPLAVTPDAASQPLIDLPLIDFCDTPEAHVAVGSESRPLIDLMTNTPDMNKNVAKPSPVVGQLIDLSSPLIQLSPEADKENVDSPLLKF"},{"id":"SEQ_01991","a":"Q659C4","g":"LARP1B","d":"La-related protein 1B","L":914,"m":[{"c":"[QY][EG]ψ[EN]xφΩ[RA]Ωφ[SK]Ωx[LQ]x[DK]x[FQ]xxxxxxx[FE]xxx[AST]x[EK][DR]φ[EK]xxxx","u":39,"sp":"tandem","x":"structured_like","cf":"high","why":"Three head-to-tail tandem 39-aa helical repeats in the C-terminal structured region (726-842) sharing a strongly conserved aromatic/hydrophobic N-terminal core ([QY][EG]ψ[EN]xφΩ[RA]Ωφ[SK]Ω, including YGLE and LFRF submotifs) and amphipathic C-terminal positions.","i":[[732,770,"QEMNTLFRFWSFFLRDHFNKKMYEEFRQLAWEDAKENYR"],[771,809,"YGLECLFRFYSYGLEKKFRREIFQDFQEETKKDYESGQL"],[810,848,"YGLEKFWAYLKYSQSKTQSIDPKLQEYLCSFKRLEDFRV"]]}],"s":"MENWPTPSELVNTGFQSVLSQGNKKPQNRKEKEEKVEKRSNSDSKENRETKLNGPGENVSEDEAQSSNQRKRANKHKWVPLHLDVVRSESQERPGSRNSSRCQPEANKPTHNNRRNDTRSWKRDREKRDDQDDVSSVRSEGGNIRGSFRGRGRGRGRGRGRGRGNPRLNFDYSYGYQEHGERTDQPFQTELNTSMMYYYDDGTGVQVYPVEEALLKEYIKRQIEYYFSVENLERDFFLRGKMDEQGFLPISLIAGFQRVQALTTNLNLILEALKDSTEVEIVDEKMRKKIEPEKWPIPGPPPRSVPPTDFSQLIDCPEFVPGQAFCSHTESAPNSPRIGSPLSPKKNSETSILQAMSRGLSTSLPDLDSEPWIEVKKRHQPAPVKLRESVSVPEGSLNQLCSSEEPEQEELDFLFDEEIEQIGRKNTFTDWSDNDSDYEIDDQDLNKILIVTQTPPYVKKHPGGDRTGTHMSRAKITSELAKVINDGLYYYEQDLWMEEDENKHTAIKQEVENFKKLNLISKEQFENLTPELPFEPNQEVPVAPSQSRQGGVQGVLHIPKKDLTDELAQKLFDVSEITSAAMVHSLPTAVPESPRIHPTRTPKTPRTPRLQDPNKTPRFYPVVKEPKAIDVKSPRKRKTRHSTNPPLECHVGWVMDSRDRGPGTSSVSTSNASPSEGAPLAGSYGCTPHSFPKFQHPSHELLKENGFTQQVYHKYRRRCLSERKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFRQLAWEDAKENYRYGLECLFRFYSYGLEKKFRREIFQDFQEETKKDYESGQLYGLEKFWAYLKYSQSKTQSIDPKLQEYLCSFKRLEDFRVDPPISDEFGRKRHSSTSGEESNRHRLPPNSSTKPPNAAKPTSTSELQVPINSPRRNISPESSDNSH"},{"id":"SEQ_02001","a":"Q9Y2X9","g":"ZNF281","d":"Zinc finger protein 281","L":895,"m":[{"c":"+P[HFY]xC[DS][HQT]CoxxFxx[SKT][YD]xψx+Hx[KRL][IT][HC]","u":25,"sp":"periodic","x":"structured_like","cf":"high","why":"Four 25-aa cysteine/histidine-anchored repeats (259-367) separated by regular 3-aa [TS][GR]E linkers, with invariant P, CxxC, F, ψ, +H, and C-terminal [HC] positions.","i":[[259,283,"KPHICDHCSAAFRSSYHLRRHVLIH"],[287,311,"RPFQCSQCSMGFIQKYLLQRHEKIH"],[315,339,"KPFGCDQCSMKFIQKYHMERHKRTH"],[343,367,"KPYKCDTCQQYFSRTDRLLKHRRTC"]]},{"c":"x[PS]SQ[EK]L(x){4,5}xQK[ND]ψEx[SR][ST]xΩQ","u":"22-23","sp":"tandem","x":"disordered_like","cf":"high","why":"Three head-to-tail tandem 22-23 aa repeats in the C-terminal disordered region (760-827) anchored by bipartite conserved [PS]SQ[EK]L and QK[ND]ψEx[SR][ST]xΩQ motifs across a 4-5 residue internal linker.","i":[[760,782,"TPSQELDDLIDSQKNLETSSAFQ"],[783,804,"SSSQKLTSQKEQKNLESSTGFQ"],[805,827,"IPSQELASQIDPQKDIEPRTTYQ"]]}],"s":"MKIGSGFLSGGGGTGSSGGSGSGGGGSGGGGGGGSSGRRAEMEPTFPQGMVMFNHRLPPVTSFTRPAGSAAPPPQCVLSSSTSAAPAAEPPPPPAPDMTFKKEPAASAAAFPSQRTSWGFLQSLVSIKQEKPADPEEQQSHHHHHHHHYGGLFAGAEERSPGLGGGEGGSHGVIQDLSILHQHVQQQPAQHHRDVLLSSSSRTDDHHGTEEPKQDTNVKKAKRPKPESQGIKAKRKPSASSKPSLVGDGEGAILSPSQKPHICDHCSAAFRSSYHLRRHVLIHTGERPFQCSQCSMGFIQKYLLQRHEKIHSREKPFGCDQCSMKFIQKYHMERHKRTHSGEKPYKCDTCQQYFSRTDRLLKHRRTCGEVIVKGATSAEPGSSNHTNMGNLAVLSQGNTSSSRRKTKSKSIAIENKEQKTGKTNESQISNNINMQSYSVEMPTVSSSGGIIGTGIDELQKRVPKLIFKKGSRKNTDKNYLNFVSPLPDIVGQKSLSGKPSGSLGIVSNNSVETIGLLQSTSGKQGQISSNYDDAMQFSKKRRYLPTASSNSAFSINVGHMVSQQSVIQSAGVSVLDNEAPLSLIDSSALNAEIKSCHDKSGIPDEVLQSILDQYSNKSESQKEDPFNIAEPRVDLHTSGEHSELVQEENLSPGTQTPSNDKASMLQEYSKYLQQAFEKSTNASFTLGHGFQFVSLSSPLHNHTLFPEKQIYTTSPLECGFGQSVTSVLPSSLPKPPFGMLFGSQPGLYLSALDATHQQLTPSQELDDLIDSQKNLETSSAFQSSSQKLTSQKEQKNLESSTGFQIPSQELASQIDPQKDIEPRTTYQIENFAQAFGSQFKSGSRVPMTFITNSNGEVDHRVRTSVSDFSGYTNMMSDVSEPCSTRVKTPTSQSYR"},{"id":"SEQ_02003","a":"Q8NHM5","g":"KDM2B","d":"Lysine-specific demethylase 2B","L":1336,"m":[{"c":"[LI]x[LV]xxxx(x){0,1}ψxxxxxxxxxxxx(x){0,6}xxx","u":"24-30","sp":"tandem","x":"structured_like","cf":"high","why":"C-terminal structured array of eight 24-30 aa leucine-rich repeats organized into two head-to-tail tandem blocks of four units separated by a single 16-aa linker (1202-1217). Every repeat preserves the N-terminal [LI]x[LV] beta-strand motif, a 4-5 residue turn (containing Cys in five copies), a conserved aliphatic core residue (ψ), and phased amphipathic helix hydrophobics.","i":[[1105,1128,"IDLNHCKSITPLMLSGIIRRQPVS"],[1129,1153,"LDLSWTNISKKQLSWLINRLPGLRD"],[1154,1177,"LVLSGCSWIAVSALCSSSCPLLRT"],[1178,1201,"LDVQWVEGLKDAQMRDLLSPPTDN"],[1218,1242,"LRLAGLDITDASLRLIIRHMPLLSK"],[1243,1272,"LHLSYCNHVTDQSINLLTAVGTTTRDSLTE"],[1273,1297,"INLSDCNKVTDQCLSFFKRCGNICH"],[1298,1322,"IDLRYCKQVTKEGCEQFIAEMSVSV"]]}],"s":"MAGPQMGGSAEDHPPRKRHAAEKQKKKTVIYTKCFEFESATQRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKNRAVGRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRASSLQTSPGSSSHLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSVSVQFGQVEEKLLQKLS"},{"id":"SEQ_02026","a":"Q9H0D2","g":"ZNF541","d":"Zinc finger protein 541","L":1346,"m":[{"c":"C(x){2,4}CxxxΩxxxxxxxxH[MY]xxH","u":"21-23","sp":"dispersed","x":"structured_like","cf":"high","why":"Five copies (an N-terminal cluster of three separated by 7-aa linkers plus two C-terminal dispersed copies) share an invariant C-x(2,4)-C N-terminal pair, a conserved central aromatic position (F/Y), and an invariant H-[MY]-x-x-H C-terminal anchor.","i":[[142,162,"CSLCGKVFSSASSLSKHYLTH"],[170,190,"CKICSKAFKRQDHLTGHMLTH"],[198,220,"CIEQGCSKSYCDYRSLRRHYEVH"],[840,860,"CKNCSQMFYTEKGLSSHMCFH"],[1291,1311,"CRECERVFDKIKSRNAHMKRH"]]}],"s":"MDQYSLGDEGALPSEMHLPSFSESQGLNCSDTLNRDLGPNTRGFLYAGLSGLDPDPSLPTPDMSSEVLEDNLDTLSLYSGKDSDSVKLLEEYADSESQASLQDLGLGVLKAKEADEGGRATSGSARKGKRQHSSPQNPLLDCSLCGKVFSSASSLSKHYLTHSQERKHVCKICSKAFKRQDHLTGHMLTHQKTKPFVCIEQGCSKSYCDYRSLRRHYEVHHGLCILKEAPPEEEACGDSPHAHESAGQPPPSSLRSLVPPEARSPGSLLPHRDLLRRIVSSIVHQKTPSPGPAPAGASDSEGRNTACPCPASSGSSSCTPAGPHAAPAALDTELPEEPCLPQKEPATDVFTAPNSRAAENGAPDPPEPEPDTALLQARSTAECWPEGGSVPACLPLFRGQTVPASSQPSSHSFQWLRNLPGCPKSKGNNVFVVHKPSAVPSREGSESGPGPSSGSPSEESPPGPGGGLEDALPFPAALLRVPAEAPSDPRSASGEDDPCAPKKVKVDCDSFLCQNPGEPGLQEAQKAGGLPADASPLFRQLFLKSQEPLVSHEQMQVFQMITKSQRIFSHAQVAAVSSQLPAPEGKPAALRPLQGPWPQQPPPLAPAVDSLHAGPGNPEAEGSPARRRKTTPGVPREASPGSTRRDAKGGLKVAAVPTPLAAPSLDPSRNPDISSLAKQLRSSKGTLDLEDIFPSTGQRQTQLGGEEPPGASLPGKQAPAENGAASRITKGEKGPACSRGGGYRLLGNPRAPRFSGFRKEKAKMDMCCAASPSQVAMASFSSAGPPADPSKSKLTIFSRIQGGNIYRLPHPVKEENVAGRGNQQNGSPTDWTKPRSTFVCKNCSQMFYTEKGLSSHMCFHSDQWPSPRGKQEPQVFGTEFCKPLRQVLRPEGDRHSPPGTKKPLDPTAAAPLVVPQSIPVVPVTRHIGSMAMGQEKDGEERDSKESSQQRKRKKRPPPSTAGEPGPAGCHQSRLRSPMFLVDCLLKGLFQCSPYTPPPMLSPIREGSGVYFNTLCSTSTQASPDQLISSMLDQVDGSFGICVVKDDTKISIEPHINIGSRFQAEIPELQERSLAGTDEHVASLVWKPWGDMMISSETQDRVTELCNVACSSVMPGGGTNLELALHCLHEAQGNVQVALETLLLRGPHKPRTHLLADYRYTGSDVWTPIEKRLFKKAFYAHKKDFYLIHKMIQTKTVAQCVEYYYIWKKMIKFDCGRAPGLEKRVKREPEEVERTEEKVPCSPRERPSHHPTPKLKTKSYRRESILSSSPNAGSKRTPELLGSAESQGIFPCRECERVFDKIKSRNAHMKRHRLQDHVEPIIRVKWPVKPFQLKEEELGADIGPLQW"},{"id":"SEQ_02028","a":"Q63HK5","g":"TSHZ3","d":"Teashirt homolog 3","L":1081,"m":[{"c":"[FLY]xCxxCxxxxx[ST]xxxφxxH[LM](x){2,4}H","u":"23-25","sp":"dispersed","x":"structured_like","cf":"high","why":"Five dispersed copies across the N-terminal and C-terminal regions share a conserved [FLY]-x-C-x-x-C N-terminal signature, internal [ST] and hydrophobic positions, and a C-terminal H-[LM]-x(2,4)-H pair.","i":[[214,238,"FRCKDCSAAYDTLVELTVHMNETGH"],[275,299,"LKCMYCGHSFESLQDLSVHMIKTKH"],[386,410,"LKCMECGSSHDTLQELTAHMMVTGH"],[976,998,"FFCNDCASQIRTPSTYISHLESH"],[1041,1064,"YQCKLCNRTFASKHAVKLHLSKTH"]]}],"s":"MPRRKQQAPRRAAAYVSEELKAAALVDEGLDPEEHTADGEPSAKYMCPEKELARACPSYQNSPAAEFSCHEMDSESHISETSDRMADFESGSIKNEEETKEVTVPLEDTTVSDSLEQMKAVYNNFLSNSYWSNLNLNLHQPSSEKNNGSSSSSSSSSSSCGSGSFDWHQSAMAKTLQQVSQSRMLPEPSLFSTVQLYRQSSKLYGSIFTGASKFRCKDCSAAYDTLVELTVHMNETGHYRDDNHETDNNNPKRWSKPRKRSLLEMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVTPVAAKIIPATRKKASLELELPSSPDSTGGTPKATISDTNDALQKNSNPYITPNNRYGHQNGASYAWHFEARKSQILKCMECGSSHDTLQELTAHMMVTGHFIKVTNSAMKKGKPIVETPVTPTITTLLDEKVQSVPLAATTFTSPSNTPASISPKLNVEVKKEVDKEKAVTDEKPKQKDKPGEEEEKCDISSKYHYLTENDLEESPKGGLDILKSLENTVTSAINKAQNGTPSWGGYPSIHAAYQLPNMMKLSLGSSGKSTPLKPMFGNSEIVSPTKNQTLVSPPSSQTSPMPKTNFHAMEELVKKVTEKVAKVEEKMKEPDGKLSPPKRATPSPCSSEVGEPIKMEASSDGGFRSQENSPSPPRDGCKDGSPLAEPVENGKELVKPLASSLSGSTAIITDHPPEQPFVNPLSALQSVMNIHLGKAAKPSLPALDPMSMLFKMSNSLAEKAAVATPPPLQSKKADHLDRYFYHVNNDQPIDLTKGKSDKGCSLGSVLLSPTSTAPATSSSTVTTAKTSAVVSFMSNSPLRENALSDISDMLKNLTESHTSKSSTPSSISEKSDIDGATLEEAEESTPAQKRKGRQSNWNPQHLLILQAQFAASLRQTSEGKYIMSDLSPQERMHISRFTGLSMTTISHWLANVKYQLRRTGGTKFLKNLDTGHPVFFCNDCASQIRTPSTYISHLESHLGFRLRDLSKLSTEQINSQIAQTKSPSEKMVTSSPEEDLGTSYQCKLCNRTFASKHAVKLHLSKTHGKSPEDHLLYVSELEKQ"},{"id":"SEQ_02037","a":"Q5JYT7","g":"KIAA1755","d":"Uncharacterized protein KIAA1755","L":1200,"m":[{"c":"φx[RE]φψ[DNS][SQ][GD]F[QE]G[DN]x[LV]","u":14,"sp":"periodic","x":"structured_like","cf":"high","why":"Three copies of a conserved 14-residue core motif occur at regular ~115 aa intervals (linkers of 103 and 100 aa) across the N-terminal structured region (residues 32-276), anchored by invariant F and G residues within a [GD]F[QE]G[DN] turn preceded by conserved hydrophobic/aliphatic positions.","i":[[32,45,"VFRLLDSGFQGDGL"],[149,162,"WLEAINSDFEGNPL"],[263,276,"MDEVVSQDFEGDYV"]]}],"s":"MDPPSLDTAIQHALAGLYPPFEATAPTVLGQVFRLLDSGFQGDGLSFLLDFLIPAKRLCEQVREAACAPYSHCLFLHEGWPLCLRDEVVVHLAPLNPLLLRQGDFYLQVEPQEEQSVCIMIKCLSLDLCTVDKKPVPEPAYPILFTQEWLEAINSDFEGNPLHNCLVASENGIAPVPWTKITSPEFVDDRPQVVNALCQAWGPLPLEALDLSSPQELHQASSPDNQVLPAQSLAKGKGRTYGSKYPGLIKVEQARCGEVAFRMDEVVSQDFEGDYVALLGFSQESRGESPSREAGTSSGCTSGALEEIAGTKETPLFQKILPLSEANEGPSLGNRACTKPESSEERPYNLGFRRKVNLKAPTHNSERPPQGSYMNVLEDALDCASGLRAGVSQEPAASKMQGPLGNPENMVQLRPGPRQASSPRLSPASPAAAASETKIEVKTKERNGRLPKPMPCPSRNTSSPEPPTPGLKFSFLRGQRQPSVTPEKASLQHNGPWKVLCSLYSPKPNRAKSLGKAGTTQTKTSGPATAPSPLTEEKAALPEASAGSPERGPTLEEEPPGPEPRIGALGVKVFRSRIACLPGGRDRAGRPLLLVSTTEGAWEAPWCTVSEVTKLLSYLCTIPRPEDKAKGLAVLIDARRQPPQPGLVSALQATQAQVPASIRAILFLGEKEAALQLQTLPDVQVEVLTSLKALSHHVDPSQLPAVLEGPFPYCHTEWVHFFQKLDPFLADLHQASSLLQASIEEFEKADPPGGMQEATRCLSKSKELMEAVLRDPGLLGLQREGGATLARLQHDASRLDFSPDVRSHLAAATALYSLVDEQLHVLVTASNSLLGKLELRVRLGRLEAAIHQVSDWMEQEGRRCLQSLTPKDGSLETVEKAHAEFENFFLQAAAQYRRGLELSKQAAQLGATARGAGEAERAEFPELAAFASTQRAFQAELTHFYMAAERQRTDLETLLHLHRFCKRMTWFHMDCQDLMAQLRLDKTSRVSPGDQRRLHRYLQRLASEFPAEKLAAVGLQVASLSRAGLGQELWEEARIRHEEIRMLLEKALTHSSCPEAPAAHSARPERRGVAAKGQGVSVEVTSKGRWDQPPLDSLGMDHLPKSYWPPGPPRGEQNRTFQAGSPPQEAGQAAEAEDGKGSHKLPDPAREHLLATTFFRQQPPRQSQVPRLTGGSFSSEGTDSQTSLEDSPQTSPLASL"},{"id":"SEQ_02059","a":"Q9H706","g":"GAREM1","d":"GRB2-associated and regulator of MAPK protein 1","L":876,"m":[{"c":"P[PSA]ψPP+","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed copies in the C-terminal disordered region share invariant prolines at positions 1, 4, and 5, a conserved large aliphatic residue (V/I/L) at position 3, a small residue (P/S/A) at position 2, and a C-terminal basic anchor (K/R) at position 6.","i":[[514,519,"PPVPPK"],[533,538,"PPVPPR"],[547,552,"PSIPPR"],[723,728,"PALPPR"]]}],"s":"MDPAPSLGCSLKDVKWSSVAVPLDLLVSTYRLPQIARLDNGECVEGLRENDYLLIHSCRQWTTITAHSLEEGHYVIGPKIEIPVHYAGQFKLLEQDRDIKEPVQYFNSVEEVAKAFPERVYVMEDITFNVKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTFKEKSRLNTIFKKIGKLNSISKLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLELQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNPYDLHFIREGHRYKFVNIQTKTVVVCCVLRNNKILPMHFPLHLTVPKFSLPEHLVKGESWPETLVHHWLGICQEQFDIDEYSRAVRDVKTDWNEECKSPKKGRCSGHNHVPNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLGGDWAPFPHDILPYQDSGDSGSDYLFPEASEESAGIPGKSELPYEELWLEEGKPSHQPLTRSLSEKNRCDQFRGSVRSKCATSPLPIPGTLGAAVKSSDTALPPPPVPPKSEAVREECRLLNAPPVPPRSAKPLSTSPSIPPRTVKPARQQTRSPSPTLSYYSSGLHNISVTKTDTNPSESTPVSCYPCNRVKTDSVDLKSPFGSPSAEAVSSRLSWPNHYSGASESQTRSDFLLDPSRSYSYPRQKTPGTPKRNCPAPFDFDGCELLASPTSPVTAEFSSSVSGCPKSASYSLESTDVKSLAAGVTKQSTSCPALPPRAPKLVEEKVASETSPLPLKIDGAEEDPKSGSPDLSEDQYFVKKGMQDIFSASYPFSSPLHLQLAPRSCGDGSPWQPPADLSGLSIEEVSKSLRFIGLSEDVISFFVTEKIDGNLLVQLTEEILSEDFKLSKLQVKKIMQFINGWRPKI"},{"id":"SEQ_02070","a":"Q96EK2","g":"PHF21B","d":"PHD finger protein 21B","L":531,"m":[{"c":"[RE][DS]RPP[KT][QE][PE]","u":8,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 8-aa copies in the N-terminal Pro/polar-rich disordered region share an invariant RPP core flanked by constrained charged/polar positions ([RE][DS] N-terminally and [KT][QE][PE] C-terminally, including 6/8 identity between the proximal C-terminal pair ESRPPTEE and EDRPPTQE and 5/8 identity between RDRPPKQP and EDRPPTQE).","i":[[88,95,"RDRPPKQP"],[247,254,"ESRPPTEE"],[267,274,"EDRPPTQE"]]}],"s":"MELQSRPEALAVELARHQNGDLKKQLHERQPRIAALSDKQALGTITAVPVTGPQVSSLQRLAGQGAAVLPQVRPKTLIPDSLPVAPGRDRPPKQPPTFQKATVVSVKNPSPALPTANNTVSHVPAPGSQPQALAEPAALASPLSSAGVAYAIISTSPSNAAAMAPSTAVSVVSDSIKVQPLLISADNKPPPRLLSSPHPATHHCPLHPSSLPLTPPSPSLSPSPLHGIFQVIIIQPQVQTQPESTAESRPPTEEPSQGAQATKKKKEDRPPTQENPEKIAFMVALGLVTTEHLEEIQSKRQERKRRSTANPAYSGLLETERKRLASNYLNNPLFLTARANEDPCWKNEITHDEHCAACKRGANLQPCGTCPGAYHLSCLEPPLKTAPKGVWVCPRCQQKALKKDEGVPWTGMLAIVHSYVTHKTVKEEEKQKLLQRGSELQNEHQQLEERDRRLASAVQKCLELKTSLLARQRGTQSSLDRLRALLRLIQGEQLLQVTMTTTSPAPLLAGPWTKPSVAATHPTVQHPQGHN"},{"id":"SEQ_02076","a":"Q6WCQ1","g":"MPRIP","d":"Myosin phosphatase Rho-interacting protein","L":1025,"m":[{"c":"GWL(x){7,17}[KQ]W[QK]+[RH]ΩFψLφ-[HQ][GS]LxxYxx(x){9,10}GxI[ND]ψo[QA]C[TY]DVx-xxxxxxxxF(x){3,5}T[PK]E[KG]ExxψxATxxIxxxWψ[EQ]xψM","u":"88-99","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of an 88-99 aa globular domain separated by a long disordered linker, sharing conserved N-terminal GWL, a 19-aa [KQ]W[QK]+[RH]ΩFψLφ-[HQ][GS]LxxYxx core, GxI[ND]ψo[QA]C[TY]DV motif, F(x){3,5}T[PK]E[KG]E turn, and C-terminal amphipathic helix (ψxATxxIxxxWψ[EQ]xψM).","i":[[48,146,"GWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQKFSLCILTPEKEHFIRAETKEIVSGWLEMLM"],[392,479,"GWLTKQYEDGQWKKHWFVLADQSLRYYRDSVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIM"]]}],"s":"MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQKFSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVAVTSSSSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSLREPGLESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTPNHRRSQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPDASASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYYRDSVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMKHVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSVIEQVSWDT"},{"id":"SEQ_02084","a":"O60303","g":"KATNIP","d":"Katanin-interacting protein","L":1618,"m":[{"c":"φxφxφx[SAT]oWG[DN]x[WHY]ΩψGL[TN][GE]ψEφφ(x){41,50}W[TL]xP[FI](x){32,38}G[AV]K(x){28,38}IL[FV]","u":"141-154","sp":"dispersed","x":"structured_like","cf":"high","why":"Four large (~141-154 aa) dispersed structured domain repeats separated by variable linkers (~37-402 aa), anchored by an invariant N-terminal φxφxφx[SAT]oWG[DN]x[WHY]ΩψGL[TN][GE]ψEφφ core, internal W[TL]xP[FI], WNY/NYW, and G[AV]K motifs, and a C-terminal IL[FV] signature.","i":[[479,619,"VTMEILSNWGNSWWVGLTEVEFFDLNDTKLYVSPHDVDIRNTATPGELGRLVNRNLAGKKDSSPWTCPFHPPLQLFFVIRNTRQLGDFHLAKIKVRNYWTADGDLDIGAKNVKLYVNRNLIFNGKLDKGDREAPADHSILV"],[977,1126,"LVIDIKSTWGDRHYVGLNGIEIFSSKGEPVQISNIKADPPDINILPAYGKDPRVVTNLIDGVNRTQDDMHVWLAPFTRGRSHSITIDFTHPCHVALIRIWNYNKSRIHSFRGVKDITMLLDTQCIFEGEIAKASGTLAGAPEHFGDTILF"],[1212,1363,"LQLNFTASWGDLHYLGLTGLEVVGKEGQALPIHLHQISASPRDLNELPEYSDDSRALDKLIDGTNITMEDEHMWLIPFSPGLDHVVTIRLDRAESIAGLRFWNYNKSPEDTYRGAKIVHVSLDGLCVSPPEGFLIRKGPGNCHFDFAQEILF"],[1402,1555,"FQFQLLTSWGDPYYIGLTGLELYDERGEKIPLSENNIAAFPDSVNSLEGVGGDVRTPDKLIDQVNDTSDGRHMWLAPILPGLVNRVYVIFDLPTTVSMIKLWNYAKTPHRGVKEFGLLVDDLLVYNGILAMVSHLVGGILPTCEPTVPYHTILF"]]},{"c":"RER[NP][LA]S[AG]xR","u":9,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 9-residue motifs located in the N-terminal and central disordered linker regions, sharing five invariant anchors (R, E, R, S, R) and three constrained two-residue positions ([NP], [LA], [AG]).","i":[[273,281,"RERNLSAKR"],[319,327,"RERPLSATR"],[847,855,"RERPASGRR"]]}],"s":"MDGQTLRKAERSWSCSREKKEGYAKDMVTDFDEKHDEYLILLQQRNRILKHLKSKDPVQLRLEHLEQGFSVYVNGANSELKSSPRKAIHSDFSRSASHTEGTHDYGRRTLFREAEEALRRSSRTAPSKVQRRGWHQKSVQIRTEAGPRLHIEPPVDYSDDFELCGDVTLQANNTSEDRPQELRRSLELSVNLQRKQKDCSSDEYDSIEEDILSEPEPEDPALVGHPRHDRPPSSGDWTQKDVHGEQETEGRSSPGPDTLVVLEFNPASKSHKRERNLSAKRKDNAEVFVPTKPEPNLTPQAPAVFPDQERMCSRPGSRRERPLSATRKTLCEAEYPEEDASAVLQAIQVENAALQRALLSRKAEQPASPLQDAEGPPAKPWTSLLEEKEETLELLPITTATTTQEPAGAAGGARAINQAMDRIGLLGSRQQQKLLKVLQAVESDSAHLGRVVSPTKEQVSDTEDKQRMRADEIKDAIYVTMEILSNWGNSWWVGLTEVEFFDLNDTKLYVSPHDVDIRNTATPGELGRLVNRNLAGKKDSSPWTCPFHPPLQLFFVIRNTRQLGDFHLAKIKVRNYWTADGDLDIGAKNVKLYVNRNLIFNGKLDKGDREAPADHSILVDQKNEKSEQLEEAMNAHSEESKGTHEMAGASGDKELGLGCSPPAETLADAKLSSQGNVSGKRKNSTNCRKDSLSQLEEYLRLSAVPTSMGDMPSAPATSPPVKCPPVHEEPSLIQQLENLMGRKICEPPGKTPSWLQPSPTGKDRKQGGRKPKPLWLSPEKPLAWKGRLPSDDVIGEGPGETEARDKGLRHEPGWGTSRSVNTKERPQRATTKVHSDDSDIFNQPPNRERPASGRRGSRKDAGSSSHGDDQPASREDTWSSRTPSRSRWRSEQEHTLHESWSSLSAFDRSHRGRISNTELPGDILDELLQQKSSRHSDLPPSKKGEQPGLSRGQDGYSGETDAGGDFKIPVLPYGQRLVIDIKSTWGDRHYVGLNGIEIFSSKGEPVQISNIKADPPDINILPAYGKDPRVVTNLIDGVNRTQDDMHVWLAPFTRGRSHSITIDFTHPCHVALIRIWNYNKSRIHSFRGVKDITMLLDTQCIFEGEIAKASGTLAGAPEHFGDTILFTTDDDILEAIFYSDEMFDLDVGSLDSLQDEEAMRRPSTADGEGDERPFTQAGLGADERIPELELPSSSPVPQVTTPEPGIYHGICLQLNFTASWGDLHYLGLTGLEVVGKEGQALPIHLHQISASPRDLNELPEYSDDSRALDKLIDGTNITMEDEHMWLIPFSPGLDHVVTIRLDRAESIAGLRFWNYNKSPEDTYRGAKIVHVSLDGLCVSPPEGFLIRKGPGNCHFDFAQEILFVDYLRAQLLPQPARRLDMRSLECASMDYEAPLMPCGFIFQFQLLTSWGDPYYIGLTGLELYDERGEKIPLSENNIAAFPDSVNSLEGVGGDVRTPDKLIDQVNDTSDGRHMWLAPILPGLVNRVYVIFDLPTTVSMIKLWNYAKTPHRGVKEFGLLVDDLLVYNGILAMVSHLVGGILPTCEPTVPYHTILFTEDRDIRHQEKHTTISNQAEDQDVQMMNENQIITNAKRKQSVVDPALRPKTCISEKETRRRRC"},{"id":"SEQ_02095","a":"Q02952","g":"AKAP12","d":"A-kinase anchor protein 12","L":1782,"m":[{"c":"Wx[SA]φ[KI][KRC]φ[VIG][TSP][PSG]+++x+","u":15,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed 15-residue amphipathic motifs in the central disordered region (residues 610-818) anchored by an invariant N-terminal Trp, two conserved internal hydrophobic positions, a short P/S/G turn, and a C-terminal polybasic +++x+ cluster.","i":[[610,624,"WASFKKMVTPKKRVR"],[679,693,"WEALICVGSSKKRAR"],[759,773,"WESFKRLVTPRKKSK"],[804,818,"WVSIKKFIPGRRKKR"]]},{"c":"G[AD]LN[GS]Q","u":6,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three tandem 6-residue repeats near the N-terminus (residues 80-98, separated by 1 and 0 residues) sharing invariant G, L, N, and Q anchors and tightly constrained [AD] and [GS] positions.","i":[[79,84,"GDLNGQ"],[86,91,"GALNGQ"],[92,97,"GALNSQ"]]},{"c":"[FL]KKφF","u":5,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 5-residue basic-hydrophobic cores (residues 171-520) anchored by invariant KK and C-terminal Phe with flanking bulky hydrophobics, nucleating discrete basic-aromatic islands within an otherwise Phe-depleted disordered region.","i":[[172,176,"FKKVF"],[296,300,"FKKFF"],[516,520,"LKKLF"]]}],"s":"MGAGSSTEQRSPEQPPEGSSTPAEPEPSGGGPSAEAAPDTTADPAIAASDPATKLLQKNGQLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTES"},{"id":"SEQ_02098","a":"Q6DN14","g":"MCTP1","d":"Multiple C2 and transmembrane domain-containing protein 1","L":999,"m":[{"c":"ψxψ[TK]ψxx[GA]xxLxAxDxxGxSDP[YF][VC][KV]φxψ[GN]x(x){4,5}[ST][KH][IT]ψxK[NT]LNPxWx[EK]xφxφxψxxxxxx(x){0,1}ψxψ[KT]φΩDxDx[GD]xx[DA]DFψGxxxψ[DP]LxxψxxxxxxxφxLxx(x){4,10}GxψφLxψxψ","u":"113-119","sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed 113-119 aa structured beta-sandwich-like domain repeats (separated by 90 aa and 43 aa linkers) anchored by invariant/highly conserved motifs including LxAxDxxGxSDP[YF], K[NT]LNPxW, ΩDxD, and [DA]DFψG, flanked by conserved alternating aliphatic beta-strands at both termini.","i":[[263,381,"LDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDPHYPDHDLGIILLSVIL"],[472,584,"VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTL"],[628,743,"LQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKAYVLKNKQLTGPTKGVIYLEIDV"]]}],"s":"MEPRAAAAGEPEPPAASSSFQARLWKNLQLGVGRSKGGGGGRAGGPERRTADTPSPSPPPPVGTGNAPARGSGAGSRWSGFKKRKQVLDRVFSSSQPNLCCSSPEPLEPGGAGRAEQGSTLRRRIREHLLPAVKGPAAASGAAGGTPPGGRSPDSAPSSSSASSSLSSSPQPPPRGDRARDEGARRQGPGAHLCHQKSSSLPGTACLEQLLEPPPPPAEPARSPAESRAPETGEEHGSSQKIINTAGTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDPHYPDHDLGIILLSVILTPKEGESRDVTMLMRKSWKRSSKELSENEVVGSYFSVKSLFWRTCGRPALPVLGFCRAELQNPYCKNVQFQTQSLRLSDLHRKSHLWRGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKAYVLKNKQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQKYIEEENRLSKQLLLRNFIRMKRCVMVLVNAAYYVNSCFDWDSPPRSLAAFVLFLFVVWNFELYMIPLVLLLLLTWNYFLIISGKDNRQRDTVVEDMLEDEEEEDDKDDKDSEKKGFINKIYAIQEVCVSVQNILDEVASFGERIKNTFNWTVPFLSWLAIVALCVFTAILYCIPLRYIVLVWGINKFTKKLRSPYAIDNNELLDFLSRVPSDVQVVQYQELKPDPSHSPYKRKKNNLG"},{"id":"SEQ_02099","a":"Q14160","g":"SCRIB","d":"Protein scribble homolog","L":1655,"m":[{"c":"xLxx[LA]xφxxNx[LI]xxψPxxφxxLx","u":23,"sp":"tandem","x":"structured_like","cf":"high","why":"Head-to-tail tandem array of 15 contiguous 23-aa repeats (residues 37-381) defined by strictly phased hydrophobic/leucine positions alongside conserved N10 and P16 anchors.","i":[[37,59,"SLEELLLDANQLRELPKPFFRLL"],[60,82,"NLRKLGLSDNEIQRLPPEVANFM"],[83,105,"QLVELDVSRNDIPEIPESIKFCK"],[106,128,"ALEIADFSGNPLSRLPDGFTQLR"],[129,151,"SLAHLALNDVSLQALPGDVGNLA"],[152,174,"NLVTLELRENLLKSLPASLSFLV"],[175,197,"KLEQLDLGGNDLEVLPDTLGALP"],[198,220,"NLRELWLDRNQLSALPPELGNLR"],[221,243,"RLVCLDVSENRLEELPAELGGLV"],[244,266,"LLTDLLLSQNLLRRLPDGIGQLK"],[267,289,"QLSILKVDQNRLCEVTEAIGDCE"],[290,312,"NLSELILTENLLMALPRSLGKLT"],[313,335,"KLTNLNVDRNHLEALPPEIGGCV"],[336,358,"ALSVLSLRDNRLAVLPPELAHTT"],[359,381,"ELHVLDVAGNRLQSLPFALTHLN"]]},{"c":"xxφxψx+xx(x){1,2}[GPR]LGφSIxGG(x){11,14}G[IV]F[IV]S+[IV]x[EP]xGxAxRxG(x){1,2}[RQ]VG[DL]+ψLxψN[GQ]xxψxxφxHx[EH]AVx[AL]Lxxxxxxψxψ[LR]ψx[RD]","u":"87-92","sp":"dispersed","x":"structured_like","cf":"high","why":"Four dispersed 87-92 aa structured repeats in the central region sharing highly conserved LGφSIxGG, G[IV]F[IV]S+[IV]x[EP]xGxAxRxG, VG[DL]+ψLxψN, and Hx[EH]AVx[AL]L sequence blocks separated by variable linkers.","i":[[727,813,"LTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWR"],[861,948,"HVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLER"],[1003,1091,"EEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRR"],[1099,1190,"RELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCD"]]},{"c":"Kx[DA]YRA[FL]AA[VL]P[ST][AS]","u":13,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 13-aa motif instances embedded in the proline/serine-enriched C-terminal disordered region, anchored by seven invariant residues (K1, Y4, R5, A6, A8, A9, P11) and five tightly constrained two-choice positions.","i":[[1265,1277,"KLDYRALAAVPSA"],[1318,1330,"KQAYRAFAAVPTS"],[1571,1583,"KFDYRAFAALPSS"]]}],"s":"MLKCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPPSLEDAGQQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSIEGRRSEACPCQPDSGSPLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPSAEAQGGSQQEATTAGGEEDAEEDYQEPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQRLIRKDTPHYKKHFKISKLPQPEAVVALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRGLQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQAYRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLVGADDLRKMQEEEARKLQQKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSPTSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSPAELRALEAEKRALWRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTSTSPGRLPLSGKKFDYRAFAALPSSRPVYDIQSPDFAEELRSLEPSPSPGPQEEDGEVALVLLGRPSPGAVGPEDVALCSSRRPVRPGRRGLGPVPS"},{"id":"SEQ_02111","a":"B4DH59","g":"NBPF26","d":"NBPF family member NBPF26","L":1673,"m":[{"c":"[KW](x){4,23}[EK]ED[QH]x[PA][PST][CG]PRL[SN][RGS][EM]L[LM]-[EV][KVE][EG]PEVLQ-SL[DG][RI]CYSTPS[GSM][CY][LF]E[LQ][TP]D[SL][CGF]Q[PH]Y[RGS]S[ASV][FV]Yx[LF]E[QE][QKE]xψ[GS][LF][AS][LV][DY][MV][DGN][ER][IF]x","u":"75-94","sp":"tandem","x":"mixed","cf":"high","why":"Head-to-tail tandem array of 10 highly conserved 75-94 aa units (preceded by a divergent N-terminal 11th copy at residues 794-865) sharing a gapless 70-aa core anchored by ED, PRL, PEVLQ, CYSTPS, and Q[PH]Y, with either a 5-aa acidic/polar or 24-aa polybasic N-terminal linker segment.","i":[[866,940,"WDQVKKEDHEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIE"],[941,1015,"KYQEVEEDQDPSCPRLSGELLDEKEPEVLQESLDRCYSTPSGCLELTDSCQPYRSAFYILEQQRVGLAVDMDEIE"],[1016,1090,"KYQEVEEDQDPSCPRLSGELLDEKEPEVLQESLDRCYSTPSGCLELTDSCQPYRSAFYILEQQRVGLAVDMDEIE"],[1091,1165,"KYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLGRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIK"],[1166,1240,"KDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIE"],[1241,1334,"KKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQRVGLAVDMDEIE"],[1335,1409,"KYQEVEEDQDPSCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIE"],[1410,1484,"KYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLGRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIK"],[1485,1559,"KDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIE"],[1560,1653,"KKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNSMLMEVEEPEVLQDSLDICYSTPSMYFELPDSFQHYRSVFYSFEEEHISFALYVDNRF"]]},{"c":"PVP[DG][SP]TSSATNVSMVVSAG[HP][WL]S[SG]EKA[EA]ψNILEINE[TK]LRPQL[PA]E[NK]KQQ[LF]RNLKEKCFLTQLAGFLAN[RQ]Q[KN]KYKYEECKDLIK[FS]MLRNERQFKEEKLAEQLKQAEELRQYKVLVH[SA]QERELTQL+EKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPEND[EN]-DDEDVQVE[EV][DA]EKV[LQ][EK]SSAPRE[VM]QK[TA]EE[SK][KE]VPEDSLEECAITCSNSHGP[CY]D[SC]NQPH+[NK][IT]KITFEED[EK]V[ND]STLψ[VG](x){0,2}[ES]SSH[DV]E[CW][QE]DAψ[NH]Iψ","u":"269-271","sp":"tandem","x":"mixed","cf":"high","why":"Large head-to-tail tandem duplication of a 269-271 aa region (~85% sequence identity across the entire span) encompassing N-terminal helical/coiled-coil segments, an acidic linker, and a C-terminal Cys/His-containing module.","i":[[250,520,"PVPDSTSSATNVSMVVSAGHWSSEKAEMNILEINETLRPQLPENKQQLRNLKEKCFLTQLAGFLANRQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLKEKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKTEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTLVVDRESSHDECQDALNIL"],[521,789,"PVPGPTSSATNVSMVVSAGPLSGEKAAINILEINEKLRPQLAEKKQQFRNLKEKCFLTQLAGFLANQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDCNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHII"]]},{"c":"C(x){4,6}Cx[NH][GK][GS][TM]C(x){8,10}CxCxxGF[TL]GxxC","u":"32-35","sp":"periodic","x":"structured_like","cf":"high","why":"Five complete 6-cysteine structured repeats separated by regular 5-7 aa linkers, anchored by strictly conserved cysteines, an NGGTC-like turn, and a C-terminal CxCxxGF[TL]GxxC motif (followed by a truncated 6th copy at residues 227-249).","i":[[28,62,"CRDGYEPCVNKGMCVTYHSGTGYCKCPEGFLGEYC"],[68,101,"CEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDC"],[109,142,"CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC"],[148,179,"CLSHLCANGSTCTTVANQFSCKCLTGFTGQKC"],[186,218,"CDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYC"]]}],"s":"MPALRPALLWALLALWLCWAAPAHALQCRDGYEPCVNKGMCVTYHSGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTPHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHLCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDRLYVPCAHSPCVNGGTCRQTGDFTFECNCLPVPDSTSSATNVSMVVSAGHWSSEKAEMNILEINETLRPQLPENKQQLRNLKEKCFLTQLAGFLANRQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLKEKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVLESSAPREVQKTEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTLVVDRESSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSGEKAAINILEINEKLRPQLAEKKQQFRNLKEKCFLTQLAGFLANQQNKYKYEECKDLIKSMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDCNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYKSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDHEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSGELLDEKEPEVLQESLDRCYSTPSGCLELTDSCQPYRSAFYILEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSGELLDEKEPEVLQESLDRCYSTPSGCLELTDSCQPYRSAFYILEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLGRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLGRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNSMLMEVEEPEVLQDSLDICYSTPSMYFELPDSFQHYRSVFYSFEEEHISFALYVDNRFFTLTVTSLHLVFQMGVIFPQ"},{"id":"SEQ_02112","a":"Q12816","g":"TRO","d":"Trophinin","L":1431,"m":[{"c":"[GSD][GS]x[LP][SGN]T[SN]x[GSC][FY]","u":10,"sp":"tandem","x":"disordered_like","cf":"high","why":"Extensive C-terminal disordered array of 61 ten-residue FG/FS-type repeats (predominantly contiguous head-to-tail tandem blocks interrupted by occasional 8-9 aa shortened variants), anchored by N-terminal G/S residues, a central [LP]-[SGN]-T-[SN] core, and an invariant C-terminal F/Y.","i":[[724,733,"SRGASTRAGF"],[742,751,"NGAPSSSGGF"],[760,769,"GVAPSTSASF"],[778,787,"GGTLSTSSSF"],[796,805,"GCAHSTSTSF"],[814,823,"GGMPCTSASF"],[832,841,"SGPLSTSATF"],[850,859,"GGTLSTTAGF"],[860,869,"SGVLSTSTSF"],[870,879,"GSAPTTSTVF"],[880,889,"SSALSTSTGF"],[890,899,"GGILSTSVCF"],[900,909,"GGSPSSSGSF"],[910,919,"GGTLSTSICF"],[920,929,"GGSPCTSTGF"],[930,939,"GGTLSTSVSF"],[940,949,"GGSSSTSANF"],[950,959,"GGTLSTSICF"],[960,969,"DGSPSTGAGF"],[970,979,"GGALNTSASF"],[980,989,"GSVLNTSTGF"],[990,999,"GGAMSTSADF"],[1000,1009,"GGTLSTSVCF"],[1010,1019,"GGSPGTSVSF"],[1020,1029,"GSALNTNAGY"],[1030,1039,"GGAVSTNTDF"],[1040,1049,"GGTLSTSVCF"],[1050,1059,"GGSPSTSAGF"],[1060,1069,"GGALNTNASF"],[1070,1079,"GCAVSTSASF"],[1080,1089,"SGAVSTSACF"],[1090,1099,"SGAPITNPGF"],[1100,1109,"GGAFSTSAGF"],[1110,1119,"GGALSTAADF"],[1120,1129,"GGTPSNSIGF"],[1130,1139,"GAAPSTSVSF"],[1140,1149,"GGAHGTSLCF"],[1150,1159,"GGAPSTSLCF"],[1160,1169,"GSASNTNLCF"],[1170,1179,"GGPPSTSACF"],[1188,1197,"CDGPSTSTGF"],[1200,1209,"GNGLSTNAGF"],[1210,1219,"GGGLNTSAGF"],[1220,1229,"GGGLGTSAGF"],[1230,1239,"SGGLSTSSGF"],[1240,1249,"DGGLGTSAGF"],[1250,1259,"GGGPGTSTGF"],[1260,1269,"GGGLGTSAGF"],[1270,1279,"SGGLGTSAGF"],[1280,1289,"GGGLVTSDGF"],[1290,1299,"GGGLGTNASF"],[1300,1309,"GSTLGTSAGF"],[1310,1319,"SGGLSTSDGF"],[1328,1337,"DRGLSTIIGF"],[1338,1347,"GSGSNTSTGF"],[1348,1357,"TGEPSTSTGF"],[1358,1367,"SSGPSSIVGF"],[1368,1377,"SGGPSTGVGF"],[1387,1396,"SGGPSTGAGF"],[1397,1406,"GGGPNTGAGF"],[1407,1416,"GGGPSTSAGF"]]},{"c":"[RKQ][PT]KK[AS][KSN]xx+[AKR]","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five dispersed copies in the N-terminal disordered region separated by variable 25-60 aa Ser/Thr/Ala-rich linkers, anchored by a conserved [PT]-K-K-[AS] N-terminal core and a downstream basic pair.","i":[[65,74,"RPKKSKTKKA"],[135,144,"QPKKANKMKR"],[201,210,"KPKKASKAKK"],[253,262,"RTKKASKARK"],[296,305,"RPKKSKGKKA"]]}],"s":"MDRRNDYGYRVPLFQGPLPPPGSLGLPFPPDIQTETTEEDSVLLMHTLLAATKDSLAMDPPVVNRPKKSKTKKAPIKTITKAAPAAPPVPAANEIATNKPKITWQALNLPVITQISQALPTTEVTNTQASSVTAQPKKANKMKRVTAKAAQGSQSPTGHEGGTIQLKSPLQVLKLPVISQNIHAPIANESASSQALITSIKPKKASKAKKAANKAIASATEVSLAATATHTATTQGQITNETASIHTTAASIRTKKASKARKTIAKVINTDTEHIEALNVTDAATRQIEASVVAIRPKKSKGKKAASRGPNSVSEISEAPLATQIVTNQALAATLRVKRGSRARKAATKARATESQTPNADQGAQAKIASAQTNVSALETQVAAAVQALADDYLAQLSLEPTTRTRGKRNRKSKHLNGDERSGSNYRRIPWGRRPAPPRDVAILQERANKLVKYLLVKDQTKIPIKRSDMLRDVIQEYDEYFPEIIERASYTLEKMFRVNLKEIDKQSSLYILISTQESSAGILGTTKDTPKLGLLMVILSVIFMNGNKASEAVIWEVLRKLGLRPGVRHSLFGEVRKLITDEFVKQKYLEYKRVPNSRPPEYEFFWGLRSYHETSKMKVLKFACRVQKKDPKDWAVQYREAVEMEVQAAAVAVAEAEARAEARAQMGIGEEAVAGPWNWDDMDIDCLTREELGDDAQAWSRFSFEIEARAQENADASTNVNFSRGASTRAGFSDGASISFNGAPSSSGGFSGGPGITFGVAPSTSASFSNTASISFGGTLSTSSSFSSAASISFGCAHSTSTSFSSEASISFGGMPCTSASFSGGVSSSFSGPLSTSATFSGGASSGFGGTLSTTAGFSGVLSTSTSFGSAPTTSTVFSSALSTSTGFGGILSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGGTLSTSVSFGGSSSTSANFGGTLSTSICFDGSPSTGAGFGGALNTSASFGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGALNTNASFGCAVSTSASFSGAVSTSACFSGAPITNPGFGGAFSTSAGFGGALSTAADFGGTPSNSIGFGAAPSTSVSFGGAHGTSLCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFCDGPSTSTGFSFGNGLSTNAGFGGGLNTSAGFGGGLGTSAGFSGGLSTSSGFDGGLGTSAGFGGGPGTSTGFGGGLGTSAGFSGGLGTSAGFGGGLVTSDGFGGGLGTNASFGSTLGTSAGFSGGLSTSDGFGSRPNASFDRGLSTIIGFGSGSNTSTGFTGEPSTSTGFSSGPSSIVGFSGGPSTGVGFCSGPSTSGFSGGPSTGAGFGGGPNTGAGFGGGPSTSAGFGSGAASLGACGFSYG"},{"id":"SEQ_02120","a":"A6NFI3","g":"ZNF316","d":"Zinc finger protein 316","L":1004,"m":[{"c":"CxxCG[KRA]xFxxx[SA]x[LF]xxHxxxH[TAR][GAE]x[KRT][PA]xx","u":28,"sp":"tandem","x":"structured_like","cf":"high","why":"Fourteen 28-residue repeats organized into two head-to-tail tandem arrays (5 copies at 347-486 and 9 copies at 693-944), defined by strictly invariant C1, C4, G5, F8, H17, and H21 anchors along with conserved [SA]12, [LF]14, and TGE[KR]P-like linker positions.","i":[[347,374,"CDVCGKVFPHRSRLAKHQRYHAAVKPFG"],[375,402,"CEECGKGFVYRSHLAIHQRTHTGEKPFP"],[403,430,"CPDCGKRFVYKSHLVTHRRIHTGERPYR"],[431,458,"CAFCGAGFGRRSYLVTHQRTHTGERPYP"],[459,486,"CSHCGRSFSQSSALARHQAVHTADRPHC"],[693,720,"CSDCGKTFGRRAALAKHQRYHAGERPHR"],[721,748,"CADCGKSFVYGSHLARHRRTHTGERPFP"],[749,776,"CPECGARFARGSHLAAHVRGHTGEKPFV"],[777,804,"CGVCGAGFSRRAHLTAHGRAHTGERPYA"],[805,832,"CGECGRRFGQSAALTRHQWAHAEEKPHR"],[833,860,"CPDCGKGFGHSSDFKRHRRTHTGEKPFR"],[861,888,"CADCGRGFAQRSNLAKHRRGHTGERPFP"],[889,916,"CPECGKRFSQRSVLVTHQRTHTGERPYA"],[917,944,"CANCGRRFSQSSHLLTHMKTHRGATAAP"]]}],"s":"MAALHTTPDSPAAQLERAEDGSECDPDQEEEEEEEEKGEEVQEVEEEEEEIVVEEEEEGVAEVVQDAQVEAVAEVEVEADVEEEDVKEVLAEEECPALGTQERLSRGGDAKSPVLQEKGLQASRAPATPRDEDLEEEEEEEEDEDEDDLLTAGCQELVTFEDVAVYFSLEEWERLEADQRGLYQEVMQENYGILVSLGYPIPKPDLIFRLEQGEEPWVPDSPRPEEGDIVTGVYTGAWFWTDDIEDHEEEDDEDFLAEVAEEENEPPGLWSAAYGVGDVPGTWGPDDSDSAQTPEGWGPDPGGLGVLADGSEAKPFLPGREPGANLLSPWAFPAAVAPPAGRPETTCDVCGKVFPHRSRLAKHQRYHAAVKPFGCEECGKGFVYRSHLAIHQRTHTGEKPFPCPDCGKRFVYKSHLVTHRRIHTGERPYRCAFCGAGFGRRSYLVTHQRTHTGERPYPCSHCGRSFSQSSALARHQAVHTADRPHCCPDCGQAFRLRADFQRHRRGGGCAEAGGDGPRREPGETAAAAGPEDTDPGPEGSEVGEADGEAEAAAEEREEAAVAAPTPSGKVDPAPERRFLELGNGLGEGEGPSSHPLGFHFPVHPKSWLHPDSFPILGLPDFRERLPVDGRPLPAPLGGPLSLVEGTGLACDPFGGGGAAGGGGGLRAFGPAIGGLLAEPAPAALAEEESPWICSDCGKTFGRRAALAKHQRYHAGERPHRCADCGKSFVYGSHLARHRRTHTGERPFPCPECGARFARGSHLAAHVRGHTGEKPFVCGVCGAGFSRRAHLTAHGRAHTGERPYACGECGRRFGQSAALTRHQWAHAEEKPHRCPDCGKGFGHSSDFKRHRRTHTGEKPFRCADCGRGFAQRSNLAKHRRGHTGERPFPCPECGKRFSQRSVLVTHQRTHTGERPYACANCGRRFSQSSHLLTHMKTHRGATAAPGSGSAPAPAPKPEAAAKGPSSAGPGERGSALLEFAGGTSFGSEHQAAFAGPSGAYREGVL"},{"id":"SEQ_02125","a":"Q96GD3","g":"SCMH1","d":"Polycomb protein SCMH1","L":660,"m":[{"c":"APψ[HR]xF(x){8,9}NxFKψxMKLEAxDx+NxxxxCxATψxxψxGxxψxψxφDGxxxxxDΩWxxφDSx-IxPψGxCxxoGxxLQPP","u":"85-86","sp":"dispersed","x":"structured_like","cf":"high","why":"Two-copy internal duplication of an 85-86 aa structured domain (residues 42-126 and 150-235) sharing ~30 identical anchor residues—including APψ[HR]xF, MKLEAxDx+N, CxATψ, DG, DΩW, DSx-IxPψGxC, and LQPP—with a single 1-residue length difference in an N-terminal loop.","i":[[42,126,"APVHCFKQSYTPPSNEFKISMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDSAEIQPIGNCEKNGGMLQPP"],[150,235,"APIRIFHKEPPSPSHNFFKMGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRFDSRDIFPVGWCSLTGDNLQPP"]]},{"c":"[PG][KG][KQ]RG[RP][KT]P","u":8,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three non-overlapping 8-aa basic-proline motif copies in the central disordered linker (two tandem copies at 270-285 and a third at 306-313), anchored by invariant R4, G5, and P8 positions and two-state choices across all remaining columns.","i":[[270,277,"PGQRGRKP"],[278,285,"GKKRGRTP"],[306,313,"PKKRGPKP"]]}],"s":"MLVCYSVLACEILWDLPCSIMGSPLGHFTWDKYLKETCSVPAPVHCFKQSYTPPSNEFKISMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDSAEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPIRIFHKEPPSPSHNFFKMGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRFDSRDIFPVGWCSLTGDNLQPPGTKVVIPKNPYPASDVNTEKPSIHSSTKTVLEHQPGQRGRKPGKKRGRTPKTLISHPISAPSKTAEPLKFPKKRGPKPGSKRKPRTLLNPPPASPTTSTPEPDTSTVPQDAATIPSSAMQAPTVCIYLNKNGSTGPHLDKKKVQQLPDHFGPARASVVLQQAVQACIDCAYHQKTVFSFLKQGHGGEVISAVFDREQHTLNLPAVNSITYVLRFLEKLCHNLRSDNLFGNQPFTQTHLSLTAIEYSHSHDRYLPGETFVLGNSLARSLEPHSDSMDSASNPTNLVSTSQRHRPLLSSCGLPPSTASAVRRLCSRGVLKGSNERRDMESFWKLNRSPGSDRYLESRDASRLSGRDPSSWTVEDVMQFVREADPQLGPHADLFRKHEIDGKALLLLRSDMMMKYMGLKLGPALKLSYHIDRLKQGKF"},{"id":"SEQ_02127","a":"Q9P1V8","g":"SAMD15","d":"Sterile alpha motif domain-containing protein 15","L":674,"m":[{"c":"[LTP][EQ][PL]P-xx+P-xP--(x){1,3}+[KE]ox-[EK]xx","u":"23-25","sp":"tandem","x":"disordered_like","cf":"high","why":"Eleven copies of a predominantly 24-aa proline/charged disordered repeat (nine consecutive head-to-tail tandem copies across residues 181-396 flanked by two closely spaced boundary copies) anchored by an N-terminal [LTP][EQ][PL]P- motif, internal +P-xP-- positions, and a C-terminal +[KE]ox-[EK]xx segment.","i":[[135,158,"LEPPEEAKPNVTEDVFLESAMETD"],[181,205,"LELLEEETEPGVPEESLRVQHEETG"],[206,229,"LEPPEQTKQDFPSEKLGESLEETD"],[230,253,"LQPPKMTKPETPEETQRESTEKKR"],[254,277,"TEPPEQARLEFLEKEPRKSSEEAG"],[278,301,"LEPPEETQPEVPEEMQRKATEEKG"],[302,325,"TELPERTKPDFPDHKPRKSTDENV"],[326,349,"PEPLEEIKLEFPEEESRKTNEETI"],[350,372,"LEQSEMMKPESPEEIRKSNEKKN"],[373,396,"PQPPEETGPVLPQEINPQVEEKTQ"],[404,427,"LELPDETKPRETHVEFSKEDRPEP"]]}],"s":"MAEVPEDYDSGPDEDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEESIGTHYEFLQPLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDETQPEKGTELQFEHLNWDPEEVAEWISQLGFPQYKECFITNFISGRKLIHVNCSNLPQMGITNFEDMKAISRHTQELLEIEEPLFKRSISLPYRDIIGLYLEQKGHTGIKSDSLTLSEFVKAAGLQDYAPEITAPEENEELPCTEP"},{"id":"SEQ_02132","a":"P62683","g":"ERVK-21","d":"Endogenous retrovirus group K member 21 Gag polyprotein","L":666,"m":[{"c":"PP[VAP][EA]xQY","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three tandem 7-aa repeats separated by single-residue linkers in the central proline/glutamine-rich disordered region, anchored by invariant N-terminal PP and C-terminal QY positions with constrained [VAP][EA] internal positions.","i":[[206,212,"PPVAYQY"],[214,220,"PPAELQY"],[222,228,"PPPESQY"]]},{"c":"xCxxCxxxxHφxxoCx","u":16,"sp":"dispersed","x":"structured_like","cf":"medium","why":"Two duplicated 16-aa zinc-knuckle-like repeats separated by a 20-aa linker, defined by strictly phased invariant C-x2-C-x4-H-x4-C coordination anchors plus conserved hydrophobic (L/W) and polar amide (N/Q) core positions.","i":[[545,560,"KCYNCGQIGHLKKNCP"],[581,596,"LCPRCKKGKHWASQCR"]]}],"s":"MGQTKSKIKSKYASYLSFIKILLKRGGVKVSTKNLIKLFQIIEQFCPWFPEQGTLDLKDWKRIGKELKQAGRKGNIIPLTVWNDWAIIKAALEPFQTEEDSISVSDAPGSCIIDCNENTRKKSQKETEGLHCEYAAEPVMAQSTQNVDYNQLQEVIYPETLKLEGKGPELVGPSESKPRGTSPLPAGQVPVTLQPQTQVKENKTQPPVAYQYWPPAELQYRPPPESQYGYPGMPPAPQGRAPYPQPPTRRLNPTAPPSRQGSELHEIIDKSRKEGDTEAWQFPVMLEPMPPGEGAQEGEPPTVEARYKSFSIKMLKDMKEGVKQYGPNSPYMRTLLDSIAHGHRLIPYDWEILAKSSLLPSQFLQFKTWWIDGVQEQVQRNRAANPPVNIDADQLLGIGQNWSTISQQALMQNEAIEQVRAICLRAWEKIQDPGSTCPSFNTVRQSSKEPYPDFVARLQDVAQKSIADEKARKVIVELMAYENANPECQSAIKPLKGKVPAGSDVISEYVKACDGIGGAMHKAMLMAQAITGVVLGGQVRTFGGKCYNCGQIGHLKKNCPVLNKQNITIQATTTGREPPDLCPRCKKGKHWASQCRSKFDKNGQPLSGNEQRGQPQAPQQTGAFPIQPFVPQGFQGQQPPLSQVFQGISQLPQYNNCPPPQAAVQQ"},{"id":"SEQ_02152","a":"O14867","g":"BACH1","d":"Transcription regulator protein BACH1","L":736,"m":[{"c":"CPφxxxx[SI]","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed copies in disordered regions anchored by an invariant N-terminal CP dipeptide followed immediately by an aromatic/hydrophobic residue (W, F, Y, L), hydrophobic-enriched internal positions, and a C-terminal [LI]S motif (shifted by +1 residue as GIRIS in the first copy).","i":[[435,442,"CPWLGIRI"],[461,468,"CPFISTLS"],[492,499,"CPYACVIS"],[646,653,"CPLSFLIS"]]}],"s":"MSLSENSVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADGELNITLPEEVTVKGFEPLIQFAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFLKFKFLDSTADQQECPRKKCFSSHCQKTDLKLSLLDQRDLETDEVEEFLENKNVQTPQCKLRRYQGNAKASPPLQDSASQTYESMCLEKDAALALPSLCPKYRKFQKAFGTDRVRTGESSVKDIHASVQPNERSENECLGGVPECRDLQVMLKCDESKLAMEPEETKKDPASQCPTEKSEVTPFPHNSSIDPHGLYSLSLLHTYDQYGDLNFAGMQNTTVLTEKPLSGTDVQEKTFGESQDLPLKSDLGTREDSSVASSDRSSVEREVAEHLAKGFWSDICSTDTPCQMQLSPAVAKDGSEQISQKRSECPWLGIRISESPEPGQRTFTTLSSVNCPFISTLSTEGCSSNLEIGNDDYVSEPQQEPCPYACVISLGDDSETDTEGDSESCSAREQECEVKLPFNAQRIISLSRNDFQSLLKMHKLTPEQLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLQSEKESLLKERDHILSTLGETKQNLTGLCQKVCKEAALSQEQIQILAKYSAADCPLSFLISEKDKSTPDGELALPSIFSLSDRPPAVLPPCARGNSEPGYARGQESQQMSTATSEQAGPAEQCRQSGGISDFCQQMTDKCTTDE"},{"id":"SEQ_02156","a":"O43602","g":"DCX","d":"Neuronal migration protein doublecortin","L":365,"m":[{"c":"VxφφRoGx+xxKxψxφφψoxxxφxSF-xψLxDψTxxψ(x){6,9}V+xψYTψDGxxxxxxxDxφx-x-xΩψxxxxxxF+","u":"77-80","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of a ~77-80 aa globular domain separated by a 47-aa linker, sharing conserved N-terminal VxφφRoG, central helical SF-xψLxDψTxxψ, beta-hairpin V+xψYTψDG, acidic/aromatic Dxφx-x-xΩψ, and C-terminal F+ anchors with a single 3-residue loop length difference.","i":[[55,134,"VRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCSSDNFFK"],[182,258,"VTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKKLYTLDGKQVTCLHDFFGDDDVFIACGPEKFR"]]}],"s":"MELDFGHFDERDKTSRNMRGSRMNGLPSPTHSAHCSFYRTRTLQALSNEKKAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCSSDNFFKKVEYTKNVNPNWSVNVKTSANMKAPQSLASSNSAQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKKLYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKGNPSATAGPKASPTPQKTSAKSPGPMRRSKSPADSGNDQDANGTSSSQLSTPKSKQSPISTPTSPGSLRKHKDLYLPLSLDDSDSLGDSM"},{"id":"SEQ_02173","a":"P32927","g":"CSF2RB","d":"Cytokine receptor common subunit beta","L":897,"m":[{"c":"FEψxY++xxx[ST]WxD(x){18,19}PS[ST]xYφARVRxR(x){12,13}WSxxxxWD","u":"64-66","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication in the N-terminal structured region sharing three strongly conserved anchor blocks (FEψxY++xxx[ST]WxD, PS[ST]xYφARVRxR, and WSxxxxWD; 17 identical residues overall) separated by two loops with 1-residue length variation.","i":[[171,236,"FEVVYKRLQDSWEDAAILLSNTSQATLGPEHLMPSSTYVARVRTRLAPGSRLSGRPSKWSPEVCWD"],[372,435,"FEIQYRKDTATWKDSKTETLQNAHSMALPALEPSTRYWARVRVRTSRTGYNGIWSEWSEARSWD"]]},{"c":"[DEG]Y[LVC]xLP[PAG]","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed copies in the proline/serine-rich C-terminal disordered tail anchored by invariant Y (+2), L (+5), and P (+6) positions flanked by acidic/glycine ([DEG]) and small/turn ([PAG]) residues.","i":[[627,633,"EYLCLPA"],[765,771,"GYVELPP"],[821,827,"DYCFLPG"],[881,887,"DYLSLPP"]]}],"s":"MVLAQGLLSMALLALCWERSLAGAEETIPLQTLRCYNDYTSHITCRWADTQDAQRLVNVTLIRRVNEDLLEPVSCDLSDDMPWSACPHPRCVPRRCVIPCQSFVVTDVDYFSFQPDRPLGTRLTVTLTQHVQPPEPRDLQISTDQDHFLLTWSVALGSPQSHWLSPGDLEFEVVYKRLQDSWEDAAILLSNTSQATLGPEHLMPSSTYVARVRTRLAPGSRLSGRPSKWSPEVCWDSQPGDEAQPQNLECFFDGAAVLSCSWEVRKEVASSVSFGLFYKPSPDAGEEECSPVLREGLGSLHTRHHCQIPVPDPATHGQYIVSVQPRRAEKHIKSSVNIQMAPPSLNVTKDGDSYSLRWETMKMRYEHIDHTFEIQYRKDTATWKDSKTETLQNAHSMALPALEPSTRYWARVRVRTSRTGYNGIWSEWSEARSWDTESVLPMWVLALIVIFLTIAVLLALRFCGIYGYRLRRKWEEKIPNPSKSHLFQNGSAELWPPGSMSAFTSGSPPHQGPWGSRFPELEGVFPVGFGDSEVSPLTIEDPKHVCDPPSGPDTTPAASDLPTEQPPSPQPGPPAASHTPEKQASSFDFNGPYLGPPHSRSLPDILGQPEPPQEGGSQKSPPPGSLEYLCLPAGGQVQLVPLAQAMGPGQAVEVERRPSQGAAGSPSLESGGGPAPPALGPRVGGQDQKDSPVAIPMSSGDTEDPGVASGYVSSADLVFTPNSGASSVSLVPSLGLPSDQTPSLCPGLASGPPGAPGPVKSGFEGYVELPPIEGRSPRSPRNNPVPPEAKSPVLNPGERPADVSPTSPQPEGLLVLQQVGDYCFLPGLGPGPLSLRSKPSSPGPGPEIKNLDQAFQVKKPPGQAVPQVPVIQLFKALKQQDYLSLPPWEVNKPGEVC"},{"id":"SEQ_02180","a":"O60885","g":"BRD4","d":"Bromodomain-containing protein 4","L":1362,"m":[{"c":"QLxxxxxψψxxxφφK(x){2,4}[FY]AWPFxxPVD[AV]xxLxLxDYxxIIKxPMDM[GS]TIKx+LExxxYxxAQExxxDφxxMF[TS]NCYxYNxPxx-ψVφMAxxLxxψFxx+φxxψPxExxE","u":"109-111","sp":"dispersed","x":"structured_like","cf":"high","why":"Two highly conserved ~110-residue globular domain copies separated by a 182-aa proline-rich linker, sharing 37 identical anchor positions (including [FY]AWPF, PVD, IIKxPMDM[GS]TIK, AQExxxD, MF[TS]NCYxYNxP, and MAxxLxxψF) and a 2-residue loop variation near the N-terminus.","i":[[62,170,"QLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETE"],[353,463,"QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEE"]]}],"s":"MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESIKAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMGSWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSMLDQQRELARKREQERRRREAMAATIDMNFQSDLLSIFEENLF"},{"id":"SEQ_02185","a":"O75970","g":"MPDZ","d":"Multiple PDZ domain protein","L":2070,"m":[{"c":"xφEψx+(x){3,8}[GS]LGφ[ST]ψxG(x){3,15}xφφψxxψxxxx[AVI]AxxDG+φxxGDx[IL]ψx[VI][ND][GDE]xxxxxx(x){0,1}[TS]xxxφxxφL+xxx(x){0,3}xx[VI]xφxφxx","u":"79-91","sp":"dispersed","x":"structured_like","cf":"high","why":"Thirteen 79-91 aa structured repeat units dispersed across the protein with variable linkers (14-220 aa), anchored by conserved [GS]LGφ[ST]ψxG, DG+φxxGDx[IL]ψx[VI][ND], and C-terminal φxxφL+ and [VI]xφxφ hydrophobic core motifs.","i":[[137,222,"VFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIAR"],[257,335,"TIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIAR"],[377,461,"DVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR"],[550,632,"EIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCR"],[700,785,"HIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAK"],[1008,1090,"TINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLRRHSLIGPDIKITYVP"],[1151,1241,"RVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQS"],[1350,1431,"MIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIR"],[1483,1562,"HLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHA"],[1629,1710,"TIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYR"],[1725,1805,"TIELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKCSLGTVTLEVGR"],[1862,1946,"TVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVA"],[1987,2070,"SITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVLS"]]}],"s":"MLEAIDKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKDQVNIATSATSNIEYAHVPHLSPAVIPTLQNESFLLSPNNGNLEALTGPGIPHINGKPACDEFDQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGLADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQASILSLHGSSCGDGLNYGSSLPSSPPKDVIENSCDPVLDLHMSLEELYTQNLLQRQDENTPSVDISMGPASGFTINDYTPANAIEQQYECENTIVWTESHLPSEVISSAELPSVLPDSAGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKCSLGTVTLEVGRIKAGPFHSERRPSQSSQVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVLS"},{"id":"SEQ_02202","a":"Q9NYJ8","g":"TAB2","d":"TGF-beta-activated kinase 1 and MAP3K7-binding protein 2","L":693,"m":[{"c":"R[NS]QP[TK][VL][YF]I[AS][AT][NS](x){7,9}M","u":"19-21","sp":"tandem","x":"disordered_like","cf":"high","why":"Three tandem 19-21 aa repeats (separated by 1 and 0 residues) within the central S/T/P/Q/N-rich disordered region, anchored by a strongly conserved N-terminal R[NS]QP[TK][VL][YF]I[AS][AT][NS] core and a C-terminal M boundary (with DE..M shared in the first two copies).","i":[[362,380,"RNQPTVYIAASPPNTDELM"],[382,401,"RSQPKVYISANAATGDEQVM"],[402,422,"RNQPTLFISTNSGASAASRNM"]]}],"s":"MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSELFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVTLAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFNPMNPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQPPTIHSSGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTLNRNQPTVYIAASPPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASRNMSGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDTEDDEGAQWNCTACTFLNHPALIRCEQCEMPRHF"},{"id":"SEQ_02214","a":"Q9UPW8","g":"UNC13A","d":"Protein unc-13 homolog A","L":1703,"m":[{"c":"YVTψ[KQ]V(x){14,15}PxWE[QE][DN]FxFExxxxxxxψxVxVW[ND]","u":"44-45","sp":"dispersed","x":"structured_like","cf":"high","why":"Two dispersed 44-45 aa structured-like domain cores (positions 23-66 and 700-744) share 13 identical anchor residues in register—including YVTψ[KQ]V, PxWE[QE][DN]FxFE, and ψxVxVW[ND]—flanking a 14-15 aa variable loop.","i":[[23,66,"YVTLKVQNVKSTTIAVRGSQPSWEQDFMFEINRLDLGLTVEVWN"],[700,744,"YVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVWD"]]}],"s":"MSLLCVGVKKAKFDGAQEKFNTYVTLKVQNVKSTTIAVRGSQPSWEQDFMFEINRLDLGLTVEVWNKGLIWDTMVGTVWIPLRTIRQSNEEGPGEWLTLDSQVIMADSEICGTKDPTFHRILLDTRFELPLDIPEEEARYWAKKLEQLNAMRDQDEYSFQDEQDKPLPVPSNQCCNWNYFGWGEQHNDDPDSAVDDRDSDYRSETSNSIPPPYYTTSQPNASVHQYSVRPPPLGSRESYSDSMHSYEEFSEPQALSPTGSSRYASSGELSQGSSQLSEDFDPDEHSLQGSDMEDERDRDSYHSCHSSVSYHKDSPRWDQDEEELEEDLEDFLEEEELPEDEEELEEEEEEVPDDLGSYAQREDVAVAEPKDFKRISLPPAAPGKEDKAPVAPTEAPDMAKVAPKPATPDKVPAAEQIPEAEPPKDEESFRPREDEEGQEGQDSMSRAKANWLRAFNKVRMQLQEARGEGEMSKSLWFKGGPGGGLIIIDSMPDIRKRKPIPLVSDLAMSLVQSRKAGITSALASSTLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDRTQNIIMVLKDRMKIRERNKPEIFELIQEIFAVTKTAHTQQMKAVKQSVLDGTSKWSAKISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAMRYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSMYRNNFPASSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHELYSREYQTDPAKKGEVLPEEQGPSIKNLDFWSKLITLIVSIIEEDKNSYTPCLNQFPQELNVGKISAEVMWNLFAQDMKYAMEEHDKHRLCKSADYMNLHFKVKWLYNEYVTELPAFKDRVPEYPAWFEPFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSEHALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISNVLLQYADIISKDFASYCSKEKEKVPCILMNNTQQLRVQLEKMFEAMGGKELDAEASDILKELQVKLNNVLDELSRVFATSFQPHIEECVKQMGDILSQVKGTGNVPASACSSVAQDADNVLQPIMDLLDSNLTLFAKICEKTVLKRVLKELWKLVMNTMEKTIVLPPLTDQTMIGNLLRKHGKGLEKGRVKLPSHSDGTQMIFNAAKELGQLSKLKDHMVREEAKSLTPKQCAVVELALDTIKQYFHAGGVGLKKTFLEKSPDLQSLRYALSLYTQATDLLIKTFVQTQSAQGLGVEDPVGEVSVHVELFTHPGTGEHKVTVKVVAANDLKWQTSGIFRPFIEVNIIGPQLSDKKRKFATKSKNNSWAPKYNESFQFTLSADAGPECYELQVCVKDYCFAREDRTVGLAVLQLRELAQRGSAACWLPLGRRIHMDDTGLTVLRILSQRSNDEVAKEFVKLKSDTRSAEEGGAAPAP"},{"id":"SEQ_02216","a":"Q14185","g":"DOCK1","d":"Dedicator of cytokinesis protein 1","L":1865,"m":[{"c":"[TVL]PPP[PLV][PT][PLS][KRH]","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five 8-residue proline-rich motifs clustered in the C-terminal disordered tail (residues 1767-1851), each anchored by an N-terminal [TVL] residue and a C-terminal basic [KRH] residue flanking a conserved PPP[PLV][PT][PLS] core (with four copies strictly preserving the PPPxPx[KH] register).","i":[[1767,1774,"TPPPVTPR"],[1798,1805,"VPPPLPLK"],[1825,1832,"TPPPPPPH"],[1836,1843,"LPPPLPSK"],[1844,1851,"TPPPPPPK"]]}],"s":"MTRWVPTKREEKYGVAFYNYDARGADELSLQIGDTVHILETYEGWYRGYTLRKKSKKGIFPASYIHLKEAIVEGKGQHETVIPGDLPLIQEVTTTLREWSTIWRQLYVQDNREMFRSVRHMIYDLIEWRSQILSGTLPQDELKELKKKVTAKIDYGNRILDLDLVVRDEDGNILDPELTSTISLFRAHEIASKQVEERLQEEKSQKQNIDINRQAKFAATPSLALFVNLKNVVCKIGEDAEVLMSLYDPVESKFISENYLVRWSSSGLPKDIDRLHNLRAVFTDLGSKDLKREKISFVCQIVRVGRMELRDNNTRKLTSGLRRPFGVAVMDVTDIINGKVDDEDKQHFIPFQPVAGENDFLQTVINKVIAAKEVNHKGQGLWVTLKLLPGDIHQIRKEFPHLVDRTTAVARKTGFPEIIMPGDVRNDIYVTLVQGDFDKGSKTTAKNVEVTVSVYDEDGKRLEHVIFPGAGDEAISEYKSVIYYQVKQPRWFETVKVAIPIEDVNRSHLRFTFRHRSSQDSKDKSEKIFALAFVKLMRYDGTTLRDGEHDLIVYKAEAKKLEDAATYLSLPSTKAELEEKGHSATGKSMQSLGSCTISKDSFQISTLVCSTKLTQNVDLLGLLKWRSNTSLLQQNLRQLMKVDGGEVVKFLQDTLDALFNIMMENSESETFDTLVFDALVFIIGLIADRKFQHFNPVLETYIKKHFSATLAYTKLTKVLKNYVDGAEKPGVNEQLYKAMKALESIFKFIVRSRILFNQLYENKGEADFVESLLQLFRSINDMMSSMSDQTVRVKGAALKYLPTIVNDVKLVFDPKELSKMFTEFILNVPMGLLTIQKLYCLIEIVHSDLFTQHDCREILLPMMTDQLKYHLERQEDLEACCQLLSHILEVLYRKDVGPTQRHVQIIMEKLLRTVNRTVISMGRDSELIGNFVACMTAILRQMEDYHYAHLIKTFGKMRTDVVDFLMETFIMFKNLIGKNVYPFDWVIMNMVQNKVFLRAINQYADMLNKKFLDQANFELQLWNNYFHLAVAFLTQESLQLENFSSAKRAKILNKYGDMRRQIGFEIRDMWYNLGQHKIKFIPEMVGPILEMTLIPETELRKATIPIFFDMMQCEFHSTRSFQMFENEIITKLDHEVEGGRGDEQYKVLFDKILLEHCRKHKYLAKTGETFVKLVVRLMERLLDYRTIMHDENKENRMSCTVNVLNFYKEIEREEMYIRYLYKLCDLHKECDNYTEAAYTLLLHAKLLKWSEDVCVAHLTQRDGYQATTQGQLKEQLYQEIIHYFDKGKMWEEAIALGKELAEQYENEMFDYEQLSELLKKQAQFYENIVKVIRPKPDYFAVGYYGQGFPTFLRGKVFIYRGKEYERREDFEARLLTQFPNAEKMKTTSPPGDDIKNSPGQYIQCFTVKPKLDLPPKFHRPVSEQIVSFYRVNEVQRFEYSRPIRKGEKNPDNEFANMWIERTIYTTAYKLPGILRWFEVKSVFMVEISPLENAIETMQLTNDKINSMVQQHLDDPSLPINPLSMLLNGIVDPAVMGGFANYEKAFFTDRYLQEHPEAHEKIEKLKDLIAWQIPFLAEGIRIHGDKVTEALRPFHERMEACFKQLKEKVEKEYGVRIMPSSLDDRRGSRPRSMVRSFTMPSSSRPLSVASVSSLSSDSTPSRPGSDGFALEPLLPKKMHSRSQDKLDKDDLEKEKKDKKKEKRNSKHQEIFEKEFKPTDISLQQSEAVILSETISPLRPQRPKSQVMNVIGSERRFSVSPSSPSSQQTPPPVTPRAKLSFSMQSSLELNGMTGADVADVPPPLPLKGSVADYGNLMENQDLLGSPTPPPPPPHQRHLPPPLPSKTPPPPPPKTTRKQASVDSGIVQ"},{"id":"SEQ_02226","a":"Q9UQD0","g":"SCN8A","d":"Sodium channel protein type 8 subunit alpha","L":1980,"m":[{"c":"φφIxxx[IL]xx[NS]xφ[FLT][MA](x){13,20}x[TV]F[TV]x[IF][YF][TI]xExφ[VL]KφxAx(x){3,8}[FY][FL]xx[PGA]W[NC][WI][LF]D[FG]x[VI][IV]xψ[AS]φψxxxφ(x){8,17}RxφRφ[LG]Rx[LF]+xφ[SK]xφ[PEK][GT]ψ[KNR][TMV]ψψx[AI][LI]xx[SA]ψ[PGK][ASK][LI]x[ND]ψx[LI][LV][LCT]φφxφ[FLS][IV]F[AS]ψφGψo[LN]F(x){56,114}φ[IF]φF[VM]xφ[IM]φφ[GS][SNF][FL]φ[VLT][VL]N[LM]φ[LI][AG]ψψφx[NAS][FY]","u":"224-279","sp":"dispersed","x":"structured_like","cf":"high","why":"Four large homologous multi-helix domain repeats (224-279 aa) separated by variable linkers (58-342 aa), sharing five ungapped hydrophobic core blocks anchored by invariant residues (I in block 1; F, E, K, A in block 2; W, D in block 3; periodic RxxRxxRxx+ motif and FxxxGxxF in block 4; F and N in block 5) with variable inter-helical loops.","i":[[136,414,"MIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAY"],[757,980,"LAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSF"],[1203,1467,"FIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNF"],[1526,1769,"IVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENF"]]}],"s":"MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHIGGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLENGGTHREKKESTPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESKC"},{"id":"SEQ_02228","a":"Q5VUJ6","g":"LRCH2","d":"Leucine-rich repeat and calponin homology domain-containing protein 2","L":765,"m":[{"c":"Lxx[LI]xφxxNxψxxxPxxφ(x){4,5}","u":"22-23","sp":"tandem","x":"structured_like","cf":"high","why":"Seven head-to-tail tandem 22-23 aa repeats in a structured region anchored by invariant L1, N9, and P15 residues alongside conserved aliphatic/hydrophobic positions ([LI]4, φ6, ψ11, φ18, and a C-terminal L).","i":[[136,158,"LETLNLYHNCIKTIPEAIKNLQM"],[159,180,"LTYLNISRNLLSTLPKYLFDLP"],[181,203,"LKVLVVSNNKLVSIPEEIGKLKD"],[204,226,"LMELDISCNEIQVLPQQMGKLHS"],[227,248,"LRELNIRRNNLHVLPDELGDLP"],[249,271,"LVKLDFSCNKVTEIPVCYRKLHH"],[272,293,"LQVIILDNNPLQVPPAQICLKG"]]}],"s":"MAASQGGGGNSGGGGCGGGGSSGGCGTAGGGGGGAGGGGGGGGGTLVVPIPVPTLFGQPFPNGPPWNPGSLQPQHTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPDSLDLPSLSKRMPSQPLTDSMEDFYPNKNHGPDSGIGSDNGEKRLSTTEPSDDDTVSLHSQVSESNREQTSRNDSHIIGSKTDSQKDQEVYDFVDPNTEDVAVPEQGNAHIGSFVSFFKGKEKCSEKSRKNEELGDEKRLEKEQLLAEEEDDDLKEVTDLRKIAAQLLQQEQKNRILNHSTSVMRNKPKQTVECEKSVSADEVNSPLSPLTWQPLENQKDQIDEQPWPESHPIIWQSEERRRSKQIRKEYFKYKSMRKSSSGNENDEQDSDNANMSTQSPVSSEEYDRTDGFSHSPFGLKPRSAFSRSSRQEYGAADPGFTMRRKMEHLREEREQIRQLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKLGVSQERLCLPHHILEERGLVKVGVTVQALLELPTTKASQLSVA"},{"id":"SEQ_02233","a":"Q14839","g":"CHD4","d":"ATP-dependent chromatin remodeler CHD4","L":1912,"m":[{"c":"-ΩCxVCxxGGEψψxCDTCPxxYHψxCL[DN]PxψxxφPxGxWxCP[HR]C","u":44,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two highly conserved 44-aa cysteine/histidine-rich structured repeats separated by a 35-aa acidic linker, sharing 23 identical anchor positions (including CxVC, GGE, CDTCP, YH, CL, P, G, W, and CPxC) plus conserved aromatic and aliphatic positions.","i":[[371,414,"DYCEVCQQGGEIILCDTCPRAYHMVCLDPDMEKAPEGKWSCPHC"],[450,493,"EFCRVCKDGGELLCCDTCPSSYHIHCLNPPLPEIPNGEWLCPRC"]]}],"s":"MASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPENEEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKERMLLCRQLGDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSEEDYRTLTNYKAFSQFVRPLIAAKNPKIAVSKMMMVLGAKWREFSTNNPFKGSSGASVAAAAAAAVAVVESMVTATEVAPPPPPVEVPIRKAKTKEGKGPNARRKPKGSPRVPDAKKPKPKKVAPLKIKLGGFGSKRKRSSSEDDDLDVESDFDDASINSYSVSDGSTSRSSRSRKKLRTTKKKKKGEEEVTAVDGYETDHQDYCEVCQQGGEIILCDTCPRAYHMVCLDPDMEKAPEGKWSCPHCEKEGIQWEAKEDNSEGEEILEEVGGDLEEEDDHHMEFCRVCKDGGELLCCDTCPSSYHIHCLNPPLPEIPNGEWLCPRCTCPALKGKVQKILIWKWGQPPSPTPVPRPPDADPNTPSPKPLEGRPERQFFVKWQGMSYWHCSWVSELQLELHCQVMFRNYQRKNDMDEPPSGDFGGDEEKSRKRKNKDPKFAEMEERFYRYGIKPEWMMIHRILNHSVDKKGHVHYLIKWRDLPYDQASWESEDVEIQDYDLFKQSYWNHRELMRGEEGRPGKKLKKVKLRKLERPPETPTVDPTVKYERQPEYLDATGGTLHPYQMEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVTYVGDKDSRAIIRENEFSFEDNAIRGGKKASRMKKEASVKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHMLRRLKADVFKNMPSKTELIVRVELSPMQKKYYKYILTRNFEALNARGGGNQVSLLNVVMDLKKCCNHPYLFPVAAMEAPKMPNGMYDGSALIRASGKLLLLQKMLKNLKEGGHRVLIFSQMTKMLDLLEDFLEHEGYKYERIDGGITGNMRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKKKMMLTHLVVRPGLGSKTGSMSKQELDDILKFGTEELFKDEATDGGGDNKEGEDSSVIHYDDKAIERLLDRNQDETEDTELQGMNEYLSSFKVAQYVVREEEMGEEEEVEREIIKQEESVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDGSQEDRDWQDDQSDNQSDYSVASEEGDEDFDERSEAPRRPSRKGLRNDKDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRYGMPPQDAFTTQWLVRDLRGKSEKEFKAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHVNGRWSMPELAEVEENKKMSQPGSPSPKTPTPSTPGDTQPNTPAPVPPAEDGIKIEENSLKEEESIEGEKEVKSTAPETAIECTQAPAPASEDEKVVVEPPEGEEKVEKAEVKERTEEPMETEPKGAADVEKVEEKSAIDLTPIVVEDKEEKKEEEEKKEVMLQNGETPKDLNDEKQKKNIKQRFMFNIADGGFTELHSLWQNEERAATVTKKTYEIWHRRHDYWLLAGIINHGYARWQDIQNDPRYAILNEPFKGEMNRGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQLEELLSDMKADVTRLPATIARIPPVAVRLQMSERNILSRLANRAPEPTPQQVAQQQ"},{"id":"SEQ_02242","a":"P02462","g":"COL4A1","d":"Collagen alpha-1(IV) chain","L":1669,"m":[{"c":"[GA]φψψ[AT]xHSQTIxxP[PQ]CPSGxxxLΩxGYSφψφ(x){8,9}GQxL[GA][ST][AP]GSCLxxFx[ST]φPFψxCxxxxxCNΩ(x){4,5}YSΩWL[AS]T(x){12,17}GE(x){4,5}ψSRCxVC","u":"107-111","sp":"tandem","x":"structured_like","cf":"high","why":"Two tandem ~110-aa cysteine-rich globular repeats at the C-terminus following a long collagenous G-x-y region, sharing six strictly conserved cysteines and conserved sequence blocks including HSQTI, P[PQ]CPSG, GYSφψφ, GSCL, PFψxC, CNΩ, YSΩWL[AS]T, and ψSRCxVC.","i":[[1445,1551,"GFLVTRHSQTIDDPQCPSGTKILYHGYSLLYVQGNERAHGQDLGTAGSCLRKFSTMPFLFCNINNVCNFASRNDYSYWLSTPEPMPMSMAPITGENIRPFISRCAVC"],[1555,1665,"AMVMAVHSQTIQIPPCPSGWSSLWIGYSFVMHTSAGAEGSGQALASPGSCLEEFRSAPFIECHGRGTCNYYANAYSFWLATIERSEMFKKPTPSTLKAGELRTHVSRCQVC"]]}],"s":"MGPRLSVWLLLLPAALLLHEEHSRAAAKGGCAGSGCGKCDCHGVKGQKGERGLPGLQGVIGFPGMQGPEGPQGPPGQKGDTGEPGLPGTKGTRGPPGASGYPGNPGLPGIPGQDGPPGPPGIPGCNGTKGERGPLGPPGLPGFAGNPGPPGLPGMKGDPGEILGHVPGMLLKGERGFPGIPGTPGPPGLPGLQGPVGPPGFTGPPGPPGPPGPPGEKGQMGLSFQGPKGDKGDQGVSGPPGVPGQAQVQEKGDFATKGEKGQKGEPGFQGMPGVGEKGEPGKPGPRGKPGKDGDKGEKGSPGFPGEPGYPGLIGRQGPQGEKGEAGPPGPPGIVIGTGPLGEKGERGYPGTPGPRGEPGPKGFPGLPGQPGPPGLPVPGQAGAPGFPGERGEKGDRGFPGTSLPGPSGRDGLPGPPGSPGPPGQPGYTNGIVECQPGPPGDQGPPGIPGQPGFIGEIGEKGQKGESCLICDIDGYRGPPGPQGPPGEIGFPGQPGAKGDRGLPGRDGVAGVPGPQGTPGLIGQPGAKGEPGEFYFDLRLKGDKGDPGFPGQPGMPGRAGSPGRDGHPGLPGPKGSPGSVGLKGERGPPGGVGFPGSRGDTGPPGPPGYGPAGPIGDKGQAGFPGGPGSPGLPGPKGEPGKIVPLPGPPGAEGLPGSPGFPGPQGDRGFPGTPGRPGLPGEKGAVGQPGIGFPGPPGPKGVDGLPGDMGPPGTPGRPGFNGLPGNPGVQGQKGEPGVGLPGLKGLPGLPGIPGTPGEKGSIGVPGVPGEHGAIGPPGLQGIRGEPGPPGLPGSVGSPGVPGIGPPGARGPPGGQGPPGLSGPPGIKGEKGFPGFPGLDMPGPKGDKGAQGLPGITGQSGLPGLPGQQGAPGIPGFPGSKGEMGVMGTPGQPGSPGPVGAPGLPGEKGDHGFPGSSGPRGDPGLKGDKGDVGLPGKPGSMDKVDMGSMKGQKGDQGEKGQIGPIGEKGSRGDPGTPGVPGKDGQAGQPGQPGPKGDPGISGTPGAPGLPGPKGSVGGMGLPGTPGEKGVPGIPGPQGSPGLPGDKGAKGEKGQAGPPGIGIPGLRGEKGDQGIAGFPGSPGEKGEKGSIGIPGMPGSPGLKGSPGSVGYPGSPGLPGEKGDKGLPGLDGIPGVKGEAGLPGTPGPTGPAGQKGEPGSDGIPGSAGEKGEPGLPGRGFPGFPGAKGDKGSKGEVGFPGLAGSPGIPGSKGEQGFMGPPGPQGQPGLPGSPGHATEGPKGDRGPQGQPGLPGLPGPMGPPGLPGIDGVKGDKGNPGWPGAPGVPGPKGDPGFQGMPGIGGSPGITGSKGDMGPPGVPGFQGPKGLPGLQGIKGDQGDQGVPGAKGLPGPPGPPGPYDIIKGEPGLPGPEGPPGLKGLQGLPGPKGQQGVTGLVGIPGPPGIPGFDGAPGQKGEMGPAGPTGPRGFPGPPGPDGLPGSMGPPGTPSVDHGFLVTRHSQTIDDPQCPSGTKILYHGYSLLYVQGNERAHGQDLGTAGSCLRKFSTMPFLFCNINNVCNFASRNDYSYWLSTPEPMPMSMAPITGENIRPFISRCAVCEAPAMVMAVHSQTIQIPPCPSGWSSLWIGYSFVMHTSAGAEGSGQALASPGSCLEEFRSAPFIECHGRGTCNYYANAYSFWLATIERSEMFKKPTPSTLKAGELRTHVSRCQVCMRRT"},{"id":"SEQ_02246","a":"Q8N660","g":"NBPF15","d":"NBPF family member NBPF15","L":670,"m":[{"c":"PRxxxxx(x){3,6}EV[LP][QE]-S[LW]-[RE][CG][YA][SI]T[PCL]Sxxx[EG]xx[DA][SL]xQ[PSH][YH]x[SK]xxxx[LF]E[EQ]xxψxx[AST]ψ","u":"53-56","sp":"dispersed","x":"structured_like","cf":"high","why":"Six copies of a strongly conserved 53-56 aa domain repeat in the C-terminal two-thirds, anchored by invariant PR, EV, S, T, S, Q, and E positions plus conserved acidic (-) and hydrophobic/aliphatic ([LW], [LF], ψ) core positions, with a 3-aa length difference in an N-terminal acidic loop and 22-45 aa charged linkers.","i":[[188,240,"PREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHKKTKITFEEDKVDSTL"],[274,326,"PRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAV"],[346,401,"PRLSRELLDEKEPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAI"],[421,476,"PRLSRELLDEKEPEVLQDSLDRCYSTPSDYLELPDLGQPYSSAVYSLEEQYLGLAL"],[496,551,"PRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSL"],[589,644,"PRLYGVLMEVEEPEVLQDSLDRCYSTPSMYFEQPDSFQHYRSVFYSFEEEHISFAL"]]}],"s":"MVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRNLKEKCFLTQLAGFLANRQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLTQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHKKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKEPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAIDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSDYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKKRRRGRKEGEDDNPPCPRLYGVLMEVEEPEVLQDSLDRCYSTPSMYFEQPDSFQHYRSVFYSFEEEHISFALYVDNRFFTLTVTSLHLVFQMGVIFPQ"},{"id":"SEQ_02254","a":"Q14028","g":"CNGB1","d":"Cyclic nucleotide-gated channel beta-1","L":1251,"m":[{"c":"RψψxWψxxxψExφψPQP[PV]","u":18,"sp":"dispersed","x":"mixed","cf":"high","why":"Three dispersed 18-aa repeats in the disordered P/E-rich N-terminal region share invariant R1, W5, E11, and P15-Q16-P17 anchors alongside six conserved aliphatic/hydrophobic positions (a truncated N-terminal remnant MLGWVQRVLPQPP also occurs at residues 1-13).","i":[[101,118,"RVLTWLMKGVEKVIPQPV"],[157,174,"RLLLWLEQNLERVLPQPP"],[254,271,"RLVAWVLHRLEMALPQPV"]]}],"s":"MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFKEEEVAVADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHSITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVWRDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQAQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQVEPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEEEEEEEEEEEEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKEAEEKAKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLMAEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSDPTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKPSPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRSNNKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELAALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSPPPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE"},{"id":"SEQ_02259","a":"Q15050","g":"RRS1","d":"Ribosome biogenesis regulatory protein homolog","L":365,"m":[{"c":"[KG]GKRKGG","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four strongly conserved 7-residue copies in the C-terminal disordered tail share an invariant GKRKGG core (diglycine-flanked tribasic KRK motif, with a fifth degenerate GGKRRK variant capping the C-terminus) separated by short variable P/G/Q-rich linkers of 4-12 aa.","i":[[309,315,"KGKRKGG"],[320,326,"GGKRKGG"],[331,337,"GGKRKGG"],[350,356,"GGKRKGG"]]}],"s":"MEGQSVEELLAKAEQDEAEKLQRITVHKELELQFDLGNLLASDRNPPTGLRCAGPTPEAELQALARDNTQLLINQLWQLPTERVEEAIVARLPEPTTRLPREKPLPRPRPLTRWQQFARLKGIRPKKKTNLVWDEVSGQWRRRWGYQRARDDTKEWLIEVPGNADPLEDQFAKRIQAKKERVAKNELNRLRNLARAHKMQLPSAAGLHPTGHQSKEELGRAMQVAKVSTASVGRFQERLPKEKVPRGSGKKRKFQPLFGDFAAEKKNQLELLRVMNSKKPQLDVTRATNKQMREEDQEEAAKRRKMSQKGKRKGGRQGPGGKRKGGPPSQGGKRKGGLGGKMNSGPPGLGGKRKGGQRPGGKRRK"},{"id":"SEQ_02270","a":"Q92610","g":"ZNF592","d":"Zinc finger protein 592","L":1267,"m":[{"c":"φ(x){1,2}CxxC(x){11,15}H(x){3,6}H","u":"23-27","sp":"dispersed","x":"structured_like","cf":"high","why":"Twelve dispersed 23-27 aa repeats across the C-terminal half share an N-terminal hydrophobic/aromatic residue followed by an invariant CxxC pair, an 11-15 aa central segment typically carrying a hydrophobic residue 3 positions before the first H, and a C-terminal H(x){3,6}H pair.","i":[[587,612,"YCCLECGDAFALEKSLSQHYGRRSVH"],[615,639,"VLCTLCSKTLLFFNKCSLLRHARDH"],[740,762,"LTCQVCQMLLPNQCSFCAHQRIH"],[768,792,"YCCPECGVLCRSAYFQTHVKENCLH"],[799,822,"YRCIHCGVVHLTLALLKSHIQERH"],[826,850,"FHKCAFCPMAFKTASSTADHSATQH"],[892,915,"FKCPECPLLFVQKPELMQHVKSTH"],[983,1006,"WTCQECQEWVPDRESYVSHMKKSH"],[1013,1036,"YPCRQCEQSFHTPNSLRKHIRNNH"],[1043,1069,"YTCGYCTEDSPSFPRPSLLESHISLMH"],[1124,1146,"FQCAKCSFATDSGLEFQSHIPQH"],[1153,1176,"AQCLLCGLCYTSASSLSRHLFIVH"]]}],"s":"MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKPPGICMDESVSLSHSGSAPDVPAVSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLPPDPHNCGKFDSTFMNGDSARSFPGKLEPPKSEPLPTFNQFSPISSPEPEDPIKDNGFGIKPKHSDSYFPPPLGCGAVGGPVLEALAKFPVPELHMFDHFCKKEPKPEPLPLGSQQEHEQSGQNTVEPHKDPDATRFFGEALEFNSHPSNSIGESKGLARELGTCSSVPPRQRLKPAHSKLSSCVAALVALQAKRVASVTKEDQPGHTKDLSGPTKESSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKGSPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPVGSPLGSAIAEAPSEMPGDEVPVEEHFPEAGTNSGSPQGARKGDESMTKASDSSSPSCSSGPRVPKGAAPGSQTGKKQQSTALQASTLAPANLLPKAVHLANLNLVPHSVAASVTAKSSVQRRSQPQLTQMSVPLVHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGYCCLECGDAFALEKSLSQHYGRRSVHIEVLCTLCSKTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQMFVSAPVNSTAPAAPAPSSSPKHGLTSGSASPPPPALPLYPDPVRLIRYSIKCLECHKQMRDYMVLAAHFQRTTEETEGLTCQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGVLCRSAYFQTHVKENCLHYARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTASSTADHSATQHPTQPHRPSQLIYKCSCEMVFNKKRHIQQHFYQNVSKTQVGVFKCPECPLLFVQKPELMQHVKSTHGVPRNVDELSSLQSSADTSSSRPGSRVPTEPPATSVAARSSSLPSGRWGRPEAHRRVEARPRLRNTGWTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQCEQSFHTPNSLRKHIRNNHDTVKKFYTCGYCTEDSPSFPRPSLLESHISLMHGIRNPDLSQTSKVKPPGGHSPQVNHLKRPVSGVGDAPGTSNGATVSSTKRHKSLFQCAKCSFATDSGLEFQSHIPQHQVDSSTAQCLLCGLCYTSASSLSRHLFIVHKVRDQEEEEEEEAAAAEMAVEVAEPEEGSGEEVPMETRENGLEECAGEPLSADPEARRLLGPAPEDDGGHNDHSQPQASQDQDSHTLSPQV"},{"id":"SEQ_02271","a":"Q15653","g":"NFKBIB","d":"NF-kappa-B inhibitor beta","L":356,"m":[{"c":"Gx[TS][AP]L[HG][LVS]A(x){7,8}φxxL[LY]","u":"20-21","sp":"dispersed","x":"structured_like","cf":"high","why":"Six 20-21 aa repeats arranged in two 3-copy clusters separated by a 59 aa proline/acidic linker share a strongly conserved Gx[TS][AP]L[HG][LVS]A N-terminal signature and a C-terminal φxxL[LY] hydrophobic motif.","i":[[58,78,"GDTALHLAVIHQHEPFLDFLL"],[94,114,"GQTALHLAAILGETSTVEKLY"],[127,147,"GHTALHLACRVGAHACARALL"],[207,226,"GHTPLHVAVIHKDVEMVRLL"],[241,260,"GRSPLHLAVEAQAADVLELL"],[274,293,"GRTPLGSAMLRPNPILARLL"]]}],"s":"MAGVACLGKAADADEWCDSGLGSLGPDAAAPGGPGLGAELGPGLSWAPLVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGDEYDDIVVHSSRSQTRLPPTPASKPLPDDPRPV"},{"id":"SEQ_02272","a":"Q96T58","g":"SPEN","d":"Msx2-interacting protein","L":3664,"m":[{"c":"xψxψx[NG]Lx(x){7,11}ψxxxFx+ΩGxψxxψxφx(x){4,9}φ[AG][FL]ψxΩxxxxxxxxAx(x){14,17}Ωx","u":"70-77","sp":"dispersed","x":"structured_like","cf":"high","why":"Four ~70-77 aa globular repeat units in the N-terminal region separated by variable linkers (256, 26, and 6 aa), anchored by an N-terminal xψxψx[NG]Lx segment, an invariant Fx+ΩG motif followed by alternating hydrophobics, a central φ[AG][FL]ψxΩ hydrophobic core preceding a conserved alanine, and a C-terminal aromatic residue.","i":[[7,79,"HLWVGNLPENVREEKIIEHFKRYGRVESVKILPKRGSEGGVAAFVDFVDIKSAQKAHNSVNKMGDRDLRTDYN"],[336,412,"GIKVQNLPVRSTDTSLKDGLFHEFKKFGKVTSVQIHGTSEERYGLVFFRQQEDQEKALTASKGKLFFGMQIEVTAWI"],[439,511,"TLFIGNLEKTTTYHDLRNIFQRFGEIVDIDIKKVNGVPQYAFLQYCDIASVCKAIKKMDGEYLGNNRLKLGFG"],[518,587,"CVWLDGLSSNVSDQYLTRHFCRYGPVVKVVFDRLKGMALVLYNEIEYAQAAVKETKGRKIGGNKIKVDFA"]]},{"c":"xxV[NTS]xxx","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Sixteen-copy 7-aa tandem array in a G/P/S/T/A/V-rich disordered region (contiguous head-to-tail except for a single 4-aa truncated unit GPVK between copies 3 and 4), defined by an invariant V at position 3, [NTS] at position 4, predominantly [GS] at position 1, and local block conservation (such as GPVNVL[KT] and GTVNAA[PA]).","i":[[2649,2655,"GLVSALT"],[2656,2662,"GLVNVSL"],[2663,2669,"VPVNALK"],[2674,2680,"GSVTTLK"],[2681,2687,"SLVSTPA"],[2688,2694,"GPVNVLK"],[2695,2701,"GPVNVLT"],[2702,2708,"GPVNVLT"],[2709,2715,"TPVNATV"],[2716,2722,"GTVNAAP"],[2723,2729,"GTVNAAA"],[2730,2736,"SAVNATA"],[2737,2743,"SAVTVTA"],[2744,2750,"GAVTAAS"],[2751,2757,"GGVTATT"],[2758,2764,"GTVTMAG"]]}],"s":"MVRETRHLWVGNLPENVREEKIIEHFKRYGRVESVKILPKRGSEGGVAAFVDFVDIKSAQKAHNSVNKMGDRDLRTDYNEPGTIPSAARGLDDTVSIASRSREVSGFRGGGGGPAYGPPPSLHAREGRYERRLDGASDNRERAYEHSAYGHHERGTGGFDRTRHYDQDYYRDPRERTLQHGLYYASRSRSPNRFDAHDPRYEPRAREQFTLPSVVHRDIYRDDITREVRGRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSSSSSDDSPARSVQSAAVPAPTSQLLSSLEKDEPRKSFGIKVQNLPVRSTDTSLKDGLFHEFKKFGKVTSVQIHGTSEERYGLVFFRQQEDQEKALTASKGKLFFGMQIEVTAWIGPETESENEFRPLDERIDEFHPKATRTLFIGNLEKTTTYHDLRNIFQRFGEIVDIDIKKVNGVPQYAFLQYCDIASVCKAIKKMDGEYLGNNRLKLGFGKSMPTNCVWLDGLSSNVSDQYLTRHFCRYGPVVKVVFDRLKGMALVLYNEIEYAQAAVKETKGRKIGGNKIKVDFANRESQLAFYHCMEKSGQDIRDFYEMLAERREERRASYDYNQDRTYYESVRTPGTYPEDSRRDYPARGREFYSEWETYQGDYYESRYYDDPREYRDYRNDPYEQDIREYSYRQRERERERERFESDRDRDHERRPIERSQSPVHLRRPQSPGASPSQAERLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDKSRLERYTKNEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHSPSSQSSETDQENEREQSPEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVEKLKAKLDNDTVKSSALDQKLQVSQTEPAKSDLSKLESVRMKVPKEKGLSSHVEVVEKEGRLKARKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVKKSSPEMEDARVLSKKQPDVSSREVILLREGEAERKPVRKEILKRESKKIKLDRLNTVASPKDCQELASISVGSGSRPSSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDETPERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFGSPKKDVDEYERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDICTKRERNYRSSRQISEDSERTGGSPSVRHGSFHEDEDPIGSPRLLSVKGSPKVDEKVLPYSNITVREESLKFNPYDSSRREQMADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSFPNSIIKRDSLRKRSVRDLEPGEVPSDSDEDGEHKSHSPRASALYESSRLSFLLRDREDKLRERDERLSSSLERNKFYSFALDKTITPDTKALLERAKSLSSSREENWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKIRTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKEEDSDFISGRIYGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDLENSQKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAVIAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPALPSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQDSSPHLTSQRPVDMVQLLKKYPIVWQGLLALKNDTAAVQLHFVSGNNVLAHRSLPLSEGGPPLRIAQRMRLEATQLEGVARRMTVETDYCLLLALPCGRDQEDVVSQTESLKAAFITYLQAKQAAGIINVPNPGSNQPAYVLQIFPPCEFSESHLSRLAPDLLASISNISPHLMIVIASV"},{"id":"SEQ_02274","a":"Q8NDC0","g":"MAPK1IP1L","d":"MAPK-interacting and spindle-stabilizing protein-like","L":245,"m":[{"c":"[GAM]xYP[ATS]P","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Eight non-overlapping 6-aa copies in the P/G-rich disordered region anchored by invariant Y4, P5, and P7 plus strongly conserved G1 (6/8 copies) and small/hydroxyl [ATS]5.","i":[[100,105,"GPYPAP"],[114,119,"GPYPTP"],[159,164,"GQYPTP"],[166,171,"MPYPSP"],[172,177,"GPYPAP"],[203,208,"APYPAP"],[210,215,"GSYPTP"],[216,221,"GLYPTP"]]},{"c":"[PS]x[GV][PA]W[GA][PST]","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Four non-overlapping 7-aa copies organized as two near-tandem pairs (1-aa internal gap) anchored by invariant W5 flanked by conserved [GV][PA] and [GA][PST] positions, non-overlapping with the YPxP repeats.","i":[[141,147,"PLGPWGS"],[149,155,"SSGPWAP"],[187,193,"PPVPWGT"],[195,201,"PPGAWGP"]]}],"s":"MSDEFSLADALPEHSPAKTSAVSNTKPGQPPQGWPGSNPWNNPSAPSSVPSGLPPSATPSTVPFGPAPTGMYPSVPPTGPPPGPPAPFPPSGPSCPPPGGPYPAPTVPGPGPTGPYPTPNMPFPELPRPYGAPTDPAAAGPLGPWGSMSSGPWAPGMGGQYPTPNMPYPSPGPYPAPPPPQAPGAAPPVPWGTVPPGAWGPPAPYPAPTGSYPTPGLYPTPSNPFQVPSGPSGAPPMPGGPHSYH"},{"id":"SEQ_02286","a":"Q9NNX9","g":"VCX3A","d":"Variable charge X-linked protein 3","L":186,"m":[{"c":"PLSQES[EQ][VLM]EE","u":10,"sp":"tandem","x":"disordered_like","cf":"high","why":"Eight head-to-tail tandem 10-aa repeats in the C-terminal acidic/polar disordered region with 8 of 10 positions strictly invariant (PLSQES..EE) and tight [EQ]7 and aliphatic [VLM]8 substitutions.","i":[[103,112,"PLSQESELEE"],[113,122,"PLSQESEVEE"],[123,132,"PLSQESQVEE"],[133,142,"PLSQESEVEE"],[143,152,"PLSQESQVEE"],[153,162,"PLSQESEVEE"],[163,172,"PLSQESQVEE"],[173,182,"PLSQESEMEE"]]}],"s":"MSPKPRASGPPAKATEAGKRKSSSQPSPSDPKKKTTKVAKKGKAVRRGRRGKKGAATKMAAVTAPEAESGPAAPGPSDQPSQELPQHELPPEEPVSEGTQHDPLSQESELEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEMEELPSV"},{"id":"SEQ_02319","a":"Q68BL8","g":"OLFML2B","d":"Olfactomedin-like protein 2B","L":750,"m":[{"c":"[ST]xGS[DS]CxCxCV[VA]xPx[GA]x[DN]xC","u":20,"sp":"dispersed","x":"structured_like","cf":"high","why":"Strongly conserved 20-aa ungapped internal duplication anchored by four identically spaced cysteines (CxCxC...C) plus fixed G, S, V, and P positions and conserved [ST], [VA], [GA], and [DN] pairs separated by a 19-aa linker.","i":[[70,89,"SEGSDCQCKCVVRPLGRDAC"],[109,128,"TSGSSCKCACVAPPSALNPC"]]}],"s":"MAKPRLLVLYFALIVVPAWVSSIVLTGTSEPPDAQTVAPAEDETLQNEADNQENVLSQLLGDYDKVKAMSEGSDCQCKCVVRPLGRDACQRINAGASRKEDFYTVETITSGSSCKCACVAPPSALNPCEGDFRLQKLREADSQDLKLSTIIDMLEGAFYGLDLLKLHSVTTKLVGRVDKLEEEVSKNLTKENEQIKEDMEEIRTEMNKRGKENCSENILDSMPDIRSALQRDAAAAYAHPEYEERFLQEETVSQQINSIELLQTRPLALPEVVKSQRPLQRQVHLRGRPASQPTVIRGITYYKAKVSEEENDIEEQQDEFFSGDNGVDLLIEDQLLRHNGLMTSVTRRPAATRQGHSTAVTSDLNARTAPWSSALPQPSTSDPSIANHASVGPTLQTTSVSPDPTRESVLQPSPQVPATTVAHTATQQPAAPAPPAVSPREALMEAMHTVPVPPTTVRTDSLGKDAPAGWGTTPASPTLSPEEEDDIRNVIGRCKDTLSTITGPTTQNTYGRNEGAWMKDPLAKDERIYVTNYYYGNTLVEFRNLENFKQGRWSNSYKLPYSWIGTGHVVYNGAFYYNRAFTRNIIKYDLKQRYVAAWAMLHDVAYEEATPWRWQGHSDVDFAVDENGLWLIYPALDDEGFSQEVIVLSKLNAADLSTQKETTWRTGLRRNFYGNCFVICGVLYAVDSYNQRNANISYAFDTHTNTQIVPRLLFENEYSYTTQIDYNPKDRLLYAWDNGHQVTYHVIFAY"},{"id":"SEQ_02325","a":"Q9Y468","g":"L3MBTL1","d":"Lethal(3)malignant brain tumor-like protein 1","L":840,"m":[{"c":"-x[FW][SC]W[ES]xYL[ER][ES][QT]xAx[AT][AV]Pxx[AL]Fx(x){5,10}[GS]Fx[LV][GN]MKLE[AG][IV]D[PR]x[HN]P[AS][LM]φx[IV][AL][ST]Vx-Vx[DG]xRφxψHFD[GN][WY][DS]xx[HY]D[FY]Wx[DN][AP]x[HS]P[DY]IHP[AV]GW[CF]xK[QT]G[HK][KP]L[QT]PP","u":"98-103","sp":"periodic","x":"structured_like","cf":"high","why":"Three tandemly arrayed 98-103 aa globular domain repeats separated by 5-6 aa linkers, sharing invariant W..YL, MKLE..D..P, HFD..D[FY]W..P.IHP.GW, and K.G..L.PP anchors with a single 5-10 aa variable internal loop.","i":[[272,374,"ECWSWESYLEEQKAITAPVSLFQDSQAVTHNKNGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPP"],[380,481,"EEFSWSQYLRSTRAQAAPKHLFVSQSHSPPPLGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPP"],[488,585,"DNFCWEKYLEETGASAVPTWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPP"]]}],"s":"MHLVAGDSPGSGPHLPATAFIIPASSATLGLPSSALDVSCFPREPIHVGAPEQVAGCEPVSATVLPQLSAGPASSSTSTVRLLEWTEAAAPPPGGGLRFRISEYKPLNMAGVEQPPSPELRQEGVTEYEDGGAPAGDGEAGPQQAEDHPQNPPEDPNQDPPEDDSTCQCQACGPHQAAGPDLGSSNDGCPQLFQERSVIVENSSGSTSASELLKPMKKRKRREYQSPSEEESEPEAMEKQEEGKDPEGQPTASTPESEEWSSSQPATGEKKECWSWESYLEEQKAITAPVSLFQDSQAVTHNKNGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPPKGYKEEEFSWSQYLRSTRAQAAPKHLFVSQSHSPPPLGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPDPDNFCWEKYLEETGASAVPTWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPPLGPREPSSASPGGCPPLSYRSLPHTRTSKYSFHHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAERNQSRLKAELSDSEASARKKNLSGFSPRKKPRHHGRIGRPPKYRKIPQEDFQTLTPDVVHQSLFMSALSAHPDRSLSVCWEQHCKLLPGVAGISASTVAKWTIDEVFGFVQTLTGCEDQARLFKDEARIVRVTHVSGKTLVWTVAQLGDLVCSDHLQEGKGILETGVHSLLCSLPTHLLAKLSFASDSQY"},{"id":"SEQ_02328","a":"Q9NSC2","g":"SALL1","d":"Sal-like protein 1","L":1324,"m":[{"c":"CxxCx[KNR]x[FL]xxx[GSV][ANV]L[DKQ]xHxxxH","u":21,"sp":"dispersed","x":"structured_like","cf":"high","why":"Nine canonical 21-aa C2H2 zinc-finger repeats (plus a divergent N-terminal C2HC variant at residues 45-65) arranged into four dispersed clusters separated by long disordered linkers, with four tandem pairs sharing an extended higher-order duplication signature (SAL...GERPF...TKGNLK).","i":[[451,471,"CRFCAKVFGSDSALQIHLRSH"],[479,499,"CNICGNRFSTKGNLKVHFQRH"],[708,728,"CIICHRVLSCQSALKMHYRTH"],[736,756,"CKICGRAFTTKGNLKTHYSVH"],[768,788,"CPICQKKFTNAVVLQQHIRMH"],[1003,1023,"CDICGKTFACQSALDIHYRSH"],[1031,1051,"CTVCNRGFSTKGNLKQHMLTH"],[1136,1156,"CNTCGKTFSSSSALQIHERTH"],[1164,1184,"CTICGRAFTTKGNLKVHMGTH"]]}],"s":"MSRRKQAKPQHFQSDPEVASLPRRDGDTEKGQPSRPTKSKDAHVCGRCCAEFFELSDLLLHKKNCTKNQLVLIVNENPASPPETFSPSPPPDNPDEQMNDTVNKTDQVDCSDLSEHNGLDREESMEVEAPVANKSGSGTSSGSHSSTAPSSSSSSSSSSGGGGSSSTGTSAITTSLPQLGDLTTLGNFSVINSNVIIENLQSTKVAVAQFSQEARCGGASGGKLAVPALMEQLLALQQQQIHQLQLIEQIRHQILLLASQNADLPTSSSPSQGTLRTSANPLSTLSSHLSQQLAAAAGLAQSLASQSASISGVKQLPPIQLPQSSSGNTIIPSNSGSSPNMNILAAAVTTPSSEKVASSAGASHVSNPAVSSSSSPAFAISSLLSPASNPLLPQQASANSVFPSPLPNIGTTAEDLNSLSALAQQRKSKPPNVTAFEAKSTSDEAFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNICGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEHLDNIPTSTGIPYGMSIPPEKPVTSWLDTKPVLPTLTTSVGLPLPPTLPSLIPFIKTEEPAPIPISHSATSPPGSVKSDSGGPESATRNLGGLPEEAEGSTLPPSGGKSEESGMVTNSVPTASSSVLSSPAADCGPAGSATTFTNPLLPLMSEQFKAKFPFGGLLDSAQASETSKLQQLVENIDKKATDPNECIICHRVLSCQSALKMHYRTHTGERPFKCKICGRAFTTKGNLKTHYSVHRAMPPLRVQHSCPICQKKFTNAVVLQQHIRMHMGGQIPNTPVPDSYSESMESDTGSFDEKNFDDLDNFSDENMEDCPEGSIPDTPKSADASQDSLSSSPLPLEMSSIAALENQMKMINAGLAEQLQASLKSVENGSIEGDVLTNDSSSVGGDMESQSAGSPAISESTSSMQALSPSNSTQEFHKSPSIEEKPQRAVPSEFANGLSPTPVNGGALDLTSSHAEKIIKEDSLGILFPFRDRGKFKNTACDICGKTFACQSALDIHYRSHTKERPFICTVCNRGFSTKGNLKQHMLTHQMRDLPSQLFEPSSNLGPNQNSAVIPANSLSSLIKTEVNGFVHVSPQDSKDTPTSHVPSGPLSSSATSPVLLPALPRRTPKQHYCNTCGKTFSSSSALQIHERTHTGEKPFACTICGRAFTTKGNLKVHMGTHMWNSTPARRGRRLSVDGPMTFLGGNPVKFPEMFQKDLAARSGSGDPSSFWNQYAAALSNGLAMKANEISVIQNGGIPPIPGSLGSGNSSPVSGLTGNLERLQNSEPNAPLAGLEKMASSENGTNFRFTRFVEDSKEIVTS"},{"id":"SEQ_02333","a":"Q96T23","g":"RSF1","d":"Remodeling and spacing factor 1","L":1441,"m":[{"c":"K[DR]ISTI[TL]","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three copies in disordered-like regions share five invariant anchor positions (KxISTIx) with constrained charged [DR] and [TL] substitutions; the C-terminal pair forms a closely spaced duplication sharing an extended RGKDISTI[TL] sequence, while the N-terminal copy also shares a downstream GHxGK flank with the second copy.","i":[[426,432,"KRISTIT"],[1050,1056,"KDISTIT"],[1061,1067,"KDISTIL"]]}],"s":"MATAAAAAAVMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPPPDVGNGEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEKKGYLEMSVECKLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRMYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYRIESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLVDYVCNSEQL"},{"id":"SEQ_02336","a":"O75410","g":"TACC1","d":"Transforming acidic coiled-coil-containing protein 1","L":805,"m":[{"c":"[AG]SYHF[SD]P-xφDEox[SD]Pφ","u":17,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Strongly conserved 17-aa dispersed duplication in the central disordered region anchored by an invariant SYHF tetrapeptide, two fixed prolines ([SD]P motifs in both positions), an invariant DE dipeptide, and conserved acidic (-) and flanking hydrophobic (L/F) positions.","i":[[262,278,"ASYHFSPEELDENTSPL"],[413,429,"GSYHFDPDNFDESMDPF"]]}],"s":"MAFSPWQILSPVQWAKWTWSAVRGGAAGEDEAGGPEGDPEEEDSQAETKSLSFSSDSEGNFETPEAETPIRSPFKESCDPSLGLAGPGAKSQESQEADEQLVAEVVEKCSSKTCSKPSENEVPQQAIDSHSVKNFREEPEHDFSKISIVRPFSIETKDSTDISAVLGTKAAHGCVTAVSGKALPSSPPDALQDEAMTEGSMGVTLEASAEADLKAGNSCPELVPSRRSKLRKPKPVPLRKKAIGGEFSDTNAAVEGTPLPKASYHFSPEELDENTSPLLGDARFQKSPPDLKETPGTLSSDTNDSGVELGEESRSSPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKDGISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVKKHETQSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKLGKTD"},{"id":"SEQ_02340","a":"Q9Y618","g":"NCOR2","d":"Nuclear receptor corepressor 2","L":2514,"m":[{"c":"GSI[TA]xG[ITA]P","u":8,"sp":"dispersed","x":"mixed","cf":"high","why":"Five dispersed 8-aa copies across residues 1206-1527 anchored by five invariant positions (G1, S2, I3, G6, P8), tightly constrained [TA]4 and [ITA]7 positions, and polar/basic residues (K/H/Q/R) at position 5.","i":[[1206,1213,"GSITKGIP"],[1227,1234,"GSITHGTP"],[1353,1360,"GSITQGIP"],[1449,1456,"GSITQGTP"],[1520,1527,"GSIARGAP"]]},{"c":"W[ST]E[EQ]ExETφ+xxφψ[EQ]H[GP]+NΩxφIAxφψxxKTV[AS][EQ]CxxΩYΩxxKKx[EQ]Nφxxψψ","u":52,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 52-aa structured-like domain copies separated by a 127-aa disordered linker, sharing 17 identical anchor residues (including W, ExET, H, N, IA, KTV, C, Y, KK, N) and 18 physicochemically conserved hydrophobic/aromatic/polar positions.","i":[[432,483,"WSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLV"],[615,666,"WTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEIL"]]},{"c":"ψEPVSP[PV]","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 7-aa copies located in N- and C-terminal disordered regions sharing an invariant EPVSP core flanked by a conserved large aliphatic residue (L/V/I) at position 1 and [PV] at position 7.","i":[[145,151,"LEPVSPP"],[2050,2056,"VEPVSPV"],[2219,2225,"IEPVSPP"]]}],"s":"MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQPQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRPSPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQRYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSPSRLDRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRAISSASIEGLMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLRREAKLLKREGTPPPPPPSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREELRHTPELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDVMADARALERACYEESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAGHLPRGSPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRGYPDTAALENRQTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGGGGGSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMGLEAIIRKALMGKYDQWEESPPLSANAFNPLNASASLPAAMPITAADGRSDHTLTSPGGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWEDRPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYETLSDSE"},{"id":"SEQ_02342","a":"Q8IVF1","g":"NUTM2A","d":"NUT family member 2A","L":878,"m":[{"c":"A[CR][LR]PPPRP[QH]R[PR][AV]","u":12,"sp":"periodic","x":"disordered_like","cf":"high","why":"Three contiguous 14-15 aa repeats in a proline/basic-rich disordered region share a strongly conserved 12-aa core anchored by invariant A1, P4-P6, R7, P8, and R10 positions, separated by short 2-3 aa (TK/ETK) C-terminal tails.","i":[[464,475,"ACLPPPRPQRPV"],[478,489,"ARRPPPRPHRRA"],[493,504,"ARLPPPRPQRPA"]]}],"s":"MEVKGPSGRSFCCESEGQFKSCLKRHTPSLLLPSSWKGNSGSCLMAKALHRMSPTPNSCPLPLPLCRMSGVLCSRNLFTFKFSLFQLDSGASGEPGHSLGLTLGFSHCGNCQTAVVSAQPEGMASNGAYPALGPGVTANPGTSLSVFTALPFTTPAPGPAHGPLLVTAGAPPGGPLVLSTLPSTPLVTEQDGCGPSGAGASNVFVQMRTEVGPVKAAQAQTLVLTQAPLVWQAPGALCGGVVCPPPLLLAAAPVVPVMAAQVVGGTQACEGGWSQGLPLPPPPPPAAQLPPIVSQGNAGPWPQGAHGEGSLASSQAKAPPDDSCNPRSVYENFRLWQHYKPLARRHLPQSPDTEALSCFLIPVLRSLARRKPTMTLEEGLWRAMREWQHTSNFDRMIFYEMAEKFLEFEAEEEMQIQKSQWMKGPQCLPPPATPRLEPRGPPAPEVVKQPVYLPSKAGPKAPTACLPPPRPQRPVTKARRPPPRPHRRAETKARLPPPRPQRPAETKVPEEIPPEVVQEYVDIMEELLGPSLGATGEPEKQREEGEVKQPQEEDWTPPDPGLLSYTDKLCSQKDFVTKVEAVIHPQFLEELLSPDPQMDFLALSQELEQEEGLTLAQLVEKRLLPLKEKQHARAAPSRGTARLDSSSSKFAAGQGAERDVPVPQQGVGMETCPPQTTARDSQGRGRAHTGMARSKDSVVLLGCQDSPGLRAARPTSPPQDHRPTCPGVGTKDALDLPGGSPVRESHGLAQGSSEEEELPSLAFLLGSQHKLLPWWLPQSPVPASGLLSPEKWGPQGTHQFPSAERRGLNLAPSPANKAKKRPLFGSLSPAEKTPHPGPGLRVSGEQSLTWGLGGPSQSQKRKGDPLVSRKEKKQRCSQ"},{"id":"SEQ_02362","a":"Q9Y233","g":"PDE10A","d":"cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A","L":1055,"m":[{"c":"KEGKP(x){13,15}ψ[SA][AG]xVA+[ST]xxxLxψxDφφ[GA]D[EP]RF[PN]RxxxLx[ST]GxxxxoψLCψPIV[ST]x(x){0,1}G[DS]ψIGψψxψφx[HK]φ[GS]xxAF[CS]x[ST]xxxxφxφxφφΩ[AC][SA]ψAψHxφoψx[RH]x(x){40,55}EψxxxxFDIG","u":"161-175","sp":"tandem","x":"structured_like","cf":"high","why":"Two large tandemly duplicated structured domains (separated by a 2-residue EE linker) sharing invariant N/C boundary motifs (KEGKP and FDIG) and a strongly conserved ~91-aa hydrophobic/catalytic-like core anchored by D[EP]RF[PN]R, LCψPIV, G[DS]ψIGψψ, AF, and ΩxxψAψH.","i":[[409,583,"KEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIG"],[586,746,"KEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIG"]]}],"s":"MASLEEPLAPRPQGPLPAAGDEPGCGPGKLRPEPRLSAAGGGSAAGPGPAPEWPGRGRAERAAPPRPPLSSAGRPSPAGGPGALSARGGGCGWVAARAPLALAFSSRVPSSSPSFFYFWPPPPPPPPSFLPSSSAFHLPVRLPGREGAAAAAAAGGGGDAGGGGGGGQEAAPLSVPTSSSHRGGGGSGGGRRRLFLSPALQGLLLPARAGPRPPPPPRLPLGQAARRAGSPGFPGAGPGGGGQTPRRPQGASFALAAAAALLFGSDMEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED"},{"id":"SEQ_02363","a":"Q9NQ38","g":"SPINK5","d":"Serine protease inhibitor Kazal-type 5","L":1064,"m":[{"c":"Cxx[FY](x){7,8}[FLY]xC[TP]xxxx[PAF]φx[GSD]x[DY]Gxx[HYF]xNCx[MLT]Cxxxφ","u":"40-41","sp":"periodic","x":"structured_like","cf":"high","why":"Fifteen periodic ~41-aa disulfide-rich domains arrayed across the full sequence (separated by ~17-34 aa polar/charged linkers), strictly conserving four cysteines (C-x12,13-C-x18-C-x2-C) alongside invariant G and N positions and conserved aromatic/hydrophobic anchors.","i":[[30,70,"CHEFQAFMKNGKLFCPQDKKFFQSLDGIMFINKCATCKMIL"],[97,137,"CDDFKKGERDGDFICPDYYEAVCGTDGKTYDNRCALCAENA"],[161,201,"CSAFRPFVRDGRLGCTRENDPVLGPDGKTHGNKCAMCAELF"],[225,265,"CKEYEKQVRNGRLFCTRESDPVRGPDGRMHGNKCALCAEIF"],[297,337,"CSQYQNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQAYF"],[367,407,"CSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFF"],[437,477,"CSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFF"],[496,536,"CSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVF"],[567,607,"CSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTCSMCEAFF"],[632,672,"CDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAVF"],[707,747,"CAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKL"],[774,814,"CDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKL"],[849,889,"CREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIF"],[916,956,"CSEFRNYIRNNELICPRENDPVHGADGKFYTNKCYMCRAVF"],[993,1032,"CKDYRVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLCHENL"]]},{"c":"K[VA]KRE[AI]","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Four non-overlapping copies of a conserved dibasic-centered hexapeptide motif (invariant K-x-K-R-E core flanked by constrained aliphatic [VA] and [AI] positions) dispersed within the disordered inter-domain linkers preceding repeat units 5, 8, 9, and 10.","i":[[288,293,"KVKREI"],[486,491,"KAKREA"],[557,562,"KVKREA"],[622,627,"KVKREA"]]}],"s":"MKIATVSVLLPLALCLIQDAASKNEDQEMCHEFQAFMKNGKLFCPQDKKFFQSLDGIMFINKCATCKMILEKEAKSQKRARHLARAPKATAPTELNCDDFKKGERDGDFICPDYYEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNPEQDVCSAFRPFVRDGRLGCTRENDPVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCTRESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQYQNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKATSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKSSSKPSNNAKDECSEFRNYIRNNELICPRENDPVHGADGKFYTNKCYMCRAVFLTEALERAKLQEKPSHVRASQEEDSPDSFSSLDSEMCKDYRVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESSTPGTTAASMPPSDE"},{"id":"SEQ_02386","a":"O95201","g":"ZNF205","d":"Transcriptional repressor RHIT","L":554,"m":[{"c":"+[PS][YH]xCxxC[GAR]KxF[STG]x[RSH]SxLxxHxx[TI]H[TR][GT]x","u":28,"sp":"tandem","x":"structured_like","cf":"high","why":"Eight head-to-tail 28-residue tandem repeats in the C-terminal half anchored by invariant CxxC, KxF, SxL, and Hxx[TI]H cores along with conserved N-terminal +[PS][YH] and C-terminal [TR][GT] linker positions.","i":[[306,333,"KSYRCEQCGKGFSWHSHLVTHRRTHTGE"],[334,361,"KPYACTDCGKRFGRSSHLIQHQIIHTGE"],[362,389,"KPYTCPACRKSFSHHSTLIQHQRIHTGE"],[390,417,"KPYVCDRCAKRFTRRSDLVTHQGTHTGA"],[418,445,"KPHKCPICAKCFTQSSALVTHQRTHTGV"],[446,473,"KPYPCPECGKCFSQRSNLIAHNRTHTGE"],[474,501,"KPYHCLDCGKSFSHSSHLTAHQRTHRGV"],[502,529,"RPYACPLCGKSFSRRSNLHRHEKIHTTG"]]}],"s":"MSADGGGIQDTQDKETPPEVPDRGHPHQEMPSKLGEAVPSGDTQESLHIKMEPEEPHSEGASQEDGAQGAWGWAPLSHGSKEKALFLPGGALPSPRIPVLSREGRTRDRQMAAALLTAWSQMPVTFEDVALYLSREEWGRLDHTQQNFYRDVLQKKNGLSLGFPFSRPFWAPQAHGKGEASGSSRQAGDEKEWRGACTGAVEVGQRVQTSSVAALGNVKPFRTRAGRVQWGVPQCAQEAACGRSSGPAKDSGQPAEPDRTPDAAPPDPSPTEPQEYRVPEKPNEEEKGAPESGEEGLAPDSEVGRKSYRCEQCGKGFSWHSHLVTHRRTHTGEKPYACTDCGKRFGRSSHLIQHQIIHTGEKPYTCPACRKSFSHHSTLIQHQRIHTGEKPYVCDRCAKRFTRRSDLVTHQGTHTGAKPHKCPICAKCFTQSSALVTHQRTHTGVKPYPCPECGKCFSQRSNLIAHNRTHTGEKPYHCLDCGKSFSHSSHLTAHQRTHRGVRPYACPLCGKSFSRRSNLHRHEKIHTTGPKALAMLMLGAAAAGALATPPPAPT"},{"id":"SEQ_02395","a":"Q9Y5Y9","g":"SCN10A","d":"Sodium channel protein type 10 subunit alpha","L":1956,"m":[{"c":"ψ[SV][VTE][HDR][SPQ]φ[FA][SED]x[FT]IxφxIx[VL][NS]xxx[ML](x){10,21}x[VF]F[TV]φφ[FY][TV][FAG]E[AMC][LV]φKφφAx(x){8,13}W[NC]φ[LF]D[FC][SIL][VI][IV][TNV]ψ[AS]φφ[GES][TL](x){9,20}[LI]R[TSL]φRφ[LG]Rx[LF]+[TLA]φxxφx[GT]ψ[KRN][VT]ψψx[AI][LI]xx[SA]ψ[KGP][KAS][LI]x[DN]ψ[TLG][IL]ψ[TLC]φφxφ[SFL][VI][FY][AS][LI]φGxo[LS][FL](x){57,105}φ[IL]φFx[LTI]φ[IM]φ[LFS][GF]xφφ[LVT][VLN]N[LM]φψ[AG][VL]ψ[TLI]x[ASN]Ω","u":"233-275","sp":"dispersed","x":"structured_like","cf":"high","why":"Four large homologous six-helix transmembrane domain duplications (233-275 aa) separated by variable intracellular linkers (50-260 aa). Each copy shares five strictly aligned hydrophobic/amphipathic blocks anchored by invariant I/F/E/K/A, Wxφ[LF]D, a gapless 55-residue basic RxφRφxRxx+ sensor-to-G-hinge segment, and a C-terminal F...Nψφψ[AG]...Ω helix flanking a variable 57-105 aa loop.","i":[[126,400,"VSVHSWFSLFITVTILVNCVCMTRTDLPEKIEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAY"],[661,893,"LVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSF"],[1148,1421,"IVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNF"],[1472,1725,"IVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENF"]]}],"s":"MEFPIGSLETNNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKACNQLPKFYGELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRTDLPEKIEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDHESHRGSLLLGGGAGQQGPLPRSPLPQPSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSFFSRSCPFPQPKAEPELVVKLPLSSSKAENHIAANTARGSSGGLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQKAYRSYVLHRSMALSNTPCVPRAEEEAASLPDEGFVAFTANENCVLPDKSETASATSFPPSYESVTRGLSDRVNMRTSSSIQNEDEATSMELIAPGP"},{"id":"SEQ_02397","a":"P38398","g":"BRCA1","d":"Breast cancer type 1 susceptibility protein","L":1863,"m":[{"c":"E[VI]GSSx[NE]","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three contiguous head-to-tail 7-residue repeats in the central disordered region (aa 1046-1066, flanked immediately N-terminally by a related divergent EASSSNIN unit and C-terminally by N) anchored by invariant E1, G3, S4, S5 and aliphatic [VI]2.","i":[[1046,1052,"EVGSSTN"],[1053,1059,"EVGSSIN"],[1060,1066,"EIGSSDE"]]}],"s":"MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACEFSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPLCERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNAKVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRKKASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRPTSGLHPEDFIKKADLAVQKTPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSIQNEKNPNPIESLEKESAFKTKAEPISSSISNMELELNIHNSKAPKKNRLRRKSSTRHIHALELVVSRNLSPPNCTELQIDSCSSSEEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTFPELKLTNAPGSFTKCSNTSELKEFVNPSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESSSISLVPGTDYGTQESISLLEVSTLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNRNDTEGFKYPLGHEVNHSRETSIEMEESELDAQYLQNTFKVSKRQSFAPFSNPGNAEEECATFSAHSGSLKKQSPKVTFECEQKEENQGKNESNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIKGGSRFCLSSQFRGNETGLITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHSMSPEREMGNENIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDENIQAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPYLISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELSRSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTVATECLSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQIPHSHY"},{"id":"SEQ_02415","a":"Q9H5I5","g":"PIEZO2","d":"Piezo-type mechanosensitive ion channel component 2","L":2752,"m":[{"c":"SQ+[GS]S","u":5,"sp":"periodic","x":"disordered_like","cf":"medium","why":"Three periodically spaced copies (5-6 aa linkers, 10-11 aa period) of a 5-residue SQ+[GS]S motif in an internal disordered loop, anchored by invariant S1, Q2, and S5 residues alongside a conserved basic position (+3: R/K) and constrained [GS]4 choice.","i":[[2106,2110,"SQRSS"],[2116,2120,"SQRGS"],[2127,2131,"SQKGS"]]}],"s":"MASEVVCGLIFRLLLPICLAVACAFRYNGLSFVYLIYLLLIPLFSEPTKTTMQGHTGRLLKSLCFISLSFLLLHIIFHITLVSLEAQHRIAPGYNCSTWEKTFRQIGFESLKGADAGNGIRVFVPDIGMFIASLTIWLLCRNIVQKPVTDEAAQSNPEFENEELAEGEKIDSEEALIYEEDFNGGDGVEGELEESTKLKMFRRLASVASKLKEFIGNMITTAGKVVVTILLGSSGMMLPSLTSSVYFFVFLGLCTWWSWCRTFDPLLFSCLCVLLAIFTAGHLIGLYLYQFQFFQEAVPPNDYYARLFGIKSVIQTDCSSTWKIIVNPDLSWYHHANPILLLVMYYTLATLIRIWLQEPLVQDEGTKEEDKALACSPIQITAGRRRSLWYATHYPTDERKLLSMTQDDYKPSDGLLVTVNGNPVDYHTIHPSLPMENGPGKADLYSTPQYRWEPSDESSEKREEEEEEKEEFEEERSREEKRSIKVHAMVSVFQFIMKQSYICALIAMMAWSITYHSWLTFVLLIWSCTLWMIRNRRKYAMISSPFMVVYGNLLLILQYIWSFELPEIKKVPGFLEKKEPGELASKILFTITFWLLLRQHLTEQKALQEKEALLSEVKIGSQENEEKDEELQDIQVEGEPKEEEEEEAKEEKQERKKVEQEEAEEEDEQDIMKVLGNLVVAMFIKYWIYVCGGMFFFVSFEGKIVMYKIIYMVLFLFCVALYQVHYEWWRKILKYFWMSVVIYTMLVLIFIYTYQFENFPGLWQNMTGLKKEKLEDLGLKQFTVAELFTRIFIPTSFLLVCILHLHYFHDRFLELTDLKSIPSKEDNTIYRLAHPEGSLPDLTMMHLTASLEKPEVRKLAEPGEEKLEGYSEKAQKGDLGKDSEESEEDGEEEEESEEEEETSDLRNKWHLVIDRLTVLFLKFLEYFHKLQVFMWWILELHIIKIVSSYIIWVSVKEVSLFNYVFLISWAFALPYAKLRRLASSVCTVWTCVIIVCKMLYQLQTIKPENFSVNCSLPNENQTNIPFNELNKSLLYSAPIDPTEWVGLRKSSPLLVYLRNNLLMLAILAFEVTIYRHQEYYRGRNNLTAPVSRTIFHDITRLHLDDGLINCAKYFINYFFYKFGLETCFLMSVNVIGQRMDFYAMIHACWLIAVLYRRRRKAIAEIWPKYCCFLACIITFQYFICIGIPPAPCRDYPWRFKGASFNDNIIKWLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCRSYLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGTLVHNSCWLIQAFSLACTVKGYQMPAANSPCTLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLSLTQEPGEGQDMQKLSEEDDEREADKQKAKGKKKQWWRPWVDHASMVRSGDYYLFETDSEEEEEEELKKEDEEPPRRSAFQFVYQAWITDPKTALRQRHKEKKRSAREERKRRRKGSKEGPVEWEDREDEPIKKKSDGPDNIIKRIFNILKFTWVLFLATVDSFTTWLNSISREHIDISTVLRIERCMLTREIKKGNVPTRESIHMYYQNHIMNLSRESGLDTIDEHPGAASGAQTAHRMDSLDSHDSISSEPTQCTMLYSRQGTTETIEEVEAEQEEEAGSTAPEPREAKEYEATGYDVGAMGAEEASLTPEEELTQFSTLDGDVEAPPSYSKAVSFEHLSFGSQDDSAGKNRMAVSPDDSRTDKLGSSILPPLTHELTASELLLKKMFHDDELEESEKFYVGQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMVSASMITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKNVEVNKDKPYHPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDEDDMTESGMAREESDDELSLGHGRRDSSDSLKSINLAASVESVHVTFPEQQTAVRRKRSGSSSEPSQRSSFSSNRSQRGSTSTRNSSQKGSSVLSIKQKGKRELYMEKLQEHLIKAKAFTIKKTLEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSLWTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIAKMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDITIILSRDNTTKYNSEWWVLNLTGNRIYNPNSQALELVVFNDKVSPPSLGFLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREKTN"},{"id":"SEQ_02428","a":"Q96PU4","g":"UHRF2","d":"E3 ubiquitin-protein ligase UHRF2","L":802,"m":[{"c":"RAR[LT]I(x){1,7}K[VW]NEL(x){8,18}G[AF]WF-AxIx[ST]ψ","u":"36-40","sp":"dispersed","x":"structured_like","cf":"high","why":"Two internally duplicated 36-40 aa structured segments separated by an 80-aa disordered linker share three colinear conserved blocks (RAR[LT]I, K[VW]NEL, and G[AF]WF-AxIx[ST]ψ) separated by two variable-length loops.","i":[[116,151,"RARLIDPGFGIYKVNELVDARDVGLGAWFEAHIHSV"],[232,271,"RARTILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTL"]]}],"s":"MWIQVRTIDGSKTCTIEDVSRKATIEELRERVWALFDVRPECQRLFYRGKQLENGYTLFDYDVGLNDIIQLLVRPDPDHLPGTSTQIEAKPCSNSPPKVKKAPRVGPSNQPSTSARARLIDPGFGIYKVNELVDARDVGLGAWFEAHIHSVTRASDGQSRGKTPLKNGSSCKRTNGNIKHKSKENTNKLDSVPSTSNSDCVAADEDVIYHIQYDEYPESGTLEMNVKDLRPRARTILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTISRTKKELRVKIFLGGSEGTLNDCKIISVDEIFKIERPGAHPLSFADGKFLRRNDPECDLCGGDPEKKCHSCSCRVCGGKHEPNMQLLCDECNVAYHIYCLNPPLDKVPEEEYWYCPSCKTDSSEVVKAGERLKMSKKKAKMPSASTESRRDWGRGMACVGRTRECTIVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLVLAGGFADEVDRGDEFTYTGSGGKNLAGNKRIGAPSADQTLTNMNRALALNCDAPLDDKIGAESRNWRAGKPVRVIRSFKGRKISKYAPEEGNRYDGIYKVVKYWPEISSSHGFLVWRYLLRRDDVEPAPWTSEGIERSRRLCLRLQYPAGYPSDKEGKKPKGQSKKQPSGTTKRPISDDDCPSASKVYKASDSAEAIEAFQLTPQQQHLIREDCQNQKLWDEVLSHLVEGPNFLKKLEQSFMCVCCQELVYQPVTTECFHNVCKDCLQRSFKAQVFSCPACRHDLGQNYIMIPNEILQTLLDLFFPGYSKGR"},{"id":"SEQ_02429","a":"Q9H4Z2","g":"ZNF335","d":"Zinc finger protein 335","L":1342,"m":[{"c":"[FYH]xCxxCxxxxxxxxxφxxH(x){3,4}H","u":"23-24","sp":"dispersed","x":"structured_like","cf":"high","why":"Thirteen 23-24 aa Cys2-His2 repeats share invariant CxxC and H(x){3,4}H anchors, an N-terminal [FYH] residue, and a strictly conserved hydrophobic residue (φ) three positions before the first histidine, arranged in one isolated copy and two multi-copy arrays (often linked by 5-aa xxxKP spacers).","i":[[245,268,"FKCKMCQYRSSTKATLLRHMRERH"],[465,487,"FLCRICGSRFLSHEDLRFHVNSH"],[495,517,"FKCLQCSYRSRRWSSLKEHMFNH"],[523,545,"YKCDECSYTSVYRKDVIRHAAVH"],[562,584,"FPCPVCGRVYPMQKRLTQHMKTH"],[590,612,"HMCDKCGKSFKKRYTFKMHLLTH"],[621,643,"FKCEFCEFVCEDKKALLNHQLSH"],[649,672,"FKCSFCPYRTFREDFLLSHVAVKH"],[678,701,"FACEYCHFSTRHKKNLRLHVRCRH"],[1019,1041,"FSCKICAEAFPGRAEMESHKRAH"],[1047,1069,"FKCPDCPFSARQWPEVRAHMAQH"],[1075,1097,"HQCSQCSFASKNKKDLRRHMLTH"],[1103,1126,"FACHLCGQRFNRNGHLKFHIQRLH"]]}],"s":"MEENEVESSSDAAPGPGRPEEPSESGLGVGTSEAVSADSSDAAAAPGQAEADDSGVGQSSDRGSRSQEEVSESSSSADPLPNSYLPDSSSVSHGPVAGVTGGPPALVHSSALPDPNMLVSDCTASSSDLGSAIDKIIESTIGPDLIQNCITVTSAEDGGAETTRYLILQGPDDGAPMTSPMSSSTLAHSLAAIEALADGPTSTSTCLEAQGGPSSPVQLPPASGAEEPDLQSLEAMMEVVVVQQFKCKMCQYRSSTKATLLRHMRERHFRPVAAAAAAAGKKGRLRKWSTSTKSQEEEGPEEEDDDDIVDAGAIDDLEEDSDYNPAEDEPRGRQLRLQRPTPSTPRPRRRPGRPRKLPRLEISDLPDGVEGEPLVSSQSGQSPPEPQDPEAPSSSGPGHLVAMGKVSRTPVEAGVSQSDAENAAPSCPDEHDTLPRRRGRPSRRFLGKKYRKYYYKSPKPLLRPFLCRICGSRFLSHEDLRFHVNSHEAGDPQLFKCLQCSYRSRRWSSLKEHMFNHVGSKPYKCDECSYTSVYRKDVIRHAAVHSRDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQAVANRRFKCEFCEFVCEDKKALLNHQLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHFSTRHKKNLRLHVRCRHASSFEEWGRRHPEEPPSRRRPFFSLQQIEELKQQHSAAPGPPPSSPGPPEIPPEATTFQSSEAPSLLCSDTLGGATIIYQQGAEESTAMATQTALDLLLNMSAQRELGGTALQVAVVKSEDVEAGLASPGGQPSPEGATPQVVTLHVAEPGGGAAAESQLGPPDLPQITLAPGPFGGTGYSVITAPPMEEGTSAPGTPYSEEPAGEAAQAVVVSDTLKEAGTHYIMATDGTQLHHIELTADGSISFPSPDALASGAKWPLLQCGGLPRDGPEPPSPAKTHCVGDSQSSASSPPATSKALGLAVPPSPPSAATAASKKFSCKICAEAFPGRAEMESHKRAHAGPGAFKCPDCPFSARQWPEVRAHMAQHSSLRPHQCSQCSFASKNKKDLRRHMLTHTKEKPFACHLCGQRFNRNGHLKFHIQRLHSPDGRKSGTPTARAPTQTPTQTIILNSDDETLATLHTALQSSHGVLGPERLQQALSQEHIIVAQEQTVTNQEEAAYIQEITTADGQTVQHLVTSDNQVQYIISQDGVQHLLPQEYVVVPEGHHIQVQEGQITHIQYEQGAPFLQESQIQYVPVSPGQQLVTQAQLEAAAHSAVTAVADAAMAQAQGLFGTDETVPEHIQQLQHQGIEYDVITLADD"},{"id":"SEQ_02433","a":"Q9ULW6","g":"NAP1L2","d":"Nucleosome assembly protein 1-like 2","L":460,"m":[{"c":"E-[AT]AAG[LS]G--G[EK]xG","u":14,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three head-to-tail tandem 14-residue repeats in the N-terminal acidic disordered tail anchored by invariant E1, A4-A5, G6, G8, G11, and G14 positions plus conserved acidic pairs (positions 2 and 9-10).","i":[[35,48,"EDAAAGLGDDGKCG"],[49,62,"EEAAAGLGEEGENG"],[63,76,"EDTAAGSGEDGKKG"]]}],"s":"MAESENRKELSESSQEEAGNQIMVEGLGEHLERGEDAAAGLGDDGKCGEEAAAGLGEEGENGEDTAAGSGEDGKKGGDTDEDSEADRPKGLIGYVLDTDFVESLPVKVKYRVLALKKLQTRAANLESKFLREFHDIERKFAEMYQPLLEKRRQIINAIYEPTEEECEYKSDSEDCDDEEMCHEEMYGNEEGMVHEYVDEDDGYEDYYYDYAVEEEEEEEEEDDIEATGEENKEEEDPKGIPDFWLTVLKNVDTLTPLIKKYDEPILKLLTDIKVKLSDPGEPLSFTLEFHFKPNEYFKNELLTKTYVLKSKLAYYDPHPYRGTAIEYSTGCEIDWNEGKNVTLKTIKKKQKHRIWGTIRTVTEDFPKDSFFNFFSPHGITSNGRDGNDDFLLGHNLRTYIIPRSVLFFSGDALESQQEGVVREVNDAIYDKIIYDNWMAAIEEVKACCKNLEALVEDIDR"},{"id":"SEQ_02441","a":"Q15020","g":"SART3","d":"Spliceosome associated factor 3, U4/U6 recycling protein","L":963,"m":[{"c":"xxxψΩxx[YW]xxφ(x){12,21}[FYH]x+Aψxx","u":"30-39","sp":"dispersed","x":"structured_like","cf":"high","why":"Nine copies of a 30-39 aa antiparallel helix-turn-helix repeat anchored by an N-terminal aromatic triad (Ωxx[YW]xxφ) and a highly conserved C-terminal [FYH]x+Aψxx helix motif, separated by short variable turns and one longer linker.","i":[[145,179,"TEELWLEWLHDEISMAQDGLDREHVYDLFEKAVKD"],[182,216,"CPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSS"],[224,257,"GLALWEAYREFESAIVEAARLEKVHSLFRRQLAI"],[262,291,"MEATFAEYEEWSEDPIPESVIQNYNKALQQ"],[309,339,"RLAEYQAYIDFEMKIGDPARIQLIFERALVE"],[343,374,"VPDLWIRYSQYLDRQLKVKDLVLSVHNRAIRN"],[378,409,"TVALWSRYLLAMERHGVDHQVISVTFEKALNA"],[417,455,"YVEIWQAYLDYLRRRVDFKQDSSKELEELRAAFTRALEY"],[507,537,"YANMWLEYYNLERAHGDTQHCRKALHRAVQC"]]},{"c":"[TK]ψF[VI]S[NG]LPΩS(x){13,15}G[ET]V(x){7,8}NR(x){4,5}GxxYVEΩxxExxAxQAψ(x){1,2}MDxxxψxxxxψxV","u":"72-73","sp":"dispersed","x":"structured_like","cf":"high","why":"Two-copy internal duplication of a ~72-73 aa globular domain separated by a 25 aa linker, sharing conserved ψF[VI]S[NG]LPΩS, G[ET]V...NR, and GxxYVEΩxxExxAxQAψ(x){1,2}MD core motifs across the full domain length.","i":[[705,777,"TVFVSNLPYSMQEPDTKLRPLFEACGEVVQIRPIFSNRGDFRGYCYVEFKEEKSALQALEMDRKSVEGRPMFV"],[802,873,"KLFISGLPFSCTKEELEEICKAHGTVKDLRLVTNRAGKPKGLAYVEYENESQASQAVMKMDGMTIKENIIKV"]]}],"s":"MATAAETSASEPEAESKAGPKADGEEDEVKAARTRRKVLSRAVAAATYKTMGPAWDQQEEGVSESDGDEYAMASSAESSPGEYEWEYDEEEEKNQLEIERLEEQLSINVYDYNCHVDLIRLLRLEGELTKVRMARQKMSEIFPLTEELWLEWLHDEISMAQDGLDREHVYDLFEKAVKDYICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLALWEAYREFESAIVEAARLEKVHSLFRRQLAIPLYDMEATFAEYEEWSEDPIPESVIQNYNKALQQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFERALVENCLVPDLWIRYSQYLDRQLKVKDLVLSVHNRAIRNCPWTVALWSRYLLAMERHGVDHQVISVTFEKALNAGFIQATDYVEIWQAYLDYLRRRVDFKQDSSKELEELRAAFTRALEYLKQEVEERFNESGDPSCVIMQNWARIEARLCNNMQKARELWDSIMTRGNAKYANMWLEYYNLERAHGDTQHCRKALHRAVQCTSDYPEHVCEVLLTMERTEGSLEDWDIAVQKTETRLARVNEQRMKAAEKEAALVQQEEEKAEQRKRARAEKKALKKKKKIRGPEKRGADEDDEKEWGDDEEEQPSKRRRVENSIPAAGETQNVEVAAGPAGKCAAVDVEPPSKQKEKAASLKRDMPKVLHDSSKDSITVFVSNLPYSMQEPDTKLRPLFEACGEVVQIRPIFSNRGDFRGYCYVEFKEEKSALQALEMDRKSVEGRPMFVSPCVDKSKNPDFKVFRYSTSLEKHKLFISGLPFSCTKEELEEICKAHGTVKDLRLVTNRAGKPKGLAYVEYENESQASQAVMKMDGMTIKENIIKVAISNPPQRKVPEKPETRKAPGGPMLLPQTYGARGKGRTQLSLLPRALQRPSAAAPQAENGPAAAPAVAAPAATEAPKMSNADFAKLFLRK"},{"id":"SEQ_02459","a":"Q9BWX5","g":"GATA5","d":"Transcription factor GATA-5","L":397,"m":[{"c":"CxNCxxxoTxLWRR[DN][GS]xGxxψCNACGLYxKψxGVxRPLφ","u":39,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two highly conserved 39-aa zinc-finger-like domain repeats separated by a 15-aa basic linker, sharing 21 identical anchor positions including paired CxxC motifs (CxNC and CNAC), T.LWRR, GLY.K, and GV.RPLφ.","i":[[189,227,"CVNCGALSTPLWRRDGTGHYLCNACGLYHKMNGVNRPLV"],[243,281,"CTNCHTTNTTLWRRNSEGEPVCNACGLYMKLHGVPRPLA"]]}],"s":"MYQSLALAASPRQAAYADSGSFLHAPGAGSPMFVPPARVPSMLSYLSGCEPSPQPPELAARPGWAQTATADSSAFGPGSPHPPAAHPPGATAFPFAHSPSGPGSGGSAGGRDGSAYQGALLPREQFAAPLGRPVGTSYSATYPAYVSPDVAQSWTAGPFDGSVLHGLPGRRPTFVSDFLEEFPGEGRECVNCGALSTPLWRRDGTGHYLCNACGLYHKMNGVNRPLVRPQKRLSSSRRAGLCCTNCHTTNTTLWRRNSEGEPVCNACGLYMKLHGVPRPLAMKKESIQTRKRKPKTIAKARGSSGSTRNASASPSAVASTDSSAATSKAKPSLASPVCPGPSMAPQASGQEDDSLAPGHLEFKFEPEDFAFPSTAPSPQAGLRGALRQEAWCALALA"},{"id":"SEQ_02467","a":"Q5VV43","g":"KIAA0319","d":"Dyslexia-associated protein KIAA0319","L":1072,"m":[{"c":"P[PR](x){9,14}ψ[TIV][LF]P(x){19,21}Y[EHL]W(x){20,23}ψ[ST]xψxxGxYxFxψxV[STK][SD](x){7,8}[FTV]φxψxV(x){6,8}","u":"94-104","sp":"tandem","x":"structured_like","cf":"high","why":"Five head-to-tail tandem 94-104 aa beta-sandwich-like domain repeats (residues 329-815) anchored by N-terminal P[PR] and ψ[TIV][LF]P motifs, a central Y[EHL]W aromatic core, and C-terminal ψ[ST]xψxxGxYxFxψxV and [FTV]φxψxV signatures (with copies 2-5 additionally sharing an internal xS[AI]T[LI][DN]G[SN]xS[TS]DDxxIV[SLF] motif).","i":[[329,432,"PRTVKELTVSAGDNLIITLPDNEVELKAFVAPAPPVETTYNYEWNLISHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFVNVTVKPARRVNL"],[433,527,"PPVAVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEEKTSVDSPVLRLSNLDPGNYSFRLTVTDSDGATNSTTAALIVNNAVDY"],[528,623,"PPVANAGPNHTITLPQNSITLNGNQSSDDHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLKVTDSSRQQSTAVVTVIVQPENNR"],[624,717,"PPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHWEHVRGPSAVEMENIDKAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNS"],[718,815,"PPRARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTNLVEGVYTFHLRVTDSQGASDTDTATVEVQPDPRKS"]]}],"s":"MAPPTGVLSSLLLLVTIAGCARKQCSEGRTYSNAVISPNLETTRIMRVSHTFPVVDCTAACCDLSSCDLAWWFEGRCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMMLNRGSPSGIWGDSPEDIRKDLTFLGKDWGLEEMSEYSDDYRELEKDLLQPSGKQEPRGSAEYTDWGLLPGSEGAFNSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPTTPSSGEVLEKEKASQLQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGSTEHSIPTPPTSAAPSESTPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAPAPPVETTYNYEWNLISHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFVNVTVKPARRVNLPPVAVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEEKTSVDSPVLRLSNLDPGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTITLPQNSITLNGNQSSDDHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLKVTDSSRQQSTAVVTVIVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHWEHVRGPSAVEMENIDKAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPRARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTNLVEGVYTFHLRVTDSQGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQLAVLLNVLDSDIKVQKIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADFLLFKVLRVDTAGCLLKCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVTVLAFTLIVLTGGFTWLCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRSTEHNSSLMVSESEFDSDQDTIFSREKMERGNPKVSMNGSIRNGASFSYCSKDR"},{"id":"SEQ_02473","a":"Q92922","g":"SMARCC1","d":"SWI/SNF complex subunit SMARCC1","L":1105,"m":[{"c":"PGx[MH][MI]","u":5,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Three head-to-tail 5-aa repeats in the C-terminal P/G/M-rich disordered region (residues 1020-1034) anchored by an invariant N-terminal PG dipeptide, a central polar/basic position, [MH] at position 4, and large aliphatic [MI] at position 5.","i":[[1020,1024,"PGSMM"],[1025,1029,"PGQHM"],[1030,1034,"PGRMI"]]}],"s":"MAAAAGGGGPGTAVGATGSGIAAAAAGLAVYRRKDGGPATKFWESPETVSQLDSVRVWLGKHYKKYVHADAPTNKTLAGLVVQLLQFQEDAFGKHVTNPAFTKLPAKCFMDFKAGGALCHILGAAYKYKNEQGWRRFDLQNPSRMDRNVEMFMNIEKTLVQNNCLTRPNIYLIPDIDLKLANKLKDIIKRHQGTFTDEKSKASHHIYPYSSSQDDEEWLRPVMRKEKQVLVHWGFYPDSYDTWVHSNDVDAEIEDPPIPEKPWKVHVKWILDTDIFNEWMNEEDYEVDENRKPVSFRQRISTKNEEPVRSPERRDRKASANARKRKHSPSPPPPTPTESRKKSGKKGQASLYGKRRSQKEEDEQEDLTKDMEDPTPVPNIEEVVLPKNVNLKKDSENTPVKGGTVADLDEQDEETVTAGGKEDEDPAKGDQSRSVDLGEDNVTEQTNHIIIPSYASWFDYNCIHVIERRALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLTGDVCAVMRVHAFLEQWGLVNYQVDPESRPMAMGPPPTPHFNVLADTPSGLVPLHLRSPQVPAAQQMLNFPEKNKEKPVDLQNFGLRTDIYSKKTLAKSKGASAGREWTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIEDPYLENSDASLGPLAYQPVPFSQSGNPVMSTVAFLASVVDPRVASAAAKAALEEFSRVREEVPLELVEAHVKKVQEAARASGKVDPTYGLESSCIAGTGPDEPEKLEGAEEEKMEADPDGQQPEKAENKVENETDEGDKAQDGENEKNSEKEQDSEVSEDTKSEEKETEENKELTDTCKERESDTGKKKVEHEISEGNVATAAAAALASAATKAKHLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREKEALEQQRQQLLTERQNFHMEQLKYAELRARQQMEQQQHGQNPQQAHQHSGGPGLAPLGAAGHPGMMPHQQPPPYPLMHHQMPPPHPPQPGQIPGPGSMMPGQHMPGRMIPTVAANIHPSGSGPTPPGMPPMPGNILGPRVPLTAPNGMYPPPPQQQPPPPPPADGVPPPPAPGPPASAAP"},{"id":"SEQ_02491","a":"P0DV74","g":"FAM90A17","d":"Protein FAM90A17","L":464,"m":[{"c":"P[PQ]AA[ST](x){12,15}+[RT]PA[QV]x[PS]","u":"24-27","sp":"dispersed","x":"disordered_like","cf":"high","why":"Three bipartite disordered repeats (two nearly tandem 27-aa copies separated by 3 aa, followed by a 24-aa copy 36 aa downstream) pairing a conserved N-terminal P[PQ]AA[ST] motif with a C-terminal +[RT]PA[QV]x[PS] motif across a 12-15 aa linker.","i":[[241,267,"PQAASKTHGLLQAARPQAQDKRPAVTS"],[271,297,"PPAATHSLGLGSNLSFGPGAKRPAQAP"],[334,357,"PPAATELGPSTSPQMGRRTPAQVP"]]}],"s":"MMARRDPKSWAKRLVRAQTLQKQRRAPVGPRAPPPDEEDPRLKCKNCGAFGHTARSTRCPMKCWKAALVPATLGKKEGKENLKPWKPRVEANPGPLNKDKGEKEERPRQQDPQRKALLHMFSGKPPEKPLPNGKGSTESSDHLRVASGPMPVHTTSKRPRVDPVLADRSAAEMSGRGSVLASLSPLRKASLSSSSSLGPKERQTGAAADIPQPAVRHQGREPLLVVKPTHSRPEGGCREVPQAASKTHGLLQAARPQAQDKRPAVTSQPCPPAATHSLGLGSNLSFGPGAKRPAQAPIQACLNFPKKPRLGPFQIPESAIQGGELGAPENLQPPPAATELGPSTSPQMGRRTPAQVPSVDRQPPHSTPCLPTAQACTMSHHSAASHDGAQPLRVLFRRLENGRWSSSLLAAPSFHSPEKPGAFLAQSPHVSEKSEAPCVRVPPSVLYEDLQVSSSSEDSDSDLE"},{"id":"SEQ_02494","a":"O15213","g":"WDR46","d":"WD repeat-containing protein 46","L":610,"m":[{"c":"(x){13,17}ψx[FYV](x){3,6}xxxxxx(x){3,6}xxxφxxxx","u":"39-42","sp":"tandem","x":"structured_like","cf":"high","why":"Seven ~39-42 aa beta-propeller blades (residues 188-477; six consecutive zero-gap tandem copies and a seventh after an 8-aa loop) conserving hydrophobic beta-strand cores including ψx[FYV], a hydrophobic b-strand, GH/GD/GL-containing turns, and a c-strand ending in φ followed by aromatic/acidic residues.","i":[[188,226,"HFDLNLRQFGPYRLNYSRTGRHLAFGGRRGHVAALDWVT"],[227,265,"KKLMCEINVMEAVRDIRFLHSEALLAVAQNRWLHIYDNQ"],[266,305,"GIELHCIRRCDRVTRLEFLPFHFLLATASETGFLTYLDVS"],[306,347,"VGKIVAALNARAGRLDVMSQNPYNAVIHLGHSNGTVSLWSPA"],[348,389,"MKEPLAKILCHRGGVRAVAVDSTGTYMATSGLDHQLKIFDLR"],[390,429,"GTYQPLSTRTLPHGAGHLAFSQRGLLVAGMGDVVNIWAGQ"],[438,477,"EQPYLTHRLSGPVHGLQFCPFEDVLGVGHTGGITSMLVPG"]]}],"s":"METAPKPGKDVPPKKDKLQTKRKKPRRYWEEETVPTTAGASPGPPRNKKNRELRPQRPKNAYILKKSRISKKPQVPKKPREWKNPESQRGLSGTQDPFPGPAPVPVEVVQKFCRIDKSRKLPHSKAKTRSRLEVAEAEEEETSIKAARSELLLAEEPGFLEGEDGEDTAKICQADIVEAVDIASAAKHFDLNLRQFGPYRLNYSRTGRHLAFGGRRGHVAALDWVTKKLMCEINVMEAVRDIRFLHSEALLAVAQNRWLHIYDNQGIELHCIRRCDRVTRLEFLPFHFLLATASETGFLTYLDVSVGKIVAALNARAGRLDVMSQNPYNAVIHLGHSNGTVSLWSPAMKEPLAKILCHRGGVRAVAVDSTGTYMATSGLDHQLKIFDLRGTYQPLSTRTLPHGAGHLAFSQRGLLVAGMGDVVNIWAGQGKASPPSLEQPYLTHRLSGPVHGLQFCPFEDVLGVGHTGGITSMLVPGAGEPNFDGLESNPYRSRKQRQEWEVKALLEKVPAELICLDPRALAEVDVISLEQGKKEQIERLGYDPQAKAPFQPKPKQKGRSSTASLVKRKRKVMDEEHRDKVRQSLQQQHHKEAKAKPTGARPSALDRFVR"},{"id":"SEQ_02495","a":"P04626","g":"ERBB2","d":"Receptor tyrosine-protein kinase erbB-2","L":1255,"m":[{"c":"LxLRSLxEψxxGxφLIx[HR]NxxLCΩxxTψxWxxψF[HR]xxxQφφL(x){2,4}[AT]NR","u":"47-49","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of a 47-49 aa leucine-rich C-terminal cap module in the N-terminal half, anchored by 19 identical residues (including LRSL, G, LI, N, LC, T, W, F, Q, L, NR) and 10 physicochemically conserved hydrophobic/aromatic/basic positions across a single 2-4 aa variable loop.","i":[[140,188,"LQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNR"],[453,499,"LGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANR"]]},{"c":"[EP][NQ]PEY[LV]","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed copies of a conserved hexapeptide tyrosine motif in the proline/glycine-rich C-terminal disordered tail, anchored by an invariant PEY core flanked by polar [NQ] and aliphatic [LV] positions.","i":[[1135,1140,"PQPEYV"],[1192,1197,"ENPEYL"],[1244,1249,"ENPEYL"]]},{"c":"Cx[KP]C[HPS][IKP]xC","u":8,"sp":"dispersed","x":"structured_like","cf":"medium","why":"Four dispersed CxxCxxxC disulfide-knotted sub-motifs marking the N-terminal caps of cysteine-rich modules, sharing three invariant cysteines and strong proline/basic constraints at internal positions.","i":[[192,199,"CHPCSPMC"],[331,338,"CEKCSKPC"],[560,567,"CLPCHPEC"],[623,630,"CQPCPINC"]]}],"s":"MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV"},{"id":"SEQ_02506","a":"Q3B7T1","g":"EDRF1","d":"Erythroid differentiation-related factor 1","L":1238,"m":[{"c":"xxxφxx[AKM]Axψφxxφxxxxxxxxxxxxxxxxxxxx","u":34,"sp":"dispersed","x":"structured_like","cf":"high","why":"Nine 34-aa alpha-helical solenoid repeats across the C-terminal half (residues 696-1089) separated by short-to-moderate variable linkers (2-27 aa), anchored by an invariant Ala at position 8 (preceded by Ala in 7/9 copies) and conserved hydrophobic/aromatic packing positions at 4, 10, 11, and 14.","i":[[696,729,"YYVLSDAAMSLQKYGRALRYIKLALQSHDTYCCL"],[757,790,"QNANNRAAHLEEFHYQTKEDQEILHSLHRESSCQ"],[809,842,"SCKCYEAANEILQFSDLKSQNPEHYVQVLKRMGN"],[849,882,"VFYMNQAAALQSERLVSKSVSAAEQQLWKKSFSC"],[893,926,"IEDATNAALLLCNTGRLMRICAQAHCGAGDELKR"],[932,965,"EGLYYNKAIDYYLKALRSLGTRDIHPAVWDSVNW"],[968,1001,"STTYFTMATLQQDYAPLSRKAQEQIEKEVSEAMM"],[1017,1050,"PLCQYRAATIHHRLASMYHSCLRNQVGDEHLRKQ"],[1056,1089,"DLHYSKAAKLFQLLKDAPCELLRVQLERVAFAEF"]]}],"s":"MGDAKEAGAEGPPAGAAARGGLSLLSQGESEESSAQGSALFLGGNEVKSRAVVKYSSAPPRTAFARLEEKTDLKLPPANWLRESAKLGPAGTTILGNSKKSKPFSSFGMAYDFIDSVGNDVDVVSDSENIKKLLKIPYSKSHVSMAVHRIGRTLLLDELDIQELFMRSSQTGDWTWLKEFYQRLIDQKWQRKKKSKEHWYQKAILSKFLYYSINGDGAAQPVSSTAEQQESSSSDQTNDSEGASWPAPFEMPSSVSEDPSASSQGSEPLEPSYIVGHVASAPKEQNLITLFNDGEHSQGLKNDFVRNILWTFEDIHMLVGSNMPIFGGGRYPAVSLRLRDNNKPINVLTGIDYWLDNLICNVPELVMCFHVNGIVQKYEMIKTEEIPNLENSNFSTKVIKDIAQNILSFLKSNCTKEGHTYWLFKASGSDIVKLYDLTTLCEETEDKYQNPFTMPVAILLYKVACNMMMKKNQNKKHYGTIRTLLLNCLKLLDKSRHPQIIASANYMLSELFQLDEPKKEENSESPLNENSDESYSEEEEEMPDSDENGSYSTSSDPSDDSKAVAIIKSVGELSVPEKYKSIHQIRPSCAFPVCHDTEERCRLVLSYVLEGLKSVDSSIKKESDLPAADPSTPIPLKYEDESSRGGPEGLEKQMALFLDKMGSLQKGNYSSQSGMIPGSWQHKMKLQLILKSSKAYYVLSDAAMSLQKYGRALRYIKLALQSHDTYCCLCTNMLSEVLLFLSQYLTLCGDIQLMLAQNANNRAAHLEEFHYQTKEDQEILHSLHRESSCQGFAWATDLSTDLESQLSVSCKCYEAANEILQFSDLKSQNPEHYVQVLKRMGNIRNEIGVFYMNQAAALQSERLVSKSVSAAEQQLWKKSFSCFEKGIHNFESIEDATNAALLLCNTGRLMRICAQAHCGAGDELKREFSPEEGLYYNKAIDYYLKALRSLGTRDIHPAVWDSVNWELSTTYFTMATLQQDYAPLSRKAQEQIEKEVSEAMMKSLKYCDVDSVSARQPLCQYRAATIHHRLASMYHSCLRNQVGDEHLRKQHRVLADLHYSKAAKLFQLLKDAPCELLRVQLERVAFAEFQMTSQNSNVGKLKTLSGALDIMVRTEHAFQLIQKELIEEFGQPKSGDAAAAADASPSLNREEVMKLLSIFESRLSFLLLQSIKLLSSTKKKTSNNIEDDTILKTNKHIYSQLLRATANKTATLLERINVIVHLLGQLAAGSAASSNAVQ"},{"id":"SEQ_02511","a":"O14562","g":"UBFD1","d":"Ubiquitin domain-containing protein UBFD1","L":309,"m":[{"c":"ψWxxTK(x){3,4}K[FL]PψxS[TI](x){15,20}ψMφxxLxPx-","u":"42-46","sp":"dispersed","x":"structured_like","cf":"high","why":"Two duplicated structured domain cores (residues 91-136 and 238-279) separated by a central polar/charged linker, sharing 9 invariant anchor residues (W, T, K, K, P, S, M, L, P) and 7 physicochemically conserved positions across two aligned blocks connected by short variable loops.","i":[[91,136,"IWNKTKHDVKFPLDSTGSELKQKIHSITGLPPAMQKVMYKGLVPED"],[240,281,"LWIGTKERTEKLPMGSIKNVVSEPIEGHEDYHMMAFQLGPTE"]]}],"s":"MAAAGAPDGMEEPGMDTEAETVATEAPARPVNCLEAEAAAGAAAEDSGAARGSLQPAPAQPPGDPAAQASVSNGEDAGGGAGRELVDLKIIWNKTKHDVKFPLDSTGSELKQKIHSITGLPPAMQKVMYKGLVPEDKTLREIKVTSGAKIMVVGSTINDVLAVNTPKDAAQQDAKAEENKKEPLCRQKQHRKVLDKGKPEDVMPSVKGAQERLPTVPLSGMYNKSGGKVRLTFKLEQDQLWIGTKERTEKLPMGSIKNVVSEPIEGHEDYHMMAFQLGPTEASYYWVYWVPTQYVDAIKDTVLGKWQYF"},{"id":"SEQ_02512","a":"Q8IY17","g":"PNPLA6","d":"Patatin-like phospholipase domain-containing protein 6","L":1375,"m":[{"c":"P[LSF]φ(x){11,18}φ[GR]QGD(x){6,12}φVψx[DG]xL(x){10,11}[EDK]xxψxxφx[PR]G-[SL]ψ[GN](x){3,7}φψT[GR]x(x){0,2}P(x){2,3}Tψ(x){1,3}AxRD[SCT][TE]φφ+ψ[PS]xxxφxxψxxx[YQ]P[ESQ](x){0,3}[RV]Vxxφφ[MH]xxx[QA]+","u":"113-124","sp":"dispersed","x":"structured_like","cf":"high","why":"Three copies of a ~113-124 aa globular repeat domain (an N-terminal copy separated by ~185 aa from a tandem C-terminal pair) anchored by conserved P[LSF]φ, φ[GR]QGD, φVψx[DG]xL, [PR]G-[SL]ψ[GN], D[SCT][TE]φφ+ψ[PS], and [YQ]P[ESQ]...Vxxφφ[MH] motifs.","i":[[202,325,"PLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQR"],[521,633,"PSLLNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKAEDVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTVAAR"],[636,749,"PFVRQMDFAIDWTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKELVGEYGRGDLIGVVEALTRQPRATTVHAVRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQK"]]}],"s":"MEAPLQTGMMGTSSHGLATNSSGAKVAERDGFQDVLAPGEGSAGRICGAQPVPFVPQVLGVMIGAGVAVVVTAVLILLVVRRLRVPKTPAPDGPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVSATSRPRMRKKLKMLNIAKKILRIQKETPTLQRKEPPPAVLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTRTSPVRGSKRMVSTSATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLETPSAPLLSRCVSMPGDISGLQGGPRSDFDMAYERGRISVSLQEEASGGSLAAPARTPTQEPREQPAGACEYSYCEDESATGGCPFGPYQGRQTSSIFEAAKQELAKLMRIEDPSLLNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKAEDVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKELVGEYGRGDLIGVVEALTRQPRATTVHAVRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQKILGNLQQLQGPFPAGSGLGVPPHSELTNPASNLATVAILPVCAEVPMVAFTLELQHALQAIGPTLLLNSDIIRARLGASALDSIQEFRLSGWLAQQEDAHRIVLYQTDASLTPWTVRCLRQADCILIVGLGDQEPTLGQLEQMLENTAVRALKQLVLLHREEGAGPTRTVEWLNMRSWCSGHLHLRCPRRLFSRRSPAKLHELYEKVFSRRADRHSDFSRLARVLTGNTIALVLGGGGARGCSHIGVLKALEEAGVPVDLVGGTSIGSFIGALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYPVTSMFTGSAFNRSIHRVFQDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGYLPPLCDPKDGHLLMDGGYINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGWWLLWKRLNPWADKVKVPDMAEIQSRLAYVSCVRQLEVVKSSSYCEYLRPPIDCFKTMDFGKFDQIYDVGYQYGKAVFGGWSRGNVIEKMLTDRRSTDLNESRRADVLAFPSSGFTDLAEIVSRIEPPTSYVSDGCADGEESDCLTEYEEDAGPDCSRDEGGSPEGASPSTASEMEEEKSILRQRRCLPQEPPGSATDA"},{"id":"SEQ_02522","a":"P0C671","g":"BNIP5","d":"Protein BNIP5","L":652,"m":[{"c":"PA[LP](x){0,2}R++(x){3,4}++xS[RLF](x){5,8}KKH(x){7,29}G[EA]A[DG](x){2,3}P[EA](x){7,10}SFLx[KL][VC](x){1,2}G(x){26,56}[FI]IQ[KM]ψψ[ESA]ψL[KQ]x[VA][GED][DEG]Qx[EG][EQ](x){0,1}Q","u":"124-134","sp":"periodic","x":"mixed","cf":"high","why":"Three large internal repeats separated by regular 12-aa linkers, combining a basic/proline-rich disordered-like N-terminal region (anchored by PA[LP], R++, KKH, G[EA]A[DG], and SFL motifs, with copies 2 and 3 sharing near-identical SFLPLCV[SG]GHRPS[IT]SSS cores) and a conserved C-terminal amphipathic helix ([FI]IQ[KM]ψψ[ESA]ψL...Q).","i":[[142,265,"PALRKKAHHDKKPSRKKQGHKKHAAEVTKAAQDQEARGREEGLSKAAAALRSGEADLGPARRGGEDSDHQSFLIKVDGTGALDVSPHATGHQQEEELKKPDQDAIIQMIVELLKRVGDQWEEEQ"],[278,411,"PAPAVRKKSQEKKTSLKRTSKTNPKKHGSEEAKRGAADVSSPEAWPPKKSSFLPLCVSGHRPSISSSYGLEEPKVQEAPSTEAGAPGPSVLPTPSESQEPGEELPLDRASEYKEFIQKIISMLQDAEEQQGEEQ"],[424,556,"PAPHCRRKSQEKRSSFRRAFYHKKHTSKEPRRAGAAGAASPEARRPKRPSFLPLCVGGHRPSTSSSLDPEDLECREPLPAEGEPVVISEAPSQARGHTPEGAPQLSGACESKEIIIQKLVALLQEVDGQLGQQ"]]}],"s":"MENPRCPRRPLAEKKARSLDRPQAPGKGSESWDCHWLSLPTAPSRKALHWTTSDWARHSDSPAPSAEAHCTTAAAPTPEETGDFLPSEQRPSQDTKKGWLKTMLNFFVRTGPEEPREKASRRPRGKEGISQHPEPLEAAGEPALRKKAHHDKKPSRKKQGHKKHAAEVTKAAQDQEARGREEGLSKAAAALRSGEADLGPARRGGEDSDHQSFLIKVDGTGALDVSPHATGHQQEEELKKPDQDAIIQMIVELLKRVGDQWEEEQSLASQLGVALPNPAPAVRKKSQEKKTSLKRTSKTNPKKHGSEEAKRGAADVSSPEAWPPKKSSFLPLCVSGHRPSISSSYGLEEPKVQEAPSTEAGAPGPSVLPTPSESQEPGEELPLDRASEYKEFIQKIISMLQDAEEQQGEEQPQVQQEEVGVENPAPHCRRKSQEKRSSFRRAFYHKKHTSKEPRRAGAAGAASPEARRPKRPSFLPLCVGGHRPSTSSSLDPEDLECREPLPAEGEPVVISEAPSQARGHTPEGAPQLSGACESKEIIIQKLVALLQEVDGQLGQQIRRHPSFKRFFYEFSDSSLSKLVATLRSQVAHSSKLDRNRARRLYQFDVSLANKFAGSNSHAMCILMGLRDHYNCTQFPYREDQPNITSPKVESPD"},{"id":"SEQ_02573","a":"Q5JRM2","g":"CXorf66","d":"Uncharacterized protein CXorf66","L":361,"m":[{"c":"P[PS][QK]xFxP","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three clustered 7-residue proline-rich motif copies within a 37-aa disordered segment share fixed P1, rare aromatic F5, and P7 anchors alongside constrained [PS]2 and polar/basic [QK]3 positions.","i":[[209,215,"PPQLFKP"],[227,233,"PSKPFGP"],[239,245,"PPKHFNP"]]}],"s":"MNLVICVLLLSIWKNNCMTTNQTNGSSTTGDKPVESMQTKLNYLRRNLLILVGIIIMVFVFICFCYLHYNCLSDDASKAGMVKKKGIAAKSSKTSFSEAKTASQCSPETQPMLSTADKSSDSSSPERASAQSSTEKLIRPSSLQKPSIPNSAGKLTRPSYPKRSSKSSCSKKLSKSSHLEKAHKKGSLEKLCKLDYACKLASSDKPVRPPQLFKPLYSSHPQNEISPSKPFGPQELAKPPKHFNPKRSVSLGRAALLSNSELAETCQPYKKKHLVAKTYRPLVNDISEAKEKNTQNLHVSSKVKSSSRSFRKLDSRNNAYGDHVNDSDTMKYYSEVDSDKVIIITCDRGYNQVTSEVTLND"},{"id":"SEQ_02575","a":"Q9UN75","g":"PCDHA12","d":"Protocadherin alpha-12","L":941,"m":[{"c":"(x){15,25}φxxxx[AV]xDx[DG]xxx[NA]xxψxx(x){25,30}ψDx[EA](x){26,27}ψxψx-(x){0,1}N[DG]oxPxx","u":"105-113","sp":"tandem","x":"structured_like","cf":"high","why":"Six head-to-tail tandem ~105-113 aa structured domain repeats share conserved Dx[DG]xxx[NA]xxψ, ψDx[EA], and C-terminal ψxψx-(x){0,1}N[DG]oxPxx linker/calcium-binding signature motifs.","i":[[29,133,"GQLHYSVYEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDREKLCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVF"],[134,242,"REREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNENFELKIKTKKDKSILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAF"],[243,350,"DKPSYKVVLSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILPVSEKCMFSINPDTGEIRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEV"],[351,455,"MVTSLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAF"],[456,565,"AQPEYTVFVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL"],[566,678,"LATPAGSAGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAVGAHIPFHVGLYTGEISTTRILDEADAPRHRLLVLVKDHGEPALTSTATVLVSLVENGQAPKT"]]}],"s":"MVIIGPRGPGSQRLLLSLLLLAAWEVGSGQLHYSVYEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDREKLCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNENFELKIKTKKDKSILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYKVVLSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILPVSEKCMFSINPDTGEIRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAVGAHIPFHVGLYTGEISTTRILDEADAPRHRLLVLVKDHGEPALTSTATVLVSLVENGQAPKTSSRASVGAVDPEAALVDINVYLIIAICAVSSLLVLTLLLYTALRCSAPPTVSRCAPGKPTLVCSSAVGSWSYSQQRRQRVCSAESPPKTDLMAFSPSLQLSREDCLNPPSEPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ"},{"id":"SEQ_02580","a":"A6NI47","g":"POTEM","d":"Putative POTE ankyrin domain family member M","L":508,"m":[{"c":"LRSKMGKWC[RC]HCFP[WC]CRGSGKS[NK]VG[TP][SW]GD[HY]DDSA[MF][KM][TE]","u":37,"sp":"tandem","x":"mixed","cf":"high","why":"Three highly conserved head-to-tail tandem 37-aa repeats at the N-terminus (including two 100% identical copies) combine a cysteine/tryptophan-rich WCRHCFPWCR core with a conserved GSGKSxVGxxGDxDDSA tail.","i":[[20,56,"LRSKMGKWCRHCFPWCRGSGKSNVGTSGDHDDSAMKT"],[57,93,"LRSKMGKWCRHCFPWCRGSGKSNVGTSGDHDDSAMKT"],[94,130,"LRSKMGKWCCHCFPCCRGSGKSKVGPWGDYDDSAFME"]]},{"c":"x[GK]xT[APV]xxx[AG]xxxxxxxxxxφLxxxxxxxxxxxx","u":33,"sp":"tandem","x":"structured_like","cf":"high","why":"Six contiguous 33-aa tandem structured repeats share conserved [GK]2, fixed T4, [APV]5, [AG]9, and a hydrophobic φ20-L21 helical core.","i":[[172,204,"QKRTALHLASANGNSEVVKLLLDRRCQLNILDN"],[205,237,"KKRTALTKAVQCQEDECALMLLEHGTDPNIPDE"],[238,270,"YGNTALHYAIYNEDKLMAKALLLYGADIESKNK"],[271,303,"HGLTPLLLGVHEQKQQVVKFLIKKKANLNALDR"],[304,336,"YGRTVLILAVCCGSASIVSLLLEQNIDVSSQDL"],[337,369,"SGQTAREYAVSSRHNVICQLLSDYKEKQILKVS"]]}],"s":"MVAEAGSMPAASSVKKPFGLRSKMGKWCRHCFPWCRGSGKSNVGTSGDHDDSAMKTLRSKMGKWCRHCFPWCRGSGKSNVGTSGDHDDSAMKTLRSKMGKWCCHCFPCCRGSGKSKVGPWGDYDDSAFMEPRYHVRREDLDKLHRAAWWGKVPRKDLIVMLKDTDMNKKDKQKRTALHLASANGNSEVVKLLLDRRCQLNILDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTALHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTVLILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSRHNVICQLLSDYKEKQILKVSSENSNPEQDLKLTSEEESQRLKGSENSQPEEMSQEPEINKGGDRKVEEEMKKHGSTHMGFPENLPNGATADNGDDGLIPPRKSRTPESQQFPDTENEQYHSDEQNDTQKQLSEEQNTGILQDEILIHEEKQIEVAENEF"},{"id":"SEQ_02586","a":"Q8NAG6","g":"ANKLE1","d":"Structure-specific endonuclease ANKLE1","L":615,"m":[{"c":"[AG]ψ[ER](x){0,3}xLL[RS][CQ]G[AG]DP[NA]φ[RV]xx-[GA]φx[PA]ψ[HD]ψAφxx[GR][HC]x[RE]","u":"33-36","sp":"tandem","x":"structured_like","cf":"high","why":"Three head-to-tail tandem 33-36 aa structural repeats near the N-terminus (residues 22-123, with a 3-residue loop insertion in copy 2) anchored by conserved LLxxG[AG]DP[NA] and [PA]ψ[HD]ψAφ helix-turn-helix motifs.","i":[[22,54,"AVEELLRCGADPNLVLEDGAAAVHLAAGARHPR"],[55,90,"GLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRR"],[91,123,"GLELLLSQGADPALRDQDGLRPLDLALQQGHLE"]]}],"s":"MCSEARLARRLRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIGAETQEPEPAPGTPGLSGPTDETLDSIALQKQPCRGDNRDIGLEADPGPPSLPVPLETVDKHGSSASPPGHWDYSSDASFVTAVEVSGAEDPASDTPPWAGSLPPTRQGLLHVVHANQRVPRSQGTEAELNARLQALTLTPPNAAGFQSSPSSMPLLDRSPAHSPPRTPTPGASDCHCLWEHQTSIDSDMATLWLTEDEASSTGGREPVGPCRHLPVSTVSDLELLKGLRALGENPHPITPFTRQLYHQQLEEAQIAPGPEFSGHSLELAAALRTGCIPDVQADEDALAQQFEQPDPARRWREGVVKSSFTYLLLDPRETQDLPARAFSLTPAERLQTFIRAIFYVGKGTRARPYVHLWEALGHHGRSRKQPHQACPKVRQILDIWASGCGVVSLHCFQHVVAVEAYTREACIVEALGIQTLTNQKQGHCYGVVAGWPPARRRRLGVHLLHRALLVFLAEGERQLHPQDIQARG"},{"id":"SEQ_02592","a":"Q99704","g":"DOK1","d":"Docking protein 1","L":481,"m":[{"c":"xYxxP","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Six dispersed 5-aa tyrosine-proline motifs clustered in three pairs across the disordered C-terminal tail (residues 295-412), anchored by invariant Y and P with constrained flanking chemistry ([LI] at position 1 in 4/6 copies, small polar/acidic [ASDE] at position 3, and acidic/aliphatic [EDLV] at position 4).","i":[[295,299,"LYAEP"],[314,318,"LYSDP"],[361,365,"IYDEP"],[376,380,"LYDLP"],[397,401,"GYELP"],[408,412,"DYAVP"]]}],"s":"MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGSSRRLDCKVIRLAECVSVAPVTVETPPEPGATAFRLDTAQRSHLLAADAPSSAAWVQTLCRNAFPKGSWTLAPTDNPPKLSALEMLENSLYSPTWEGSQFWVTVQRTEAAERCGLHGSYVLRVEAERLTLLTVGAQSQILEPLLSWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVETAIHRQKAQGKAGQGHDVLRADSHEGEVAEGKLPSPPGPQELLDSPPALYAEPLDSLRIAPCPSQDSLYSDPLDSTSAQAGEGVQRKKPLYWDLYEHAQQQLLKAKLTDPKEDPIYDEPEGLAPVPPQGLYDLPREPKDAWWCQARVKEEGYELPYNPATDDYAVPPPRSTKPLLAPKPQGPAFPEPGTATGSGIKSHNSALYSQVQKSGASGSWDCGLSRVGTDKTGVKSEGST"},{"id":"SEQ_02603","a":"Q5H9L2","g":"TCEAL5","d":"Transcription elongation factor A protein-like 5","L":206,"m":[{"c":"[EQ]GKP-x","u":6,"sp":"tandem","x":"disordered_like","cf":"high","why":"Fifteen head-to-tail 6-residue repeats spanning the disordered N-terminal region (residues 9-98), anchored by an invariant N-terminal [EQ], predominant G-K-P core, and conserved acidic position 5.","i":[[9,14,"EGKPEN"],[15,20,"ERNLES"],[21,26,"EGKPED"],[27,32,"EGSTED"],[33,38,"EGKSDE"],[39,44,"EEKPDM"],[45,50,"EGKTEC"],[51,56,"EGKRED"],[57,62,"EGEPGD"],[63,68,"EGQLED"],[69,74,"EGNQEK"],[75,80,"QGKSEG"],[81,86,"EDKPQS"],[87,92,"EGKPAS"],[93,98,"QAKPES"]]}],"s":"MEKLYKENEGKPENERNLESEGKPEDEGSTEDEGKSDEEEKPDMEGKTECEGKREDEGEPGDEGQLEDEGNQEKQGKSEGEDKPQSEGKPASQAKPESQPRAAEKRPAEDYVPRKAKRKTDRGTDDSPKDSQEDLQERHLSSEEMMRECGDVSRAQEELRKKQKMGGFHWMQRDVQDPFAPRGQRGVRGVRGGGRGQKDLEDVPYV"},{"id":"SEQ_02615","a":"Q7Z5R6","g":"APBB1IP","d":"Amyloid beta A4 precursor protein-binding family B member 1-interacting protein","L":666,"m":[{"c":"[DPS][FDE]ψ[PE]PPP","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Six non-overlapping 7-residue repeats across proline-rich disordered segments (one at residues 126-132 and five clustered in the C-terminal tail across residues 552-602) share a conserved N-terminal acidic/phenylalanine and large-aliphatic anchor ([DPS][FDE]ψ) immediately preceding a [PE]PPP polyproline core.","i":[[126,132,"DDLPPPP"],[552,558,"DFLPPPP"],[566,572,"PELPPPP"],[574,580,"DFMEPPP"],[581,587,"DFVPPPP"],[596,602,"SELPPPP"]]}],"s":"MGESSEDIDQMFSTLLGEMDLLTQSLGVDTLPPPDPNPPRAEFNYSVGFKDLNESLNALEDQDLDALMADLVADISEAEQRTIQAQKESLQNQHHSASLQASIFSGAASLGYGTNVAATGISQYEDDLPPPPADPVLDLPLPPPPPEPLSQEEEEAQAKADKIKLALEKLKEAKVKKLVVKVHMNDNSTKSLMVDERQLARDVLDNLFEKTHCDCNVDWCLYEIYPELQIERFFEDHENVVEVLSDWTRDTENKILFLEKEEKYAVFKNPQNFYLDNRGKKESKETNEKMNAKNKESLLEESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLLRASGIYYVPKGKTKTSRDLACFIQFENVNIYYGTQHKMKYKAPTDYCFVLKHPQIQKESQYIKYLCCDDTRTLNQWVMGIRIAKYGKTLYDNYQRAVAKAGLASRWTNLGTVNAAAPAQPSTGPKTGTTQPNGQIPQATHSVSAVLQEAQRHAETSKDKKPALGNHHDPAVPRAPHAPKSSLPPPPPVRRSSDTSGSPATPLKAKGTGGGGLPAPPDDFLPPPPPPPPLDDPELPPPPPDFMEPPPDFVPPPPPSYAGIAGSELPPPPPPPPAPAPAPVPDSARPPPAVAKRPPVPPKRQENPGHPGGAGGGEQDFMSDLMKALQKKRGNVS"},{"id":"SEQ_02624","a":"A4D1F6","g":"LRRD1","d":"Leucine-rich repeat and death domain-containing protein 1","L":860,"m":[{"c":"xψxx[LI]xφxxNxφ(x){2,5}φP(x){2,3}φxxφx","u":"23-26","sp":"tandem","x":"structured_like","cf":"high","why":"Contiguous 24-copy head-to-tail tandem array of predominantly 23-residue structured units anchored by periodic aliphatic/hydrophobic positions, an invariant-like central N anchor (xψxx[LI]xφxxNxφ), and a conserved C-terminal φPxxφxxφx segment.","i":[[165,188,"YVKYLYLDKNQIKTFQGADSGDLL"],[189,211,"GLEILSLQENGLSSLPSEIQLLH"],[212,234,"NLRILNVSHNHISHIPKEISQLG"],[235,257,"NIRQLFFYNNYIENFPSDLECLG"],[258,280,"NLEILSLGKNKLRHIPDTLPSLK"],[281,303,"TLRVLNLEYNQLTTFPKALCFLP"],[304,326,"KLISLDLTGNLISSLPKEIRELK"],[327,349,"NLETLLMDHNKLTFLAVEIFQLL"],[350,372,"KIKELQLADNKLEVISHKIENFR"],[373,395,"ELRILILDKNLLKNIPEKISCCA"],[396,418,"MLECLSLSDNKLTELPKYIHKLN"],[419,441,"NLRKLHVNRNNMVKITDCISHLN"],[442,464,"NICSLEFSGNIITDVPIEIKNCQ"],[465,487,"KIIKIELSYNKIMYFPLGLCALD"],[488,510,"SLYYLSVNGNYISEIPVDISFSK"],[511,533,"QLLHLELSENKLLIFSEHFCSLI"],[534,556,"NLKYLDLGKNQIKKIPASISNMI"],[557,579,"SLHVLILCCNKFETFPRELCTLE"],[580,602,"NLQVLDLSENQLQKISSDICNLK"],[603,625,"GIQKLNFSSNQFIHFPIELCQLQ"],[626,651,"SLEQLNISQIKGRKLTRLPGELSNMT"],[652,674,"QLKELDISNNAIREIPRNIGELR"],[675,697,"NLVSLHAYNNQISYLPPSLLSLN"],[698,720,"DLQQLNLSGNNLTALPSAIYNIF"]]}],"s":"MSEKEGMSEVLEDTISQFRKESRSQSMKEPGFIKETSNLINEASDYLEGKSSNQIYETHPRQNTLESTSSSGRKSKRNEEQKKNLQFSETSTRTGTSQSLSSLTGRTAEYQALVNFLSHETVGEVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADERDEKILEKIFKIVANNITETNFEFLCQKLNLANSETDMPTKSTVSLSERAHQALVIWKTQSNKLSLTAAALRDQLIRALTMIGAYEIMDKITALNLFTRAIKF"},{"id":"SEQ_02639","a":"O60309","g":"LRRC37A3","d":"Leucine-rich repeat-containing protein 37A3","L":1634,"m":[{"c":"[TS][VT][QK][PL][LPA]D[LV][GEQ]φ[TA]I[TAI]x[EK][PS][TMS][TNA]E[VT][EGK]xS","u":22,"sp":"dispersed","x":"mixed","cf":"high","why":"Seven non-overlapping 22-residue repeats distributed across the central stalk/linker region with strictly invariant D6, I11, E18, and S22 anchors and tightly conserved hydrophobic/polar positions ([PL][LPA]D[LV]xφ[TA]I).","i":[[298,319,"TVKPADVEVTITSEPTNETESS"],[411,432,"SVKPPDVQLTIAAEPSAEVGTS"],[543,564,"TVQPLDLGFTITPESMTEVELS"],[607,628,"TVQLLDLGLTITPEPTTEVGHS"],[662,683,"TVQPLDLGFTITPKSMTEVEPS"],[717,738,"TVQPLDLELTITTKPTTEVKPS"],[745,766,"STQLPDLGLAIIPEPTTETGHS"]]},{"c":"xxx[LI]x[LF]xxNx[IL]o(x){12,15}","u":"24-27","sp":"tandem","x":"structured_like","cf":"high","why":"Five head-to-tail 24-27 aa structured repeats (flanked by cysteine-rich caps and followed by a sixth degenerate C-terminal unit) anchored by the canonical [LI]x[LF]xxNx[IL]o core and a conserved C-terminal aromatic spine.","i":[[867,890,"FTILNFQGNYISYIDGNVWKAYSW"],[891,914,"TEKLILRENNLTELHKDSFEGLLS"],[915,938,"LQYLDLSCNKIQSIERHTFEPLPF"],[939,965,"LKFINLSCNVITELSFGTFQAWHGMQF"],[966,989,"LHKLILNHNPLTTVEDPYLFKLPA"]]},{"c":"[QH]QE[AT]P[AIG][QLE]xP","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Six non-overlapping 9-mer motifs dispersed through the N-terminal P/S/E/Q-rich disordered region (distinct from the 22-aa repeats), anchored by invariant Q2, E3, P5, and P9 positions.","i":[[239,247,"QQEAPAQLP"],[258,266,"QQEAPALPP"],[322,330,"QQETPIQFP"],[339,347,"QQEAPIEPP"],[379,387,"QQETPGQPP"],[515,523,"HQEAPAQTP"]]}],"s":"MTSAQCPALACVMSPLRFWGPWPLLMWQLLWLLVKEAQPLEWVKDPLQLTSNPLGPPEPWSSHSSHFPRESPHAPTLPADPWDFDHLGPSASSEMPAPPQESTENLVPFLDTWDSAGELPLEPEQFLASQQDLKDKLSPQERLPVSPKKLKKDPAQRWSLAEIIGIIHQLSTPQSQKQTLQNEYSSTDTPYPGSLPPELRVKSDEPPGPSEQVGPSQFHLEPETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPSSMQQEAPALPPESSMESLTLPNHEVSVQPPGEDQAYYHLPNITVKPADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHELSISEQQQPVQPSESSREVESSPTQQETPGQPPEHHEVTVSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEVGTSLVHQEATTRLSGSGNDVEPPAIQHGGPPLLPESSEEAGPLAVQQETSFQSPEPINNENPSPTQQEAAAEHPQTAEEGESSLTHQEAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLGFTITPESMTEVELSPTMKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHSTPPKRTIVSPKHPEVTLPHPDQVQTQHSHLTRATVQPLDLGFTITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSPTTEETSTQLPDLGLAIIPEPTTETGHSTALEKTTAPRPDRVQTLHRSLTEVTGPPTELEPAQDSLVQSESYTQNKALTAPEEHKASTSTNICELCTCGDEMLSCIDLNPEQRLRQVPVPEPNTHNGTFTILNFQGNYISYIDGNVWKAYSWTEKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVITELSFGTFQAWHGMQFLHKLILNHNPLTTVEDPYLFKLPALKYLDMGTTLVPLTTLKNILMMTVELEKLIVPSHMACCLCQFKNSIEAVCKTVKLHCNSACLTNTTHCPEEASVGNPEGAFMKVLQARKNYTSTELIIEPEEPSDSSGINLSGFGSEQLDTNDESDVTSTLSYILPYFSAVNLDVKSLLLPFIKLPTTGNSLAKIQTVGKNRQRLNRVLMGPRSIQKRHFKEVGRQSIRREQGAQASVENTAEEKRLGSPAPRELKQPHTQQGPEKLAGNAVYTKPSFTQEHKAAVSVLKPFSKGAPSTSSPAKALPQVRDRWKDLTHAISILESAKARVTNMKTSKPIVHSRKKYRFHKTRSRMTHRTPKVKKSPKVRKKSYLSRLMLSNRLPFSAAKSLINSPSQGAFSSLRDLSPQENPFLEVSAPSEHFIENNNTKDTTARNAFEENVFMENTNMPEGTISENTNYNHPPEADSAGTAFNLGPTVKQTETKWEYNNVGTDLSPEPKSFNYPLLSSPGDQFEIQLTQQLQSVIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLVSRTGHLMKLLSGQQEVKASKIEWDTDQWKTENYINESTEAQSEQKEKSLEFTKELPGYGYTKKLILALIVTGILTILIILLCLIEICCHRRSLQEDEEGFSRDSEAPTEEESEALP"},{"id":"SEQ_02642","a":"P33240","g":"CSTF2","d":"Cleavage stimulation factor subunit 2","L":577,"m":[{"c":"-[AV]R[AG][ML]","u":5,"sp":"tandem","x":"mixed","cf":"high","why":"Eleven contiguous head-to-tail 5-aa repeats embedded between Pro/Gly-rich segments, showing an invariant central R3 anchor flanked by acidic ([DE]), small ([AV]/[AG]), and large aliphatic ([ML]) positions.","i":[[411,415,"DARGM"],[416,420,"EARAM"],[421,425,"EARGL"],[426,430,"DARGL"],[431,435,"EARAM"],[436,440,"EARAM"],[441,445,"EARAM"],[446,450,"EARAM"],[451,455,"EARAM"],[456,460,"EVRGM"],[461,465,"EARGM"]]}],"s":"MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETISPEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTNIPTLIAGNPQPVHGAGPGSGSNVSMNQQNPQAPQAQSLGGMHVNGAPPLMQASMQGGVPAPGQMPAAVTGPGPGSLAPGGGMQAQVGMPGSGPVSMERGQVPMQDPRAAMQRGSLPANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHVPGHESRGPPPHELRGGPLPEPRPLMAEPRGPMLDQRGPPLDGRGGRDPRGIDARGMEARAMEARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARGMDTRGPVPGPRGPIPSGMQGPSPINMGAVVPQGSRQVPVMQGTGMQGASIQGGSQPGGFSPGQNQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP"},{"id":"SEQ_02644","a":"Q9ULM3","g":"YEATS2","d":"YEATS domain-containing protein 2","L":1422,"m":[{"c":"[AS]FQPI[AT]xSCKIV","u":12,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Closely spaced 2-copy duplication (separated by a 13-aa P/S/Q-rich linker) within the central disordered region sharing 9/12 exact identities (FQPI and SCKIV blocks including conserved F, P, C, K, and aliphatic I/V anchors) plus conservative [AS] and [AT] positions.","i":[[426,437,"AFQPIASSCKIV"],[451,462,"SFQPITMSCKIV"]]}],"s":"MSGIKRTIKETDPDYEDVSVALPNKRHKAIENSARDAAVQKIETIIKEQFALEMKNKEHEIEVIDQRLIEARRMMDKLRACIVANYYASAGLLKVSEGSKTCDTMVFNHPAIKKFLESPSRSSSPANQRAETPSANHSESDSLSQHNDFLSDKDNNSNMDIEERLSNNMEQRPSRNTGRDTSRITGSHKTEQRNADLTDETSRLFVKKTIVVGNVSKYIPPDKREENDQSTHKWMVYVRGSRREPSINHFVKKVWFFLHPSYKPNDLVEVREPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHRHSLGEDCIYPQSSESDISDAPPSLPLTIPAPVKASSPIKQSHEPVPDTSVEKGFPASTEAERHTPFYALPSSLERTPTKMTTSQKVTFCSHGNSAFQPIASSCKIVPQSQVPNPESPGKSFQPITMSCKIVSGSPISTPSPSPLPRTPTSTPVHVKQGTAGSVINNPYVIMDKQPGQVIGATTPSTGSPTNKISTASQVSQGTGSPVPKIHGSSFVTSTVKQEDSLFASMPPLCPIGSHPKVQSPKPITGGLGAFTKVIIKQEPGEAPHVPATGAASQSPLPQYVTVKGGHMIAVSPQKQVITPGEGIAQSAKVQPSKVVGVPVGSALPSTVKQAVAISGGQILVAKASSSVSKAVGPKQVVTQGVAKAIVSGGGGTIVAQPVQTLTKAQVTAAGPQKSGSQGSVMATLQLPATNLANLANLPPGTKLYLTTNSKNPSGKGKLLLIPQGAILRATNNANLQSGSAASGGSGAGGGGGGGGGGGSGSGGGGSTGGGGGTAGGGTQSTAGPGGISQHLTYTSYILKQTPQGTFLVGQPSPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLKVISGQKTTLFTQAAHGGQASLMKISDSTLKTVPATSQLSKPGTTMLRVAGGVITTATSPAVALSANGPAQQSEGMAPVSSSTVSSVTKTSGQQQVCVSQATVGTCKAATPTVVSATSLVPTPNPISGKATVSGLLKIHSSQSSPQQAVLTIPSQLKPLSVNTSGGVQTILMPVNKVVQSFSTSKPPAILPVAAPTPVVPSSAPAAVAKVKTEPETPGPSCLSQEGQTAVKTEESSELGNYVIKIDHLETIQQLLTAVVKKIPLITAKSEDASCFSAKSVEQYYGWNIGKRRAAEWQRAMTMRKVLQEILEKNPRFHHLTPLKTKHIAHWCRCHGYTPPDPESLRNDGDSIEDVLTQIDSEPECPSSFSSADNLCRKLEDLQQFQKREPENEEEVDILSLSEPVKINIKKEQEEKQEEVKFYLPPTPGSEFIGDVTQKIGITLQPVALHRNVYASVVEDMILKATEQLVNDILRQALAVGYQTASHNRIPKEITVSNIHQAICNIPFLDFLTNKHMGILNEDQ"},{"id":"SEQ_02646","a":"Q99946","g":"PRRT1","d":"Proline-rich transmembrane protein 1","L":306,"m":[{"c":"ATLPR","u":5,"sp":"periodic","x":"disordered_like","cf":"high","why":"Three identical copies of the anchored pentapeptide ATLPR (fixed A, polar T, aliphatic L, P, and basic R) in the P/A/S/G-rich N-terminal disordered region, separated by regular 20-aa and 18-aa linkers.","i":[[54,58,"ATLPR"],[79,83,"ATLPR"],[102,106,"ATLPR"]]}],"s":"MSSEKSGLPDSVPHTSPPPYNAPQPPAEPPAPPPQAAPSSHHHHHHHYHQSGTATLPRLGAGGLASSAATAQRGPSSSATLPRPPHHAPPGPAAGAPPPGCATLPRMPPDPYLQETRFEGPLPPPPPAAAAPPPPAPAQTAQAPGFVVPTHAGTVGTLPLGGYVAPGYPLQLQPCTAYVPVYPVGTPYAGGTPGGTGVTSTLPPPPQGPGLALLEPRRPPHDYMPIAVLTTICCFWPTGIIAIFKAVQVRTALARGDMVSAEIASREARNFSFISLAVGIAAMVLCTILTVVIIIAAQHHENYWDP"},{"id":"SEQ_02657","a":"Q3SY56","g":"SP6","d":"Transcription factor Sp6","L":376,"m":[{"c":"C(x){2,4}C[GS]+xΩx+[ST][SD][HE]LxxH[LM]xxH","u":"21-23","sp":"periodic","x":"structured_like","cf":"high","why":"Three C2H2-type repeats separated by regular 7-aa linkers (SGDRPFV, TGTKKFP), anchored by invariant C-x(2,4)-C and H-[LM]-x-x-H coordination motifs plus conserved aromatic (Ω), basic (+), and L positions.","i":[[256,278,"CHIPGCGKAYAKTSHLKAHLRWH"],[286,308,"CNWLFCGKRFTRSDELQRHLQTH"],[316,336,"CAVCSRVFMRSDHLAKHMKTH"]]},{"c":"SWφ[DR][LP]x[HP]x","u":8,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Clustered 3-copy motif in the N-terminal proline/serine-rich disordered region anchored by an invariant SW dipeptide, bulky hydrophobic residue (F/W/M), [DR][LP] core, and adjacent H/P pair separated by 5-aa and 1-aa linkers.","i":[[106,113,"SWFRPTHP"],[119,126,"SWWDLHPG"],[128,135,"SWMDLPHT"]]}],"s":"MLTAVCGSLGSQHTEAPHASPPRLDLQPLQTYQGHTSPEAGDYPSPLQPGELQSLPLGPEVDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQPDMSHHYESWFRPTHPGAEDGSWWDLHPGTSWMDLPHTQGALTSPGHPGALQAGLGGYVGDHQLCAPPPHPHAHHLLPAAGGQHLLGPPDGAKALEVAAPESQGLDSSLDGAARPKGSRRSVPRSSGQTVCRCPNCLEAERLGAPCGPDGGKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMKTHEGAKEEAAGAASGEGKAGGAVEPPGGKGKREAEGSVAPSN"},{"id":"SEQ_02676","a":"Q96P47","g":"AGAP3","d":"Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3","L":875,"m":[{"c":"Gx[QT]xLxφ(x){10,11}ψL[LI]x[HY]G","u":"23-24","sp":"periodic","x":"structured_like","cf":"high","why":"Three consecutive 23-24 aa structured repeat cores in the C-terminal region (residues 750-842) separated by 9-13 aa linkers, each anchored by invariant terminal G residues, an N-terminal Gx[QT]xLxφ motif, and a conserved C-terminal ψL[LI]x[HY]G hydrophobic/aliphatic block.","i":[[750,772,"GQQLLRAVVEDDLRLLVMLLAHG"],[786,809,"GRTALHLSSAMANVVFTQLLIWYG"],[819,842,"GLTPLAYARRAGSQECADILIQHG"]]}],"s":"MNFQAGGGQSPQQQQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLIERIEDLALQNQIREHVISIEDSFVNSQEWTLSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAISAANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPCKSLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASSTPTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSPRANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSADQWSEATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSATEEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNAALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNREPANGTNPSAELHRSPSLL"},{"id":"SEQ_02681","a":"O43561","g":"LAT","d":"Linker for activation of T-cells family member 1","L":262,"m":[{"c":"-Y[VE]N[VL]","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed copies of a 5-residue tyrosine motif (-Y[VE]N[VL]) in the C-terminal disordered tail, anchored by invariant Y and N positions, a preceding acidic residue (D/E), and a trailing large aliphatic residue (V/L).","i":[[199,203,"DYVNV"],[219,223,"EYVNV"],[254,258,"DYENL"]]}],"s":"MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRDSDGANSVASYENEGASGIRGAQAGWGVWGPSWTRLTPVSLPPEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALSSQEAEEVEEEGAPDYENLQELN"},{"id":"SEQ_02684","a":"Q7Z739","g":"YTHDF3","d":"YTH domain-containing family protein 3","L":585,"m":[{"c":"[QP][PT]ψψ[PQ][PQS]","u":6,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Four tandem 6-residue repeats (0-1 aa gaps) within a P/Q-rich disordered region, anchored by a conserved internal large-aliphatic dipeptide (VL, II, LI, LV) in a regular 6-7 residue register.","i":[[292,297,"QPVLPP"],[298,303,"QTIIQQ"],[305,310,"QPLIQP"],[311,316,"PPLVQS"]]}],"s":"MSATSVDQRPKGQGNKVSVQNGSIHQKDAVNDDDFEPYLSSQTNQSNSYPPMSDPYMPSYYAPSIGFPYSLGEAAWSTAGDQPMPYLTTYGQMSNGEHHYIPDGVFSQPGALGNTPPFLGQHGFNFFPGNADFSTWGTSGSQGQSTQSSAYSSSYGYPPSSLGRAITDGQAGFGNDTLSKVPGISSIEQGMTGLKIGGDLTAAVTKTVGTALSSSGMTSIATNSVPPVSSAAPKPTSWAAIARKPAKPQPKLKPKGNVGIGGSAVPPPPIKHNMNIGTWDEKGSVVKAPPTQPVLPPQTIIQQPQPLIQPPPLVQSQLPQQQPQPPQPQQQQGPQPQAQPHQVQPQQQQLQNRWVAPRNRGAGFNQNNGAGSENFGLGVVPVSASPSSVEVHPVLEKLKAINNYNPKDFDWNLKNGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDAAYRSLNGKGPLYLLFSVNGSGHFCGVAEMKSVVDYNAYAGVWSQDKWKGKFEVKWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIATFKHTTSIFDDFAHYEKRQEEEEAMRRERNRNKQ"},{"id":"SEQ_02685","a":"Q9ULD5","g":"ZNF777","d":"Zinc finger protein 777","L":831,"m":[{"c":"[PS][FYH]xCxxCxxxFxxxxxLxxHxxxHxx[ERK]","u":27,"sp":"tandem","x":"structured_like","cf":"high","why":"Nine 27-aa repeats in the C-terminal region (arranged in two tandem clusters of 2 and 7 units separated by a 35-aa linker) featuring invariant CxxC, F, L, and HxxxH anchors flanked by N-terminal [PS][FYH] and C-terminal [ERK].","i":[[545,571,"PFTCMECGKSFRLKINLIIHQRNHIKE"],[573,599,"PYECAECEISFRHKQQLTLHQRIHRVR"],[635,661,"PYKCPECDSSFSHKSSLTKHQITHTGE"],[663,689,"PYTCPECKKSFRLHISLVIHQRVHAGK"],[693,719,"SFICSLCGKSFSRPSHLLRHQRTHTGE"],[721,747,"PFKCPECEKSFSEKSKLTNHCRVHSRE"],[749,775,"PHACPECGKSFIRKHHLLEHRRIHTGE"],[777,803,"PYHCAECGKRFTQKHHLLEHQRAHTGE"],[805,831,"PYPCTHCAKCFRYKQSLKYHLRTHTGE"]]},{"c":"[PSA]xxx[QE][EK]x[STP]xx","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Nine 10-aa repeats across the N-terminal P/S/Q/E-enriched disordered region (residues 12-166, largely embedded in a ~12-aa quasi-periodic array with 1-3 aa linkers plus wider gaps around degenerate variants) anchored by N-terminal [PSA], a central [QE][EK] polar/charged dyad, and a conserved [STP] position.","i":[[12,21,"PSVPQEETLR"],[61,70,"SAPKQETSGR"],[72,81,"PHVLQKGPSL"],[85,94,"AASEQETSLQ"],[96,105,"PLASQEGTQY"],[109,118,"AAAEQEVSLL"],[121,130,"SPHHQEAPVH"],[132,141,"PEAPEKDPLT"],[157,166,"SPVSQKDTPF"]]}],"s":"MENQRSSPLSFPSVPQEETLRQAPAGLPRETLFQSRVLPPKEIPSLSPTIPRQGSLPQTSSAPKQETSGRMPHVLQKGPSLLCSAASEQETSLQGPLASQEGTQYPPPAAAEQEVSLLSHSPHHQEAPVHSPEAPEKDPLTLSPTVPETDMDPLLQSPVSQKDTPFQISSAVQKEQPLPTAEITRLAVWAAVQAVERKLEAQAMRLLTLEGRTGTNEKKIADCEKTAVEFANHLESKWVVLGTLLQEYGLLQRRLENMENLLKNRNFWILRLPPGSNGEVPKVPVTFDDVAVHFSEQEWGNLSEWQKELYKNVMRGNYESLVSMDYAISKPDLMSQMERGERPTMQEQEDSEEGETPTDPSAAHDGIVIKIEVQTNDEGSESLETPEPLMGQVEEHGFQDSELGDPCGEQPDLDMQEPENTLEESTEGSSEFSELKQMLVQQRNCTEGIVIKTEEQDEEEEEEEEDELPQHLQSLGQLSGRYEASMYQTPLPGEMSPEGEESPPPLQLGNPAVKRLAPSVHGERHLSENRGASSQQQRNRRGERPFTCMECGKSFRLKINLIIHQRNHIKEGPYECAECEISFRHKQQLTLHQRIHRVRGGCVSPERGPTFNPKHALKPRPKSPSSGSGGGGPKPYKCPECDSSFSHKSSLTKHQITHTGERPYTCPECKKSFRLHISLVIHQRVHAGKHEVSFICSLCGKSFSRPSHLLRHQRTHTGERPFKCPECEKSFSEKSKLTNHCRVHSRERPHACPECGKSFIRKHHLLEHRRIHTGERPYHCAECGKRFTQKHHLLEHQRAHTGERPYPCTHCAKCFRYKQSLKYHLRTHTGE"},{"id":"SEQ_02688","a":"Q13936","g":"CACNA1C","d":"Voltage-dependent L-type calcium channel subunit alpha-1C","L":2221,"m":[{"c":"Fxxψψφφxψφφ[NS][CST]ψxψA(x){23,44}ψFTφEφφLKψx[AS]φ(x){39,81}φφRxφRψψR[PIL]φ+φxxxxx[SG]ψxxψψx[SCT]φφx[AS]φxxψxxψφψψxxφφxφψΩ[AS]xψGψ[EQ]ψFx[GK][KI]φ(x){11,51}F[DQ]oφxx[AS]ψψxψFxxxTxE[GDA]Wx[DES]ψψφ(x){12,30}φΩFψxφφψxx[SNA]ΩφψψNψφψ[GA]φφ","u":"227-284","sp":"dispersed","x":"structured_like","cf":"high","why":"Four large homologous polytopic membrane-pore domain repeats (227-284 aa, separated by 55-149 aa linkers) share conserved hydrophobic helices, an invariant FTxEφφLK segment, a gapless 60-aa periodic-basic RxxRxxRxx+ plus Gψ[EQ]ψF helix pair, a F[DQ]oφ...TxE[GDA]W pore motif, and a C-terminal φΩF...Nψφψ[GA]φφ segment.","i":[[126,404,"FEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVL"],[526,752,"FYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIA"],[902,1185,"FTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFV"],[1241,1523,"FEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI"]]}],"s":"MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRERHVPMCEDLELRRDSGSAGTQAHCLLLRKANPSRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKRDIRQSPKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAGQDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL"},{"id":"SEQ_02698","a":"Q5HYW2","g":"NHSL2","d":"NHS-like protein 2","L":1225,"m":[{"c":"+PP[VS]φ","u":5,"sp":"tandem","x":"disordered_like","cf":"high","why":"Four tandem copies separated by 1-2 residue linkers (871-894) in a proline/serine-rich disordered region, anchored by a conserved basic residue (+), a fixed PP dipeptide, constrained [VS], and an aliphatic hydrophobic residue (A/L/V).","i":[[868,872,"KPPVA"],[874,878,"KPPVA"],[880,884,"RPPSL"],[887,891,"KPPSV"]]}],"s":"MPFYRRTVVPQRLCPRNPPQQLAELRDVSHLAALSLLRQLADLCGHSLALLEDLEGHLLALGRRTDSLYRRTVRLRRRLPCRLLGPEEDEEELAAANSGRENATATAHSRSSWRQPVNVFLSSGRPPSVEELLREAQLNLQSLLQEEYEEQYSEARLVGQTFRSSDEATKPTPNPRPQSARRLEFILMPTKRQLSEDETTTQGVRAPEASLSLSTTADKQTAWNSLFPLPILEEKRWPQLCSTQSDIVPINISGQQFDKHASLRHSLFNTETAVNPKSTLRRRRTIIGFSNFSQRDQGHSNSPAGSVAHSTTSDIRPSHSVPEGVHGRVAVGQDARFPSLTSPVLRTPSSEPDEPHQARSGPNPPGMESMGMVYSVPSSCNGPTESTFSTSWKGDAFTYMTPSATSQSNQVNENGKNPSCGNSWVSLNKVPPLVPKEAATLLVARDNPAGCSGSAGYPERLIQQRHMPERPSKIGLLTSGTSRLETGPGGASRFRERSLSVPTDSGTTDVDYDEEQKANEACALPFASTSSEGSNSADNIASLSAQQEAQHRRQRSKSISLRKAKKKPSPPTRSVSLVKDEPGLLPEGGSALPKDQRPKSLCLSLEHQGHHSSHPDAQGHPAIPNHKDPESTQFSHHWYLTDWKSGDTYQSLSSSSTATGTTVIECTQVQGSSESLASPSTSRATTPSQLSIEVEAREISSPGRPPGLMSPSSGYSSQSETPTPTVSMSLTLGHLPPPSSSVRVRPVVPERKSSLPPTSPMEKFPKSRLSFDLPLTSSPNLDLSGMSISIRSKTKVSRHHSETNFGVKLAQKTNPNQPIMPMVTQSDLRSVRLRSVSKSEPEDDIESPEYAEEPRAEEVFTLPERKTKPPVAEKPPVARRPPSLVHKPPSVPEEYALTSPTLAMPPRSSIQHARPLPQDSYTVVRKPKPSSFPDGRSPGESTAPSSLVFTPFASSSDAFFSGTQQPPQGSVEDEGPKVRVLPERISLQSQEEAEKKKGKIPPPVPKKPSVLYLPLTSPTAQMEAYVAEPRLPLSPIITLEEDTKCPATGDDLQSLGQRVTSTPQADSEREASPLGSSVEPGTEEKSLISDKTAEWIAEDDDDVFVASRTTEDLFTVIHRSKRKLLGWKEPGEAFVGGRTSSHSPIKNTAESPISESTATAGSGSSANLDAGRNDDFKALLQKKGSKATPRSRPSAAELLKTTNPLARRIIAQFSKDYETTDNPST"},{"id":"SEQ_02705","a":"Q5T0B9","g":"ZNF362","d":"Zinc finger protein 362","L":420,"m":[{"c":"+[PTA][YH]xC(x){2,4}Cxx[AST][FY]xxx[AST]x[LM]xxHxxxHxxx","u":"28-30","sp":"tandem","x":"structured_like","cf":"high","why":"Six tandem 28-30 aa structured repeats (0-2 aa inter-unit gaps) defined by invariant C-x(2,4)-C and H-x(3)-H pairs, an N-terminal +[PTA][YH] leader, and conserved internal [FY] and [LM] core positions.","i":[[225,252,"KTYRCKVCPLTFFTKSEMQIHSKSHTEA"],[253,280,"KPHKCPHCSKSFANASYLAQHLRIHLGV"],[281,308,"KPYHCSYCDKSFRQLSHLQQHTRIHTGD"],[309,338,"RPYKCPHPGCEKAFTQLSNLQSHQRQHNKD"],[339,366,"KPYKCPNCYRAYSDSASLQIHLSAHAIK"],[369,396,"KAYCCSMCGRAYTSETYLMKHMSKHTVV"]]}],"s":"MSRSSPSGKGHSRMAEPRFNNPYFWPPPPTMPSQLDNLVLINKIKEQLMAEKIRPPHLPPTSASSQQPLLVPPAPAESSQAVMSLPKLQQVPGLHPQAVPQPDVALHARPATSTVTGLGLSTRTPSVSTSESSAGAGTGTGTSTPSTPTTTSQSRLIASSPTLISGITSPPLLDSIKTIQGHGLLGPPKSERGRKKIKAENPGGPPVLVVPYPILASGETAKEGKTYRCKVCPLTFFTKSEMQIHSKSHTEAKPHKCPHCSKSFANASYLAQHLRIHLGVKPYHCSYCDKSFRQLSHLQQHTRIHTGDRPYKCPHPGCEKAFTQLSNLQSHQRQHNKDKPYKCPNCYRAYSDSASLQIHLSAHAIKHAKAYCCSMCGRAYTSETYLMKHMSKHTVVEHLVSHHSPQRTESPGIPVRISLI"},{"id":"SEQ_02708","a":"Q99569","g":"PKP4","d":"Plakophilin-4","L":1192,"m":[{"c":"xxψxxφ(x){15,21}[ACTV]xxLxxψ(x){8,12}φxxx","u":"42-48","sp":"tandem","x":"structured_like","cf":"high","why":"Eight ~42-48 aa helical repeat units arranged in two head-to-tail tandem blocks (528-763 and 825-1003, separated by a central basic/polar insert loop and one loop-expanded unit at 656-715), anchored by a 100% conserved central L in an [ACTV]xxLxxψ core alongside conserved N- and C-terminal hydrophobic register positions.","i":[[528,569,"PELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRL"],[570,613,"GGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAMKNV"],[614,655,"GGIPALLRLLRKSIDAEVRELVTGVLWNLSSCDAVKMTIIRD"],[716,763,"GLVDSLLYVIHTCVNTSDYDSKTVENCVCTLRNLSYRLELEVPQARLL"],[825,869,"SVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVR"],[872,915,"KGLPILVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMR"],[916,959,"DLVNRLPGGNGPSVLSDETMAAICCALHEVTSKNMENAKALADS"],[960,1003,"GGIEKLVNITKGRGDRSSLKVVKAAAQVLNTLWQYRDLRSIYKK"]]},{"c":"R[AVP][AGQ]SP","u":5,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Five dispersed copies of a proline-directed basophilic pentapeptide motif clustered within the N-terminal disordered region (residues 217-328), sharing invariant R and SP anchors separated by a tightly constrained small/aliphatic [AVP][AGQ] dipeptide.","i":[[218,222,"RAQSP"],[270,274,"RAASP"],[278,282,"RPASP"],[311,315,"RVGSP"],[324,328,"RVASP"]]}],"s":"MPAPEQASLVEEGQPQTRQEAASTGPGMEPETTATTILASVKEQELQFQRLTRELEVERQIVASQLERCRLGAESPSIASTSSTEKSFPWRSTDVPNTGVSKPRVSDAVQPNNYLIRTEPEQGTLYSPEQTSLHESEGSLGNSRSSTQMNSYSDSGYQEAGSFHNSQNVSKADNRQQHSFIGSTNNHVVRNSRAEGQTLVQPSVANRAMRRVSSVPSRAQSPSYVISTGVSPSRGSLRTSLGSGFGSPSVTDPRPLNPSAYSSTTLPAARAASPYSQRPASPTAIRRIGSVTSRQTSNPNGPTPQYQTTARVGSPLTLTDAQTRVASPSQGQVGSSSPKRSGMTAVPQHLGPSLQRTVHDMEQFGQQQYDIYERMVPPRPDSLTGLRSSYASQHSQLGQDLRSAVSPDLHITPIYEGRTYYSPVYRSPNHGTVELQGSQTALYRTGSVGIGNLQRTSSQRSTLTYQRNNYALNTTATYAEPYRPIQYRVQECNYNRLQHAVPADDGTTRSPSIDSIQKDPREFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSSCDAVKMTIIRDALSTLTNTVIVPHSGWNNSSFDDDHKIKFQTSLVLRNTTGCLRNLSSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDYDSKTVENCVCTLRNLSYRLELEVPQARLLGLNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWDGVGPIPGLSKSPKGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRLPGGNGPSVLSDETMAAICCALHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSLKVVKAAAQVLNTLWQYRDLRSIYKKDGWNQNHFITPVSTLERDRFKSHPSLSTTNQQMSPIIQSVGSTSSSPALLGIRDPRSEYDRTQPPMQYYNSQGDATHKGLYPGSSKPSPIYISSYSSPAREQNRRLQHQQLYYSQDDSNRKNFDAYRLYLQSPHSYEDPYFDDRVHFPASTDYSTQYGLKSTTNYVDFYSTKRPSYRAEQYPGSPDSWV"},{"id":"SEQ_02709","a":"P41229","g":"KDM5C","d":"Lysine-specific demethylase 5C","L":1560,"m":[{"c":"[LQ]xxxxxxxxxWxxx[AV]xxxx(x){4,8}xxxx[LM]xx[LI]","u":"31-35","sp":"dispersed","x":"structured_like","cf":"high","why":"Six copies of a ~31-35 aa three-helix bundle repeat (four clustered in 920-1102 with 11-18 aa linkers plus two flanking copies at 764-798 and 1278-1308) anchored by an N-terminal L/Q, an invariant W followed by [AV] at +4, a 4-8 aa inter-helical loop, and a C-terminal [LM]xx[LI] hydrophobic core.","i":[[763,797,"LKVRAESFDTWANKVRVALEVEDGRKRSLEELRAL"],[920,953,"QLQRQVEQARWLDEVKRTLAPSARRGTLAVMRGL"],[973,1005,"LQELLTIAERWEEKAHLCLEARQKHPPATLEAI"],[1022,1054,"LKEALAKARAWIADVDEIQNGDHYPCLDDLEGL"],[1071,1102,"LELQVLTAHSWREKASKTFLKKNSCYTLLEVL"],[1278,1308,"LQCLTERAISWQGRARQALASEDVTALLGRL"]]},{"c":"C(x){1,2}C(x){7,8}[AL]LxC[DY]xCxD(x){11,36}C(x){1,2}C","u":"34-60","sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed cysteine/histidine-rich zinc-binding modules sharing paired N- and C-terminal C(x){1,2}C motifs and a conserved central [AL]LxC[DY]xCxD core separated by variable loops.","i":[[327,371,"CRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPEIPKGVWRCPKC"],[707,740,"CIKCKTTCFLSALACYDCPDGLVCLSHINDLCKC"],[1188,1247,"CVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLC"]]}],"s":"MEPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVVEEGGYEAICKDRRWARVAQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRPFDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYGAGPKMMGLGLMAKDKTLRKKDKEGPECPPTVVVKEELGGDVKVESTSPKTFLESKEELSHSPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPEIPKGVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTELVEKEFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRLRKALLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPAMLHKLKVRAESFDTWANKVRVALEVEDGRKRSLEELRALESEARERRFPNSELLQQLKNCLSEAEACVSRALGLVSGQEAGPHRVAGLQMTLTELRAFLDQMNNLPCAMHQIGDVKGVLEQVEAYQAEAREALASLPSSPGLLQSLLERGRQLGVEVPEAQQLQRQVEQARWLDEVKRTLAPSARRGTLAVMRGLLVAGASVAPSPAVDKAQAELQELLTIAERWEEKAHLCLEARQKHPPATLEAIIREAENIPVHLPNIQALKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDPLREGSGKDMPKVQGLLENGDSVTSPEKVAPEEGSGKRDLELLSSLLPQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLERIRTLLELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQENQNGLEPAEGTTSGPSAPFSTLTPRLHLPCPQQPPQQQL"},{"id":"SEQ_02728","a":"Q14781","g":"CBX2","d":"Chromobox protein homolog 2","L":532,"m":[{"c":"KRG[KPR]+[PG][RL]","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed basic-glycine-proline hook motifs in the central disordered region share an invariant N-terminal KRG anchor followed by a basic/proline core (+ at position 5 and P/G at position 6), with each copy also embedding an overlapping RGR tripeptide.","i":[[71,77,"KRGKRPR"],[131,137,"KRGPRGR"],[163,169,"KRGRKPL"]]}],"s":"MEELSSVGEQVFAAECILSKRLRKGKLEYLVKWRGWSSKHNSWEPEENILDPRLLLAFQKKEHEKEVQNRKRGKRPRGRPRKLTAMSSCSRRSKLKEPDAPSKSKSSSSSSSSTSSSSSSDEEDDSDLDAKRGPRGRETHPVPQKKAQILVAKPELKDPIRKKRGRKPLPPEQKATRRPVSLAKVLKTARKDLGAPASKLPPPLSAPVAGLAALKAHAKEACGGPSAMATPENLASLMKGMASSPGRGGISWQSSIVHYMNRMTQSQAQAASRLALKAQATNKCGLGLDLKVRTQKGELGMSPPGSKIPKAPSGGAVEQKVGNTGGPPHTHGASRVPAGCPGPQPAPTQELSLQVLDLQSVKNGMPGVGLLARHATATKGVPATNPAPGKGTGSGLIGASGATMPTDTSKSEKLASRAVAPPTPASKRDCVKGSATPSGQESRTAPGEARKAATLPEMSAGEESSSSDSDPDSASPPSTGQNPSVSVQTSQDWKPTRSLIEHVFVTDVTANLITVTVKESPTSVGFFNLRHY"},{"id":"SEQ_02758","a":"Q9H9P5","g":"UNKL","d":"Putative E3 ubiquitin-protein ligase UNKL","L":680,"m":[{"c":"[FY](x){4,6}C(x){6,14}C(x){5,7}CxxxH","u":"23-31","sp":"dispersed","x":"structured_like","cf":"high","why":"Six dispersed CCCH-type zinc-coordinating repeats anchored by an N-terminal [FY] leader residue, three invariant cysteines, and a C-terminal CxxxH motif containing an internal aromatic residue. These six units are arranged into two homologous three-repeat cassettes (~31-153 and ~208-321) sharing additional sequence conservation across corresponding repeats.","i":[[31,56,"FRTEQCPLFSQHKCAQHRPFTCFHWH"],[75,101,"YSPDVYCSKYNEATGVCPDGDECPYLH"],[116,142,"YKTGTCIHETDARGHCVKNGLHCAFAH"],[208,230,"YKTEQCPKPPRLCRQGYACPHYH"],[244,274,"YRSTPCPSVKHGDEWGEPSRCDGGDGCQYCH"],[281,307,"FHPESTKCNDMRQTGYCPRGPFCAFAH"]]}],"s":"MPSVSKAAAAALSGSPPQTEKPTHYRYLKEFRTEQCPLFSQHKCAQHRPFTCFHWHFLNQRRRRPLRRRDGTFNYSPDVYCSKYNEATGVCPDGDECPYLHRTTGDTERKYHLRYYKTGTCIHETDARGHCVKNGLHCAFAHGPLDLRPPVCDVRELQAQEALQNGQLGGGEGVPDLQPGVLASQAMIEKILSEDPRWQDANFVLGSYKTEQCPKPPRLCRQGYACPHYHNSRDRRRNPRRFQYRSTPCPSVKHGDEWGEPSRCDGGDGCQYCHSRTEQQFHPESTKCNDMRQTGYCPRGPFCAFAHVEKSLGMVNEWGCHDLHLTSPSSTGSGQPGNAKRRDSPAEGGPRGSEQDSKQNHLAVFAAVHPPAPSVSSSVASSLASSAGSGSSSPTALPAPPARALPLGPASSTVEAVLGSALDLHLSNVNIASLEKDLEEQDGHDLGAAGPRSLAGSAPVAIPGSLPRAPSLHSPSSASTSPLGSLSQPLPGPVGSSAMTPPQQPPPLRSEPGTLGSAASSYSPLGLNGVPGSIWDFVSGSFSPSPSPILSAGPPSSSSASPNGAELARVRRQLDEAKRKIRQWEESWQQVKQVCDAWQREAQEAKERARVADSDRQLALQKKEEVEAQVIFQLRAKQCVACRERAHGAVLRPCQHHILCEPCAATAPECPYCKGQPLQW"},{"id":"SEQ_02769","a":"Q9P202","g":"WHRN","d":"Whirlin","L":907,"m":[{"c":"V[RN]ψxxx(x){3,8}LGφ[STA]I[RE]GG(x){3,5}[GP]ψ[GP]xφψ[ST]xxx[PG]GSx[AH]xxx[GQ]L+VG[DH]xIL[RE]VN[DG]x[ST]φxxxxHxEA[VA]+φψ[KA]x(x){3,8}φψxxψx","u":"78-84","sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed ~80-aa structured domain repeats strongly anchored by conserved LGφ[STA]I[RE]GG, GS, [GQ]L+VG[DH]xIL[RE]VN[DG], and HxEA[VA]+φψ[KA]x motifs with minor loop length variation.","i":[[138,219,"VRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVY"],[280,357,"VNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVK"],[817,900,"VRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFKTKDRDYIDFLV"]]}],"s":"MNAPLDGLSVSSSSTGSLGSAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTHCLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATTPYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVGRLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGNQTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVRGTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSSARNTLDLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLAQGNDLPLGQPRKLGREDLQPPSSMPSCSGTVFSAPQNRSPPAGTAPTPGTSSAQDLPSSPIYASVSPANPSSKRPLDAHLALVNQHPIGPFPRVQSPPHLKSPSAEATVAGGCLLPPSPSGHPDQTGTNQHFVMVEVHRPDSEPDVNEVRALPQTRTASTLSQLSDSGQTLSEDSGVDAGEAEASAPGRGRQSVSTKSRSSKELPRNERPTDGANKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFKTKDRDYIDFLVTEFNVML"},{"id":"SEQ_02770","a":"Q8NC51","g":"SERBP1","d":"SERPINE1 mRNA-binding protein 1","L":408,"m":[{"c":"ψ-xxφRKPxxxφx[GS]QφxxxF","u":20,"sp":"periodic","x":"structured_like","cf":"medium","why":"Two adjacent 20-aa repeats separated by a 16-aa linker in the C-terminal structured region, sharing an exact gapless register across ψ-, φRKP, [GS]Qφ, and C-terminal F anchors.","i":[[304,323,"VEFNIRKPNEGADGQWKKGF"],[340,359,"MDHHFRKPANDITSQLEINF"]]}],"s":"MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQTNSNAAGKQLRKESQKDRKNPLPPSVGVVDKKEETQPPVALKKEGIRRVGRRPDQQLQGEGKIIDRRPERRPPRERRFEKPLEEKGEGGEFSVDRPIIDRPIRGRGGLGRGRGGRGRGMGRGDGFDSRGKREFDRHSGSDRSSFSHYSGLKHEDKRGGSGSHNWGTVKDELTESPKYIQKQISYNYSDLDQSNVTEETPEGEEHHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKDRAKVEFNIRKPNEGADGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFGDLGRPGRGGRGGRGGRGRGGRPNRGSRTDKSSASAPDVDDPEAFPALA"},{"id":"SEQ_02790","a":"Q8IYT1","g":"GARIN4","d":"Golgi-associated RAB2 interactor protein 4","L":594,"m":[{"c":"φAψAG[ATV][AV]","u":7,"sp":"dispersed","x":"mixed","cf":"medium","why":"Four dispersed 7-residue hydrophobic-glycine motifs in the central region (residues 310-376) share an invariant AxAG core with a strictly conserved large aliphatic residue (I/L/V) at position 3 and hydrophobic flanking positions, separated by variable 8-21 aa polar linkers; copies 1 and 4 also share broader flanking similarity (GQVSAAIAGAATIG vs GSVSLAIAGVVLTS).","i":[[310,316,"AAIAGAA"],[327,333,"MALAGTA"],[342,348,"VAVAGAA"],[370,376,"LAIAGVV"]]}],"s":"MNADFLLPYYTAQSGSSMSMFNTTMGKLQRQLYKGEYDIFKYAPIFESDFIQITKRGEVIDVHNRVRMVTMGIARTSPILPLPDVMLLARPATGCEEYAGHGQATKRKKRKAAKNLELTRLLPLRFVRISVQDHEKQQLRLKFATGRSCYLQLCPALDTRDDLFAYWEKLIYLLRPPMESNSSTCGIPAEDMMWMPVFQEDRRSLGAVNLQGKGDQDQVSIQSLHMVSEVCGATSAAYAGGEGLQNDFNKPTNVLNASIPKTSTELAEEPATGGIKEAAAAGAAAGAATGTVAGALSVAAANSAPGQVSAAIAGAATIGAGGNKGNMALAGTASMAPNSTKVAVAGAAGKSSEHVSSASMSLSREGSVSLAIAGVVLTSRTAAEADMDAAAGPPVSTRQSKSSLSGQHGRERTQASAEGCKEGRERREKDRALGRSSHRRRTGESRHKTRGDKIAQKSSSRSSFSHRANRDDKKEKGCGNPGSSRHRDSHKGVSHTPISKESRTSHKSGRSLWTTSSGSSKGLGRVSSFLRNVRANLTTKVVGTPHGRDVNVMAKMAERSTNVAIAETAEGGQGLETVGSMTPDIMETVTFEAH"},{"id":"SEQ_02806","a":"Q9BTC0","g":"DIDO1","d":"Death-inducer obliterator 1","L":2240,"m":[{"c":"xxR[GVA]xxPx[QHR]F","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Nine 10-aa copies anchored by invariant R3, P7, and C-terminal F10 (predominantly a GPRGxxPSQF core) within a proline/glycine-rich C-terminal region (aa 1791-1989). Several instances cluster in tandem 11-aa steps (1-aa linkers) interspersed with short variable linkers and length-variant copies (such as 11-aa GPRGGPPPSQF).","i":[[1791,1800,"GPRGPPPARF"],[1833,1842,"GPRGVAPSQF"],[1880,1889,"GSRGGAPFQF"],[1914,1923,"GQRGPPPGHF"],[1925,1934,"GPRGPHPSQF"],[1936,1945,"TARGPHPNQF"],[1958,1967,"GPRGIQPQQF"],[1969,1978,"DQRVHSPPRF"],[1980,1989,"NQRAPAPLQF"]]},{"c":"-WDRxR","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four 6-aa repeats embedded in the R/D/E/S-rich C-terminal disordered tail (aa 2128-2173), anchored by an N-terminal acidic residue ([DE]) and invariant W2, D3, R4, and R6 positions. The first two copies occur head-to-tail followed by two dispersed copies.","i":[[2128,2133,"DWDRPR"],[2134,2139,"EWDRHR"],[2146,2151,"DWDRNR"],[2168,2173,"EWDRSR"]]},{"c":"AAA[MT][AP]A[SI]KK","u":9,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 9-aa motifs in the central P/A/S/K-rich disordered linker (aa 541-627) sharing a conserved AAAN-terminal and C-terminal KK anchor pair with constrained internal positions, each immediately followed within 0-2 residues by a P[GS] motif.","i":[[541,549,"AAAMAASKK"],[577,585,"AAATPAIKK"],[619,627,"AAATAASKK"]]}],"s":"MDDKGDPSNEEAPKAIKPTSKEFRKTWGFRRTTIAKREGAGDAEADPLEPPPPQQQLGLSLRRSGRQPKRTERVEQFLTIARRRGRRSMPVSLEDSGEPTSCPATDAETASEGSVESASETRSGPQSASTAVKERPASSEKVKGGDDHDDTSDSDSDGLTLKELQNRLRRKREQEPTERPLKGIQSRLRKKRREEGPAETVGSEASDTVEGVLPSKQEPENDQGVVSQAGKDDRESKLEGKAAQDIKDEEPGDLGRPKPECEGYDPNALYCICRQPHNNRFMICCDRCEEWFHGDCVGISEARGRLLERNGEDYICPNCTILQVQDETHSETADQQEAKWRPGDADGTDCTSIGTIEQKSSEDQGIKGRIEKAANPSGKKKLKIFQPVIEAPGASKCIGPGCCHVAQPDSVYCSNDCILKHAAATMKFLSSGKEQKPKPKEKMKMKPEKPSLPKCGAQAGIKISSVHKRPAPEKKETTVKKAVVVPARSEALGKEAACESSTPSWASDHNYNAVKPEKTAAPSPSLLYKSTKEDRRSEEKAAAMAASKKTAPPGSAVGKQPAPRNLVPKKSSFANVAAATPAIKKPPSGFKGTIPKRPWLSATPSSGASAARQAGPAPAAATAASKKFPGSAALVGAVRKPVVPSVPMASPAPGRLGAMSAAPSQPNSQIRQNIRRSLKEILWKRVNDSDDLIMTENEVGKIALHIEKEMFNLFQVTDNRYKSKYRSIMFNLKDPKNQGLFHRVLREEISLAKLVRLKPEELVSKELSTWKERPARSVMESRTKLHNESKKTAPRQEAIPDLEDSPPVSDSEEQQESARAVPEKSTAPLLDVFSSMLKDTTSQHRAHLFDLNCKICTGQVPSAEDEPAPKKQKLSASVKKEDLKSKHDSSAPDPAPDSADEVMPEAVPEVASEPGLESASHPNVDRTYFPGPPGDGHPEPSPLEDLSPCPASCGSGVVTTVTVSGRDPRTAPSSSCTAVASAASRPDSTHMVEARQDVPKPVLTSVMVPKSILAKPSSSPDPRYLSVPPSPNISTSESRSPPEGDTTLFLSRLSTIWKGFINMQSVAKFVTKAYPVSGCFDYLSEDLPDTIHIGGRIAPKTVWDYVGKLKSSVSKELCLIRFHPATEEEEVAYISLYSYFSSRGRFGVVANNNRHVKDLYLIPLSAQDPVPSKLLPFEGPGLESPRPNIILGLVICQKIKRPANSGELDKMDEKRTRLQPEEADVPAYPKVATVPQSEKKPSKYPLCSADAAVSTTPPGSPPPPPPLPEPPVLKVLSSLKPAAPSPATAATTAAAASTAASSTASSASKTASPLEHILQTLFGKKKSFDPSAREPPGSTAGLPQEPKTTAEDGVPAPPLLDPIVQQFGQFSKDKALEEEEDDRPYDPEEEYDPERAFDTQLVERGRRHEVERAPEAAAAEREEVAYDPEDETILEEAKVTVDDLPNRMCADVRRNSVERPAEPVAGAATPSLVEQQKMLEELNKQIEEQKRQLEEQEEALRQQRAAVGVSMAHFSVSDALMSPPPKSSLPKAELFQQEQQSADKPASLPPASQASNHRDPRQARRLATETGEGEGEPLSRLSARGAQGALPERDASRGGLVGQAPMPVPEEKEPASSPWASGEKPPAGSEQDGWKAEPGEGTRPATVGDSSARPARRVLLPTPPCGALQPGFPLQHDGERDPFTCPGFASQDKALGSAQYEDPRNLHSAGRSSSPAGETEGDREPQARPGEGTAPLPPPGQKVGGSQPPFQGQREPGPHALGMSGLHGPNFPGPRGPAPPFPEENIASNDGPRGPPPARFGAQKGPIPSLFSGQHGPPPYGDSRGPSPSYLGGPRGVAPSQFEERKDPHGEKREFQDAPYNEVTGAPAQFEGTEQAPFLGSRGGAPFQFGGQRRPLLSQLKGPRGGPPPSQFGGQRGPPPGHFVGPRGPHPSQFETARGPHPNQFEGPRGQAPNFMPGPRGIQPQQFEDQRVHSPPRFTNQRAPAPLQFGGLRGSAPFSEKNEQTPSRFHFQGQAPQVMKPGPRPLLELPSHPPQHRKDRWEEAGPPSALSSSAPGQGPEADGQWASADFREGKGHEYRNQTFEGRQRERFDVGPKEKPLEEPDAQGRASEDRRRERERGRNWSRERDWDRPREWDRHRDKDSSRDWDRNRERSANRDREREADRGKEWDRSRERSRNRERERDRRRDRDRSRSRERDRDKARDRERGRDRKDRSKSKESARDPKPEASRASDAGTASQA"},{"id":"SEQ_02819","a":"Q8TBB5","g":"KLHDC4","d":"Kelch domain-containing protein 4","L":520,"m":[{"c":"[PG]R(x){12,16}φφ[FY]GG(x){12,17}-ψxx[LYF](x){6,11}Wxxxx","u":"47-58","sp":"dispersed","x":"structured_like","cf":"high","why":"Six structured beta-propeller-like repeats anchored by N-terminal [PG]R, an invariant φφ[FY]GG core, an acidic-aliphatic -ψxx[LYF] strand, and a conserved C-terminal W residue; the first five copies are separated by short 5-7 aa linkers while the sixth is separated by an 84 aa insertion.","i":[[63,111,"PRLNASLSVHPEKDELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVD"],[117,169,"PRRCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVK"],[176,222,"GRSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLS"],[230,287,"PRSGCQMSVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWTRMN"],[295,346,"PRSGFSVAMAPNHQTLFFGGVCDEEEEESLSGEFFNDLYFYDATRNRWFEGQ"],[431,478,"PRSNAMLAVKHGVLYVYGGMFEAGDRQVTLSDLHCLDLHRMEAWKALV"]]}],"s":"MGKKGKKEKKGRGAEKTAAKMEKKVSKRSRKEEEDLEALIAHFQTLDAKRTQTVELPCPPPSPRLNASLSVHPEKDELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPRRCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKSTGGPSGRSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWTRMNPSGVKPTPRSGFSVAMAPNHQTLFFGGVCDEEEEESLSGEFFNDLYFYDATRNRWFEGQLKGPKSEKKKRRRGRKEEPEGGSRPACGGAGTQGPVQLVKEVVAEDGTVVTIKQVLTAPGSAGQPRSEDEDSLEEAGSPAPGPCPRSNAMLAVKHGVLYVYGGMFEAGDRQVTLSDLHCLDLHRMEAWKALVEMDPETQEWLEETDSEEDSEEVEGAEGGVDDEDSGEESGAED"},{"id":"SEQ_02823","a":"A0A1B0GUY1","g":"MARCOL","d":"MARCO-like protein","L":285,"m":[{"c":"[QK][QK][GE][NK][PL]G[SL]S[STG]","u":9,"sp":"tandem","x":"disordered_like","cf":"high","why":"Nineteen contiguous head-to-tail 9-aa repeats (residues 110-280, followed by a 5-aa C-terminal partial RQGNL and preceded by two divergent upstream 9-mers at 63-80) in a polar disordered-like region, strongly anchored by N-terminal Q-rich dipeptides, central [GE][NK][PL]G, and C-terminal [SL]S[STG].","i":[[110,118,"QKGNPESSN"],[119,127,"KQENSGSSS"],[128,136,"QLGRPGIST"],[137,145,"QQGNPGSSD"],[146,154,"QQEKPGSFS"],[155,163,"QKVMVGSSS"],[164,172,"QQGKPGSSS"],[173,181,"QHGNLGSST"],[182,190,"QKGNLGSSS"],[191,199,"LQGHLGLSS"],[200,208,"HQGKPESSG"],[209,217,"QQGKPGSSS"],[218,226,"QQGNLGTSG"],[227,235,"QQEKPGSSS"],[236,244,"QQGKPGLSS"],[245,253,"HQGKPGSSS"],[254,262,"QQGNLHLSS"],[263,271,"QQGNQGPSS"],[272,280,"KQRKPGSSS"]]}],"s":"MRAFIFFLFMLLAMFSASSTQISNTSVFKLEENPKPALILEEKNEANHLGGQRDSNKQGGSYTQGNPGTFRLQGQPGYFNKLEKPRHFKQGRAGVLNQPGILKNSGKSNQKGNPESSNKQENSGSSSQLGRPGISTQQGNPGSSDQQEKPGSFSQKVMVGSSSQQGKPGSSSQHGNLGSSTQKGNLGSSSLQGHLGLSSHQGKPESSGQQGKPGSSSQQGNLGTSGQQEKPGSSSQQGKPGLSSHQGKPGSSSQQGNLHLSSQQGNQGPSSKQRKPGSSSRQGNL"},{"id":"SEQ_02826","a":"Q9H3R0","g":"KDM4C","d":"Lysine-specific demethylase 4C","L":1056,"m":[{"c":"GxxVxxKxxxx+φYxx+φφxxoxxxφYxVxF-DGS(x){6,7}EDIφ[ST]xD","u":"48-49","sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 48-49 aa C-terminal domain copies separated by a 9-aa linker, sharing 14 identical anchor residues (including G, V, K, two Ys, F-DGS, and EDI...D) plus 10 conserved hydrophobic, basic, acidic, and polar positions across a 6-7 aa variable loop.","i":[[882,930,"GQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVSRD"],[940,987,"GEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLD"]]}],"s":"MEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQCYDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRKDMVKISMDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTPASTPEVKAWLQRRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTDDLKVSEKSEAAVKLRNTEASSEEESSASRMQVEQNLSDHIKLSGNSCLSTSVTEDIKTEDDKAYAYRSVPSISSEADDSIPLSSGYEKPEKSDPSELSWPKSPESCSSVAESNGVLTEGEESDVESHGNGLEPGEIPAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARSPMTLVKQQAPSDEELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADIIQGERKRQRVLSSRFKNEYVADPVYRTFLKSSFQKKCQKRQ"},{"id":"SEQ_02854","a":"Q9P2B7","g":"CFAP97","d":"Cilia- and flagella-associated protein 97","L":532,"m":[{"c":"Ex[RQ][QR]I-RENxxLLK[ER]L(x){3,5}KP","u":"21-23","sp":"dispersed","x":"mixed","cf":"high","why":"Strongly conserved 2-copy internal duplication anchored by 11 identical residues (E, I, R, E, N, L, L, K, L, and a C-terminal KP helix-capping dipeptide) plus an acidic D/E position, separated by a 25-aa proline-containing linker.","i":[[383,405,"EVRQIDRENQRLLKELSRQAEKP"],[431,451,"EQQRIERENLALLKRLEAVKP"]]}],"s":"MDQFGDILEGEVDHSFFDSDFEEGKKCETNSVFDKQNDDPKERIDKDTKNVNSNTGMQTTENYLTEKGNERNVKFPPEHPVENDVTQTVSSFSLPASSRSKKLCDVTTGLKIHVSIPNRIPKIVKEGEDDYYTDGEESSDDGKKYHVKSKSAKPSTNVKKSIRKKYCKVSSSSSSSLSSSSSGSGTDCLDAGSDSHLSDSSPSSKSSKKHVSGITLLSPKHKYKSGIKSTETQPSSTTPKCGHYPEESEDTVTDVSPLSTPDISPLQSFELGIANDQKVKIKKQENVSQEIYEDVEDLKNNSKYLKAAKKGKEKHEPDVSSKSSSVLDSSLDHRHKQKVLHDTMDLNHLLKAFLQLDKKGPQKHHFDQPSVAPGKNYSFTREEVRQIDRENQRLLKELSRQAEKPGSKSTIPRSADHPPKLYHSALNRQKEQQRIERENLALLKRLEAVKPTVGMKRSEQLMDYHRNMGYLNSSPLSRRARSTLGQYSPLRASRTSSATSGLSCRSERSAVDPSSGHPRRRPKPPNVRTAWL"},{"id":"SEQ_02879","a":"Q15311","g":"RALBP1","d":"RalA-binding protein 1","L":655,"m":[{"c":"KEEKH","u":5,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Three identical head-to-tail pentapeptide copies in the basic/acidic N-terminal disordered region, anchored at every fifth position by a conserved histidine residue.","i":[[132,136,"KEEKH"],[137,141,"KEEKH"],[142,146,"KEEKH"]]}],"s":"MTECFLPPTSSPSEHRRVEHGSGLTRTPSSEEISPTKFPGLYRTGEPSPPHDILHEPPDVVSDDEKDHGKKKGKFKKKEKRTEGYAAFQEDSSGDEAESPSKMKRSKGIHVFKKPSFSKKKEKDFKIKEKPKEEKHKEEKHKEEKHKEKKSKDLTAADVVKQWKEKKKKKKPIQEPEVPQIDVPNLKPIFGIPLADAVERTMMYDGIRLPAVFRECIDYVEKYGMKCEGIYRVSGIKSKVDELKAAYDREESTNLEDYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTETEKVQEFQRLLKELPECNYLLISWLIVHMDHVIAKELETKMNIQNISIVLSPTVQISNRVLYVFFTHVQELFGNVVLKQVMKPLRWSNMATMPTLPETQAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKEERLWEVQRILTALKRKLREAKRQECETKIAQEIASLSKEDVSKEEMNENEEVINILLAQENEILTEQEELLAMEQFLRRQIASEKEEIERLRAEIAEIQSRQQHGRSETEEYSSESESESEDEEELQIILEDLQRQNEELEIKNNHLNQAIHEEREAIIELRVQLRLLQMQRAKAEQQAQEDEEPEWRGGAVQPPRDGVLEPKAAKEQPKAGKEPAKPSPSRDRKETSI"},{"id":"SEQ_02887","a":"Q96PK6","g":"RBM14","d":"RNA-binding protein 14","L":669,"m":[{"c":"KIFVGNV(x){5,6}[PS][EQ]ELx[AS]LFxxxGxVψxCVψKxΩAFVHMxxxAxAxxAIxxL[HN]G[HK]Eψ+(x){3,4}ψxVEψS","u":"68-70","sp":"dispersed","x":"structured_like","cf":"high","why":"Strongly conserved N-terminal globular domain duplication separated by an 8-residue linker, featuring identical KIFVGNV and ΩAFVHM signature motifs plus conserved hydrophobic cores and minor 1-residue loop length variations.","i":[[2,71,"KIFVGNVDGADTTPEELAALFAPYGTVMSCAVMKQFAFVHMRENAGALRAIEALHGHELRPGRALVVEMS"],[80,147,"KIFVGNVSAACTSQELRSLFERRGRVIECDVVKDYAFVHMEKEADAKAAIAQLNGKEVKGKRINVELS"]]},{"c":"YxxQxxx","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Extensive 26-copy YxxQ-anchored repeat array spanning residues 235-546 in a low-complexity A/Q/P/S/G-rich disordered region, where invariant Y and Q anchors mark contiguous 7-13 aa head-to-tail repeat units (including tandem 7-mers and 12-mers).","i":[[237,243,"YRAQPSV"],[249,255,"YRAQPSA"],[261,267,"YRTQPMT"],[273,279,"YRAQPSV"],[285,291,"YRGQLAS"],[331,337,"YGAQGSS"],[341,347,"YGNQPSS"],[348,354,"YGAQAAS"],[365,371,"YNTQGAA"],[377,383,"YGAQAAS"],[384,390,"YGAQSAA"],[395,401,"YGAQAAS"],[402,408,"YNAQPSA"],[410,416,"YNAQSAP"],[417,423,"YAAQQAA"],[425,431,"YSSQPAA"],[432,438,"YVAQPAT"],[442,448,"YASQPAA"],[449,455,"YAAQATT"],[461,467,"YGAQPVV"],[474,480,"YGAQASM"],[486,492,"YGAQSAA"],[504,510,"YGAQPSA"],[516,522,"YRTQSSA"],[528,534,"YAAQQHP"],[540,546,"YRGQPGN"]]},{"c":"[SLN]DY[RAL]Rφ","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed hexapeptide copies clustered in the C-terminal disordered tail sharing invariant DY and R anchors flanked by constrained polar/aliphatic N-terminal and hydrophobic C-terminal positions.","i":[[612,617,"SDYRRL"],[633,638,"LDYRRL"],[643,648,"SDYARY"],[653,658,"NDYLRA"]]}],"s":"MKIFVGNVDGADTTPEELAALFAPYGTVMSCAVMKQFAFVHMRENAGALRAIEALHGHELRPGRALVVEMSRPRPLNTWKIFVGNVSAACTSQELRSLFERRGRVIECDVVKDYAFVHMEKEADAKAAIAQLNGKEVKGKRINVELSTKGQKKGPGLAVQSGDKTKKPGAGDTAFPGTGGFSATFDYQQAFGNSTGGFDGQARQPTPPFFGRDRSPLRRSPPRASYVAPLTAQPATYRAQPSVSLGAAYRAQPSASLGVGYRTQPMTAQAASYRAQPSVSLGAPYRGQLASPSSQSAAASSLGPYGGAQPSASALSSYGGQAAAASSLNSYGAQGSSLASYGNQPSSYGAQAASSYGVRAAASSYNTQGAASSLGSYGAQAASYGAQSAASSLAYGAQAASYNAQPSASYNAQSAPYAAQQAASYSSQPAAYVAQPATAAAYASQPAAYAAQATTPMAGSYGAQPVVQTQLNSYGAQASMGLSGSYGAQSAAAATGSYGAAAAYGAQPSATLAAPYRTQSSASLAASYAAQQHPQAAASYRGQPGNAYDGAGQPSAAYLSMSQGAVANANSTPPPYERTRLSPPRASYDDPYKKAVAMSKRYGSDRRLAELSDYRRLSESQLSFRRSPTKSSLDYRRLPDAHSDYARYSGSYNDYLRAAQMHSGYQRRM"},{"id":"SEQ_02892","a":"Q9Y6X6","g":"MYO16","d":"Unconventional myosin-XVI","L":1858,"m":[{"c":"[GFY]x[STI][PL][LM][HD]φ[AC][ACV]xx(x){0,2}[DGS]xxxψφxφ[LI]xxx[GQ][AVG][ND][VLP]xxxxxx","u":"33-35","sp":"tandem","x":"structured_like","cf":"high","why":"Five 33-35 aa helix-turn-helix structural repeats in the N-terminal domain arranged in two head-to-tail tandem blocks (3 copies and 2 copies separated by a 28-aa linker), anchored by conserved [PL][LM][HD]φA turn-helix motifs, dual hydrophobic helix cores (ψφxφ[LI]), and a C-terminal [GQ][AVG][ND] turn.","i":[[93,125,"GGSLLHLCARYDNAFIAEILIDRGVNVNHQDED"],[126,158,"FWTPMHIACACDNPDIVLLLVLAGANVLLQDVN"],[159,193,"GNIPLDYAVEGTESSSILLTYLDENGVDLTSLRQM"],[222,254,"GVTLLHMACASGYKEVVSLILEHGGDLNIVDDQ"],[255,287,"YWTPLHLAAKYGQTNLVKLLLMHQANPHLVNCN"]]},{"c":"+KxPP[PR]KPKR[DS]PNT+LS[AG]SYE[AE]ψS","u":24,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Internal duplication of a 24-aa motif in the C-terminal disordered region separated by a 27-aa linker, sharing 16/24 identical anchors (including KPKR, PNT, LS, and SYE) plus conservative basic (+) and aliphatic (ψ) substitutions.","i":[[1293,1316,"RKQPPPKPKRDPNTRLSASYEAVS"],[1344,1367,"KKIPPRKPKRSPNTKLSGSYEEIS"]]},{"c":"P[PK][AI]PY[SR]P","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed copies in the C-terminal proline/serine-rich disordered region anchored by invariant P1, P4, Y5, and P7 positions alongside constrained internal [PK], [AI], and [SR] choices.","i":[[1583,1589,"PPAPYRP"],[1633,1639,"PKIPYSP"],[1656,1662,"PPAPYSP"]]}],"s":"MEIDQCLLESLPLGQRQRLVKRMRCEQIKAYYEREKAFQKQEGFLKRLKHAKNPKVHFNLTDMLQDAIIHHNDKEVLRLLKEGADPHTLVSSGGSLLHLCARYDNAFIAEILIDRGVNVNHQDEDFWTPMHIACACDNPDIVLLLVLAGANVLLQDVNGNIPLDYAVEGTESSSILLTYLDENGVDLTSLRQMKLQRPMSMLTDVKHFLSSGGNVNEKNDEGVTLLHMACASGYKEVVSLILEHGGDLNIVDDQYWTPLHLAAKYGQTNLVKLLLMHQANPHLVNCNEEKASDIAASEFIEEMLLKAEIAWEEKMKEPLSASTLAQEEPYEEIIHDLPVLSSKLSPLVLPIAKQDSLLEKDIMFKDATKGLCKQQSQDSIPENPMMSGSTKPEQVKLMPPAPNDDLATLSELNDGSLLYEIQKRFGNNQIYTFIGDILLLVNPYKELPIYSSMVSQLYFSSSGKLCSSLPPHLFSCVERAFHQLFREQRPQCFILSGERGSGKSEASKQIIRHLTCRAGASRATLDSRFKHVVCILEAFGHAKTTLNDLSSCFIKYFELQFCERKQQLTGARIYTYLLEKSRLVSQPLGQSNFLIFYLLMDGLSAEEKYGLHLNNLCAHRYLNQTIQDDASTGERSLNREKLAVLKRALNVVGFSSLEVENLFVILAAILHLGDIRFTALNEGNSAFVSDLQLLEQVAGMLQVSTDELASALTTDIQYFKGDMIIRRHTIQIAEFFRDLLAKSLYSRLFSFLVNTMNSCLHSQDEQKSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLHEQVECVQEGVTMETAYSPGNQNGVLDFFFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLLESSNTNAVYSPMKDGNGNVALKDHGTAFTIMHYAGRVMYDVVGAIEKNKDSLSQNLLFVMKTSENVVINHLFQSKLSQTGSLVSAYPSFKFRGHKSALLSKKMTASSIIGENKNYLELSKLLKKKGTSTFLQRLERGDPVTIASQLRKSLMDIIGKLQKCTPHFIHCIRPNNSKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPVRLSFSDFLSRYKPLADTFLREKKEQSAAERCRLVLQQCKLQGWQMGVRKVFLKYWHADQLNDLCLQLQRKIITCQKVIRGFLARQHLLQRISIRQQEVTSINSFLQNTEDMGLKTYDALVIQNASDIARENDRLRSEMNAPYHKEKLEVRNMQEEGSKRTDDKSGPRHFHPSSMSVCAAVDGLGQCLVGPSIWSPSLHSVFSMDDSSSLPSPRKQPPPKPKRDPNTRLSASYEAVSACLSAAREAANEALARPRPHSDDYSTMKKIPPRKPKRSPNTKLSGSYEEISGSRPGDARPAGAPGAAARVLTPGTPQCALPPAAPPGDEDDSEPVYIEMLGHAARPDSPDPGESVYEEMKCCLPDDGGPGAGSFLLHGASPPLLHRAPEDEAAGPPGDACDIPPPFPNLLPHRPPLLVFPPTPVTCSPASDESPLTPLEVKKLPVLETNLKYPVQPEGSSPLSPQYSKSQKGDGDRPASPGLALFNGSGRASPPSTPPPPPPPPGPPPAPYRPCAHLAFPPEPAPVNAGKAGPSAEAPKVHPKPNSAPVAGPCSSFPKIPYSPVKATRADARKAGSSASPPAPYSPPSSRPLSSPLDELASLFNSGRSVLRKSAAGRKIREAEGFETNMNISSRDDPSTSEITSETQDRNANNHGIQLSNSLSSAITAENGNSISNGLPEEDGYSRLSISGTGTSTFQRHRDSHTTQVIHQLRLSENESVALQELLDWRRKLCEEGQDWQQILHHAEPRVPPPPPCKKPSLLKKPEGASCNRLPSELWDTTI"},{"id":"SEQ_02898","a":"P42566","g":"EPS15","d":"Epidermal growth factor receptor substrate 15","L":896,"m":[{"c":"Y-xφΩxxx(x){4,5}G[RF]ψ[LS][AG]xxφxxφφ[KL][KN][ST][GK]LPxxψL[GA][KRH]ψWxLxD[TI][DK]xxGxLx+[QD][EQ]F[FA]ψAφxLψx[CQ][AK][QL](x){13,14}ψPP","u":"81-83","sp":"dispersed","x":"structured_like","cf":"high","why":"Three highly conserved ~82-aa globular N-terminal domain repeats anchored by N-terminal Y-xφΩ, central LPxxψL..W..LxD..G.L.+..F..A..L core, and a C-terminal ψPP clamp, separated by 20-30 aa linkers.","i":[[19,100,"YEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPP"],[132,212,"YDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPP"],[228,310,"YDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPP"]]},{"c":"xDPFx","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Fifteen non-overlapping 5-aa repeats distributed across the C-terminal disordered region (residues 598-828), anchored by an invariant DPF tripeptide core with predominantly small/polar/acidic -1 (S/T/N/E/D) and small/basic +1 (A/K/R/G) flanking residues.","i":[[598,602,"EDPFN"],[622,626,"SDPFV"],[628,632,"SDPFK"],[633,637,"DDPFG"],[639,643,"IDPFG"],[644,648,"GDPFK"],[650,654,"SDPFA"],[663,667,"TDPFA"],[671,675,"TDPFS"],[691,695,"NDPFA"],[708,712,"TDPFA"],[736,740,"EDPFR"],[797,801,"PDPFK"],[803,807,"NDPFQ"],[824,828,"CDPFT"]]}],"s":"MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFRQSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESFGGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADPSNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA"},{"id":"SEQ_02906","a":"Q9NZM1","g":"MYOF","d":"Myoferlin","L":2061,"m":[{"c":"[DR][PI]φφx[VIG]xφ(x){13,21}N[PF]xΩxxxφxφx(x){8,29}ψxψxψx[DN]x[DEH]xφxx[ND]xxψGxxxφx[LPV]","u":"66-93","sp":"dispersed","x":"structured_like","cf":"high","why":"Six dispersed ~66-93 aa structured domain repeats sharing three conserved hydrophobic/polar blocks—an N-terminal [DR][PI]φφx[VIG]xφ motif, a central N[PF]xΩxxxφxφx motif, and a C-terminal ψxψxψ..[DN]x[DEH]..ψGxxxφ motif—separated by two variable-length internal loops.","i":[[21,88,"DPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLDFSSSLGIIVKDFETIGQNKLIGTATVAL"],[217,284,"RPVVKVHVCGQTHRTRIKRGNNPFFDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDV"],[396,461,"DPFVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHL"],[1161,1234,"DPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSP"],[1575,1641,"DPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDL"],[1814,1906,"DIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDL"]]},{"c":"[PEQ][KPE]GWE[WY][EGA]xxφ","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed 10-aa repeats in the central polar/charged disordered linker (residues 902-1057) anchored by an invariant GWE[WY] aromatic-acidic core with conserved N-terminal [PEQ][KPE] and C-terminal hydrophobic positions.","i":[[902,911,"PKGWEWEGEW"],[970,979,"PPGWEWEDDA"],[990,999,"EKGWEYGITI"],[1048,1057,"QEGWEYASLI"]]}],"s":"MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLDFSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDLVIGYDPPSAPHPNDLSGPSVPGMGGDGEEDEGDEDRLDNAVRGPGPKGPVGTVSEAQLARRLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTFLLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEDFSSSGTGAASYTVNTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIGNYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQALMFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDKAASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGKDGSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQLKASLLSAPPCRDIVIEMEDTKPLLASKLTEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDTFKLYRGKSDENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIVKPNV"},{"id":"SEQ_02907","a":"Q9Y5W3","g":"KLF2","d":"Krueppel-like factor 2","L":355,"m":[{"c":"[HYF][THQ]C(x){2,4}C[GD][KWR][TKA]Ω[TAS]+S[SD][HE]L[KTA][ARL]Hφ+[TKR]H[TM]","u":"24-26","sp":"periodic","x":"structured_like","cf":"high","why":"Three C-terminal 24-26 aa structured repeats separated by regular 4-aa G[EH][KR]P linkers, defined by invariant Cys2/His2 pairs (Cx2-4C...Hx3H) together with conserved aromatic (Ω), basic (+), serine, and leucine positions.","i":[[272,297,"HTCSYAGCGKTYTKSSHLKAHLRTHT"],[302,327,"YHCNWDGCGWKFARSDELTRHYRKHT"],[332,355,"FQCHLCDRAFSRSDHLALHMKRHM"]]}],"s":"MALSEPILPSFSTFASPCRERGLQERWPRAEPESGGTDDDLNSVLDFILSMGLDGLGAEAAPEPPPPPPPPAFYYPEPGAPPPYSAPAGGLVSELLRPELDAPLGPALHGRFLLAPPGRLVKAEPPEADGGGGYGCAPGLTRGPRGLKREGAPGPAASCMRGPGGRPPPPPDTPPLSPDGPARLPAPGPRASFPPPFGGPGFGAPGPGLHYAPPAPPAFGLFDDAAAAAAALGLAPPAARGLLTPPASPLELLEAKPKRGRRSWPRKRTATHTCSYAGCGKTYTKSSHLKAHLRTHTGEKPYHCNWDGCGWKFARSDELTRHYRKHTGHRPFQCHLCDRAFSRSDHLALHMKRHM"},{"id":"SEQ_02917","a":"Q02446","g":"SP4","d":"Transcription factor Sp4","L":784,"m":[{"c":"[HF][IE]C(x){2,4}C[GS]K[VR]Ωx+[TS][SD][HE]LxxHx+xH[TQ]","u":"24-26","sp":"periodic","x":"structured_like","cf":"high","why":"Three C2H2-type zinc-finger repeats anchored by invariant Cys2/His2 metal-coordinating pairs, a conserved K[VR]Ω aromatic-basic motif, and an internal L residue, separated by regular 4-residue GE+[PR] linkers.","i":[[647,672,"HICHIEGCGKVYGKTSHLRAHLRWHT"],[677,702,"FICNWMFCGKRFTRSDELQRHRRTHT"],[707,730,"FECPECSKRFMRSDHLSKHVKTHQ"]]}],"s":"MSDQKKEEEEEAAAAAAMATEGGKTSEPENNNKKPKTSGSQDSQPSPLALLAATCSKIGTPGENQATGQQQIIIDPSQGLVQLQNQPQQLELVTTQLAGNAWQLVASTPPASKENNVSQPASSSSSSSSSNNGSASPTKTKSGNSSTPGQFQVIQVQNPSGSVQYQVIPQLQTVEGQQIQINPTSSSSLQDLQGQIQLISAGNNQAILTAANRTASGNILAQNLANQTVPVQIRPGVSIPLQLQTLPGTQAQVVTTLPINIGGVTLALPVINNVAAGGGTGQVGQPAATADSGTSNGNQLVSTPTNTTTSASTMPESPSSSTTCTTTASTSLTSSDTLVSSADTGQYASTSASSSERTIEESQTPAATESEAQSSSQLQPNGMQNAQDQSNSLQQVQIVGQPILQQIQIQQPQQQIIQAIPPQSFQLQSGQTIQTIQQQPLQNVQLQAVNPTQVLIRAPTLTPSGQISWQTVQVQNIQSLSNLQVQNAGLSQQLTITPVSSSGGTTLAQIAPVAVAGAPITLNTAQLASVPNLQTVSVANLGAAGVQVQGVPVTITSVAGQQQGQDGVKVQQATIAPVTVAVGGIANATIGAVSPDQLTQVHLQQGQQTSDQEVQPGKRLRRVACSCPNCREGEGRGSNEPGKKKQHICHIEGCGKVYGKTSHLRAHLRWHTGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDHLSKHVKTHQNKKGGGTALAIVTSGELDSSVTEVLGSPRIVTVAAISQDSNPATPNVSTNMEEF"},{"id":"SEQ_02929","a":"P15407","g":"FOSL1","d":"Fos-related antigen 1","L":271,"m":[{"c":"TP[TS]L[MTV]","u":5,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Three closely spaced tandem copies in the C-terminal Pro/Ser/Thr-rich disordered tail anchored by invariant TP and L positions (separated by 1-2 residue gaps, with a related SPTLL copy further C-terminal).","i":[[217,221,"TPTLM"],[223,227,"TPSLT"],[230,234,"TPSLV"]]}],"s":"MFRDFGEPGPSSGNGGGYGGPAQPPAAAQAAQQKFHLVPSINTMSGSQELQWMVQPHFLGPSSYPRPLTYPQYSPPQPRPGVIRALGPPPGVRRRPCEQISPEEEERRRVRRERNKLAAAKCRNRRKELTDFLQAETDKLEDEKSGLQREIEELQKQKERLELVLEAHRPICKIPEGAKEGDTGSTSGTSSPPAPCRPVPCISLSPGPVLEPEALHTPTLMTTPSLTPFTPSLVFTYPSTPEPCASAHRKSSSSSGDPSSDPLGSPTLLAL"},{"id":"SEQ_02937","a":"P0CW27","g":"CCDC166","d":"Coiled-coil domain-containing protein 166","L":439,"m":[{"c":"S[RKS]x[ADG][SP][RQ]x[PSL]S[LV][VAT]x","u":12,"sp":"tandem","x":"disordered_like","cf":"high","why":"Six head-to-tail 12-residue tandem repeats in the C-terminal disordered region anchored by two invariant S positions (pos 1 and 9), conserved SR-like dyads, and a C-terminal S[LV][VAT] hydrophobic patch.","i":[[304,315,"SRAASQTPSVVP"],[316,327,"SRAAPRASSVVP"],[328,339,"SREASRVPSLVL"],[340,351,"SSMDSRVPSLAT"],[352,363,"SKVGSRMPSLTA"],[364,375,"SRAGSRALSLVQ"]]}],"s":"MAPKKKRGPSAGSQPGGAAAAGAEQPLSERAQYLQREHALLSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCAKAIVRLDEQNRVDLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRALERELLHMRVEHTQLLHRVKRRFLEDKAAFEREARQRVQSLARRAEREAVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLHREHEDTRDLARVHGWLRRGPGGPPLWERPAFSQPTSRPGSLAAPISPSRAASQTPSVVPSRAAPRASSVVPSREASRVPSLVLSSMDSRVPSLATSKVGSRMPSLTASRAGSRALSLVQSLEGSGISSGSSPRVSSQDTLRSTKSGPKLLSGLSRDRDPALLPPQSEDSVNAEAAAEASPGRA"},{"id":"SEQ_02952","a":"Q9UIU6","g":"SIX4","d":"Homeobox protein SIX4","L":781,"m":[{"c":"S[GP]VφLNGxx[VF]","u":10,"sp":"periodic","x":"disordered_like","cf":"high","why":"Three periodic 10-aa repeats separated by uniform 4-aa linkers in the C-terminal disordered region, anchored by invariant S, V, and LNG positions plus conserved [GP], bulky hydrophobic φ (L/F/I), and C-terminal [VF] residues (with a degenerate FLNG echo further downstream).","i":[[346,355,"SGVLLNGSLV"],[360,369,"SPVFLNGNSF"],[374,383,"SGVILNGLNV"]]}],"s":"MSSSSPTGQIASAADIKQENGMESASEGQEAHREVAGGAAVGLSPPAPAPFPLEPGDAATAAARVSGEEGAVAAAAAGAAADQVQLHSELLGRHHHAAAAAAQTPLAFSPDHVACVCEALQQGGNLDRLARFLWSLPQSDLLRGNESLLKARALVAFHQGIYPELYSILESHSFESANHPLLQQLWYKARYTEAERARGRPLGAVDKYRLRRKFPLPRTIWDGEETVYCFKEKSRNALKELYKQNRYPSPAEKRHLAKITGLSLTQVSNWFKNRRQRDRNPSETQSKSESDGNPSTEDESSKGHEDLSPHPLSSSSDGITNLSLSSHMEPVYMQQIGNAKISLSSSGVLLNGSLVPASTSPVFLNGNSFIQGPSGVILNGLNVGNTQAVALNPPKMSSNIVSNGISMTDILGSTSQDVKEFKVLQSSANSATTTSYSPSVPVSFPGLIPSTEVKREGIQTVASQDGGSVVTFTTPVQINQYGIVQIPNSGANSQFLNGSIGFSPLQLPPVSVAASQGNISVSSSTSDGSTFTSESTTVQQGKVFLSSLAPSAVVYTVPNTGQTIGSVKQEGLERSLVFSQLMPVNQNAQVNANLSSENISGSGLHPLASSLVNVSPTHNFSLSPSTLLNPTELNRDIADSQPMSAPVASKSTVTSVSNTNYATLQNCSLITGQDLLSVPMTQAALGEIVPTAEDQVGHPSPAVHQDFVQEHRLVLQSVANMKENFLSNSESKATSSLMMLDSKSKYVLDGMVDTVCEDLETDKKELAKLQTVQLDEDMQDL"},{"id":"SEQ_02961","a":"A6NN90","g":"C2orf81","d":"Uncharacterized protein C2orf81","L":582,"m":[{"c":"-SWxxxxxxxψxxxxxxxxExFQxxxPGG","u":29,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Two-copy 29-aa internal duplication in the central P/S/E-rich disordered region (residues 129-157 and 177-205, separated by 19 aa) anchored at identical ungapped register by an N-terminal acidic-SW motif (-SW), an internal aliphatic residue (L/V), and a conserved C-terminal ExFQxxxPGG motif.","i":[[129,157,"DSWAQGSVPVLHASTSEGLENFQGEDPGG"],[177,205,"ESWEPSPQLRVTSAPPPTSELFQEAGPGG"]]}],"s":"MAHEGSRQVRDRGVTRSKAEKVRPPTVPVPQVDIVPGRLSEAEWMALTALEEGEDVVGDILADLLARVMDSAFKVYLTQQCIPFTISQAREAMLQITEWRFLARDEGESAVAEDPTWGEDEEPSACTTDSWAQGSVPVLHASTSEGLENFQGEDPGGVDRIPLGRSWMGRGSQEQMESWEPSPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSSAGSLSASFQLSVEEAPADDADPSLDPYLVASPQASTGRGHPLGFHLSLEDLYCCMPQLDAAGDRLELRSEGVPCIASGVLVSYPSVGGATRPSASCQQQRAGHSDVRLSAHHHRMRRKAAVKRLDPARLPCHWVRPLAEVLVPDSQTRPLEAYRGRQRGEKTKARAEPQALGPGTRVSPAAFFPLRPGIPFRDLDSGPALLFPTLNLGLSSPSLESKLPLPNSRIRFLTTHPVLPDVARSRSPKLWPSVRWPSGWEGKAELLGELWAGRTRVPPQGLELADREGQDPGRWPRTTPPVLEATSQVMWKPVLLPEALKLAPGVSMWNRSTQVLLSSGVPEQEDKEGSTFPPVEQHPIQTGAPKPR"},{"id":"SEQ_02962","a":"Q6IMN6","g":"CAPRIN2","d":"Caprin-2","L":1127,"m":[{"c":"[EQS][EQ]xKQ-[STI][SPF]K","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five dispersed 9-aa copies within the central polar/charged disordered region (residues 413-495) anchored by invariant K4, Q5, acidic [DE]6, and C-terminal K9 positions with conserved N-terminal polar/acidic and C-terminal [STI][SPF] positions.","i":[[413,421,"QEKKQESFK"],[440,448,"EQRKQDTSK"],[456,464,"EQKKQEISK"],[470,478,"SQWKQDTPK"],[487,495,"EQKKQETPK"]]},{"c":"[TS][PT]KSW","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed 5-aa copies immediately downstream in the same disordered region (residues 511-570), tightly anchored by an invariant KSW tripeptide preceded by [TS][PT] separated by 9-17 aa polar linkers.","i":[[511,515,"TPKSW"],[525,529,"TTKSW"],[544,548,"TPKSW"],[566,570,"SPKSW"]]}],"s":"MEVQVSQASLGFELTSVEKSLREWSRLSREVIAWLCPSSPNFILNFPPPPSASSVSMVQLFSSPFGYQSPSGHSEEEREGNMKSAKPQVNHSQHGESQRALSPLQSTLSSAASPSQAYETYIENGLICLKHKIRNIEKKKLKLEDYKDRLKSGEHLNPDQLEAVEKYEEVLHNLEFAKELQKTFSGLSLDLLKAQKKAQRREHMLKLEAEKKKLRTILQVQYVLQNLTQEHVQKDFKGGLNGAVYLPSKELDYLIKFSKLTCPERNESLSVEDQMEQSSLYFWDLLEGSEKAVVGTTYKHLKDLLSKLLNSGYFESIPVPKNAKEKEVPLEEEMLIQSEKKTQLSKTESVKESESLMEFAQPEIQPQEFLNRRYMTEVDYSNKQGEEQPWEADYARKPNLPKRWDMLTEPDGQEKKQESFKSWEASGKHQEVSKPAVSLEQRKQDTSKLRSTLPEEQKKQEISKSKPSPSQWKQDTPKSKAGYVQEEQKKQETPKLWPVQLQKEQDPKKQTPKSWTPSMQSEQNTTKSWTTPMCEEQDSKQPETPKSWENNVESQKHSLTSQSQISPKSWGVATASLIPNDQLLPRKLNTEPKDVPKPVHQPVGSSSTLPKDPVLRKEKLQDLMTQIQGTCNFMQESVLDFDKPSSAIPTSQPPSATPGSPVASKEQNLSSQSDFLQEPLQATSSPVTCSSNACLVTTDQASSGSETEFMTSETPEAAIPPGKQPSSLASPNPPMAKGSEQGFQSPPASSSSVTINTAPFQAMQTVFNVNAPLPPRKEQEIKESPYSPGYNQSFTTASTQTPPQCQLPSIHVEQTVHSQETAANYHPDGTIQVSNGSLAFYPAQTNVFPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGYKGFDTYRGLPSISNGNYSQLQFQAREYSGAPYSQRDNFQQCYKRGGTSGGPRANSRAGWSDSSQVSSPERDNETFNSGDSGQGDSRSMTPVDVPVTNPAATILPVHVYPLPQQMRVAFSAARTSNLAPGTLDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAVNVPLYVNLMKNEEVLVSAYANDGAPDHETASNHAILQLFQGDQIWLRLHRGAIYGSSWKYSTFSGYLLYQD"},{"id":"SEQ_02967","a":"Q9UPX8","g":"SHANK2","d":"SH3 and multiple ankyrin repeat domains protein 2","L":1849,"m":[{"c":"[GS]x[TH][PAE]φxx[ATC][ACI]xφxxxxxxxxφ[LK](x){2,3}[GHK][AGE]xxxxxxxx","u":"33-34","sp":"tandem","x":"structured_like","cf":"high","why":"Six contiguous head-to-tail 33-34 aa repeats in the N-terminal structured region anchored by an N-terminal [GS]x[TH][PAE]φxx[ATC][ACI]xφ motif, a second conserved hydrophobic core (φ[LK]), and a [GHK][AGE] turn.","i":[[197,230,"GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKD"],[231,263,"GMTALHKAARARNQVALKTLLELGASPDYKDSY"],[264,297,"GLTPLYHTAIVGGDPYCCELLLHEHATVCCKDEN"],[298,330,"GWHEIHQACRYGHVQHLEHLLFYGADMSAQNAS"],[331,363,"GNTALHICALYNQDSCARVLLFRGGNKELKNYN"],[364,396,"SQTPFQVAIIAGNFELAEYIKNHKETDIVPFRE"]]}],"s":"MPRSPTSSEDEMAQSFSDYSVGSESDSSKEETIYDTIRATAEKPGGARTEESQGNTLVIRVVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGKFLDEERLLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNHKETDIVPFREAPAYSNRRRRPPNTLAAPRVLLRSNSDNNLNASAPDWAVCSTATSHRSLSPQLLQQMPSKPEGAAKTIGSYVPGPRSRSPSLNRLGGAGEDGKRPQPLWHVGSPFALGANKDSLSAFEYPGPKRKLYSAVPGRLFVAVKPYQPQVDGEIPLHRGDRVKVLSIGEGGFWEGSARGHIGWFPAECVEEVQCKPRDSQAETRADRSKKLFRHYTVGSYDSFDTSSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDDTARKKAPPPPKRAPTTALTLRSKSMTSELEELVDKASVRKKKDKPEEIVPASKPSRAAENMAVEPRVATIKQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSPKAPFLGIPRGTMRRQKSIDSRIFLSGITEEERQFLAPPMLKFTRSLSMPDTSEDIPPPPQSVPPSPPPPSPTTYNCPKSPTPRVYGTIKPAFNQNSAAKVSPATRSDTVATMMREKGMYFRRELDRYSLDSEDLYSRNAGPQANFRNKRGQMPENPYSEVGKIASKAVYVPAKPARRKGMLVKQSNVEDSPEKTCSIPIPTIIVKEPSTSSSGKSSQGSSMEIDPQAPEPPSQLRPDESLTVSSPFAAAIAGAVRDREKRLEARRNSPAFLSTDLGDEDVGLGPPAPRTRPSMFPEEGDFADEDSAEQLSSPMPSATPREPENHFVGGAEASAPGEAGRPLNSTSKAQGPESSPAVPSASSGTAGPGNYVHPLTGRLLDPSSPLALALSARDRAMKESQQGPKGEAPKADLNKPLYIDTKMRPSLDAGFPTVTRQNTRGPLRRQETENKYETDLGRDRKGDDKKNMLIDIMDTSQQKSAGLLMVHTVDATKLDNALQEEDEKAEVEMKPDSSPSEVPEGVSETEGALQISAAPEPTTVPGRTIVAVGSMEEAVILPFRIPPPPLASVDLDEDFIFTEPLPPPLEFANSFDIPDDRAASVPALSDLVKQKKSDTPQSPSLNSSQPTNSADSKKPASLSNCLPASFLPPPESFDAVADSGIEEVDSRSSSDHHLETTSTISTVSSISTLSSEGGENVDTCTVYADGQAFMVDKPPVPPKPKMKPIIHKSNALYQDALVEEDVDSFVIPPPAPPPPPGSAQPGMAKVLQPRTSKLWGDVTEIKSPILSGPKANVISELNSILQQMNREKLAKPGEGLDSPMGAKSASLAPRSPEIMSTISGTRSTTVTFTVRPGTSQPITLQSRPPDYESRTSGTRRAPSPVVSPTEMNKETLPAPLSAATASPSPALSDVFSLPSQPPSGDLFGLNPAGRSRSPSPSILQQPISNKPFTTKPVHLWTKPDVADWLESLNLGEHKEAFMDNEIDGSHLPNLQKEDLIDLGVTRVGHRMNIERALKQLLDR"},{"id":"SEQ_02975","a":"Q86YR6","g":"POTED","d":"POTE ankyrin domain family member D","L":584,"m":[{"c":"LRSKMGK[WC]C[HRC]H[RC]FPCCRGSG[KT]SN[MV]G[TA][SW]GD[HY]-[DNH]S(x){0,1}FM[KE]","u":"36-37","sp":"tandem","x":"structured_like","cf":"high","why":"Three tandem 36-37 aa repeats (separated by single-residue M linkers) with invariant LRSKMGK, FPCCRGSG, SN, G, GD, S, and FM anchors plus conserved cysteine pairs and a 1-residue insertion before FM in the third copy.","i":[[20,55,"LRSKMGKWCHHRFPCCRGSGKSNMGTSGDHDDSFMK"],[57,92,"LRSKMGKCCRHCFPCCRGSGTSNVGTSGDHENSFMK"],[94,130,"LRSKMGKWCCHCFPCCRGSGKSNVGAWGDYDHSAFME"]]},{"c":"xx[KG]xT[AP]L[HLI]x[AG][SIV]xx[GQE]xxxx[VA]xφL[LI]xxx[CAV][DNQ]x[NES][VIS]x[DN]","u":33,"sp":"tandem","x":"structured_like","cf":"high","why":"Five contiguous head-to-tail 33-aa structured repeats anchored by T[AP]L[HLI]x[AG], a hydrophobic helix core ([VA]xφL[LI]), and a C-terminal [DN] turn residue, flanked by degenerate N- and C-terminal capping repeats (residues 140-169 and 335-360).","i":[[171,203,"KEKRTALHLASANGNSEVVQLLLDRRCQLNVLD"],[204,236,"NKKRTALIKAIQCQEDECVLMLLEHGADRNIPD"],[237,269,"EYGNTALHYAIYNEDKLMAKALLLYGADIESKN"],[270,302,"KCGLTPLLLGVHEQKQQVVKFLIKKKANLNVLD"],[303,335,"RYGRTALILAVCCGSASIVNLLLEQNVDVSSQD"]]}],"s":"MVAEVCSMPTASTVKKPFDLRSKMGKWCHHRFPCCRGSGKSNMGTSGDHDDSFMKMLRSKMGKCCRHCFPCCRGSGTSNVGTSGDHENSFMKMLRSKMGKWCCHCFPCCRGSGKSNVGAWGDYDHSAFMEPRYHIRREDLDKLHRAAWWGKVPRKDLIVMLRDTDMNKRDKEKRTALHLASANGNSEVVQLLLDRRCQLNVLDNKKRTALIKAIQCQEDECVLMLLEHGADRNIPDEYGNTALHYAIYNEDKLMAKALLLYGADIESKNKCGLTPLLLGVHEQKQQVVKFLIKKKANLNVLDRYGRTALILAVCCGSASIVNLLLEQNVDVSSQDLSGQTAREYAVSSHHHVICELLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRLKVSENSQPEKMSQEPEINKDCDREVEEEIKKHGSNPVGLPENLTNGASAGNGDDGLIPQRRSRKPENQQFPDTENEEYHSDEQNDTRKQLSEEQNTGISQDEILTNKQKQIEVAEQKMNSELSLSHKKEEDLLRENSVLQEEIAMLRLELDETKHQNQLRENKILEEIESVKEKTDKLLRAMQLNEEALTKTNI"},{"id":"SEQ_02984","a":"Q8N7P7","g":"YH007_HUMAN","d":"Uncharacterized protein FLJ40521","L":452,"m":[{"c":"TAVSS[NK]R[ND][PH][EKG][DNE]DGCLL[KE]Q[EG][PS]RGRRLS[PS][QRL]TG[TAI][PT][GR]T","u":34,"sp":"tandem","x":"mixed","cf":"high","why":"Twelve highly conserved 34-aa tandem repeats spanning nearly the entire protein with invariant TAVSS, R, DGCLL, Q, RGRRLS, and TG anchors, interrupted once by an 11-aa partial duplication (376-386) and followed by a 20-aa C-terminal partial copy (421-440).","i":[[2,35,"TAVSSNRNPEDDGCLLEQEPRGRRLSPRTGTPRT"],[36,69,"TAVSSNRDPKNDGCLLKQEPRGRRLSPRTGAPGT"],[70,103,"TAVSSNRNPEDDGCLLKQEPRGRRLSPQTGTPRT"],[104,137,"TAVSSNRNPGDDGCLLKQGPRGRRLSPQTGTPGT"],[138,171,"TAVSSNRNPEDDGCLLKQEPRGRRLSPQTGTPGT"],[172,205,"TAVSSNRDHEDDGCLLKQESRGRRLSPQTGTPGT"],[206,239,"TAVSSNRNPEDDGCLLKQESRGRRLSPQTGTPGT"],[240,273,"TAVSSNRDPEDDGCLLKQGPRGRRLSPQTGTPRT"],[274,307,"TAVSSNRNPEDDGCLLKQGPRGRRLSPQTGIPRT"],[308,341,"TAVSSNRDPGEDGCLLKQESRGRRLSPQTGTTRT"],[342,375,"TAVSSKRNPEDDGCLLKQEPRGRRLSSLTGAPGT"],[387,420,"TAVSSNRNPGDDGCLLKQGPRGRRLSPQTGTPGT"]]}],"s":"MTAVSSNRNPEDDGCLLEQEPRGRRLSPRTGTPRTTAVSSNRDPKNDGCLLKQEPRGRRLSPRTGAPGTTAVSSNRNPEDDGCLLKQEPRGRRLSPQTGTPRTTAVSSNRNPGDDGCLLKQGPRGRRLSPQTGTPGTTAVSSNRNPEDDGCLLKQEPRGRRLSPQTGTPGTTAVSSNRDHEDDGCLLKQESRGRRLSPQTGTPGTTAVSSNRNPEDDGCLLKQESRGRRLSPQTGTPGTTAVSSNRDPEDDGCLLKQGPRGRRLSPQTGTPRTTAVSSNRNPEDDGCLLKQGPRGRRLSPQTGIPRTTAVSSNRDPGEDGCLLKQESRGRRLSPQTGTTRTTAVSSKRNPEDDGCLLKQEPRGRRLSSLTGAPGTTAVSSNRDPRTTAVSSNRNPGDDGCLLKQGPRGRRLSPQTGTPGTTAVSSNRDPEDDGCLLKQEPQELRKPEADTAL"},{"id":"SEQ_03005","a":"Q7Z5K2","g":"WAPL","d":"Wings apart-like protein homolog","L":1190,"m":[{"c":"[PFY]FGF-[DS]","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed copies in acidic/polar disordered regions share an invariant FGF aromatic-glycine core flanked by an N-terminal [PFY] residue and a C-terminal acidic -[DS] dyad, embedded within broader D/E/S-rich acidic patches.","i":[[72,77,"PFGFDS"],[428,433,"FFGFED"],[452,457,"YFGFDD"]]}],"s":"MTSRFGKTYSRKGGNGSSKFDEVFSNKRTTLSTKWGETTFMAKLGQKRPNFKPDIQEIPKKPKVEEESTGDPFGFDSDDESLPVSSKNLAQVKCSSYSESSEAAQLEEVTSVLEANSKISHVVVEDTVVSDKCFPLEDTLLGKEKSTNRIVEDDASISSCNKLITSDKVENFHEEHEKNSHHIHKNADDSTKKPNAETTVASEIKETNDTWNSQFGKRPESPSEISPIKGSVRTGLFEWDNDFEDIRSEDCILSLDSDPLLEMKDDDFKNRLENLNEAIEEDIVQSVLRPTNCRTYCRANKTKSSQGASNFDKLMDGTSQALAKANSESSKDGLNQAKKGGVSCGTSFRGTVGRTRDYTVLHPSCLSVCNVTIQDTMERSMDEFTASTPADLGEAGRLRKKADIATSKTTTRFRPSNTKSKKDVKLEFFGFEDHETGGDEGGSGSSNYKIKYFGFDDLSESEDDEDDDCQVERKTSKKRTKTAPSPSLQPPPESNDNSQDSQSGTNNAENLDFTEDLPGVPESVKKPINKQGDKSKENTRKIFSGPKRSPTKAVYNARHWNHPDSEELPGPPVVKPQSVTVRLSSKEPNQKDDGVFKAPAPPSKVIKTVTIPTQPYQDIVTALKCRREDKELYTVVQHVKHFNDVVEFGENQEFTDDIEYLLSGLKSTQPLNTRCLSVISLATKCAMPSFRMHLRAHGMVAMVFKTLDDSQHHQNLSLCTAALMYILSRDRLNMDLDRASLDLMIRLLELEQDASSAKLLNEKDMNKIKEKIRRLCETVHNKHLDLENITTGHLAMETLLSLTSKRAGDWFKEELRLLGGLDHIVDKVKECVDHLSRDEDEEKLVASLWGAERCLRVLESVTVHNPENQSYLIAYKDSQLIVSSAKALQHCEELIQQYNRAEDSICLADSKPLPHQNVTNHVGKAVEDCMRAIIGVLLNLTNDNEWGSTKTGEQDGLIGTALNCVLQVPKYLPQEQRFDIRVLGLGLLINLVEYSARNRHCLVNMETSCSFDSSICSGEGDDSLRIGGQVHAVQALVQLFLERERAAQLAESKTDELIKDAPTTQHDKSGEWQETSGEIQWVSTEKTDGTEEKHKKEEEDEELDLNKALQHAGKHMEDCIVASYTALLLGCLCQESPINVTTVREYLPEGDFSIMTEMLKKFLSFMNLTCAVGTTGQKSISRVIEYLEHC"},{"id":"SEQ_03011","a":"Q13283","g":"G3BP1","d":"Ras GTPase-activating protein-binding protein 1","L":466,"m":[{"c":"[DNQ]I[EP]P[QR]RxxR","u":9,"sp":"periodic","x":"disordered_like","cf":"high","why":"Three periodic 9-aa copies separated by exact 9-aa linkers (18-residue period) in the central disordered linker, anchored by invariant I2, P4, R6, and R9 alongside conserved [DNQ]1, [EP]3, and [QR]5 positions.","i":[[291,299,"QIPPQRPQR"],[309,317,"NIPPQRGPR"],[327,335,"DIEPRRMVR"]]},{"c":"EPV[ASL]E","u":5,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 5-aa copies in the acidic E/P-rich disordered region anchored by invariant E1, P2, hydrophobic V3 (the only valines in this 60-aa region), and E5.","i":[[189,193,"EPVAE"],[205,209,"EPVSE"],[216,220,"EPVLE"]]}],"s":"MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKEIHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSVANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQAVVSNDMEEHLEEPVAEPEPDPEPEPEQEPVSEIQEEKPEPVLEETAPEDAQKSSSPAPADIAQTVQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPPQRPQRDQRVREQRINIPPQRGPRPIREAGEQGDIEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFFQSYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAAREGDRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRGLAPRQ"},{"id":"SEQ_03017","a":"Q96C12","g":"ARMC5","d":"Armadillo repeat-containing protein 5","L":935,"m":[{"c":"xxxxx[AI][LV]xxxxx(x){14,19}[PLV]Lφxxxxx","u":"34-39","sp":"dispersed","x":"structured_like","cf":"high","why":"Nine helical repeats (seven arranged in a central tandem array from residues 127-421 flanked by two dispersed copies at residues 39-77 and 653-690) sharing a conserved [AI][LV]xxL N-terminal helix, a variable inter-helical loop ending in an invariant Gφ turn, and a [PLV]LφxxL C-terminal helix.","i":[[38,76,"TPLSRALLALRTRHIKAAGGIERFRARGGLRPLLALLRR"],[127,164,"KTLDLALSILADCCTEGACRTEVRRLGGILPLVTILQC"],[172,205,"NRTARALGNLAMEPESCGDIHCAGAVPLLVESLT"],[214,248,"QSVVRALRNLADSPQHRLALAQQGAVRPLAELLAT"],[256,292,"LALVRALLELSRGCSRACAEQLSLGGGLGPLVSLASH"],[299,333,"EGTILILANLCAQGLIRPALGNAGGVEVLVDELRQ"],[346,380,"QPLVRAVCLLCREAINRARLRDAGGLDLLMGLLRD"],[388,421,"PRIVAALVGFLYDTGALGRLQALGLVPLLAGQLC"],[653,690,"DRVACALTLPFICRKPSLWRRLLLEQGGLRLLLAALTR"]]}],"s":"MAAAKPTLTDSLSFCLAQLAAAAGEALGGEKDPATNETPLSRALLALRTRHIKAAGGIERFRARGGLRPLLALLRRAAAAGSAPSQAGPGSAPSSAASGASSPAPASGPAPSAVSSSSPTPPVRLRKTLDLALSILADCCTEGACRTEVRRLGGILPLVTILQCMKTDSIQNRTARALGNLAMEPESCGDIHCAGAVPLLVESLTACQDSQCLQSVVRALRNLADSPQHRLALAQQGAVRPLAELLATAPDAALTLALVRALLELSRGCSRACAEQLSLGGGLGPLVSLASHPKRAVREGTILILANLCAQGLIRPALGNAGGVEVLVDELRQRRDPNGASPTSQQPLVRAVCLLCREAINRARLRDAGGLDLLMGLLRDPRASAWHPRIVAALVGFLYDTGALGRLQALGLVPLLAGQLCGEAGEEEEEGREAASWDFPEERTPERAQGGSFRSLRSWLISEGYATGPDDISPDWSPEQCPPEPMEPASPAPTPTSLRAPRTQRTPGRSPAAAIEEPWGREGPALLLLSRFSQAPDPSGALVTGPALYGLLTYVTGAPGPPSPRALRILSRLTCNPACLEAFVRSYGAALLRAWLVLGVAPDDWPAPRARPTLHSRHRELGERLLQNLTVQAESPFGVGALTHLLLSGSPEDRVACALTLPFICRKPSLWRRLLLEQGGLRLLLAALTRPAPHPLFLFFAADSLSCLQDLVSPTVSPAVPQAVPMDLDSPSPCLYEPLLGPAPVPAPDLHFLLDSGLQLPAQRAASATASPFFRALLSGSFAEAQMDLVPLRGLSPGAAWPVLHHLHGCRGCGAALGPVPPPGQPLLGSEAEEALEAAGRFLLPGLEEELEEAVGRIHLGPQGGPESVGEVFRLGRPRLAAHCARWTLGSEQCPRKRGLALVGLVEAAGEEAGPLTEALLAVVMGIELGARVPA"},{"id":"SEQ_03018","a":"Q7Z6P3","g":"RAB44","d":"Ras-related protein Rab-44","L":1021,"m":[{"c":"PP[SR]GAQPGAGAGPQEPTQTPPTM[TA]E[RQ]E[TA]QP[GR]PS[PL]TTA","u":37,"sp":"dispersed","x":"disordered_like","cf":"high","why":"High-conservation 37-residue internal duplication (31/37 identical positions, including an invariant 20-aa GAQPGAGAGPQEPTQTPPTM core and C-terminal TTA anchor) occurring as two dispersed copies within the central Pro/Thr/Gln-rich disordered region.","i":[[537,573,"PPSGAQPGAGAGPQEPTQTPPTMTERETQPGPSPTTA"],[746,782,"PPRGAQPGAGAGPQEPTQTPPTMAEQEAQPRPSLTTA"]]}],"s":"METGQRTSRKVRKLGSNRRRQTREPADGEGAAVAPEPESWSSQAAAELQAFFQDCGAKERGFVTREDLAVAKFSFLGSKEESEMIFDWVDVERKGHLSLEEFSSGLKNIFGSSQSPHRLRRRKPLPSKRVSATTSFPALEEADAEEKEAFLAFMEQLGTGHLLPKQMEIWQLWGQLRQEEPQLAGNLAGFLAKMTSRLQEAQADKEALELTLRKRDSDHHREVQQLYEEMEQQIRQEKQQLQAESDSRGLALTSQMQDVLEAKEREVQRLAEGQRELEAQLSHLRSTHQEAASENQQLQEAKRDLAGRLEEVRGQLQVTRGRLDAARGRVSWQVEEKLSFPGAGEKTPDPQAASPEEAPLPGLFGDNDDWDQLLSNFGSPPHGALQLCWSPPPTPRATSGPQTPRVVRQISISEPQAFLFGQEPSSDPDGAPRTPPGVTFSAKDNKGVDPHEQDIRAEQPVEPHDPDPNQEPGSTPEGRLLWGLSGSLVAPAFKVLIPLEDGPPPPANSPPPQAPAGSSKQIQASDPDDKGPGSWAPPSGAQPGAGAGPQEPTQTPPTMTERETQPGPSPTTALTGVGPAKPPRQRDALQQDLHATGSEPRLGTQRARALTLGPAEPFQGLEFVGPVPTERLEQGQAGPAVQEGLPEGLREAHGQVLGLGELSAFPHQELEEEPRSEEGKQEGRGGQDLSSEQSEQSVEAHGLETAHSELPQQDSLLVSLPSATPQAQVEAEGPTPGKSAPPRGSPPRGAQPGAGAGPQEPTQTPPTMAEQEAQPRPSLTTAHAEEQGPPHSREPRAESRLEDPGMDSREAGLTPSPGDPMAGGGPQANPDYLFHVIFLGDSNVGKTSFLHLLHQNSFATGLTATVGVDFRVKTLLVDNKCFVLQLWDTAGQERYHSMTRQLLRKADGVVLMYDITSQESFAHVRYWLDCLQDAGSDGVVILLLGNKMDCEEERQVSVEAGQQLAQELGVYFGECSAALGHNILEPVVNLARSLRMQEEGLKDSLVKVAPKRPPKRFGCCS"},{"id":"SEQ_03025","a":"Q9NRE2","g":"TSHZ2","d":"Teashirt homolog 2","L":1034,"m":[{"c":"[FL]xCxxCxxx[FYH]x[ST]xxxφxxH[LM](x){2,4}H","u":"23-25","sp":"dispersed","x":"structured_like","cf":"high","why":"Five dispersed 23-25 aa repeats anchored by invariant CxxC and H[LM](x){2,4}H pairs, along with a conserved N-terminal [FL], an internal [FYH]x[ST] signature, and a hydrophobic residue three positions upstream of the first H.","i":[[215,239,"FRCRQCSAAYDTLVELTVHMNETGH"],[275,299,"LKCMFCGDSFDSLQDLSVHMIKTKH"],[380,404,"LKCMECGSSHDTLQQLTTHMMVTGH"],[926,948,"FYCSDCASQFRTPSTYISHLESH"],[994,1017,"FKCKLCCRTFVSKHAVKLHLSKTH"]]}],"s":"MPRRKQQAPKRAAGYAQEEQLKEEEEIKEEEEEEDSGSVAQLQGGNDTGTDEELETGPEQKGCFSYQNSPGSHLSNQDAENESLLSDASDQVSDIKSVCGRDASDKKAHTHVRLPNEAHNCMDKMTAVYANILSDSYWSGLGLGFKLSNSERRNCDTRNGSNKSDFDWHQDALSKSLQQNLPSRSVSKPSLFSSVQLYRQSSKMCGTVFTGASRFRCRQCSAAYDTLVELTVHMNETGHYQDDNRKKDKLRPTSYSKPRKRAFQDMDKEDAQKVLKCMFCGDSFDSLQDLSVHMIKTKHYQKVPLKEPVPTISSKMVTPAKKRVFDVNRPCSPDSTTGSFADSFSSQKNANLQLSSNNRYGYQNGASYTWQFEACKSQILKCMECGSSHDTLQQLTTHMMVTGHFLKVTSSASKKGKQLVLDPLAVEKMQSLSEAPNSDSLAPKPSSNSASDCTASTTELKKESKKERPEETSKDEKVVKSEDYEDPLQKPLDPTIKYQYLREEDLEDGSKGGGDILKSLENTVTTAINKAQNGAPSWSAYPSIHAAYQLSEGTKPPLPMGSQVLQIRPNLTNKLRPIAPKWKVMPLVSMPTHLAPYTQVKKESEDKDEAVKECGKESPHEEASSFSHSEGDSFRKSETPPEAKKTELGPLKEEEKLMKEGSEKEKPQPLEPTSALSNGCALANHAPALPCINPLSALQSVLNNHLGKATEPLRSPSCSSPSSSTISMFHKSNLNVMDKPVLSPASTRSASVSRRYLFENSDQPIDLTKSKSKKAESSQAQSCMSPPQKHALSDIADMVKVLPKATTPKPASSSRVPPMKLEMDVRRFEDVSSEVSTLHKRKGRQSNWNPQHLLILQAQFASSLFQTSEGKYLLSDLGPQERMQISKFTGLSMTTISHWLANVKYQLRKTGGTKFLKNMDKGHPIFYCSDCASQFRTPSTYISHLESHLGFQMKDMTRLSVDQQSKVEQEISRVSSAQRSPETIAAEEDTDSKFKCKLCCRTFVSKHAVKLHLSKTHSKSPEHHSQFVTDVDEE"},{"id":"SEQ_03034","a":"Q8N393","g":"ZNF786","d":"Zinc finger protein 786","L":782,"m":[{"c":"[PH]FxC(x){1,2}Cxxx[FY]xxxxx[LM]xxHxxxHxxxx","u":"27-28","sp":"tandem","x":"structured_like","cf":"high","why":"Fourteen conserved 27-28 aa repeats (13 head-to-tail tandem copies across residues 396-758 plus 1 intact upstream copy at 239-266 separated by degraded relic units) anchored by invariant F, paired cysteines C-x(1,2)-C, central [FY] and [LM] hydrophobics, and an invariant H-x3-H motif.","i":[[239,266,"HFRCGVCGKSFRRKLCLLRHLAAHTGRG"],[396,423,"PFQCAHCTKRFRLRRLLQVHQHAHGGER"],[424,451,"PFSCRKCGKGFAKQCKLTEHIRVHSGEK"],[452,479,"PFRCAKCGRNFRQRGQLLRHQRLHTDEK"],[480,507,"PFQCPECGLSFRLESMLRAHRLRHGGER"],[508,535,"PFSCSECGRGFTHQCKLREHLRVHSGER"],[536,563,"PFQCLKCDKRFRLKGILKAHQHTHSKER"],[564,591,"PFSCGECGKGFTRQSKLTEHLRVHSGER"],[592,619,"PFQCPECNRSFRLKGQLLSHQRLHTGER"],[620,647,"PFQCPECDKRYRVKADMKAHQLLHSGEM"],[648,674,"PFSCECGKGFVKHSKLIEHIRTHTGEK"],[675,702,"PFQCPKCDKSFRLKAQLLSHQGLHTGER"],[703,730,"PFHCPECDKNFRERGHMLRHQRIHRPER"],[731,758,"PFACGDCGKGFIYKSKLAEHIRVHTKSC"]]}],"s":"MAEPPRLPLTFEDVAIYFSEQEWQDLEAWQKELYKHVMRSNYETLVSLDDGLPKPELISWIEHGGEPFRKWRESQKSGNIICSSVDMHFDPGFEEQLFWGSQQAMNSGKTKSHFQLDPESQCSFGSFVSFRPDQGITLGSPQRHDARAPPPLACGPSESTLKEGIPGPRNLDLPGLWDVPAWESTQHPWPVCGESCWENNHLVMHQRGHSKDRTRRAWEKFNKRAETQMPWSSPRVQRHFRCGVCGKSFRRKLCLLRHLAAHTGRGPFRNADGEMCFRHELTHPSHRLPQQGEKPAQCTPCGKRSLPVDSTQARRCQHSREGPASWREGRGASSSVHSGQKPGSRLPQEGNSHQEGDTEALQHGAEGPCSCSECGERSPMSARLASPCRAHTGEKPFQCAHCTKRFRLRRLLQVHQHAHGGERPFSCRKCGKGFAKQCKLTEHIRVHSGEKPFRCAKCGRNFRQRGQLLRHQRLHTDEKPFQCPECGLSFRLESMLRAHRLRHGGERPFSCSECGRGFTHQCKLREHLRVHSGERPFQCLKCDKRFRLKGILKAHQHTHSKERPFSCGECGKGFTRQSKLTEHLRVHSGERPFQCPECNRSFRLKGQLLSHQRLHTGERPFQCPECDKRYRVKADMKAHQLLHSGEMPFSCECGKGFVKHSKLIEHIRTHTGEKPFQCPKCDKSFRLKAQLLSHQGLHTGERPFHCPECDKNFRERGHMLRHQRIHRPERPFACGDCGKGFIYKSKLAEHIRVHTKSCPAPNELDIKKRLSQLFAMIEADWS"},{"id":"SEQ_03038","a":"Q8N6L0","g":"KASH5","d":"Protein KASH5","L":562,"m":[{"c":"[AV]T[AV]DLxxxL","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed 9-residue motifs located in P/E/G-enriched linker and disordered segments outside the central heptad coiled-coil region, featuring strictly invariant T2, D4, L5, and L9 anchors alongside [AV]1 and [AV]3.","i":[[90,98,"ATVDLDTFL"],[158,166,"ATADLLSSL"],[387,395,"ATADLSNPL"],[457,465,"VTADLPVPL"]]}],"s":"MDLPEGPVGGPTAEMYLRERPEEARLGMPVSLEEQILNSTFEACDPQRTGTVAVAQVLAYLEAVTGQGPQDARLQTLANSLDPNGEGPKATVDLDTFLVVMRDWIAACQLHGGLELEEETAFQGALTSRQLPSGCPEAEEPANLESFGGEDPRPELQATADLLSSLEDLELSNRRLVGENAKLQRSMETAEEGSARLGEEILALRKQLHSTQQALQFAKAMDEELEDLKTLARSLEEQNRSLLAQARQAEKEQQHLVAEMETLQEENGKLLAERDGVKKRSQELAMEKDTLKRQLFECEHLICQRDTILSERTRDVESLAQTLEEYRVTTQELRLEISRLEEQLSQTYEGPDELPEGAQLRRVGWTELLPPSLGLEIEAIRQKQEVATADLSNPLCGVWQWEEVIHETSEETEFPSEAPAGGQRNFQGEPAHPEEGRKEPSMWLTRREEEEDAESQVTADLPVPLGAPRPGDIPENPPERPARRELQQALVPVMKKLVPVRRRAWGQLCLPPQRLRVTRHPLIPAPVLGLLLLLLLSVLLLGPSPPPTWPHLQLCYLQPPPV"},{"id":"SEQ_03041","a":"P39687","g":"ANP32A","d":"Acidic leucine-rich nuclear phosphoprotein 32 family member A","L":249,"m":[{"c":"φxxLx[LF](x){1,4}[NC](x){2,7}L(x){6,11}","u":"22-25","sp":"tandem","x":"structured_like","cf":"high","why":"Five contiguous 22-25 aa head-to-tail tandem repeats spanning residues 19-139 in the N-terminal structured region (preceding an unanchored C-terminal D/E-rich low-complexity tail), defined by a conserved φxxLx[LF] core, a turn [NC] anchor, and a downstream L position.","i":[[19,40,"VKELVLDNSRSNEGKLEGLTDE"],[41,65,"FEELEFLSTINVGLTSIANLPKLNK"],[66,89,"LKKLELSDNRVSGGLEVLAEKCPN"],[90,114,"LTHLNLSGNKIKDLSTIEPLKKLEN"],[115,139,"LKSLDLFNCEVTNLNDYRENVFKLL"]]}],"s":"MEMGRRIHLELRNRTPSDVKELVLDNSRSNEGKLEGLTDEFEELEFLSTINVGLTSIANLPKLNKLKKLELSDNRVSGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDLFNCEVTNLNDYRENVFKLLPQLTYLDGYDRDDKEAPDSDAEGYVEGLDDEEEDEDEEEYDEDAQVVEDEEDEDEEEEGEEEDVSGEEEEDEEGYNDGEVDDEEDEEELGEEERGQKRKREPEDEGEDDD"},{"id":"SEQ_03045","a":"Q9ULN7","g":"PNMA8B","d":"Paraneoplastic antigen-like protein 8B","L":635,"m":[{"c":"-φ[LV]A[LI][LV][AT]φ[RTQ]-","u":10,"sp":"dispersed","x":"mixed","cf":"high","why":"Five dispersed 10-residue copies share an invariant central alanine (pos 4), conserved N- and C-terminal acidic caps (pos 1 and 10), and a tightly constrained aliphatic/hydrophobic core (pos 2-3, 5-6, 8) interspersed with polar/acidic linkers and structured segments.","i":[[252,261,"EFLALVTVTD"],[291,300,"DLVALLAVRD"],[331,340,"EFVAIVAYTD"],[450,459,"ELVALLAAQD"],[486,495,"EVLALLAARE"]]}],"s":"MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNEKAQAALVEFVEDVNHAAIPREIPGKDGVWRVLWKDRAQDTRVLRQMRRLLLDDGPTQAAEAGTPGEAPTPPASETQAQDSGEVTGQAGSLLGAARNPRRGRRGRRNRTRRNRLTQKGKKRSRGGRPSAPARSEAEDSSDESLGIVIEEIDQGDLSGEEDQSALYATLQAAARELVRQWAPCNSEGEEDGPREFLALVTVTDKSKKEEAEKEPAGAESIRLNTKEDKNGVPDLVALLAVRDTPDEEPVDSDTSESDSQESGDQETEELDNPEFVAIVAYTDPSDPWAREEMLKIASVIESLGWSDEKDKRDPLRQVLSVMSKDTNGTRVKVEEAGREVDAVVLRKAGDDGDLRECISTLAQPDLPPQAKKAGRGLFGGWSEHREDEGGLLELVALLAAQDMAEVMKEEKENAWEGGKYKYPKGKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEASEPEDRASRKPRAKRARTAPRGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSRKKKGSAGAGAHARAGEAKGQAPTGSKAARGKKARRGRRLPPKCR"},{"id":"SEQ_03046","a":"Q9HBL0","g":"TNS1","d":"Tensin-1","L":1839,"m":[{"c":"P[GS]SP[SC]Lx[RH]H","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five clustered copies of a 9-residue motif in the C-terminal part of the long central disordered region (residues 1311-1424), anchored by invariant P1, S3, P4, L6, and H9 positions alongside tightly constrained [GS]2, [SC]5, and [RH]8 choices separated by variable 8-25 aa linkers.","i":[[1311,1319,"PSSPSLSHH"],[1345,1353,"PGSPSLCRH"],[1371,1379,"PGSPSLGRH"],[1399,1407,"PGSPSLGRH"],[1416,1424,"PGSPCLDRH"]]}],"s":"MTWICLSCMLWPEDLEAPKTHRFKVKTFKKVKPCGICRQVITQEGCTCKVCSFSCHRKCQAKVAAPCVPPSNHELVPITTENAPKNVVDKGEGASRGGNTRKSLEDNGSTRVTPSVQPHLQPIRNMSVSRTMEDSCELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSERRPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMNNKPLFLHHVIMHGIPNFESKGGCRPFLRIYQAMQPVYTSGIYNIPGDSQTSVCITIEPGLLLKGDILLKCYHKKFRSPARDVIFRVQFHTCAIHDLGVVFGKEDLDDAFKDDRFPEYGKVEFVFSYGPEKIQGMEHLENGPSVSVDYNTSDPLIRWDSYDNFSGHRDDGMEEVVGHTQGPLDGSLYAKVKKKDSLHGSTGAVNATRPTLSATPNHVEHTLSVSSDSGNSTASTKTDKTDEPVPGASSATAALSPQEKRELDRLLSGFGLEREKQGAMYHTQHLRSRPAGGSAVPSSGRHVVPAQVHVNGGALASERETDILDDELPNQDGHSAGSMGTLSSLDGVTNTSEGGYPEALSPLTNGLDKSYPMEPMVNGGGYPYESASRAGPAHAGHTAPMRPSYSAQEGLAGYQREGPHPAWPQPVTTSHYAHDPSGMFRSQSFSEAEPQLPPAPVRGGSSREAVQRGLNSWQQQQQQQQQPRPPPRQQERAHLESLVASRPSPQPLAETPIPSLPEFPRAASQQEIEQSIETLNMLMLDLEPASAAAPLHKSQSVPGAWPGASPLSSQPLSGSSRQSHPLTQSRSGYIPSGHSLGTPEPAPRASLESVPPGRSYSPYDYQPCLAGPNQDFHSKSPASSSLPAFLPTTHSPPGPQQPPASLPGLTAQPLLSPKEATSDPSRTPEEEPLNLEGLVAHRVAGVQAREKQPAEPPAPLRRRAASDGQYENQSPEATSPRSPGVRSPVQCVSPELALTIALNPGGRPKEPHLHSYKEAFEEMEGTSPSSPPPSGVRSPPGLAKTPLSALGLKPHNPADILLHPTGEPRSYVESVARTAVAGPRAQDSEPKSFSAPATQAYGHEIPLRNGTLGGSFVSPSPLSTSSPILSADSTSVGSFPSGESSDQGPRTPTQPLLESGFRSGSLGQPSPSAQRNYQSSSPLPTVGSSYSSPDYSLQHFSSSPESQARAQFSVAGVHTVPGSPQARHRTVGTNTPPSPGFGWRAINPSMAAPSSPSLSHHQMMGPPGTGFHGSTVSSPQSSAATTPGSPSLCRHPAGVYQVSGLHNKVATTPGSPSLGRHPGAHQGNLASGLHSNAIASPGSPSLGRHLGGSGSVVPGSPCLDRHVAYGGYSTPEDRRPTLSRQSSASGYQAPSTPSFPVSPAYYPGLSSPATSPSPDSAAFRQGSPTPALPEKRRMSVGDRAGSLPNYATINGKVSSPVASGMSSPSGGSTVSFSHTLPDFSKYSMPDNSPETRAKVKFVQDTSKYWYKPEISREQAIALLKDQEPGAFIIRDSHSFRGAYGLAMKVSSPPPTIMQQNKKGDMTHELVRHFLIETGPRGVKLKGCPNEPNFGSLSALVYQHSIIPLALPCKLVIPNRDPTDESKDSSGPANSTADLLKQGAACNVLFVNSVDMESLTGPQAISKATSETLAADPTPAATIVHFKVSAQGITLTDNQRKLFFRRHYPLNTVTFCDLDPQERKWMKTEGGAPAKLFGFVARKQGSTTDNACHLFAELDPNQPASAIVNFVSKVMLNAGQKR"},{"id":"SEQ_03060","a":"O00257","g":"CBX4","d":"E3 SUMO-protein ligase CBX4","L":560,"m":[{"c":"Y[EQ]LNSKKHHxYQPxxK","u":16,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Two highly conserved 16-aa copies separated by a 16-aa GK/PPPP-rich linker in a disordered region, sharing 12/16 identical anchor positions (Y, LNSKKHH, YQP, and C-terminal K) and an isosteric [EQ] substitution at position 2.","i":[[120,135,"YELNSKKHHQYQPHSK"],[152,167,"YQLNSKKHHPYQPDPK"]]}],"s":"MELPAVGEHVFAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIAFQNRERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSSTDNRAKLDLGAQGKGQGHQYELNSKKHHQYQPHSKERAGKPPPPGKSGKYYYQLNSKKHHPYQPDPKMYDLQYQGGHKEAPSPTCPDLGAKSHPPDKWAQGAGAKGYLGAVKPLAGAAGAPGKGSEKGPPNGMMPAPKEAVTGNGIGGKMKIVKNKNKNGRIVIVMSKYMENGMQAVKIKSGEVAEGEARSPSHKKRAADERHPPADRTFKKAAGAEEKKVEAPPKRREEEVSGVSDPQPQDAGSRKLSPTKEAFGEQPLQLTTKPDLLAWDPARNTHPPSHHPHPHPHHHHHHHHHHHHAVGLNLSHVRKRCLSETHGEREPCKKRLTARSISTPTCLGGSPAAERPADLPPAAALPQPEVILLDSDLDEPIDLRCVKTRSEAGEPPSSLQVKPETPASAAVAVAAAAAPTTTAEKPPAEAQDEPAESLSEFKPFFGNIIITDVTANCLTVTFKEYVTV"},{"id":"SEQ_03073","a":"Q5JT82","g":"KLF17","d":"Krueppel-like factor 17","L":389,"m":[{"c":"RPYxC(x){2,4}C[GS]xxΩx+[RS][SD][HE]LxxH[QM]+xH[TR]","u":"26-28","sp":"tandem","x":"structured_like","cf":"high","why":"Three tandem 26-28 aa C2H2-like repeats separated by 2-aa linkers (GE, RY), strongly anchored by an N-terminal RPY motif, a C-(x){2,4}-C pair, conserved aromatic/leucine core positions, and a C-terminal H-[QM]-+-x-H-[TR] signature.","i":[[281,308,"RPYCCNYENCGKAYTKRSHLVSHQRKHT"],[311,338,"RPYSCNWESCSWSFFRSDELRRHMRVHT"],[341,366,"RPYKCDQCSREFMRSDHLKQHQKTHR"]]}],"s":"MYGRPQAEMEQEAGELSRWQAAHQAAQDNENSAPILNMSSSSGSSGVHTSWNQGLPSIQHFPHSAEMLGSPLVSVEAPGQNVNEGGPQFSMPLPERGMSYCPQATLTPSRMIYCQRMSPPQQEMTIFSGPQLMPVGEPNIPRVARPFGGNLRMPPNGLPVSASTGIPIMSHTGNPPVPYPGLSTVPSDETLLGPTVPSTEAQAVLPSMAQMLPPQDAHDLGMPPAESQSLLVLGSQDSLVSQPDSQEGPFLPEQPGPAPQTVEKNSRPQEGTGRRGSSEARPYCCNYENCGKAYTKRSHLVSHQRKHTGERPYSCNWESCSWSFFRSDELRRHMRVHTRYRPYKCDQCSREFMRSDHLKQHQKTHRPGPSDPQANNNNGEQDSPPAAGP"},{"id":"SEQ_03074","a":"P0DX52","g":"GOLGA8F","d":"Golgin subfamily A member 8F","L":636,"m":[{"c":"Q[KEQ]ERL[RQP][EQ]","u":7,"sp":"tandem","x":"mixed","cf":"high","why":"Four contiguous head-to-tail 7-aa sequence repeats sharing four invariant anchor positions (Q at pos 1, ERL at pos 3-5) and constrained polar/charged flanking positions (including a helix-disrupting proline in copy 3), distinct from the surrounding generic coiled-coil heptads.","i":[[340,346,"QKERLRE"],[347,353,"QEERLQE"],[354,360,"QQERLPE"],[361,367,"QEERLQQ"]]}],"s":"MAEETRQSKLAAAKRKLKEYWQRNSPGVPAGAKRNRKTNGSIHETATSGGCHSPGDSATGIHGESPTSSATLKDLESPCQELAVVPDSRSVKVSQLKNTIKSLKQQNKQVEHQLEEEKKANNEKQKAERELEVQIQRLNIQKGKLNTDLYHTKRSLRYFEEESKDLAVRLQHSLQRKGELERALSAVTATQKKKAERQFSSRSKARMEWKLEQSMREQALLKAQLTQLKESLKEVQLERDEYAEHLKGERARWQQRMRKMSQEVCSLKKEKKHDKYRVEKLERSLSKLKHQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQAQVEYNQRISLLNEGQKERLREQEERLQEQQERLPEQEERLQQLAEPQNSFKELNNENKSVLQLEQQVKELQEKLGKERLEAASQQKQQLTAQLSLMALPGEGDGGGHLDSEGEEAPRPIPSIPQDLESREAMSGFMDHLEEKADLSELVEKEELGFFQYYRERCHQKVYHPITKPGGSAKDAAPGGGHHQAGPGQGGDEGEAAGAAGDGVAAGGDYKGHSKFLVTAQNPAHEPSPGAPAPQELGAAHKHGDLCEVSLTDSVEPVQGEAREGSPHDNPTAQPIVQDHQEHPGLGSNCCVPFFCWAWLPRRRR"},{"id":"SEQ_03091","a":"P0DJD4","g":"RBMY1C","d":"RNA-binding motif protein, Y chromosome, family 1 member C","L":496,"m":[{"c":"N[HR][PR]S[SC][RQ]ETR-YAPP[SH]R[GD][HY][AG]YRD[YN]GHS[RSN][RW][DH]E[HS][SY]SRGY[RS]","u":37,"sp":"tandem","x":"disordered_like","cf":"high","why":"Four head-to-tail tandem 37-aa repeats in a polar/aromatic/charged disordered region, strongly anchored by invariant N, ETR-YAPP, R, YRD, GHS, E, and SRGY motifs across all copies.","i":[[221,257,"NHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYR"],[258,294,"NHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYR"],[295,331,"NRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYR"],[332,368,"NHPSSRETRDYAPPHRDYAYRDYGHSSWDEHSSRGYS"]]}],"s":"MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRTSKSRGFAFITFENPADAKNAAKDMNGKSLHGKAIKVEQAQKPSFQSGGRRRPPASSRNRSPSGSLRSARGSRGGTRGWLPSHEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVCRKDQRNPPSLGRVLPDPREACGSSSYVASIVDGGESRSEKGDSSRY"},{"id":"SEQ_03124","a":"Q8IVA1","g":"PCP2","d":"Purkinje cell protein 2 homolog","L":136,"m":[{"c":"P-x-xφφxψLxxxQGxRM-xQRx[ST]ψoxxPG","u":30,"sp":"dispersed","x":"mixed","cf":"high","why":"Gapless 30-residue internal duplication sharing 10 identical anchors (N-terminal P, L, QGxRM, QR, and C-terminal PG) plus conserved acidic and hydrophobic positions across both copies separated by a 10-aa linker.","i":[[21,50,"PDQEGFFNLLSHVQGDRMEGQRCSLQAGPG"],[61,90,"PEMDSLMDMLASTQGRRMDDQRVTVSSLPG"]]}],"s":"MMDQEEKTEEGSGPCAEAGSPDQEGFFNLLSHVQGDRMEGQRCSLQAGPGQTTKSQSDPTPEMDSLMDMLASTQGRRMDDQRVTVSSLPGFQPVGSKDGAQKRAGTLSPQPLLTPQDPTALGFRRNSSPQPPTQAP"},{"id":"SEQ_03130","a":"A0FGR8","g":"ESYT2","d":"Extended synaptotagmin-2","L":921,"m":[{"c":"xL[RI]ψxφxx[AC][QR][DN]L(x){7,14}S[DN]P[YN]xxψx(x){16,21}P[KV]Ω[NED][EQ]xΩxφxψx(x){19,26}LGxψxψxL","u":"84-94","sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed ~84-94 aa structured domain repeats anchored by four conserved beta/loop blocks: xL[RI]ψxφxx[AC][QR][DN]L, S[DN]P[YN]xxψx, P[KV]Ω[NED][EQ]xΩxφxψx, and C-terminal LGxψxψxL.","i":[[386,476,"VLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDL"],[537,620,"LLILYLDSARNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPL"],[802,895,"KLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVAL"]]}],"s":"MTANRDAALSSHRHPGCAQRPRTPTFASSSQRRSAFGFDDGNFPGLGERSHAPGSRLGARRRAKTARGLRGHRQRGAGAGLSRPGSARAPSPPRPGGPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT"},{"id":"SEQ_03140","a":"O00203","g":"AP3B1","d":"AP-3 complex subunit beta-1","L":1094,"m":[{"c":"TP[AV]φxP","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three non-overlapping 6-aa motifs in the disordered C-terminal linker region defined by invariant N-terminal TP and C-terminal P anchors flanking conserved hydrophobic positions ([AV] and φ); two copies occur head-to-tail and the third 22 aa downstream.","i":[[829,834,"TPVALP"],[835,840,"TPALSP"],[862,867,"TPAFVP"]]}],"s":"MSSNSFPYNEQSGGGEATELGQEATSTISPSGAFGLFSSDLKKNEDLKQMLESNKDSAKLDAMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEASADLSPYVRKNAAHAIQKLYSLDPEQKEMLIEVIEKLLKDKSTLVAGSVVMAFEEVCPDRIDLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVSPWKEGDELEDNGKNFYESDDDQKEKTDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVKSQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIKHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVPNVKSGALSKYAKKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWPEVAPDPSVRNVEVIELAKEWTPAGKAKQENSAKKFYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQDSESGRESGLENKRTAKRNSKAKGKSDSEDGEKENEKSKTSDSSNDESSSIEDSSSDSESESEPESESESRRVTKEKEKKTKQDRTPLTKDVSLLDLDDFNPVSTPVALPTPALSPSLMADLEGLHLSTSSSVISVSTPAFVPTKTHVLLHRMSGKGLAAHYFFPRQPCIFGDKMVSIQITLNNTTDRKIENIHIGEKKLPIGMKMHVFNPIDSLEPEGSITVSMGIDFCDSTQTASFQLCTKDDCFNVNIQPPVGELLLPVAMSEKDFKKEQGVLTGMNETSAVIIAAPQNFTPSVIFQKVVNVANVGAVPSGQDNIHRFAAKTVHSGSLMLVTVELKEGSTAQLIINTEKTVIGSVLLRELKPVLSQG"},{"id":"SEQ_03149","a":"Q96E39","g":"RBMXL1","d":"RNA binding motif protein, X-linked-like-1","L":390,"m":[{"c":"[SG]RD[SDG]Y[SGP][SG]","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five copies in the C-terminal R/S/G/Y-rich disordered region (including a head-to-tail tandem pair SRDGYGG-SRDSYSS) share invariant R2, D3, and Y5 anchors flanked by small/polar [SG]/[SDG]/[SGP] positions and followed by basic R/SR/SSR motifs.","i":[[186,192,"GRDSYGG"],[251,257,"SRDDYPS"],[316,322,"SRDGYGG"],[323,329,"SRDSYSS"],[359,365,"SRDSYSS"]]},{"c":"[STK]RGPP[PRS][GRS]xG","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four non-overlapping dispersed 9-mer copies across the central disordered linker share an invariant RGPP core and C-terminal G9 anchor with tightly constrained [STK]1, [PRS]6, and [GRS]7 positions.","i":[[102,110,"SRGPPRGFG"],[119,127,"TRGPPSRGG"],[150,158,"KRGPPPRSG"],[297,305,"TRGPPPSYG"]]}],"s":"MVEADRPGKLFIGGLNTETNEKALETVFGKYGRIVEVLLIKDRETNKSRGFAFVTFESPADAKDAARDMNGKSLDGKAIKVEQATKPSFERGRHGPPPPPRSRGPPRGFGAGRGGSGGTRGPPSRGGHMDDGGYSMNFNMSSSRGPLPVKRGPPPRSGGPSPKRSAPSGLVRSSSGMGGRAPLSRGRDSYGGPPRREPLPSRRDVYLSPRDDGYSTKDSYSSRDYPSSRDTRDYAPPPRDYTYRDYGHSSSRDDYPSRGYGDRDGYGRDRDYSDHPSGGSYRDSYESYGNSRSAPLTRGPPPSYGGSSRYDDYSSSRDGYGGSRDSYSSSRSDLYSSCDRVGRQERGLPPSVERGYPSSRDSYSSSSRGAPRGAGPGGSRSDRGGGRSRY"},{"id":"SEQ_03152","a":"Q8TAD8","g":"SNIP1","d":"Smad nuclear-interacting protein 1","L":396,"m":[{"c":"VK[QS]ER","u":5,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed occurrences in the hydrophobic-depleted N-terminal R/E/H/S-rich disordered region share invariant V1, K2, E4, and R5 anchors with a polar [QS]3 choice (with copies 2 and 3 extending left as VxVKQER and copies 1 and 3 extending right with E).","i":[[4,8,"VKSER"],[29,33,"VKQER"],[107,111,"VKQER"]]}],"s":"MKAVKSERERGSRRRHRDGDVVLPAGVVVKQERLSPEVAPPAHRRPDHSGGSPSPPTSEPARSGHRGNRARGVSRSPPKKKNKASGRRSKSPRSKRNRSPHHSTVKVKQEREDHPRRGREDRQHREPSEQEHRRARNSDRDRHRGHSHQRRTSNERPGSGQGQGRDRDTQNLQAQEEEREFYNARRREHRQRNDVGGGGSESQELVPRPGGNNKEKEVPAKEKPSFELSGALLEDTNTFRGVVIKYSEPPEARIPKKRWRLYPFKNDEVLPVMYIHRQSAYLLGRHRRIADIPIDHPSCSKQHAVFQYRLVEYTRADGTVGRRVKPYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVLLHESSDTSEIDRKDDEDEEEEEEVSDS"},{"id":"SEQ_03157","a":"A1L4H1","g":"SSC5D","d":"Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D","L":1573,"m":[{"c":"[RQ]ψRL[AV]xGP[HSN][GKR]C[AS]GRLEVWH[GDA][GQ]RWG[TS]VCDDxWDψRD[AS][AT]V[AV]C[RW][EQ]LGCG(x){10,11}ΩG[EPW]G[AST]GPψφψ[DS]-ψ[AGR]CxGxEx[QAS]L[GRS][DLF]C[PH]xx[PGA]W[GK]x[HS][NDI]CxHxED[AV]Gφ[VT]C[TAD]G","u":"103-104","sp":"dispersed","x":"structured_like","cf":"high","why":"Five strongly conserved ~103-104 aa cysteine-rich globular repeats anchored by 8 invariant cysteines, invariant GRLEVWH, RWGxVCDD, WDψRD, LGCG, GxGP, and EDxGxxCxG motifs separated by variable disordered linkers.","i":[[19,121,"RLRLADGPHGCAGRLEVWHGGRWGTVCDDGWDLRDAAVACRQLGCGGALAAPGGAFFGEGAGPVWLSELACRGNEGQLGLCHHRGWKAHICSHEEDAGVVCAG"],[197,299,"RLRLVSGPHRCAGRLEVWHGGRWGTVCDDGWDLRDAAVACRELGCGGALAAPGGARFGPGAGPVWMDDVGCGGGEQALRDCPRSPWGRSNCDHSEDAGLVCTG"],[303,405,"RLRLADGPHGCAGRLEVWHGGRWGSVCDDAWDLRDAAVACRELGCGGALAAPGGAFFGEGSGPIILDDLRCRGNETALRFCPARPWGQHDCHHREDAGAVCDG"],[466,569,"QLRLVAGPSKCSGRLEVWHDQRWGTVCDDSWDMRDSAVVCRELGCGGPQQPDPAAGRFGWGAGPIWLDDVGCVGTEASLSDCPAAPWGKHNCAHNEDVGVTCTG"],[771,873,"RVRLADGPNRCAGRLEVWHAGRWGTVCDDNWDLRDATVACWELGCGKVRPRVGKTHYGPGTGPIWLDDMGCKGSEASLSDCPSGAWGKHNCDHEEDVGLTCTG"]]},{"c":"TTITHSTMIPDPTTTPQPF","u":19,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three 100%-identical 19-aa copies within the Pro/Thr/Ser-rich disordered region (two head-to-tail copies and a third separated by a 22-aa linker), anchored by conserved H, M, I, D, Q, F, and P positions.","i":[[1188,1206,"TTITHSTMIPDPTTTPQPF"],[1207,1225,"TTITHSTMIPDPTTTPQPF"],[1248,1266,"TTITHSTMIPDPTTTPQPF"]]},{"c":"[PL]PWTWD[PT][PT]SxxxLA[KE]GT[PT]TAGx[PL]G[HP]TL[PG]φxTTR[RS]PGS[SP](x){7,8}DTGS","u":"49-50","sp":"dispersed","x":"mixed","cf":"high","why":"Two closely spaced 49-50 aa internal duplications (~50% sequence identity) sharing conserved PWTWD, LA[KE]GT[PT]TAG, TL, TTR[RS]PGS, and C-terminal DTGS anchors.","i":[[881,930,"PPWTWDPTSREDLAKGTTTAGVPGHTLPWRTTRRPGSSSPAIRRLPDTGS"],[936,984,"LPWTWDTPSGRGLAEGTPTAGKLGPTLGAGTTRSPGSPPTLRVHGDTGS"]]},{"c":"PT[TM][TM]P[HDY]","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Thirteen non-overlapping 6-aa copies (including a 9-copy head-to-tail tandem array) in the Pro/Thr-rich disordered region, anchored by fixed prolines at positions 1 and 5 and a conserved C-terminal His/Asp/Tyr residue.","i":[[1151,1156,"PTTTPD"],[1181,1186,"PTTTPH"],[1230,1235,"PTTTPH"],[1241,1246,"PTTTPH"],[1271,1276,"PTTMPH"],[1277,1282,"PTTTPH"],[1283,1288,"PTTTPH"],[1289,1294,"PTTTPH"],[1295,1300,"PTTTPH"],[1301,1306,"PTMTPD"],[1307,1312,"PTTTPY"],[1313,1318,"PTTTPD"],[1319,1324,"PTTTPH"]]}],"s":"MRVLACLLAALVGIQAVERLRLADGPHGCAGRLEVWHGGRWGTVCDDGWDLRDAAVACRQLGCGGALAAPGGAFFGEGAGPVWLSELACRGNEGQLGLCHHRGWKAHICSHEEDAGVVCAGQRVANSRDDSTSPLDGAPWPGLLLELSPSTEEPLVTHAPRPAGNPQNASRKKSPRPKQAKSTRAPLLTTGAPRQERLRLVSGPHRCAGRLEVWHGGRWGTVCDDGWDLRDAAVACRELGCGGALAAPGGARFGPGAGPVWMDDVGCGGGEQALRDCPRSPWGRSNCDHSEDAGLVCTGPAPRLRLADGPHGCAGRLEVWHGGRWGSVCDDAWDLRDAAVACRELGCGGALAAPGGAFFGEGSGPIILDDLRCRGNETALRFCPARPWGQHDCHHREDAGAVCDGMPLGYVPPTAPTDSNNSTPREAASRPPSTMTSQAPGTAGVSPPPASPTVLWEPGPEAGSPQLRLVAGPSKCSGRLEVWHDQRWGTVCDDSWDMRDSAVVCRELGCGGPQQPDPAAGRFGWGAGPIWLDDVGCVGTEASLSDCPAAPWGKHNCAHNEDVGVTCTGPPGLDSISDPFSWSWIPGLGRDRDAWLPGELATKPSASVTASVLEKTTTKAPGKMPKSTKKWVTKNAKRPTTQPPVMPTTKHSRAQSPPDLTSQTTAALTTEASRRPTSEFTRRPTTEAPQRWTSHTTATLTPQAPRERTTKTMAMLTTQGPQEMTSESTIKSIPQASLEPSAEIPEGSPESPKDPAPSPSVSTTGESGLFRVRLADGPNRCAGRLEVWHAGRWGTVCDDNWDLRDATVACWELGCGKVRPRVGKTHYGPGTGPIWLDDMGCKGSEASLSDCPSGAWGKHNCDHEEDVGLTCTGYTDYDDYPPWTWDPTSREDLAKGTTTAGVPGHTLPWRTTRRPGSSSPAIRRLPDTGSKDGYKLPWTWDTPSGRGLAEGTPTAGKLGPTLGAGTTRSPGSPPTLRVHGDTGSPRKPWPERRPPRPAATRTAPPTPSPGPSASPGPPGPALTSDSSRELTPHSALTSEATSDAPDTSPPTPDPASRTNPDLILTSPDFALSTPDSSVVPALTPEPSPTPLPTLPKELTSDPSTPSEVTSLSPTSEQVPESDTTPDLDTTPYSSTVSEYSRSPDPSPSPHPTTTPDPTMAPDPITTLNPTVTPHFPTTPHPTTTPHPTTITHSTMIPDPTTTPQPFTTITHSTMIPDPTTTPQPFTTMQPTTTPHSTTPHPTTTPHPTTITHSTMIPDPTTTPQPFTTMQPTTMPHPTTTPHPTTTPHPTTTPHPTTTPHPTMTPDPTTTPYPTTTPDPTTTPHPTTPDPSSTPVITTVSLPTSLGTELSSPTLAPTVKPSLHPQLTFTAPAPHTSTSQIPTLEPSPALESSPSRSSTATSMDPLSTEDFKPPRSQSPNLTPPPTHTPHSASDLTVSPDPLLSPTAHPLDHPPLDPLTLGPTPGQSPGPHGPCVAPTPPVRVMACEPPALVELVAAVRDVGGQLQRLTQVVEQERQERQALLLGLTQLVEAARGLGQLGEAVKRLAEMAWTTSMPAPTTTTPEEEERPLRGDV"},{"id":"SEQ_03168","a":"Q9H808","g":"TLE6","d":"Transducin-like enhancer protein 6","L":572,"m":[{"c":"xxxxxxxxxxx(x){0,1}xxφxx[GFV](x){3,6}xxx[WY]xx","u":"27-29","sp":"periodic","x":"structured_like","cf":"high","why":"Seven periodic 27-29 aa beta-propeller-like repeats spanning the C-terminal structured domain (residues 288-570), anchored by a conserved hydrophobic strand core (φ), a G-enriched 4-7 aa loop ([GFV]), and an invariant C-terminal [WY] aromatic anchor.","i":[[288,314,"LVLATAISSFTRHVFTCGRRGIKVWSL"],[336,364,"FLRTCLLSSNSRSLLTGGYNLASVSVWDL"],[382,408,"CQALDANLDANLAFASFTSGVVRIWDL"],[421,448,"PDGVKSIVVKGYNIWTGGPDACLRCWDQ"],[461,487,"SQIMSLSHSPQEDWVLLGMANGQQWLQ"],[502,530,"SVILSVKFSPFGQWWASVGMDDFLGVYSM"],[544,570,"PVTCCDVSSNNRLVVTGSGEHASVYQI"]]}],"s":"MTSRDQPRPKGPPKSTSPCPGISNSESSPTLNYQGILNRLKQFPRFSPHFAAELESIYYSLHKIQQDVAEHHKQIGNVLQIVESCSQLQGFQSEEVSPAEPASPGTPQQVKDKTLQESSFEDIMATRSSDWLRRPLGEDNQPETQLFWDKEPWFWHDTLTEQLWRIFAGVHDEKAKPRDRQQAPGLGQESKAPGSCDPGTDPCPEDASTPRPPEASSSPPEGSQDRNTSWGVVQEPPGRASRFLQSISWDPEDFEDAWKRPDALPGQSKRLAVPCKLEKMRILAHGELVLATAISSFTRHVFTCGRRGIKVWSLTGQVAEDRFPESHLPIQTPGAFLRTCLLSSNSRSLLTGGYNLASVSVWDLAAPSLHVKEQLPCAGLNCQALDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVKGYNIWTGGPDACLRCWDQRTIMKPLEYQFKSQIMSLSHSPQEDWVLLGMANGQQWLQSTSGSQRHMVGQKDSVILSVKFSPFGQWWASVGMDDFLGVYSMPAGTKVFEVPEMSPVTCCDVSSNNRLVVTGSGEHASVYQITY"},{"id":"SEQ_03181","a":"Q9NWQ8","g":"PAG1","d":"Phosphoprotein associated with glycosphingolipid-enriched microdomains 1","L":432,"m":[{"c":"xxxYxx[VLI]","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Nine dispersed copies of a short tyrosine-aliphatic motif (xxxYxx[VLI], frequently enriched for acidic [ED] at -3 and E/A at +1) distributed across the long disordered C-terminal tail (residues 101-422).","i":[[102,108,"MQHYEEV"],[160,166,"EGPYEVL"],[178,184,"DCLYETV"],[224,230,"FAEYASV"],[314,320,"SAMYSSV"],[338,344,"ESTYTSI"],[356,362,"NDLYATV"],[384,390,"EPDYEAI"],[414,420,"ENDYESI"]]}],"s":"MGPAGSLLGSGQMQITLWGSLAAVAIFFVITFLIFLCSSCDREKKPRQHSGDHENLMNVPSDKEMFSRSVTSLATDAPASSEQNGALTNGDILSEDSTLTCMQHYEEVQTSASDLLDSQDSTGKPKCHQSRELPRIPPESAVDTMLTARSVDGDQGLGMEGPYEVLKDSSSQENMVEDCLYETVKEIKEVAAAAHLEKGHSGKAKSTSASKELPGPQTEGKAEFAEYASVDRNKKCRQSVNVESILGNSCDPEEEAPPPVPVKLLDENENLQEKEGGEAEESATDTTSETNKRFSSLSYKSREEDPTLTEEEISAMYSSVNKPGQLVNKSGQSLTVPESTYTSIQGDPQRSPSSCNDLYATVKDFEKTPNSTLPPAGRPSEEPEPDYEAIQTLNREEEKATLGTNGHHGLVPKENDYESISDLQQGRDITRL"},{"id":"SEQ_03186","a":"Q562E7","g":"WDR81","d":"WD repeat-containing protein 81","L":1941,"m":[{"c":"(x){12,19}xxxxxxxxx[AGL]xψ(x){2,5}xφ[LVT]x[GSA](x){1,4}[DSN]xxψx[LVF][WLV]","u":"41-47","sp":"tandem","x":"structured_like","cf":"high","why":"Seven contiguous head-to-tail 41-47 aa beta-propeller (WD40-like) repeats spanning C-terminal residues 1631-1940. Each unit preserves hydrophobic beta-strand cores (xφ[LVT]x and xxψx[LVF][WLV]), an intervening [GSA](x){1,4}[DSN] turn (including canonical SxD/GxD motifs), and short variable inter-strand loops.","i":[[1631,1675,"DAHFHFHQIRLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLW"],[1676,1722,"PLYNYGDGTSETAPRLVYTQHRKSVFFVGQLEAPQHVVSCDGAVHVW"],[1723,1767,"DPFTGKTLRTVEPLDSRVPLTAVAVMPAPHTSITMASSDSTLRFV"],[1768,1813,"DCRKPGLQHEFRLGGGLNPGLVRALAISPSGRSVVAGFSSGFMVLL"],[1814,1854,"DTRTGLVLRGWPAHEGDILQIKAVEGSVLVSSSSDHSLTVW"],[1855,1897,"KELEQKPTHHYKSASDPIHTFDLYGSEVVTGTVSNKIGVCSLL"],[1898,1940,"EPPSQATTKLSSENFRGTLTSLALLPTKRHLLLGSDNGVIRLL"]]}],"s":"MAQGSGGREGALRTPAGGWHSPPSPDMQELLRSVERDLSIDPRQLAPAPGGTHVVALVPARWLASLRDRRLPLGPCPRAEGLGEAEVRTLLQRSVQRLPAGWTRVEVHGLRKRRLSYPLGGGLPFEDGSCGPETLTRFMQEVAAQNYRNLWRHAYHTYGQPYSHSPAPSAVPALDSVRQALQRVYGCSFLPVGETTQCPSYAREGPCPPRGSPACPSLLRAEALLESPEMLYVVHPYVQFSLHDVVTFSPAKLTNSQAKVLFILFRVLRAMDACHRQGLACGALSLYHIAVDEKLCSELRLDLSAYERPEEDENEEAPVARDEAGIVSQEEQGGQPGQPTGQEELRSLVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVVDFTTPHGRFRDLRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPPHVPHHISDVLSDITYYVYKARRTPRSVLCGHVRAQWEPHEYPASMERMQNWTPDECIPEFYTDPSIFRSIHPDMPDLDVPAWCSSSQEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEAVKEKNVCLHLVDAHTHLASYGVVQLFDQPHPQRLAGAPALAPEPPLIPKLLVQTIQETTGREDFTENPGQLPNGVGRPVLEATPCEASWTRDRPVAGEDDLEQATEALDSISLAGKAGDQLGSSSQASPGLLSFSVASASRPGRRNKAAGADPGEGEEGRILLPEGFNPMQALEELEKTGNFLAKGLGGLLEVPEQPRVQPAVPLQCLLHRDMQALGVLLAEMVFATRVRTLQPDAPLWVRFQAVRGLCTRHPKEVPVSLQPVLDTLLQMSGPEVPMGAERGKLDQLFEYRPVSQGLPPPCPSQLLSPFSSVVPFPPYFPALHRFILLYQARRVEDEAQGRELVFALWQQLGAVLKDITPEGLEILLPFVLSLMSEEHTAVYTAWYLFEPVAKALGPKNANKYLLKPLIGAYESPCQLHGRFYLYTDCFVAQLMVRLGLQAFLTHLLPHVLQVLAGAEASQEESKDLAGAAEEEESGLPGAGPGSCAFGEEIPMDGEPPASSGLGLPDYTSGVSFHDQADLPETEDFQAGLYVTESPQPQEAEAVSLGRLSDKSSTSETSLGEERAPDEGGAPVDKSSLRSGDSSQDLKQSEGSEEEEEEEDSCVVLEEEEGEQEEVTGASELTLSDTVLSMETVVAGGSGGDGEEEEEALPEQSEGKEQKILLDTACKMVRWLSAKLGPTVASRHVARNLLRLLTSCYVGPTRQQFTVSSGESPPLSAGNIYQKRPVLGDIVSGPVLSCLLHIARLYGEPVLTYQYLPYISYLVAPGSASGPSRLNSRKEAGLLAAVTLTQKIIVYLSDTTLMDILPRISHEVLLPVLSFLTSLVTGFPSGAQARTILCVKTISLIALICLRIGQEMVQQHLSEPVATFFQVFSQLHELRQQDLKLDPAGRGEGQLPQVVFSDGQQRPVDPALLDELQKVFTLEMAYTIYVPFSCLLGDIIRKIIPNHELVGELAALYLESISPSSRNPASVEPTMPGTGPEWDPHGGGCPQDDGHSGTFGSVLVGNRIQIPNDSRPENPGPLGPISGVGGGGLGSGSDDNALKQELPRSVHGLSGNWLAYWQYEIGVSQQDAHFHFHQIRLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLYNYGDGTSETAPRLVYTQHRKSVFFVGQLEAPQHVVSCDGAVHVWDPFTGKTLRTVEPLDSRVPLTAVAVMPAPHTSITMASSDSTLRFVDCRKPGLQHEFRLGGGLNPGLVRALAISPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIKAVEGSVLVSSSSDHSLTVWKELEQKPTHHYKSASDPIHTFDLYGSEVVTGTVSNKIGVCSLLEPPSQATTKLSSENFRGTLTSLALLPTKRHLLLGSDNGVIRLLA"},{"id":"SEQ_03202","a":"Q5TC82","g":"RC3H1","d":"Roquin-1","L":1133,"m":[{"c":"PSYx[RP]E","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three clustered 6-aa copies separated by 17-22 aa linkers within the central P/S/Y-enriched disordered region, anchored by invariant N-terminal PSY and C-terminal E residues with [RP] at position 5.","i":[[679,684,"PSYTRE"],[702,707,"PSYVPE"],[730,735,"PSYLRE"]]}],"s":"MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTDIELLPVNSALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVGLNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLSSNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKTSIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAPDQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELLANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCRDMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAAILPDEGAVDLPSRKPPALPNGIVSTGNTVTQLIPRGTDPSYDSSLKPGKIDHLSSSAPGSPPDLLESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAAPPFEPAPYQQGMYYTPPPQCVSRFVRPPPSAPEPAPPYLDHYPPYLQERVVNSQYGTQPQQYPPIYPSHYDGRRVYPAPSYTREEIFRESPIPIEIPPAAVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYSRLPPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSPTLPPTFHPEEFLDEDLKVAGKYKGNDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEMMNVESKGMRDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSKTIYQGAGPMQAMAPQGAPTKSINISDYSPYGTHGGWGASPYSPHQNIPSQGHFSERERISMSEVASHGKPLPSAEREQLRLELQQLNHQISQQTQLRGLEAVSNRLVLQREANTLAGQSQPPPPPPPKWPGMISSEQLSLELHQVEREIGKRTRELSMENQCSLDMKSKLNTSKQAENGQPEPQNKVPAEDLTLTFSDVPNGSALTQENISLLSNKTSSLNLSEDPEGGGDNNDSQRSGVTPSSAP"},{"id":"SEQ_03217","a":"Q96QC0","g":"PPP1R10","d":"Serine/threonine-protein phosphatase 1 regulatory subunit 10","L":940,"m":[{"c":"GHRPHEGPGG[GS][MI][GS]","u":13,"sp":"periodic","x":"disordered_like","cf":"high","why":"Six highly conserved 13-residue repeats in the C-terminal disordered region anchored by an invariant GHRPHEGPGG head and a [GS][MI][GS] aliphatic-containing tail, separated by short 1-3 residue polar/glycine linkers (predominantly 16-aa periodicity).","i":[[750,762,"GHRPHEGPGGGMG"],[766,778,"GHRPHEGPGGGMG"],[780,792,"GHRPHEGPGGSMG"],[796,808,"GHRPHEGPGGGIS"],[812,824,"GHRPHEGPGGGMG"],[828,840,"GHRPHEGPGGSMG"]]},{"c":"HR[PG]H-","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five non-overlapping degenerate histidine-rich pentapeptide repeats immediately C-terminal to the 13-mer array, defined by invariant H1, R2, and H4 anchors, a [PG] choice at position 3, and a conserved C-terminal acidic (D/E) residue across 3-9 residue G/P/H-rich linkers.","i":[[751,755,"HRPHE"],[859,863,"HRPHD"],[867,871,"HRGHD"],[880,884,"HRGHD"],[893,897,"HRGHD"]]}],"s":"MGSGPIDPKELLKGLDSFLNRDGEVKSVDGISKIFSLMKEARKMVSRCTYLNILLQTRSPEILVKFIDVGGYKLLNNWLTYSKTTNNIPLLQQILLTLQHLPLTVDHLKQNNTAKLVKQLSKSSEDEELRKLASVLVSDWMAVIRSQSSTQPAEKDKKKRKDEGKSRTTLPERPLTEVKAETRAEEAPEKKREKPKSLRTTAPSHAKFRSTGLELETPSLVPVKKNASTVVVSDKYNLKPIPLKRQSNVAAPGDATPPAEKKYKPLNTTPNATKEIKVKIIPPQPMEGLGFLDALNSAPVPGIKIKKKKKVLSPTAAKPSPFEGKTSTEPSTAKPSSPEPAPPSEAMDADRPGTPVPPVEVPELMDTASLEPGALDAKPVESPGDPNQLTRKGRKRKSVTWPEEGKLREYFYFELDETERVNVNKIKDFGEAAKREILSDRHAFETARRLSHDNMEEKVPWVCPRPLVLPSPLVTPGSNSQERYIQAEREKGILQELFLNKESPHEPDPEPYEPIPPKLIPLDEECSMDETPYVETLEPGGSGGSPDGAGGSKLPPVLANLMGSMGAGKGPQGPGGGGINVQEILTSIMGSPNSHPSEELLKQPDYSDKIKQMLVPHGLLGPGPIANGFPPGGPGGPKGMQHFPPGPGGPMPGPHGGPGGPVGPRLLGPPPPPRGGDPFWDGPGDPMRGGPMRGGPGPGPGPYHRGRGGRGGNEPPPPPPPFRGARGGRSGGGPPNGRGGPGGGMVGGGGHRPHEGPGGGMGNSSGHRPHEGPGGGMGSGHRPHEGPGGSMGGGGGHRPHEGPGGGISGGSGHRPHEGPGGGMGAGGGHRPHEGPGGSMGGSGGHRPHEGPGHGGPHGHRPHDVPGHRGHDHRGPPPHEHRGHDGPGHGGGGHRGHDGGHSHGGDMSNRPVCRHFMMKGNCRYENNCAFYHPGVNGPPLP"},{"id":"SEQ_03220","a":"Q9NRR4","g":"DROSHA","d":"Ribonuclease 3","L":1374,"m":[{"c":"HN[EQ]RψEFLGD[AS]ψψ[EQ]φψ[TA][ST]xxLΩφxFPxxxEGxL[AT]xφR[ST][AS]ψVoNxxxAxψAxxLxψxxΩφψx(x){14,15}ψAxxφE[AS]φI[GA]AψYψ-xxLExφxoφφxxxφF","u":"105-106","sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 105-106 aa structured domain copies in the C-terminal half separated by a 70 aa linker, anchored by invariant HN..R.EFLGD, L..FP...EG.L...R, and C-terminal E..I.A.Y.-..LE....F motifs with conserved hydrophobic cores and a single 1 aa loop length difference.","i":[[964,1069,"HNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHGPDLCRESDLRHAMANCFEALIGAVYLEGSLEEAKQLFGRLLF"],[1142,1246,"HNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQEYAITNDKTKRPVALRTKTLADLLESFIAALYIDKDLEYVHTFMNVCFF"]]}],"s":"MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQGPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPPSFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYDRGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNHRSPSREKKRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMPDKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECESDEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGPLFEDSPPCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIANMLQWEELEWQKYAEECKGMIVTNPGTKPSSVRIDQLDREQFNPDVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHPSHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMHMRKKGINTLINIMSRLGQDDPTPSRINHNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHGPDLCRESDLRHAMANCFEALIGAVYLEGSLEEAKQLFGRLLFNDPDLREVWLNYPLHPLQLQEPNTDRQLIETSPVLQKLTEFEEAIGVIFTHVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQEYAITNDKTKRPVALRTKTLADLLESFIAALYIDKDLEYVHTFMNVCFFPRLKEFILNQDWNDPKSQLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGERIGCGKGPSIQQAEMGAAMDALEKYNFPQMAHQKRFIERKYRQELKEMRWEREHQEREPDETEDIKK"},{"id":"SEQ_03236","a":"Q15697","g":"ZNF174","d":"Zinc finger protein 174","L":407,"m":[{"c":"+PYxC[DG]xCG[KN][SC]FxxoSxL[KH]xHxRψH[TH]G-","u":28,"sp":"tandem","x":"structured_like","cf":"high","why":"Three contiguous head-to-tail 28-aa repeats at the C-terminus (residues 324-407) defined by strictly conserved CxxCGxxF and LxxHxRψH spacing, an N-terminal +PY anchor, and a C-terminal [TH]G- motif.","i":[[324,351,"KPYKCDDCGKSFTWNSELKRHKRVHTGE"],[352,379,"RPYTCGECGNCFGRQSTLKLHQRIHTGE"],[380,407,"KPYQCGQCGKSFRQSSNLHQHHRLHHGD"]]}],"s":"MAAKMEITLSSNTEASSKQERHIIAKLEEKRGPPLQKNCPDPELCRQSFRRFCYQEVSGPQEALSQLRQLCRQWLQPELHTKEQILELLVMEQFLTILPPEIQARVRHRCPMSSKEIVTLVEDFHRASKKPKQWVAVCMQGQKVLLEKTGSQLGEQELPDFQPQTPRRDLRESSPAEPSQAGAYDRLSPHHWEKSPLLQEPTPKLAGTEAPRMRSDNKENPQQEGAKGAKPCAVSAGRSKGNGLQNPEPRGANMSEPRLSRRQVSSPNAQKPFAHYQRHCRVEYISSPLKSHPLRELKKSKGGKRSLSNRLQHLGHQPTRSAKKPYKCDDCGKSFTWNSELKRHKRVHTGERPYTCGECGNCFGRQSTLKLHQRIHTGEKPYQCGQCGKSFRQSSNLHQHHRLHHGD"},{"id":"SEQ_03260","a":"Q12929","g":"EPS8","d":"Epidermal growth factor receptor kinase substrate 8","L":822,"m":[{"c":"P[AP]xTP[AP][AP][PV][PS]","u":9,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Three clustered proline-rich 9-mer repeats in the C-terminal disordered linker (residues 617-646) anchored by invariant P1 and T4-P5 positions, with copies 2 and 3 sharing near-identical PP[PS]TPAPVPV core sequence.","i":[[617,625,"PADTPPAPS"],[626,634,"PPPTPAPVP"],[638,646,"PPSTPAPVP"]]}],"s":"MNGHISNHPSSFGMYPSQMNGYGSSPTFSQTDREHGSKTSAKALYEQRKNYARDSVSSVSDISQYRVEHLTTFVLDRKDAMITVDDGIRKLKLLDAKGKVWTQDMILQVDDRAVSLIDLESKNELENFPLNTIQHCQAVMHSCSYDSVLALVCKEPTQNKPDLHLFQCDEVKANLISEDIESAISDSKGGKQKRRPDALRMISNADPSIPPPPRAPAPAPPGTVTQVDVRSRVAAWSAWAADQGDFEKPRQYHEQEETPEMMAARIDRDVQILNHILDDIEFFITKLQKAAEAFSELSKRKKNKKGKRKGPGEGVLTLRAKPPPPDEFLDCFQKFKHGFNLLAKLKSHIQNPSAADLVHFLFTPLNMVVQATGGPELASSVLSPLLNKDTIDFLNYTVNGDERQLWMSLGGTWMKARAEWPKEQFIPPYVPRFRNGWEPPMLNFMGATMEQDLYQLAESVANVAEHQRKQEIKRLSTEHSSVSEYHPADGYAFSSNIYTRGSHLDQGEAAVAFKPTSNRHIDRNYEPLKTQPKKYAKSKYDFVARNNSELSVLKDDILEILDDRKQWWKVRNASGDSGFVPNNILDIVRPPESGLGRADPPYTHTIQKQRMEYGPRPADTPPAPSPPPTPAPVPVPLPPSTPAPVPVSKVPANITRQNSSSSDSGGSIVRDSQRHKQLPVDRRKSQMEEVQDELIHRLTIGRSAAQKKFHVPRQNVPVINITYDSTPEDVKTWLQSKGFNPVTVNSLGVLNGAQLFSLNKDELRTVCPEGARVYSQITVQKAALEDSSGSSELQEIMRRRQEKISAAASDSGVESFDEGSSH"},{"id":"SEQ_03276","a":"P14314","g":"PRKCSH","d":"Glucosidase 2 subunit beta","L":528,"m":[{"c":"F[TH]C(x){6,9}IPxxxVNDxφCDCxDG[ST]DE(x){3,4}φφCxN","u":"36-40","sp":"tandem","x":"structured_like","cf":"high","why":"Two tandem cysteine-rich structured repeats (2 aa linker) sharing conserved FxC, IPxxxVNDxφCDCxDG[ST]DE, and φφCxN architecture across 36-40 residues with minor loop length variation.","i":[[37,72,"FTCLDGSATIPFDQVNDDYCDCKDGSDEPGTAACPN"],[75,114,"FHCTNTGYKPLYIPSNRVNDGVCDCCDGTDEYNSGVICEN"]]}],"s":"MLLPLLLLLPMCWAVEVKRPRGVSLTNHHFYDESKPFTCLDGSATIPFDQVNDDYCDCKDGSDEPGTAACPNGSFHCTNTGYKPLYIPSNRVNDGVCDCCDGTDEYNSGVICENTCKEKGRKERESLQQMAEVTREGFRLKKILIEDWKKAREEKQKKLIELQAGKKSLEDQVEMLRTVKEEAEKPEREAKEQHQKLWEEQLAAAKAQQEQELAADAFKELDDDMDGTVSVTELQTHPELDTDGDGALSEAEAQALLSGDTQTDATSFYDRVWAAIRDKYRSEALPTDLPAPSAPDLTEPKEEQPPVPSSPTEEEEEEEEEEEEEAEEEEEEEDSEEAPPPLSPPQPASPAEEDKMPPYDEQTQAFIDAAQEARNKFEEAERSLKDMEESIRNLEQEISFDFGPNGEFAYLYSQCYELTTNEYVYRLCPFKLVSQKPKLGGSPTSLGTWGSWIGPDHDKFSAMKYEQGTGCWQGPNRSTTVRLLCGKETMVTSTTEPSRCEYLMELMTPAACPEPPPEAPTEDDHDEL"},{"id":"SEQ_03296","a":"Q6ZSZ6","g":"TSHZ1","d":"Teashirt homolog 1","L":1077,"m":[{"c":"[FL]xCxxCxxx[FYH]x[ST]xxxφxxH[LM](x){2,4}H","u":"23-25","sp":"dispersed","x":"structured_like","cf":"high","why":"Five dispersed 23-25 aa repeats defined by invariant CxxC and H[LM](x){2,4}H anchors alongside conserved hydrophobic/aromatic ([FL], [FYH], φ) and polar ([ST]) core positions across variable linkers.","i":[[246,270,"FRCKDCSAAYDTLVELTVHMNETGH"],[307,331,"LKCMYCGHSFESLQDLSVHMIKTKH"],[416,440,"LKCMECGSSHDTLQQLTAHMMVTGH"],[970,992,"FFCNDCASQFRTASTYISHLETH"],[1037,1060,"FQCKLCNRTFASKHAVKLHLSKTH"]]}],"s":"MPRRKQQAPRRSAAYVPEEELKAAEIDEEHVEDDGLSLDIQESEYMCNEETEIKEAQSYQNSPVSSATNQDAGYGSPFSESSDQLAHFKGSSSREEKEDPQCPDSVSYPQDSLAQIKAVYANLFSESCWSSLALDLKKSGSTTSTNDASQKESSAPTPTPPTCPVSTTGPTTSTPSTSCSSSTSHSSTTSTSSSSGYDWHQAALAKTLQQTSSYGLLPEPSLFSTVQLYRQNNKLYGSVFTGASKFRCKDCSAAYDTLVELTVHMNETGHYRDDNRDKDSEKTKRWSKPRKRSLMEMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVPAITKLVPSTKKRALQDLAPPCSPEPAGMAAEVALSESAKDQKAANPYVTPNNRYGYQNGASYTWQFEARKAQILKCMECGSSHDTLQQLTAHMMVTGHFLKVTTSASKKGKQLVLDPVVEEKIQSIPLPPTTHTRLPASSIKKQPDSPAGSTTSEEKKEPEKEKPPVAGDAEKIKEESEDSLEKFEPSTLYPYLREEDLDDSPKGGLDILKSLENTVSTAISKAQNGAPSWGGYPSIHAAYQLPGTVKPLPAAVQSVQVQPSYAGGVKSLSSAEHNALLHSPGSLTPPPHKSNVSAMEELVEKVTGKVNIKKEERPPEKEKSSLAKAASPIAKENKDFPKTEEVSGKPQKKGPEAETGKAKKEGPLDVHTPNGTEPLKAKVTNGCNNLGIIMDHSPEPSFINPLSALQSIMNTHLGKVSKPVSPSLDPLAMLYKISNSMLDKPVYPATPVKQADAIDRYYYENSDQPIDLTKSKNKPLVSSVADSVASPLRESALMDISDMVKNLTGRLTPKSSTPSTVSEKSDADGSSFEEALDELSPVHKRKGRQSNWNPQHLLILQAQFASSLRETTEGKYIMSDLGPQERVHISKFTGLSMTTISHWLANVKYQLRRTGGTKFLKNLDTGHPVFFCNDCASQFRTASTYISHLETHLGFSLKDLSKLPLNQIQEQQNVSKVLTNKTLGPLGATEEDLGSTFQCKLCNRTFASKHAVKLHLSKTHGKSPEDHLIYVTELEKQ"},{"id":"SEQ_03305","a":"P16157","g":"ANK1","d":"Ankyrin-1","L":1881,"m":[{"c":"GxTPLHφAAxxGHxxφφxxLψxxGAxxNx(x){0,4}","u":"29-33","sp":"tandem","x":"structured_like","cf":"high","why":"23 head-to-tail tandem copies spanning residues 45-799 (22 canonical 33-aa units and one 29-aa unit lacking the 4-residue C-terminal loop) anchored by GxTPLHφAA, an internal GH dipeptide, a conserved hydrophobic-leucine core (φφxxLψ), and a GAxxN turn motif.","i":[[45,77,"GLNGLHLASKEGHVKMVVELLHKEIILETTTKK"],[78,110,"GNTALHIAALAGQDEVVRELVNYGANVNAQSQK"],[111,143,"GFTPLYMAAQENHLEVVKFLLENGANQNVATED"],[144,172,"GFTPLAVALQQGHENVVAHLINYGTKGKV"],[173,205,"RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT"],[206,238,"GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN"],[239,271,"GITPLHIASRRGNVIMVRLLLDRGAQIETKTKD"],[272,304,"ELTPLHCAARNGHVRISEILLDHGAPIQAKTKN"],[305,337,"GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD"],[338,370,"HLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN"],[371,403,"GFTPLHIACKKNHVRVMELLLKTGASIDAVTES"],[404,436,"GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK"],[437,469,"VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD"],[470,502,"DQTPLHCAARIGHTNMVKLLLENNANPNLATTA"],[503,535,"GHTPLHIAAREGHVETVLALLEKEASQACMTKK"],[536,568,"GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN"],[569,601,"GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN"],[602,634,"GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ"],[635,667,"GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS"],[668,700,"GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRM"],[701,733,"GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL"],[734,766,"GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD"],[767,799,"GTTPLAIAKRLGYISVTDVLKVVTDETSFVLVS"]]}],"s":"MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP"},{"id":"SEQ_03322","a":"O75420","g":"GIGYF1","d":"GRB10-interacting GYF protein 1","L":1035,"m":[{"c":"[AG]x[PG]LWxxxxKSGG[GS]xx","u":16,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Head-to-tail tandem 16-aa duplication in the C-terminal disordered region anchored by invariant LW and KSGG[GS] submotifs (with both copies also followed by a GLGL tetramer across a 1-residue linker length difference).","i":[[821,836,"AGPLWGGPDKSGGGSS"],[837,852,"GLGLWEDTPKSGGSLV"]]}],"s":"MAAETLNFGPEWLRALSGGGSVASPPPSPAMPKYKLADYRYGREEMLALYVKENKVPEELQDKEFAAVLQDEPLQPLALEPLTEEEQRNFSLSVNSVAVLRLMGKGAGPPLAGTSRGRGSTRSRGRGRGDSCFYQRSIEEGDGAFGRSPREIQRSQSWDDRGERRFEKSARRDGARCGFEEGGAGPRKEHARSDSENWRSLREEQEEEEEGSWRLGAGPRRDGDRWRSASPDGGPRSAGWREHGERRRKFEFDLRGDRGGCGEEEGRGGGGSSHLRRCRAPEGFEEDKDGLPEWCLDDEDEEMGTFDASGAFLPLKKGPKEPIPEEQELDFQGLEEEEEPSEGLEEEGPEAGGKELTPLPPQEEKSSSPSPLPTLGPLWGTNGDGDETAEKEPPAAEDDIRGIQLSPGVGSSAGPPGDLEDDEGLKHLQQEAEKLVASLQDSSLEEEQFTAAMQTQGLRHSAAATALPLSHGAARKWFYKDPQGEIQGPFTTQEMAEWFQAGYFSMSLLVKRGCDEGFQPLGEVIKMWGRVPFAPGPSPPPLLGNMDQERLKKQQELAAAALYQQLQHQQFLQLVSSRQLPQCALREKAALGDLTPPPPPPPQQQQQQLTAFLQQLQALKPPRGGDQNLLPTMSRSLSVPDSGRLWDVHTSASSQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQELLLKLLQQQQAVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQLEGERQLHKQPPPREPARAQAPNHRVQLGGLGTAPLNQWVSEAGPLWGGPDKSGGGSSGLGLWEDTPKSGGSLVRGLGLKNSRSSPSLSDSYSHLSGRPIRKKTEEEEKLLKLLQGIPRPQDGFTQWCEQMLHTLSATGSLDVPMAVAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLERRAKQKASQQRQQQQEAWLSSASLQTAFQANHSTKLGPGEGSKAKRRALMLHSDPSILGYSLHGSSGEIESVDDY"},{"id":"SEQ_03325","a":"Q12968","g":"NFATC3","d":"Nuclear factor of activated T-cells, cytoplasmic 3","L":1075,"m":[{"c":"SLSP[RH][QH]SP(x){1,5}HSPR[SG]SVT--[NT]WL","u":"22-26","sp":"dispersed","x":"disordered_like","cf":"high","why":"Strongly conserved 22-26 aa bipartite repeat in the N-terminal disordered region featuring an N-terminal SLSP[RH][QH]SP module and a C-terminal HSPR[SG]SVT--[NT]WL module (15 identical positions plus conserved acidic/basic positions) separated by a 1- vs 5-aa internal linker.","i":[[234,255,"SLSPRQSPCHSPRSSVTDENWL"],[286,311,"SLSPHHSPVPSPGHSPRGSVTEDTWL"]]},{"c":"GxPS[SP]QLQPψxYx[PS][SP]xSG[ST]A[ST][ST][AP]SPAx","u":27,"sp":"dispersed","x":"disordered_like","cf":"high","why":"High-identity 27-aa internal duplication in the C-terminal Pro/Ser-rich disordered tail separated by a 10-aa linker, anchored by 14 identical positions (including GxPSxQLQPψxY and SG[ST]A[ST][ST]xSPA) plus conserved aliphatic and Ser/Thr positions.","i":[[904,930,"GQPSSQLQPITYGPSHSGSATTASPAA"],[941,967,"GPPSPQLQPMPYQSPSSGTASSPSPAT"]]}],"s":"MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPADLEPDDCASIYIFNVDPPPSTLTTPLCLPHHGLPSHSSVLSPSFQLQSHKNYEGTCEIPESKYSPLGGPKPFECPSIQITSISPNCHQELDAHEDDLQINDPEREFLERPSRDHLYLPLEPSYRESSLSPSPASSISSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEETWHQQYGLGHSLSPRQSPCHSPRSSVTDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLNASVHGGSGLGPAVFPFQYCVETDIPLKTRKTSEDQAAILPGKLELCSDDQGSLSPARETSIDDGLGSQYPLKKDSCGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPAHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYNEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGQDGRPQWEVEGKIIREKCQGAHIVLEVPPYHNPAVTAAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEHREEIDLSSVPSLPVPHPAQTQRPSSDSGCSHDSVLSGQRSLICSIPQTYASMVTSSHLPQLQCRDESVSKEQHMIPSPIVHQPFQVTPTPPVGSSYQPMQTNVVYNGPTCLPINAASSQEFDSVLFQQDATLSGLVNLGCQPLSSIPFHSSNSGSTGHLLAHTPHSVHTLPHLQSMGYHCSNTGQRSLSSPVADQITGQPSSQLQPITYGPSHSGSATTASPAASHPLASSPLSGPPSPQLQPMPYQSPSSGTASSPSPATRMHSGQHSTQAQSTGQGGLSAPSSLICHSLCDPASFPPDGATVSIKPEPEDREPNFATIGLQDITLDDVNEIIGRDMSQISVSQGAGVSRQAPLPSPESLDLGRSDGL"},{"id":"SEQ_03333","a":"O00327","g":"BMAL1","d":"Basic helix-loop-helix ARNT-like protein 1","L":626,"m":[{"c":"o-LψGoSxΩ-YφHxxDI[AG][KH]ψxE","u":22,"sp":"dispersed","x":"structured_like","cf":"medium","why":"Two-copy internal domain duplication sharing a 22-residue ungapped conserved core with eight identical anchors (L, G, S, Y, H, D, I, E) and ten physicochemically conserved positions across structured regions separated by ~160 residues.","i":[[185,206,"NDLIGQSLFDYLHPKDIAKVKE"],[366,387,"QELLGTSCYEYFHQDDIGHLAE"]]}],"s":"MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKADRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL"},{"id":"SEQ_03334","a":"Q9NZQ3","g":"NCKIPSD","d":"NCK-interacting protein with SH3 domain","L":722,"m":[{"c":"[ST][STP]x[PI]PP[VQ][PK]RR","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three non-overlapping copies in the central disordered linker anchored by an N-terminal [ST] position, an invariant PP core, constrained [VQ][PK] spacing, and a C-terminal RR basic dyad.","i":[[167,176,"SSQIPPQPRR"],[180,189,"TTPPPPVKRR"],[240,249,"SPTPPPVPRR"]]}],"s":"MYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLEQDVLQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPLPSSQIPPQPRRAAPTTPPPPVKRRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYTSSSPSEPGSSCSPTPPPVPRRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLEALGTLSLGTTEEKAAAEAAVPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQVLLSLVEGKDLSMALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLEELLHILTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLLNIVEDGLPLDTTEQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSEKLLLLLNRGDDPVRIFKHEPQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIADLSPGDKLRMEYLSLMHAIVRTTPYLQHRHRLPDLQAILRRILNEEETSPQCQMDRMIVREMCKEFLVLGEAPS"},{"id":"SEQ_03338","a":"Q9UHG0","g":"DCDC2","d":"Doublecortin domain-containing protein 2","L":476,"m":[{"c":"[ST]ψφψφxNGDxφxx[AG]xRψψIxxKxψooΩ-xφLxxVTxxψoφxxGAV[HR]xψYT(x){17,18}YVA[GV]Gx-xFKKLxY(x){7,10}+RP","u":"92-94","sp":"dispersed","x":"structured_like","cf":"high","why":"Strong N-terminal structured domain duplication (~92-94 aa separated by a 29 aa linker) anchored by conserved NGD, RψψI, ooΩ-xφLxxVT, GAV[HR]xψYT, YVA[GV]Gx-xFKKLxY, and C-terminal +RP motifs alongside conserved hydrophobic core positions.","i":[[18,109,"SVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVTGGVQAPFGAVRNIYTPRTGHRIRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRP"],[140,233,"TIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRP"]]}],"s":"MSGSSARSSHLSQPVVKSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVTGGVQAPFGAVRNIYTPRTGHRIRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVNTEVKPVIHSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDPQRPPRPEVKITSPEENENNQQNKDYAAVA"},{"id":"SEQ_03356","a":"Q63HK3","g":"ZKSCAN2","d":"Zinc finger protein with KRAB and SCAN domains 2","L":967,"m":[{"c":"P[YF]xCxxC[GE]K[CSR]Fxx[SC]xxxxxH[QR][RE][ITV]H[TV][GR]E[KN]","u":28,"sp":"tandem","x":"structured_like","cf":"high","why":"Six head-to-tail 28-residue repeats in the C-terminal region anchored by invariant CxxC and HxxxH coordination pairs, a conserved aromatic position F, and P[YF]...H[TV][GR]E[KN] linker residues (preceded immediately upstream by a degenerate 27-aa relic lacking the CxxC pair).","i":[[774,801,"PYKCGVCGKCFGRSRSLIRHQRIHTGEK"],[802,829,"PFKCLDCGKSFNDSSNFGAHQRIHTGEK"],[830,857,"PYRCGECGKCFSQSSSLIIHQRTHTGEK"],[858,885,"PYQCGECGKSFTNSSHFSAHRRVHTGEN"],[886,913,"PYKCVDCEKSFNNCTRFREHRRIHTGEK"],[914,941,"PYGCAQCGKRFSKSSVLTKHREVHVREK"]]},{"c":"GVHW[SG]YEETKTFL[AD]IL+E[ST]RFYE[TA]LQAC[PH]R[NK]S[QK]ψYGAVAE[WQ]LRECGFLRTPEQCRTKFKSLQKSYRKV+NGHψLE[PS]CAFΩ[EK]-MDALψN","u":88,"sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of an 88-residue structured segment separated by a 69-aa acidic linker, sharing 70/88 identical residues (80% identity) including an invariant 23-aa core (GFLRTPEQCRTKFKSLQKSYRKV) and four conserved cysteines.","i":[[340,427,"GVHWSYEETKTFLAILKESRFYETLQACPRNSQVYGAVAEWLRECGFLRTPEQCRTKFKSLQKSYRKVRNGHMLEPCAFFEDMDALLN"],[497,584,"GVHWGYEETKTFLDILRETRFYEALQACHRKSKLYGAVAEQLRECGFLRTPEQCRTKFKSLQKSYRKVKNGHVLESCAFYKEMDALIN"]]}],"s":"MAVALDSQIDAPLEVEGCLIMKVEKDPEWASEPILEGSDSSETFRKCFRQFCYEDVTGPHEAFSKLWELCCRWLKPEMRSKEQILELLVIEQFLTILPEKIQAWAQKQCPQSGEEAVALVVHLEKETGRLRQQVSSPVHREKHSPLGAAWEVADFQPEQVETQPRAVSREEPGSLHSGHQEQLNRKRERRPLPKNARPSPWVPALADEWNTLDQEVTTTRLPAGSQEPVKDVHVARGFSYRKSVHQIPAQRDLYRDFRKENVGNVVSLGSAVSTSNKITRLEQRKEPWTLGLHSSNKRSILRSNYVKEKSVHAIQVPARSAGKTWREQQQWGLEDEKIAGVHWSYEETKTFLAILKESRFYETLQACPRNSQVYGAVAEWLRECGFLRTPEQCRTKFKSLQKSYRKVRNGHMLEPCAFFEDMDALLNPAARAPSTDKPKEMIPVPRLKRIAISAKEHISLVEEEEAAEDSDDDEIGIEFIRKSEIHGAPVLFQNLSGVHWGYEETKTFLDILRETRFYEALQACHRKSKLYGAVAEQLRECGFLRTPEQCRTKFKSLQKSYRKVKNGHVLESCAFYKEMDALINSRASAPSPSTPEEVPSPSRQERGGIEVEPQEPTGWEPEETSQEAVIEDSCSERMSEEEIVQEPEFQGPPGLLQSPNDFEIGSSIKEDPTQIVYKDMEQHRALIEKSKRVVSQSTDPSKYRKRECISGRQWENLQGIRQGKPMSQPRDLGKAVVHQRPFVGKRPYRLLKYGESFGRSTRLMCRMTHHKENPYKCGVCGKCFGRSRSLIRHQRIHTGEKPFKCLDCGKSFNDSSNFGAHQRIHTGEKPYRCGECGKCFSQSSSLIIHQRTHTGEKPYQCGECGKSFTNSSHFSAHRRVHTGENPYKCVDCEKSFNNCTRFREHRRIHTGEKPYGCAQCGKRFSKSSVLTKHREVHVREKPLPHPPSLYCPENPHKGKTDEFRKTF"},{"id":"SEQ_03361","a":"Q9P203","g":"BTBD7","d":"BTB/POZ domain-containing protein 7","L":1132,"m":[{"c":"φH+Aψψ[AS]AR[CS]PFF+[TN]LLoxxxxxG[AE]EI(x){15,24}φψLHxψYT","u":"50-59","sp":"dispersed","x":"structured_like","cf":"high","why":"Strong 2-copy internal duplication in the structured N-terminal half featuring an 18-residue gapless conserved block (φH+Aψψ[AS]AR[CS]PFF+[TN]LLo with 9 identical anchors including H, AR, PFF, and LL) plus G[AE]EI, a 15-24 aa variable loop, and a C-terminal φψLHxψYT motif.","i":[[155,204,"VHRAILAARCPFFKTLLSSSPEYGAEIIMDINTAGIDMPMFSALLHYLYT"],[276,334,"AHKAVISARSPFFRNLLQRRIRTGEEITDRTLRTPTRIILDESIIPKKYATVILHCMYT"]]}],"s":"MGANASNYPHSCSPRVGGNSQAQQTFIGTSSYSQQGYGCESKLYSLDHGHEKPQDKKKRTSGLATLKKKFIKRRKSNRSADHAKQMRELLSGWDVRDVNALVEEYEGTSALKELSLQASLARPEARTLQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTAGIDMPMFSALLHYLYTGEFGMEDSRFQNVDILVQLSEEFGTPNSLDVDMRGLFDYMCYYDVVLSFSSDSELVEAFGGNQNCLDEELKAHKAVISARSPFFRNLLQRRIRTGEEITDRTLRTPTRIILDESIIPKKYATVILHCMYTDVVDLSVLHCSPSVGSLSEVQALVAGKPNMTRAEEAMELYHIALFLEFNMLAQGCEDIIAESISLDTLIAILKWSSHPYGSKWVHRQALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQASEQDILKYLIKWGEHQLMKRIADREPNLLSGTAHSVNKRGVKRRDLDMEELREILSSLLPFVRIEHILPINSEVLSDAMKRGLISTPPSDMLPTTEGGKSNAWLRQKNAGIYVRPRLFSPYVEEAKSVLDEMMVEQTDLVRLRMVRMSNVPDTLYMVNNAVPQCCHMISHQQISSNQSSPPSVVANEIPVPRLLIMKDMVRRLQELRHTEQVQRAYALNCGEGATVSYEIQIRVLREFGLADAAAELLQNPHKFFPDERFGDESPLLTMRQPGRCRVNSTPPAETMFTDLDSFVAFHPPLPPPPPPYHPPATPIHNQLKAGWKQRPPSQHPSRSFSYPCNHSLFHSRTAPKAGPPPVYLPSVKAAPPDCTSTAGLGRQTVAAAAATTTSTATAAAAAASEKQVRTQPVLNDLMPDIAVGVSTLSLKDRRLPELAVDTELSQSVSEAGPGPPQHLSCIPQRHTHTSRKKHTLEQKTDTRENPQEYPDFYDFSNAACRPSTPALSRRTPSPSQGGYFGPDLYSHNKASPSGLKSAYLPGQTSPKKQEEARREYPLSPDGHLHRQKNEPIHLDVVEQPPQRSDFPLAAPENASTGPAHVRGRTAVETDLTFGLTPNRPSLSACSSEAPEERSGRRLADSESLGHGAQRNTDLEREDSISRGRRSPSKPDFLYKKSAL"},{"id":"SEQ_03371","a":"P35663","g":"CYLC1","d":"Cylicin-1","L":651,"m":[{"c":"xxxS[ST]-x-S[EGD](x){15,19}[KS][KN]xDxKK[DS][VTA]+[KN]","u":"36-40","sp":"tandem","x":"disordered_like","cf":"high","why":"Six head-to-tail 36-40 aa tandem repeats across the central disordered region (292-515, followed immediately by a partial 7th N-terminal motif DTESTDAEFDESS), each combining an acidic/polar S[ST]-x-S[EGD] N-anchor, a 15-19 aa K/D-rich linker, and a conserved [KS][KN]xDxKK[DS][VTA]+[KN] C-terminal motif.","i":[[292,328,"AKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKK"],[329,365,"DTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKK"],[366,402,"YPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKK"],[403,439,"ITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKN"],[440,479,"DEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKK"],[480,515,"NAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARK"]]}],"s":"MSLPRLLKVNIRTYDNSIPISESSRKSWNQKHFALTFPKPLQRGTNDKSRPLKSQITVTRHDKRKLEEGQKPAHKWIRHSFRKILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPPSREKPPLPACEPSLPSPKVRRLCWCKMPPPPPKPRYAPLPEAPWIHKLL"},{"id":"SEQ_03397","a":"Q15542","g":"TAF5","d":"Transcription initiation factor TFIID subunit 5","L":800,"m":[{"c":"[LV]xxφxG[HL](x){10,14}φφφ[STG][GS]xxDxx[VA][RL][LV]W[DSA]xxxxxx","u":"38-42","sp":"dispersed","x":"structured_like","cf":"high","why":"Six C-terminal structural repeats (one N-terminal 38-aa unit followed after a 31-aa linker by five strictly tandem 42-aa units, which also share an internal F[SH][PR] motif) anchored by conserved [LV]xxφxG[HL], a hydrophobic φφφ[STG][GS] strand, invariant D, and a [VA][RL][LV]W signature.","i":[[467,504,"LNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKL"],[536,577,"LKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTC"],[578,619,"LVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQP"],[620,661,"LRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNC"],[662,703,"VRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLM"],[704,745,"VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFE"]]}],"s":"MAALAEEQTEVAVKLEPEGPPTLLPPQAGDGAGEGSGGTTNNGPNGGGGNVAASSSTGGDGGTPKPTVAVSAAAPAGAAPVPAAAPDAGAPHDRQTLLAVLQFLRQSKLREAEEALRREAGLLEEAVAGSGAPGEVDSAGAEVTSALLSRVTASAPGPAAPDPPGTGASGATVVSGSASGPAAPGKVGSVAVEDQPDVSAVLSAYNQQGDPTMYEEYYSGLKHFIECSLDCHRAELSQLFYPLFVHMYLELVYNQHENEAKSFFEKFHGDQECYYQDDLRVLSSLTKKEHMKGNETMLDFRTSKFVLRISRDSYQLLKRHLQEKQNNQIWNIVQEHLYIDIFDGMPRSKQQIDAMVGSLAGEAKREANKSKVFFGLLKEPEIEVPLDDEDEEGENEEGKPKKKKPKKDSIGSKSKKQDPNAPPQNRIPLPELKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVLAAGAYSPQ"},{"id":"SEQ_03413","a":"Q9UIF8","g":"BAZ2B","d":"Bromodomain adjacent to zinc finger domain protein 2B","L":2168,"m":[{"c":"AxφKLLRKLQxQExARxA","u":18,"sp":"tandem","x":"structured_like","cf":"high","why":"Head-to-tail 18-aa tandem duplication sharing 13/18 identical anchor residues (A, KLLRKLQ, QE, AR, A) and a conserved hydrophobic position 3 (A/I), situated immediately N-terminal to an extended E/K/R-rich charged alpha-helical rod.","i":[[881,898,"ADAKLLRKLQAQEIARQA"],[899,916,"AQIKLLRKLQKQEQARVA"]]}],"s":"MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPFNLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTDAHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSSVIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAMESSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQVLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQSSQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEESSLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHPNPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTSGRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPSSKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESDSDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGTSSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKLRQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRAMEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQIKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELRAQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQERERRRQHMMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQKPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQTELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGKLRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQGDEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHSLRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNAGANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTSNVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEFTGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKKWTDTFKVS"},{"id":"SEQ_03419","a":"Q9UFB7","g":"ZBTB47","d":"Zinc finger and BTB domain-containing protein 47","L":747,"m":[{"c":"xxCxxCxxxFxxxxxφxxH(x){3,4}[HC]","u":"23-24","sp":"periodic","x":"structured_like","cf":"high","why":"Nine periodic 23-24 aa repeats separated by regular 3-6 aa linkers (predominantly 5-aa TGEKP-type spacers), defined by strictly invariant Cx2C, F, hydrophobic φ, and H[x3-4][HC] anchor positions.","i":[[436,459,"HPCQKCPRVFNNRWYLEKHMNVTH"],[463,486,"QICDQCGKRFLLESELLLHRQTDC"],[490,513,"IQCVTCGKAFKKLWSLHEHNKIVH"],[520,542,"FSCEICEKKFYTMAHVRKHMVAH"],[548,570,"FTCETCGKSFKRSMSLKVHSLQH"],[576,598,"FRCENCNERFQYKYQLRSHMSIH"],[604,626,"FMCQWCGKDFNMKQYFDEHMKTH"],[632,654,"YICEICGKSFTSRPNMKRHRRTH"],[660,682,"YPCDVCGQRFRFSNMLKAHKEKC"]]}],"s":"MGRLNEQRLFQPDLCDVDLVLVPQRSVFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSLEALAPGGLQQILNFIYTSKLLVNAANVHEVLSAASLLQMADIAASCQELLDARSLGPPGPGTVALAQPAASCTPAAPPYYCDIKQEADTPGLPKIYAREGPDPYSVRVEDGAGTAGGTVPATIGPAQPFFKEEKEGGVEEAGGPPASLCKLEGGEELEEELGGSGTYSRREQSQIIVEVNLNNQTLHVSTGPEGKPGAGPSPATVVLGREDGLQRHSDEEEEDDEEEEEEEEEEEGGGSGREEEEEEEGGSQGEEEEEEEDGHSEQEEEEEEEEEEGPSEQDQESSEEEEGEEGEAGGKQGPRGSRSSRADPPPHSHMATRSRENARRRGTPEPEEAGRRGGKRPKPPPGVASASARGPPATDGLGAKVKLEEKQHHPCQKCPRVFNNRWYLEKHMNVTHSRMQICDQCGKRFLLESELLLHRQTDCERNIQCVTCGKAFKKLWSLHEHNKIVHGYAEKKFSCEICEKKFYTMAHVRKHMVAHTKDMPFTCETCGKSFKRSMSLKVHSLQHSGEKPFRCENCNERFQYKYQLRSHMSIHIGHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPYICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHKEKCFRVSHTLAGDGVPAAPGLPPTQPQAHALPLLPGLPQTLPPPPHLPPPPPLFPTTASPGGRMNANN"},{"id":"SEQ_03421","a":"Q86X29","g":"LSR","d":"Lipolysis-stimulated lipoprotein receptor","L":649,"m":[{"c":"RS[RG]DxxYD","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 8-aa motif instances in the C-terminal P/R/S/D-rich disordered tail (residues 530-585) sharing five strictly invariant anchor positions (R, S, D, Y, D) and a constrained [RG] position.","i":[[529,536,"RSRDDLYD"],[545,552,"RSRDPHYD"],[580,587,"RSGDLPYD"]]}],"s":"MQQDGLGVGTRNGSGKGRSVHPSWPWCAPRPLRYFGRDARARRAQTAAMALLAGGLSRGLGSHPAAAGRDAVVFVWLLLSTWCTAPARAIQVTVSNPYHVVILFQPVTLPCTYQMTSTPTQPIVIWKYKSFCRDRIADAFSPASVDNQLNAQLAAGNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFDQTAWGDSGVYYCSVVSAQDLQGNNEAYAELIVLGRTSGVAELLPGFQAGPIEDWLFVVVVCLAAFLIFLLLGICWCQCCPHTCCCYVRCPCCPDKCCCPEALYAAGKAATSGVPSIYAPSTYAHLSPAKTPPPPAMIPMGPAYNGYPGGYPGDVDRSSSAGGQGSYVPLLRDTDSSVASEVRSGYRIQASQQDDSMRVLYYMEKELANFDPSRPGPPSGRVERAMSEVTSLHEDDWRSRPSRGPALTPIRDEEWGGHSPRSPRGWDQEPAREQAGGGWRARRPRARSVDALDDLTPPSTAESGSRSPTSNGGRSRAYMPPRSRSRDDLYDQDDSRDFPRSRDPHYDDFRSRERPPADPRSHHHRTRDPRDNGSRSGDLPYDGRLLEEAVRKKGSEERRRPHKEEEEEAYYPPAPPPYSETDSQASRERRLKKNLALSRESLVV"},{"id":"SEQ_03425","a":"A0A096LP49","g":"CCDC187","d":"Coiled-coil domain-containing protein 187","L":1063,"m":[{"c":"P[QR]RAW[GT]A(x){14,15}E+x[GS][HP][FP]xQ[RQ]PWS[AS]x[AG]xQx[CA]","u":"40-41","sp":"tandem","x":"disordered_like","cf":"high","why":"Three head-to-tail tandem 40-41 aa repeats (0-1 aa gap) in the central P/Q/R/S-rich disordered region, anchored by conserved N-terminal P[QR]RAW[GT]A and C-terminal E+x[GS][HP][FP]xQ[RQ]PWS[AS]x[AG]xQx[CA] modules flanking a 14-15 aa linker.","i":[[460,499,"PQRAWGAQGQDRSFQRPESPHERLGHFSQRPWSALAGQAC"],[501,540,"PQRAWGAQRQGPSSQRPGSPPEKRSPFPQQPWSAVATQPC"],[541,581,"PRRAWTACETWEDPGPRLRNPLERPSPPAQRPWSSSGVQRA"]]}],"s":"MPTLVVGTPPTCLGDTPQPCHKNSQRQGPFSHGAPGRAADWKAVAKPRLCAPAAEDDVAALRWPGPSQQPDPPWAAPHVVGSDDLKEPGPWGKACSLPMWSTGPEARDGDSSVSSGRLSCSSGGHDVCVSWKERPPQVLGPQQRPRKSDARLEQLRDKIRAQAWQQGSCASLGTSAPSSASRLHKASTLMLRRKGQEAKNPPPAPECSGFSILSAAERRVEAKASHGQGRELSRVSQHQVPVLREKPKRVKSSSCKREKTPKLPSPRRAAKDKHKDEDSELVGVYAWRKGQALVRSLLGPPPVLRRHHSKDPSRDPALTVDLGDSEKVIAAKCSPVCAQLPDATSAYSDQQVSGNTPSLASFDQPATIQTAMAILQDLRQQIQAGLELAQARKGGQELGPSKRRLQDVAGRGCCRDPNAQSSFSKSPWAMTERKHSSLERARSVHTWEPWSSSTARESCPQRAWGAQGQDRSFQRPESPHERLGHFSQRPWSALAGQACSPQRAWGAQRQGPSSQRPGSPPEKRSPFPQQPWSAVATQPCPRRAWTACETWEDPGPRLRNPLERPSPPAQRPWSSSGVQRAGPQGKGRGIGSPVSAAKHALPRPTGSFPQNPLGKEKDTLRPCPRSRGLLGPSHSSESLREFMRQKAQARRRQALEEKASALRTRELRSRRLQEVYRQQREAVLGRAVPVVSRTTPGIVTFVPSSAQSGGLEASGSLESPVLEWSKVTSGMVLGGQEAPGSFCLCLNRAWNHAETLDPPGMGGPQDGRDAPVLLSASPSLGSLELQDLTTRYLPRGMCIYLDPKEAEHLGTSSSLHLRHKQAQLQALETTAKVLKQRVDSLTAKLQGAEALDTVRDPAVGLLRSCPHSLPAAPTLATPTLATPACPGALGPNWGRGAPGEWVSMQPQPLLPPTYFLDGETLSWGPSWEQQQSVSPRAHCESKPRGFPEEGHVDVKPDKRLQRGVAPFQALSPSAGSSYAGPATLHPIWGSLGLEETPSVGGADSVAPCTPRSCGKGDPADRPWAGWSGGRGIHREHLPLPSTRAWPYGVEKSFSTWRASTPRY"},{"id":"SEQ_03466","a":"Q5T5C0","g":"STXBP5","d":"Syntaxin-binding protein 5","L":1151,"m":[{"c":"xxxxφ(x){4,8}xφxxx(x){3,4}[GDA]xψxφφxxx","u":"27-30","sp":"dispersed","x":"structured_like","cf":"high","why":"Seven 27-30 aa structured repeat units sharing three hydrophobic-core segments separated by a 4-8 aa variable loop and a 3-4 aa turn ending in [GDA], anchored C-terminally by an invariant xψxφφxxx motif (typically featuring W/F/Y followed by D/N). Five copies cluster in the N-terminal region with 12-24 aa linkers and two additional copies occur further downstream.","i":[[61,87,"SALAFDPVQKILAVGTQTGALRLFGRP"],[100,128,"AVIQLQFLINEGALVSALADDTLHLWNLR"],[143,172,"ERVTFCHLPFQSKWLYVGTERGNIHIVNVE"],[197,226,"PVVHISDNPMDEGKLLIGFESGTVVLWDLK"],[239,267,"AIHSVAWHHEGKQFICSHSDGTLTIWNVR"],[438,466,"GNWGLGAQSYPEIIITGHADGSVKFWDAS"],[502,531,"YAIQIISWCPESRMLCIAGVSAHVIIYRFS"]]}],"s":"MRKFNIRKVLDGLTAGSSSASQQQQQQHPPGNREPEIQETLQSEHFQLCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFLINEGALVSALADDTLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYVIMWNKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPAKPVQTITPHGKQLKDGKKPEPCKPILKVEFKTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQEPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFADCPVDLIPALYSVGARQKRQGYSKKEWPINGGNWGLGAQSYPEIIITGHADGSVKFWDASAITLQVLYKLKTSKVFEKSRNKDDRPNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVITEVIPMLEVRLLYEINDVETPEGEQPPPLPTPVGGSNPQPIPPQSHPSTSSSSSDGLRDNVPCLKVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLAVNSSYGLVVFGNCNGIAMVDYLQKAVLLNLGTIELYGSNDPYRREPRSPRKSRQPSGAGLCDISEGTVVPEDRCKSPTSGSSSPHNSDDEQKMNNFIEKVKTKSRKFSKMVANDIAKMSRKLSLPTDLKPDLDVKDNSFSRSRSSSVTSIDKESREAISALHFCETFTRKTDSSPSPCLWVGTTLGTVLVIALNLPPGGEQRLLQPVIVSPSGTILRLKGAILRMAFLDTTGCLIPPAYEPWREHNVPEEKDEKEKLKKRRPVSVSPSSSQEISENQYAVICSEKQAKVISLPTQNCAYKQNITETSFVLRGDIVALSNSICLACFCANGHIMTFSLPSLRPLLDVYYLPLTNMRIARTFCFTNNGQALYLVSPTEIQRLTYSQETCENLQEMLGELFTPVETPEAPNRGFFKGLFGGGAQSLDREELFGESSSGKASRSLAQHIPGPGGIEGVKGAASGVVGELARARLALDERGQKLGDLEERTAAMLSSAESFSKHAHEIMLKYKDKKWYQF"},{"id":"SEQ_03474","a":"O15209","g":"ZBTB22","d":"Zinc finger and BTB domain-containing protein 22","L":634,"m":[{"c":"+[IP]ΩxC(x){1,2}C[GNA]K[AK]Fxx+xxxx[RE]Hxxx[HC]","u":"24-25","sp":"periodic","x":"structured_like","cf":"high","why":"Three 24-25 aa repeats separated by regular 3-residue linkers (LNL and TGL), strongly anchored by an N-terminal +[IP]Ω motif, paired cysteines C(x){1,2}C, invariant K and F positions, a conserved basic residue (+), and a C-terminal Hxxx[HC] motif.","i":[[484,507,"KIFLCHCGKAFSHKSMRDRHVNMH"],[511,535,"RPFDCPVCNKKFKMKHHLTEHMKTH"],[539,563,"KPYECGVCAKKFMWRDSFMRHRGHC"]]}],"s":"MEPSPLSPSGAALPLPLSLAPPPLPLPAAAVVHVSFPEVTSALLESLNQQRLQGQLCDVSIRVQGREFRAHRAVLAASSPYFHDQVLLKGMTSISLPSVMDPGAFETVLASAYTGRLSMAAADIVNFLTVGSVLQMWHIVDKCTELLREGRASATTTITTAAATSVTVPGAGVPSGSGGTVAPATMGSARSHASSRASENQSPSSSNYFSPRESTDFSSSSQEAFAASAVGSGERRGGGPVFPAPVVGSGGATSGKLLLEADELCDDGGDGRGAVVPGAGLRRPTYTPPSIMPQKHWVYVKRGGNCPAPTPLVPQDPDLEEEEEEEDLVLTCEDDEDEELGGSSRVPVGGGPEATLSISDVRTLSEPPDKGEEQVNFCESSNDFGPYEGGGPVAGLDDSGGPTPSSYAPSHPPRPLLPLDMQGNQILVFPSSSSSSSSQAPGQPPGNQAEHGAVTVGGTSVGSLGVPGSVGGVPGGTGSGDGNKIFLCHCGKAFSHKSMRDRHVNMHLNLRPFDCPVCNKKFKMKHHLTEHMKTHTGLKPYECGVCAKKFMWRDSFMRHRGHCERRHRLGGVGAVPGPGTPTGPSLPSKRESPGVGGGSGDEASAATPPSSRRVWSPPRVHKVEMGFGGGGGAN"},{"id":"SEQ_03476","a":"Q9BQQ3","g":"GORASP1","d":"Golgi reassembly-stacking protein 1","L":440,"m":[{"c":"[NS]SPAxxAGLxPYxDΩψψ(x){21,23}KPψKLxVΩNxK[ST]xxxREVxVxP[NS]xφWGG[EQ]GxLGx[GS]ψxΩxxφ[HR]R","u":"81-83","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of an 81-83 aa globular-like repeat separated by a 13 aa linker, anchored by an N-terminal [NS]SPAxxAGLxPYxDΩψψ segment, a 21-23 aa variable loop, and a tightly conserved 43 aa C-terminal segment featuring KPψKLxVΩN, REVxVxP, and WGG[EQ]GxLGx[GS]ψxΩxxφ[HR]R motifs.","i":[[25,107,"NSPAQQAGLEPYFDFIITIGHSRLNKENDTLKALLKANVEKPVKLEVFNMKTMRVREVEVVPSNMWGGQGLLGASVRFCSFRR"],[121,201,"SSPAALAGLRPYTDYVVGSDQILQESEDFFTLIESHEGKPLKLMVYNSKSDSCREVTVTPNAAWGGEGSLGCGIGYGYLHR"]]}],"s":"MGLGVSAEQPAGGAEGFHLHGVQENSPAQQAGLEPYFDFIITIGHSRLNKENDTLKALLKANVEKPVKLEVFNMKTMRVREVEVVPSNMWGGQGLLGASVRFCSFRRASEQVWHVLDVEPSSPAALAGLRPYTDYVVGSDQILQESEDFFTLIESHEGKPLKLMVYNSKSDSCREVTVTPNAAWGGEGSLGCGIGYGYLHRIPTQPPSYHKKPPGTPPPSALPLGAPPPDALPPGPTPEDSPSLETGSRQSDYMEALLQAPGSSMEDPLPGPGSPSHSAPDPDGLPHFMETPLQPPPPVQRVMDPGFLDVSGISLLDNSNASVWPSLPSSTELTTTAVSTSGPEDICSSSSSHERGGEATWSGSEFEVSFLDSPGAQAQADHLPQLTLPDSLTSAASPEDGLSAELLEAQAEEEPASTEGLDTGTEAEGLDSQAQISTTE"},{"id":"SEQ_03479","a":"P30260","g":"CDC27","d":"Cell division cycle protein 27 homolog","L":824,"m":[{"c":"xxxxxxxxx[AG]xxxxxxxxxxx[AG]xxx[FLY]xxxxxxx[NP]","u":34,"sp":"dispersed","x":"structured_like","cf":"high","why":"Nine 34 aa helical repeat units (six arranged in a contiguous head-to-tail C-terminal tandem block and three dispersed earlier in the sequence) defined by invariant small [AG] anchors at positions 10 and 22, bulky hydrophobic [FLY] at position 26, hydrophobic packing at positions 6/9/13/32, and a conserved C-terminal P (8/9 copies) turn cap at position 34.","i":[[36,69,"HSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTP"],[113,146,"SACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNP"],[497,530,"NTGWVLCQIGRAYFELSEYMQAERIFSEVRRIEN"],[565,598,"NSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDP"],[599,632,"NYAYAYTLLGHEFVLTEELDKALACFRNAIRVNP"],[633,666,"RHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINP"],[667,700,"QSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDP"],[701,734,"KNPLCKFHRASVLFANEKYKSALQELEELKQIVP"],[735,768,"KESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDP"]]}],"s":"MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSNCLPNSCTTQVPNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSAVISPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALSPLTPSFGILPLETPSPGDGSYLQNYTNTPPVIDVPSTGAPSKKSVARIGQTGTKSVFSQSGNSREVTPILAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGITQPNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYNCKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF"},{"id":"SEQ_03489","a":"P20073","g":"ANXA7","d":"Annexin A7","L":488,"m":[{"c":"[DF]AxxL[RY]xA[MG]xG(x){1,2}GT[DQ]-xxφxxψψxoR[ST]xx[QED]xxx[IT]xxxΩxxxφx+[DT]Lxxxψxx-xSGxφ[ER]x[LG]ψx[AST]ψ","u":"65-66","sp":"dispersed","x":"structured_like","cf":"high","why":"Four highly conserved 65-66 aa globular domain repeats across the C-terminal core (residues 190-485), separated by short 7-18 aa linkers, featuring invariant A, L, G, GT, R, L, SG anchors and a conserved hydrophobic core.","i":[[190,254,"DAEILRKAMKGFGTDEQAIVDVVANRSNDQRQKIKAAFKTSYGKDLIKDLKSELSGNMEELILAL"],[262,326,"DAWSLRKAMQGAGTQERVLIEILCTRTNQEIREIVRCYQSEFGRDLEKDIRSDTSGHFERLLVSM"],[345,410,"DAQRLYQAGEGRLGTDESCFNMILATRSFPQLRATMEAYSRMANRDLLSSVSREFSGYVESGLKTI"],[421,485,"FAERLYYAMKGAGTDDSTLVRIVVTRSEIDLVQIKQMFAQMYQKTLGTMIAGDTSGDYRRLLLAI"]]},{"c":"GYPx[PAF][GP]","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Seven 6-residue repeats in the proline/glycine/tyrosine-rich N-terminal disordered region (forming two head-to-tail tandem clusters at 10-21 and 53-76 plus a dispersed copy at 104-109), anchored by an invariant GYP tripeptide and C-terminal [PAF][GP] positions.","i":[[10,15,"GYPPFP"],[16,21,"GYPPAG"],[53,58,"GYPGAG"],[59,64,"GYPAPG"],[65,70,"GYPAPG"],[71,76,"GYPGAP"],[104,109,"GYPQPP"]]}],"s":"MSYPGYPPTGYPPFPGYPPAGQESSFPPSGQYPYPSGFPPMGGGAYPQVPSSGYPGAGGYPAPGGYPAPGGYPGAPQPGGAPSYPGVPPGQGFGVPPGGAGFSGYPQPPSQSYGGGPAQVPLPGGFPGGQMPSQYPGGQPTYPSQINTDSFSSYPVFSPVSLDYSSEPATVTQVTQGTIRPAANFDAIRDAEILRKAMKGFGTDEQAIVDVVANRSNDQRQKIKAAFKTSYGKDLIKDLKSELSGNMEELILALFMPPTYYDAWSLRKAMQGAGTQERVLIEILCTRTNQEIREIVRCYQSEFGRDLEKDIRSDTSGHFERLLVSMCQGNRDENQSINHQMAQEDAQRLYQAGEGRLGTDESCFNMILATRSFPQLRATMEAYSRMANRDLLSSVSREFSGYVESGLKTILQCALNRPAFFAERLYYAMKGAGTDDSTLVRIVVTRSEIDLVQIKQMFAQMYQKTLGTMIAGDTSGDYRRLLLAIVGQ"},{"id":"SEQ_03497","a":"Q96L73","g":"NSD1","d":"Histone-lysine N-methyltransferase, H3 lysine-36 specific","L":2696,"m":[{"c":"C[FQ]xC(x){7,9}C(x){3,4}Cxxx[FY]Hx-C[LV](x){6,10}[GK]x[FW]xC(x){2,4}C","u":"39-48","sp":"dispersed","x":"structured_like","cf":"high","why":"Four dispersed 39-48 aa cysteine/histidine-rich structured repeats sharing an invariant C4HC3 coordination architecture with fixed [FY]Hx[DE]C[LV] core and [GK]x[FW]x motif preceding the C-terminal C(x){2,4}C pair.","i":[[1546,1586,"CQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNEC"],[1593,1640,"CFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHIC"],[1710,1748,"CFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDC"],[2121,2164,"CFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQC"]]},{"c":"-ψψWφKφxRxxWWPxxIC","u":18,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two widely dispersed 18-aa structured repeats conserved at 13 of 18 positions, anchored by eight identical residues including three tryptophans (W..WWP), K, R, and a C-terminal IC dipeptide.","i":[[325,342,"DLIWAKFKRRPWWPCRIC"],[1758,1775,"EIVWVKVGRYRWWPAEIC"]]},{"c":"[PS]RPQ[PLS][LS]-K","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 8-aa motifs within the C-terminal Pro/Ser-rich disordered region anchored by invariant RPQ and C-terminal [DE]K flanking a short [PLS][LS] core.","i":[[2288,2295,"SRPQPLDK"],[2325,2332,"PRPQLSDK"],[2370,2377,"PRPQSLEK"]]},{"c":"QTLAQ[ST]CWSφG","u":11,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Tandem 11-aa duplication separated by a 2-residue linker near the C-terminus, sharing 9 of 11 identical residues (including a rare CW dipeptide) and conservative [ST] and hydrophobic substitutions at the remaining two positions.","i":[[2643,2653,"QTLAQSCWSAG"],[2656,2666,"QTLAQTCWSLG"]]}],"s":"MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGSADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQLNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQSPWALGKASSRAGLWPIVAGQTLAQSCWSAGSTQTLAQTCWSLGRGQDPKPEQNTLPALNQAPSSHKCAESEQK"},{"id":"SEQ_03499","a":"Q9C0D5","g":"TANC1","d":"Protein TANC1","L":1861,"m":[{"c":"Gx[TPS][AP]LxxAAxxGHxxψVxφLψxxG[AV]xψ(x){6,13}","u":"33-40","sp":"tandem","x":"structured_like","cf":"high","why":"Ten contiguous head-to-tail 33-40 aa structured repeats anchored by invariant L5 and L20, conserved G1, [AP]4, A8-A9, G12-H13, aliphatic/hydrophobic core positions (ψ16-V17, φ19, ψ21), and a C-terminal G[AV]xψ turn, with C-terminal loop extensions in copies 3 and 4.","i":[[935,967,"NAPILCVQSHLGHEEVVTLLLEFGACLDGTSEN"],[968,1000,"GMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKK"],[1001,1040,"GQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHA"],[1041,1078,"LQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLW"],[1079,1111,"GETALTAAAGRGKLEVCELLLGHGAAVSRTNRR"],[1112,1144,"GVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQ"],[1145,1177,"GRTPLMVAACEGHLSTVEFLLSKGAALSSLDKE"],[1178,1210,"GLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN"],[1211,1243,"GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHS"],[1244,1276,"GMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWA"]]},{"c":"SPC[SE]T[LI][STN]S","u":8,"sp":"periodic","x":"disordered_like","cf":"high","why":"Three periodic 8-aa motifs separated by regular 8-9 aa linkers within the N-terminal polar/proline-rich disordered region, anchored by invariant SPC, T5, and S8 residues plus a conserved aliphatic [LI]6 position.","i":[[174,181,"SPCSTLTS"],[190,197,"SPCSTLNS"],[207,214,"SPCETISS"]]}],"s":"MLKAVLKKSREGGKGGKKEAGSDFGPETSPVLHLDHSADSPVSSLPTAEDTYRVSLAKGVSMSLPSSPLLPRQSHLVQSRVNKKSPGPVRKPKYVESPRVPGDAVIMPFREVAKPTEPDEHEAKADNEPSCSPAAQELLTRLGFLLGEGIPSATHITIEDKNETMCTALSQGISPCSTLTSSTASPSTDSPCSTLNSCVSKTAANKSPCETISSPSSTLESKDSGIIATITSSSENDDRSGSSLEWNKDGNLRLGVQKGVLHDRRADNCSPVAEEETTGSAESTLPKAESSAGDGPVPYSQGSSSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPWHNTAGGRAQEVKARFAPYKPQDILLKPLLFEVPSITTDSVFVGRDWLFHQIEENLRNTELAENRGAVVVGNVGFGKTAIISKLVALSCHGSRMRQIASNSPGSSPKTSDPTQDLHFTPLLSPSSSTSASSTAKTPLGSISAENQRPREDAVKYLASKVVAYHYCQADNTYTCLVPEFVHSIAALLCRSHQLAAYRDLLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTNLRNEQKIPEEEYIILIDGLNEAEFHKPDYGDTLSSFITKIISKFPAWLKLIVTVRANFQEIISALPFVKLSLDDFPDNKDIHSDLHAYVQHRVHSSQDILSNISLNGKADATLIGKVSSHLVLRSLGSYLYLKLTLDLFQRGHLVIKSASYKVVPVSLSELYLLQCNMKFMTQSAFERALPILNVALASLHPMTDEQIFQAINAGHIQGEQGWEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTAFLCEPRNGHALLAFMFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFPREGFGEDMRPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELKPKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEEECKQLQRSQQQKQQGPLPAPLNDSENEEDTPTPGLSDHFHSEETEEEETSPQEESVSPTPRSQPSSSVPSSYIRNLQEGLQSKGRPVSPQSRAGIGKSLREPVAQPGLLLQPSKQAQIVKTSQHLGSGQSAVRNGSMKVQISSQNPPPSPMPGRIAATPAGSRTQHLEGTGTFTTRAGCGHFGDRLGPSQNVRLQCGENGPAHPLPSKTKTTERLLSHSSVAVDAAPPNQGGLATCSDVRHPASLTSSGSSGSPSSSIKMSSSTSSLTSSSSFSDGFKVQGPDTRIKDKVVTHVQSGTAEHRPRNTPFMGIMDKTARFQQQSNPPSRSWHCPAPEGLLTNTSSAAGLQSANTEKPSLMQVGGYNNQAKTCSVSTLSASVHNGAQVKELEESKCQIPVHSQENRITKTVSHLYQESISKQQPHISNEAHRSHLTAAKPKRSFIESNV"},{"id":"SEQ_03502","a":"O00468","g":"AGRN","d":"Agrin","L":2068,"m":[{"c":"C(x){5,6}[PTK]VC[GA][SDQ]D[GA]x[TD]Yxx[EDA]Cx[LMR]xxxx[CA]xx[QG]xxψxxxxxG[PQA]C","u":"41-42","sp":"dispersed","x":"structured_like","cf":"high","why":"Nine 41-42 aa cysteine-stabilized modules across the N-terminal half sharing a nearly invariant VC[GA][SDQ]D[GA]x[TD]Yxx[EDA]C signature, a conserved aliphatic core position (ψ), and a C-terminal G[PQA]C motif.","i":[[202,242,"CPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPC"],[276,317,"CRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPC"],[349,389,"CPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQC"],[421,461,"CDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPC"],[494,534,"CSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPC"],[559,599,"CVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPC"],[623,664,"CEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPC"],[709,750,"CQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGAC"],[928,969,"CPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPC"]]},{"c":"φxψxφx[AT]xx[PT][QS]GLψLΩoG(x){5,7}DΩψ[AS]LAψxD[GR][RH]ψ[QE]φ[RS]Ω[DN][LT]G[SK][GQ][PA][AV]Vψ[RT]Sx[VE]PVxx[GN]xWxRψxφxRxxR[RKE]G[TAS]LxV[GD][GDN][EG]x[PR]V[LT]G[ES]SP(x){11,15}LΩψGGxP(x){13,15}G[FL]xG[CA]ψ[RQ][LD]ψxψ[GN][GNR][QRH]xLx[LT]","u":"137-141","sp":"dispersed","x":"structured_like","cf":"high","why":"Three large 137-141 aa globular beta-sandwich domains in the C-terminal half featuring an invariant 63-residue gapless central block (DΩψ...PV[LT]G[ES]SP), flanking GLψLΩoG and LΩψGGxP motifs, and conserved hydrophobic beta-strand cores.","i":[[1396,1532,"LALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLLDVNNQRLEL"],[1664,1804,"LEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPKSRKVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLT"],[1916,2052,"FELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHL"]]},{"c":"PC(x){3,6}PC[FHL][GHN][GA][AG][PST]C(x){8,10}CxCPxG[RF]xG[PAT]xC","u":"34-36","sp":"dispersed","x":"structured_like","cf":"high","why":"Four 34-36 aa six-cysteine modules intercalated between the C-terminal globular domains, anchored by dual N-terminal PC dipeptides and a C-terminal CxCPxG[RF]xG[PAT]xC motif.","i":[[1332,1366,"PCDSQPCFHGGTCQDWALGGGFTCSCPAGRGGAVC"],[1552,1585,"PCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTC"],[1591,1624,"PCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFC"],[1821,1856,"PCTRASGHPCLNGASCVPREAAYVCLCPGGFSGPHC"]]},{"c":"xxC(x){2,4}CxF[GN][AS]xC(x){4,11}CxC","u":"21-28","sp":"dispersed","x":"structured_like","cf":"high","why":"Seven non-overlapping 21-28 aa four-cysteine N-terminal hairpin modules immediately preceding seven of the nine 41-42 aa repeats, defined by a strictly conserved CxF[GN][AS]xC core and C-terminal CxC motif.","i":[[170,197,"DACRGMLCGFGAVCEPNAEGPGRASCVC"],[246,272,"DPCSNVTCSFGSTCARSADGLTASCLC"],[393,416,"DQCPEPCRFNAVCLSRRGRPRCSC"],[466,490,"SPCLGVQCAFGATCAVKNGQAACEC"],[535,555,"DRCGQCRFGALCEAETGRCVC"],[600,620,"ETCGDAVCAFGAVCSAGQCVC"],[899,923,"ATCAEMRCEFGARCVEESGSAHCVC"]]},{"c":"C[QS]C[ND]P[HQ]G[SA][YV][GR][GD][TD]C-[PQ][AM]TG[QL]CSC+PGV[GA]G[LP]+C[DG][RQ]C[EP][PD]G[FR](x){5,12}GC","u":"45-52","sp":"tandem","x":"structured_like","cf":"high","why":"Two head-to-tail tandem 45-52 aa eight-cysteine repeats (separated by a 2-residue TP linker) sharing a 38-residue gapless N-terminal core with high sequence conservation including TG[QL]CSC+PGV[GA]G[LP]+C.","i":[[793,844,"CQCNPHGSYGGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGC"],[847,891,"CSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQCPDGRALGPAGC"]]}],"s":"MAGRSHPGPLRPLLPLLVVAACVLPGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDLVARESLLDGGNKVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELMLNSSLMRITLRNLEEVEFCVEDKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKSPCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALPDPSRSCRVNPRTRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQCPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCGQCRFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVCAFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPTFAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQCPDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQTTPPPSSRPRTTASVPRTTVWPVLTVPPTAPSPAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGGLEPLEGSSVATPGPPVERASCYNSALGCCSDGKTPSLDAEGSNCPATKVFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFRSVRLRDLGPGKSVRAIVDVHFDPTTAFRAPDVARALLRQIQVSRRRSLGVRRPLQEHVRFMDFDWFPAFITGATSGAIAAGATARATTASRLPSSAVTPRAPHPSHTSQPVAKTTAAPTTRRPPTTAPSRVPGRRPPAPQQPPKPCDSQPCFHGGTCQDWALGGGFTCSCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADFNGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPKSRKVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESELANEIPVPETLDSGALHSEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRPCPTP"},{"id":"SEQ_03503","a":"Q07617","g":"SPAG1","d":"Sperm-associated antigen 1","L":926,"m":[{"c":"xxxx[LYF]xx[RE][AG]xxxxxxx[NQK]xxx[ACS]xx[DK][CLY]xx[VAC][LI]xψxxx","u":34,"sp":"dispersed","x":"structured_like","cf":"high","why":"Seven 34-aa helical repeats organized into three tandem clusters dispersed across the sequence, anchored by conserved [RE][AG] in the first helix, [ACS]xx[DK][CLY] in the second helix, and a C-terminal [VAC][LI]xψ hydrophobic packing register.","i":[[241,274,"TVVAYNNRAQAEIKLQNWNSAFQDCEKVLELEPG"],[275,308,"NVKALLRRATTYKHQNKLREATEDLSKVLDVEPD"],[486,519,"LSILYSNRAACYLKEGNCSGCIQDCNRALELHPF"],[520,553,"SMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCG"],[622,655,"TFKALKEEGNQCVNDKNYKDALSKYSECLKINNK"],[656,689,"ECAIYTNRALCYLKLCQFEEAKQDCDQALQLADG"],[690,723,"NVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPS"]]}],"s":"MTTKDYPSLWGFGTTKTFKIPIEHLDFKYIEKCSDVKHLEKILCVLRSGEEGYYPELTEFCEKHLQALAPESRALRKDKPAATAASFTAEEWEKIDGDIKSWVSEIKKEEDKMHFHETETFPAMKDNLPPVRGSNSCLHVGKEKYSKRPTKKKTPRDYAEWDKFDVEKECLKIDEDYKEKTVIDKSHLSKIETRIDTAGLTEKEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSISALPTVVAYNNRAQAEIKLQNWNSAFQDCEKVLELEPGNVKALLRRATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDLKNSEAASETQTKGKRMVIQEIENSEDEEGKSGRKHEDGGGDKKPAEPAGAARAAQPCVMGNIQKKLTGKAEGGKRPARGAPQRGQTPEAGADKRSPRRASAAAAAGGGATGHPGGGQGAENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGLQLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPAKEMISKQAGDSSSHRQQGITDEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIEAKMELEEVTRLLNLKDKTAPFNKEKERRKIEIQEVNEGKEEPGRPAGEVSMGCLASEKGGKSSRSPEDPEKLPIAKPNNAYEFGQIINALSTRKDKEACAHLLAITAPKDLPMFLSNKLEGDTFLLLIQSLKNNLIEKDPSLVYQHLLYLSKAERFKMMLTLISKGQKELIEQLFEDLSDTPNNHFTLEDIQALKRQYEL"},{"id":"SEQ_03506","a":"Q96JM3","g":"CHAMP1","d":"Chromosome alignment-maintaining phosphoprotein 1","L":812,"m":[{"c":"[SF]Pxxx+xxx","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Twenty-six non-overlapping 9-aa motifs across the central disordered region (occurring mostly in tandem or separated by 1-2 aa linkers, with occasional longer gaps containing degenerate copies), strictly anchored by N-terminal [SF]P (often [SF]PE) and a basic residue (+) at position 6, frequently paired with W/R/P at position 5 and P/L at position 9.","i":[[142,150,"SPESPKPTP"],[173,181,"SPEPSKPAS"],[184,192,"SPEPPKSVP"],[204,212,"SPEPQKPAP"],[214,222,"SPESVKATL"],[264,272,"SPESRKSAR"],[275,283,"SPEPRKPSP"],[286,294,"SPEPWKPFP"],[297,305,"SPEPRRPAP"],[308,316,"SPGSWKPGP"],[319,327,"SPRPWKSNP"],[344,352,"SPGPWKPIP"],[355,363,"SPGPWKPTP"],[376,384,"SPSSWKSPP"],[386,394,"SPESWKSGP"],[405,413,"SPEHWKAVP"],[416,424,"SPELRKPGP"],[436,444,"SPELRKPSG"],[452,460,"SPDQRKTSP"],[465,473,"FPESQKSSR"],[476,484,"SPDLWKSSF"],[493,501,"FPETRKPGP"],[531,539,"FPEPAKTAP"],[542,550,"SPEARKRAL"],[551,559,"FPEPRKHAL"],[560,568,"FPELPKSAL"]]},{"c":"[LFY]xCxxCxxxxxxxxxφxxHψ(x){2,6}H","u":"23-27","sp":"dispersed","x":"structured_like","cf":"high","why":"Five C2H2-type zinc finger repeats (two dispersed near the N-terminus and three closely spaced near the C-terminus) sharing an invariant CxxC-x(12)-H-x(3-7)-H chelating architecture with conserved hydrophobic anchors at positions 1, 16, and 20.","i":[[14,37,"LECDHCSFRGTDYENVQIHMGTIH"],[62,85,"FHCHKCFFTSKMYSNVYYHITSKH"],[709,732,"YYCKICCCRAMKKGAVLHHLVNKH"],[738,760,"YKCTICGKAFLLESLLKNHVAAH"],[765,791,"LKCPRCNFESNFPRGFKKHLTHCQSRH"]]}],"s":"MEAFQELRKPSARLECDHCSFRGTDYENVQIHMGTIHPEFCDEMDAGGLGKMIFYQKSAKLFHCHKCFFTSKMYSNVYYHITSKHASPDKWNDKPKNQLNKETDPVKSPPLPEHQKIPCNSAEPKSIPALSMETQKLGSVLSPESPKPTPLTPLEPQKPGSVVSPELQTPLPSPEPSKPASVSSPEPPKSVPVCESQKLAPVPSPEPQKPAPVSPESVKATLSNPKPQKQSHFPETLGPPSASSPESPVLAASPEPWGPSPAASPESRKSARTTSPEPRKPSPSESPEPWKPFPAVSPEPRRPAPAVSPGSWKPGPPGSPRPWKSNPSASSGPWKPAKPAPSVSPGPWKPIPSVSPGPWKPTPSVSSASWKSSSVSPSSWKSPPASPESWKSGPPELRKTAPTLSPEHWKAVPPVSPELRKPGPPLSPEIRSPAGSPELRKPSGSPDLWKLSPDQRKTSPASLDFPESQKSSRGGSPDLWKSSFFIEPQKPVFPETRKPGPSGPSESPKAASDIWKPVLSIDTEPRKPALFPEPAKTAPPASPEARKRALFPEPRKHALFPELPKSALFSESQKAVELGDELQIDAIDDQKCDILVQEELLASPKKLLEDTLFPSSKKLKKDNQESSDAELSSSEYIKTDLDAMDIKGQESSSDQEQVDVESIDFSKENKMDMTSPEQSRNVLQFTEEKEAFISEEEIAKYMKRGKGKYYCKICCCRAMKKGAVLHHLVNKHNVHSPYKCTICGKAFLLESLLKNHVAAHGQSLLKCPRCNFESNFPRGFKKHLTHCQSRHNEEANKKLMEALEPPLEEQQI"},{"id":"SEQ_03507","a":"Q9H5H4","g":"ZNF768","d":"Zinc finger protein 768","L":540,"m":[{"c":"CxxC[GS]Kx[FY]xxxSxLxxH[QAH]RxHxxx+[PT][FY][KSR]","u":28,"sp":"tandem","x":"structured_like","cf":"high","why":"Nine contiguous head-to-tail 28-residue repeats in the C-terminal half anchored by invariant CxxC, K, S, L, HxRxH, and a conserved C-terminal +[PT][FY][KSR] linker, followed immediately by a tenth C-terminal core unit (CDDCGKAFSQSSDLIRHQRTHA) lacking the linker.","i":[[263,290,"CGICGKSFGRGSTLIQHQRIHTGEKPYK"],[291,318,"CEVCSKAFSQSSDLIKHQRTHTGERPYK"],[319,346,"CPRCGKAFADSSYLLRHQRTHSGQKPYK"],[347,374,"CPHCGKAFGDSSYLLRHQRTHSHERPYS"],[375,402,"CTECGKCYSQNSSLRSHQRVHTGQRPFS"],[403,430,"CGICGKSFSQRSALIPHARSHAREKPFK"],[431,458,"CPECGKRFGQSSVLAIHARTHLPGRTYS"],[459,486,"CPDCGKTFNRSSTLIQHQRSHTGERPYR"],[487,514,"CAVCGKGFCRSSTLLQHHRVHSGERPYK"]]},{"c":"xSP[GER]φ[EVA][PSA]","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Twelve 7-residue motifs in the N-terminal P/S/E/Q-rich disordered region anchored by invariant SP, a hydrophobic/aromatic residue at position 5 (predominantly F/Y), and E/V/A + P/S/A, arranged in two tandem blocks (6 and 5 copies separated by a degenerate 7-mer RSPESDS) plus one copy 14 residues C-terminal.","i":[[61,67,"QSPGFEP"],[68,74,"QSPEFEP"],[75,81,"QSPRFEP"],[82,88,"ESPGFES"],[89,95,"RSPGLVP"],[96,102,"PSPEFAP"],[110,116,"QSPEFES"],[117,123,"QSPRYEP"],[124,130,"QSPGYEP"],[131,137,"RSPGYEP"],[138,144,"RSPGYES"],[159,165,"QSPEFEA"]]}],"s":"MEREALPWGLEPQDVQSSDEMRSPEGYLRGNMSENEEEEISQQEGSGDYEVEEIPFGLEPQSPGFEPQSPEFEPQSPRFEPESPGFESRSPGLVPPSPEFAPRSPESDSQSPEFESQSPRYEPQSPGYEPRSPGYEPRSPGYESESSRYESQNTELKTQSPEFEAQSSKFQEGAEMLLNPEEKSPLNISVGVHPLDSFTQGFGEQPTGDLPIGPPFEMPTGALLSTPQFEMLQNPLGLTGALRGPGRRGGRARGGQGPRPNICGICGKSFGRGSTLIQHQRIHTGEKPYKCEVCSKAFSQSSDLIKHQRTHTGERPYKCPRCGKAFADSSYLLRHQRTHSGQKPYKCPHCGKAFGDSSYLLRHQRTHSHERPYSCTECGKCYSQNSSLRSHQRVHTGQRPFSCGICGKSFSQRSALIPHARSHAREKPFKCPECGKRFGQSSVLAIHARTHLPGRTYSCPDCGKTFNRSSTLIQHQRSHTGERPYRCAVCGKGFCRSSTLLQHHRVHSGERPYKCDDCGKAFSQSSDLIRHQRTHAAGRR"},{"id":"SEQ_03524","a":"Q9UJ55","g":"MAGEL2","d":"MAGE-like protein 2","L":1249,"m":[{"c":"[HQK]Pxx[PSA][GR][TAV][PL]Mx","u":10,"sp":"tandem","x":"disordered_like","cf":"high","why":"Large 20-copy tandem 10-mer repeat array in the proline-rich N-terminal disordered region (with one 9-residue degenerate linker unit between copies 16 and 17), anchored by invariant P2 and M9 alongside conserved [HQK]1, G6, and [TAV]7[PL]8 positions.","i":[[101,110,"KPPTPGVLMV"],[111,120,"HPPPPGAPMA"],[121,130,"QPPTPGVLMV"],[131,140,"HPSAPGAPMA"],[141,150,"HPPPPGTPMS"],[151,160,"HPPPPGTPMA"],[161,170,"HPPPPGTPMA"],[171,180,"HPPPPGTPMV"],[181,190,"HPPPPGTPMA"],[191,200,"HPPPPGTPMA"],[201,210,"HPPPPGTPMA"],[211,220,"HPPPPGTPMA"],[221,230,"HPPPPGTPMA"],[231,240,"QPPAPGVLMA"],[241,250,"QPLTPGVLMV"],[251,260,"QPAAPGAPMV"],[270,279,"QPQPSGAPMA"],[280,289,"KPPGPGVLMI"],[290,299,"HPPGARAPMT"],[300,309,"QPPASGAPMA"]]},{"c":"[QP][AG]P[PA][VPL][IV]R","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Contiguous 13-copy head-to-tail 7-mer tandem array in the central disordered region featuring strictly invariant P3 and R7 anchors, aliphatic [IV]6, and tightly constrained [QP]1[AG]2 flanking positions.","i":[[411,417,"QGPPPIR"],[418,424,"PGPPPIR"],[425,431,"PGPPPVR"],[432,438,"QAPPLIR"],[439,445,"QAPPVIR"],[446,452,"QAPPVIR"],[453,459,"QAPPVIR"],[460,466,"QAPAVIR"],[467,473,"QAPPVIR"],[474,480,"QAPPVIR"],[481,487,"QAPPVIR"],[488,494,"QAPPLIR"],[495,501,"QAPPPIR"]]},{"c":"[SG][GDA]WEx[PQ][SN][TAP][SPI][RWQ]x[LS]","u":12,"sp":"tandem","x":"disordered_like","cf":"high","why":"Five consecutive head-to-tail 12-mer repeats preceding the C-terminal globular domain, anchored by an invariant WE dipeptide at positions 3-4 and strong conservation of P6, S7, T8, R10, and L12 across copies.","i":[[920,931,"SDWEVQSPIQVS"],[932,943,"GDWEHPNTPRGL"],[944,955,"SGWEGPSTSRIL"],[956,967,"SGWEGPSASWAL"],[968,979,"SAWEGPSTSRAL"]]},{"c":"xx[GT]WQ[ATV][TP]","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Six contiguous head-to-tail 7-mer repeats immediately N-terminal to the [QP][AG]P[PA][VPL][IV]R array, anchored by an invariant WQ core and constrained [GT]3, [ATV]6, and [TP]7 positions.","i":[[365,371,"PPGWQAT"],[372,378,"SPGWQAT"],[379,385,"QQGWQAT"],[386,392,"PLTWQTT"],[393,399,"QVTWQAP"],[400,406,"AVTWQVP"]]},{"c":"-RR[GTA][SP]SK","u":7,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Three consecutive head-to-tail 7-mer repeats in a polar/charged disordered segment, sharing an invariant RR dipeptide and SK C-terminus flanked by an N-terminal acidic residue.","i":[[727,733,"DRRGSSK"],[734,740,"ERRTSSK"],[741,747,"ERRAPSK"]]}],"s":"MSQLSKNLGDSSPPAEAPKPPVYSRPTVLMRAPPASSRAPPVPWDPPPIDLQASLAAWQAPQPAWEAPQGQLPAPVVPMTQPPALGGPIVPAPPLGGPMGKPPTPGVLMVHPPPPGAPMAQPPTPGVLMVHPSAPGAPMAHPPPPGTPMSHPPPPGTPMAHPPPPGTPMAHPPPPGTPMVHPPPPGTPMAHPPPPGTPMAHPPPPGTPMAHPPPPGTPMAHPPPPGTPMAQPPAPGVLMAQPLTPGVLMVQPAAPGAPMVQPPPAAMMTQPQPSGAPMAKPPGPGVLMIHPPGARAPMTQPPASGAPMAQPAAPPAQPMAPPAQPMASWAPQAQPLILQIQSQVIRAPPQVPQGPQAPPAQLATPPGWQATSPGWQATQQGWQATPLTWQTTQVTWQAPAVTWQVPPPMRQGPPPIRPGPPPIRPGPPPVRQAPPLIRQAPPVIRQAPPVIRQAPPVIRQAPAVIRQAPPVIRQAPPVIRQAPPVIRQAPPLIRQAPPPIRPAPQVLATQPPLWQALPPPPPLRQAPQARLPAPQVQAAPQVPTAPPATQVPAAPPAGPQVPQPVLPAPLSAPLSAPQAVHCPSIIWQAPKGQPPVPHEIPTSMEFQEVQQTQALAWQAQKAPTHIWQPLPAQEAQRQAPPLVQLEQPFQGAPPSQKAVQIQLPPQQAQASGPQAEVPTLPLQPSWQAPPAVLQAQPGPPVAAANFPLGSAKSLMTPSGECRASSIDRRGSSKERRTSSKERRAPSKDRMIFAATFCAPKAVSAARAHLPAAWKNLPATPETFAPSSSVFPATSQFQPASLNAFKGPSAASETPKSLPYALQDPFACVEALPAVPWVPQPNMNASKASQAVPTFLMATAAAPQATATTQEASKTSVEPPRRSGKATRKKKHLEAQEDSRGHTLAFHDWQGPRPWENLNLSDWEVQSPIQVSGDWEHPNTPRGLSGWEGPSTSRILSGWEGPSASWALSAWEGPSTSRALGLSESPGSSLPVVVSEVASVSPGSSATQDNSKVEAQPLSPLDERANALVQFLLVKDQAKVPVQRSEMVKVILREYKDECLDIINRANNKLECAFGYQLKEIDTKNHAYIIINKLGYHTGNLVASYLDRPKFGLLMVVLSLIFMKGNCVREDLIFNFLFKLGLDVRETNGLFGNTKKLITEVFVRQKYLEYRRIPYTEPAEYEFLWGPRAFLETSKMLVLRFLAKLHKKDPQSWPFHYLEALAECEWEDTDEDEPDTGDSAHGPTSRPPPR"},{"id":"SEQ_03563","a":"Q5VZ18","g":"SHE","d":"SH2 domain-containing adapter protein E","L":495,"m":[{"c":"Txφ+RR[GS]SKD[PL]LxK[AP][LP]QLφD[ST]PxEPA-GG[LP]+[SA]E","u":33,"sp":"tandem","x":"disordered_like","cf":"high","why":"Head-to-tail 33-residue internal duplication in the central proline/polar-rich disordered region with 18/33 identical anchors (T, RR, SKD, L, K, QL, D, P, EPA, GG, E) and 4 additional conserved physicochemical positions.","i":[[239,271,"TEIRRRGSKDPLVKALQLLDSPCEPADGGLKSE"],[272,304,"TLAKRRSSKDLLGKPPQLYDTPYEPAEGGPRAE"]]},{"c":"GK[GL]RKNSxA","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 9-residue basic-polar motifs in the N-terminal G/P/A-rich disordered region sharing 7 invariant anchor positions (GK..RKNS.A) and a constrained [GL] third position.","i":[[63,71,"GKLRKNSEA"],[79,87,"GKGRKNSAA"],[117,125,"GKGRKNSRA"]]}],"s":"MQWSPTPGASACLGWASSLACSTAPTLLGRAGRGPLMAAKWFKEFPLNLKTVSERAKPGGGGGKLRKNSEAGGAGPGPGKGRKNSAAELGSGRAGVGPKDSRLSRDSLQGLIQAAAGKGRKNSRATEEEPHRGATKSSGCSTYINRLIKVDTQEKNGKSNYPSSSSSSSSSSSSASSSPSSLGPELDKGKIIKQQETVIILEDYADPYDAKRTKGQRDAERVGENDGYMEPYDAQQMITEIRRRGSKDPLVKALQLLDSPCEPADGGLKSETLAKRRSSKDLLGKPPQLYDTPYEPAEGGPRAEGKARPPDSRLPENDERPAAEYEQPWEWKKEQIVRALSVQFEGAERPSFREETVRQHHRQKSWTQKILKPALSDHSEGEKVDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKYTLNQTSAVFDSIPEVVHYYSNEKLPFKGAEHMTLLYPVHSKLH"},{"id":"SEQ_03576","a":"Q9ULJ3","g":"ZBTB21","d":"Zinc finger and BTB domain-containing protein 21","L":1066,"m":[{"c":"φxCxxCxxxφxxxxxxxxH(x){3,4}[HC]","u":"23-24","sp":"dispersed","x":"structured_like","cf":"high","why":"Nine C2H2/C2HC-type zinc finger repeats distributed as short clusters (3-5 aa linkers) and dispersed singletons (29-110 aa linkers) across the C-terminal half, anchored by invariant CxxC and H-(x)3-4-[HC] coordination motifs plus conserved hydrophobic beta-hairpin and core positions.","i":[[546,569,"FKCKHCLKIFRSTAGLHRHVNMYH"],[575,598,"YACDICHKRFHTNFKVWTHCQTQH"],[670,692,"YICTYCGKAYRFLSQFKQHIKMH"],[722,744,"YQCRLCNAKLSSLLEQGSHERLC"],[748,770,"AVCPYCSLRFFSPELKQEHESKC"],[775,798,"LTCLECMRTFKSSFSIWRHQVEVH"],[909,932,"WPCEKCGKMFTVHKQLERHQELLC"],[937,959,"FICHVCNKAFRTNFRLWSHFQSH"],[1043,1065,"FMCKLCHRTFKTAFSLWSHEQTH"]]}],"s":"MEGLLHYINPAHAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTNKENESQTVFQLDFCEPDAFDNVLNYIYSSSLFVEKSSLAAVQELGYSLGISFLTNIVSKTPQAPFPTCPNRKKVFVEDDENSSQKRSVIVCQSRNEAQGKTVSQNQPDVSHTSRPSPSIAVKANTNKPHVPKPIEPLHNLSLTEKSWPKDSSVVYAKSLEHSGSLDDPNRISLVKRNAVLPSKPLQDREAMDDKPGVSGQLPKGKALELALKRPRPPVLSVCSSSETPYLLKETNKGNGQGEDRNLLYYSKLGLVIPSSGSGSGNQSIDRSGPLVKSLLRRSLSMDSQVPVYSPSIDLKSSQGSSSVSSDAPGNVLCALSQKSSLKDCSEKTALDDRPQVLQPHRLRSFSASQSTDREGASPVTEVRIKTEPSSPLSDPSDIIRVTVGDAATTAAASSSSVTRDLSLKTEDDQKDMSRLPAKRRFQADRRLPFKKLKVNEHGSPVSEDNFEEGSSPTLLDADFPDSDLNKDEFGELEGTRPNKKFKCKHCLKIFRSTAGLHRHVNMYHNPEKPYACDICHKRFHTNFKVWTHCQTQHGIVKNPSPASSSHAVLDEKFQRKLIDIVREREIKKALIIKLRRGKPGFQGQSSSQAQQVIKRNLRSRAKGAYICTYCGKAYRFLSQFKQHIKMHPGEKPLGVNKVAKPKEHAPLASPVENKEVYQCRLCNAKLSSLLEQGSHERLCRNAAVCPYCSLRFFSPELKQEHESKCEYKKLTCLECMRTFKSSFSIWRHQVEVHNQNNMAPTENFSLPVLDHNGDVTGSSRPQSQPEPNKVNHIVTTKDDNVFSDSSEQVNFDSEDSSCLPEDLSLSKQLKIQVKEEPVEEAEEEAPEASTAPKEAGPSKEASLWPCEKCGKMFTVHKQLERHQELLCSVKPFICHVCNKAFRTNFRLWSHFQSHMSQASEESAHKESEVCPVPTNSPSPPPLPPPPPLPKIQPLEPDSPTGLSENPTPATEKLFVPQESDTLFYHAPPLSAITFKRQFMCKLCHRTFKTAFSLWSHEQTHN"},{"id":"SEQ_03577","a":"Q96RT7","g":"TUBGCP6","d":"Gamma-tubulin complex component 6","L":1819,"m":[{"c":"G[HQ]VS[DNG][ATG][SG][IL][RSP]xG-x[VA]S-ψ[AV][PS][TAI][RQ][PS]R[WC]N[TI]H","u":27,"sp":"tandem","x":"disordered_like","cf":"high","why":"Nine head-to-tail 27-aa tandem repeats (residues 1027-1269) within the central proline/polar-rich disordered region, anchored by invariant G1, V3, S4, G11, S15, R23, N25, H27 and conserved acidic/aliphatic positions (G-x[VA]S-ψ[AV]) followed by a [PS][TAI][RQ][PS]R[WC]N[TI]H motif (with an additional partial divergent remnant GSISVGENVSDVAPTQPWWPNT 71 aa downstream).","i":[[1027,1053,"GQVSGGGLPTGDYASEIAPTRPRWNTH"],[1054,1080,"GHVSDASIRVGENVSDVAPTQPRWNTH"],[1081,1107,"GHVSNASISLGESVSDVAPTRPRWNIH"],[1108,1134,"GHVSNASIRVGENVSDVAPTRPRWNTH"],[1135,1161,"GHVSNASIRVGENVSDVAPTRPRWNTH"],[1162,1188,"GHVSDASISLGESVSDMAPARPRWNTH"],[1189,1215,"GHVSDASISLGESVSDMAPTRPRWNTH"],[1216,1242,"GHVSDTSIRVGENVSDVAPIRSRCNTH"],[1243,1269,"GHVSDASISLGEPVSDVVSTRPRWNTH"]]}],"s":"MASITQLFDDLCEALLPAAKTHLGQRSVNRKRAKRSLKKVAYNALFTNLFQDETQQLQPDMSKLPARNKILMLSFDLRVGGLGPKADRLEELVEELEAAPCCPLLEVGSVLDLLVQLAGSGPPQVLPRKRDYFLNNKHVGRNVPYSGYDCDDLSVFEMDVQSLISREECLCHSMIQETLQVMEAAPGTGLPTVGLFSFGDPCGDRFERDTRVSLFGALVHSRTYDMDVRLGLPPVPDNADLSGLAIKVPPSVDQWEDEGFQSASNLTPDSQSEPSVTPDVDLWEAALTYEASKRRCWERVGCPPGHREEPYLTEAGRDAFDKFCRLHQGELQLLAGGVLQAPQPVLVKECELVKDVLNVLIGVVSATFSLCQPAQAFVVKRGVHVSGASPESISSLLSEVAEYGTCYTRLSHFSLQPVLDSLYSKGLVFQAFTSGLRRYLQYYRACVLSTPPTLSLLTIGFLFKKLGRQLRYLAELCGVGAVLPGTCGGGPRAAFPTGVKLLSYLYQEALHNCSNEHYPVLLSLLKTSCEPYTRFIHDWVYSGVFRDAYGEFMIQVNHEYLSFRDKLYWTHGYVLISKEVEDCVPVFLKHIAHDIYVCGKTINLLKLCCPRHYLCWSDVPVPRISVIFSLEELKEIEKDCAVYVGRMERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDVLLSVHPQVTSPGPEHPEGGQGCDSGSAEQHSPAWDGWNRPGLLTPQPLKPLAVGAGGRGLQQAEGARPFSDSLSIGDFLPVGPGAEPSVQTGMVPLLEVALQTINLDLPPSAPGEAPAAASTQPSRPQEYDFSTVLRPAVATSPAPGPLQAAECSLGSSGLQLWEDSCGKMDACGSASRETLLPSHPPRRAALEEGSSQPTERLFGQVSGGGLPTGDYASEIAPTRPRWNTHGHVSDASIRVGENVSDVAPTQPRWNTHGHVSNASISLGESVSDVAPTRPRWNIHGHVSNASIRVGENVSDVAPTRPRWNTHGHVSNASIRVGENVSDVAPTRPRWNTHGHVSDASISLGESVSDMAPARPRWNTHGHVSDASISLGESVSDMAPTRPRWNTHGHVSDTSIRVGENVSDVAPIRSRCNTHGHVSDASISLGEPVSDVVSTRPRWNTHVPIPPPHMVLGALSPEAEPNTPRPQQSPPGHTSQSALSLGAQSTVLDCGPRLPVEVGPSLSSPSSGCGEGSISVGENVSDVAPTQPWWPNTPGDSVSEELGPGRSGDTEDLSPNWPLNSQEDTAAQSSPGRGEEAEASAAEAQGGEQAYLAGLAGQYHLERYPDSYESMSEPPIAHLLRPVLPRAFAFPVDPQVQSAADETAVQLSELLTLPVLMKRSITAPLAAHISLVNKAAVDYFFVELHLEAHYEALRHFLLMEDGEFAQSLSDLLFEKLGAGQTPGELLNPLVLNSVLSKALQCSLHGDTPHASNLSLALKYLPEVFAPNAPDVLSCLELRYKVDWPLNIVITEGCVSKYSGVFSFLLQLKLMMWALKDVCFHLKRTALLSHMAGSVQFRQLQLFKHEMQHFVKVIQGYIANQILHVTWCEFRARLATVGDLEEIQRAHAEYLHKAVFRGLLTEKAAPVMNVIHSIFSLVLKFRSQLISQAWGPPGGPRGAEHPNFALMQQSYNTFKYYSHFLFKVVTKLVNRGYQPHLEDFLLRINFNNYYQDA"},{"id":"SEQ_03597","a":"Q9P1Y5","g":"CAMSAP3","d":"Calmodulin-regulated spectrin-associated protein 3","L":1249,"m":[{"c":"PE[GT][PT]SKP[SL]","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three clustered copies of an 8-residue motif in the central proline/serine-rich disordered region share five invariant anchors (P1, E2, S5, K6, P7) and constrained two-residue choices at the remaining positions, separated by variable 7- and 12-residue Tyr/Pro-containing linkers.","i":[[488,495,"PEGPSKPS"],[502,509,"PEGTSKPL"],[523,530,"PETPSKPS"]]}],"s":"MVEAAPPGPGPLRRTFLVPEIKSLDQYDFSRAKAAASLAWVLRAAFGGAEHVPPELWEPFYTDQYAQEHVKPPVTRLLLSAELYCRAWRQALPQLETPPNPSALLALLARRGTVPALPERPVREADLRHQPILMGAHLAVIDALMAAFAFEWTKTLPGPLALTSLEHKLLFWVDTTVRRLQEKTEQEAAQRASPAAPADGAAPAQPSIRYRKDRVVARRAPCFPTVTSLQDLASGAALAATIHCYCPQLLRLEEVCLKDPMSVADSLYNLQLVQDFCASRLPRGCPLSLEDLLYVPPPLKVNLVVMLAELFMCFEVLKPDFVQVKDLPDGHAASPRGTEASPPQNNSGSSSPVFTFRHPLLSSGGPQSPLRGSTGSLKSSPSMSHMEALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLGPPRPAPARTPTQPPPEPGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGPSKPSLASPYLPEGTSKPLSDRPTKAPVYMPHPETPSKPSPCLVGEASKPPAPSEGSPKAVASSPAATNSEVKMTSFAERKKQLVKAEAEAGAGSPTSTPAPPEALSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREASGEAEAEAEEADSGPVPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRSPKHTRPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDSLEEEASSEGEPRVGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEVEKEQRREEAARLAQEEAPGPAPLVSAVPMATPAPAARAPAEEEVGPRKGDFTRQEYERRAQLKLMDDLDKVLRPRAAGSGGPGRGGRRATRPRSGCCDDSALARSPARGLLGSRLSKIYSQSTLSLSTVANEAHNNLGVKRPTSRAPSPSGLMSPSRLPGSRERDWENGSNASSPASVPEYTGPRLYKEPSAKSNKFIIHNALSHCCLAGKVNEPQKNRILEEIEKSKANHFLILFRDSSCQFRALYTLSGETEELSRLAGYGPRTVTPAMVEGIYKYNSDRKRFTQIPAKTMSMSVDAFTIQGHLWQGKKPTTPKKGGGTPK"},{"id":"SEQ_03618","a":"O00750","g":"PIK3C2B","d":"Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta","L":1634,"m":[{"c":"[PT]P[PQ]ψPPR","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 7-residue proline-rich repeats in the N-terminal disordered region anchored by invariant P2, P5, P6, and C-terminal R7 residues, with tightly constrained [PT]1, [PQ]3, and large aliphatic (L/V) at position 4.","i":[[156,162,"PPPLPPR"],[168,174,"TPPLPPR"],[281,287,"PPQVPPR"]]}],"s":"MSSTQGNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHDKEENRAKQNADPSLISWDEPGVDFYSKPAGRRTDLKLLRGLSGSDPTLNYNSLSPQEGPPNHSTSQGPQPGSDPWPKGSLSGDYLYIFDGSDGGVSSSPGPGDIEGSCKKLSPPPLPPRASIWDTPPLPPRKGSPSSSKISQPSDINTFSLVEQLPGKLLEHRILEEEEVLGGGGQGRLLGSVDYDGINDAITRLNLKSTYDAEMLRDATRGWKEGRGPLDFSKDTSGKPVARSKTMPPQVPPRTYASRYGNRKNATPGKNRRISAAPVGSRPHTVANGHELFEVSEERDEEVAAFCHMLDILRSGSDIQDYFLTGYVWSAVTPSPEHLGDEVNLKVTVLCDRLQEALTFTCNCSSTVDLLIYQTLCYTHDDLRNVDVGDFVLKPCGLEEFLQNKHALGSHEYIQYCRKFDIDIRLQLMEQKVVRSDLARTVNDDQSPSTLNYLVHLQERPVKQTISRQALSLLFDTYHNEVDAFLLADGDFPLKADRVVQSVKAICNALAAVETPEITSALNQLPPCPSRMQPKIQKDPSVLAVRENREKVVEALTAAILDLVELYCNTFNADFQTAVPGSRKHDLVQEACHFARSLAFTVYATHRIPIIWATSYEDFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLPRETLLCATLYALPIPPPGSSSEANKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGLWPATQENPSARWSAPNFHQPDSVILQIDFPTSAFDIKFTSPPGDKFSPRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLWEKRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNFFIHNLAQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIFHPNKGYIYVVKVMRENTHEATYIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGRSRGEAVAERRREELNGYIWHLIHAPPEVAECDLVYTFFHPLPRDEKAMGTSPAPKSSDGTWARPVGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEKTGWFALGSRSHGTL"},{"id":"SEQ_03631","a":"F8W0I5","g":"NPIPB12","d":"Nuclear pore complex-interacting protein family member B12","L":928,"m":[{"c":"SADDN[LI]KT[PR][PSA]E[CR][VLQ][LR][THG]PLPP","u":19,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Fourteen highly conserved 19-aa proline-rich units anchored by invariant SADDN, KT, E, and C-terminal PLPP motifs, separated by 0, 4, or 8-aa SAPP linkers in two blocks flanking the central 40-aa repeat array.","i":[[277,295,"SADDNLKTPPECVLTPLPP"],[296,314,"SADDNLKTPPECLLTPLPP"],[315,333,"SADDNLKTPPECLLTPLPP"],[334,352,"SADDNLKTPPECLLTPLPP"],[361,379,"SADDNLKTRAECLLHPLPP"],[380,398,"SADDNLKTPSERQLTPLPP"],[403,421,"SADDNIKTPAERLRGPLPP"],[422,440,"SADDNLKTPSERQLTPLPP"],[672,690,"SADDNLKTPSERQLTPLPP"],[695,713,"SADDNIKTPAERLRGPLPP"],[714,732,"SADDNLKTPSERQLTPLPP"],[737,755,"SADDNIKTPAERLRGPLPP"],[756,774,"SADDNLKTPSERQLTPLPP"],[779,797,"SADDNIKTPAERLRGPLPP"]]},{"c":"FH[PH]Q[RP]MIISRHLPSVSSLPFHPQLH[PS]QQMIISR[HY]L[PL]SVCG","u":40,"sp":"tandem","x":"mixed","cf":"high","why":"Five nearly identical 40-aa tandem repeats separated by 2-aa [FG]R linkers in the central region, containing two related internal FHPQ...MIISRHLPSV sub-motifs and invariant C-terminal SVCG.","i":[[455,494,"FHPQRMIISRHLPSVSSLPFHPQLHSQQMIISRYLLSVCG"],[497,536,"FHHQPMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCG"],[539,578,"FHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCG"],[581,620,"FHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCG"],[623,662,"FHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCG"]]},{"c":"[RP][KE]PKR[RQ]R[AV][AG]-ψEP[SP]","u":14,"sp":"tandem","x":"disordered_like","cf":"high","why":"Seven C-terminal 14-aa tandem repeats (0-1 aa spacing) alternating between PEPKRRRVGDVEPS and RKPKRRRAADVEPS variants around fixed PKR[RQ]R basic cores and acidic-proline [-ψEP] C-termini.","i":[[819,832,"RKPKRQRAAEMEPP"],[833,846,"PEPKRRRVGDVEPS"],[847,860,"RKPKRRRAADVEPS"],[862,875,"PEPKRRRVGDVEPS"],[876,889,"RKPKRRRAADVEPS"],[891,904,"PEPKRRRVGDVEPS"],[905,918,"RKPKRRRAADVEPS"]]}],"s":"MVKLSIVLTPQFLSHDQGQLTKELQQHVKSVTCPCEYLRKVINTLADHHHRGTDFGGSPWLHVIIAFPTSYKVVITLWIVYLWVSLLKTIFWSRNGHDGSTDVQQRAWRSNRRRQEGLRSICMHTKKRVSSFRGNKIGLKDVITLRRHVETKVRAKIRKRKVTTKINHHDKINGKRKTARKQKMFQRAQELRRRAEDYHKCKIPPSARKALCNWVRMAAAEHRHSSGLPYWPYLTAETLKNRMGHQPPPPTQQHSITDNSLSLKTPPECVLTPLPPSADDNLKTPPECVLTPLPPSADDNLKTPPECLLTPLPPSADDNLKTPPECLLTPLPPSADDNLKTPPECLLTPLPPSAPPSAPPSADDNLKTRAECLLHPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAFHPQRMIISRHLPSVSSLPFHPQLHSQQMIISRYLLSVCGFRFHHQPMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPPLATQEAEAEKPRKPKRQRAAEMEPPPEPKRRRVGDVEPSRKPKRRRAADVEPSSPEPKRRRVGDVEPSRKPKRRRAADVEPSSPEPKRRRVGDVEPSRKPKRRRAADVEPSLPEPKRRRLS"},{"id":"SEQ_03654","a":"Q8NDZ2","g":"SIMC1","d":"SUMO-interacting motif-containing protein 1","L":872,"m":[{"c":"[PKL][RQA][APE][LSV][PS]CP","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Seven copies of a proline-rich 7-mer motif anchored by an invariant C-terminal [PS]CP tripeptide and conserved N-terminal P/R/Q/A/L/S positions within a central disordered region; five copies (residues 197-231) form a contiguous head-to-tail tandem array flanked by two copies separated by 7-aa and 14-aa linkers.","i":[[183,189,"KAPLPCP"],[197,203,"PQALPCP"],[204,210,"LRPLPCP"],[211,217,"PRASPCP"],[218,224,"PRASSCP"],[225,231,"PRALSCP"],[246,252,"PQEVPCP"]]},{"c":"xDψxx[SL][PS]","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Eight non-overlapping 7-mer repeats in the central disordered region defined by an invariant D followed by a large aliphatic residue (V/M/I) and a C-terminal [SL][PS] dipeptide, arranged in tandem sub-blocks (3-copy and 4-copy contiguous arrays) separated by degenerate 6-7 aa repeat-like linkers (including QDSLGLP and GGMPHLP).","i":[[268,274,"QDVPGLP"],[287,293,"QDMPRSP"],[294,300,"GDVPQSP"],[301,307,"SDVSPSP"],[321,327,"GDVLHSP"],[328,334,"GDMPHSS"],[335,341,"GDVTHSP"],[342,348,"RDIPHLP"]]},{"c":"[IL]DLT[RL][EA]","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three closely spaced copies of a conserved 6-residue motif in the N-terminal disordered tail (residues 27-66, separated by 13-aa and 9-aa linkers) featuring a fixed DLT core flanked by aliphatic [IL], [RL], and [EA] positions.","i":[[27,32,"IDLTRE"],[46,51,"IDLTRA"],[61,66,"LDLTLE"]]}],"s":"MAPASASGEDLRKLPTMAEVNGEQDFIDLTRETRPRTKDRSGLYVIDLTRAEGENRPIATLDLTLEPVTPSQKEPTSLQTCASLSGKAVMEGHVDRSSQPTARRIINSDPVDLDLVEENTFVGPPPATSISGGSVYPTEPNCSSATFTGNLSFLASLQLSSDVSSLSPTSNNSRSSSSSSNQKAPLPCPQQDVSRPPQALPCPLRPLPCPPRASPCPPRASSCPPRALSCPSQTMQCQLPALTHPPQEVPCPRQNIPGPPQDSLGLPQDVPGLPQSILHPQDVAYLQDMPRSPGDVPQSPSDVSPSPDAPQSPGGMPHLPGDVLHSPGDMPHSSGDVTHSPRDIPHLPGDRPDFTQNDVQNRDMPMDISALSSPSCSPSPQSETPLEKVPWLSVMETPARKEISLSEPAKPGSAHVQSRTPQGGLYNRPCLHRLKYFLRPPVHHLFFQTLIPDKDTRENKGQKLEPIPHRRLRMVTNTIEENFPLGTVQFLMDFVSPQHYPPREIVAHIIQKILLSGSETVDVLKEAYMLLMKIQQLHPANAKTVEWDWKLLTYVMEEEGQTLPGRVLFLRYVVQTLEDDFQQTLRRQRQHLQQSIANMVLSCDKQPHNVRDVIKWLVKAVTEDGLTQPPNGNQTSSGTGILKASSSHPSSQPNLTKNTNQLIVCQLQRMLSIAVEVDRTPTCSSNKIAEMMFGFVLDIPERSQREMFFTTMESHLLRCKVLEIIFLHSCETPTRLPLSLAQALYFLNNSTSLLKCQSDKSQWQTWDELVEHLQFLLSSYQHVLREHLRSSVIDRKDLIIKRIKPKPQQGDDITVVDVEKQIEAFRSRLIQMLGEPLVPQLQDKVHLLKLLLFYAADLNPDAEPFQKGWSGS"},{"id":"SEQ_03657","a":"B2RTY4","g":"MYO9A","d":"Unconventional myosin-IXa","L":2548,"m":[{"c":"[ARK]xφx[LI]Qxx[WFC]+xxxxx[QKR][RHQ]φ","u":18,"sp":"periodic","x":"structured_like","cf":"high","why":"Six contiguous amphipathic helical repeats (residues 1022-1158, mostly spaced by 5-aa linkers for a ~23-aa period) anchored by an invariant Q at position 6, preceded by a conserved hydrophobic [LI]xφ core and followed by [WFC]+ at positions 9-10 and polar/basic-hydrophobic [QKR][RHQ]φ at positions 16-18.","i":[[1022,1039,"RIILLQRWFRVLLCRQHF"],[1045,1062,"ASVIIQRFWRNYLNQKQV"],[1077,1094,"AAALLQASWRAHLERQRY"],[1100,1117,"AAIVIQQKWRDYYRRRHM"],[1118,1135,"AAICIQARWKAYRESKRY"],[1141,1158,"KIILLQSTCRGFRARQRF"]]}],"s":"MNINDGGRRRFEDNEHTLRIYPGAISEGTIYCPIPARKNSTAAEVIESLINKLHLDKTKCYVLAEVKEFGGEEWILNPTDCPVQRMMLWPRMALENRLSGEDYRFLLREKNLDGSIHYGSLQSWLRVTEERRRMMERGFLPQPQQKDFDDLCSLPDLNEKTLLENLRNRFKHEKIYTYVGSILIVINPFKFLPIYNPKYVKMYDNHQLGKLEPHIYAVADVAYHAMLQRKKNQCIVISGESGSGKTQSTNFLIHHLTALSQKGFASGVEQIILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYQETGTVLGAYVEKYLLEKSRLVYQEHNERNYHVFYYLLAGASEDERSAFHLKQPEEYHYLNQITKKPLRQSWDDYCYDSEPDCFTVEGEDLRHDFERLQLAMEMVGFLPKTRRQIFSLLSAILHLGNICYKKKTYRDDSIDICNPEVLPIVSELLEVKEEMLFEALVTRKTVTVGEKLILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDLEHNTKTLSIGVLDIFGFEDYENNSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYIDNTCCINLISKKPTGLLHLLDEESNFPQATNQTLLDKFKHQHEDNSYIEFPAVMEPAFIIKHYAGKVKYGVKDFREKNTDHMRPDIVALLRSSKNAFISGMIGIDPVAVFRWAILRAFFRAMVAFREAGKRNIHRKTGHDDTAPCAILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSDLQGMNALNEKNQHDTFDIAWNGRTGIRQSRLSSGTSLLDKDGIFANSTSSKLLERAHGILTRNKNFKSKPALPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPSISAQFQASLSKLMETLGQAEPYFVKCIRSNAEKLPLRFSDVLVLRQLRYTGMLETVRIRQSGYSSKYSFQDFVSHFHVLLPRNIIPSKFNIQDFFRKINLNPDNYQVGKTMVFLKEQERQHLQDLLHQEVLRRIILLQRWFRVLLCRQHFLHLRQASVIIQRFWRNYLNQKQVRDAAVQKDAFVMASAAALLQASWRAHLERQRYLELRAAAIVIQQKWRDYYRRRHMAAICIQARWKAYRESKRYQEQRKKIILLQSTCRGFRARQRFKALKEQRLRETKPEVGLVNIKGYGSLEIQGSDPSGWEDCSFDNRIKAIEECKSVIESNRISRESSVDCLKESPNKQQERAQSQSGVDLQEDVLVRERPRSLEDLHQKKVGRAKRESRRMRELEQAIFSLELLKVRSLGGISPSEDRRWSTELVPEGLQSPRGTPDSESSQGSLELLSYEESQKSKLESVISDEGDLQFPSPKISSSPKFDSRDNALSASNETSSAEHLKDGTMKEMVVCSSESITCKPQLKDSFISNSLPTFFYIPQQDPLKTNSQLDTSIQRNKLLENEDTAGEALTLDINRETRRYHCSGKDQIVPSLNTESSNPVLKKLEKLNTEKEERQKQLQQQNEKEMMEQIRQQTDILEKERKAFKTIEKPRIGECLVAPSSYQSKQRVERPSSLLSLNTSNKGELNVLGSLSLKDAALAQKDSSSAHLPPKDRPVTVFFERKGSPCQSSTVKELSKTDRMGTQLNVACKLSNNRISKREHFRPTQSYSHNSDDLSREGNARPIFFTPKDNMSIPLVSKEALNSKNPQLHKEDEPAWKPVKLAGPGQRETSQRFSSVDEQAKLHKTMSQGEITKLAVRQKASDSDIRPQRAKMRFWAKGKQGEKKTTRVKPTTQSEVSPLFAGTDVIPAHQFPDELAAYHPTPPLSPELPGSCRKEFKENKEPSPKAKRKRSVKISNVALDSMHWQNDSVQIIASVSDLKSMDEFLLKKVNDLDNEDSKKDTLVDVVFKKALKEFRQNIFSFYSSALAMDDGKSIRYKDLYALFEQILEKTMRLEQRDSLGESPVRVWVNTFKVFLDEYMNEFKTSDCTATKVPKTERKKRRKKETDLVEEHNGHIFKATQYSIPTYCEYCSSLIWIMDRASVCKLCKYACHKKCCLKTTAKCSKKYDPELSSRQFGVELSRLTSEDRTVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCILRCPDTTDPLQSVQDISKTTTCVELIVVEQMNKYKARLKDISSLEFAENKAKTRLSLIRRSMGKGRIRRGNYPGPSSPVVVRLPSVSDVSEETLTSEAAMETDITEQQQAAMQQEERVLTEQIENLQKEKEELTFEMLVLEPRASDDETLESEASIGTADSSENLNMESEYAISEKSERSLALSSLKTAGKSEPSSKLRKQLKKQQDSLDVVDSSVSSLCLSNTASSHGTRKLFQIYSKSPFYRAASGNEALGMEGPLGQTKFLEDKPQFISRGTFNPEKGKQKLKNVKNSPQKTKETPEGTVMSGRRKTVDPDCTSNQQLALFGNNEFMV"},{"id":"SEQ_03661","a":"Q562F6","g":"SGO2","d":"Shugoshin 2","L":1265,"m":[{"c":"[HY]xψ[EK][KS][DGH][NS][LF][LF](x){1,2}[NT][QP][KE]DK[EV]xIx[EG]Nψ[DEQ][VD][TSP][NKS]E[FL][HEQ][TI][APV][NAD]L[SL][TI]+D[NS][GE]N[LQ][CY]D[YS]x[TI][QH]N[IV]L[DGE][LV][KQ][KH](x){5,6}[PS][SVA][EQC]QN-S[KN][IV][NG]K(x){1,2}Rx[KN]V[NC]xK[TS]EII[SP][EG]xN[HQ]ψ(x){0,2}[DN][ND][DN]K(x){2,4}","u":"97-100","sp":"tandem","x":"mixed","cf":"high","why":"Four contiguous head-to-tail 97-100 aa repeats spanning residues 541-933 with strong multi-block sequence conservation, anchored by invariant/near-invariant motifs including [NT][QP][KE]DK, ENψ...E[FL]...L[SL][TI]+, D[NS][GE]N[LQ][CY]D[YS]...N[IV]L, QN-S, K[TS]EII[SP], and a C-terminal [DN][ND][DN]K acidic cluster.","i":[[541,638,"HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVV"],[639,736,"HGLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIE"],[737,833,"YTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGV"],[834,933,"HDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHV"]]}],"s":"MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLITAIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLRDKMRR"},{"id":"SEQ_03665","a":"P22105","g":"TNXB","d":"Tenascin-X","L":4244,"m":[{"c":"xxxCPx[DGN]CxxxxxCxxGCψCxxGΩx[GS]x[DST]C[GSA]","u":31,"sp":"tandem","x":"structured_like","cf":"high","why":"18-copy tandem array of exact 31-aa cysteine-rich structured repeats (with a single 5-aa gap before copy 17) anchored by six invariant cysteines, invariant P5/G17/G24, conserved aliphatic ψ20, and aromatic Ω25.","i":[[184,214,"SGSCPDDCNDQGRCVRGRCVCFPGYTGPSCG"],[215,245,"WPSCPGDCQGRGRCVQGVCVCRAGFSGPDCS"],[246,276,"QRSCPRGCSQRGRCEGGRCVCDPGYTGDDCG"],[277,307,"MRSCPRGCSQRGRCENGRCVCNPGYTGEDCG"],[308,338,"VRSCPRGCSQRGRCKDGRCVCDPGYTGEDCG"],[339,369,"TRSCPWDCGEGGRCVDGRCVCWPGYTGEDCS"],[370,400,"TRTCPRDCRGRGRCEDGECICDTGYSGDDCG"],[401,431,"VRSCPGDCNQRGRCEDGRCVCWPGYTGTDCG"],[432,462,"SRACPRDCRGRGRCENGVCVCNAGYSGEDCG"],[463,493,"VRSCPGDCRGRGRCESGRCMCWPGYTGRDCG"],[494,524,"TRACPGDCRGRGRCVDGRCVCNPGFTGEDCG"],[525,555,"SRRCPGDCRGHGLCEDGVCVCDAGYSGEDCS"],[556,586,"TRSCPGGCRGRGQCLDGRCVCEDGYSGEDCG"],[587,617,"VRQCPNDCSQHGVCQDGVCICWEGYVSEDCS"],[618,648,"IRTCPSNCHGRGRCEEGRCLCDPGYTGPTCA"],[649,679,"TRMCPADCRGRGRCVQGVCLCHVGYGGEDCG"],[685,715,"ASACPGGCGPRELCRAGQCVCVEGFRGPDCA"],[716,746,"IQTCPGDCRGRGECHDGSCVCKDGYAGEDCG"]]},{"c":"[PDL](x){16,20}W(x){6,9}Ωxφ(x){31,41}Yxφxψx[GAS](x){16,19}","u":"85-97","sp":"dispersed","x":"structured_like","cf":"high","why":"32 structured ~85-97 aa beta-sandwich domain repeats separated by variable 0-33 aa linkers, anchored across all copies by an invariant W, downstream Ωxφ hydrophobic core, and C-terminal Yxφxψx[GAS] motif.","i":[[750,840,"PTIEGMRMHLLEETTVRTEWTPAPGPVDAYEIQFIPTTEGASPPFTARVPSSASAYDQRGLAPGQEYQVTVRALRGTSWGLPASKTITTMI"],[841,926,"DGPQDLRVVAVTPTTLELGWLRPQAEVDRFVVSYVSAGNQRVRLEVPPEADGTLLTDLMPGVEYVVTVTAERGRAVSYPASVRANT"],[960,1051,"PQELGELRVLGRDETGRLRVVWTAQPDTFAYFQLRMRVPEGPGAHEEVLPGDVRQALVPPPPPGTPYELSLHGVPPGGKPSDPIIYQGIMDK"],[1063,1150,"PRLGELTVTDRTSDSLLLRWTVPEGEFDSFVIQYKDRDGQPQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVGKKRHGPLVAEAKILP"],[1160,1247,"PHLGNLWVTDPTPDSLHLSWTVPEGQFDTFMVQYRDRDGRPQVVPVEGPERSFVVSSLDPDHKYRFTLFGIANKKRYGPLTADGTTAP"],[1262,1349,"PLLGELTVTGVTPDSLRLSWTVAQGPFDSFMVQYKDAQGQPQAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGRQRVGPESVVAKTAP"],[1373,1460,"PLLGELTVTGSSPDSLSLFWTVPQGSFDSFTVQYKDRDGRPRAVRVGGKESEVTVGGLEPGHKYKMHLYGLHEGQRVGPVSAVGVTAP"],[1475,1562,"PRLGELTVTDVTPNSVGLSWTVPEGQFDSFIVQYKDKDGQPQVVPVAADQREVTVYNLEPERKYKMNMYGLHDGQRMGPLSVVIVTAP"],[1578,1665,"PRLGELTVTDITPDSVGLSWTVPEGEFDSFVVQYKDRDGQPQVVPVAADQREVTIPDLEPSRKYKFLLFGIQDGKRRSPVSVEAKTVA"],[1675,1761,"PRLGELWVTDPTPDSLRLSWTVPEGQFDSFVVQFKDKDGPQVVPVEGHERSVTVTPLDAGRKYRFLLYGLLGKKRHGPLTADGTTEA"],[1776,1864,"PRLGEELQVTTVTQNSVGLSWTVPEGQFDSFVVQYKDRDGQPQVVPVEGSLREVSVPGLDPAHRYKLLLYGLHHGKRVGPISAVAITAG"],[1882,1969,"PHLGELTVEEATSHTLHLSWMVTEGEFDSFEIQYTDRDGQLQMVRIGGDRNDITLSGLESDHRYLVTLYGFSDGKHVGPVHVEALTVP"],[1988,2075,"PRLGELTVTDATPDSLSLSWTVPEGQFDHFLVQYRNGDGQPKAVRVPGHEEGVTISGLEPDHKYKMNLYGFHGGQRMGPVSVVGVTAA"],[2096,2183,"PLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVSAVGVTAP"],[2195,2282,"LRLGQMTVRDITSDSLSLSWTVPEGQFDHFLVQFKNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPVSAVGLTAP"],[2304,2391,"PRLEELTVTDATPDSLSLSWTVPEGQFDHFLVQYKNGDGQPKATRVPGHEDRVTISGLEPDNKYKMNLYGFHGGQRVGPVSAIGVTAA"],[2412,2499,"PLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVSTVGVTAP"],[2523,2609,"PLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGRPQAVRVGGQESKVTVRGLEPGRKYKMHLYGLHEGRRLGPVSAVGVTE"],[2629,2716,"PRLGELTMTDATPDSLSLSWTVPEGQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPISVIGVTAA"],[2737,2824,"PLLGELTVTGSSPDSLSLSWTIPQGHFDSFTVQYKDRDGRPQVMRVRGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVSTVGVTAP"],[2845,2932,"PRLGELTVTDATPDSLSLSWMVPEGQFDHFLVQYRNGDGQPKVVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPISVIGVTAA"],[2953,3040,"PLLGELTVTGSSPDSLSLSWTIPQGRFDSFTVQYKDRDGRPQVVRVRGEESEVTVGGLEPGCKYKMHLYGLHEGQRVGPVSAVGVTAP"],[3061,3147,"PRLGELTVTDATPDSLSLSWMVPEGQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPVSAIGVTE"],[3167,3254,"PLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGQPQVVRVRGEESEVTVGGLEPGRKYKMHLYGLHEGQRVGPVSTVGITAP"],[3263,3350,"PRLGELAVAAVTSDSVGLSWTVAQGPFDSFLVQYRDAQGQPQAVPVSGDLRAVAVSGLDPARKYKFLLFGLQNGKRHGPVPVEARTAP"],[3356,3443,"PRLGELTVTDATPDSVGLSWTVPEGEFDSFVVQYKDKDGRLQVVPVAANQREVTVQGLEPSRKYRFLLYGLSGRKRLGPISADSTTAP"],[3450,3537,"PHLGELTVAEETSSSLRLSWTVAQGPFDSFVVQYRDTDGQPRAVPVAADQRTVTVEDLEPGKKYKFLLYGLLGGKRLGPVSALGMTAP"],[3557,3644,"PRLGVLTVTDTTPDSMRLSWSVAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPYRFLLYGLHEGKRLGPLSAEGTTGL"],[3656,3752,"PRLSQLSVTDVTTSSLRLNWEAPPGAFDSFLLRFGVPSPSTLEPHPRPLLQRELMVPGTRHSAVLRDLRSGTLYSLTLYGLRGPHKADSIQGTARTL"],[3759,3845,"PRDLQFSEIRETSAKVNWMPPPSRADSFKVSYQLADGGEPQSVQVDGQARTQKLQGLIPGARYEVTVVSVRGFEESEPLTGFLTTVP"],[3848,3932,"PTQLRALNLTEGFAVLHWKPPQNPVDTYDVQVTAPGAPPLQAETPGSAVDYPLHDLVLHTNYTATVRGLRGPNLTSPASITFTTG"],[3936,4020,"PRDLEAKEVTPRTALLTWTEPPVRPAGYLLSFHTPGGQNQEILLPGGITSHQLLGLFPSTSYNARLQAMWGQSLLPPVSTSFTTG"]]},{"c":"-ETP[SA]PTE[PL][SG][TM]EAP[EG][PSA][PA]EE","u":19,"sp":"dispersed","x":"disordered_like","cf":"high","why":"7 highly conserved 19-aa acidic/proline-rich repeats located within non-overlapping disordered inter-domain linkers across the central repeat array, sharing 11 invariant E/T/P/A anchor positions.","i":[[1354,1372,"DETPSPTELGTEAPESPEE"],[2077,2095,"EETPSPTEPSMEAPEPAEE"],[2393,2411,"EETPSPTEPSMEAPEPPEE"],[2504,2522,"DETPSPTEPGTEAPGPPEE"],[2718,2736,"EETPSPTELSTEAPEPPEE"],[2934,2952,"EETPAPTEPSTEAPEPPEE"],[3148,3166,"EETPSPTEPSTEAPEAPEE"]]},{"c":"[PE][TP]xTPEPP[IN]K","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"5 dispersed 10-aa proline-rich linker motifs occurring in alternating disordered inter-domain linkers, anchored by an invariant TPEPP[IN]K C-terminal signature.","i":[[1978,1987,"PTATPEPPIK"],[2294,2303,"EPPTPEPPIK"],[2619,2628,"PTMTPEPPIK"],[2835,2844,"PTTTPEPPNK"],[3051,3060,"PTMTPEPPIK"]]}],"s":"MMPAQYALTSSLVLLVLLSTARAGPFSSRSNVTLPAPRPPPQPGGHTVGAGVGSPSSQLYEHTVEGGEKQVVFTHRINLPPSTGCGCPPGTEPPVLASEVQALRVRLEILEELVKGLKEQCTGGCCPASAQAGTGQTDVRTLCSLHGVFDLSRCTCSCEPGWGGPTCSDPTDAEIPPSSPPSASGSCPDDCNDQGRCVRGRCVCFPGYTGPSCGWPSCPGDCQGRGRCVQGVCVCRAGFSGPDCSQRSCPRGCSQRGRCEGGRCVCDPGYTGDDCGMRSCPRGCSQRGRCENGRCVCNPGYTGEDCGVRSCPRGCSQRGRCKDGRCVCDPGYTGEDCGTRSCPWDCGEGGRCVDGRCVCWPGYTGEDCSTRTCPRDCRGRGRCEDGECICDTGYSGDDCGVRSCPGDCNQRGRCEDGRCVCWPGYTGTDCGSRACPRDCRGRGRCENGVCVCNAGYSGEDCGVRSCPGDCRGRGRCESGRCMCWPGYTGRDCGTRACPGDCRGRGRCVDGRCVCNPGFTGEDCGSRRCPGDCRGHGLCEDGVCVCDAGYSGEDCSTRSCPGGCRGRGQCLDGRCVCEDGYSGEDCGVRQCPNDCSQHGVCQDGVCICWEGYVSEDCSIRTCPSNCHGRGRCEEGRCLCDPGYTGPTCATRMCPADCRGRGRCVQGVCLCHVGYGGEDCGQEEPPASACPGGCGPRELCRAGQCVCVEGFRGPDCAIQTCPGDCRGRGECHDGSCVCKDGYAGEDCGEEVPTIEGMRMHLLEETTVRTEWTPAPGPVDAYEIQFIPTTEGASPPFTARVPSSASAYDQRGLAPGQEYQVTVRALRGTSWGLPASKTITTMIDGPQDLRVVAVTPTTLELGWLRPQAEVDRFVVSYVSAGNQRVRLEVPPEADGTLLTDLMPGVEYVVTVTAERGRAVSYPASVRANTGSSPLGLLGTTDEPPPSGPSTTQGAQAPLLQQRPQELGELRVLGRDETGRLRVVWTAQPDTFAYFQLRMRVPEGPGAHEEVLPGDVRQALVPPPPPGTPYELSLHGVPPGGKPSDPIIYQGIMDKDEEKPGKSSGPPRLGELTVTDRTSDSLLLRWTVPEGEFDSFVIQYKDRDGQPQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVGKKRHGPLVAEAKILPQSDPSPGTPPHLGNLWVTDPTPDSLHLSWTVPEGQFDTFMVQYRDRDGRPQVVPVEGPERSFVVSSLDPDHKYRFTLFGIANKKRYGPLTADGTTAPERKEEPPRPEFLEQPLLGELTVTGVTPDSLRLSWTVAQGPFDSFMVQYKDAQGQPQAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGRQRVGPESVVAKTAPQEDVDETPSPTELGTEAPESPEEPLLGELTVTGSSPDSLSLFWTVPQGSFDSFTVQYKDRDGRPRAVRVGGKESEVTVGGLEPGHKYKMHLYGLHEGQRVGPVSAVGVTAPQQEETPPATESPLEPRLGELTVTDVTPNSVGLSWTVPEGQFDSFIVQYKDKDGQPQVVPVAADQREVTVYNLEPERKYKMNMYGLHDGQRMGPLSVVIVTAPLPPAPATEASKPPLEPRLGELTVTDITPDSVGLSWTVPEGEFDSFVVQYKDRDGQPQVVPVAADQREVTIPDLEPSRKYKFLLFGIQDGKRRSPVSVEAKTVARGDASPGAPPRLGELWVTDPTPDSLRLSWTVPEGQFDSFVVQFKDKDGPQVVPVEGHERSVTVTPLDAGRKYRFLLYGLLGKKRHGPLTADGTTEARSAMDDTGTKRPPKPRLGEELQVTTVTQNSVGLSWTVPEGQFDSFVVQYKDRDGQPQVVPVEGSLREVSVPGLDPAHRYKLLLYGLHHGKRVGPISAVAITAGREETETETTAPTPPAPEPHLGELTVEEATSHTLHLSWMVTEGEFDSFEIQYTDRDGQLQMVRIGGDRNDITLSGLESDHRYLVTLYGFSDGKHVGPVHVEALTVPEEEKPSEPPTATPEPPIKPRLGELTVTDATPDSLSLSWTVPEGQFDHFLVQYRNGDGQPKAVRVPGHEEGVTISGLEPDHKYKMNLYGFHGGQRMGPVSVVGVTAAEEETPSPTEPSMEAPEPAEEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVSAVGVTAPEEESPDAPLAKLRLGQMTVRDITSDSLSLSWTVPEGQFDHFLVQFKNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPVSAVGLTAPGKDEEMAPASTEPPTPEPPIKPRLEELTVTDATPDSLSLSWTVPEGQFDHFLVQYKNGDGQPKATRVPGHEDRVTISGLEPDNKYKMNLYGFHGGQRVGPVSAIGVTAAEEETPSPTEPSMEAPEPPEEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVSTVGVTAPQEDVDETPSPTEPGTEAPGPPEEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGRPQAVRVGGQESKVTVRGLEPGRKYKMHLYGLHEGRRLGPVSAVGVTEDEAETTQAVPTMTPEPPIKPRLGELTMTDATPDSLSLSWTVPEGQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPISVIGVTAAEEETPSPTELSTEAPEPPEEPLLGELTVTGSSPDSLSLSWTIPQGHFDSFTVQYKDRDGRPQVMRVRGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVSTVGVTAPEDEAETTQAVPTTTPEPPNKPRLGELTVTDATPDSLSLSWMVPEGQFDHFLVQYRNGDGQPKVVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPISVIGVTAAEEETPAPTEPSTEAPEPPEEPLLGELTVTGSSPDSLSLSWTIPQGRFDSFTVQYKDRDGRPQVVRVRGEESEVTVGGLEPGCKYKMHLYGLHEGQRVGPVSAVGVTAPKDEAETTQAVPTMTPEPPIKPRLGELTVTDATPDSLSLSWMVPEGQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPVSAIGVTEEETPSPTEPSTEAPEAPEEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGQPQVVRVRGEESEVTVGGLEPGRKYKMHLYGLHEGQRVGPVSTVGITAPLPTPLPVEPRLGELAVAAVTSDSVGLSWTVAQGPFDSFLVQYRDAQGQPQAVPVSGDLRAVAVSGLDPARKYKFLLFGLQNGKRHGPVPVEARTAPDTKPSPRLGELTVTDATPDSVGLSWTVPEGEFDSFVVQYKDKDGRLQVVPVAANQREVTVQGLEPSRKYRFLLYGLSGRKRLGPISADSTTAPLEKELPPHLGELTVAEETSSSLRLSWTVAQGPFDSFVVQYRDTDGQPRAVPVAADQRTVTVEDLEPGKKYKFLLYGLLGGKRLGPVSALGMTAPEEDTPAPELAPEAPEPPEEPRLGVLTVTDTTPDSMRLSWSVAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPYRFLLYGLHEGKRLGPLSAEGTTGLAPAGQTSEESRPRLSQLSVTDVTTSSLRLNWEAPPGAFDSFLLRFGVPSPSTLEPHPRPLLQRELMVPGTRHSAVLRDLRSGTLYSLTLYGLRGPHKADSIQGTARTLSPVLESPRDLQFSEIRETSAKVNWMPPPSRADSFKVSYQLADGGEPQSVQVDGQARTQKLQGLIPGARYEVTVVSVRGFEESEPLTGFLTTVPDGPTQLRALNLTEGFAVLHWKPPQNPVDTYDVQVTAPGAPPLQAETPGSAVDYPLHDLVLHTNYTATVRGLRGPNLTSPASITFTTGLEAPRDLEAKEVTPRTALLTWTEPPVRPAGYLLSFHTPGGQNQEILLPGGITSHQLLGLFPSTSYNARLQAMWGQSLLPPVSTSFTTGGLRIPFPRDCGEEMQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSMRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG"},{"id":"SEQ_03669","a":"O75074","g":"LRP3","d":"Low-density lipoprotein receptor-related protein 3","L":770,"m":[{"c":"CxxxxxxC(x){4,15}Cφxxxx[RQ]C[DN][GTN]xxxCx[DS]GxDEx[GN]C","u":"35-46","sp":"dispersed","x":"structured_like","cf":"high","why":"Five 6-cysteine structured repeats organized into two clusters (two copies at 166-249 and three closely spaced copies at 369-490), each displaying invariant disulfide-bonding cysteines, fixed inter-cysteine loop lengths outside the variable C2-C3 loop, a conserved hydrophobic-to-basic C3-C4 segment, and a signature acidic GxDE motif before C6.","i":[[166,200,"CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNC"],[212,249,"CPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGC"],[368,413,"CLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGC"],[416,452,"CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNC"],[455,489,"CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC"]]}],"s":"MEKRAAAGLEGAPGARAQLAVVCLVNIFLTGRLSSAVPALAACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAALIGSLVCGLLLVIALGCAFKLYSLRTQEYRAFETQMTRLEAEFVRREAPPSYGQLIAQGLIPPVEDFPVYSASQASVLQNLRTAMRRQMRRHASRRGPSRRRLGRLWNRLFHRPRAPRGQIPLLTAARPSQTVLGDGFLQPAPGAAPDPPAPLMDTGSTRAAGDRPPSAPGRAPEVGPSGPPLPSGLRDPECRPVDKDRKVCREPLVDGPAPADAPREPCSAQDPHPQVSTASSTLGPHSPEPLGVCRNPPPPCSPMLEASDDEALLVC"},{"id":"SEQ_03692","a":"O00515","g":"LAD1","d":"Ladinin-1","L":517,"m":[{"c":"φx[ED]Kxx","u":6,"sp":"tandem","x":"disordered_like","cf":"high","why":"Fourteen tandem 6-aa repeats (interrupted only by brief 5-aa and 12-aa linkers) within the central polar/charged disordered region, anchored by an invariant [ED]K dyad at positions 3-4, a conserved aliphatic/hydrophobic residue (V/A/I/L) at position 1 in 13 of 14 copies, and strong serine enrichment at position 2 (9/14).","i":[[173,178,"VPEKSP"],[179,184,"VLEKSS"],[190,195,"APEKSL"],[196,201,"VSDKTS"],[202,207,"ISEKVL"],[208,213,"ASEKTS"],[214,219,"LSEKIA"],[220,225,"VSEKRN"],[226,231,"SSEKKS"],[232,237,"VLEKTS"],[238,243,"VSEKSL"],[256,261,"VSEKAS"],[262,267,"IFEKAL"],[268,273,"ASEKSP"]]}],"s":"MAVSRKDWSALSSLARQRTLEDEEEQERERRRRHRNLSSTTDDEAPRLSQNGDRQASASERLPSVEEAEVPKPLPPASKDEDEDIQSILRTRQERRQRRQVVEAAQAPIQERLEAEEGRNSLSPVQATQKPLVSKKELEIPPRRRLSREQRGPWALEEESLVGREPEERKKGVPEKSPVLEKSSMPKKTAPEKSLVSDKTSISEKVLASEKTSLSEKIAVSEKRNSSEKKSVLEKTSVSEKSLAPGMALGSGRRLVSEKASIFEKALASEKSPTADAKPAPKRATASEQPLAQEPPASGGSPATTKEQRGRALPGKNLPSLAKQGASDPPTVASRLPPVTLQVKIPSKEEEADMSSPTQRTYSSSLKRSSPRTISFRMKPKKENSETTLTRSASMKLPDNTVKLGEKLERYHTAIRRSESVKSRGLPCTELFVAPVGVASKRHLFEKELAGQSRAEPASSRKENLRLSGVVTSRLNLWISRTQESGDQDPQEAQKASSATERTQWGQKSDSSLDAEV"},{"id":"SEQ_03707","a":"P24928","g":"POLR2A","d":"DNA-directed RNA polymerase II subunit RPB1","L":1970,"m":[{"c":"Y[STE][PL]x[ST]Px","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Massive 52-copy C-terminal tandem heptad array (residues 1593-1960) anchored by invariant Y1, nearly invariant P3/P6, and S/T-enriched positions 2, 4, and 5, with a canonical YSPTSPS N-terminal half transitioning to K/T/N-substituted position-7 variants in the C-terminal half.","i":[[1593,1599,"YSPTSPA"],[1600,1606,"YEPRSPG"],[1608,1614,"YTPQSPS"],[1615,1621,"YSPTSPS"],[1622,1628,"YSPTSPS"],[1629,1635,"YSPTSPN"],[1636,1642,"YSPTSPS"],[1643,1649,"YSPTSPS"],[1650,1656,"YSPTSPS"],[1657,1663,"YSPTSPS"],[1664,1670,"YSPTSPS"],[1671,1677,"YSPTSPS"],[1678,1684,"YSPTSPS"],[1685,1691,"YSPTSPS"],[1692,1698,"YSPTSPS"],[1699,1705,"YSPTSPS"],[1706,1712,"YSPTSPS"],[1713,1719,"YSPTSPS"],[1720,1726,"YSPTSPS"],[1727,1733,"YSPTSPS"],[1734,1740,"YSPTSPS"],[1741,1747,"YSPTSPN"],[1748,1754,"YSPTSPN"],[1755,1761,"YTPTSPS"],[1762,1768,"YSPTSPS"],[1769,1775,"YSPTSPN"],[1776,1782,"YTPTSPN"],[1783,1789,"YSPTSPS"],[1790,1796,"YSPTSPS"],[1797,1803,"YSPTSPS"],[1804,1810,"YSPSSPR"],[1811,1817,"YTPQSPT"],[1818,1824,"YTPSSPS"],[1825,1831,"YSPSSPS"],[1832,1838,"YSPTSPK"],[1839,1845,"YTPTSPS"],[1846,1852,"YSPSSPE"],[1853,1859,"YTPTSPK"],[1860,1866,"YSPTSPK"],[1867,1873,"YSPTSPK"],[1874,1880,"YSPTSPT"],[1881,1887,"YSPTTPK"],[1888,1894,"YSPTSPT"],[1895,1901,"YSPTSPV"],[1902,1908,"YTPTSPK"],[1909,1915,"YSPTSPT"],[1916,1922,"YSPTSPK"],[1923,1929,"YSPTSPT"],[1930,1936,"YSPTSPK"],[1940,1946,"YSPTSPG"],[1947,1953,"YSPTSPT"],[1954,1960,"YSLTSPA"]]},{"c":"[AG][WF]SP[ST]x[GA]S","u":8,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 8-residue copies in the Pro/Ser/Gly-rich disordered linker (residues 1530-1571) immediately preceding the tandem heptad array, anchored by a conserved W/F-S-P-[ST] core and C-terminal [GA]S.","i":[[1530,1537,"AWSPSVGS"],[1545,1552,"GFSPSAAS"],[1564,1571,"AWSPTPGS"]]}],"s":"MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDPRQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKGHGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEPRYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMPDFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIRIMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTGMFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPGYSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN"},{"id":"SEQ_03708","a":"Q9NV92","g":"NDFIP2","d":"NEDD4 family-interacting protein 2","L":336,"m":[{"c":"[LP]P[PT]Y[SD]xφ","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three clustered copies in the N-terminal proline/serine/threonine-rich disordered region preceding the transmembrane helices, anchored by invariant P2 and Y4 positions ([LP]P[PT]Y core), a conserved [SD] at +1, and an aliphatic hydrophobic residue (I/A) at +3.","i":[[148,154,"PPPYSSI"],[174,180,"PPPYSVA"],[183,189,"LPTYDEA"]]}],"s":"MARRRSQRVCASGPSMLNSARGAPELLRGTATNAEVSAAAAGATGSEELPPGDRGCRNGGGRGPAATTSSTGVAVGAEHGEDSLSRKPDPEPGRMDHHQPGTGRYQVLLNEEDNSESSAIEQPPTSNPAPQIVQAASSAPALETDSSPPPYSSITVEVPTTSDTEVYGEFYPVPPPYSVATSLPTYDEAEKAKAAAMAAAAAETSQRIQEEECPPRDDFSDADQLRVGNDGIFMLAFFMAFIFNWLGFCLSFCITNTIAGRYGAICGFGLSLIKWILIVRFSDYFTGYFNGQYWLWWIFLVLGLLLFFRGFVNYLKVRNMSESMAAAHRTRYFFLL"},{"id":"SEQ_03709","a":"Q5SW79","g":"CEP170","d":"Centrosomal protein of 170 kDa","L":1584,"m":[{"c":"[GA][ST][FY]TIE","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed occurrences across the central disordered region sharing an invariant TIE tripeptide preceded by a rare aromatic anchor ([FY]), a hydroxyl position ([ST]), and a small [GA] residue.","i":[[278,283,"ASFTIE"],[500,505,"GTYTIE"],[837,842,"GSFTIE"]]}],"s":"MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFGYDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQPSWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSSHITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSDVPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVTSSAHHRGGHGVPHGKLLKQKSEEPSVSIPFLQTALLRSSGSLGHRPSQEMDKMLKNQATSATSEKDNDDDQSDKGTYTIELENPNSEEVEARKMIDKVFGVDDNQDYNRPVINEKHKDLIKDWALSSAAAVMEERKPLTTSGFHHSEEGTSSSGSKRWVSQWASLAANHTRHDQEERIMEFSAPLPLENETEISESGMTVRSTGSATSLASQGERRRRTLPQLPNEEKSLESHRAKVVTQRSEIGEKQDTELQEKETPTQVYQKDKQDADRPLSKMNRAVNGETLKTGGDNKTLLHLGSSAPGKEKSETDKETSLVKQTLAKLQQQEQREEAQWTPTKLSSKNVSGQTDKCREETFKQESQPPEKNSGHSTSKGDRVAQSESKRRKAEEILKSQTPKGGDKKESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSSTPSSLALTSASRIRERSESLDPDSSMDTTLILKDTEAVMAFLEAKLREDNKTDEGPDTPSYNRDNSISPESDVDTASTISLVTGETERKSTQKRKSFTSLYKDRCSTGSPSKDVTKSSSSGAREKMEKKTKSRSTDVGSRADGRKFVQSSGRIRQPSVDLTDDDQTSSVPHSAISDIMSSDQETYSCKPHGRTPLTSADEHVHSKLEGSKVTKSKTSPVVSGSSSKSTTLPRPRPTRTSLLRRARLGEASDSELADADKASVASEVSTTSSTSKPPTGRRNISRIDLLAQPRRTRLGSLSARSDSEATISRSSASSRTAEAIIRSGARLVPSDKFSPRIRANSISRLSDSKVKSMTSAHGSASVNSRWRRFPTDYASTSEDEFGSNRNSPKHTRLRTSPALKTTRLQSAGSAMPTSSSFKHRIKEQEDYIRDWTAHREEIARISQDLALIAREINDVAGEIDSVTSSGTAPSTTVSTAATTPGSAIDTREELVDRVFDESLNFRKIPPLVHSKTPEGNNGRSGDPRPQAAEPPDHLTITRRRTWSRDEVMGDNLLLSSVFQFSKKIRQSIDKTAGKIRILFKDKDRNWDDIESKLRAESEVPIVKTSSMEISSILQELKRVEKQLQAINAMIDPDGTLEALNNMGFPSAMLPSPPKQKSSPVNNHHSPGQTPTLGQPEARALHPAAVSAAAEFENAESEADFSIHFNRFNPDGEEEDVTVQE"},{"id":"SEQ_03713","a":"O14990","g":"PPP1R2C","d":"Protein phosphatase inhibitor 2 family member C","L":202,"m":[{"c":"SV[QR][DG][NV][GE][EG][DEK]","u":8,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three tandem copies in an acidic/polar disordered segment anchored by an invariant N-terminal SV dipeptide, polar/basic [QR], and G/E-rich C-terminal positions (copy 1 is an 8-mer head-to-tail with two 9-mer units SVRDVEGED and SVRGVEGKE, leaving a 1-aa D gap between copies 2 and 3).","i":[[77,84,"SVQDNGED"],[85,92,"SVRDVEGE"],[94,101,"SVRGVEGK"]]}],"s":"MSASTSSHRPIKGILKNKSSSGSSVATSGQQSGGTIQDVKRKKSQKWDESSILAAHRATYRDYDLMKANEPGTSYMSVQDNGEDSVRDVEGEDSVRGVEGKEATDASDHSCEVDEQESSEAYMRKILLHKQEKKRQFEMRRRLHYNEELNIKLARQLMWKELQSEDNENEETPQGTNEEKTAAEESEEAPLTGGLQTQSCDP"},{"id":"SEQ_03724","a":"Q96JN0","g":"LCOR","d":"Ligand-dependent corepressor","L":433,"m":[{"c":"[SGR][PVG]ψDL[STK]","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed copies arranged in two pairs within disordered regions, anchored by an invariant DL dipeptide preceded by [PVG] and a large aliphatic residue (ψ) and followed by [STK]; the first two copies also share broader 13-residue flanking homology (DQDSPLDLTVRKS vs EQDGVLDLSTKKS).","i":[[63,68,"SPLDLT"],[81,86,"GVLDLS"],[249,254,"SPVDLK"],[259,264,"RGMDLS"]]}],"s":"MQRMIQQFAAEYTSKNSSTQDPSQPNSTKNQSLPKASPVTTSPTAATTQNPVLSKLLMADQDSPLDLTVRKSQSEPSEQDGVLDLSTKKSPCAGSTSLSHSPGCSSTQGNGRPGRPSQYRPDGLRSGDGVPPRSLQDGTREGFGHSTSLKVPLARSLQISEELLSRNQLSTAASLGPSGLQNHGQHLILSREASWAKPHYEFNLSRMKFRGNGALSNISDLPFLAENSAFPKMALQAKQDGKKDVSHSSPVDLKIPQVRGMDLSWESRTGDQYSYSSLVMGSQTESALSKKLRAILPKQSRKSMLDAGPDSWGSDAEQSTSGQPYPTSDQEGDPGSKQPRKKRGRYRQYNSEILEEAISVVMSGKMSVSKAQSIYGIPHSTLEYKVKERLGTLKNPPKKKMKLMRSEGPDVSVKIELDPQGEAAQSANESKNE"},{"id":"SEQ_03730","a":"Q6UXH8","g":"CCBE1","d":"Collagen and calcium-binding EGF domain-containing protein 1","L":406,"m":[{"c":"DφD[VE]CA(x){3,6}CxxxCx[DN]oφGxφxCxCxxGYxx-x-(x){2,8}[YT]C","u":"41-44","sp":"tandem","x":"structured_like","cf":"high","why":"Two head-to-tail tandem 41-44 aa cysteine-rich domains (separated by 1 residue) sharing six identically spaced cysteines, a conserved N-terminal DφD[VE]CA motif, an internal oφGxφ loop, and a CxCxxGYxx-x- core.","i":[[89,132,"DYDVCAEAPCEQQCTDNFGRVLCTCYPGYRYDRERHRKREKPYC"],[134,174,"DIDECASSNGTLCAHICINTLGSYRCECREGYIREDDGKTC"]]}],"s":"MVPPPPSRGGAARGQLGRSLGPLLLLLALGHTWTYREEPEDGDREICSESKIATTKYPCLKSSGELTTCYRKKCCKGYKFVLGQCIPEDYDVCAEAPCEQQCTDNFGRVLCTCYPGYRYDRERHRKREKPYCLDIDECASSNGTLCAHICINTLGSYRCECREGYIREDDGKTCTRGDKYPNDTGHEKSENMVKAGTCCATCKEFYQMKQTVLQLKQKIALLPNNAADLGKYITGDKVLASNTYLPGPPGLPGGQGPPGSPGPKGSPGFPGMPGPPGQPGPRGSMGPMGPSPDLSHIKQGRRGPVGPPGAPGRDGSKGERGAPGPRGSPGPPGSFDFLLLMLADIRNDITELQEKVFGHRTHSSAEEFPLPQEFPSYPEAMDLGSGDDHPRRTETRDLRAPRDFYP"},{"id":"SEQ_03734","a":"P37275","g":"ZEB1","d":"Zinc finger E-box-binding homeobox 1","L":1124,"m":[{"c":"CxxCxxx[FY]xxxx[SQH][LY]xxH(x){2,5}[HC]","u":"20-23","sp":"dispersed","x":"structured_like","cf":"high","why":"Seven C2H2/C2HC-type zinc-coordinating repeats split into an N-terminal cluster of four and a C-terminal cluster of three, anchored by invariant CxxC and Hxxx[HC] coordination motifs plus conserved aromatic ([FY]) and hydrophobic ([LY]) core positions.","i":[[172,193,"CPYCDRGYKRFTSLKEHIKYRH"],[202,222,"CSLCSYTFAYRTQLERHMTSH"],[242,262,"CTECGKAFKYKHHLKEHLRIH"],[270,292,"CPNCKKRFSHSGSYSSHISSKKC"],[906,926,"CDLCDKIFQKSSSLLRHKYEH"],[934,954,"CGICKKAFKHKHHLIEHMRLH"],[962,981,"CDKCGKRFSHSGSYSQHMNH"]]},{"c":"[SE]PL[DN]LS","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three closely spaced copies within the central disordered region (positions 705-771) sharing four invariant anchor positions (xPLxLS) and constrained two-residue choices ([SE] and [DN]), with the latter two copies also preceded by QEEP.","i":[[706,711,"SPLNLS"],[733,738,"EPLDLS"],[766,771,"EPLNLS"]]}],"s":"MADGPRCKRRKQANPRRNNVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDDLPTDQTVLPGRSSEREGNAKNCWEDDRKEGQEILGPEAQADEAGCTVKDDECESDAENEQNHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDENGTPDAFSQLLTCPYCDRGYKRFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVNGRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVVASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGDINALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNNDQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYLYTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTENGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA"},{"id":"SEQ_03736","a":"Q9Y5I4","g":"PCDHAC2","d":"Protocadherin alpha-C2","L":1007,"m":[{"c":"(x){12,18}P[GAN]xxφxxxxxxDxDxxxNxxφxYxL(x){20,27}φD[RY]ExxxxxxφxVxAxDxGxPxxxxxxxφxVxVxDxNDNxPxφ","u":"104-111","sp":"tandem","x":"structured_like","cf":"high","why":"Six contiguous head-to-tail structured repeats of 104-111 aa spanning positions 42-688, anchored by N-terminal P[GAN]xxφ and DxDxxxNxxφxYxL motifs, a central φD[RY]E motif, and C-terminal φxVxAxDxGxP and φxVxVxDxNDNxPxφ beta-strand/loop signatures (with the sixth copy diverging only at the C-terminal DxNDN motif).","i":[[42,148,"SQLRYSVPEEQAPGALVGNVARALGLELRRLGPGCLRINHLGAPSPRYLELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAVSAVEVEILDINDNSPRF"],[149,257,"PRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAF"],[258,365,"DQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEV"],[366,469,"VLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATLPFRLNGFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPPSF"],[470,580,"LEDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHIL"],[581,688,"YPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAITVAVVDRVSKIL"]]}],"s":"MEQAGTRPAATEHPRLRRPMPWLLLLPLLLLLLLLLPGPAASQLRYSVPEEQAPGALVGNVARALGLELRRLGPGCLRINHLGAPSPRYLELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAVSAVEVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATLPFRLNGFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSASVAITVAVVDRVSKILPDTQRHVKSPRTYSEITLYLIIALSTVSFIFLLTIIILSIIKCYRYTAYGTACCGGFCGVRERSPAELYKQANNNIDARIPHGLKVQPHFIEVRGNGSLTKTYCYKACLTAGSGSDTFMFYNTGAQTGPGPSGAQAAVTDSRNLTGQSGQNAGNLIILKNEAVSQNEPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ"},{"id":"SEQ_03742","a":"O43189","g":"PHF1","d":"PHD finger protein 1","L":567,"m":[{"c":"CφC(x){12,13}C[ER][KS]CxxxΩH[QE][DA]C(x){17,18}CxxC","u":49,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two 49-aa structured repeats separated by a 49-aa linker, sharing eight strictly aligned cysteine/histidine positions (CφC, CxxCxxxΩHxxC, and CxxC) plus an invariant aromatic residue immediately preceding the conserved histidine.","i":[[91,139,"CVCRSETVVPGNRLVSCEKCRHAYHQDCHVPRAPAPGEGEGTSWVCRQC"],[189,237,"CYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVC"]]}],"s":"MAQPPRLSRSGASSLWDPASPAPTSGPRPRLWEGQDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLWKDISPAALPGEELLCCVCRSETVVPGNRLVSCEKCRHAYHQDCHVPRAPAPGEGEGTSWVCRQCVFAIATKRGGALKKGPYARAMLGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVCRGGPEKVRRLQLRWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGELSDTPKGERSSRLLSALNSHKDRFISGREIKKRKCLFGLHARMPPPVEPPTGDGALTSFPSGQGPGGGVSRPLGKRRRPEPEPLRRRQKGKVEELGPPSAVRNQPEPQEQRERAHLQRALQASVSPPSPSPNQSYQGSSGYNFRPTDARCLPSSPIRMFASFHPSASTAGTSGDSGPPDRSPLELHIGFPTDIPKSAPHSMTASSSSVSSPSPGLPRRSAPPSPLCRSLSPGTGGGVRGGVGYLSRGDPVRVLARRVRPDGSVQYLVEWGGGGIF"},{"id":"SEQ_03759","a":"A6NIX2","g":"WTIP","d":"Wilms tumor protein 1-interacting protein","L":430,"m":[{"c":"CxxC[GA]xxIφ(x){10,17}YHxxCΩ(x){1,4}CxxC(x){15,20}Cxx[DC]","u":"52-61","sp":"dispersed","x":"structured_like","cf":"high","why":"Three C-terminal zinc-binding repeats separated by short 8-12 aa linkers share a conserved dual-module ligand architecture (CxxC, YHxxCΩ, CxxC, and Cxx[DC]) plus an invariant isoleucine-hydrophobic pair (Iφ) following the N-terminal CxxC motif.","i":[[225,277,"CIKCGLGIYGAQQACQAMGSLYHTDCFTCDSCGRRLRGKAFYNVGEKVYCQED"],[290,341,"CSVCGHLIMEMILQALGKSYHPGCFRCSVCNECLDGVPFTVDVENNIYCVRD"],[350,410,"CASCARPILPAQGCETTIRVVSMDRDYHVACYHCEDCGLQLSGEEGRRCYPLAGHLLCRRC"]]}],"s":"MQRSRAGADEAALLLAGLALRELEPGCGSPGRGRRGPRPGPGDEAAPALGRRGKGSGGPEAGADGLSRGERGPRRAAVPELSAQPAGSPRASLAGSDGGGGGGSARSSGISLGYDQRHGSPRSGRSDPRPGPGPPSVGSARSSVSSLGSRGSAGAYADFLPPGACPAPARSPEPAGPAPFPLPALPLPPGREGGPSAAERRLEALTRELERALEARTARDYFGICIKCGLGIYGAQQACQAMGSLYHTDCFTCDSCGRRLRGKAFYNVGEKVYCQEDFLYSGFQQTADKCSVCGHLIMEMILQALGKSYHPGCFRCSVCNECLDGVPFTVDVENNIYCVRDYHTVFAPKCASCARPILPAQGCETTIRVVSMDRDYHVACYHCEDCGLQLSGEEGRRCYPLAGHLLCRRCHLRRLQPGPLPSPTVHVTEL"},{"id":"SEQ_03775","a":"Q9H1E5","g":"TMX4","d":"Thioredoxin-related transmembrane protein 4","L":349,"m":[{"c":"EE[EN]K-[DS][LS]x-","u":9,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three head-to-tail 9-aa repeats (0-1 aa gap) in the C-terminal acidic disordered tail anchored by invariant EE and internal K positions flanked by conserved acidic and polar/aliphatic ([DS][LS]) residues.","i":[[245,253,"EEEKDDSNE"],[254,262,"EENKDSLVD"],[264,272,"EEEKEDLGD"]]}],"s":"MAGGRCGPQLTALLAAWIAAVAATAGPEEAALPPEQSRVQPMTASNWTLVMEGEWMLKFYAPWCPSCQQTDSEWEAFAKNGEILQISVGKVDVIQEPGLSGRFFVTTLPAFFHAKDGIFRRYRGPGIFEDLQNYILEKKWQSVEPLTGWKSPASLTMSGMAGLFSISGKIWHLHNYFTVTLGIPAWCSYVFFVIATLVFGLFMGLVLVVISECFYVPLPRHLSERSEQNRRSEEAHRAEQLQDAEEEKDDSNEEENKDSLVDDEEEKEDLGDEDEAEEEEEEDNLAAGVDEERSEANDQGPPGEDGVTREEVEPEEAEEGISEQPCPADTEVVEDSLRQRKSQHADKGL"},{"id":"SEQ_03784","a":"P22681","g":"CBL","d":"E3 ubiquitin-protein ligase CBL","L":906,"m":[{"c":"P[LRK]PφP[KRP]","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed copies in the C-terminal proline-rich disordered region sharing an invariant PxPxP polyproline register with a conserved hydrophobic residue at position 4 and predominantly basic/aliphatic anchors at positions 2 and 6.","i":[[532,537,"PLPVPP"],[592,597,"PRPIPK"],[680,685,"PLPVPK"],[824,829,"PKPFPR"]]},{"c":"[LK]PPVP","u":5,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three non-overlapping dispersed 5-aa motifs in the C-terminal disordered region sharing an invariant PPVP core preceded by L or K in a distinct xPPVP proline register.","i":[[493,497,"LPPVP"],[578,582,"LPPVP"],[778,782,"KPPVP"]]}],"s":"MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGAPSPNYDDDDDERADDTLFMMKELAGAKVERPPSPFSMAPQASLPPVPPRLDLLPQRVCVPSSASALGTASKAASGSLHKDKPLPVPPTLRDLPPPPPPDRPYSVGAESRPQRRPLPCTPGDCPSRDKLPPVPSSRLGDSWLPRPIPKVPVSAPSSSDPWTGRELTNRHSLPFSLPSQMEPRPDVPRLGSTFSLDTSMSMNSSPLVGPECDHPKIKPSSSANAIYSLAARPLPVPKLPPGEQCEGEEDTEYMTPSSRPLRPLDTSQSSRACDCDQQIDSCTYEAMYNIQSQAPSITESSTFGEGNLAAAHANTGPEESENEDDGYDVPKPPVPAVLARRTLSDISNASSSFGWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSERKAGSCQQGSGPAASAATASPQLSSEIENLMSQGYSYQDIQKALVIAQNNIEMAKNILREFVSISSPAHVAT"},{"id":"SEQ_03788","a":"Q99460","g":"PSMD1","d":"26S proteasome non-ATPase regulatory subunit 1","L":953,"m":[{"c":"x(x){0,1}xx[GA]xφxφ[GA]φφφx[GA]xxxx(x){0,6}xxφxxφxxxxxx(x){0,2}[DN]xxψ","u":"34-42","sp":"tandem","x":"structured_like","cf":"high","why":"Head-to-tail tandem array of 9 helical bi-helical repeats (34-42 aa, with a 6-aa turn insertion in copy 8) anchored by N-terminal [GA] caps, a hydrophobic xφxφ[GA]φφφx core helix, a [GA]-initiated inter-helical turn, a second amphipathic segment, and a conserved C-terminal [DN]xxψ motif where the terminal aliphatic residue (V/I/L/M) is invariant across all 9 copies.","i":[[437,473,"YQEGGGLYALGLIHANHGGDIIDYLLNQLKNASNDIV"],[474,507,"RHGGSLGLGLAAMGTARQDVYDLLKTNLYQDDAV"],[508,544,"TGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKI"],[545,578,"LRGLAVGIALVMYGRMEEADALIESLCRDKDPIL"],[579,614,"RRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDV"],[615,648,"RRAAVESLGFILFRTPEQCPSVVSLLSESYNPHV"],[649,683,"RYGAAMALGICCAGTGNKEAINLLEPMTNDPVNYV"],[684,725,"RQGALIASALIMIQQTEITCPKVNQFRQLYSKVINDKHDDVM"],[726,761,"AKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVV"]]}],"s":"MITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASKVFYHLGAFEESLNYALGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVENADLPEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRLDVFEKTILESNDVPGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKEDNLLMAYQICFDLYESASQQFLSSVIQNLRTVGTPIASVPGSTNTGTVPGSEKDSDSMETEEKTSSAFVGKTPEASPEPKDQTLKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAVRNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEALQLMATYLPKDTSPGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASNDIVRHGGSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVMYGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPSVVSLLSESYNPHVRYGAAMALGICCAGTGNKEAINLLEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVNQFRQLYSKVINDKHDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLSLAYTPTCVIGLNKDLKMPKVQYKSNCKPSTFAYPAPLEVPKEKEKEKVSTAVLSITAKAKKKEKEKEKKEEEKMEVDEAEKKEEKEKKKEPEPNFQLLDNPARVMPAQLKVLTMPETCRYQPFKPLSIGGIIILKDTSEDIEELVEPVAAHGPKIEEEEQEPEPPEPFEYIDD"},{"id":"SEQ_03792","a":"Q7Z7B0","g":"FILIP1","d":"Filamin-A-interacting protein 1","L":1213,"m":[{"c":"L+D-LxKLKSF[AT]ψMLVDERxxxψE","u":24,"sp":"dispersed","x":"structured_like","cf":"high","why":"High-conservation 24-aa internal duplication separated by 233 residues within the central coiled-coil region, sharing 15/24 identical anchors (including the contiguous KLKSF[AT]ψMLVDER core) and 5 additional physicochemically conserved positions far above generic heptad background.","i":[[236,259,"LRDELVKLKSFALMLVDERQMHIE"],[494,517,"LKDDLTKLKSFTVMLVDERKNMME"]]}],"s":"MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQVGLKKPVERSSVLDRYPPAANELTMRKSWIPWMRKRENGPSITQEKGPRTNSSPGHPGEVVLSPKQGQPLHIRVTPDHENSTATLEITSPTSEEFFSSTTVIPTLGNQKPRITIIPSPNVMPQKQKSGDTTLGPERAMSPVTITTFSREKTPESGRGAFADRPTSPIQIMTVSTSAAPAEIAVSPESQEMPMGRTILKVTPEKQTVPTPVRKYNSNANIITTEDNKIHIHLGSQFKRSPGTSGEGVSPVITVRPVNVTAEKEVSTGTVLRSPRNHLSSRPGASKVTSTITITPVTTSSARGTQSVSGQDGSSQRPTPTRIPMSKGMKAGKPVVAAPGAGNLTKFEPRAETQSMKIELKKSAASSTTSLGGGKG"},{"id":"SEQ_03797","a":"Q9Y5X1","g":"SNX9","d":"Sorting nexin-9","L":595,"m":[{"c":"xxxWxx","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Cluster of five non-overlapping tryptophan-anchored hexamers (within a 67-residue disordered region containing seven W residues total, including closely spaced NDPWSAWSAS and DDDDWDEDWDG doublets) embedded in an aliphatic-depleted IDR. Every flanking position across all copies is strictly restricted to acidic, polar, or small turn/coil residues (D, E, N, S, T, G, A, P), with frequent acidic/amide caps preceding W and acidic or small hydroxyl/alanine residues following W.","i":[[105,110,"NDPWSA"],[116,121,"SGNWES"],[122,127,"SEGWGA"],[141,146,"PNNWDT"],[166,171,"DEDWDG"]]}],"s":"MATKARVMYDFAAEPGNNELTVNEGEIITITNPDVGGGWLEGRNIKGERGLVPTDYVEILPSDGKDQFSCGNSVADQAFLDSLSASTAQASSSAASNNHQVGSGNDPWSAWSASKSGNWESSEGWGAQPEGAGAQRNTNTPNNWDTAFGHPQAYQGPATGDDDDWDEDWDGPKSSSYFKDSESADAGGAQRGNSRASSSSMKIPLNKFPGFAKPGTEQYLLAKQLAKPKEKIPIIVGDYGPMWVYPTSTFDCVVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVISESEVFQQFLNFRDEKEWKTGKRKAERDELAGVMIFSTMEPEAPDLDLVEIEQKCEAVGKFTKAMDDGVKELLTVGQEHWKRCTGPLPKEYQKIGKALQSLATVFSSSGYQGETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLMECNHEYKGFLGCFPDIIGTHKGAIEKVKESDKLVATSKITLQDKQNMVKRVSIMSYALQAEMNHFHSNRIYDYNSVIRLYLEQQVQFYETIAEKLRQALSRFPVM"},{"id":"SEQ_03801","a":"Q6XZF7","g":"DNMBP","d":"Dynamin-binding protein","L":1577,"m":[{"c":"[AC]xxx[FL]xxxxxx[EDN][LV][PDS][LFV]xx[GN][DQ]xψxψxx(x){5,10}W[LF](x){7,9}Gx[FV][PY]xx[FCY]ψ","u":"48-52","sp":"dispersed","x":"structured_like","cf":"high","why":"Six dispersed ~48-52 aa globular repeats (four clustered in the N-terminal region and two near the C-terminus) anchored by an N-terminal [AC]xxx[FL] motif, an internal [EDN][LV][PDS][LFV]xx[GN][DQ]xψxψ segment, an invariant W[LF] core flanked by short variable loops, and a C-terminal Gx[FV][PY]xx[FCY]ψ signature.","i":[[9,56,"AIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFV"],[73,121,"CICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCV"],[152,199,"ALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFV"],[250,297,"ALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFV"],[1292,1343,"AERNFNAAQDLDVSLLEGDLVGVIKKKDPMGSQNRWLIDNGVTKGFVYSSFL"],[1520,1571,"AVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNYI"]]}],"s":"MEAGSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLKEGERLFVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLCPDTRVEETMALPQEGSLARIPETSLDCLENTLGVEEQRHETSDHEAEEPDCIISEAPTSPLGHLTSEYDTDRNSYQDEDTAGGPPRSPGVEWEMPLATDSPTSDPTEVVNGISSQPQVPFHPNLQKSQYYSTVGGSHPHSEQYPDLLPLEARTRDYASLPPKRMYSQLKTLQKPVLPLYRGSSVSASRVVKPRQSSPQLHNLASYTKKHHTSSVYSISERLEMKPGPQAQGLVMEAATHSQGDGSTDLDSKLTQQLIEFEKSLAGPGTEPDKILRHFSIMDFNSEKDIVRGSSKLITEQELPERRKALRPPPPRPCTPVSTSPHLLVDQNLKPAPPLVVRPSRPAPLPPSAQQRTNAVSPKLLSRHRPTCETLEKEGPGHMGRSLDQTSPCPLVLVRIEEMERDLDMYSRAQEELNLMLEEKQDESSRAETLEDLKFCESNIESLNMELQQLREMTLLSSQSSSLVAPSGSVSAENPEQRMLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNIDFEGLFGNMQMVIKVSKQLLAALEISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEINVNINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSNRVSSHLKHLTGFAPQIKDEVFEETEKNFRMQERLIKSFIRDLSLYLQHIRESACVKVVAAVSMWDVCMERGHRDLEQFERVHRYISDQLFTNFKERTERLVISPLNQLLSMFTGPHKLVQKRFDKLLDFYNCTERAEKLKDKKTLEELQSARNNYEALNAQLLDELPKFHQYAQGLFTNCVHGYAEAHCDFVHQALEQLKPLLSLLKVAGREGNLIAIFHEEHSRVLQQLQVFTFFPESLPATKKPFERKTIDRQSARKPLLGLPSYMLQSEELRASLLARYPPEKLFQAERNFNAAQDLDVSLLEGDLVGVIKKKDPMGSQNRWLIDNGVTKGFVYSSFLKPYNPRRSHSDASVGSHSSTESEHGSSSPRFPRQNSGSTLTFNPSSMAVSFTSGSCQKQPQDASPPPKECDQGTLSASLNPSNSESSPSRCPSDPDSTSQPRSGDSADVARDVKQPTATPRSYRNFRHPEIVGYSVPGRNGQSQDLVKGCARTAQAPEDRSTEPDGSEAEGNQVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNYIRKTEYT"},{"id":"SEQ_03803","a":"O43516","g":"WIPF1","d":"WAS/WASL-interacting protein family member 1","L":503,"m":[{"c":"[GP]RSGP[LR]PP[PL]P","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 10-residue motifs in the C-terminal proline/serine-rich disordered region anchored by an invariant RSGP core followed by [LR]PP[PL]P, including two identical GRSGPLPPPP copies.","i":[[352,361,"GRSGPLPPPP"],[374,383,"GRSGPLPPPP"],[410,419,"PRSGPRPPLP"]]},{"c":"PPVP[SG][TG]PR","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three non-overlapping dispersed 8-residue repeats in the central disordered region sharing six invariant anchor positions (PPVP..PR, with fixed aliphatic V and C-terminal basic R) and constrained [SG][TG] central residues, including two identical PPVPSTPR copies.","i":[[185,192,"PPVPSTPR"],[204,211,"PPVPGGPR"],[292,299,"PPVPSTPR"]]}],"s":"MPVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILDKPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPSKLARNESRSGSNRRERGAPPLPPIPR"},{"id":"SEQ_03832","a":"P13611","g":"VCAN","d":"Versican core protein","L":3396,"m":[{"c":"[VL]DGxVFH[YL](x){7,10}FE[AE]A[QA]K[AE]Cx[DN]xxAxψATxx[QE]LxAAΩx[DN]GF-QCDφGWL[AS]Dx[TS]VR[YH]Pψxφ[PA]RφxC(x){5,8}GVRT(x){9,16}ΩDφYCΩ","u":"98-99","sp":"tandem","x":"structured_like","cf":"high","why":"Two adjacent 98-99 aa globular repeats in the N-terminal region separated by a 3-aa linker (VDH), sharing four invariant cysteines, conserved aromatic/hydrophobic cores ([VL]DGxVFH[YL], FE[AE]A[QA]K[AE]C, AxψAT, [QE]LxAAΩx[DN]GF-QCDφGWL, GVRT, and ΩDφYCΩ), and minor internal loop length shifts.","i":[[147,244,"VDGVVFHYRAATSRYTLNFEAAQKACLDVGAVIATPEQLFAAYEDGFEQCDAGWLADQTVRYPIRAPRVGCYGDKMGKAGVRTYGFRSPQETYDVYCY"],[248,346,"LDGDVFHLTVPSKFTFEEAAKECENQDARLATVGELQAAWRNGFDQCDYGWLSDASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCF"]]},{"c":"D[RE]C[KH]xNPCxNG[GA]TCφxxxo[ST]ΩxCxCψP[GS]YxGxxCE","u":35,"sp":"tandem","x":"structured_like","cf":"high","why":"Two adjacent 35-aa cysteine-rich repeats in the C-terminal region separated by a 3-aa linker (LDF), conserving six invariant cysteines with identical spacing plus fixed D, N, P, N, G, T, P, Y, G, and E anchors (16/35 identical positions).","i":[[3091,3125,"DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCE"],[3129,3163,"DECHSNPCRNGATCVDGFNTFRCLCLPSYVGALCE"]]},{"c":"[EQ]GSG[ED]","u":5,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Five dispersed 5-aa occurrences within the central S/T/E/P-rich disordered region (residues 1646-2439) featuring an invariant GSG core symmetrically flanked by acidic/polar [EQ] and [ED] residues in an otherwise G-depleted (~5% G) context.","i":[[1640,1644,"EGSGE"],[1835,1839,"QGSGE"],[1957,1961,"EGSGD"],[2009,2013,"EGSGE"],[2431,2435,"EGSGE"]]}],"s":"MFINIKSILWMCSTLIVTHALHKVKVGKSPPVRGSLSGKVSLPCHFSTMPTLPPSYNTSEFLRIKWSKIEVDKNGKDLKETTVLVAQNGNIKIGQDYKGRVSVPTHPEAVGDASLTVVKLLASDAGLYRCDVMYGIEDTQDTVSLTVDGVVFHYRAATSRYTLNFEAAQKACLDVGAVIATPEQLFAAYEDGFEQCDAGWLADQTVRYPIRAPRVGCYGDKMGKAGVRTYGFRSPQETYDVYCYVDHLDGDVFHLTVPSKFTFEEAAKECENQDARLATVGELQAAWRNGFDQCDYGWLSDASVRHPVTVARAQCGGGLLGVRTLYRFENQTGFPPPDSRFDAYCFKPKEATTIDLSILAETASPSLSKEPQMVSDRTTPIIPLVDELPVIPTEFPPVGNIVSFEQKATVQPQAITDSLATKLPTPTGSTKKPWDMDDYSPSASGPLGKLDISEIKEEVLQSTTGVSHYATDSWDGVVEDKQTQESVTQIEQIEVGPLVTSMEILKHIPSKEFPVTETPLVTARMILESKTEKKMVSTVSELVTTGHYGFTLGEEDDEDRTLTVGSDESTLIFDQIPEVITVSKTSEDTIHTHLEDLESVSASTTVSPLIMPDNNGSSMDDWEERQTSGRITEEFLGKYLSTTPFPSQHRTEIELFPYSGDKILVEGISTVIYPSLQTEMTHRRERTETLIPEMRTDTYTDEIQEEITKSPFMGKTEEEVFSGMKLSTSLSEPIHVTESSVEMTKSFDFPTLITKLSAEPTEVRDMEEDFTATPGTTKYDENITTVLLAHGTLSVEAATVSKWSWDEDNTTSKPLESTEPSASSKLPPALLTTVGMNGKDKDIPSFTEDGADEFTLIPDSTQKQLEEVTDEDIAAHGKFTIRFQPTTSTGIAEKSTLRDSTTEEKVPPITSTEGQVYATMEGSALGEVEDVDLSKPVSTVPQFAHTSEVEGLAFVSYSSTQEPTTYVDSSHTIPLSVIPKTDWGVLVPSVPSEDEVLGEPSQDILVIDQTRLEATISPETMRTTKITEGTTQEEFPWKEQTAEKPVPALSSTAWTPKEAVTPLDEQEGDGSAYTVSEDELLTGSERVPVLETTPVGKIDHSVSYPPGAVTEHKVKTDEVVTLTPRIGPKVSLSPGPEQKYETEGSSTTGFTSSLSPFSTHITQLMEETTTEKTSLEDIDLGSGLFEKPKATELIEFSTIKVTVPSDITTAFSSVDRLHTTSAFKPSSAITKKPPLIDREPGEETTSDMVIIGESTSHVPPTTLEDIVAKETETDIDREYFTTSSPPATQPTRPPTVEDKEAFGPQALSTPQPPASTKFHPDINVYIIEVRENKTGRMSDLSVIGHPIDSESKEDEPCSEETDPVHDLMAEILPEFPDIIEIDLYHSEENEEEEEECANATDVTTTPSVQYINGKHLVTTVPKDPEAAEARRGQFESVAPSQNFSDSSESDTHPFVIAKTELSTAVQPNESTETTESLEVTWKPETYPETSEHFSGGEPDVFPTVPFHEEFESGTAKKGAESVTERDTEVGHQAHEHTEPVSLFPEESSGEIAIDQESQKIAFARATEVTFGEEVEKSTSVTYTPTIVPSSASAYVSEEEAVTLIGNPWPDDLLSTKESWVEATPRQVVELSGSSSIPITEGSGEAEEDEDTMFTMVTDLSQRNTTDTLITLDTSRIITESFFEVPATTIYPVSEQPSAKVVPTKFVSETDTSEWISSTTVEEKKRKEEEGTTGTASTFEVYSSTQRSDQLILPFELESPNVATSSDSGTRKSFMSLTTPTQSEREMTDSTPVFTETNTLENLGAQTTEHSSIHQPGVQEGLTTLPRSPASVFMEQGSGEAAADPETTTVSSFSLNVEYAIQAEKEVAGTLSPHVETTFSTEPTGLVLSTVMDRVVAENITQTSREIVISERLGEPNYGAEIRGFSTGFPLEEDFSGDFREYSTVSHPIAKEETVMMEGSGDAAFRDTQTSPSTVPTSVHISHISDSEGPSSTMVSTSAFPWEEFTSSAEGSGEQLVTVSSSVVPVLPSAVQKFSGTASSIIDEGLGEVGTVNEIDRRSTILPTAEVEGTKAPVEKEEVKVSGTVSTNFPQTIEPAKLWSRQEVNPVRQEIESETTSEEQIQEEKSFESPQNSPATEQTIFDSQTFTETELKTTDYSVLTTKKTYSDDKEMKEEDTSLVNMSTPDPDANGLESYTTLPEATEKSHFFLATALVTESIPAEHVVTDSPIKKEESTKHFPKGMRPTIQESDTELLFSGLGSGEEVLPTLPTESVNFTEVEQINNTLYPHTSQVESTSSDKIEDFNRMENVAKEVGPLVSQTDIFEGSGSVTSTTLIEILSDTGAEGPTVAPLPFSTDIGHPQNQTVRWAEEIQTSRPQTITEQDSNKNSSTAEINETTTSSTDFLARAYGFEMAKEFVTSAPKPSDLYYEPSGEGSGEVDIVDSFHTSATTQATRQESSTTFVSDGSLEKHPEVPSAKAVTADGFPTVSVMLPLHSEQNKSSPDPTSTLSNTVSYERSTDGSFQDRFREFEDSTLKPNRKKPTENIIIDLDKEDKDLILTITESTILEILPELTSDKNTIIDIDHTKPVYEDILGMQTDIDTEVPSEPHDSNDESNDDSTQVQEIYEAAVNLSLTEETFEGSADVLASYTQATHDESMTYEDRSQLDHMGFHFTTGIPAPSTETELDVLLPTATSLPIPRKSATVIPEIEGIKAEAKALDDMFESSTLSDGQAIADQSEIIPTLGQFERTQEEYEDKKHAGPSFQPEFSSGAEEALVDHTPYLSIATTHLMDQSVTEVPDVMEGSNPPYYTDTTLAVSTFAKLSSQTPSSPLTIYSGSEASGHTEIPQPSALPGIDVGSSVMSPQDSFKEIHVNIEATFKPSSEEYLHITEPPSLSPDTKLEPSEDDGKPELLEEMEASPTELIAVEGTEILQDFQNKTDGQVSGEAIKMFPTIKTPEAGTVITTADEIELEGATQWPHSTSASATYGVEAGVVPWLSPQTSERPTLSSSPEINPETQAALIRGQDSTIAASEQQVAARILDSNDQATVNPVEFNTEVATPPFSLLETSNETDFLIGINEESVEGTAIYLPGPDRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLPSYVGALCEQDTETCDYGWHKFQGQCYKYFAHRRTWDAAERECRLQGAHLTSILSHEEQMFVNRVGHDYQWIGLNDKMFEHDFRWTDGSTLQYENWRPNQPDSFFSAGEDCVVIIWHENGQWNDVPCNYHLTYTCKKGTVACGQPPVVENAKTFGKMKPRYEINSLIRYHCKDGFIQRHLPTIRCLGNGRWAIPKITCMNPSAYQRTYSMKYFKNSSSAKDNSINTSKHDHRWSRRWQESRR"},{"id":"SEQ_03841","a":"P46087","g":"NOP2","d":"28S rRNA (cytosine(4447)-C(5))-methyltransferase","L":812,"m":[{"c":"x[ND][ST][EQ][TL]x[AT][PV]x[NS][PV]x[KL][PT]Q[AV][IST]x[KS]xx[ND][SH][SH]QP[AL][GK]+A[KE]Gφx[KE](x){8,17}[KE]K[AV][AS]F[QL]+[QL]Nxx[PS]KG","u":"57-66","sp":"tandem","x":"disordered_like","cf":"high","why":"Three head-to-tail C-terminal repeats (aa 597-779) in a P/S/T/Q/K-enriched disordered-like tail, each comprising a fixed 24-aa N-terminal segment (anchored by [ND][ST][EQ], Q[AV], and [ND][SH][SH]) followed by two strongly conserved motif cores (QP[AL][GK]+A[KE]Gφx[KE] and [KE]K[AV][AS]F[QL]+[QL]Nxx[PS]KG) separated by an 8-17 aa polar loop.","i":[[597,656,"GNSETATPTNVDLPQVIPKSENSSQPAKKAKGAAKTKQQLQKQQHPKKASFQKLNGISKG"],[657,722,"ADSELSTVPSVTKTQASSSFQDSSQPAGKAEGIREPKVTGKLKQRSPKLQSSKKVAFLRQNAPPKG"],[723,779,"TDTQTPAVLSPSKTQATLKPKDHHQPLGRAKGVEKQQLPEQPFEKAAFQKQNDTPKG"]]}],"s":"MGRKLDPTKEKRGPGRKARKQKGAETELVRFLPAVSDENSKRLSSRARKRAAKRRLGSVEAPKTNKSPEAKPLPGKLPKGISAGAVQTAGKKGPQSLFNAPRGKKRPAPGSDEEEEEEDSEEDGMVNHGDLWGSEDDADTVDDYGADSNSEDEEEGEALLPIERAARKQKAREAAAGIQWSEEETEDEEEEKEVTPESGPPKVEEADGGLQINVDEEPFVLPPAGEMEQDAQAPDLQRVHKRIQDIVGILRDFGAQREEGRSRSEYLNRLKKDLAIYYSYGDFLLGKLMDLFPLSELVEFLEANEVPRPVTLRTNTLKTRRRDLAQALINRGVNLDPLGKWSKTGLVVYDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYMAQLMKNTGVILANDANAERLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGGFDRVLLDAPCSGTGVISKDPAVKTNKDEKDILRCAHLQKELLLSAIDSVNATSKTGGYLVYCTCSITVEENEWVVDYALKKRNVRLVPTGLDFGQEGFTRFRERRFHPSLRSTRRFYPHTHNMDGFFIAKFKKFSNSIPQSQTGNSETATPTNVDLPQVIPKSENSSQPAKKAKGAAKTKQQLQKQQHPKKASFQKLNGISKGADSELSTVPSVTKTQASSSFQDSSQPAGKAEGIREPKVTGKLKQRSPKLQSSKKVAFLRQNAPPKGTDTQTPAVLSPSKTQATLKPKDHHQPLGRAKGVEKQQLPEQPFEKAAFQKQNDTPKGPQPPTVSPIRSSRPPPAKRKKSQSRGNSQLLLS"},{"id":"SEQ_03843","a":"P23327","g":"HRC","d":"Sarcoplasmic reticulum histidine-rich calcium-binding protein","L":699,"m":[{"c":"[VA]Sx[EG][HY][GHR]H[HQ]x[PH][SR]HRx[HG]x(x){0,5}----","u":"20-25","sp":"tandem","x":"disordered_like","cf":"high","why":"Large 16-copy array of 20-25 aa histidine-rich/acidic units anchored by an N-terminal [VA]Sx[EG] motif, conserved central [HY][GHR]H and [PH][SR]HR histidine-basic cores, and a D/E-rich acidic C-terminal tail. Copies are predominantly head-to-tail tandem across a polar/charged disordered region, with occasional short poly-D/E linker extensions.","i":[[53,73,"ASAELRHHLHSPRDHPDENKD"],[74,94,"VSTENGHHFWSHPDREKEDED"],[95,117,"VSKEYGHLLPGHRSQDHKVGDEG"],[123,144,"VFAEHGGQARGHRGHGSEDTED"],[145,167,"SAEHRHHLPSHRSHSHQDEDEDE"],[169,191,"VSSEHHHHILRHGHRGHDGEDDE"],[205,226,"ASTEYGHQAHRHRGHGSEEDED"],[227,248,"VSDGHHHHGPSHRHQGHEEDDD"],[262,283,"VSIEYRHQAHRHQGHGIEEDED"],[284,305,"VSDGHHHRDPSHRHRSHEEDDN"],[310,331,"VSTEYGHQAHRHQDHRKEEVEA"],[332,356,"VSGEHHHHVPDHRHQGHRDEEEDED"],[357,380,"VSTERWHQGPQHVHHGLVDEEEEE"],[383,405,"ITVQFGHYVASHQPRGHKSDEED"],[410,429,"YKTEVPHHHHHRVPREEDEE"],[430,450,"VSAELGHQAPSHRQSHQDEET"]]},{"c":"GxxCxxCo[FH]CoxCxxC(x){2,3}C(x){1,3}C","u":"21-24","sp":"dispersed","x":"structured_like","cf":"high","why":"Strongly conserved C-terminal 2-copy duplication of a 21-24 aa cysteine-rich module containing an N-terminal G anchor and seven aligned cysteines (five CxxC spacings followed by two short variable-length Cys loops), separated by a 5-aa linker.","i":[[624,644,"GSLCGYCSFCNRCTECESCHC"],[650,673,"GEHCDQCQHCQFCYLCPLVCETVC"]]}],"s":"MGHHRPWLHASVLWAGVASLLLPPAMTQQLRGDGLGFRNRNNSTGVAGLSEEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQEYGNYQPGSLCGYCSFCNRCTECESCHCDEENMGEHCDQCQHCQFCYLCPLVCETVCAPGSYVDYFSSSLYQALADMLETPEP"},{"id":"SEQ_03851","a":"Q53ET0","g":"CRTC2","d":"CREB-regulated transcription coactivator 2","L":693,"m":[{"c":"[PS][LH][SG]HPSLx[AS][SP]","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 10-aa copies in the central Pro/Ser-rich disordered region share an invariant HPSL core flanked by constrained N-terminal ([PS][LH][SG]) and C-terminal ([AS][SP]) positions separated by 19-aa and 10-aa linkers.","i":[[337,346,"PLSHPSLQSS"],[366,375,"SHSHPSLPAS"],[386,395,"SLGHPSLSAP"]]}],"s":"MATSGANGPGSATASASNPRKFSEKIALQKQRQAEETAAFEEVMMDIGSTRLQAQKLRLAYTRSSHYGGSLPNVNQIGSGLAEFQSPLHSPLDSSRSTRHHGLVERVQRDPRRMVSPLRRYTRHIDSSPYSPAYLSPPPESSWRRTMAWGNFPAEKGQLFRLPSALNRTSSDSALHTSVMNPSPQDTYPGPTPPSILPSRRGGILDGEMDPKVPAIEENLLDDKHLLKPWDAKKLSSSSSRPRSCEVPGINIFPSPDQPANVPVLPPAMNTGGSLPDLTNLHFPPPLPTPLDPEETAYPSLSGGNSTSNLTHTMTHLGISRGMGLGPGYDAPGLHSPLSHPSLQSSLSNPNLQASLSSPQPQLQGSHSHPSLPASSLARHVLPTTSLGHPSLSAPALSSSSSSSSTSSPVLGAPSYPASTPGASPHHRRVPLSPLSLLAGPADARRSQQQLPKQFSPTMSPTLSSITQGVPLDTSKLSTDQRLPPYPYSSPSLVLPTQPHTPKSLQQPGLPSQSCSVQSSGGQPPGRQSHYGTPYPPGPSGHGQQSYHRPMSDFNLGNLEQFSMESPSASLVLDPPGFSEGPGFLGGEGPMGGPQDPHTFNHQNLTHCSRHGSGPNIILTGDSSPGFSKEIAAALAGVPGFEVSAAGLELGLGLEDELRMEPLGLEGLNMLSDPCALLPDPAVEESFRSDRLQ"},{"id":"SEQ_03861","a":"Q99767","g":"APBA2","d":"Amyloid-beta A4 precursor protein-binding family A member 2","L":749,"m":[{"c":"LGφxV(x){3,12}IψxoψMxGGxAxR(x){2,3}ψxψGxxIψxINGoSψV(x){6,9}Iψx[GA]LxN(x){2,3}[QE]ψ[KH]ψxxψ","u":"62-74","sp":"dispersed","x":"structured_like","cf":"high","why":"Two C-terminal ~62-74 aa globular domain repeats separated by an 18-aa linker conserve multiple hallmark structural motifs including LGφxV, IψxoψMxGGxAxR, IψxINGoSψV, and Iψx[GA]LxN with minor loop length variation.","i":[[579,652,"LGVVVVESGWGSILPTVILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIV"],[671,732,"LGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQALSNSVGEIHMKTM"]]}],"s":"MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEEQECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEEYLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQEEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMTSITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGFKPKTRTPEERLKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGPCEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSEGDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSASQDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQALSNSVGEIHMKTMPAAMFRLLTGQETPLYI"},{"id":"SEQ_03866","a":"Q9Y4C8","g":"RBM19","d":"Probable RNA-binding protein 19","L":960,"m":[{"c":"ψxψ+[NG]φ[PN]xxxxxxxφx[EQK]x[FL][AGS]xφ[GK](x){11,20}[GKI][FYT][GAI][FI][VI]x[FY]xxxxx[AV]x[KRQ]A(x){12,14}[IL]x[VL]","u":"66-75","sp":"dispersed","x":"structured_like","cf":"high","why":"Six dispersed 66-75 aa structured repeat units anchored by a conserved N-terminal ψxψ+[NG]φ[PN] motif, a [FL][AGS]xφ[GK] turn, a central aromatic-hydrophobic [GKI][FYT][GAI][FI][VI]x[FY] core followed by an invariant A, and a C-terminal [IL]x[VL] aliphatic dyad.","i":[[4,74,"LIVKNLPNGMKEERFRQLFAAFGTLTDCSLKFTKDGKFRKFGFIGFKSEEEAQKAQKHFNKSFIDTSRITV"],[296,364,"VKLRGAPFNVTEKNVMEFLAPLKPVAIRIVRNAHGNKTGYIFVDFSNEEEVKQALKCNREYMGGRYIEV"],[404,475,"LFVRNLPYTSTEEDLEKLFSKYGPLSELHYPIDSLTKKPKGFAFITFMFPEHAVKAYSEVDGQVFQGRMLHV"],[589,654,"ILVKNLPAGTLAAQLQETFGHFGSLGRVLLPEGGITAIVEFLEPLEARKAFRHLAYSKFHHVPLYL"],[732,806,"LFIKNLNFDTTEEKLKEVFSKVGTVKSCSISKKKNKAGVLLSMGFGFVEYRKPEQAQKALKQLQGHVVDGHKLEV"],[834,907,"ILVRNIPFQAHSREIRELFSTFGELKTVRLPKKMTGTGTHRGFGFVDFLTKQDAKRAFNALCHSTHLYGRRLVL"]]}],"s":"MSRLIVKNLPNGMKEERFRQLFAAFGTLTDCSLKFTKDGKFRKFGFIGFKSEEEAQKAQKHFNKSFIDTSRITVEFCKSFGDPAKPRAWSKHAQKPSQPKQPPKDSTTPEIKKDEKKKKVAGQLEKLKEDTEFQEFLSVHQRRAQAATWANDGLDAEPSKGKSKPASDYLNFDSDSGQESEEEGAGEDLEEEASLEPKAAVQKELSDMDYLKSKMVKAGSSSSSEEEESEDEAVHCDEGSEAEEEDSSATPVLQERDSKGAGQEQGMPAGKKRPPEARAETEKPANQKEPTTCHTVKLRGAPFNVTEKNVMEFLAPLKPVAIRIVRNAHGNKTGYIFVDFSNEEEVKQALKCNREYMGGRYIEVFREKNVPTTKGAPKNTTKSWQGRILGENEEEEDLAESGRLFVRNLPYTSTEEDLEKLFSKYGPLSELHYPIDSLTKKPKGFAFITFMFPEHAVKAYSEVDGQVFQGRMLHVLPSTIKKEASEDASALGSSSYKKKKEAQDKANSASSHNWNTLFMGPNAVADAIAQKYNATKSQVFDHETKGSVAVRVALGETQLVQEVRRFLIDNGVSLDSFSQAAAERSKTVILVKNLPAGTLAAQLQETFGHFGSLGRVLLPEGGITAIVEFLEPLEARKAFRHLAYSKFHHVPLYLEWAPVGVFSSTAPQKKKLQDTPSEPMEKDPAEPETVPDGETPEDENPTEEGADNSSAKMEEEEEEEEEEEESLPGCTLFIKNLNFDTTEEKLKEVFSKVGTVKSCSISKKKNKAGVLLSMGFGFVEYRKPEQAQKALKQLQGHVVDGHKLEVRISERATKPAVTLARKKQVPRKQTTSKILVRNIPFQAHSREIRELFSTFGELKTVRLPKKMTGTGTHRGFGFVDFLTKQDAKRAFNALCHSTHLYGRRLVLEWADSEVTLQALRRKTAAHFHEPPKKKRSVVLDEILEQLEGSDSDSEEQTLQL"},{"id":"SEQ_03878","a":"Q6IBW4","g":"NCAPH2","d":"Condensin-2 complex subunit H2","L":605,"m":[{"c":"[LM]EP[EA]Gφ[SD]P","u":8,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three 8-residue copies (a head-to-tail pair in the central proline/acidic disordered linker and a dispersed copy in the C-terminal acidic linker) share invariant E2, P3, G5, and P8 anchors flanked by conserved [LM], [EA], hydrophobic (M/V/A), and [SD] positions.","i":[[194,201,"LEPEGMSP"],[202,209,"MEPAGVSP"],[445,452,"MEPEGADP"]]}],"s":"MEDVEARFAHLLQPIRDLTKNWEVDVAAQLGEYLEELDQICISFDEGKTTMNFIEAALLIQGSACVYSKKVEYLYSLVYQALDFISGKRRAKQLSSVQEDRANGVASSGVPQEAENEFLSLDDFPDSRTNVDLKNDQTPSEVLIIPLLPMALVAPDEMEKNNNPLYSRQGEVLASRKDFRMNTCVPHPRGAFMLEPEGMSPMEPAGVSPMPGTQKDTGRTEEQPMEVSVCRSPVPALGFSQEPGPSPEGPMPLGGGEDEDAEEAVELPEASAPKAALEPKESRSPQQSAALPRRYMLREREGAPEPASCVKETPDPWQSLDPFDSLESKPFKKGRPYSVPPCVEEALGQKRKRKGAAKLQDFHQWYLAAYADHADSRRLRRKGPSFADMEVLYWTHVKEQLETLRKLQRREVAEQWLRPAEEDHLEDSLEDLGAADDFLEPEEYMEPEGADPREAADLDAVPMSLSYEELVRRNVELFIATSQKFVQETELSQRIRDWEDTVQPLLQEQEQHVPFDIHTYGDQLVSRFPQLNEWCPFAELVAGQPAFEVCRSMLASLQLANDYTVEITQQPGLEMAVDTMSLRLLTHQRAHKRFQTYAAPSMAQP"},{"id":"SEQ_03897","a":"A5PL33","g":"KRABD3","d":"KRAB domain-containing protein 3","L":1030,"m":[{"c":"[SC]PL[QEH][GAC]Lxx[CA]L+[EG][IL]","u":13,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five dispersed 13-aa motif copies embedded in P/S/G-rich disordered regions share an invariant P2-L3-L6-L10 hydrophobic register flanked by an N-terminal [SC]P cap and C-terminal +[EG][IL] signature (with an additional C-terminally diverged CPLRGLLSCL copy at residues 111-120).","i":[[206,218,"SPLQGLINCLKEI"],[267,279,"CPLQGLLHCLKEL"],[382,394,"SPLEALEACLKGI"],[498,510,"SPLQGLENCLKEI"],[610,622,"SPLHCLESALRGI"]]}],"s":"MRENYETLVSVGTAELLPLSAFLSPSEPGRAVGGGSHADEGQEPAGCGDPQGGQPRHSLHLTALVQLVKEIPEFLFGEVKGAMDSPESESRGASLDGERASPEAAAAREPCPLRGLLSCLPDGPTSQPHLATTPTDSSCSSGPTGDGVQGSPLPIKTADKPWPTRKEGPGALGGEPSPPTHSPSRRKSHRGQERGTSEAGISPGNSPLQGLINCLKEILVPGPRHPETSPSFLPPLPSLGTSRLTRADLGPGSPPWAVKTEAVSGDCPLQGLLHCLKELPEAQDRHPSPSGVGNRRLQENPGAWKRGSGGPGYLLTPPPHPDLGAGGLLSVKMENSWVQSPPGPASCQPGRQPLSPSATGDTRGVPQPSWGPEAQAASASSSPLEALEACLKGIPPNGSSPSQLPPTSCSQNPQPGDSRSQKPELQPHRSHSEEATREPVLPLGLQSCVRDGPSRPLAPRGTPTSFSSSSSTDWDLDFGSPVGNQGQHPGKGSPPGSSPLQGLENCLKEIPVPVLRPAWPCSSAADRGPRRAEPRNWTADKEGLRAEACESARLGQGRGEAPTRSLHLVSPQVFTSSCVPACHQRGFKDPGATRPGVWRWLPEGSAPKPSPLHCLESALRGILPVRPLRFACVGGPSPSPSPGSSSSFSGSEGEDPRPEPDLWKPLPQERDRLPSCKPPVPLSPCPGGTPAGSSGGSPGEDPRRTEPRYCSGLGAGTAQDPCPVSQLEKRPRVSEASRGLELGHGRPRVAAKTHERLLPQGPPELPSESPPPELPPPEAAPPVLPASSLQPPCHCGKPLQQELHSLGAALAEKLDRLATALAGLAQEVATMRTQVNRLGRRPQGPGPMGQASWMWTLPRGPRWAHGPGHRHLPYWRQKGPTRPKPKILRGQGESCRAGDLQGLSRGTARRARPLPPDAPPAEPPGLHCSSSQQLLSSTPSCHAAPPAHPLLAHTGGHQSPLPPLVPAALPLQGASPPAASADADVPTSGVAPDGIPERPKEPSSLLGGVQRALQEELWGGEHRDPRWGAH"},{"id":"SEQ_03899","a":"Q8TF68","g":"ZNF384","d":"Zinc finger protein 384","L":577,"m":[{"c":"[PTV][YFH]xC(x){2,4}Cxx[STA][FY]xxx[STA]x[LM]xxHxxxH[STN]","u":"25-27","sp":"periodic","x":"structured_like","cf":"high","why":"Eight periodic 25-27 aa repeats separated mostly by 3 aa linkers (with 5 and 8 aa variants), anchored by invariant C(x){2,4}C and HxxxH pairs, conserved aromatic/aliphatic core positions ([FY] and [LM]), and flanking [PTV][YFH] and [STN] residues; C-terminal poly-A/AQ/poly-Q/poly-G runs are unanchored low-complexity tracts.","i":[[227,251,"TYRCRMCSLTFYSKSEMQIHSKSHT"],[255,279,"PHKCPHCSKTFANSSYLAQHIRIHS"],[283,307,"PYSCNFCEKSFRQLSHLQQHTRIHS"],[316,340,"PHKCPHCSKTFANTSYLAQHLRIHS"],[344,368,"PYNCSYCQKAFRQLSHLQQHTRIHT"],[372,398,"PYKCAHPGCEKAFTQLSNLQSHRRQHN"],[402,426,"PFKCHNCHRAYTDAASLEVHLSTHT"],[432,456,"VYTCTICSRAYTSETYLMKHMRKHN"]]}],"s":"MEESHFNSNPYFWPSIPTVSGQIENTMFINKMKDQLLPEKGCGLAPPHYPTLLTVPASVSLPSGISMDTESKSDQLTPHSQASVTQNITVVPVPSTGLMTAGVSCSQRWRREGSQSRGPGLVITSPSGSLVTTASSAQTFPISAPMIVSALPPGSQALQVVPDLSKKVASTLTEEGGGGGGGGGSVAPKPPRGRKKKRMLESGLPEMNDPYVLSPEDDDDHQKDGKTYRCRMCSLTFYSKSEMQIHSKSHTETKPHKCPHCSKTFANSSYLAQHIRIHSGAKPYSCNFCEKSFRQLSHLQQHTRIHSKMHTETIKPHKCPHCSKTFANTSYLAQHLRIHSGAKPYNCSYCQKAFRQLSHLQQHTRIHTGDRPYKCAHPGCEKAFTQLSNLQSHRRQHNKDKPFKCHNCHRAYTDAASLEVHLSTHTVKHAKVYTCTICSRAYTSETYLMKHMRKHNPPDLQQQVQAAAAAAAVAQAQAQAQAQAQAQAQAQAQAQASQASQQQQQQQQQQQQQQQQPPPHFQSPGAAPQGGGGGDSNPNPPPQCSFDLTPYKTAEHHKDICLTVTTSTIQVEHLASS"},{"id":"SEQ_03907","a":"Q5VTJ3","g":"KLHDC7A","d":"Kelch domain-containing protein 7A","L":777,"m":[{"c":"[LFI][VYF]xx[DG](x){6,14}[YF](x){6,8}[WF]","u":"21-27","sp":"periodic","x":"structured_like","cf":"high","why":"Six periodic 21-27 aa C-terminal structural repeats separated by regular 21-24 aa linkers, defined by a conserved N-terminal hydrophobic-acidic/glycine core ([LFI][VYF]xx[DG]) followed by an internal [YF] anchor and a C-terminal [WF] residue 6-8 positions downstream.","i":[[494,518,"LVVADVCPKEDSGGLCCYDDEQDVW"],[543,569,"FVVSGCQGPGHQPSSRVFCYNPLTGIW"],[591,612,"LYAIGGECLNSVERYDPRLDRW"],[636,657,"IFVTGGSLRFLLFRFSAQEQRW"],[679,702,"LYRFDLNRSLGIAVYRCSASTRLW"],[725,745,"IYCVGRRSTLCFLADSVSPRF"]]}],"s":"MFPRGAEAQDWHLDMQLTGKVVLSAAALLLVTVAYRLYKSRPAPAQRWGGNGQAEAKEEAEGSGQPAVQEASPGVLLRGPRRRRSSKRAEAPQGCSCENPRGPYVLVTGATSTDRKPQRKGSGEERGGQGSDSEQVPPCCPSQETRTAVGSNPDPPHFPRLGSEPKSSPAGLIAAADGSCAGGEPSPWQDSKPREHPGLGQLEPPHCHYVAPLQGSSDMNQSWVFTRVIGVSREEAGALEAASDVDLTLHQQEGAPNSSYTFSSIARVRMEEHFIQKAEGVEPRLKGKVYDYYVESTSQAIFQGRLAPRTAALTEVPSPRPPPGSLGTGAASGGQAGDTKGAAERAASPQTGPWPSTRGFSRKESLLQIAENPELQLQPDGFRLPAPPCPDPGALPGLGRSSREPHVQPVAGTNFFHIPLTPASAPQVRLDLGNCYEVLTLAKRQNLEALKEAAYKVMSENYLQVLRSPDIYGCLSGAERELILQRRLRGRQYLVVADVCPKEDSGGLCCYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGGECLNSVERYDPRLDRWDFAPPLPSDTFALAHTATVRAKEIFVTGGSLRFLLFRFSAQEQRWWAGPTGGSKDRTAEMVAVNGFLYRFDLNRSLGIAVYRCSASTRLWYECATYRTPYPDAFQCAVVDNLIYCVGRRSTLCFLADSVSPRFVPKELRSFPAPQGTLLPTVLTLPTPDLPQTRV"},{"id":"SEQ_03909","a":"Q05469","g":"LIPE","d":"Hormone-sensitive lipase","L":1076,"m":[{"c":"[TAP]QQ[EKS]xxxx","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Seven copies in the N-terminal P/Q/S/E/K-rich disordered region (residues 47-156) anchored by an invariant QQ dyad, a constrained [TAP] start, an [EKS] fourth position, small/proline fifth position, and predominantly polar eighth position, separated by 4-16 aa linkers.","i":[[47,54,"TQQKPASN"],[59,66,"TQQETPAQ"],[77,84,"AQQKSASQ"],[95,102,"PQQSPYIQ"],[107,114,"TQQEAASQ"],[125,132,"TQQEPALR"],[149,156,"AQQEAEST"]]}],"s":"MEPGSKSVSRSDWQPEPHQRPITPLEPGPEKTPIAQPESKTLQGSNTQQKPASNQRPLTQQETPAQHDAESQKEPRAQQKSASQEEFLAPQKPAPQQSPYIQRVLLTQQEAASQQGPGLGKESITQQEPALRQRHVAQPGPGPGEPPPAQQEAESTPAAQAKPGAKREPSAPTESTSQETPEQSDKQTTPVQGAKSKQGSLTELGFLTKLQELSIQRSALEWKALSEWVTDSESESDVGSSSDTDSPATMGGMVAQGVKLGFKGKSGYKVMSGYSGTSPHEKTSARNHRHYQDTASRLIHNMDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQALGLEPALGRLLGVAHLFDLDPETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALTQLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLHKGCFYGRCLGFQFTPAIRPFLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAIDPELRGAEFERITQNLDVHFWKAFWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGPVLVRLISYDLREGQDSEELSSLIKSNGQRSLELWPRPQQAPRSRSLIVHFHGGGFVAQTSRSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFAYCWAIKHCALLGSTGERICLAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVLSKCVSAYAGAKTEDHSNSDQKALGMMGLVRRDTALLLRDFRLGASSWLNSFLELSGRKSQKMSEPIAEPMRRSVSEAALAQPQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAETLSPSTPSDVNFLLPPEDAGEEAEAKNELSPMDRGLGVRAAFPEGFHPRRSSQGATQMPLYSSPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVEDLPHGFLTLAALCRETRQAAELCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH"},{"id":"SEQ_03913","a":"Q15397","g":"PUM3","d":"Pumilio homolog 3","L":648,"m":[{"c":"[KA][NR]KF[QN][PK]","u":6,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three contiguous head-to-tail hexapeptide repeats in the N-terminal basic/polar disordered tail (residues 79-96) anchored by an invariant KF core and constrained flanking [KA], [NR], [QN], and [PK] positions (with a related upstream KNRFHK motif at residues 20-25).","i":[[79,84,"KNKFQP"],[85,90,"ANKFNK"],[91,96,"KRKFQP"]]}],"s":"MEVKGKKQFTGKSTKTAQEKNRFHKNSDSGSSKTFPTRKVAKEGGPKVTSRNFEKSITKLGKKGVKQFKNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKDCDKEKRVKLMSDLQKLIQGKIKTIAFAHDSTRVIQCYIQYGNEEQRKQAFEELRDDLVELSKAKYSRNIVKKFLMYGSKPQIAEIIRSFKGHVRKMLRHAEASAIVEYAYNDKAILEQRNMLTEELYGNTFQLYKSADHRTLDKVLEVQPEKLELIMDEMKQILTPMAQKEAVIKHSLVHKVFLDFFTYAPPKLRSEMIEAIREAVVYLAHTHDGARVAMHCLWHGTPKDRKVIVKTMKTYVEKVANGQYSHLVLLAAFDCIDDTKLVKQIIISEIISSLPSIVNDKYGRKVLLYLLSPRDPAHTVREIIEVLQKGDGNAHSKKDTEVRRRELLESISPALLSYLQEHAQEVVLDKSACVLVSDILGSATGDVQPTMNAIASLAATGLHPGGKDGELHIAEHPAGHLVLKWLIEQDKKMKENGREGCFAKTLVEHVGMKNLKSWASVNRGAIILSSLLQSCDLEVANKVKAALKSLIPTLEKTKSTSKGIEILLEKLST"},{"id":"SEQ_03914","a":"Q9UKY1","g":"ZHX1","d":"Zinc fingers and homeoboxes protein 1","L":873,"m":[{"c":"[KY]xxxxxxx[LP]xxxxxxx[KQS]φ(x){0,2}[PL]xxx-φxxLxxx[AST]xφ[TAG]xx[EQD][IV]xxWFx[DEA]x[RKQ]xx","u":"48-50","sp":"dispersed","x":"structured_like","cf":"high","why":"Five dispersed ~48-50 aa structured repeats across residues 289-824 sharing invariant L and WF anchors, conserved hydrophobic core positions, an acidic turn residue, and a 2-aa loop insertion in the first copy.","i":[[289,338,"YNAALDNNPLLLNTYNKFPYPTMSEITVLSAQAKYTEEQIKIWFSAQRLK"],[471,518,"KTKEQLAELKVSYLKNQFPHDSEIIRLMKITGLTKGEIKKWFSDTRYN"],[575,622,"KTAEQLRVLQASFLNSSVLTDEELNRLRAQTKLTRREIDAWFTEKKKS"],[667,714,"KTPEQLHMLKSAFVRTQWPSPEEYDKLAKESGLARTDIVSWFGDTRYA"],[777,824,"KFKTGTAILKDYYLKHKFLNEQDLDELVNKSHMGYEQVREWFAERQRR"]]},{"c":"YxCxxCoFxTxxφxφφ[TS]xHxxxxHP","u":25,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 25-aa C2H2-type repeats in the N-terminal region (residues 70-94 and 102-126, separated by a 7-aa linker) sharing eight fixed anchors (Y, C, C, F, T, H, H, P) and conserved internal hydrophobic positions.","i":[[70,94,"YECKYCTFQTPDLNMFTFHVDSEHP"],[102,126,"YVCVECNFLTKRYDALSEHNLKYHP"]]}],"s":"MASRRKSTTPCMVLASEQDPDLELISDLDEGPPVLTPVENTRAESISSDEEVHESVDSDNQQNKKVEGGYECKYCTFQTPDLNMFTFHVDSEHPNVVLNSSYVCVECNFLTKRYDALSEHNLKYHPGEENFKLTMVKRNNQTIFEQTINDLTFDGSFVKEENAEQAESTEVSSSGISISKTPIMKMMKNKVENKRIAVHHNSVEDVPEEKENEIKPDREEIVENPSSSASESNTSTSIVNRIHPSTASTVVTPAAVLPGLAQVITAVSAQQNSNLIPKVLIPVNSIPTYNAALDNNPLLLNTYNKFPYPTMSEITVLSAQAKYTEEQIKIWFSAQRLKHGVSWTPEEVEEARRKQFNGTVHTVPQTITVIPTHISTGSNGLPSILQTCQIVGQPGLVLTQVAGTNTLPVTAPIALTVAGVPSQNNIQKSQVPAAQPTAETKPATAAVPTSQSVKHETALVNPDSFGIRAKKTKEQLAELKVSYLKNQFPHDSEIIRLMKITGLTKGEIKKWFSDTRYNQRNSKSNQCLHLNNDSSTTIIIDSSDETTESPTVGTAQPKQSWNPFPDFTPQKFKEKTAEQLRVLQASFLNSSVLTDEELNRLRAQTKLTRREIDAWFTEKKKSKALKEEKMEIDESNAGSSKEEAGETSPADESGAPKSGSTGKICKKTPEQLHMLKSAFVRTQWPSPEEYDKLAKESGLARTDIVSWFGDTRYAWKNGNLKWYYYYQSANSSSMNGLSSLRKRGRGRPKGRGRGRPRGRPRGSKRINNWDRGPSLIKFKTGTAILKDYYLKHKFLNEQDLDELVNKSHMGYEQVREWFAERQRRSELGIELFEENEEEDEVIDDQEEDEEETDDSDTWEPPRHVKRKLSKSDD"},{"id":"SEQ_03928","a":"Q8IXW0","g":"LMNTD2","d":"Lamin tail domain-containing protein 2","L":634,"m":[{"c":"TGxxV[VA][TV](x){7,17}[SA]DLSxxψxxxxxGF[RP](x){14,48}RHH[KV]TV(x){0,1}WG","u":"63-88","sp":"dispersed","x":"structured_like","cf":"high","why":"High-conservation 2-copy internal domain duplication separated by a 91-aa linker, anchored by three conserved blocks—N-terminal TGxxV[VA][TV], central [SA]DLSxxψxxxxxGF[RP], and C-terminal RHH[KV]TV(x){0,1}WG—separated by variable loops (a partial C-terminal remnant VALSVQNTAESRFGFR at 605-620 lacks the flanking TG and RHHxTVWG motifs).","i":[[181,268,"TGSVEVVTAETLMDPSDLSENIQAPTGEGFRLEDVDWNSVARRYPNLFTNMEPSSKQKQPRPWPQLDTGSPESSGKHSERHHKTVEWG"],[360,422,"TGLKIVAVSCREKFVRIFNPSQESTADLSGMVLKQLVRGFPERLYRFPPGTLLAPRHHVTVWG"]]}],"s":"MRWLRPAGRRREQESVSGHLGPPAGAPAAPETPTCLPDTTPHPAPVVCSADPQLALESLDPRTLRLLWRQRELEIQALRWAIQNGEDARLCHILEEVAGLPPKRSSHSQEKLLQNQVQKLIQELKEQKERAQWEKEHLEERLLQTTRTLQEMEAELQNLQKSCLLQLARSSWVGRMLRSQTGSVEVVTAETLMDPSDLSENIQAPTGEGFRLEDVDWNSVARRYPNLFTNMEPSSKQKQPRPWPQLDTGSPESSGKHSERHHKTVEWGSLPCLNTSSSGGADSDSSSCRPGLPSFVQVIGHPPRDHRASSEQALVQAGSYSRDSEDLQKTHSPRHGEPVLSPQPCTDPDHWSPELLQSPTGLKIVAVSCREKFVRIFNPSQESTADLSGMVLKQLVRGFPERLYRFPPGTLLAPRHHVTVWGEATRSAKKPLRASSSREPVPLLSIRGCATLLLSPKGEVLSEHRIPRRETPAPRVFADGTDLSIDRFPLPEAGPGADTRKPPRPPRPLRKGRVREPRVSRRRPGTRGLLPPVSSGKLFHAREGPARPENPEIPAPQHLPAIPGDPTLPSPPAEAGLGLEDCRLQKEHRVRVCRKSVDRSCPLVALSVQNTAESRFGFRFLSCLPVTADTCRGA"},{"id":"SEQ_03931","a":"Q9P265","g":"DIP2B","d":"Disco-interacting protein 2 homolog B","L":1576,"m":[{"c":"φLxxφLQxx(x){44,50}LxxGDxVφLψYP(x){6,8}φAFYGCLφAxxIPV[PT]ψ(x){22,23}φAxφLTS[EQ]xxψ+xLxxx[EQ]x[GA]xφVxφK[GT]WPxψ(x){23,28}AYψ-ΩxxSxxGxψxGVxψS[RH]xAψx[SA]xCxAψxxxCxφxx[GS]xoIφxxLD(x){25,51}YSVMxxC(x){39,60}FxxLFxxxGLxPxAψ(x){58,61}GxxxxIVxP-(x){10,11}GEI[CW]VoS[RP]xx[GA]xxYΩxxxxxxxxxxxxxxxxxxxxxxxxxxxxRoGφLGFV(x){9,19}GxRH[ND]AxxψV(x){17,33}AVF(x){5,9}ψVVVφExxxxxxxxxxxxxxxxxxxxxxxxxxVGV(x){4,7}ψψP","u":"557-563","sp":"dispersed","x":"structured_like","cf":"high","why":"Large ~560-residue internal duplication of a globular domain separated by an 89-aa linker, anchored by numerous conserved signature blocks across the entire fold including LxxGDxVφLψYP, AFYGCLφAxxIPV, YSVMxxC, GEI[CW]VoS, RoGφLGFV, GxRH[ND]AxxψV, and AVF(x){5,9}ψVVVφE.","i":[[338,900,"ALESALQRWGTTQAKCSCLTALDMTGKPVYTLTYGKLWSRSLKLAYTLLNKLGTKNEPVLKPGDRVALVYPNNDPVMFMVAFYGCLLAEVIPVPIEVPLTRKDAGGQQIGFLLGSCGIALALTSEVCLKGLPKTQNGEIVQFKGWPRLKWVVTDSKYLSKPPKDWQPHISPAGTEPAYIEYKTSKEGSVMGVTVSRLAMLSHCQALSQACNYSEGETIVNVLDFKKDAGLWHGMFANVMNKMHTISVPYSVMKTCPLSWVQRVHAHKAKVALVKCRDLHWAMMAHRDQRDVSLSSLRMLIVTDGANPWSVSSCDAFLSLFQSHGLKPEAICPCATSAEAMTVAIRRPGVPGAPLPGRAILSMNGLSYGVIRVNTEDKNSALTVQDVGHVMPGGMMCIVKPDGPPQLCKTDEIGEICVSSRTGGMMYFGLAGVTKNTFEVIPVNSAGSPVGDVPFIRSGLLGFVGPGSLVFVVGKMDGLLMVSGRRHNADDIVATGLAVESIKTVYRGRIAVFSVSVFYDERIVVVAEQRPDASEEDSFQWMSRVLQAIDSIHQVGVYCLALVP"],[990,1546,"FLAEILQWRAQATPDHVLFMLLNAKGTTVCTASCLQLHKRAERIASVLGDKGHLNAGDNVVLLYPPGIELIAAFYGCLYAGCIPVTVRPPHAQNLTATLPTVRMIVDVSKAACILTSQTLMRLLRSREAAAAVDVKTWPTIIDTDDLPRKRLPQLYKPPTPEMLAYLDFSVSTTGMLTGVKMSHSAVNALCRAIKLQCELYSSRQIAICLDPYCGLGFALWCLCSVYSGHQSVLIPPMELENNLFLWLSTVNQYKIRDTFCSYSVMELCTKGLGNQVEVLKTRGINLSCVRTCVVVAEERPRVALQQSFSKLFKDIGLSPRAVSTTFGSRVNVAICLQGTSGPDPTTVYVDLKSLRHDRVRLVERGAPQSLLLSESGKILPGVKVVIVNPETKGPVGDSHLGEIWVNSPHTASGYYTIYDSETLQADHFNTRLSFGDAAQTLWARTGYLGFVRRTELTAATGERHDALYVVGALDETLELRGLRYHPIDIETSVSRIHRSIAECAVFTWTNLLVVVVELCGSEQEALDLVPLVTNVVLEEHYLIVGVVVVVDPGVIP"]]}],"s":"MAERGLEPSPAAVAALPPEVRAQLAELELELSEGDITQKGYEKKRSKLLSPYSPQTQETDSAVQKELRNQTPAPSAAQTSAPSKYHRTRSGGARDERYRSDIHTEAVQAALAKHKEQKMALPMPTKRRSTFVQSPADACTPPDTSSASEDEGSLRRQAALSAALQQSLQNAESWINRSIQGSSTSSSASSTLSHGEVKGTSGSLADVFANTRIENFSAPPDVTTTTSSSSSSSSIRPANIDLPPSGIVKGMHKGSNRSSLMDTADGVPVSSRVSTKIQQLLNTLKRPKRPPLKEFFVDDSEEIVEVPQPDPNQPKPEGRQMTPVKGEPLGVICNWPPALESALQRWGTTQAKCSCLTALDMTGKPVYTLTYGKLWSRSLKLAYTLLNKLGTKNEPVLKPGDRVALVYPNNDPVMFMVAFYGCLLAEVIPVPIEVPLTRKDAGGQQIGFLLGSCGIALALTSEVCLKGLPKTQNGEIVQFKGWPRLKWVVTDSKYLSKPPKDWQPHISPAGTEPAYIEYKTSKEGSVMGVTVSRLAMLSHCQALSQACNYSEGETIVNVLDFKKDAGLWHGMFANVMNKMHTISVPYSVMKTCPLSWVQRVHAHKAKVALVKCRDLHWAMMAHRDQRDVSLSSLRMLIVTDGANPWSVSSCDAFLSLFQSHGLKPEAICPCATSAEAMTVAIRRPGVPGAPLPGRAILSMNGLSYGVIRVNTEDKNSALTVQDVGHVMPGGMMCIVKPDGPPQLCKTDEIGEICVSSRTGGMMYFGLAGVTKNTFEVIPVNSAGSPVGDVPFIRSGLLGFVGPGSLVFVVGKMDGLLMVSGRRHNADDIVATGLAVESIKTVYRGRIAVFSVSVFYDERIVVVAEQRPDASEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGGIHISQTKQLFLEGSLHPCNILMCPHTCVTNLPKPRQKQPGVGPASVMVGNLVAGKRIAQAAGRDLGQIEENDLVRKHQFLAEILQWRAQATPDHVLFMLLNAKGTTVCTASCLQLHKRAERIASVLGDKGHLNAGDNVVLLYPPGIELIAAFYGCLYAGCIPVTVRPPHAQNLTATLPTVRMIVDVSKAACILTSQTLMRLLRSREAAAAVDVKTWPTIIDTDDLPRKRLPQLYKPPTPEMLAYLDFSVSTTGMLTGVKMSHSAVNALCRAIKLQCELYSSRQIAICLDPYCGLGFALWCLCSVYSGHQSVLIPPMELENNLFLWLSTVNQYKIRDTFCSYSVMELCTKGLGNQVEVLKTRGINLSCVRTCVVVAEERPRVALQQSFSKLFKDIGLSPRAVSTTFGSRVNVAICLQGTSGPDPTTVYVDLKSLRHDRVRLVERGAPQSLLLSESGKILPGVKVVIVNPETKGPVGDSHLGEIWVNSPHTASGYYTIYDSETLQADHFNTRLSFGDAAQTLWARTGYLGFVRRTELTAATGERHDALYVVGALDETLELRGLRYHPIDIETSVSRIHRSIAECAVFTWTNLLVVVVELCGSEQEALDLVPLVTNVVLEEHYLIVGVVVVVDPGVIPINSRGEKQRMHLRDSFLADQLDPIYVAYNM"},{"id":"SEQ_03934","a":"Q0VG99","g":"MESP2","d":"Mesoderm posterior protein 2","L":397,"m":[{"c":"W[GAT][STP]P[SPQ]xCPxxQ[AS][APS]P","u":14,"sp":"periodic","x":"disordered_like","cf":"high","why":"Three 14-aa repeats in a proline/serine-rich disordered region separated by exact 12-aa linkers (26-aa periodicity), strongly anchored by six invariant positions (W1, P4, C7, P8, Q11, P14) and constrained polar/small positions.","i":[[220,233,"WGSPSACPGAQAAP"],[246,259,"WATPPYCPKIQSPP"],[272,285,"WTPPQGCPWTQSSP"]]}],"s":"MAQSPPPQSLLGHDHWIFAQGWGWAGHWDSTSPASSSDSSGSCPCDGARGLPQPQPPSCSSRAAEAAATTPRRARTGPAGGQRQSASEREKLRMRTLARALHELRRFLPPSLAPAGQSLTKIETLRLAIRYIGHLSAVLGLSEESLQCRRRQRGDAGSPWGCPLCPDRGPAEAQTQAEGQGQGQGQGQGQGQGQGQGQGQGQGQGRRPGLVSAVLAEASWGSPSACPGAQAAPERLGRGVHDTDPWATPPYCPKIQSPPYSSQGTTSDASLWTPPQGCPWTQSSPEPRNPPVPWTAAPATLELAAVYQGLSVSPEPCLSLGAPSLLPHPSCQRLQPQTPGRCWSHSAEVVPNSEDQGPGAAFQLSEASPPQSSGLRFSGCPELWQEDLEGARLGIFY"},{"id":"SEQ_03935","a":"Q5R3F8","g":"ELFN2","d":"Protein phosphatase 1 regulatory subunit 29","L":820,"m":[{"c":"xx[LV]xx[LI]x[LV]xxNx[LI]xxψxxxx[LF]xxx","u":24,"sp":"tandem","x":"structured_like","cf":"high","why":"Five head-to-tail 24-residue repeats in the N-terminal structured region defined by an invariant N11 anchor and strictly conserved hydrophobic core positions ([LV]3, [LI]6, [LV]8, [LI]13, ψ16, [LF]21).","i":[[55,78,"STVHDLRLNENKLKAVLYSSLNRF"],[79,102,"GNLTDLNLTKNEISYIEDGAFLGQ"],[103,126,"SSLQVLQLGYNKLSNLTEGMLRGM"],[127,150,"SRLQFLFVQHNLIEVVTPTAFSEC"],[151,174,"PSLISIDLSSNRLSRLDGATFASL"]]}],"s":"MLRLGLCAAALLCVCRPGAVRADCWLIEGDKGYVWLAICSQNQPPYETIPQHINSTVHDLRLNENKLKAVLYSSLNRFGNLTDLNLTKNEISYIEDGAFLGQSSLQVLQLGYNKLSNLTEGMLRGMSRLQFLFVQHNLIEVVTPTAFSECPSLISIDLSSNRLSRLDGATFASLASLMVCELAGNPFNCECDLFGFLAWLVVFNNVTKNYDRLQCESPREFAGYPLLVPRPYHSLNAITVLQAKCRNGSLPARPVSHPTPYSTDAQREPDENSGFNPDEILSVEPPASSTTDASAGPAIKLHHVTFTSATLVVIIPHPYSKMYILVQYNNSYFSDVMTLKNKKEIVTLDKLRAHTEYTFCVTSLRNSRRFNHTCLTFTTRDPVPGDLAPSTSTTTHYIMTILGCLFGMVIVLGAVYYCLRKRRMQEEKQKSVNVKKTILEMRYGADVDAGSIVHAAQKLGEPPVLPVSRMASIPSMIGEKLPTAKGLEAGLDTPKVATKGNYIEVRTGAGGDGLARPEDDLPDLENGQGSAAEISTIAKEVDKVNQIINNCIDALKLDSASFLGGGSSSGDPELAFECQSLPAAAAASSATGPGALERPSFLSPPYKESSHHPLQRQLSADAAVTRKTCSVSSSGSIKSAKVFSLDVPDHPAATGLAKGDSKYIEKGSPLNSPLDRLPLVPAGSGGGSGGGGGIHHLEVKPAYHCSEHRHSFPALYYEEGADSLSQRVSFLKPLTRSKRDSTYSQLSPRHYYSGYSSSPEYSSESTHKIWERFRPYKKHHREEVYMAAGHALRKKVQFAKDEDLHDILDYWKGVSAQQKL"},{"id":"SEQ_03943","a":"Q7Z460","g":"CLASP1","d":"CLIP-associating protein 1","L":1538,"m":[{"c":"ψxxφxxxx(x){6,7}[VI]+xxxxxx[LI]xx[LI]φ","u":"27-28","sp":"dispersed","x":"structured_like","cf":"high","why":"Seven conserved 27-28 aa alpha-helical repeat units distributed across the structured regions, anchored by an invariant [VI]+ dyad at the second helix N-terminus and phased hydrophobic positions (ψxxφ in helix A and [LI]xx[LI]φ in helix B) flanking a 6-7 residue turn.","i":[[93,119,"LPSLIDRLGDAKDSVREQDQTLLLKIM"],[169,195,"VPHICNLLGDPNSQVRDAAINSLVEIY"],[446,472,"IPVITSNCTSKSVAVRRRCFEFLDLLL"],[979,1006,"LMRFIVDQTQTPNLKVKVAILKYIESLA"],[1024,1051,"VSRIITWTTEPKSSDVRKAAQIVLISLF"],[1347,1374,"ILLLLLETLGDKDHSIRALALRVLREIL"],[1466,1492,"IPGLLQGYDNTESSVRKASVFCLVAIY"]]},{"c":"[GE][CS]SR-TS[PR]","u":8,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three non-overlapping 8-aa copies within the central S/R/P-rich disordered linker sharing an invariant SR[DE]TS core flanked by [GE][CS] and [PR], with the first two copies embedded in a larger local duplication and the third immediately tandem to the second.","i":[[725,732,"GCSRETSP"],[751,758,"GCSRDTSR"],[759,766,"ESSRDTSP"]]}],"s":"MEPRMESCLAQVLQKDVGKRLQVGQELIDYFSDKQKSADLEHDQTMLDKLVDGLATSWVNSSNYKVVLLGMDILSALVTRLQDRFKAQIGTVLPSLIDRLGDAKDSVREQDQTLLLKIMDQAANPQYVWDRMLGGFKHKNFRTREGICLCLIATLNASGAQTLTLSKIVPHICNLLGDPNSQVRDAAINSLVEIYRHVGERVRADLSKKGLPQSRLNVIFTKFDEVQKSGNMIQSANDKNFDDEDSVDGNRPSSASSTSSKAPPSSRRNVGMGTTRRLGSSTLGSKSSAAKEGAGAVDEEDFIKAFDDVPVVQIYSSRDLEESINKIREILSDDKHDWEQRVNALKKIRSLLLAGAAEYDNFFQHLRLLDGAFKLSAKDLRSQVVREACITLGHLSSVLGNKFDHGAEAIMPTIFNLIPNSAKIMATSGVVAVRLIIRHTHIPRLIPVITSNCTSKSVAVRRRCFEFLDLLLQEWQTHSLERHISVLAETIKKGIHDADSEARIEARKCYWGFHSHFSREAEHLYHTLESSYQKALQSHLKNSDSIVSLPQSDRSSSSSQESLNRPLSAKRSPTGSTTSRASTVSTKSVSTTGSLQRSRSDIDVNAAASAKSKVSSSSGTTPFSSAAALPPGSYASLGRIRTRRQSSGSATNVASTPDNRGRSRAKVVSQSQRSRSANPAGAGSRSSSPGKLLGSGYGGLTGGSSRGPPVTPSSEKRSKIPRSQGCSRETSPNRIGLARSSRIPRPSMSQGCSRDTSRESSRDTSPARGFPPLDRFGLGQPGRIPGSVNAMRVLSTSTDLEAAVADALKKPVRRRYEPYGMYSDDDANSDASSVCSERSYGSRNGGIPHYLRQTEDVAEVLNHCASSNWSERKEGLLGLQNLLKSQRTLSRVELKRLCEIFTRMFADPHSKRVFSMFLETLVDFIIIHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRDSFPFDQQFNILMRFIVDQTQTPNLKVKVAILKYIESLARQMDPTDFVNSSETRLAVSRIITWTTEPKSSDVRKAAQIVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLKNSSNTSVGSPSNTIGRTPSRHTSSRTSPLTSPTNCSHGGLSPSRLWGWSADGLAKHPPPFSQPNSIPTAPSHKALRRSYSPSMLDYDTENLNSEEIYSSLRGVTEAIEKFSFRSQEDLNEPIKRDGKKECDIVSRDGGAASPATEGRGGSEVEGGRTALDNKTSLLNTQPPRAFPGPRARDYNPYPYSDAINTYDKTALKEAVFDDDMEQLRDVPIDHSDLVADLLKELSNHNERVEERKGALLELLKITREDSLGVWEEHFKTILLLLLETLGDKDHSIRALALRVLREILRNQPARFKNYAELTIMKTLEAHKDSHKEVVRAAEEAASTLASSIHPEQCIKVLCPIIQTADYPINLAAIKMQTKVVERIAKESLLQLLVDIIPGLLQGYDNTESSVRKASVFCLVAIYSVIGEDLKPHLAQLTGSKMKLLNLYIKRAQTTNSNSSSSSDVSTHS"},{"id":"SEQ_03948","a":"Q86WP2","g":"GPBP1","d":"Vasculin","L":473,"m":[{"c":"KNG[LI][RLI]","u":5,"sp":"tandem","x":"mixed","cf":"high","why":"Three contiguous head-to-tail 5-aa repeats near the C-terminus at the junction between an alpha-helical segment and the acidic disordered tail, defined by an invariant KNG tripeptide followed by aliphatic [LI] and [RLI] positions.","i":[[424,428,"KNGLR"],[429,433,"KNGIL"],[434,438,"KNGLI"]]}],"s":"MAQHDFAPAWLNFPTPPSSTKSSLNFEKHSENFAWTENRYDVNRRRHNSSDGFDSAIGRPNGGNFGRKEKNGWRTHGRNGTENINHRGGYHGGSSRSRSSIFHAGKSQGLHENNIPDNETGRKEDKRERKQFEAEDFPSLNPEYEREPNHNKSLAAGVWEYPPNPKSRAPRMLVIKKGNTKDLQLSGFPVVGNLPSQPVKNGTGPSVYKGLVPKPAAPPTKPTQWKSQTKENKVGTSFPHESTFGVGNFNAFKSTAKNFSPSTNSVKECNRSNSSSPVDKLNQQPRLTKLTRMRTDKKSEFLKALKRDRVEEEHEDESRAGSEKDDDSFNLHNSNSTHQERDINRNFDENEIPQENGNASVISQQIIRSSTFPQTDVLSSSLEAEHRLLKEMGWQEDSENDETCAPLTEDEMREFQVISEQLQKNGLRKNGILKNGLICDFKFGPWKNSTFKPTTENDDTETSSSDTSDDDDV"},{"id":"SEQ_03959","a":"Q96PX9","g":"PLEKHG4B","d":"Pleckstrin homology domain-containing family G member 4B","L":1627,"m":[{"c":"DRxP[DK][CS]φVx[SG]","u":10,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three contiguous head-to-tail 10-aa repeats in the C-terminal disordered tail anchored by invariant D1, R2, P4, and V8 positions along with conserved [DK]5, [CS]6, hydrophobic φ7 (A/I), and [SG]10.","i":[[1491,1500,"DRTPDCAVIS"],[1501,1510,"DRAPKCAVMS"],[1511,1520,"DRVPDSIVKG"]]}],"s":"MGFSTADGGGGPGARDLESLDACIQRTLSALYPPFEATAATVLWQLFSVAERCHGGDGLHCLTSFLLPAKRALQHLQQEACARYRGLVFLHPGWPLCAHEKVVVQLASLHGVRLQPGDFYLQVTSAGKQSARLVLKCLSRLGRGTEEVTVPEAMYGCVFTGAFLEWVNRERRHVPLQTCLLTSGLAVHRAPWSDVTDPVFVPSPGAILQSYSSCTGPERLPSSPSEAPVPTQATAGPHFQGSASCPDTLTSPCRRGHTGSDQLRHLPYPERAELGSPRTLSGSSDRDFEKVSPSEQGPRMPPENCGGSGERPDPMDQEDRPKALTFHTDLGIPSSRRRPPGDPTCVQPRRWFRESYMEALRNPMPLGSSEEALGDLACSSLTGASRDLGTGAVASGTQEETSGPRGDPQQTPSLEKERHTPSRTGPGAAGRTLPRRSRSWERAPRSSRGAQAAACHTSHHSAGSRPGGHLGGQAVGTPNCVPVEGPGCTKEEDVLASSACVSTDGGSLHCHNPSGPSDVPARQPHPEQEGWPPGTGDFPSQVPKQVLDVSQELLQSGVVTLPGTRDRHGRAVVQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGLVVLVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVDKESAFRPDKDAIIQCEVVSSLKAVHKFVDSCQLTADLDGSFPYSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSLNTHRTPRTAQEVAELIDQHETMMKLVLEDPLLVSLRLEGGTVLARLRREELGTEDSRDTLEAATSLYDRVDEEVHRLVLTSNNRLQQLEHLRELASLLEGNDQQSCQKGLQLAKENPQRTEEMVQDFRRGLSAVVSQAECREGELARWTRSSELCETVSSWMGPLDPEACPSSPVAECLRSCHQEATSVAAEAFPGAGVAVLKPHALGKPWASQQDLWLQYPQTRLRLEEALSEAAPDPSLPPLAQSPPKHERAQEAMRRHQKPPSFPSTDSGGGAWEPAQPLSGLPGRALLCGQDGETLRPGLCALWDPLSLLRGLPGAGATTAHLEDSSACSSEPTQTLASRPRKHPQKKMIKKTQSFEIPQPDSGPRDSCQPDHTSVFSKGLEVTSTVATEKKLPLWQHARSPPVTQSRSLSSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDLPQGLRGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQELGELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKKYLRHVFLFEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYILQASSAEVKSAWTDVIGRILWRQALKSRELRIQEMASMGIGNQPFMDVKPRDRTPDCAVISDRAPKCAVMSDRVPDSIVKGTESQMRGSTAVSSSDHAAPFKRPHSTISDSSTSSSSSQSSSILGSLGLLVSSSPAHPGLWSPAHSPWSSDIRACVEEDEPEPELETGTQAAVCEGAPAVLLSRTRQA"},{"id":"SEQ_03960","a":"Q9UL68","g":"MYT1L","d":"Myelin transcription factor 1-like protein","L":1186,"m":[{"c":"CP[TV]PGC[DT]GxGH[VI][STN][GS]xxxxHRSφ[SY]GCPx[AK]","u":28,"sp":"dispersed","x":"structured_like","cf":"high","why":"Six dispersed 28-aa CCHC-type zinc-binding repeats anchored by invariant CPxPGC, GxGH, HRS, and GCP motifs with conserved hydrophobic/polar core positions.","i":[[31,58,"CPTPGCDGSGHVSGKYARHRSVYGCPLA"],[506,533,"CPTPGCDGTGHVTGLYPHHRSLSGCPHK"],[550,577,"CPTPGCTGRGHVNSNRNSHRSLSGCPIA"],[905,932,"CPTPGCDGSGHITGNYASHRSLSGCPRA"],[954,981,"CPVPGCDGQGHITGKYASHRSASGCPLA"],[1007,1034,"CPTPGCDGSGHVSGSFLTHRSLSGCPRA"]]}],"s":"MEVDTEEKRHRTRSKGVRVPVEPAIQELFSCPTPGCDGSGHVSGKYARHRSVYGCPLAKKRKTQDKQPQEPAPKRKPFAVKADSSSVDECDDSDGTEDMDEKEEDEGEEYSEDNDEPGDEDEEDEEGDREEEEEIEEEDEDDDEDGEDVEDEEEEEEEEEEEEEEEENEDHQMNCHNTRIMQDTEKDDNNNDEYDNYDELVAKSLLNLGKIAEDAAYRARTESEMNSNTSNSLEDDSDKNENLGRKSELSLDLDSDVVRETVDSLKLLAQGHGVVLSENMNDRNYADSMSQQDSRNMNYVMLGKPMNNGLMEKMVEESDEEVCLSSLECLRNQCFDLARKLSETNPQERNPQQNMNIRQHVRPEEDFPGRTPDRNYSDMLNLMRLEEQLSPRSRVFASCAKEDGCHERDDDTTSVNSDRSEEVFDMTKGNLTLLEKAIALETERAKAMREKMAMEAGRRDNMRSYEDQSPRQLPGEDRKPKSSDSHVKKPYYGKDPSRTEKKESKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRVPPEILAMHESVLKCPTPGCTGRGHVNSNRNSHRSLSGCPIAAAEKLAKAQEKHQSCDVSKSSQASDRVLRPMCFVKQLEIPQYGYRNNVPTTTPRSNLAKELEKYSKTSFEYNSYDNHTYGKRAIAPKVQTRDISPKGYDDAKRYCKDPSPSSSSTSSYAPSSSSNLSCGGGSSASSTCSKSSFDYTHDMEAAHMAATAILNLSTRCREMPQNLSTKPQDLCATRNPDMEVDENGTLDLSMNKQRPRDSCCPILTPLEPMSPQQQAVMNNRCFQLGEGDCWDLPVDYTKMKPRRIDEDESKDITPEDLDPFQEALEERRYPGEVTIPSPKPKYPQCKESKKDLITLSGCPLADKSIRSMLATSSQELKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGIRIAQSKEDKEDQEPIRCPVPGCDGQGHITGKYASHRSASGCPLAAKRQKDGYLNGSQFSWKSVKTEGMSCPTPGCDGSGHVSGSFLTHRSLSGCPRATSAMKKAKLSGEQMLTIKQRASNGIENDEEIKQLDEEIKELNESNSQMEADMIKLRTQITTMESNLKTIEEENKVIEQQNESLLHELANLSQSLIHSLANIQLPHMDPINEQNFDAYVTTLTEMYTNQDRYQSPENKALLENIKQAVRGIQV"},{"id":"SEQ_03964","a":"O60749","g":"SNX2","d":"Sorting nexin-2","L":519,"m":[{"c":"-[DA]x[EG]D[LI]F","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 7-aa acidic-hydrophobic-aromatic motifs in the disordered P/S/E/D-rich N-terminal tail sharing an invariant D[LI]F C-terminal anchor preceded by conserved upstream acidic residues.","i":[[22,28,"EDGEDLF"],[68,74,"DDREDLF"],[134,140,"EANGDIF"]]}],"s":"MAAEREPPPLGDGKPTDFEDLEDGEDLFTSTVSTLESSPSSPEPASLPAEDISANSNGPKPTEVVLDDDREDLFAEATEEVSLDSPEREPILSSEPSPAVTPVTPTTLIAPRIESKSMSAPVIFDRSREEIEEEANGDIFDIEIGVSDPEKVGDGMNAYMAYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTKVKVGKEDSSSTEFVEKRRAALERYLQRTVKHPTLLQDPDLRQFLESSELPRAVNTQALSGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLDQQLRKLHVSVEALVCHRKELSANTAAFAKSAAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQAFADFYMFSELLSDYIRLIAAVKGVFDHRMKCWQKWEDAQITLLKKREAEAKMMVANKPDKIQQAKNEIREWEAKVQQGERDFEQISKTIRKEVGRFEKERVKDFKTVIIKYLESLVQTQQQLIKYWEAFLPEAKAIA"},{"id":"SEQ_03973","a":"Q8WZ75","g":"ROBO4","d":"Roundabout homolog 4","L":1007,"m":[{"c":"PxDxψφxx[GP]xxφxψxC(x){3,4}G[QH]P[PE]PT[IV]xWφx[ND]G[QK]PL(x){10,12}[DG]G[ST]LL(x){9,20}GxYxCxA[ST]NxφGxxxSR[GA]AR[LV]S[VI]","u":"83-95","sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 83-95 aa structured repeat units separated by a 10 aa linker in the N-terminal region, anchored by paired cysteines, an invariant tryptophan-proline block (G[QH]P[PE]PT[IV]xWφx[ND]G[QK]PL), an internal [DG]G[ST]LL hydrophobic segment, and a conserved C-terminal GxYxCxA[ST]NxφGxxxSR[GA]AR[LV]S[VI] signature.","i":[[38,132,"PQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSV"],[143,225,"PRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSI"]]}],"s":"MGSGGDSLLGGRGSLPLLLLLIMGGMAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQSAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPAENHNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLEIATHMPGSYCVQVAAVTGAGAGEPSRPVCLLLEQAMERATQEPSEHGPWTLEQLRATLKRPEVIATCGVALWLLLLGTAVCIHRRRRARVHLGPGLYRYTSEDAILKHRMDHSDSQWLADTWRSTSGSRDLSSSSSLSSRLGADARDPLDCRRSLLSWDSRSPGVPLLPDTSTFYGSLIAELPSSTPARPSPQVPAVRRLPPQLAQLSSPCSSSDSLCSRRGLSSPRLSLAPAEAWKAKKKQELQHANSSPLLRGSHSLELRACELGNRGSKNLSQSPGAVPQALVAWRALGPKLLSSSNELVTRHLPPAPLFPHETPPTQSQQTQPPVAPQAPSSILLPAAPIPILSPCSPPSPQASSLSGPSPASSRLSSSSLSSLGEDQDSVLTPEEVALCLELSEGEETPRNSVSPMPRAPSPPTTYGYISVPTASEFTDMGRTGGGVGPKGGVLLCPPRPCLTPTPSEGSLANGWGSASEDNAASARASLVSSSDGSFLADAHFARALAVAVDSFGFGLEPREADCVFIDASSPPSPRDEIFLTPNLSLPLWEWRPDWLEDMEVSHTQRLGRGMPPWPPDSQISSQRSQLHCRMPKAGASPVDYS"},{"id":"SEQ_03985","a":"Q9P2K3","g":"RCOR3","d":"REST corepressor 3","L":495,"m":[{"c":"WTxE-xψLφxQ[AG]φxxxGKxFxxIxxψψ[PG][DN]KTψ[AG]oψxxΩΩφoΩ++","u":44,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two ungapped 44-residue globular repeat domains separated by ~156 residues, sharing 11 identical anchor residues (WT, E, L, Q, GK, F, I, KT) and extensive conserved hydrophobic/aliphatic cores and C-terminal aromatic-basic (ΩΩφoΩ++) motifs.","i":[[89,132,"WTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKK"],[290,333,"WTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVGQVKNFFVNYRR"]]},{"c":"[AP][TL][LH][NR]QPPP[LP][LQ]","u":10,"sp":"periodic","x":"disordered_like","cf":"high","why":"Three regularly spaced 10-residue motifs (8-9 aa linkers) in the C-terminal proline-rich disordered tail anchored by an invariant QPPP core, conserved N-terminal flanking residues (especially [AP]TLN in copies 1 and 3), and C-terminal leucine positions.","i":[[409,418,"ATLNQPPPLL"],[427,436,"ALHRQPPPLQ"],[446,455,"PTLNQPPPPL"]]}],"s":"MRVGAEYQARIPEFDPGATKYTDKDNGGMLVWSPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKLANRHNQGDSDDDVEETHPMDGNDSDYDPKKEAKKEGNTEQPVQTSKIGLGRREYQSLQHRHHSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQVNSALKQKMEGGIEEFKPPESNQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVGQVKNFFVNYRRRFNLEEVLQEWEAEQGTQASNGDASTLGEETKSASNVPSGKSTDEEEEAQTPQAPRTLGPSPPAPSSTPTPTAPIATLNQPPPLLRPTLPAAPALHRQPPPLQQQARFIQPRPTLNQPPPPLIRPANSMPPRLNPRPVLSTVGGQQPPSLIGIQTDSQSSLH"},{"id":"SEQ_03990","a":"Q9NYF8","g":"BCLAF1","d":"Bcl-2-associated transcription factor 1","L":920,"m":[{"c":"φx[ST]LVH[SH]VK(x){0,1}EQ[EY]F+Sφφxxψ","u":"20-21","sp":"periodic","x":"structured_like","cf":"high","why":"Internal duplication of a 20-21 aa amphipathic helical unit separated by a 16-aa linker, anchored by nine invariant residues (LVH..VK.EQ.F.S), a conserved basic position (+), and flanking hydrophobic positions (φ, ψ) with a single-residue insertion in copy 1.","i":[[572,592,"ASTLVHSVKKEQEFRSIFDHI"],[609,628,"IVSLVHHVKEQYFKSAAMTL"]]}],"s":"MGRSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYSSRSRSRTYSRSRSRDRMYSRDYRRDYRNNRGMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRSRSPKRRSVSSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSAYDNSPRSPHSPSPIATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAKTIAPQNAPRDESRGRSSFYPDGGDQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEASKEKGSEKGRAEGEWEDQEALDYFSDKESGKQKFNDSEGDDTEETEDYRQFRKSVLADQGKSFATASHRNTEEEGLKYKSKVSLKGNRESDGFREEKNYKLKETGYVVERPSTTKDKHKEEDKNSERITVKKETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTFREESPLRIKMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLNERFTSYQKATEEHSTRQKSPEIHRRIDISPSTLRKHTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDRRRKERSKERGDSKGSRESSGSRKQEKTPKDYKEYKSYKDDSKHKREQDHSRSSSSSASPSSPSSREEKESKKEREEEFKTHHEMKEYSGFAGVSRPRGTFFRIRGRGRARGVFAGTNTGPNNSNTTFQKRPKEEEWDPEYTPKSKKYFLHDDRDDGVDYWAKRGRGRGTFQRGRGRFNFKKSGSSPKWTHDKYQGDGIVEDEEETMENNEEKKDRRKEEKE"},{"id":"SEQ_04003","a":"O43236","g":"SEPTIN4","d":"Septin-4","L":996,"m":[{"c":"KP[GS]AKVφVS[AS]QxxS[EN]VxT","u":18,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Two dispersed 18-aa copies in the long N-terminal disordered region share 10/18 exact identities and 14/18 conserved positions, anchored by an N-terminal KP[GS]AKVφVS[AS]Q block.","i":[[6,23,"KPGAKVAVSAQRGSEVTT"],[306,323,"KPSAKVLVSSQVESNVRT"]]}],"s":"MVKTNKPGAKVAVSAQRGSEVTTNTSPQQGHGYVLASSHRSAAVSLNPSHRRSEAAHPTTPHSASDYPRSVSLQSGPGHYAVPTPRGPETGPRTESSRHSSPHLKSQKTQTLASHASSRQWKVSPPREEAARRGSESKSGREVGHHASSIPDAKSTHQLSFQDQKNNLQSQILEDDPPSKVQNPQGVRVPRRILSYPKDEAVQTEPIQRITTTSEIRSPRSPSLLEHGSSCVSADYQTAQRRVPVEESETGPYGPIPSKPKALYRNMNLDSLLKLSVLKDSDGVHRVSARVDPESLHKYSAYPETKPSAKVLVSSQVESNVRTPIRGNSEVGRRVTISPGVQSVEPTHHVTVPSVSEGSHKSSMFVTPEPIYKQQTQKPPEITYMSQGPTPRYPELSQKPSIHAELELTPRPLPPRSLPRYGPDSSWWPLLNPEVETPQSQLTTPDFEPKCSPSLDLLLSGFKIDSSPFCEDLKFQREKASLSPPSPPKEFPSWAPLSEVPQTPKHTCKQPIQRFTAFFLDVSEEMYNRVIWWLKDEEIKRFLEDTTDDGELSKFVKDFSGNASCHPPEAKTWASRPQVPEPRPQAPDLYDDDLEFRPPSRPQSSDNQQYFCAPAPLSPSARPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVDHKKRKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVPPGTDPETEKLIREKDEELRRMQEMLHKIQKQMKENY"},{"id":"SEQ_04008","a":"Q8NAT2","g":"TDRD5","d":"Tudor domain-containing protein 5","L":981,"m":[{"c":"φ[ST]x[GP]xDxWD-[NS]WxPxxφxxG","u":20,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Two well-conserved 20-aa repeats in the C-terminal disordered region are anchored by an invariant di-tryptophan DxWD-[NS]WxP core flanked by conserved N-terminal φ[ST]x[GP] and C-terminal φxxG positions.","i":[[733,752,"VTIGDDIWDENWLPLQAKMG"],[785,804,"FSTPKDTWDDSWQPSGLVNG"]]}],"s":"MSEQERIQECLRKEIRSLLISTKDGLSPQELEKEYLLMVGNHLPLRILGYRSTMELVLDMPDVVRVCPGAGGTVILKAIPDESTKGIASLVAKQRSSHKLRNSMHKGRPSIYSGPRSHRRVPYRGRVAPILPAVVKSELKDLLALSPVLLSDFEKAFAKRFGRSFQYMQYGFLSMFEVLNAASDVISVEQTRAGSLLMLKKSVTEEKPRGCPAGKIFTQPFRMKQGSYSTGFPVAKPCFSQPTSNMEPPKQIMSMEKTSKLNVVETSRLNHTEKLNQLENTFKSVIAQIGPGGTISSELKHKIKFVVSKFPEGLFISKLLGEYEVIFKEQLSPKKLGFLNVTELVGALSDILHVEFRKGHQDLLVFDADKKPLPPVQSDKKIEAKACVSSPPRNSLSTAAVKETVWNCPSKKQKEPQQKICKKPNLVVKPLQLQVETNKSELNLAMANHDIPPDAVPNKKLCRLPPLDTSSLIGVFVEYIISPSQFYIRIYSRDSSELLEDMMIEMRRCYSNQLVSDRYVMPECFIQPGHLCCVRISEDKWWYRVIIHRVLEKQEVEVFYPDFGNIGIVQKSSLRFLKCCYTKLPAQAIPCSLAWVRPVEEHWTSKAILQFQKLCGLKPLVGVVDEYVDGILNIFLCDTSSNEDVYFHHVLRTEGHAIVCRENISSKGFSELNPLALYTTSSGGPEDIVLTELGYPSQQHYFNEDRKISPQSKESELRILDEIPTGMPCLESVTIGDDIWDENWLPLQAKMGKGGDAASHLFTASLGGKNQYSSCKEMPQKDWCFSTPKDTWDDSWQPSGLVNGTKVEVHKPEVLGAQEKNTGTNRTQKQLDINGSSDSSTLPKLEEFCTSLTQSEQSADGSQSEPNNSQTQPKQIQLSTAAPCSTTAVDDSAEKPSGSVESSPEILKNEDFSSSRAITLYKDKRQESVDQLSLILSYECQISQKLYIPRSTATAALGAAARLATSRSLLHWYPSVKRMEA"},{"id":"SEQ_04032","a":"Q9NP70","g":"AMBN","d":"Ameloblastin","L":447,"m":[{"c":"P[ES]LPGψDF[AP]DPQG","u":13,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three head-to-tail tandem 13-residue repeats in a proline-rich linker sharing 10 strictly invariant anchor positions (P-x-L-P-G-ψ-D-F-x-D-P-Q-G) and a conserved aliphatic position (V/M/L).","i":[[176,188,"PELPGVDFADPQG"],[189,201,"PSLPGMDFPDPQG"],[202,214,"PSLPGLDFADPQG"]]}],"s":"MSASKIPLFKMKDLILILCLLEMSFAVPFFPQQSGTPGMASLSLETMRQLGSLQRLNTLSQYSRYGFGKSFNSLWMHGLLPPHSSLPWMRPREHETQQYEYSLPVHPPPLPSQPSLKPQQPGLKPFLQSAAATTNQATALKEALQPPIHLGHLPLQEGELPLVQQQVAPSDKPPKPELPGVDFADPQGPSLPGMDFPDPQGPSLPGLDFADPQGSTIFQIARLISHGPMPQNKQSPLYPGMLYVPFGANQLNAPARLGIMSSEEVAGGREDPMAYGAMFPGFGGMRPGFEGMPHNPAMGGDFTLEFDSPVAATKGPENEEGGAQGSPMPEANPDNLENPAFLTELEPAPHAGLLALPKDDIPGLPRSPSGKMKGLPSVTPAAADPLMTPELADVYRTYDADMTTSVDFQEEATMDTTMAPNSLQTSMPGNKAQEPEMMHDAWHFQEP"},{"id":"SEQ_04033","a":"P07197","g":"NEFM","d":"Neurofilament medium polypeptide","L":916,"m":[{"c":"K[AG]KSPV[PS]KSPVEE","u":13,"sp":"tandem","x":"disordered_like","cf":"high","why":"Six contiguous head-to-tail 13-residue repeats in the C-terminal disordered tail with 11/13 invariant positions pairing K[AG]KSPV[PS] and KSPVEE sub-motifs.","i":[[612,624,"KAKSPVPKSPVEE"],[625,637,"KGKSPVPKSPVEE"],[638,650,"KGKSPVPKSPVEE"],[651,663,"KGKSPVPKSPVEE"],[664,676,"KGKSPVSKSPVEE"],[677,689,"KAKSPVPKSPVEE"]]},{"c":"EEKψV[VS]TK[TK]VEKψTS","u":15,"sp":"dispersed","x":"mixed","cf":"medium","why":"Two non-overlapping 15-residue segments in the distal C-terminal tail sharing 11 identical residues (EEK-x-V-x-TK-x-VEK-x-TS) and two conservative aliphatic substitutions (V/L and I/V).","i":[[849,863,"EEKVVVTKTVEKITS"],[891,905,"EEKLVSTKKVEKVTS"]]}],"s":"MSYTLDSLGNPSAYRRVTETRSSFSRVSGSPSSGFRSQSWSRGSPSTVSSSYKRSMLAPRLAYSSAMLSSAESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD"},{"id":"SEQ_04036","a":"Q2M2I8","g":"AAK1","d":"AP2-associated protein kinase 1","L":961,"m":[{"c":"[ES][SKN]LI[PES]G[FL]","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed 7-residue linear motifs in the C-terminal disordered region anchored by invariant L3, I4, and G6 positions, a C-terminal [FL] hydrophobic choice, and polar/charged N-terminal and internal positions (including near-identical ESLIPGF and ESLIPGL copies).","i":[[733,739,"ESLIPGF"],[789,795,"EKLIEGL"],[830,836,"ESLIPGL"],[898,904,"SNLISGF"]]},{"c":"-xSLL","u":5,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three non-overlapping 5-residue acidic-dileucine motifs in the C-terminal disordered tail (one isolated copy and a head-to-tail tandem pair EDSLLDCSLL) defined by a leading acidic residue and invariant SLL core.","i":[[799,803,"DTSLL"],[862,866,"EDSLL"],[867,871,"DCSLL"]]}],"s":"MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFIPLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL"},{"id":"SEQ_04041","a":"Q9NRL3","g":"STRN4","d":"Striatin-4","L":753,"m":[{"c":"xxxxx[HG](x){3,5}ψxxφ[AFV]φxxxxxxψφxxxxD(x){2,3}φ+φΩx","u":"35-38","sp":"periodic","x":"structured_like","cf":"high","why":"Seven C-terminal structured repeats (35-38 aa) separated by 7-18 aa linkers, anchored by an N-terminal His (6/7 copies), hydrophobic beta-strand cores (ψxxφ[AFV]φ and ψφ), a conserved Asp turn, and a C-terminal φ+φΩx motif (6/7 aromatic W/Y/F).","i":[[432,466,"FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWN"],[485,519,"HAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK"],[538,572,"HVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD"],[585,619,"PTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYD"],[628,665,"TLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLD"],[673,707,"HSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS"],[719,753,"AHRKKHEEAIHAVACHPSKALIASAGADALAKVFV"]]}],"s":"MMEERAAAAVAAAASSCRPLGSGAGPGPTGAAPVSAPAPGPGPAGKGGGGGGSPGPTAGPEPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYHKLKFGTDLNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQYLEEVGYTDTILDMRSKRVRSLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQIEEQIKRNAAGKDGKERLGGSVLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALVPEMEDEDEEDDSEDAINEFDFLGSGEDGEGAPDPRRCTVDGSPHELESRRVKLQGILADLRDVDGLPPKVTGPPPGTPQPRPHEDVFIMDTIGGGEVSLGDLADLTVTNDNDLSCDLSDSKDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV"},{"id":"SEQ_04043","a":"Q8WZ74","g":"CTTNBP2","d":"Cortactin-binding protein 2","L":1663,"m":[{"c":"xx[TS]xφxx[AV][ACV]xx[GD]xxx[CLS]ψxψLψ(x){4,5}xφxxxxxx","u":"33-34","sp":"tandem","x":"structured_like","cf":"high","why":"Seven 33-34 aa structured repeats arranged head-to-tail (with one 34-aa acidic linker between copies 5 and 6), defined by a Gx[TS]xφxxAAxxG turn-helix pattern and an invariant Leu within a [CLS]ψxψLψ hydrophobic second helix.","i":[[710,743,"RPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCED"],[744,776,"GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKN"],[777,809,"GFTPLCAAAAQGHFECVELLISYDANINHAADG"],[810,842,"GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD"],[843,875,"GWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFN"],[913,945,"GWTAAHIAASKGFKNCLEILCRHGGLEPERRDK"],[946,978,"CNRTVHDVATDDCKHLLENLNALKIPLRISVGE"]]},{"c":"[VA][QC]xx[FV][RDK]WφxxxW","u":12,"sp":"periodic","x":"structured_like","cf":"high","why":"Three 12-aa tryptophan-anchored amphipathic segments occurring at exact 43-residue intervals (31-aa linkers), featuring two invariant Trp residues in a WφxxxW spacing flanked by conserved hydrophobic ([VA], [FV]) and charged ([RDK]) positions.","i":[[1261,1272,"VQQHFRWVQLRW"],[1304,1315,"VCKIVDWALSVW"],[1347,1358,"AQVTVKWMSKLW"]]}],"s":"MATDGASCEPDLSRAPEDAAGAAAEAAKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAKLEEEKKKTNELEEELSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTEGTVTRSVACQTDLVTENADHMKKLPLTMPVKPSTGSPLVSANAKGSVCTSATMARPGIDRQASYGDLIGASVPAFPPPSANKIEENGPSTGSTPDPTSSTPPLPSNAAPPTAQTPGIAPQNSQAPPMHSLHSPCANTSLHPGLNPRIQAARFRFQGNANDPDQNGNTTQSPPSRDVSPTSRDNLVAKQLARNTVTQALSRFTSPQAGAPSRPGVPPTGDVGTHPPVGRTSLKTHGVARVDRGNPPPIPPKKPGLSQTPSPPHPQLKVIIDSSRASNTGAKVDNKTVASTPSSLPQGNRVINEENLPKSSSPQLPPKPSIDLTVAPAGCAVSALATSQVGAWPAATPGLNQPACSDSSLVIPTTIAFCSSINPVSASSCRPGASDSLLVTASGWSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPERRDKCNRTVHDVATDDCKHLLENLNALKIPLRISVGEIEPSNYGSDDLECENTICALNIRKQTSWDDFSKAVSQALTNHFQAISSDGWWSLEDVTCNNTTDSNIGLSARSIRSITLGNVPWSVGQSFAQSPWDFMRKNKAEHITVLLSGPQEGCLSSVTYASMIPLQMMQNYLRLVEQYHNVIFHGPEGSLQDYIVHQLALCLKHRQMAAGFSCEIVRAEVDAGFSKEQLLDLFISSACLIPVKQSPSKKKIIIILENLEKSSLSELLRDFLAPLENRSTESPCTFQKGNGLSECYYFHENCFLMGTIAKACLQGSDLLVQQHFRWVQLRWDGEPMQGLLQRFLRRKVVNKFKGQAPSPCDPVCKIVDWALSVWRQLNSCLARLGTPEALLGPKYFLSCPVVPGHAQVTVKWMSKLWNGVIAPRVQEAILSRASVKRQPGFGQTTAKRHPSQGQQAVVKAALSILLNKAVLHGCPLPRAELDQHTADFKGGSFPLSIVSSYNTCNKKKGESGAWRKVNTSPRRKSGRFSLPTWNKPDLSTEGMKNKTISQLNCNRNASLSKQKSLENDLSLTLNLDQRLSLGSDDEADLVKELQSMCSSKSESDISKIADSRDDLRMFDSSGNNPVLSATINNLRMPVSQKEVSPLSSHQTTECSNSKSKTELGVSRVKSFLPVPRSKVTQCSQNTKRSSSSSNTRQIEINNNSKEVNWNLHKNEHLEKPNK"},{"id":"SEQ_04049","a":"Q53LP3","g":"SOWAHC","d":"Ankyrin repeat domain-containing protein SOWAHC","L":525,"m":[{"c":"[GT]G[FY]T[AC]LH[LW]AAxHG[HR]xEψψxψLV(x){6,9}V[DN]I(x){3,4}S","u":"35-39","sp":"tandem","x":"structured_like","cf":"high","why":"Head-to-tail tandem duplication of a 35-39 aa structured repeat strongly anchored by GxT[AC]LH[LW]AAxHG[HR]xEψψxψLV and a C-terminal V[DN]I(x){3,4}S motif separated by a short variable loop.","i":[[301,339,"TGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTS"],[340,374,"GGYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYS"]]}],"s":"MEGPAEWGPEAALGPEAVLRFLAERGGRALHAELVQHFRGALGGEPEQRARARAHFKELVNAVATVRVDPADGAKYVHLKKRFCEGPSEPSGDPPRIQVTAEPEAPDGPAGPEARDRLPDAAAPESLPGQGRELGEGEPPAPAHWPPLSAGARRKNSRRDVQPLPRTPAPGPSEDLELPPHGCEEADRGSSLVGATAQRPARQNLRDLVMGSSPQLKRSVCPGGSSPGSSSGGGRGRGGGDSDSASVASSSAEEESSGGGSVTLDPLEHAWMLSASDGKWDSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYSGKKASQYLSRSIAEEIKNLVGALDEGDGESAAGSGGGRWRLSKVLPSHLITYKLSHALEDGGDHHHHHHSAEGWVGGKAKDPGRKASGSSSGRIKPRLNKIRFRTQIVHTTPSFRDPEQPLEGRGEEGVGEERPVKGHSPFTLRPKSNVFG"},{"id":"SEQ_04050","a":"Q53EL9","g":"SEZ6","d":"Seizure protein 6 homolog","L":994,"m":[{"c":"G[ADT][TV][ITV](x){1,11}[FY]xCxxG[FY]x[LV](x){1,2}Gxxx[IL]xC(x){5,9}WxxxxPxC","u":"35-47","sp":"dispersed","x":"structured_like","cf":"high","why":"Five dispersed ~35-47 aa disulfide-rich structured repeats sharing invariant G, C, G[FY], G, C, and WxxxxPxC anchors alongside conserved aliphatic and aromatic core positions.","i":[[366,412,"GDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVC"],[552,589,"GTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPAC"],[731,765,"GTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSC"],[792,830,"GATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPKC"],[859,895,"GATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPIC"]]},{"c":"C[GS]GxIx(x){6,7}ψSPxΩPxxYxxxx[DT]CxW[GL]ψxxxE[DG][KQ]Rψ[HM]L[DH]φ(x){7,8}[DG]DxL[IT]φx[DN]GD[DN]ψxAxxψxxxxxxxxxxxxxxxxxxxxφxφxxxxxxSx(x){6,8}ψ[HR]Ωxxφ(x){2,3}xxC","u":"117-118","sp":"dispersed","x":"structured_like","cf":"high","why":"Two non-overlapping 117-118 aa structured domain repeats interspersed among the shorter cysteine-rich modules, conserving bounding cysteines, an internal ψSPxΩPxxYxxxx[DT]CxW core, and a [DN]GD[DN] turn.","i":[[416,532,"CGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHC"],[593,710,"CSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTC"]]}],"s":"MRPVALLLLPSLLALLAHGLSLEAPTVGKGQAPGIEETDGELTAAPTPEQPERGVHFVTTAPTLKLLNHHPLLEEFLQEGLEKGDEELRPALPFQPDPPAPFTPSPLPRLANQDSRPVFTSPTPAMAAVPTQPQSKEGPWSPESESPMLRITAPLPPGPSMAVPTLGPGEIASTTPPSRAWTPTQEGPGDMGRPWVAEVVSQGAGIGIQGTITSSTASGDDEETTTTTTIITTTITTVQTPGPCSWNFSGPEGSLDSPTDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGETVTVEGLGGPDPLPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYNSRSLDVAKAPAASSTLDAAHIAAAIFLPLVAMVLLVGGVYFYFSRLQGKSSLQLPRPRPRPYNRITIESAFDNPTYETGSLSFAGDERI"},{"id":"SEQ_04052","a":"Q6ZQX7","g":"LIAT1","d":"Protein LIAT1","L":453,"m":[{"c":"ALKG[FI]H[PTI]DPx","u":10,"sp":"tandem","x":"mixed","cf":"high","why":"20 head-to-tail tandem copies of a highly conserved 10-residue repeat (positions 201-400) with invariant ALKG, H, and DP anchors, hydrophobic [FI] at position 5, predominantly Pro/Thr at position 7, and mostly Glu/Lys at position 10.","i":[[201,210,"ALKGFHPDPE"],[211,220,"ALKGFHPDPD"],[221,230,"ALKGFHPDPE"],[231,240,"ALKGFHPDPE"],[241,250,"ALKGFHPDPE"],[251,260,"ALKGFHPDPE"],[261,270,"ALKGIHPDPE"],[271,280,"ALKGIHPDPE"],[281,290,"ALKGFHPDPE"],[291,300,"ALKGFHPDPE"],[301,310,"ALKGFHTDPE"],[311,320,"ALKGFHIDPE"],[321,330,"ALKGFHPDPK"],[331,340,"ALKGFHPDPK"],[341,350,"ALKGFHTDPE"],[351,360,"ALKGFHPDPK"],[361,370,"ALKGFHPDPE"],[371,380,"ALKGFHPDPE"],[381,390,"ALKGFHPDPE"],[391,400,"ALKGFHTDPN"]]}],"s":"METRGPGLAVRAESRRLVGIGPRAPPGRVGLQPSGRLDRRGGAGTMGYKDNDGEEEEREGGAAGPRGSRLPPITGGASELAKRKVKKKKRKKKTKGSGKGDDKHQSQSLKSQPLSSSFHDILSPCKERGPKPEHRQSKVEKKHLPSDSSTVSLPDFAEIENLANRINESLRWDGILADPEAEKERIRIYKLNRRKRYRCLALKGFHPDPEALKGFHPDPDALKGFHPDPEALKGFHPDPEALKGFHPDPEALKGFHPDPEALKGIHPDPEALKGIHPDPEALKGFHPDPEALKGFHPDPEALKGFHTDPEALKGFHIDPEALKGFHPDPKALKGFHPDPKALKGFHTDPEALKGFHPDPKALKGFHPDPEALKGFHPDPEALKGFHPDPEALKGFHTDPNAEEAPENLPYLSDKDGSSSHRQPTSKAECPNLCFEGNLTPKLLHSDLAPTLLE"},{"id":"SEQ_04076","a":"Q9Y5Q9","g":"GTF3C3","d":"General transcription factor 3C polypeptide 3","L":886,"m":[{"c":"xxxφxxφ[AGS]xxφxxxxxxxx[ASV]φxxYxxφφxxxPxx","u":34,"sp":"dispersed","x":"structured_like","cf":"high","why":"Ten 34-aa structured repeat units organized into N-terminal (4 tandem/near-tandem copies) and C-terminal (5 tandem/near-tandem copies) arrays plus one central copy. Copies share conserved hydrophobic positions (4, 7, 11, 21, and an invariant φφ pair at 27-28), a small [AGS] anchor at position 8, a conserved Y at position 24, and a frequent C-terminal turn P at position 32.","i":[[183,216,"YEPFSTLAMIYEDQGDMEKSLQFELIAAHLNPSD"],[217,250,"TEEWVRLAEMSLEQDNIKQAIFCYTKALKYEPTN"],[251,284,"VRYLWERSSLYEQMGDHKMAMDGYRRILNLLSPS"],[286,319,"GERFMQLARDMAKSYYEANDVTSAINIIDEAFSK"],[456,489,"AVVWLRHAECLKALGYMERAAESYGKVVDLAPLH"],[665,698,"RKELEYFGLSAAILDKNFRKAYNYIRIMVMENVN"],[699,732,"KPQLWNIFNQVTMHSQDVRHHRFCLRLMLKNPEN"],[733,766,"HALCVLNGHNAFVSGSFKHALGQYVQAFRTHPDE"],[767,800,"PLYSFCIGLTFIHMASQKYVLRRHALIVQGFSFL"],[811,844,"QESFYNLGRGLHQLGLIHLAIHYYQKALELPPLV"]]}],"s":"MSGFSPELIDYLEGKISFEEFERRREERKTREKKSLQEKGKLSAEENPDDSEVPSSSGINSTKSQDKDVNEGETSDGVRKSVHKVFASMLGENEDDEEEEEEEEEEEEEEETPEQPTAGDVFVLEMVLNRETKKMMKEKRPRSKLPRALRGLMGEANIRFARGEREEAILMCMEIIRQAPLAYEPFSTLAMIYEDQGDMEKSLQFELIAAHLNPSDTEEWVRLAEMSLEQDNIKQAIFCYTKALKYEPTNVRYLWERSSLYEQMGDHKMAMDGYRRILNLLSPSDGERFMQLARDMAKSYYEANDVTSAINIIDEAFSKHQGLVSMEDVNIAAELYISNKQYDKALEIITDFSGIVLEKKTSEEGTSEENKAPENVTCTIPDGVPIDITVKLMVCLVHLNILEPLNPLLTTLVEQNPEDMGDLYLDVAEAFLDVGEYNSALPLLSALVCSERYNLAVVWLRHAECLKALGYMERAAESYGKVVDLAPLHLDARISLSTLQQQLGQPEKALEALEPMYDPDTLAQDANAAQQELKLLLHRSTLLFSQGKMYGYVDTLLTMLAMLLKVAMNRAQVCLISSSKSGERHLYLIKVSRDKISDSNDQESANCDAKAIFAVLTSVLTKDDWWNLLLKAIYSLCDLSRFQEAELLVDSSLEYYSFYDDRQKRKELEYFGLSAAILDKNFRKAYNYIRIMVMENVNKPQLWNIFNQVTMHSQDVRHHRFCLRLMLKNPENHALCVLNGHNAFVSGSFKHALGQYVQAFRTHPDEPLYSFCIGLTFIHMASQKYVLRRHALIVQGFSFLNRYLSLRGPCQESFYNLGRGLHQLGLIHLAIHYYQKALELPPLVVEGIELDQLDLRRDIAYNLSLIYQSSGNTGMAQTLLYTYCSI"},{"id":"SEQ_04103","a":"Q8WWQ0","g":"PHIP","d":"PH-interacting protein","L":1821,"m":[{"c":"xxxxGH(x){2,3}ψxxxxx(x){4,8}xxφxx[GAT]xx[DNH]xxφxφΩ","u":"33-38","sp":"periodic","x":"structured_like","cf":"high","why":"Eight consecutive ~34 aa structured repeat units (residues 177-541) separated by short linkers (mostly 8-16 aa), featuring an N-terminal GH turn in most copies, a conserved aliphatic residue, a short variable turn (4-8 aa), and a tightly conserved C-terminal xxφxx[GAT]xx[DNH]xxφxφΩ core ending in an aromatic anchor (6 W, 1 Y, 1 F).","i":[[177,210,"KRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIW"],[219,252,"ATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVW"],[261,298,"AVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFW"],[315,348,"TERPRPGVQMICSSFSAGGMFLATGSTDHIIRVY"],[359,392,"SELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIW"],[418,451,"IEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVW"],[460,494,"HVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVW"],[509,541,"IEGQGHGAVFDCKCSPDGQHFACTDSHGHLLIF"]]},{"c":"[KH]xxxGRKPK","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 9-aa copies within the C-terminal polar/basic disordered region (residues 1636-1717) sharing an invariant GRKPK pentapeptide core preceded by a basic/Gly/Pro-enriched 4-residue flank anchored by [KH] at position 1.","i":[[1636,1644,"KRGPGRKPK"],[1656,1664,"HKKRGRKPK"],[1709,1717,"KNRGGRKPK"]]}],"s":"MSCERKGLSELRSELYFLIARFLEDGPCQQAAQVLIREVAEKELLPRRTDWTGKEHPRTYQNLVKYYRHLAPDHLLQICHRLGPLLEQEIPQSVPGVQTLLGAGRQSLLRTNKSCKHVVWKGSALAALHCGRPPESPVNYGSPPSIADTLFSRKLNGKYRLERLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLLIFGFGSSSKYDKIADQMFFHSDYRPLIRDANNFVLDEQTQQAPHLMPPPFLVDVDGNPHPSRYQRLVPGRENCREEQLIPQMGVTSSGLNQVLSQQANQEISPLDSMIQRLQQEQDLRRSGEAVISNTSRLSRGSISSTSEVHSPPNVGLRRSGQIEGVRQMHSNAPRSEIATERDLVAWSRRVVVPELSAGVASRQEEWRTAKGEEEIKTYRSEEKRKHLTVPKENKIPTVSKNHAHEHFLDLGESKKQQTNQHNYRTRSALEETPRPSEEIENGSSSSDEGEVVAVSGGTSEEEERAWHSDGSSSDYSSDYSDWTADAGINLQPPKKVPKNKTKKAESSSDEEEESEKQKQKQIKKEKKKVNEEKDGPISPKKKKPKERKQKRLAVGELTENGLTLEEWLPSTWITDTIPRRCPFVPQMGDEVYYFRQGHEAYVEMARKNKIYSINPKKQPWHKMELREQELMKIVGIKYEVGLPTLCCLKLAFLDPDTGKLTGGSFTMKYHDMPDVIDFLVLRQQFDDAKYRRWNIGDRFRSVIDDAWWFGTIESQEPLQLEYPDSLFQCYNVCWDNGDTEKMSPWDMELIPNNAVFPEELGTSVPLTDGECRSLIYKPLDGEWGTNPRDEECERIVAGINQLMTLDIASAFVAPVDLQAYPMYCTVVAYPTDLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRTFNEPGSPIVKSAKFVTDLLLHFIKDQTCYNIIPLYNSMKKKVLSDSEDEEKDADVPGTSTRKRKDHQPRRRLRNRAQSYDIQAWKKQCEELLNLIFQCEDSEPFRQPVDLLEYPDYRDIIDTPMDFATVRETLEAGNYESPMELCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSAFFEEHISSVLSDYKSALRFHKRNTITKRRKKRNRSSSVSSSAASSPERKKRILKPQLKSESSTSAFSTPTRSIPPRHNAAQINGKTESSSVVRTRSNRVVVDPVVTEQPSTSSAAKTFITKANASAIPGKTILENSVKHSKALNTLSSPGQSSFSHGTRNNSAKENMEKEKPVKRKMKSSVLPKASTLSKSSAVIEQGDCKNNALVPGTIQVNGHGGQPSKLVKRGPGRKPKVEVNTNSGEIIHKKRGRKPKKLQYAKPEDLEQNNVHPIRDEVLPSSTCNFLSETNNVKEDLLQKKNRGGRKPKRKMKTQKLDADLLVPASVKVLRRSNRKKIDDPIDEEEEFEELKGSEPHMRTRNQGRRTAFYNEDDSEEEQRQLLFEDTSLTFGTSSRGRVRKLTEKAKANLIGW"},{"id":"SEQ_04130","a":"Q96T92","g":"INSM2","d":"Insulinoma-associated protein 2","L":566,"m":[{"c":"[FY]xCxxCxxx[FY]xxxxx[LR]xxH(x){3,4}[HR]","u":"23-24","sp":"dispersed","x":"structured_like","cf":"high","why":"Five dispersed 23-24 aa structured repeats anchored by invariant CxxC and H residues, strictly conserved aromatics ([FY]) at positions 1 and 10, and [LR] at position 16, with a 3-4 residue spacer before the terminal [HR] position.","i":[[263,285,"FICQLCKEQYADPFALAQHRCSR"],[291,313,"YRCPECDKVFSCPANLASHRRWH"],[426,448,"FVCPYCHKKFRRQAYLRKHLSTH"],[470,492,"FACPLCGAHFPTADIREKHRLWH"],[525,548,"FSCKHCPSTFFSSPGLTRHINKCH"]]}],"s":"MPRGFLVKRTKRTGGLYRVRLAERVFPLLGPQGAPPFLEEAPSASLPGAERATPPTREEPGKGLTAEAAREQSGSPCRAAGVSPGTGGREGAEWRAGGREGPGPSPSPSPSPAKPAGAELRRAFLERCLSSPVSAESFPGGAAAVAAFSCSVAPAAAPTPGEQFLLPLRAPFPEPALQPDPAPLSAALQSLKRAAGGERRGKAPTDCASGPAAAGIKKPKAMRKLSFADEVTTSPVLGLKIKEEEPGAPSRGLGGSRTPLGEFICQLCKEQYADPFALAQHRCSRIVRVEYRCPECDKVFSCPANLASHRRWHKPRPAAANAATVSSADGKPPSSSSSSSRDSGAIASFLAEGKENSRIERTADQHPQARDSSGADQHPDSAPRQGLQVLTHPEPPLPQGPYTEGVLGRRVPVPGSTSGGRGSEIFVCPYCHKKFRRQAYLRKHLSTHEAGSARALAPGFGSERGAPLAFACPLCGAHFPTADIREKHRLWHAVREELLLPALAGAPPETSGPSGPSDGSAQQIFSCKHCPSTFFSSPGLTRHINKCHPSESRQVLLLQMPLRPGC"},{"id":"SEQ_04162","a":"Q6ZMV5","g":"PPP4R3C","d":"Protein PPP4R3C","L":832,"m":[{"c":"[DQ][AE]GE[AV]VMPPLEDDD[EK]F[MT]ETKR[NT]","u":22,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three highly conserved 22-aa tandem repeats (separated by 0 and 1 aa) in the acidic/proline-rich C-terminal disordered region, sharing 16 invariant anchor positions around a core GExVMPPLEDDDxFxETKRx motif.","i":[[688,709,"DAGEVVMPPLEDDDEFMETKRT"],[710,731,"QEGEAVMPPLEDDDKFTETKRT"],[733,754,"QEGEAVMPPLEDDDEFMETKRN"]]}],"s":"MAGLRYSVKVYVLNEDEEWNNLGTGQVSSTYDEQFQGMSLLVRSDSDGSVILRSQIPPDRPYGKYQETLIVWYEAENQGLVLKFQDPAGCQDIWKEICQAQGKDPSIQTTVNISDEPEEDFNEMSVISNMVVLPDCELNTLDQIADIVTSVFSSPVTDRERLAEILKNEAYIPKLLQLFHTCENLENTEGLHHLYEIIKGILFLNEACLFEIMFSDECIMDVVGCLEYDPALDQPKRHRDFLTNDAKFKEVIPITNSELRQKIHQTYRLQYIYDILLPVPSIFEDNFLSTLTTFIFSNKAEIVSMLQKDHKFLYEVFAQLKDETTHDDRRCELLFFFKELCSFSQALQPQSKDALFETLIQLGVLPALKIVMIRDDLQVRSAAAVICAYLVEYSPSRIREFIISEAHVCKDSDLFINVIIKQMICDTDPELGGAVHLMVVLHTLLDPRNMLTTPEKSERSEFLHFFYKHCMHKFTAPLLAATSEHNCEEDDIAGYDKSKNCPNDNQTAQLLALILELLTFCIQHHTFYIRSYILNKDLLRKALILMNSKHTHLILCVLRFMRRMICLNDEAYNNYIIKGNLFEPVVNALLDNGTRYNMLNSAILELFEYIRVENIKPLVSHIVEKFYNTLESIEYVQTFKGLKIKYEKERDRQSQIQKNLHSVLQNIVVFRGTIEEIGLEEEICFMEDAGEVVMPPLEDDDEFMETKRTQEGEAVMPPLEDDDKFTETKRTHQEGEAVMPPLEDDDEFMETKRNQEHEGKVDSPKRTSSGDFKFSSSYSACAAIGTGSPSGSSVVRLVDHPDDEEEKEEDEEEKEEDKEDETSPKKKPHLSS"},{"id":"SEQ_04179","a":"Q9NT68","g":"TENM2","d":"Teneurin-2","L":2774,"m":[{"c":"C(x){3,4}Cxx[HN]Gx[CY](x){4,8}CxCxx[GN]ΩxGxxC","u":"27-31","sp":"periodic","x":"structured_like","cf":"high","why":"Eight periodic disulfide-knotted repeats (residues 577-840) separated by short 4-13 aa linkers, anchored by five invariant cysteines (including a fixed CxC dyad), conserved [HN]G and GxC motifs, and an invariant aromatic residue in the C-terminal [GN]ΩxGxxC segment.","i":[[576,602,"CPRNCHGNGECVSGVCHCFPGFLGADC"],[607,633,"CPVLCSGNGQYSKGTCQCYSGWKGAEC"],[640,667,"CIDPSCGGHGSCIDGNCVCSAGYKGEHC"],[672,699,"CLDPTCSSHGVCVNGECLCSPGWGGLNC"],[706,734,"CPDQCSGHGTYLPDTGLCSCDPNWMGPDC"],[739,765,"CSVDCGTHGVCIGGACRCEEGWTGAAC"],[770,796,"CHPRCIEHGTCKDGKCECREGWNGEHC"],[810,840,"CPDLCNGNGRCTLGQNSWQCVCQTGWRGPGC"]]},{"c":"x[LI]A[VI](x){3,4}[GN]xψYφx[DE](x){4,5}+[IV]","u":"20-22","sp":"periodic","x":"structured_like","cf":"high","why":"Six periodic beta-propeller-like blade repeats (residues 1243-1563) spaced by 27-45 aa linkers, defined by an N-terminal [LI]A[VI] hydrophobic strand, a turn ending in [GN], an invariant tyrosine within a ψYφx[DE] core, and a C-terminal +[IV] dyad.","i":[[1242,1262,"ALAVGIDGSLYVGDFNYIRRI"],[1290,1310,"YLAVDPVSGSLYVSDTNSRRI"],[1360,1380,"GIAVDKNGLMYFVDATMIRKV"],[1419,1440,"DLAVNPMDNSLYVLENNVILRI"],[1479,1498,"AIAISHTGVLYITETDEKKI"],[1548,1567,"SLAVAPDGTIYIADLGNIRI"]]},{"c":"φxY[DS]xx[GD]xψ","u":9,"sp":"dispersed","x":"structured_like","cf":"high","why":"Eight copies of a conserved 9-residue YD-type beta-shell repeat motif distributed across residues 1704-2354 (with a periodic ~21-22 aa cluster in 2177-2254), anchored by an invariant Tyr followed by [DS], a [GD] turn position, and flanking hydrophobic/aliphatic positions.","i":[[1702,1710,"YDYDHEGRL"],[1953,1961,"FEYDSSDRL"],[1998,2006,"FDYSDDGRI"],[2177,2185,"VQYDSMGRV"],[2203,2211,"YDYDGDGQL"],[2224,2232,"YSYDLNGNL"],[2246,2254,"LRYDLRDRI"],[2346,2354,"LYYDLQGHL"]]}],"s":"MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRESDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNRNSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIAMHLLGLNWQLQPADGHTFNNGIRTGLPGNDDVATMPSGGKVPWSLKNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIGRQTAGTETDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERTVWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPETQVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLAYTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNVKSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFNYIRRIFPSRNVTSILELRNKEFKHSNNPAHKYYLAVDPVSGSLYVSDTNSRRIYRVKSLSGTKDLAGNSEVVAGTGEQCLPFDEARCGDGGKAIDATLMSPRGIAVDKNGLMYFVDATMIRKVDQNGIISTLLGSNDLTAVRPLSCDSSMDVAQVRLEWPTDLAVNPMDNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGIDYSLSKLAIHSALESASAIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCNCYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQELYVFNADGIHQYTVSLVTGEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKVVSTQNLELGLMTYDGNTGLLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQLCNNGTLRVMYANGMGISFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADGKVWSYSYLDKSMVLLLQSQRQYIFEYDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTSFLGTGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVDKQIYRFSEEGMVNARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMTLSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDLRDRITRLGDVQYKIDDDGYLCQRGSDIFEYNSKGLLTRAYNKASGWSVQYRYDGVGRRASYKTNLGHHLQYFYSDLHNPTRITHVYNHSNSEITSLYYDLQGHLFAMESSSGEEYYVASDNTGTPLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDYTMWKNVGKEPAPFNLYMFKSNNPLSSELDLKNYVTDVKSWLVMFGFQLSNIIPGFPRAKMYFVPPPYELSESQASENGQLITGVQQTTERHNQAFMALEGQVITKKLHASIREKAGHWFATTTPIIGKGIMFAIKEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSIEGKDTHYFVKIGSADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYSTLLLSIRYGLTPDTLDEEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLRQNEMGKR"},{"id":"SEQ_04191","a":"Q9H6Z4","g":"RANBP3","d":"Ran-binding protein 3","L":567,"m":[{"c":"A[ST]o[QN]xFVFGQNψx-RV","u":16,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Two strongly conserved 16-aa dispersed copies in the central disordered region share nine identical anchor residues (A, FVFGQN, RV) and five conserved polar, aliphatic, and acidic positions (an additional unaligned FVF tripeptide also occurs near the N-terminus at PPVFVFQK).","i":[[255,270,"ATQQAFVFGQNLRDRV"],[316,331,"ASSNKFVFGQNMSERV"]]}],"s":"MADLANEEKPAIAPPVFVFQKDKGQKSPAEQKNLSDSGEEPRGEAEAPHHGTGHPESAGEHALEPPAPAGASASTPPPPAPEAQLPPFPRELAGRSAGGSSPEGGEDSDREDGNYCPPVKRERTSSLTQFPPSQSEERSSGFRLKPPTLIHGQAPSAGLPSQKPKEQQRSVLRPAVLQAPQPKALSQTVPSSGTNGVSLPADCTGAVPAASPDTAAWRSPSEAADEVCALEEKEPQKNESSNASEEEACEKKDPATQQAFVFGQNLRDRVKLINESVDEADMENAGHPSADTPTATNYFLQYISSSLENSTNSADASSNKFVFGQNMSERVLSPPKLNEVSSDANRENAAAESGSESSSQEATPEKESLAESAAAYTKATARKCLLEKVEVITGEEAESNVLQMQCKLFVFDKTSQSWVERGRGLLRLNDMASTDDGTLQSRLVMRTQGSLRLILNTKLWAQMQIDKASEKSIRITAMDTEDQGVKVFLISASSKDTGQLYAALHHRILALRSRVEQEQEAKMPAPEPGAAPSNEEDDSDDDDVLAPSGATAAGAGDEGDGQTTGST"},{"id":"SEQ_04193","a":"P54132","g":"BLM","d":"RecQ-like DNA helicase BLM","L":1417,"m":[{"c":"[IM][DN][DN][FW]D","u":5,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Four non-overlapping 5-aa acidic-hydrophobic-aromatic motifs occur as two dispersed tandem pairs (at residues 151-161 and 553-562) within the polar/proline-rich N-terminal disordered region, anchored by conserved Ile/Met at position 1, Phe/Trp at position 4, and invariant C-terminal Asp.","i":[[151,155,"INDWD"],[157,161,"MDDFD"],[553,557,"IDNFD"],[558,562,"IDDFD"]]}],"s":"MAAVPQNNLQEQLERHSARTLNNKLSLSKPKFSGFTFKKKTSSDNNVSVTNVSVAKTPVLRNKDVNVTEDFSFSEPLPNTTNQQRVKDFFKNAPAGQETQRGGSKSLLPDFLQTPKEVVCTTQNTPTVKKSRDTALKKLEFSSSPDSLSTINDWDDMDDFDTSETSKSFVTPPQSHFVRVSTAQKSKKGKRNFFKAQLYTTNTVKTDLPPPSSESEQIDLTEEQKDDSEWLSSDVICIDDGPIAEVHINEDAQESDSLKTHLEDERDNSEKKKNLEEAELHSTEKVPCIEFDDDDYDTDFVPPSPEEIISASSSSSKCLSTLKDLDTSDRKEDVLSTSKDLLSKPEKMSMQELNPETSTDCDARQISLQQQLIHVMEHICKLIDTIPDDKLKLLDCGNELLQQRNIRRKLLTEVDFNKSDASLLGSLWRYRPDSLDGPMEGDSCPTGNSMKELNFSHLPSNSVSPGDCLLTTTLGKTGFSATRKNLFERPLFNTHLQKSFVSSNWAETPRLGKKNESSYFPGNVLTSTAVKDQNKHTASINDLERETQPSYDIDNFDIDDFDDDDDWEDIMHNLAASKSSTAAYQPIKEGRPIKSVSERLSSAKTDCLPVSSTAQNINFSESIQNYTDKSAQNLASRNLKHERFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAGRDGEISHCLLFYTYHDVTRLKRLIMMEKDGNHHTRETHFNNLYSMVHYCENITECRRIQLLAYFGENGFNPDFCKKHPDVSCDNCCKTKDYKTRDVTDDVKSIVRFVQEHSSSQGMRNIKHVGPSGRFTMNMLVDIFLGSKSAKIQSGIFGKGSAYSRHNAERLFKKLILDKILDEDLYINANDQAIAYVMLGNKAQTVLNGNLKVDFMETENSSSVKKQKALVAKVSQREEMVKKCLGELTEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVISVLQKYSEWTSPAEDSSPGISLSSSRGPGRSAAEELDEEIPVSSHYFASKTRNERKRKKMPASQRSKRRKTASSGSKAKGGSATCRKISSKTKSSSIIGSSSASHTSQATSGANSKLGIMAPPKPINRPFLKPSYAFS"},{"id":"SEQ_04195","a":"Q53GI3","g":"ZNF394","d":"Zinc finger protein 394","L":561,"m":[{"c":"xx-+[PH][YF]xCxxC[GE][KE][SRT][FC](x){2,3}[SAT]xLx+H[QH][RS][ITL]H","u":"27-28","sp":"tandem","x":"structured_like","cf":"high","why":"Seven head-to-tail C-terminal repeats anchored by an N-terminal -+[PH][YF] linker, invariant CxxC pair, conserved core L, and C-terminal +HxxH motif, with a 1-residue shorter loop in the fourth unit (27 vs 28 aa).","i":[[353,380,"HEERPYKCGNCGKSFKQRSDLFRHQRIH"],[381,408,"TGEKPYGCQECGKSFSQSAALTKHQRTH"],[409,436,"TGEKPYTCLKCGERFRQNSHLNRHQSTH"],[437,463,"SRDKHFKCEECGETCHISNLFRHQRLH"],[464,491,"KGERPYKCEECEKSFKQRSDLFKHHRIH"],[492,519,"TGEKPYGCSVCGKRFNQSATLIKHQRIH"],[520,547,"TGEKPYKCLECGERFRQSTHLIRHQRIH"]]}],"s":"MNSSLTAQRRGSDAELGPWVMAARSKDAAPSQRDGLLPVKVEEDSPGSWEPNYPAASPDPETSRLHFRQLRYQEVAGPEEALSRLRELCRRWLRPELLSKEQILELLVLEQFLTILPEELQAWVREHCPESGEEAVAVVRALQRALDGTSSQGMVTFEDTAVSLTWEEWERLDPARRDFCRESAQKDSGSTVPPSLESRVENKELIPMQQILEEAEPQGQLQEAFQGKRPLFSKCGSTHEDRVEKQSGDPLPLKLENSPEAEGLNSISDVNKNGSIEGEDSKNNELQNSARCSNLVLCQHIPKAERPTDSEEHGNKCKQSFHMVTWHVLKPHKSDSGDSFHHSSLFETQRQLHEERPYKCGNCGKSFKQRSDLFRHQRIHTGEKPYGCQECGKSFSQSAALTKHQRTHTGEKPYTCLKCGERFRQNSHLNRHQSTHSRDKHFKCEECGETCHISNLFRHQRLHKGERPYKCEECEKSFKQRSDLFKHHRIHTGEKPYGCSVCGKRFNQSATLIKHQRIHTGEKPYKCLECGERFRQSTHLIRHQRIHQNKVLSAGRGGSRL"},{"id":"SEQ_04216","a":"Q86VR2","g":"RETREG3","d":"Reticulophagy regulator 3","L":466,"m":[{"c":"HSD[SAP]E[EV][ES]","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 7-residue acidic motifs in the C-terminal disordered region (separated by 22 and 25 aa linkers) sharing an invariant HSD anchor and conserved +5 Glu followed by [EV][ES].","i":[[257,263,"HSDSEEE"],[287,293,"HSDAEVS"],[319,325,"HSDPEES"]]}],"s":"MAEAEGVPTTPGPASGSTFRGRRDVSGSWERDQQVEAAQRALVEVLGPYEPLLSRVQAALVWERPARSALWCLGLNAAFWFFALTSLRLVFLLAFGLMIIVCIDQWKNKIWPEIKVPRPDALDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNVLLFKKQNPGKFCLLSCGILTFLAVLGRYVPGLLLSYLMLVTVMMWPLAVYHRLWDRAYVRLKPALQRLDFSVRGYMMSKQRERQLRRRALHPERAMDNHSDSEEELAAFCPQLDDSTVARELAITDSEHSDAEVSCTDNGTFNLSRGQTPLTEGSEDLDGHSDPEESFARDLPDFPSINMDPAGLDDEDDTSIGMPSLMYRSPPGAEEPQAPPASRDEAALPELLLGALPVGSNLTSNLASLVSQGMIQLALSGASQPGPSGAPAQRATRGFLRSPSSDLDTDAEGDDFELLDQSELSQLDPASSRSH"},{"id":"SEQ_04226","a":"A8MWX3","g":"WASH4P","d":"Putative WAS protein family homolog 4","L":477,"m":[{"c":"[YT]ψ[PA]-L[GP]","u":6,"sp":"periodic","x":"disordered_like","cf":"high","why":"Four periodic 6-residue repeats separated by 7-9 aa linkers in a proline/acidic-rich disordered region share a tightly constrained [YT]ψ[PA]-L[GP] motif; the first three copies preserve a stricter Yψ[PA]DL[GP] tyrosine-anchored core while the fourth copy (TIPELP) maintains the ψ[PA]-L[GP] register at the same ~15-residue period.","i":[[247,252,"YVPDLG"],[262,267,"YLPDLP"],[275,280,"YIADLG"],[290,295,"TIPELP"]]}],"s":"MSGVMCLKASDTWASGIRSQPQGCLGKWRSMRCKHTRMHLAHLGNSRQLISLGPPRTREDGSRISQQVEQSRSQVQAIGEKVSLAQAKIEKIKGSKKAIKVFSSAKYPAPERLQEYGSIFTDAQDPGLQRRPRHRIQSKQRPLDERALQEKLKDFPVCVSTKPEPEDDAEEGLGGLPSNISSVSSLLLFNTTENLYKKYVFLDPLAGAVTKTHVMLGAETEEKLFDAPLSISKREQLEQQVPENYFYVPDLGQVPEIDVPSYLPDLPGIANDLMYIADLGPGIAPSAPGTIPELPTFHTEVAEPLKVDLQDGVLTPPPPPPPPPPAPEVLASAPPLPPSTAAPVGQGARQDDSSSSASPSVQGAPREVVDPSGGWATLLESIRQAGGIGKAKLRSMKERKLEKQQQKEQEQVRATSQGGHLMSDLFNKLVMRRKGISGKGPGAGDGPGGAFARVSDSIPPLPPPQQPQAEDEDDWES"},{"id":"SEQ_04229","a":"Q9GZU2","g":"PEG3","d":"Paternally-expressed gene 3 protein","L":1588,"m":[{"c":"φxCxxCxxxFxxxxx[LF]xxHxxxH","u":23,"sp":"dispersed","x":"structured_like","cf":"high","why":"Twelve dispersed 23-aa C2H2-type repeats distributed across residues 455-1586 with invariant C3, C6, F10, H19, and H23 anchors plus conserved hydrophobic positions 1 (φ) and 16 ([LF]).","i":[[452,474,"YVCDECGRSFSVISEFVEHQIMH"],[505,527,"FECKDCGETFNKSAALAEHRKIH"],[563,585,"YECRVCKETFLHSSALIEHQKIH"],[627,649,"YECKVCGETFLHSSSLKEHQKIH"],[969,991,"YECQECGECFAHSSDLTEHQKIH"],[1107,1129,"YECEDCGLGFVDLTDLTDHQKVH"],[1163,1185,"YECPKCGESFIHSSFLFEHQRIH"],[1225,1247,"IRCLLCGQGFIHSSALNEHMRLH"],[1282,1304,"FECAVCGESFVNPAELADHVTVH"],[1332,1354,"YECKDCGKSFIHSTVLTKHKELH"],[1505,1527,"YDCHECTETFTSSTAFSEHLKTH"],[1564,1586,"FKCDVCGQLFNDRLSLARHQNTH"]]},{"c":"xxx[AI]xxP","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Fourteen tandem 7-aa acidic-proline repeats across residues 1391-1490 (head-to-tail except two single-residue D insertions) anchored by invariant C-terminal P, conserved position 4 ([AI], 12/14 A), and strong acidic/polar enrichment.","i":[[1391,1397,"NVEAAEP"],[1398,1404,"EVEAAEP"],[1405,1411,"EVEAAEP"],[1412,1418,"EVEAAEP"],[1419,1425,"NGEAEGP"],[1426,1432,"DGEAAEP"],[1433,1439,"IGEAGQP"],[1440,1446,"NGEAEQP"],[1447,1453,"NGDADEP"],[1455,1461,"GAGIEDP"],[1462,1468,"EERAEEP"],[1469,1475,"EGKAEEP"],[1476,1482,"EGDADEP"],[1484,1490,"GVGIEDP"]]},{"c":"+x[YN][EST]xSVI[HQR][ST]","u":10,"sp":"dispersed","x":"mixed","cf":"high","why":"Seven non-overlapping dispersed 10-aa repeats in the central region (residues 716-1147, interleaved between intact C2H2 copies) featuring an invariant SVI core flanked by conserved N-terminal +x[YN][EST] and C-terminal [HQR][ST] positions.","i":[[716,725,"RGYEKSVIHS"],[772,781,"KSYERSVIHS"],[828,837,"REYSRSVIHS"],[889,898,"RNYEDSVIQS"],[945,954,"RSNETSVIHS"],[1000,1009,"RNYEWSVIRS"],[1138,1147,"REYTHSVIHT"]]}],"s":"MLPPKHLSATKPKKSWAPNLYELDSDLTKEPDVIIGEGPTDSEFFHQRFRNLIYVEFVGPRKTLIKLRNLCLDWLQPETRTKEEIIELLVLEQYLTIIPEKLKPWVRAKKPENCEKLVTLLENYKEMYQPEDDNNSDVTSDDDMTRNRRESSPPHSVHSFSDRDWDRRGRSRDMEPRDRWSHTRNPRSRMPPRDLSLPVVAKTSFEMDREDDRDSRAYESRSQDAESYQNVVDLAEDRKPHNTIQDNMENYRKLLSLVQLAEDDGHSHMTQGHSSRSKRSAYPSTSRGLKTMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSDRSQRFPRMSDDNWKDISLNKRESVIQQRVYEGNAFRGGFRFNSTLVSRKRVLERKRRYHFDTDGKGSIHDQKGCPRKKPFECGSEMRKAMSVSSLSSLSSPSFTESQPIDFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEYGESFIHSVAVSEVQKSQVGGKRFECKDCGETFNKSAALAEHRKIHARGYLVECKNQECEEAFMPSPTFSELQKIYGKDKFYECRVCKETFLHSSALIEHQKIHFGDDKDNEREHERERERERGETFRPSPALNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPGQSLKRRQKTYNKEKLCDFTDGRDAFMQSSELSEHQKIHSRKNLFEGRGYEKSVIHSGPFTESQKSHTITRPLESDEDEKAFTISSNPYENQKIPTKENVYEAKSYERSVIHSLASVEAQKSHSVAGPSKPKVMAESTIQSFDAINHQRVRAGGNTSEGREYSRSVIHSLVASKPPRSHNGNELVESNEKGESSIYISDLNDKRQKIPARENPCEGGSKNRNYEDSVIQSVFRAKPQKSVPGEGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHRSNETSVIHSLPFGEQTFRPRGMLYECQECGECFAHSSDLTEHQKIHDREKPSGSRNYEWSVIRSLAPTDPQTSYAQEQYAKEQARNKCKDFRQFFATSEDLNTNQKIYDQEKSHGEESQGENTDGEETHSEETHGQETIEDPVIQGSDMEDPQKDDPDDKIYECEDCGLGFVDLTDLTDHQKVHSRKCLVDSREYTHSVIHTHSISEYQRDYTGEQLYECPKCGESFIHSSFLFEHQRIHEQDQLYSMKGCDDGFIALLPMKPRRNRAAERNPALAGSAIRCLLCGQGFIHSSALNEHMRLHREDDLLEQSQMAEEAIIPGLALTEFQRSQTEERLFECAVCGESFVNPAELADHVTVHKNEPYEYGSSYTHTSFLTEPLKGAIPFYECKDCGKSFIHSTVLTKHKELHLEEEEEDEAAAAAAAAAQEVEANVHVPQVVLRIQGLNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAEGPDGEAAEPIGEAGQPNGEAEQPNGDADEPDGAGIEDPEERAEEPEGKAEEPEGDADEPDGVGIEDPEEGEDQEIQVEEPYYDCHECTETFTSSTAFSEHLKTHASMIIFEPANAFGECSGYIERASTSTGGANQADEKYFKCDVCGQLFNDRLSLARHQNTHTG"},{"id":"SEQ_04230","a":"A0A1B0GTU1","g":"ZC3H11B","d":"Zinc finger CCCH domain-containing protein 11B","L":805,"m":[{"c":"[EG]xxC[YT]φ(x){5,6}C(x){4,5}CxF[RH]H","u":"21-22","sp":"periodic","x":"structured_like","cf":"high","why":"Three N-terminal 21-22 aa CCCH-type repeats separated by regular 7-8 aa linkers, defined by invariant C-C-C-H spacing, a conserved C-terminal CxF[RH]H motif, and N-terminal [EG] and C[YT]φ anchors.","i":[[5,26,"GEDCYFFFYSTCTKGDSCPFRH"],[34,54,"ETVCTLWQEGRCFRRVCRFRH"],[63,84,"EIPCYWENQPTGCQKLNCVFHH"]]},{"c":"ψKT[LV]EE[IM][KL]","u":8,"sp":"dispersed","x":"mixed","cf":"medium","why":"Three dispersed 8-aa repeats (residues 212-477, each preceded by a [GQ]E..H segment) sharing invariant K2, T3, E5, E6 anchors and tightly conserved aliphatic/basic flanking positions.","i":[[214,221,"IKTLEEIK"],[358,365,"VKTLEEML"],[471,478,"MKTVEEIK"]]}],"s":"MPNQGEDCYFFFYSTCTKGDSCPFRHCEAALGNETVCTLWQEGRCFRRVCRFRHMEIDKKRSEIPCYWENQPTGCQKLNCVFHHNRGRYVDGLFLPPSKSVLPTVPESPEEEVKASQLSVQQNKLSVQSNTSPQLRSVMKVESSENVPSPKHPPVVINAADDDEDDDDQFSEEGDETKTPTLQPTPEVHNGLRVTSVRKPAVNIKQGECLHFGIKTLEEIKSKKMKEKSEEQGEGSSGVSSLLLHPEPVPGPEKENVRTVVRTVTLSTKQGEEPLVRLGLTETLGKRKFSTGGDSDPPLKRSLAQRLGKKVEAPETNTDETPKKAQVSKSLKERLGMSADPNNEDATDKVNKVGEIHVKTLEEMLLERASQKHGESQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEEEHRQQEAERQKSKKDTTCIKLKTDSEIKKTVVLPPIVASKGQSEEPAGKTKSMQEVHMKTVEEIKLEKALRVQQSSESSTSSPSQHEATPGARLLLRITKRTWRKEEKKLQEGNEVDFLSRVRMEATEASVETTGVDITKIQVKRCEIMRETRMQKQQEREKSVLTPLQGDVASCNTQVAEKPVLTAVPGITWHLTKQLPTKSSQKVEVETSGIADSLLNVKWSAQTLEKRGEAKPTVNVKQSVVKVVSSPKLAPKRKAVEMHPAVTAAVKPLSSSSVLQEPPAKKAAVDAVVLLDSEDKSVTVPEAENPRDSLVLPPTQSSSDSSPPEVSGPSSSQMSMKTRRLSSASTGKPPLSVEDDFEKLTWEISGGKLEAEIDLDPGKDEDDLPLEL"},{"id":"SEQ_04235","a":"O43379","g":"WDR62","d":"WD repeat-containing protein 62","L":1518,"m":[{"c":"xxxxxφxxφxx(x){4,15}φφxxxx(x){2,6}ψxφΩx","u":"30-40","sp":"periodic","x":"structured_like","cf":"high","why":"Thirteen structured 30-40 aa beta-strand-like repeat units in the N-terminal half (residues 109-743) share conserved hydrophobic beta-strand cores (φφxxxx) followed by a short polar/acidic turn and a C-terminal ψxφΩx motif (often ending in W/F/Y plus D/N/Q/H). Most units are separated by regular ~9-16 aa linkers organized into two arrays separated by a 49 aa linker.","i":[[109,141,"TARKSLSALAFSPDGKYIVTGENGHRPAVRIWD"],[153,185,"GHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWD"],[196,225,"KVSCRVIALSFSEDSSYFVTVGNRHVRFWF"],[250,282,"LHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFN"],[292,321,"NLKVSLSSCLCVSQELIFCGCTDGIVRIFQ"],[357,387,"AVYPDTVALTFDPIHQWLSCVYKDHSIYIWD"],[402,441,"FHSSYVWNVEVYPEFEDQRACLPSGSFLTCSSDNTIRFWN"],[491,520,"VKAGVRVMQVSPDGQHLASGDRSGNLRIHE"],[532,564,"AHDAEVLCLEYSKPETGLTLLASASRDRLIHVL"],[578,608,"DHSSSITAIKFAGNRDIQMISCGADKSIYFR"],[625,656,"VAEKTTLYDMDIDITQKYVAVACQDRNVRVYN"],[672,701,"DEGSLLKVHVDPSGTFLATSCSDKSISVID"],[713,743,"GHSEIITSMKFTYDCHHLITVSGDSCVFIWH"]]}],"s":"MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSCLCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPSFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVEVYPEFEDQRACLPSGSFLTCSSDNTIRFWNLDSSPDSHWQKNIFSNTLLKVVYVENDIQHLQDMSHFPDRGSENGTPMDVKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAGNRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWHLGPEITNCMKQHLLEIDHRQQQQHTNDKKRSGHPRQDTYVSTPSEIHSLSPGEQTEDDLEEECEPEEMLKTPSKDSLDPDPRCLLTNGKLPLWAKRLLGDDDVADGLAFHAKRSYQPHGRWAERAGQEPLKTILDAQDLDCYFTPMKPESLENSILDSLEPQSLASLLSESESPQEAGRGHPSFLPQQKESSEASELILYSLEAEVTVTGTDSQYCRKEVEAGPGDQQGDSYLRVSSDSPKDQSPPEDSGESEADLECSFAAIHSPAPPPDPAPRFATSLPHFPGCAGPTEDELSLPEGPSVPSSSLPQTPEQEKFLRHHFETLTESPCRALGDVEASEAEDHFFNPRLSISTQFLSSLQKASRFTHTFPPRATQCLVKSPEVKLMDRGGSQPRAGTGYASPDRTHVLAAGKAEETLEAWRPPPPCLTSLASCVPASSVLPTDRNLPTPTSAPTPGLAQGVHAPSTCSYMEATASSRARISRSISLGDSEGPIVATLAQPLRRPSSVGELASLGQELQAITTATTPSLDSEGQEPALRSWGNHEARANLRLTLSSACDGLLQPPVDTQPGVTVPAVSFPAPSPVEESALRLHGSAFRPSLPAPESPGLPAHPSNPQLPEARPGIPGGTASLLEPTSGALGLLQGSPARWSEPWVPVEALPPSPLELSRVGNILHRLQTTFQEALDLYRVLVSSGQVDTGQQQARTELVSTFLWIHSQLEAECLVGTSVAPAQALPSPGPPSPPTLYPLASPDLQALLEHYSELLVQAVRRKARGH"},{"id":"SEQ_04236","a":"Q9UPU3","g":"SORCS3","d":"VPS10 domain-containing receptor SorCS3","L":1222,"m":[{"c":"ψφxS[STF]DxGx[TS][YW]x[KQ]φ","u":14,"sp":"dispersed","x":"structured_like","cf":"high","why":"Four dispersed 14-residue repeats within the structured ectodomain-like region, anchored by invariant S4, D6, and G8 positions, a conserved [TS][YW] turn-aromatic pair, N-terminal hydrophobic residues (ψφ), and a C-terminal [KQ]φ dyad.","i":[[230,243,"LWRSTDYGTTYEKL"],[278,291,"ILISSDEGATYQKY"],[591,604,"VFISSDGGNTWRQI"],[633,646,"LWVSFDEGHSWDKY"]]}],"s":"MEAARTERPAGRPGAPLVRTGLLLLSTWVLAGAEITWDATGGPGRPAAPASRPPALSPLSPRAVASQWPEELASARRAAVLGRRAGPELLPQQGGGRGGEMQVEAGGTSPAGERRGRGIPAPAKLGGARRSRRAQPPITQERGDAWATAPADGSRGSRPLAKGSREEVKAPRAGGSAAEDLRLPSTSFALTGDSAHNQAMVHWSGHNSSVILILTKLYDFNLGSVTESSLWRSTDYGTTYEKLNDKVGLKTVLSYLYVNPTNKRKIMLLSDPEMESSILISSDEGATYQKYRLTFYIQSLLFHPKQEDWVLAYSLDQKLYSSMDFGRRWQLMHERITPNRFYWSVAGLDKEADLVHMEVRTTDGYAHYLTCRIQECAETTRSGPFARSIDISSLVVQDEYIFIQVTTSGRASYYVSYRREAFAQIKLPKYSLPKDMHIISTDENQVFAAVQEWNQNDTYNLYISDTRGIYFTLAMENIKSSRGLMGNIIIELYEVAGIKGIFLANKKVDDQVKTYITYNKGRDWRLLQAPDVDLRGSPVHCLLPFCSLHLHLQLSENPYSSGRISSKETAPGLVVATGNIGPELSYTDIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHTPLPVRHLWVSFDEGHSWDKYGFTSVPLFVDGALVEAGMETHIMTVFGHFSLRSEWQLVKVDYKSIFSRHCTKEDYQTWHLLNQGEPCVMGERKIFKKRKPGAQCALGRDHSGSVVSEPCVCANWDFECDYGYERHGESQCVPAFWYNPASPSKDCSLGQSYLNSTGYRRIVSNNCTDGLREKYTAKAQMCPGKAPRGLHVVTTDGRLVAEQGHNATFIILMEEGDLQRTNIQLDFGDGIAVSYANFSPIEDGIKHVYKSAGIFQVTAYAENNLGSDTAVLFLHVVCPVEHVHLRVPFVAIRNKEVNISAVVWPSQLGTLTYFWWFGNSTKPLITLDSSISFTFLAEGTDTITVQVAAGNALIQDTKEIAVHEYFQSQLLSFSPNLDYHNPDIPEWRKDIGNVIKRALVKVTSVPEDQILIAVFPGLPTSAELFILPPKNLTERRKGNEGDLEQIVETLFNALNQNLVQFELKPGVQVIVYVTQLTLAPLVDSSAGHSSSAMLMLLSVVFVGLAVFLIYKFKRKIPWINIYAQVQHDKEQEMIGSVSQSENAPKITLSDFTEPEELLDKELDTRVIGGIATIANSESTKEIPNCTSV"},{"id":"SEQ_04252","a":"P17096","g":"HMGA1","d":"High mobility group protein HMG-I/HMG-Y","L":107,"m":[{"c":"++[GP]RGRP+","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed copies of an 8-residue basic-proline-glycine motif anchored by an invariant RGRP core flanked by conserved N-terminal dibasic (++) and C-terminal basic (+) positions within a polar/charged disordered sequence.","i":[[23,30,"KRGRGRPR"],[55,62,"KRPRGRPK"],[81,88,"RKPRGRPK"]]}],"s":"MSESSSKSSQPLASKQEKDGTEKRGRGRPRKQPPVSPGTALVGSQKEPSEVPTPKRPRGRPKGSKNKGAAKTRKTTTTPGRKPRGRPKKLEKEEEEGISQESSEEEQ"},{"id":"SEQ_04253","a":"Q6RFH8","g":"DUX4L9","d":"Double homeobox protein 4C","L":374,"m":[{"c":"GRR+RxφφT[GP]SQ[ST]xφLxxxFE+[DN]xΩPGIAxRExLAxxxGψPExRψQIWFQNxRxR","u":55,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two ungapped 55-residue structured repeats separated by a 20-aa linker in the N-terminal half, sharing extensive fixed anchors including GRR+R, SQ, FE+[DN]xΩPGIA, RE, LA, GψPE, and RψQIWFQNxRxR.","i":[[19,73,"GRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSR"],[94,148,"GRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRAR"]]}],"s":"MALPTPSDSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQHRRESRPWPGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARHPGQGGRAPAQAGGLCSAAPGGGHPAPSWVAFAHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGISQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLPGPCAVAQPGPAQAGPQGQGVLAPPTSQGSPWWGWGRGPQVAGAAWEPQAGAAPPPQPAPPDASAASTDASHPGASQPLQEPGRSSTVTSSLLYELL"},{"id":"SEQ_04256","a":"Q76M96","g":"CCDC80","d":"Coiled-coil domain-containing protein 80","L":950,"m":[{"c":"[DN]φLx[RS]Fxx+xRψφψI[ST]APxx[ES][DEN]xφYx[LQ][MQ]x[DS]xφxxxφ[CY]xxxx[ER][KRH][HI][IST]xxxψφ(x){45,50}MψL(x){20,21}Ω-ψIDox[PQ]xR[IR]x-[KM]xxQ[KQ]xx[GV]xxC","u":"142-147","sp":"dispersed","x":"structured_like","cf":"high","why":"Three copies of a 142-147 residue structured domain (one N-terminal copy separated by a long disordered linker from two C-terminal copies) defined by conserved N-terminal ([DN]φLx[RS]F...RψφψI[ST]AP...Y), internal (MψL...Ω), and C-terminal (-ψID...R...Q...C) signature blocks.","i":[[140,281,"NILASFAGKNRVWVISAPHASEGYYRLMMSLLKDDVYCELAERHIQQIVLFHQAGEEGGKVRRITSEGQILEQPLDPSLIPKLMSFLKLEKGKFGMVLLKKTLQVEERYPYPVRLEAMYEVIDQGPIRRIEKIRQKGFVQKC"],[614,760,"DLLGSFEGKRRLLLITAPKAENNMYVQQRDEYLESFCKMATRKISVITIFGPVNNSTMKIDHFQLDNEKPMRVVDDEDLVDQRLISELRKEYGMTYNDFFMVLTDVDLRVKQYYEVPITMKSVFDLIDTFQSRIKDMEKQKKEGIVC"],[770,913,"NFLSRFRWRRRLLVISAPNDEDWAYSQQLSALSGQACNFGLRHITILKLLGVGEEVGGVLELFPINGSSVVEREDVPAHLVKDIRNYFQVSPEYFSMLLVGKDGNVKSWYPSPMWSMVIVYDLIDSMQLRRQEMAIQQSLGMRC"]]}],"s":"MTWRMGPRFTMLLAMWLVCGSEPHPHATIRGSHGGRKVPLVSPDSSRPARFLRHTGRSRGIERSTLEEPNLQPLQRRRSVPVLRLARPTEPPARSDINGAAVRPEQRPAARGSPREMIRDEGSSARSRMLRFPSGSSSPNILASFAGKNRVWVISAPHASEGYYRLMMSLLKDDVYCELAERHIQQIVLFHQAGEEGGKVRRITSEGQILEQPLDPSLIPKLMSFLKLEKGKFGMVLLKKTLQVEERYPYPVRLEAMYEVIDQGPIRRIEKIRQKGFVQKCKASGVEGQVVAEGNDGGGGAGRPSLGSEKKKEDPRRAQVPPTRESRVKVLRKLAATAPALPQPPSTPRATTLPPAPATTVTRSTSRAVTVAARPMTTTAFPTTQRPWTPSPSHRPPTTTEVITARRPSVSENLYPPSRKDQHRERPQTTRRPSKATSLESFTNAPPTTISEPSTRAAGPGRFRDNRMDRREHGHRDPNVVPGPPKPAKEKPPKKKAQDKILSNEYEEKYDLSRPTASQLEDELQVGNVPLKKAKESKKHEKLEKPEKEKKKKMKNENADKLLKSEKQMKKSEKKSKQEKEKSKKKKGGKTEQDGYQKPTNKHFTQSPKKSVADLLGSFEGKRRLLLITAPKAENNMYVQQRDEYLESFCKMATRKISVITIFGPVNNSTMKIDHFQLDNEKPMRVVDDEDLVDQRLISELRKEYGMTYNDFFMVLTDVDLRVKQYYEVPITMKSVFDLIDTFQSRIKDMEKQKKEGIVCKEDKKQSLENFLSRFRWRRRLLVISAPNDEDWAYSQQLSALSGQACNFGLRHITILKLLGVGEEVGGVLELFPINGSSVVEREDVPAHLVKDIRNYFQVSPEYFSMLLVGKDGNVKSWYPSPMWSMVIVYDLIDSMQLRRQEMAIQQSLGMRCPEDEYAGYGYHSYHQGYQDGYQDDYRHHESYHHGYPY"},{"id":"SEQ_04261","a":"Q9BYE0","g":"HES7","d":"Transcription factor HES-7","L":225,"m":[{"c":"P+P[PVS]x","u":5,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Four contiguous head-to-tail 5-aa repeats in the proline-rich C-terminal disordered region anchored by fixed P at positions 1 and 3 flanking a conserved basic residue (+ = K/R) at position 2, with a 10-aa super-period (PKPPRPKPVD / PRPPAPRPSL).","i":[[128,132,"PKPPR"],[133,137,"PKPVD"],[138,142,"PRPPA"],[143,147,"PRPSL"]]}],"s":"MVTRDRAENRDGPKMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNPKLEKAEILEFAVGYLRERSRVEPPGVPRSPVQDAEALASCYLSGFRECLLRLAAFAHDASPAARAQLFSALHGYLRPKPPRPKPVDPRPPAPRPSLDPAAPALGPALHQRPPVHQGHPSPRCAWSPSLCSPRAGDSGAPAPLTGLLPPPPPPHRQDGAPKAPLPPPPAFWRPWP"},{"id":"SEQ_04266","a":"Q6AI39","g":"BICRAL","d":"BRD4-interacting chromatin-remodeling complex-associated protein-like","L":1079,"m":[{"c":"H[VL]xxGx[ST]FA[SA]","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 10-aa motifs in the N-terminal disordered region sharing four invariant anchors (H1, G5, F8, A9) and three tightly constrained positions ([VL]2, [ST]7, [SA]10) with fixed internal spacing.","i":[[170,179,"HVPVGASFAS"],[337,346,"HVQQGISFAS"],[471,480,"HLVSGQTFAA"]]}],"s":"MDDDDDSCLLDLIGDPQALNYFLHGPSNKSSNDDLTNAGYSAANSNSIFANSSNADPKSSLKGVSNQLGEGPSDGLPLSSSLQFLEDELESSPLPDLTEDQPFDILQKSLQEANITEQTLAEEAYLDASIGSSQQFAQAQLHPSSSASFTQASNVSNYSGQTLQPIGVTHVPVGASFASNTVGVQHGFMQHVGISVPSQHLSNSSQISGSGQIQLIGSFGNHPSMMTINNLDGSQIILKGSGQQAPSNVSGGLLVHRQTPNGNSLFGNSSSSPVAQPVTVPFNSTNFQTSLPVHNIIIQRGLAPNSNKVPINIQPKPIQMGQQNTYNVNNLGIQQHHVQQGISFASASSPQGSVVGPHMSVNIVNQQNTRKPVTSQAVSSTGGSIVIHSPMGQPHAPQSQFLIPTSLSVSSNSVHHVQTINGQLLQTQPSQLISGQVASEHVMLNRNSSNMLRTNQPYTGPMLNNQNTAVHLVSGQTFAASGSPVIANHASPQLVGGQMPLQQASPTVLHLSPGQSSVSQGRPGFATMPSVTSMSGPSRFPAVSSASTAHPSLGSAVQSGSSGSNFTGDQLTQPNRTPVPVSVSHRLPVSSSKSTSTFSNTPGTGTQQQFFCQAQKKCLNQTSPISAPKTTDGLRQAQIPGLLSTTLPGQDSGSKVISASLGTAQPQQEKVVGSSPGHPAVQVESHSGGQKRPAAKQLTKGAFILQQLQRDQAHTVTPDKSHFRSLSDAVQRLLSYHVCQGSMPTEEDLRKVDNEFETVATQLLKRTQAMLNKYRCLLLEDAMRINPSAEMVMIDRMFNQEERASLSRDKRLALVDPEGFQADFCCSFKLDKAAHETQFGRSDQHGSKASSSLQPPAKAQGRDRAKTGVTEPMNHDQFHLVPNHIVVSAEGNISKKTECLGRALKFDKVGLVQYQSTSEEKASRREPLKASQCSPGPEGHRKTSSRSDHGTESKLSSILADSHLEMTCNNSFQDKSLRNSPKNEVLHTDIMKGSGEPQPDLQLTKSLETTFKNILELKKAGRQPQSDPTVSGSVELDFPNFSPMASQENCLEKFIPDHSEGVVETDSILEAAVNSILEC"},{"id":"SEQ_04279","a":"Q9BVN2","g":"RUSC1","d":"AP-4 complex accessory subunit RUSC1","L":902,"m":[{"c":"xxW+xx","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Seven clustered copies in an intrinsically disordered region (aa 227-302) anchored by an invariant W+ (WK/WR) dyad, preceded by small turn-favoring residues (P/A/T/S/G, with G/S at -1 in 5/7 copies) and ending with a conserved polar/acidic residue (N/D/E/T in 7/7 copies).","i":[[227,232,"PSWKIN"],[233,238,"PIWKID"],[244,249,"AEWKTT"],[254,259,"TGWKNN"],[264,269,"SSWKSE"],[275,280,"SGWKTN"],[297,302,"GGWRSD"]]},{"c":"[PA][PL]VPPR","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three closely spaced hexamer repeats in the central proline-rich disordered region (aa 384-410) anchored by an invariant VPPR core and constrained [PA][PL] N-terminal positions separated by 6- and 3-residue linkers.","i":[[383,388,"PPVPPR"],[395,400,"ALVPPR"],[404,409,"PPVPPR"]]}],"s":"MLSPQRALLCNLNHIHLQHVSLGLHLSRRPELQEGPLSTPPPPGDTGGKESRGPCSGTLVDANSNSPAVPCRCCQEHGPGLENRQDPSQEEEGAASPSDPGCSSSLSSCSDLSPDESPVSVYLRDLPGDEDAHPQPSIIPLEQGSPLASAGPGTCSPDSFCCSPDSCSGASSSPDPGLDSNCNALTTCQDVPSPGLEEEDERAEQDLPTSELLEADDGKIDAGKTEPSWKINPIWKIDTEKTKAEWKTTENNNTGWKNNGNVNSSWKSEPEKFDSGWKTNTRITDSGSKTDAGKIDGGWRSDVSEEPVPHRTITSFHELAQKRKRGPGLPLVPQAKKDRSDWLIVFSPDTELPPSGSPGGSSAPPREVTTFKELRSRSRAPAPPVPPRDPPVGWALVPPRPPPPPVPPRRKKNRPGLQPIAEGQSEEGRAVSPAAGEEAPAAKEPGAQAGLEVRSSWSFAGVPGAQRLWMAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNLVQKAQLGDSRLSPDVGHLVLTTLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSSTRSLGTLYSQVSRLAPLSSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLSLLYLPTGFFSLARGGCPSLSTELLLLLQPLSVLTFHLDLLFEHHHHLPLGPPQAPAPPGPPPALQQTMQAMLHFGGRLAQSLRGTSKEAASDPSDSPNLPTPGSWWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQERPLPTDEMAPGRGLWLGRLFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSPQELEASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEGLVPVGYTSLVL"},{"id":"SEQ_04298","a":"Q2TBE0","g":"CWF19L2","d":"Pre-mRNA splicing factor CWF19L2","L":894,"m":[{"c":"[ER]D[ET]W[MV]","u":5,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed copies of a 5-residue acidic-tryptophan motif clustered in the N-terminal disordered region (residues 55-155), anchored by invariant D2 and rare W4 followed by a large aliphatic [MV]5.","i":[[55,59,"EDTWM"],[116,120,"EDEWV"],[151,155,"RDEWM"]]}],"s":"MATSMAAASGRFESAKSIEERKEQTRNARAEVLRQAKANFEKEERRKELKRLRGEDTWMLPDVNERIEQFSQEHSVKKKKKKDKHSKKAKKEKKKKSKKQKYEKNNESSDSSSSSEDEWVEAVPSQTPDKEKAWKVKDEKSGKDDTQIIKRDEWMTVDFMSVKTVSSSSLKAEKETMRKIEQEKNQALEQSKLMERELNPYWKDGGTGLPPEDCSVSSITKVSVVEDGGLSWLRKSYLRMKEQAEKQSRNFEDIVAERYGSMEIFQSKLEDAEKAASTKEDYRRERWRKPTYSDKAQNCQESRESDLVKYGNSSRDRYATTDTAKNSNNEKFIGDEKDKRPGSLETCRRESNPRQNQEFSFGNLRAKFLRPSDDEELSFHSKGRKFEPLSSSSALVAQGSLCSGFRKPTKNSEERLTSWSRSDGRGDKKHSNQKPSETSTDEHQHVPEDPREKSQDEVLRDDPPKKEHLRDTKSTFAGSPERESIHILSVDEKNKLGAKIIKAEMMGNMELAEQLKVQLEKANKFKETITQIPKKSGVENEDQQEVILVRTDQSGRVWPVNTPGKSLESQGGRRKRQMVSTHEERERVRYFHDDDNLSLNDLVKNEKMGTAENQNKLFMRMASKFMGKTDGDYYTLDDMFVSKAAERERLGEEEENQRKKAIAEHRSLAAQMEKCLYCFDSSQFPKHLIVAIGVKVYLCLPNVRSLTEGHCLIVPLQHHRAATLLDEDIWEEIQMFRKSLVKMFEDKGLDCIFLETNMSMKKQYHMVYECIPLPKEVGDMAPIYFKKAIMESDEEWSMNKKLIDLSSKDIRKSVPRGLPYFSVDFGLHGGFAHVIEDQHKFPHYFGKEIIGGMLDIEPRLWRKGIRESFEDQRKKALQFAQWWKPYDFTKSKNY"},{"id":"SEQ_04300","a":"Q6E0U4","g":"DMKN","d":"Dermokine","L":476,"m":[{"c":"ψφxFxxφWx[DN]FKoxx[GP]FψNWxAI","u":23,"sp":"dispersed","x":"structured_like","cf":"high","why":"Strongly conserved 23-residue duplicated motif in the C-terminal region separated by a 12-aa proline-containing linker, anchored by nine identical positions (three Fs, two Ws, K, N, A, I) and five conserved hydrophobic/aliphatic positions.","i":[[354,376,"MFNFDTFWKNFKSKLGFINWDAI"],[389,411,"LLYFSRLWEDFKQNTPFLNWKAI"]]},{"c":"[GS]xxxxx[AV]x","u":8,"sp":"tandem","x":"mixed","cf":"high","why":"Contiguous head-to-tail array of nine 8-residue repeats in the N-terminal region featuring near-invariant G at position 1 (8/9), A at position 7 (8/9), and strong enrichment of G at positions 3/5, aliphatic residues at positions 4/8, and acidic residues at position 6.","i":[[32,39,"GTNIGEAL"],[40,47,"GHGLGDAL"],[48,55,"SEGVGKAI"],[56,63,"GKEAGGAA"],[64,71,"GSKVSEAL"],[72,79,"GQGTREAV"],[80,87,"GTGVRQVP"],[88,95,"GFGVADAL"],[96,103,"GNRVGEAA"]]}],"s":"MKFQGPLACLLLALCLGSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVGTGVRQVPGFGVADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPGMFNFDTFWKNFKSKLGFINWDAINKNQVPPPSTRALLYFSRLWEDFKQNTPFLNWKAIIEGADASSLQKRAGRDDQNYNYNQHAYPTAYGGKYSVKTPAKGGVSPSSSASRVQPGLLQWVKFW"},{"id":"SEQ_04309","a":"Q6ZN17","g":"LIN28B","d":"Protein lin-28 homolog B","L":250,"m":[{"c":"+C[HY]xCx[GS]ψxHx[AV]xxC","u":15,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two 15-residue CCHC zinc-knuckle repeats separated by a 7-residue proline-rich linker (SLPPQPK), sharing four invariant C/H coordinating anchors alongside conserved N-terminal basic (+), aromatic/his ([HY]), aliphatic (ψ), and small aliphatic ([AV]) positions.","i":[[128,142,"RCYNCGGLDHHAKEC"],[150,164,"KCHYCQSIMHMVANC"]]}],"s":"MAEGGASKGGGEEPGKLPEPAEEESQVLRGTGHCKWFNVRMGFGFISMINREGSPLDIPVDVFVHQSKLFMEGFRSLKEGEPVEFTFKKSSKGLESIRVTGPGGSPCLGSERRPKGKTLQKRKPKGDRCYNCGGLDHHAKECSLPPQPKKCHYCQSIMHMVANCPHKNVAQPPASSQGRQEAESQPCTSTLPREVGGGHGCTSPPFPQEARAEISERSGRSPQEASSTKSSIAPEEQSKKGPSVQKRKKT"},{"id":"SEQ_04313","a":"Q8WY21","g":"SORCS1","d":"VPS10 domain-containing receptor SorCS1","L":1168,"m":[{"c":"[SH][LM]φxSxDxGx[TS][YW]x[KQ]φ","u":15,"sp":"dispersed","x":"structured_like","cf":"high","why":"Four 15-residue repeats distributed across residues 206-624 in a structured region, anchored by an invariant SxDxG core alongside conserved N-terminal [SH][LM]φ and C-terminal [TS][YW]x[KQ]φ positions.","i":[[206,220,"SLWRSTDYGTTYEKL"],[254,268,"SLLISSDEGATYQKY"],[567,581,"SMFVSSDAGNTWRQI"],[609,623,"HLWLSFDEGRSWSKY"]]}],"s":"MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQGRPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAERGEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNKRKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQPFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFLANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQLVKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEPCVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDGVREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDGIAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFVTTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAGNAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHILVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVLVHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGDSSLRLQRARHATPPSTPKRGSAGAQYAI"},{"id":"SEQ_04323","a":"Q9NZ71","g":"RTEL1","d":"Regulator of telomere elongation helicase 1","L":1219,"m":[{"c":"φΩψφxφ+xxLxoAxxxoφxxALoxYKxxDDφxxψφAxLxxLxxxxPxxxxLLxxFxxFVRPHHKQxFxxxCxxLTGR","u":77,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two ungapped 77-residue structured domain duplications in the C-terminal region separated by an 87-residue proline/polar-rich linker, sharing 29 identical anchors (including ALxxYKxxDD, LLxxFxxFVRPHHKQxF, and CxxLTGR) plus conserved hydrophobic cores.","i":[[898,974,"LFMVAVKQELSQANFATFTQALQDYKGSDDFAALAACLGPLFAEDPKKHNLLQGFYQFVRPHHKQQFEEVCIQLTGR"],[1062,1138,"AYLADARRALGSAGCSQLLAALTAYKQDDDLDKVLAVLAALTTAKPEDFPLLHRFSMFVRPHHKQRFSQTCTDLTGR"]]}],"s":"MPKIVLNGVTVDFPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAWREHLRDGISARKIAERAQGELFPDRALSSWGNAAAAAGDPIACYTDIPKIIYASRTHSQLTQVINELRNTSYRPKVCVLGSREQLCIHPEVKKQESNHLQIHLCRKKVASRSCHFYNNVEEKSLEQELASPILDIEDLVKSGSKHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNIDLKGTVVIFDEAHNVEKMCEESASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFSADSPSPGLNMELEDIAKLKMILLRLEGAIDAVELPGDDSGVTKPGSYIFELFAEAQITFQTKGCILDSLDQIIQHLAGRAGVFTNTAGLQKLADIIQIVFSVDPSEGSPGSPAGLGALQSYKVHIHPDAGHRRTAQRSDAWSTTAARKRGKVLSYWCFSPGHSMHELVRQGVRSLILTSGTLAPVSSFALEMQIPFPVCLENPHIIDKHQIWVGVVPRGPDGAQLSSAFDRRFSEECLSSLGKALGNIARVVPYGLLIFFPSYPVMEKSLEFWRARDLARKMEALKPLFVEPRSKGSFSETISAYYARVAAPGSTGATFLAVCRGKASEGLDFSDTNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMKGQGGAGGQFLSGQEWYRQQASRAVNQAIGRVIRHRQDYGAVFLCDHRFAFADARAQLPSWVRPHVRVYDNFGHVIRDVAQFFRVAERTMPAPAPRATAPSVRGEDAVSEAKSPGPFFSTRKAKSLDLHVPSLKQRSSGSPAAGDPESSLCVEYEQEPVPARQRPRGLLAALEHSEQRAGSPGEEQAHSCSTLSLLSEKRPAEEPRGGRKKIRLVSHPEEPVAGAQTDRAKLFMVAVKQELSQANFATFTQALQDYKGSDDFAALAACLGPLFAEDPKKHNLLQGFYQFVRPHHKQQFEEVCIQLTGRGCGYRPEHSIPRRQRAQPVLDPTGRTAPDPKLTVSTAAAQQLDPQEHLNQGRPHLSPRPPPTGDPGSQPQWGSGVPRAGKQGQHAVSAYLADARRALGSAGCSQLLAALTAYKQDDDLDKVLAVLAALTTAKPEDFPLLHRFSMFVRPHHKQRFSQTCTDLTGRPYPGMEPPGPQEERLAVPPVLTHRAPQPGPSRSEKTGKTQSKISSFLRQRPAGTVGAGGEDAGPSQSSGPPHGPAASEWGL"},{"id":"SEQ_04332","a":"Q8N1G0","g":"ZNF687","d":"Zinc finger protein 687","L":1237,"m":[{"c":"xxCxxC(x){11,15}H(x){3,4}[HC]","u":"23-27","sp":"dispersed","x":"structured_like","cf":"high","why":"Twelve C2H2/C2HC zinc-finger repeats across the C-terminal half, anchored by invariant CxxC and H(x){3,4}[HC] metal-coordinating motifs with conserved central hydrophobic core residues (frequently F/L), arranged in multi-finger clusters separated by variable disordered linkers.","i":[[561,585,"VTCNHCARRLVFFNKCSLLLHAREH"],[705,727,"NVCPTCPMMLPNRCSFSAHQRMH"],[733,755,"HVCPECGGNFLQANFQTHLREAC"],[764,787,"YRCPSCSVVFGGVNSIKSHIQTSH"],[792,815,"HKCPICPMAFKSGPSAHAHLYSQH"],[827,849,"YKCAMCDTVFTHKPLLSSHFDQH"],[858,881,"FKCPSCPLLFAQKRTMLEHLKNTH"],[963,986,"WTCGLCHSWFPERDEYVAHMKKEH"],[993,1016,"FPCRLCERSFCSAPSLRRHVRVNH"],[1023,1049,"YPCRYCTEGKRTFSSRLILEKHVQVRH"],[1135,1158,"QQCLDCGLCFASPGSLSRHRFISH"],[1200,1222,"LTCKVCGKSCDSPLNLKTHFRTH"]]}],"s":"MGDMKTPDFDDLLAAFDIPDIDANEAIHSGPEENEGPGGPGKPEPGVGSESEDTAAASAGDGPGVPAQASDHGLPPPDISVVSVIVKNTVCPEQSEALAGGSAGDGAQAAGVTKEGPVGPHRMQNGFGSPEPSLPGTPHSPAPPSGGTWKEKGMEGKTPLDLFAHFGPEPGDHSDPLPPSAPSPTREGALTPPPFPSSFELAQENGPGMQPPVSSPPLGALKQESCSPHHPQVLAQQGSGSSPKATDIPASASPPPVAGVPFFKQSPGHQSPLASPKVPVCQPLKEEDDDEGPVDKSSPGSPQSPSSGAEAADEDSNDSPASSSSRPLKVRIKTIKTSCGNITRTVTQVPSDPDPPAPLAEGAFLAEASLLKLSPATPTSEGPKVVSVQLGDGTRLKGTVLPVATIQNASTAMLMAASVARKAVVLPGGTATSPKMIAKNVLGLVPQALPKADGRAGLGTGGQKVNGASVVMVQPSKTATGPSTGGGTVISRTQSSLVEAFNKILNSKNLLPAYRPNLSPPAEAGLALPPTGYRCLECGDAFSLEKSLARHYDRRSMRIEVTCNHCARRLVFFNKCSLLLHAREHKDKGLVMQCSHLVMRPVALDQMVGQPDITPLLPVAVPPVSGPLALPALGKGEGAITSSAITTVAAEAPVLPLSTEPPAAPATSAYTCFRCLECKEQCRDKAGMAAHFQQLGPPAPGATSNVCPTCPMMLPNRCSFSAHQRMHKNRPPHVCPECGGNFLQANFQTHLREACLHVSRRVGYRCPSCSVVFGGVNSIKSHIQTSHCEVFHKCPICPMAFKSGPSAHAHLYSQHPSFQTQQAKLIYKCAMCDTVFTHKPLLSSHFDQHLLPQRVSVFKCPSCPLLFAQKRTMLEHLKNTHQSGRLEETAGKGAGGALLTPKTEPEELAVSQGGAAPATEESSSSSEEEEVPSSPEPPRPAKRPRRELGSKGLKGGGGGPGGWTCGLCHSWFPERDEYVAHMKKEHGKSVKKFPCRLCERSFCSAPSLRRHVRVNHEGIKRVYPCRYCTEGKRTFSSRLILEKHVQVRHGLQLGAQSPGRGTTLARGSSARAQGPGRKRRQSSDSCSEEPDSTTPPAKSPRGGPGSGGHGPLRYRSSSSTEQSLMMGLRVEDGAQQCLDCGLCFASPGSLSRHRFISHKKRRGVGKASALGLGDGEEEAPPSRSDPDGGDSPLPASGGPLTCKVCGKSCDSPLNLKTHFRTHGMAFIRARQGAVGDN"},{"id":"SEQ_04358","a":"Q5T2S8","g":"ODAD2","d":"Outer dynein arm-docking complex subunit 2","L":1044,"m":[{"c":"xφφxxx[GKD][GA]φxxψφxφφ(x){6,22}xxxφφx[AT]ψxx[CIL][ASC](x){5,8}","u":"40-56","sp":"tandem","x":"structured_like","cf":"high","why":"Contiguous C-terminal tandem array of 13 structured ~41-42 aa alpha-solenoid repeats (residues 488-1038; copy 3 carries a 15-aa internal loop insertion) anchored by a conserved G[GA]φxxψφxLL helix-2 core and a hydrophobic/Cys-rich [AT]ψxx[CIL][ASC] helix-3 core.","i":[[488,528,"LAIRDVGGLEVLINLLETDEVKCKIGSLKILKEISHNPQIR"],[529,569,"QNIVDLGGLPIMVNILDSPHKSLKCLAAETIANVAKFKRAR"],[570,625,"RVVRQHGGITKLVALLDCAHDSTKPAQSSLYEARDVEVARCGALALWSCSKSHTNK"],[626,667,"EAIRKAGGIPLLARLLKTSHENMLIPVVGTLQECASEENYRA"],[668,707,"AIKAERIIENLVKNLNSENEQLQEHCAMAIYQCAEDKETR"],[708,749,"DLVRLHGGLKPLASLLNNTDNKERLAAVTGAIWKCSISKENV"],[750,790,"TKFREYKAIETLVGLLTDQPEEVLVNVVGALGECCQERENR"],[791,831,"VIVRKCGGIQPLVNLLVGINQALLVNVTKAVGACAVEPESM"],[832,874,"MIIDRLDGVRLLWSLLKNPHPDVKASAAWALCPCIKNAKDAGE"],[875,915,"MVRSFVGGLELIVNLLKSDNKEVLASVCAAITNIAKDQENL"],[916,956,"AVITDHGVVPLLSKLANTNNNKLRHHLAEAISRCCMWGRNR"],[957,996,"VAFGEHKAVAPLVRYLKSNDTNVHRATAQALYQLSEDADN"],[997,1038,"CITMHENGAVKLLLDMVGSPDQDLQEAAAGCISNIRRLALAT"]]}],"s":"MGVALRKLTQWTAAGHGTGILEITPLNEAILKEIIVFVESFIYKHPQEAKFVFVEPLEWNTSLAPSAFESGYVVSETTVKSEEVDKNGQPLLFLSVPQIKIRSFGQLSRLLLIAKTGKLKEAQACVEANRDPIVKILGSDYNTMKENSIALNILGKITRDDDPESEIKMKIAMLLKQLDLHLLNHSLKHISLEISLSPMTVKKDIELLKRFSGKGNQTVLESIEYTSDYEFSNGCRAPPWRQIRGEICYVLVKPHDGETLCITCSAGGVFLNGGKTDDEGDVNYERKGSIYKNLVTFLREKSPKFSENMSKLGISFSEDQQKEKDQLGKAPKKEEAAALRKDISGSDKRSLEKNQINFWRNQMTKRWEPSLNWKTTVNYKGKGSAKEIQEDKHTGKLEKPRPSVSHGRAQLLRKSAEKIEETVSDSSSESEEDEEPPDHRQEASADLPSEYWQIQKLVKYLKGGNQTATVIALCSMRDFSLAQETCQLAIRDVGGLEVLINLLETDEVKCKIGSLKILKEISHNPQIRQNIVDLGGLPIMVNILDSPHKSLKCLAAETIANVAKFKRARRVVRQHGGITKLVALLDCAHDSTKPAQSSLYEARDVEVARCGALALWSCSKSHTNKEAIRKAGGIPLLARLLKTSHENMLIPVVGTLQECASEENYRAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQCAEDKETRDLVRLHGGLKPLASLLNNTDNKERLAAVTGAIWKCSISKENVTKFREYKAIETLVGLLTDQPEEVLVNVVGALGECCQERENRVIVRKCGGIQPLVNLLVGINQALLVNVTKAVGACAVEPESMMIIDRLDGVRLLWSLLKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFVGGLELIVNLLKSDNKEVLASVCAAITNIAKDQENLAVITDHGVVPLLSKLANTNNNKLRHHLAEAISRCCMWGRNRVAFGEHKAVAPLVRYLKSNDTNVHRATAQALYQLSEDADNCITMHENGAVKLLLDMVGSPDQDLQEAAAGCISNIRRLALATEKARYT"},{"id":"SEQ_04367","a":"P10163","g":"PRB4","d":"Basic salivary proline-rich protein 4","L":310,"m":[{"c":"GKP[EQ][GRS][PR][PR][PQ](x){0,2}[QA][GE]G[NHR][QKP][SPQ][QHR](x){0,3}xxx[PS][PHT](x){0,1}","u":"20-26","sp":"tandem","x":"disordered_like","cf":"high","why":"Contiguous head-to-tail array of 13 tandem repeats spanning residues 34-310 (predominantly 21 aa, range 20-26 aa with minor C-terminal length variation), strongly anchored by invariant N-terminal GKP and central [QA][GE]G[NHR] motifs flanked by proline/polar-rich segments.","i":[[34,54,"GKPEGRRPQGGNQPQRPPPPP"],[55,75,"GKPQGPPPQGGNQSQGPPPPP"],[76,96,"GKPEGRPPQGGNQSQGPPPHP"],[97,117,"GKPERPPPQGGNQSQGPPPHP"],[118,138,"GKPESRPPQGGHQSQGPPPTP"],[139,159,"GKPEGPPPQGGNQSQGTPPPP"],[160,180,"GKPEGRPPQGGNQSQGPPPHP"],[181,201,"GKPERPPPQGGNQSHRPPPPP"],[202,222,"GKPERPPPQGGNQSQGPPPHP"],[223,243,"GKPEGPPPQEGNKSRSARSPP"],[244,263,"GKPQGPPQQEGNKPQGPPPP"],[264,284,"GKPQGPPPAGGNPQQPQAPPA"],[285,310,"GKPQGPPPPPQGGRPPRPAQGQQPPQ"]]}],"s":"MLLILLSVALLALSSAESSSEDVSQEESLFLISGKPEGRRPQGGNQPQRPPPPPGKPQGPPPQGGNQSQGPPPPPGKPEGRPPQGGNQSQGPPPHPGKPERPPPQGGNQSQGPPPHPGKPESRPPQGGHQSQGPPPTPGKPEGPPPQGGNQSQGTPPPPGKPEGRPPQGGNQSQGPPPHPGKPERPPPQGGNQSHRPPPPPGKPERPPPQGGNQSQGPPPHPGKPEGPPPQEGNKSRSARSPPGKPQGPPQQEGNKPQGPPPPGKPQGPPPAGGNPQQPQAPPAGKPQGPPPPPQGGRPPRPAQGQQPPQ"},{"id":"SEQ_04404","a":"Q96LK8","g":"SPATA32","d":"Spermatogenesis-associated protein 32","L":384,"m":[{"c":"[PQ][AS][PT][SE]PLLo","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed copies of an 8-residue linear motif in the P/S/T/E-rich C-terminal disordered region share an invariant PLL core flanked by tightly constrained N-terminal [PQ][AS][PT][SE] positions and a C-terminal polar residue (S/T/Q), with an additional divergent PLL site (EKENPLLV) nearby.","i":[[222,229,"QAPSPLLS"],[275,282,"PSTEPLLT"],[344,351,"PATSPLLQ"]]}],"s":"MGVTGAHGFPCCGKGSVEVAEMRDDLSQHQIQEEQELEADMLEQKPQLQVDLDLDPDPDPDPELEIGQVPALLESELYPALKLEAELDTEANSNEESDFEEPMQLVCKIESVHSNMGLPTPQTFRPWSLNSNCRSFTEENHVSACHHSISAQTSKHLFWANKLIQASEHSLQRAINMQLNNGSAGQPIRSPLREAIPTNALCSEEQLQIPDAHSAPPTTSSQAPSPLLSSDLPPPIDLTELITFASSLAMASSSRMDLPSLEHMMKAPPQEALEPSTEPLLTTVEEREPENHAETLPEKPREARAPLKSWSQEDKNFAQSYFDFSKPGIKRATIKGQIQLLQPPATSPLLQGSKEDSVPPGKEKENPLLVKIHFKLSAPTIPEK"},{"id":"SEQ_04405","a":"Q8N3Z6","g":"ZCCHC7","d":"Zinc finger CCHC domain-containing protein 7","L":543,"m":[{"c":"CxxCxxxGH[LY]xxxC","u":14,"sp":"dispersed","x":"structured_like","cf":"high","why":"Four 14-residue repeats in the central region share invariant C at positions 1, 4, and 14, an invariant GH dipeptide at positions 8-9, and a conserved hydrophobic [LY] residue at position 10, separated by variable linkers of 8 to 30 residues.","i":[[243,256,"CRNCDKRGHLSKNC"],[265,278,"CFLCSRRGHLLYSC"],[306,319,"CDRCHMLGHYTDAC"],[350,363,"CYHCAQKGHYGHEC"]]}],"s":"MMFGGYETIEAYEDDLYRDESSSELSVDSEVEFQLYSQIHYAQDLDDVIREEEHEEKNSGNSESSSSKPNQKKLIVLSDSEVIQLSDGSEVITLSDEDSIYRCKGKNVRVQAQENAHGLSSSLQSNELVDKKCKSDIEKPKSEERSGVIREVMIIEVSSSEEEESTISEGDNVESWMLLGCEVDDKDDDILLNLVGCENSVTEGEDGINWSISDKDIEAQIANNRTPGRWTQRYYSANKNIICRNCDKRGHLSKNCPLPRKVRRCFLCSRRGHLLYSCPAPLCEYCPVPKMLDHSCLFRHSWDKQCDRCHMLGHYTDACTEIWRQYHLTTKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHECPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPSKLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKNKNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHYHTSREDKSPKEGKRGKQKKKERCWEDDDNDNLFLIKQRKKKS"},{"id":"SEQ_04407","a":"Q9P266","g":"JCAD","d":"Junctional cadherin 5-associated protein","L":1359,"m":[{"c":"[LV]xPP[SV]Y","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three 6-residue copies clustered within a P/S/Q-rich disordered segment share fixed PP and C-terminal Y anchors, an N-terminal aliphatic [LV] residue, and a constrained [SV] choice at position 5, arranged as one copy separated by 36 residues from a head-to-tail pair.","i":[[293,298,"LKPPSY"],[335,340,"LEPPVY"],[341,346,"VPPPSY"]]}],"s":"MYSVEDLLISHGYKLSRDPPASREDNPKGRQAARTGTRAGQGLQNGHEDGPAALAHRKTSAGKGHVSDSESRRSTPRGHGEPQSTSASRTSEAGFCNQPPSAWSSHPPTGNDQAYRRRGRQEARSQKPREHENLEARGMAQAHSLPVHVREGPWEVGGRSEHVMKKPVWEEELRMSGPAKWQNVSLESWNQPRKLGRQMSDGDGERLFQDLYPFIQGEHVLNSQNKGKSRSLPRVLSPESLSCTEIPIPLNERHSPKMPPYPPTCAPNLDSTRNSEKSGCSAPFPRPKFGRPLKPPSYSSHQQSRGGADSSDSQDSQQMDAYVPRHELCLSDPGLEPPVYVPPPSYRSPPQNIPNPYLEDTVPINVCGGHSQQQSPTEKAGASGQPPSGPPGTGNEYGVSPRLPQGLPAHPRPVTAYDGFVQYIPFDDPRLRHFKLAQPQGFCEDIKLDDKSYNSSPVTAQEPAHGGMQPDGAIWNPQSLIPPSGDERGLVLADSSPRWLWGQPPGDGENSGLPNQRDRCVARGQWPDVRGSQHGHTGRQVSSPYSQGESTCETQTKLKKFQTGTRTKKSSKKKMNETIFCLVSIPVKSESHLPDRDMDNNDLKPSADQKNGSDKSPALQEQSLLSMSSTDLELQALTGSMGGRTEFQKQDLGEPEEDRQTNDLSFIHLTKHRELKHSGSWPGHRYRDQQTQTSFSEEPQSSQLLPGAKLGGPSRAALSPKCSDPAASEAQTHTAFPTGDHKQRPSARNLKGHRSLSPSSNSAFSRTSLSVDQAPTPKAGRSQPCVDVHGLGAHPGPKREVVKGEPTGPCNSKQLFGQFLLKPVSRRPWDLISQLESFNKELQEEEESSSSSSSSSSSSEESEAEPQQENRAHCRQEDVGFRGNSPEMRVEPQPRMWVPESPVCRSGRGESKSESWSEELQPGHPRAWPPSPGRFRVEEGGGAPFCSADGSTSAEKRHLEVSNGMDELAGSPFPVTRMSSRSSDAKPLPASYPAEPREPQESPKITSAFSSVKPSEAVPRKFDSGGERGAGLPLSLSNKNRGLSAPDLRSVGLTPGQEQGASELEGSLGEASTIEIPPGESLQARAARILGIEVAVESLLPGIRRAGQNQPAEPDASACTPESPQEELLSRPAPADVPRVSTDAFYGRRKCGWTKSPLFVGDRDSARRAPQAFEHSDVDGVVTSTDPVPEPEPSPLESKFFEQKDVETKPPFRSTLFHFVERTPSVAGSEKRLRSPSKVIESLQEKLASPPRRADPDRLMRMKEVSSVSRMRVLSFRNADSQEDAEELKATTRGQAGLPGGLVSPGSGDRAQRLGHSLSVSKDSISREEKEHPAAQKEKSMDQDFWCPDSYDPSRVERV"},{"id":"SEQ_04409","a":"Q9H2P0","g":"ADNP","d":"Activity-dependent neuroprotector homeobox protein","L":1102,"m":[{"c":"CxxC(x){8,12}φxxH(x){3,4}[HC]","u":"20-24","sp":"dispersed","x":"structured_like","cf":"high","why":"Nine dispersed 20-24 aa structured repeats anchored by an invariant N-terminal CxxC pair, a conserved hydrophobic residue three positions before the first H, and a C-terminal H(x){3,4}[HC] motif.","i":[[76,97,"CSACPFSSKFFSAYKSHFRNVH"],[109,129,"CPYCTFNADKKTLETHIKIFH"],[167,188,"CKKCTYRDPLYEIVRKHIYREH"],[223,244,"CKRCLFMPKSYEALVQHVIEDH"],[449,469,"CTICNELFPENVYSVHFEKEH"],[491,510,"CLYCNRYLPTDTLLNHMLIH"],[514,535,"CPYCRSTFNDVEKMAAHMRMVH"],[624,647,"CPLCFSILKGPISDALAHHLRERH"],[664,687,"CIHCLGVYTSNMTASTITLHLVHC"]]},{"c":"QxxW[KQ]N[SA][ST]","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three closely spaced (9-11 aa linkers) 8-aa motifs in the C-terminal polar/acidic disordered region anchored by invariant Q, W, and N positions and tightly constrained [KQ]N[SA][ST] C-terminal residues.","i":[[1025,1032,"QLKWKNSS"],[1044,1051,"QSQWKNAS"],[1061,1068,"QIEWQNST"]]}],"s":"MFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQDYRTKPFCCSACPFSSKFFSAYKSHFRNVHSEDFENRILLNCPYCTFNADKKTLETHIKIFHAPNASAPSSSLSTFKDKNKNDGLKPKQADSVEQAVYYCKKCTYRDPLYEIVRKHIYREHFQHVAAPYIAKAGEKSLNGAVPLGSNAREESSIHCKRCLFMPKSYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRSKPLMLIAPKPQDKKSMGLPPRIGSLASGNVRSLPSQQMVNRLSIPKPNLNSTGVNMMSSVHLQQNNYGVKSVGQGYSVGQSMRLGLGGNAPVSIPQQSQSVKQLLPSGNGRSYGLGSEQRSQAPARYSLQSANASSLSSGQLKSPSLSQSQASRVLGQSSSKPAAAATGPPPGNTSSTQKWKICTICNELFPENVYSVHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPTDTLLNHMLIHGLSCPYCRSTFNDVEKMAAHMRMVHIDEEMGPKTDSTLSFDLTLQQGSHTNIHLLVTTYNLRDAPAESVAYHAQNNPPVPPKPQPKVQEKADIPVKSSPQAAVPYKKDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQDKTNAPSRLNQSPSLAPVKRTYEQMEFPLLKKRKLDDDSDSPSFFEEKPEEPVVLALDPKGHEDDSYEARKSFLTKYFNKQPYPTRREIEKLAASLWLWKSDIASHFSNKRKKCVRDCEKYKPGVLLGFNMKELNKVKHEMDFDAEWLFENHDEKDSRVNASKTADKKLNLGKEDDSSSDSFENLEEESNESGSPFDPVFEVEPKISNDNPEEHVLKVIPEDASESEEKLDQKEDGSKYETIHLTEEPTKLMHNASDSEVDQDDVVEWKDGASPSESGPGSQQVSDFEDNTCEMKPGTWSDESSQSEDARSSKPAAKKKATMQGDREQLKWKNSSYGKVEGFWSKDQSQWKNASENDERLSNPQIEWQNSTIDSEDGEQFDNMTDGVAEPMHGSLAGVKLSSQQA"},{"id":"SEQ_04418","a":"Q99666","g":"RGPD5","d":"RANBP2-like and GRIP domain-containing protein 5/6","L":1765,"m":[{"c":"FEPVVxψP-xVEψx[ST]GEExExVψΩSxxφxψΩRΩDx-VxQWKERGψG[ND]ψKILxNxxNxxψRψψMRR-QVLKψCANHxITxxMoLxxψxG[ST]-RφWψW[ST]A[SC]DF[SA]DG-xKψE[RH]LAφ+FKxx-ψA-xFKxxF-ExxxφxxxxxLxTPH","u":143,"sp":"dispersed","x":"structured_like","cf":"high","why":"Gapless 143-residue internal duplication separated by a 153-residue disordered linker, sharing ~52% identity across multiple invariant motifs (FEPVV, QWKERG, MRR-QVLK, CANH, RφWψW, LxTPH) and conserved hydrophobic cores.","i":[[1037,1179,"FEPVVQMPEKVELVTGEEGEKVLYSQGVKLFRFDAEVRQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSGSDRAWMWSASDFSDGDAKLERLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPH"],[1334,1476,"FEPVVPLPDLVEVSSGEENEQVVFSHRAEIYRYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMSLQNMKGTERVWVWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPH"]]},{"c":"[GP]FxFG","u":5,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 5-residue copies in the flanking polar/proline/serine-enriched disordered regions anchored by fixed aromatic F at positions 2 and 4, C-terminal G, and N-terminal G/P.","i":[[921,925,"GFKFG"],[982,986,"GFQFG"],[1556,1560,"PFVFG"]]}],"s":"MRRSKADVERYVASVLGLTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDPKAHRFLGLLYELEENTEKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWVERAAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVELYRSTKRLKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWQATNTDLLLAYANLMLLTLSTRDVQENRELLESFDSALQSAKSSLGGNDELSATFLEMKGHFYMYAGSLLLKMGQHGNNVQWRALSELAALCYLIAFQVPRPKIKLREGKAGQNLLEMMACDRLSQSGHMLLSLSRGKQDFLKEVVETFANKIGQSALYDALFSSQSPKDTSFLGSDDIGKIDVQEPELEDLARYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHRLPHETSRLETNAPESICILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPFPVCKQLCTERQKSWWDAVCTLIHRKAVPGNLAKLRLLVQHEINTLRAQEKHGLQPALLVHWAKYLQKTGSGLNSFYGQLEYIGRSVHYWKKVLPLLKIIKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAMLDAVNGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECRNYLTKTRDYLIKIIDDGDSNLSVVKKLPVPLESVKQMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTPSPTKYSLSPSKSYKYSPETPPRWTEDRNSLLNMICQQVEAIKKEMQELKLNSSKSASRHRWPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKREKPLENDTGFQAQDISGRKKGRGVIFGQTSSTFTFADVAKSTSGEGFQFGKKDLNFKGFSGAGEKLFSSRYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEGEKVLYSQGVKLFRFDAEVRQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSGSDRAWMWSASDFSDGDAKLERLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNAENTGPTLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFDESTTGSNFSFKSALSLSKSPAKLNQSGTSVGTDEESVVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAEIYRYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMSLQNMKGTERVWVWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPRESPCGKIAVAILEETTRERTDVIQGDDVADAASEVEVSSTSETTTKAVVSPPKFVFVSESVKRIFSSEKSKPFVFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELSKNSDIEQSSDSKVKNLSASFPTEESSINYTFKTPEKEPPLWHAEFTKEELVQKLRSTTKSADHLNGLLREIEATNAVLMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQDEEENASRSSG"},{"id":"SEQ_04429","a":"Q9UM47","g":"NOTCH3","d":"Neurogenic locus notch homolog protein 3","L":2321,"m":[{"c":"[DN]ψ[DN][EDP]C(x){3,13}PC(x){1,4}GGxC(x){4,11}ΩxCxCPxGΩxGxxCx","u":"35-47","sp":"tandem","x":"structured_like","cf":"high","why":"34-copy tandem array of 6-cysteine structured repeats spanning residues 39-1373, anchored by a conserved N-terminal [DN]ψ[DN][EDP]C motif, PC and GGxC sub-motifs, an invariant CxC pair, and an 8-residue C-terminal PxGΩxGxxC loop.","i":[[39,77,"AAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQ"],[78,118,"LEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCS"],[119,156,"LPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCR"],[158,195,"DVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCE"],[197,234,"PAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCE"],[236,272,"NVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCT"],[274,312,"DVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCS"],[314,350,"NIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCH"],[351,389,"LDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACD"],[391,429,"DVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCE"],[431,467,"DVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCE"],[469,505,"DIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQ"],[507,543,"DVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCD"],[545,580,"NVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCE"],[582,618,"QVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCE"],[620,655,"NIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCN"],[657,693,"EINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCL"],[695,730,"PSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCS"],[734,770,"ARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCE"],[771,808,"LLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQ"],[810,847,"DVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCD"],[849,885,"DINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCA"],[887,922,"DVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCE"],[924,960,"DLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQ"],[962,998,"EADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQ"],[1000,1034,"LVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCD"],[1036,1082,"RSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCE"],[1084,1120,"EVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCE"],[1122,1158,"DVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCE"],[1160,1203,"NEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCE"],[1205,1244,"DINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQ"],[1246,1287,"VLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCE"],[1289,1325,"VARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCR"],[1335,1373,"SNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCE"]]},{"c":"x[ND]xxDxx[GE]x[TS][PA]LxφA[AVS](x){6,23}φxxx[LI]ψ(x){1,2}xxA[DN]","u":"33-50","sp":"tandem","x":"structured_like","cf":"high","why":"6 head-to-tail tandem structured repeats (residues 1782-1997; 33-34 aa for copies 2-6 and 50 aa for copy 1 due to an acidic loop insertion) anchored by [ND]xxD, [GE]x[TS][PA]LxφA, a hydrophobic [LI]ψ core, and C-terminal A[DN].","i":[[1782,1831,"VNVRGPDGFTPLMLASFCGGALEPMPTEEDEADDTSASIISDLICQGAQL"],[1832,1864,"GARTDRTGETALHLAARYARADAAKRLLDAGAD"],[1865,1898,"TNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTD"],[1899,1931,"LDARMADGSTALILAARLAVEGMVEELIASHAD"],[1932,1964,"VNAVDELGKSALHWAAAVNNVEATLALLKNGAN"],[1965,1997,"KDMQDSKEETPLFLAAREGSYEAAKLLLDHFAN"]]},{"c":"C(x){4,7}CxxxxxxxRCDxxC[NS]xxxC[GL]ΩD[GN]xDC","u":"31-34","sp":"periodic","x":"structured_like","cf":"high","why":"3 periodic 6-cysteine structured repeats (residues 1387-1500, separated by 8-10 aa linkers) with strictly conserved spacing across C2-C6 and invariant RCD and [GL]ΩD[GN]xDC motifs.","i":[[1387,1417,"CPRAACQAKRGDQRCDRECNSPGCGWDGGDC"],[1428,1458,"CEALQCWRLFNNSRCDPACSSPACLYDNFDC"],[1467,1500,"CNPVYEKYCADHFADGRCDQGCNTEECGWDGLDC"]]}],"s":"MGPGARGRRRRRRPMSPPPPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECGWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAHGQAMVFPYHRPSPGSEPRARRELAPEVIGSVVMLEIDNRLCLQSPENDHCFPDAQSAADYLGALSAVERLDFPYPLRDVRGEPLEPPEPSVPLLPLLVAGAVLLLVILVLGVMVARRKREHSTLWFPEGFSLHKDVASGHKGRREPVGQDALGMKNMAKGESLMGEVATDWMDTECPEAKRLKVEEPGMGAEEAVDCRQWTQHHLVAADIRVAPAMALTPPQGDADADGMDVNVRGPDGFTPLMLASFCGGALEPMPTEEDEADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQPSGPRSPPGPHGLGPLLCPPGAFLPGLKAAQSGSKKSRRPPGKAGLGPQGPRGRGKKLTLACPGPLADSSVTLSPVDSLDSPRPFGGPPASPGGFPLEGPYAAATATAVSLAQLGGPGRAGLGRQPPGGCVLSLGLLNPVAVPLDWARLPPPAPPGPSFLLPLAPGPQLLNPGTPVSPQERPPPYLAVPGHGEEYPAAGAHSSPPKARFLRVPSEHPYLTPSPESPEHWASPSPPSLSDWSESTPSPATATGAMATTTGALPAQPLPLSVPSSLAQAQTQLGPQPEVTPKRQVLA"},{"id":"SEQ_04430","a":"Q8NEN0","g":"ARMC2","d":"Armadillo repeat-containing protein 2","L":867,"m":[{"c":"xxxxxψφxxxxxφφNψx(x){9,12}xxxxxφxxφφxxφxx","u":"41-44","sp":"tandem","x":"structured_like","cf":"high","why":"Eight ~41-44 aa helical repeats across the C-terminal structured core featuring a conserved hydrophobic helix with an Asn-Leu signature (ψφxxxxxφφNψx) followed by an amphipathic C-terminal helix (φxxφφxxφxx). Copies are arranged head-to-tail (0-2 aa gaps) except for a single 26-aa loop insertion between copies 3 and 4.","i":[[443,485,"NSGHLLVQVTATLRNLVDSSLVRSKFLNISALPQLCTAMEQYK"],[486,528,"GDKDVCTNIARIFSKLTSYRDCCTALASYSRCYALFLNLINKY"],[529,572,"QKKQDLVVRVVFILGNLTAKNNQAREQFSKEKGSIQTLLSLFQT"],[599,641,"EAEDVLIKLTRVLANIAIHPGVGPVLAANPGIVGLLLTTLEYK"],[644,686,"DDCEELVINATATINNLSYYQVKNSIIQDKKLYIAELLLKLLV"],[688,728,"NNMDGILEAVRVFGNLSQDHDVCDFIVQNNVHRFMMALLDA"],[729,771,"QHQDICFSACGVLLNLTVDKDKRVILKEGGGIKKLVDCLRDLG"],[772,814,"PTDWQLACLVCKTLWNFSENITNASSCFGNEDTNTLLLLLSSF"]]}],"s":"MLSPNDKMLGKLDPFYQPSVSKQKTSAEIISEARNALRTVRTQRPFTPQEAQRKLFGPASSRTSENRPPSSFSLHASSFESSDSRPISGTRLSPLELKPKVPASPTREEDSCFSFPKPPVDPAKIRRVSNARARLFRAASQRALLPDRSLPPSDSKKTVESKETVMMGDSMVKINGIYLTKSNAICHLKSHPLQLTDDGGFSEIKEQEMFKGTTSLPSHLKNGGDQGKRHARASSCPSSSDLSRLQTKAVPKADLQEEDAEIEVDEVFWNTRIVPILRELEKEENIETVCAACTQLHHALEEGNMLGNKFKGRSILLKTLCKLVDVGSDSLSLKLAKIILALKVSRKNLLNVCKLIFKISRNEKNDSLIQNDSILESLLEVLRSEDLQTNMEAFLYCMGSIKFISGNLGFLNEMISKGAVEILINLIKQINENIKKCGTFLPNSGHLLVQVTATLRNLVDSSLVRSKFLNISALPQLCTAMEQYKGDKDVCTNIARIFSKLTSYRDCCTALASYSRCYALFLNLINKYQKKQDLVVRVVFILGNLTAKNNQAREQFSKEKGSIQTLLSLFQTFHQLDLHSQKPVGQRGEQHRAQRPPSEAEDVLIKLTRVLANIAIHPGVGPVLAANPGIVGLLLTTLEYKSLDDCEELVINATATINNLSYYQVKNSIIQDKKLYIAELLLKLLVSNNMDGILEAVRVFGNLSQDHDVCDFIVQNNVHRFMMALLDAQHQDICFSACGVLLNLTVDKDKRVILKEGGGIKKLVDCLRDLGPTDWQLACLVCKTLWNFSENITNASSCFGNEDTNTLLLLLSSFLDEELALDGSFDPDLKNYHKLHWETEFKPVAQQLLNRIQRHHTFLEPLPIPSF"},{"id":"SEQ_04437","a":"Q9BSJ8","g":"ESYT1","d":"Extended synaptotagmin-1","L":1104,"m":[{"c":"[IAV]x[LR]xxφφ(x){2,4}[RQE][GDK]L(x){8,17}P[YMV][AV]x[LV]xψ(x){15,20}Px[WF]xEx[YFA]xφxψ(x){5,7}[QER]x[LI]-[VL][EQS]V(x){18,26}LD(x){15,22}L","u":"116-121","sp":"dispersed","x":"structured_like","cf":"high","why":"Five ~116-121 aa structured repeat units distributed across the C-terminal ~770 residues, anchored by an N-terminal hydrophobic strand ([IAV]x[LR]xxφφ...L), central P[YMV][AV]x[LV]xψ and Px[WF]xEx[YFA]xφxψ motifs, an acidic-hydrophobic [QER]x[LI]-[VL][EQS]V strand, and a conserved C-terminal LD...L segment. Units 1+2 and 3+4 also show higher-order pairwise similarity separated by 28-59 aa linkers.","i":[[330,449,"IIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEELNPQWGETYEVMVHEVPGQEIEVEVFDKDPDKDDFLGRMKLDVGKVLQASVLDDWFPLQGGQGQVHLRLEWL"],[478,596,"AILVVYLDRAQDLPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQVKDDSRALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLYMKLVMRIL"],[648,768,"VLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIVTSVPGQELEVEVFDKDLDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDVPSGRLHLRLERL"],[798,913,"ALLSIYMERAEDLPLRKGTKHLSPYATLTVGDSSHKTKTISQTSAPVWDESASFLIRKPHTESLELQVRGEGTGVLGSLSLPLSELLVADQLCLDRWFTLSSGQGQVLLRAQLGIL"],[975,1095,"VKLTLWYYSEERKLVSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNRGTKRRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQGVARWYDL"]]}],"s":"MERSPGEGPSPSPMDQPSAPSDPTDQPPAAHAKPDPGSGGQPAGPGAAGEALAVLTSFGRRLLVLIPVYLAGAVGLSVGFVLFGLALYLGWRRVRDEKERSLRAARQLLDDEEQLTAKTLYMSHRELPAWVSFPDVEKAEWLNKIVAQVWPFLGQYMEKLLAETVAPAVRGSNPHLQTFTFTRVELGEKPLRIIGVKVHPGQRKEQILLDLNISYVGDVQIDVEVKKYFCKAGVKGMQLHGVLRVILEPLIGDLPFVGAVSMFFIRRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSIAAFLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEELNPQWGETYEVMVHEVPGQEIEVEVFDKDPDKDDFLGRMKLDVGKVLQASVLDDWFPLQGGQGQVHLRLEWLSLLSDAEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRAQDLPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQVKDDSRALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLYMKLVMRILYLDSSEICFPTVPGCPGAWDVDSENPQRGSSVDAPPRPCHTTPDSQFGTEHVLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIVTSVPGQELEVEVFDKDLDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDVPSGRLHLRLERLTPRPTAAELEEVLQVNSLIQTQKSAELAAALLSIYMERAEDLPLRKGTKHLSPYATLTVGDSSHKTKTISQTSAPVWDESASFLIRKPHTESLELQVRGEGTGVLGSLSLPLSELLVADQLCLDRWFTLSSGQGQVLLRAQLGILVSQHSGVEAHSHSYSHSSSSLSEEPELSGGPPHITSSAPELRQRLTHVDSPLEAPAGPLGQVKLTLWYYSEERKLVSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNRGTKRRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQGVARWYDLMDNKDKGSS"},{"id":"SEQ_04439","a":"Q641Q2","g":"WASHC2A","d":"WASH complex subunit 2A","L":1341,"m":[{"c":"x[LI]Fx--","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Twelve dispersed 6-residue motifs across the long central and C-terminal disordered regions featuring an invariant [LI]F hydrophobic-aromatic dipeptide followed by a polar/acidic spacer (D/E/G/S) and a conserved di-acidic (D/E) pair.","i":[[366,371,"GLFDDE"],[449,454,"GLFDDD"],[481,486,"DIFGDE"],[536,541,"GLFSDE"],[571,576,"SLFDDE"],[663,668,"SLFEED"],[689,694,"LLFEDD"],[725,730,"LLFSDE"],[802,807,"SLFDEE"],[877,882,"SLFGDD"],[1233,1238,"DIFEDD"],[1289,1294,"SIFDDD"]]},{"c":"-[EDS][EDS][DN]LF","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Seven non-overlapping 6-residue acidic-LF motifs in the disordered region comprising an N-terminal acidic/polar tract followed by [DN]LF; five copies occur immediately downstream of x[LI]Fx-- instances to form paired x[LI]F-acidic-[DN]LF modules.","i":[[336,341,"EEDNLF"],[373,378,"EESDLF"],[543,548,"DSEDLF"],[578,583,"EEDNLF"],[669,674,"EEDDLF"],[883,888,"EDDDLF"],[1204,1209,"DEDDLF"]]}],"s":"MMNRTTPDQELAPASEPVWERPWSVEEIRRSSQSWSLAADAGLLQFLQEFSQQTISRTHEIKKQVDGLIRETKATDCRLHNVFNDFLMLSNTQFIENRVYDEEVEEPVLKAEAEKTEQEKTREQKEVDLIPKVQEAVNYGLQVLDSAFEQLDIKAGNSDSEEDDANGRVELILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIVDTEEEKEEEESDEDFAHHSDNEQNRHTTQMSDEEEDDDGCDLFADSEKEEEDIEDIEENTRPKRSRPTSFADELAARIKGDAVGRVDEEPTTLPSGEAKPRKTLKEKKERRTPSDDEEDNLFAPPKLTDEDFSPFGSGGGLFSGGKGLFDDEDEESDLFTEAPQDRQAGASVKEESSSSKPGKKIPAGAVSVFLGDTDVFGAASVPSMKEPQKPEQPTPRKSPYGPPPTGLFDDDDGDDDDDFFSAPHSKPSKTGKVQSTADIFGDEEGDLFKEKAVASPEATVSQTDENKARAEKKVTLSSSKNLKPSSETKTQKGLFSDEEDSEDLFSSQSASKLKGASLLPGKLPTLVSLFDDEDEEDNLFGGTAAKKQTLCLQAQREEKAKASELSKKKASALLFSSDEEDQWNIPASQTHLASDSRSKGEPRDSGTLQSQEAKAVKKTSLFEEDEEDDLFAIAKDSQKKTQRVSLLFEDDVDSGGSLFGSPPTSVPPATKKKETVSEAPPLLFSDEEEKEAQLGVKSVDKKVESAKESLKFGRTDVAESEKEGLLTRSAQETVKHSDLFSSSSPWDKGTKPRTKTVLSLFDEEEDKMEDQNIIQAPQKEVGKGRDPDAHPKSTGVFQDEELLFSHKLQKDNDPDVDLFAGTKKTKLLEPSVGSLFGDDEDDDLFSSAKSQPLVQEKKRVVKKDHSVDSFKNQKHPESIQGSKEKGIWKPETPQDSSGLAPFKTKEPSTRIGKIQANLAINPAALLPTAASQISEVKPVLPELAFPSSEHRRSHGLESVPVLPGSGEAGVSFDLPAQADTLHSANKSRVKMRGKRRPQTRAARRLAAQESSETEDMSVPRGPIAQWADGAISPNGHRPQLRAASGEDSTEEALAAAAAPWEGGPVPGVDRSPFAKSLGHSRGEADLFDSGDIFSTGTGSQSVERTKPKAKIAENPANPPVGGKAKSPMFPALGEASSDDDLFQSAKPKPAKKTNPFPLLEDEDDLFTDQKVKKNETKSNSQQDVILTTQDIFEDDIFATEAIKPSQKTREKEKTLESNLFDDNIDIFADLTVKPKEKSKKKVEAKSIFDDDMDDIFSSGIQAKTTKPKSRSAQAAPEPRFEHKVSNIFDDPLNAFGGQ"},{"id":"SEQ_04442","a":"O96028","g":"NSD2","d":"Histone-lysine N-methyltransferase NSD2","L":1365,"m":[{"c":"CxxC(x){8,9}C(x){2,4}Cxx[AF][FY]HxxC[LV](x){8,12}[FW]xC(x){2,4}C","u":"39-48","sp":"dispersed","x":"structured_like","cf":"high","why":"Four cysteine/histidine-rich C4HC3 structural repeats (two closely spaced at 670-764 and two dispersed at 835-873 and 1243-1286) sharing invariant Zn-coordinating C/H spacing, a conserved Cxx[AF][FY]HxxC[LV] core knuckle, and a C-terminal [FW]xC(x){2,4}C anchor.","i":[[670,710,"CQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSEC"],[717,764,"CFVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSC"],[834,872,"CFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDC"],[1242,1285,"CFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHC"]]},{"c":"DψψWxKψ[GS][GN]Y[PR]WWPxxV(x){10,11}K[LM]K(x){9,12}FFG(x){5,6}W","u":"49-52","sp":"dispersed","x":"structured_like","cf":"high","why":"Two long (~50 aa) dispersed aromatic-rich structural domain repeats anchored by an N-terminal DψψWxKψxxY[PR]WWPxxV signature, an internal K[LM]K basic triplet, and a C-terminal FFG(x){5,6}W motif.","i":[[224,275,"DLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAW"],[882,930,"DIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYW"]]}],"s":"MEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVFNGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDSLLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVSMPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTEDAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENEVSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSTTLSSEEKGKKTKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGRSYCCEHDLGAASVRSTKTEKPPPEPGKPKGKRRRRRGWRRVTEGK"},{"id":"SEQ_04446","a":"P39880","g":"CUX1","d":"Homeobox protein cut-like 1","L":1505,"m":[{"c":"DTφ[EG]ψ[AT]+[QR]VKExLxx[HN][GN]ψ[CG]QRψFG[EH]xψLGL[ST]QGSVS-ψL[AS]RPKPW[HNS]KL[ST]x+G+EPFx+M[KQ][LQ]ΩL[NS]","u":64,"sp":"dispersed","x":"structured_like","cf":"high","why":"Three strongly conserved 64-aa domain repeats dispersed across the middle and C-terminal halves, anchored by invariant DT, VKE, QRψFG, LGL[ST]QGSVS, RPKPW, G+EPF, and M[KQ][LQ]ΩL motifs.","i":[[552,615,"DTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLS"],[944,1007,"DTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLN"],[1127,1190,"DTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLN"]]},{"c":"SD-AI+SIL[EQ]QA+REψ[EQ][AV]Q","u":19,"sp":"dispersed","x":"mixed","cf":"medium","why":"Two closely spaced 19-aa internal duplications separated by a 16-aa P/S/G-rich linker, sharing 11 identical anchor positions (SD, AI, SIL, QA, RE, Q) and 6 conservative substitutions.","i":[[667,685,"SDEAIKSILEQAKRELQVQ"],[702,720,"SDDAIRSILQQARREMEAQ"]]}],"s":"MLCVAGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESRRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIRSILQQARREMEAQQAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPNPPALKKEAQDAPGLDPQGAADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEEAKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGASRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPPIEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSGRAAPSSEGDSCDGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPSGTPGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAPGEGPAAPSSAPPPSNSSSSSAPRRPSSLQSLFGLPEAAGARDSRDNPLRKKKAANLNSIIHRLEKAASREEPIEWEF"},{"id":"SEQ_04454","a":"Q9C0K0","g":"BCL11B","d":"B-cell lymphoma/leukemia 11B","L":894,"m":[{"c":"xxCxxCxxx[CF]xxx[SW]xLxxH(x){3,4}H","u":"23-24","sp":"dispersed","x":"structured_like","cf":"high","why":"Six 23-24 aa Cys2-His2 repeat units (one isolated copy plus two-copy and three-copy clusters, with copies 2-3 and 4-5 forming a highly conserved duplicated pair) defined by invariant CxxC, [CF], L, and H(x){3,4}H anchors.","i":[[221,244,"YICTTCKQPFNSAWFLLQHAQNTH"],[427,449,"KSCEFCGKTFKFQSNLIVHRRSH"],[455,477,"YKCQLCDHACSQASKLKRHMKTH"],[796,818,"DTCEYCGKVFKNCSNLTVHRRSH"],[824,846,"YKCELCNYACAQSSKLTRHMKTH"],[854,877,"YRCDICQMPFSVYSTLEKHMKKWH"]]}],"s":"MSRRKQGNPQHLSQRELITPEADHVEAAILEEDEGLEIEEPSGLGLMVGGPDPDLLTCGQCQMNFPLGDILVFIEHKRKQCGGSLGACYDKALDKDSPPPSSRSELRKVSEPVEIGIQVTPDEDDHLLSPTKGICPKQENIAGPCRPAQLPAVAPIAASSHPHSSVITSPLRALGALPPCLPLPCCSARPVSGDGTQGEGQTEAPFGCQCQLSGKDEPSSYICTTCKQPFNSAWFLLQHAQNTHGFRIYLEPGPASSSLTPRLTIPPPLGPEAVAQSPLMNFLGDSNPFNLLRMTGPILRDHPGFGEGRLPGTPPLFSPPPRHHLDPHRLSAEEMGLVAQHPSAFDRVMRLNPMAIDSPAMDFSRRLRELAGNSSTPPPVSPGRGNPMHRLLNPFQPSPKSPFLSTPPLPPMPPGGTPPPQPPAKSKSCEFCGKTFKFQSNLIVHRRSHTGEKPYKCQLCDHACSQASKLKRHMKTHMHKAGSLAGRSDDGLSAASSPEPGTSELAGEGLKAADGDFRHHESDPSLGHEPEEEDEEEEEEEEELLLENESRPESSFSMDSELSRNRENGGGGVPGVPGAGGGAAKALADEKALVLGKVMENVGLGALPQYGELLADKQKRGAFLKRAAGGGDAGDDDDAGGCGDAGAGGAVNGRGGGFAPGTEPFPGLFPRKPAPLPSPGLNSAAKRIKVEKDLELPPAALIPSENVYSQWLVGYAASRHFMKDPFLGFTDARQSPFATSSEHSSENGSLRFSTPPGDLLDGGLSGRSGTASGGSTPHLGGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQIGKEVYRCDICQMPFSVYSTLEKHMKKWHGEHLLTNDVKIEQAERS"},{"id":"SEQ_04456","a":"C9JTQ0","g":"ANKRD63","d":"Ankyrin repeat domain-containing protein 63","L":380,"m":[{"c":"[GS]x[TV][PAM][LW]xφA[CVA](x){2,8}[GAL]xx[VL][QRE]φL[VLT]x","u":"20-26","sp":"periodic","x":"structured_like","cf":"high","why":"Four periodic ~35-residue structured repeats in the N-terminal half share a conserved N-terminal [GS]x[TV][PAM][LW]xφA[CVA] segment and a C-terminal [GAL]xx[VL][QRE]φL[VLT]x helix separated by a short 2-8 residue turn (often ending in GH) and regular 11-15 residue linkers.","i":[[47,72,"GRTPLMVAVGLPDPALRARFVRLLLE"],[84,105,"GRTALSLACERGHLDAVQLLVQ"],[119,138,"SPVMWAAACGHGAVLEFLVR"],[154,175,"GLTALQLAAARGHGTCVQALTG"]]}],"s":"MLKPKDLCPRAGTRTFLEAMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARGHGTCVQALTGPWGRAAAAAAARGSNSDSPPGRPAPAASPEHRRPSPRRLPRPLLARFARAAGGHGGEAGSAGKNSGRHRAQGSERPELGRSMSLALGAVTEEEAARLRAGALMALPNSPQSSGTGRWRSQEVLEGAPPTLAQAPIGLSPHPEGGPGSGRLGLRRRSTAPDIPSLVGEAPGPESGPELEANALSVSVPGPNPWQAGTEAVVLRAQR"},{"id":"SEQ_04459","a":"Q92997","g":"DVL3","d":"Segment polarity protein dishevelled homolog DVL-3","L":716,"m":[{"c":"[YM]GPP[GM][VLA][PM][PM]","u":8,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three 8-residue copies in the C-terminal proline-rich disordered tail share a fixed GPP core anchored N-terminally by [YM] and followed by [GM], a conserved aliphatic residue [VLA], and [PM][PM], separated by 1- and 6-residue linkers.","i":[[653,660,"YGPPGVPP"],[662,669,"YGPPMLMM"],[676,683,"MGPPGAPP"]]}],"s":"MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPDPAPFCADNPSELPPPMERTGGIGDSRPPSFHPHAGGGSQENLDNDTETDSLVSAQRERPRRRDGPEHATRLNGTAKGERRREPGGYDSSSTLMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFPAYGMSPSLSTITSTSSSITSSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSSGASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSYGGGSASSQHSEGSRSSGSNRSGSDRRKEKDPKAGDSKSGGSGSESDHTTRSSLRGPRERAPSERSGPAASEHSHRSHHSLASSLRSHHTHPSYGPPGVPPLYGPPMLMMPPPPAAMGPPGAPPGRDLASVPPELTASRQSFRMAMGNPSEFFVDVM"},{"id":"SEQ_04464","a":"O15060","g":"ZBTB39","d":"Zinc finger and BTB domain-containing protein 39","L":712,"m":[{"c":"Cx[VAL]C(x){12,13}HxxxH","u":"21-22","sp":"dispersed","x":"structured_like","cf":"high","why":"Nine 21-22 residue repeats across the C-terminal half exhibit invariant CxxC and HxxxH chelating anchors with a conserved aliphatic position Cx[VAL]C and a 12-13 residue central segment enriched in aromatic/aliphatic core positions, arranged in three clusters separated by 7-9 aa intra-cluster and 46-58 aa inter-cluster linkers.","i":[[345,366,"CQVCKKVLEPNIQLIRQHARDH"],[374,394,"CKVCETHFQDRNSRVTHVLSH"],[453,474,"CAACGKVLAKDFHVVRGHILDH"],[482,502,"CSVCDQRHLNLCSLMWHTLSH"],[510,530,"CSVCANSFVDWHLLEKHMAVH"],[540,560,"CRLCSQSFKSEAAYRYHVSQH"],[607,627,"CKVCGKRFAHTSEFNYHRRIH"],[635,655,"CKVCHKFFRGRSTIKCHLKTH"],[663,683,"CTVCGHYSSTLNLMSKHVGVH"]]}],"s":"MGMRIKLQSTNHPNNLLKELNKCRLSETMCDVTIVVGSRSFPAHKAVLACAAGYFQNLFLNTGLDAARTYVVDFITPANFEKVLSFVYTSELFTDLINVGVIYEVAERLGMEDLLQACHSTFPDLESTARAKPLTSTSESHSGTLSCPSAEPAHPLGELRGGGDYLGADRNYVLPSDAGGSYKEEEKNVASDANHSLHLPQPPPPPPKTEDHDTPAPFTSIPSMMTQPLLGTVSTGIQTSTSSCQPYKVQSNGDFSKNSFLTPDNAVDITTGTNSCLSNSEHSKDPGFGQMDELQLEDLGDDDLQFEDPAEDIGTTEEVIELSDDSEDELAFGENDNRENKAMPCQVCKKVLEPNIQLIRQHARDHVDLLTGNCKVCETHFQDRNSRVTHVLSHIGIFLFSCDMCETKFFTQWQLTLHRRDGIFENNIIVHPNDPLPGKLGLFSGAASPELKCAACGKVLAKDFHVVRGHILDHLNLKGQACSVCDQRHLNLCSLMWHTLSHLGISVFSCSVCANSFVDWHLLEKHMAVHQSLEDALFHCRLCSQSFKSEAAYRYHVSQHKCNSGLDARPGFGLQHPALQKRKLPAEEFLGEELALQGQPGNSKYSCKVCGKRFAHTSEFNYHRRIHTGEKPYQCKVCHKFFRGRSTIKCHLKTHSGALMYRCTVCGHYSSTLNLMSKHVGVHKGSLPPDFTIEQTFMYIIHSKEADKNPDS"},{"id":"SEQ_04474","a":"P20396","g":"TRH","d":"Pro-thyrotropin-releasing hormone","L":242,"m":[{"c":"KRQHPG[KR]R","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Six highly conserved dispersed 8-aa motifs sharing an invariant KRQHPG core followed by a dibasic [KR]R dibasic cleavage/recognition-like anchor across a disordered acidic/polar C-terminal region.","i":[[82,89,"KRQHPGKR"],[112,119,"KRQHPGRR"],[133,140,"KRQHPGRR"],[150,157,"KRQHPGRR"],[184,191,"KRQHPGKR"],[225,232,"KRQHPGRR"]]}],"s":"MPGPWLLLALALTLNLTGVPGGRAQPEAAQQEAVTAAEHPGLDDFLRQVERLLFLRENIQRLQGDQGEHSASQIFQSDWLSKRQHPGKREEEEEEGVEEEEEEEGGAVGPHKRQHPGRREDEASWSVDVTQHKRQHPGRRSPWLAYAVPKRQHPGRRLADPKAQRSWEEEEEEEEREEDLMPEKRQHPGKRALGGPCGPQGAYGQAGLLLGLLDDLSRSQGAEEKRQHPGRRAAWVREPLEE"},{"id":"SEQ_04475","a":"P50552","g":"VASP","d":"Vasodilator-stimulated phosphoprotein","L":380,"m":[{"c":"GPPPPP","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four exact 6-aa GPPPPP units within the central proline-rich disordered region, comprising one N-terminal copy and a 3-copy head-to-tail tandem array (GPPPPPGPPPPPGPPPPP) flanked by two single-substitution variants (GPPAPP, GPPPAP).","i":[[117,122,"GPPPPP"],[169,174,"GPPPPP"],[175,180,"GPPPPP"],[181,186,"GPPPPP"]]}],"s":"MSETVICSSRATVMLYDDGNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQQVVINCAIVRGVKYNQATPNFHQWRDARQVWGLNFGSKEDAAQFAAGMASALEALEGGGPPPPPALPTWSVPNGPSPEEVEQQKRQQPGPSEHIERRVSNAGGPPAPPAGGPPPPPGPPPPPGPPPPPGLPPSGVPAAAHGAGGGPPPAPPLPAAQGPGGGGAGAPGLAAAIAGAKLRKVSKQEEASGGPTAPKAESGRSGGGGLMEEMNAMLARRRKATQVGEKTPKDESANQEEPEARVPAQSESVRRPWEKNSTTLPRMKSSSSVTTSETQPCTPSSSDYSDLQRVKQELLEEVKKELQKVKEEIIEAFVQELRKRGSP"},{"id":"SEQ_04478","a":"O75182","g":"SIN3B","d":"Paired amphipathic helix protein Sin3b","L":1162,"m":[{"c":"[TS]Ωφ[DN][QK][VI]+x[RV][FL]x[SD](x){3,4}YxxFLxxψxxΩ(x){13,23}V[SA]x[LF][FL]xxx[PE]-LφxxFxxFL[PG]","u":"59-70","sp":"dispersed","x":"structured_like","cf":"high","why":"Three N-terminal globular repeat domains (~59-70 aa separated by ~60-73 aa linkers) share two strongly conserved amphipathic helical subdomains anchored by [TS]Ωφ[DN], YxxFLxxψxxΩ, and V[SA]x[LF][FL]xxx[PE]-LφxxFxxFL[PG] across a variable central loop.","i":[[46,105,"TYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLFHEHPDLIVGFNAFLP"],[167,236,"SYVNKIKTRFLDHPEIYRSFLEILHTYQKEQLNTRGRPFRGMSEEEVFTEVANLFRGQEDLLSEFGQFLP"],[309,367,"SFFDKVRRVLKSQEVYENFLRCIALFNQELVSGSELLQLVSPFLGKFPELFAQFKSFLG"]]}],"s":"MAHAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLPVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLFHEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQSPLTSQENSHNHGDGAEDFKQQVPYKEDKPQVPLESDSVEFNNAISYVNKIKTRFLDHPEIYRSFLEILHTYQKEQLNTRGRPFRGMSEEEVFTEVANLFRGQEDLLSEFGQFLPEAKRSLFTGNGPCEMHSVQKNEHDKTPEHSRKRSRPSLLRPVSAPAKKKMKLRGTKDLSIAAVGKYGTLQEFSFFDKVRRVLKSQEVYENFLRCIALFNQELVSGSELLQLVSPFLGKFPELFAQFKSFLGVKELSFAPPMSDRSGDGISREIDYASCKRIGSSYRALPKTYQQPKCSGRTAICKELDHWTLLQGSWTDDYCMSKFKNTCWIPGYSAGVLNDTWVSFPSWSEDSTFVSSKKTPYEEQLHRCEDERFELDVVLETNLATIRVLESVQKKLSRMAPEDQEKFRLDDSLGGTSEVIQRRAIYRIYGDKAPEIIESLKKNPVTAVPVVLKRLKAKEEEWREAQQGFNKIWREQYEKAYLKSLDHQAVNFKQNDTKALRSKSLLNEIESVYDEHQEQHSEGRSAPSSEPHLIFVYEDRQILEDAAALISYYVKRQPAIQKEDQGTIHQLLHQFVPSLFFSQQLDLGASEESADEDRDSPQGQTTDPSERKKPAPGPHSSPPEEKGAFGDAPATEQPPLPPPAPHKPLDDVYSLFFANNNWYFFLRLHQTLCSRLLKIYRQAQKQLLEYRTEKEREKLLCEGRREKGSDPAMELRLKQPSEVELEEYYPAFLDMVRSLLEGSIDPTQYEDTLREMFTIHAYVGFTMDKLVQNIARQLHHLVSDDVCLKVVELYLNEKKRGAAGGNLSSRCVRAARETSYQWKAERCMADENCFKVMFLQRKGQVIMTIELLDTEEAQTEDPVEVQHLARYVEQYVGTEGASSSPTEGFLLKPVFLQRNLKKFRRRWQSEQARALRGEARSSWKRLVGVESACDVDCRFKLSTHKMVFIVNSEDYMYRRGTLCRAKQVQPLVLLRHHQHFEEWHSRWLEDNVTVEAASLVQDWLMGEEDEDMVPCKTLCETVHVHGLPVTRYRVQYSRRPASP"},{"id":"SEQ_04489","a":"Q7Z434","g":"MAVS","d":"Mitochondrial antiviral-signaling protein","L":540,"m":[{"c":"φPSK[VL]P[TI]o","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four non-overlapping copies of an 8-residue proline-anchored motif in the central disordered region share an invariant PSK[VL]P core flanked by N-terminal non-proline hydrophobic (L/V/A) and C-terminal [TI] + polar uncharged (T/S/N) positions.","i":[[294,301,"LPSKVPTT"],[322,329,"VPSKLPTS"],[345,352,"APSKLPIN"],[359,366,"VPSKVPTS"]]}],"s":"MPFAEDKTYKYICRNFSNFCNVDVVEILPYLPCLTARDQDRLRATCTLSGNRDTLWHLFNTLQRRPGWVEYFIAALRGCELVDLADEVASVYQSYQPRTSDRPPDPLEPPSLPAERPGPPTPAAAHSIPYNSCREKEPSYPMPVQETQAPESPGENSEQALQTLSPRAIPRNPDGGPLESSSDLAALSPLTSSGHQEQDTELGSTHTAGATSSLTPSRGPVSPSVSFQPLARSTPRASRLPGPTGSVVSTGTSFSSSSPGLASAGAAEGKQGAESDQAEPIICSSGAEAPANSLPSKVPTTLMPVNTVALKVPANPASVSTVPSKLPTSSKPPGAVPSNALTNPAPSKLPINSTRAGMVPSKVPTSMVLTKVSASTVPTDGSSRNEETPAAPTPAGATGGSSAWLDSSSENRGLGSELSKPGVLASQVDSPFSGCFEDLAISASTSLGMGPCHGPEENEYKSEGTFGIHVAENPSIQLLEGNPGPPADPDGGPRPQADRKFQEREVPCHRPSPGALWLQVAVTGVLVVTLLVVLYRRRLH"},{"id":"SEQ_04497","a":"Q8WV28","g":"BLNK","d":"B-cell linker protein","L":456,"m":[{"c":"[DES]xxY[EVI]xPx[EV]","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five dispersed copies of an acidic YxxP motif in the N-terminal disordered region (clustered in two blocks of three and two copies), anchored by invariant Y4 and P7, acidic/polar N-terminal flank [DES]1, [EVI]5, and conserved E9 in four of five copies.","i":[[69,77,"DSDYENPDE"],[81,89,"SEMYVMPAE"],[93,101,"DDSYEPPPV"],[175,183,"EADYVVPVE"],[186,194,"DENYIHPTE"]]}],"s":"MDKLNKITVPASQKLRQLQKMVHDIKNNEGGIMNKIKKLKVKAPPSVPRRDYASESPADEEEQWSDDFDSDYENPDEHSDSEMYVMPAEENADDSYEPPPVEQETRPVHPALPFARGEYIDNRSSQRHSPPFSKTLPSKPSWPSEKARLTSTLPALTALQKPQVPPKPKGLLEDEADYVVPVEDNDENYIHPTESSSPPPEKAPMVNRSTKPNSSTPASPPGTASGRNSGAWETKSPPPAAPSPLPRAGKKPTTPLKTTPVASQQNASSVCEEKPIPAERHRGSSHRQEAVQSPVFPPAQKQIHQKPIPLPRFTEGGNPTVDGPLPSFSSNSTISEQEAGVLCKPWYAGACDRKSAEEALHRSNKDGSFLIRKSSGHDSKQPYTLVVFFNKRVYNIPVRFIEATKQYALGRKKNGEEYFGSVAEIIRNHQHSPLVLIDSQNNTKDSTRLKYAVKVS"},{"id":"SEQ_04504","a":"A6NC78","g":"GOLGA8IP","d":"Putative golgin subfamily A member 8I","L":632,"m":[{"c":"QEER[IL][RQ][EK]","u":7,"sp":"tandem","x":"structured_like","cf":"medium","why":"Three head-to-tail 7-aa copies embedded within the extended coiled-coil domain that share a highly conserved sequence-level core (invariant QEER1-4, aliphatic [IL]5, polar/basic [RQ]6, and charged [EK]7) well beyond generic heptad periodicity.","i":[[339,345,"QEERIRE"],[346,352,"QEERLRK"],[353,359,"QEERIQE"]]}],"s":"MAEETQHNKLAAAKKKLKEYWQKNSPRVPAGANRNRKTNGSIPQTATSGGCQPPGDSATGFHREGPTSSATLKDLESPCQERAVVLDSRSVEISQLKNTIKSLKQQKKQVEHQLEEEKKANIKKQKAKRVLEVQIQTLNIQKEELNTDLYHMKRSLRYFEEKSKDLAVRLQHSLQRKGELESVLSDVMATQKKKANQLSSPSKAGTEWKLEQSMREEALLKVQLTQLKESFQQLQLERHEYAEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGALQAQVKNNQRISLLNRGQEERIREQEERLRKQEERIQEQHKSLQQLAKPQSVFEEPNNENKSALQLEQQVKELQEKLGEEHLEAASQQNQQLTAQLSLMALPGEGHGGEHLDSEGEEAPQPMPSVPEDLESREAMSSFMDHLEEKADLSELVKKKELCFIHHWRERCHQKTHHLLSEPGGRAKDAALGGGHHQAGAQGGDEGEAAGAAADGIAAYSNYNNGHRKFLAAAHNPADEPGPGAPAPQELGAADKHGDLCEVSLTSSAQGEAREDPLLDKPTAQPIVQDHQEHPGLGSNCCVPFFCWAWLPRRRR"},{"id":"SEQ_04506","a":"O95817","g":"BAG3","d":"BAG family molecular chaperone regulator 3","L":575,"m":[{"c":"[QE]L[PR][PR]G[YH]I[PS]I[PQ]V[LI][HR][EK]","u":14,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three strongly conserved 14-aa repeats dispersed across the central proline/polar-rich disordered region, featuring invariant L2, G5, I7, I9, and V11 anchors and tight two-residue physicochemical constraints at all remaining positions.","i":[[88,101,"QLRPGYIPIPVLHE"],[200,213,"QLPRGYISIPVIHE"],[331,344,"ELPPGHIPIQVIRK"]]}],"s":"MSAATHSPMMQVASGNGDRDPLPPGWEIKIDPQTGWPFFVDHNSRTTTWNDPRVPSEGPKETPSSANGPSREGSRLPPAREGHPVYPQLRPGYIPIPVLHEGAENRQVHPFHVYPQPGMQRFRTEAAAAAPQRSQSPLRGMPETTQPDKQCGQVAAAAAAQPPASHGPERSQSPAASDCSSSSSSASLPSSGRSSLGSHQLPRGYISIPVIHEQNVTRPAAQPSFHQAQKTHYPAQQGEYQTHQPVYHKIQGDDWEPRPLRAASPFRSSVQGASSREGSPARSSTPLHSPSPIRVHTVVDRPQQPMTHRETAPVSQPENKPESKPGPVGPELPPGHIPIQVIRKEVDSKPVSQKPPPPSEKVEVKVPPAPVPCPPPSPGPSAVPSSPKSVATEERAAPSTAPAEATPPKPGEAEAPPKHPGVLKVEAILEKVQGLEQAVDNFEGKKTDKKYLMIEEYLTKELLALDSVDPEGRADVRQARRDGVRKVQTILEKLEQKAIDVPGQVQVYELQPSNLEADQPLQAIMEMGAVAADKGKKNAGNAEDPHTETQQPEATAAATSNPSSMTDTPGNPAAP"},{"id":"SEQ_04511","a":"Q06787","g":"FMR1","d":"Fragile X messenger ribonucleoprotein 1","L":632,"m":[{"c":"Vxx[DN]LψGxφIGxxGxxIQ[QE]φxxxxGV[TV]xψxψ-x-","u":34,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 34-aa structured repeats separated by a 28-aa segment, anchored by invariant V, L, three G positions (LψGxφIGxxGxxIQ), GV, and conserved aliphatic and acidic C-terminal positions.","i":[[225,258,"VREDLMGLAIGTHGANIQQARKVPGVTAIDLDED"],[288,321,"VPRNLVGKVIGKNGKLIQEIVDKSGVVRVRIEAE"]]}],"s":"MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDINESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKPATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKRAHMLIDMHFRSLRTKLSLIMRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGANIQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKNGKLIQEIVDKSGVVRVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKENSTHFSQPNSTKVQRVLVASSVVAGESQKPELKAWQGMVPFVFVGTKDSIANATVLLDYHLNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRTDKEKSYVTDDGQGMGRGSRPYRNRGHGRRGPGYTSGTNSEASNASETESDHRDELSDWSLAPTEEERESFLRRGDGRRRGGGGRGQGGRGRGGGFKGNDDHSRTDNRPRNPREAKGRTTDGSLQIRVDCNNERSVHTKTLQNTSSEGSRLRTGKDRNQKKEKPDSVDGQQPLVNGVP"},{"id":"SEQ_04521","a":"Q96PC5","g":"MIA2","d":"Melanoma inhibitory activity protein 2","L":1412,"m":[{"c":"[GP][GP]xF[PV][GP]PP","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed 8-aa motifs in the C-terminal proline/glycine-rich disordered region anchored by an invariant central F, an N-terminal GP/PG dipeptide, and a conserved C-terminal [PV][GP]PP segment.","i":[[1296,1303,"GPGFVPPP"],[1324,1331,"GPPFPPPP"],[1345,1352,"PGDFPGPP"],[1375,1382,"PGFFPPPP"]]}],"s":"MAKFGVHRILLLAISLTKCLESTKLLADLKKCGDLECEALINRVSAMRDYRGPDCRYLNFTKGEEISVYVKLAGEREDLWAGSKGKEFGYFPRDAVQIEEVFISEEIQMSTKESDFLCLLGVSYTFDNEDSELNGDYGENIYPYEEDKDEKSSIYESDFQIEPGFYATYESTLFEDQVPALEAPEDIGSTSESKDWEEVVVESMEQDRIPEVHVPPSSAVSGVKEWFGLGGEQAEEKAFESVIEPVQESSFRSRKIAVEDENDLEELNNGEPQTEHQQESESEIDSVPKTQSELASESEHIPKPQSTGWFGGGFTSYLGFGDEDTGLELIAEESNPPLQDFPNSISSDKEATVPCTEILTEKKDTITNDSLSLKPSWFDFGFAILGFAYAKEDKIMLDDRKNEEDGGADEHEHPLTSELDPEKEQEIETIKIIETEDQIDKKPVSEKTDESDTIPYLKKFLYNFDNPWNFQNIPKETELPFPKQILDQNNVIENEETGEFSIDNYPTDNTKVMIFKSSYSLSDMVSNIELPTRIHEEVYFEPSSSKDSDENSKPSVDTEGPALVEIDRSVENTLLNSQMVSTDNSLSSQNYISQKEDASEFQILKYLFQIDVYDFMNSAFSPIVILTERVVAALPEGMRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPNTAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLDHQITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRFCSNSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEATGPGFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAPFAMRNVYPPRGFPPYLPPRPGFFPPPPHSEGRSEFPSGLIPPSNEPATEHPEPQQET"},{"id":"SEQ_04535","a":"P20810","g":"CAST","d":"Calpastatin","L":708,"m":[{"c":"xDxAψ-xLx[DA][ST]LG(x){31,32}-[EDV]TIP[PS][EDK]YR[ELH][ELK]x(x){4,5}[GD][KI][PT]xxP(x){8,13}[PED][DSQ]xxψD[AE]LS[ESG]D[FL][DST]","u":"88-93","sp":"periodic","x":"disordered_like","cf":"high","why":"Four periodic 88-93 aa tripartite disordered repeats separated by regular 46-52 aa linkers, each combining an N-terminal D..A[LV][DE].L..[ST]LG motif, a central [ED].TIP[PS][EDK]YR..P core, and a C-terminal paralogous [ILV]D[AE]LS.D[FL] motif.","i":[[153,240,"MDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT"],[287,377,"SDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFD"],[430,520,"PDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFS"],[567,659,"LDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD"]]}],"s":"MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD"},{"id":"SEQ_04557","a":"Q13574","g":"DGKZ","d":"Diacylglycerol kinase zeta","L":928,"m":[{"c":"[GS]x[ET]xx[EHQ]xAxxxxxxxψxx[LY][HIL]x(x){4,6}ψψ(x){2,3}-[DEQ][NQ]","u":"32-35","sp":"tandem","x":"structured_like","cf":"high","why":"Four head-to-tail 32-35 aa structured repeats at C-terminus (residues 791-924) anchored by invariant A, conserved aliphatic (ψ) and aromatic/aliphatic ([LY]) core positions, a C-terminal ψψ doublet, and an acidic/polar -[DEQ][NQ] cap.","i":[[791,822,"GEELIEAAKRNDFCKLQELHRAGGDLMHRDEQ"],[823,857,"SRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEEN"],[858,890,"GETCLHQAAALGQRTICHYIVEAGASLMKTDQQ"],[891,924,"GDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQ"]]},{"c":"HxWφxxxxxxxxC(x){2,6}C(x){12,19}C[AS]xCKxφφH(x){2,4}C(x){9,10}C","u":"55-59","sp":"dispersed","x":"structured_like","cf":"high","why":"Two non-overlapping cysteine/histidine-rich 55-59 aa domains in the N-terminal region separated by a 19-aa linker, sharing ten fixed H/W/C/K anchor positions (HxW...C...C...CxxCKxφφH...C...C).","i":[[98,152,"HIWFETNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRC"],[172,230,"HHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPC"]]}],"s":"MEPRDGSPEARSSDSESASASSSGSERDAGPEPDKAPRRLNKRRFPGLRLFGHRKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV"},{"id":"SEQ_04571","a":"Q13069","g":"GAGE5","d":"G antigen 5","L":117,"m":[{"c":"GPxx[PQ]E(x){3,4}[DN]xxExxTPEEGExx[ST]Q","u":"25-26","sp":"dispersed","x":"disordered_like","cf":"high","why":"Two 25-26 aa internal duplications in a proline/acidic-rich disordered sequence separated by 41 aa, sharing 11 identical anchor residues including an N-terminal GPxx[PQ]E segment and a conserved ExxTPEEGExx[ST]Q core.","i":[[25,49,"GPMRPEQFSDEVEPATPEEGEPATQ"],[91,116,"GPDGQEMDPPNPEEVKTPEEGEKQSQ"]]}],"s":"MSWRGRSTYYWPRPRRYVQPPEVIGPMRPEQFSDEVEPATPEEGEPATQRQDPAAAQEGEDEGASAGQGPKPEADSQEQGHPQTGCECEDGPDGQEMDPPNPEEVKTPEEGEKQSQC"},{"id":"SEQ_04573","a":"O60496","g":"DOK2","d":"Docking protein 2","L":412,"m":[{"c":"[AP]xxxYD[SEN][PIV]","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed copies in the C-terminal disordered region anchored by an invariant YD dipeptide, a conserved [AP] at -4, polar/acidic [SEN] at +2, and [PIV] at +3 (with the first three clustered copies also sharing aliphatic [LI] immediately preceding YD).","i":[[326,333,"ADPLYDSI"],[341,348,"PDHIYDEP"],[353,360,"ALSLYDSP"],[398,405,"PGTEYDNV"]]}],"s":"MGDGAVKQGFLYLQQQQTFGKKWRRFGASLYGGSDCALARLELQEGPEKPRRCEAARKVIRLSDCLRVAEAGGEASSPRDTSAFFLETKERLYLLAAPAAERGDWVQAICLLAFPGQRKELSGPEGKQSRPCMEENELYSSAVTVGPHKEFAVTMRPTEASERCHLRGSYTLRAGESALELWGGPEPGTQLYDWPYRFLRRFGRDKVTFSFEAGRRCVSGEGNFEFETRQGNEIFLALEEAISAQKNAAPATPQPQPATIPASLPRPDSPYSRPHDSLPPPSPTTPVPAPRPRGQEGEYAVPFDAVARSLGKNFRGILAVPPQLLADPLYDSIEETLPPRPDHIYDEPEGVAALSLYDSPQEPRGEAWRRQATADRDPAGLQHVQPAGQDFSASGWQPGTEYDNVVLKKGPK"},{"id":"SEQ_04577","a":"Q92585","g":"MAML1","d":"Mastermind-like protein 1","L":1016,"m":[{"c":"QxQ[QKR][HF]L","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three head-to-tail tandem 6-mer repeats (636-653) followed after a 7-residue helical-turn linker by a fourth copy (661-666), anchored by invariant Q at positions 1 and 3 and a conserved hydrophobic/aromatic [HF]L C-terminal dyad.","i":[[636,641,"QQQKHL"],[642,647,"QQQQFL"],[648,653,"QRQQHL"],[661,666,"QFQRHL"]]},{"c":"[SPG]NLMP","u":5,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three widely dispersed 5-mer motifs across the disordered region sharing an invariant four-residue NLMP core preceded by a small turn-promoting [SPG] residue.","i":[[238,242,"SNLMP"],[361,365,"PNLMP"],[716,720,"GNLMP"]]}],"s":"MVLPTCPMAEFALPRHSAVMERLRRRIELCRRHHSTCEARYEAVSPERLELERQHTFALHQRCIQAKAKRAGKHRQPPAATAPAPAAPAPRLDAADGPEHGRPATHLHDTVKRNLDSATSPQNGDQQNGYGDLFPGHKKTRREAPLGVAISSNGLPPASPLGQSDKPSGADALQSSGKHSLGLDSLNKKRLADSSLHLNGGSNPSESFPLSLNKELKQEPVEDLPCMITGTVGSISQSNLMPDLNLNEQEWKELIEELNRSVPDEDMKDLFNEDFEEKKDPESSGSATQTPLAQDINIKTEFSPAAFEQEQLGSPQVRAGSAGQTFLGPSSAPVSTDSPSLGGSQTLFHTSGQPRADNPSPNLMPASAQAQNAQRALAGVVLPSQGPGGASELSSAHQLQQIAAKQKREQMLQNPQQATPAPAPGQMSTWQQTGPSHSSLDVPYPMEKPASPSSYKQDFTNSKLLMMPSVNKSSPRPGGPYLQPSHVNLLSHQPPSNLNQNSANNQGSVLDYGNTKPLSHYKADCGQGSPGSGQSKPALMAYLPQQLSHISHEQNSLFLMKPKPGNMPFRSLVPPGQEQNPSSVPVQAQATSVGTQPPAVSVASSHNSSPYLSSQQQAAVMKQHQLLLDQQKQREQQQKHLQQQQFLQRQQHLLAEQEKQQFQRHLTRPPPQYQDPTQGSFPQQVGQFTGSSAAVPGMNTLGPSNSSCPRVFPQAGNLMPMGPGHASVSSLPTNSGQQDRGVAQFPGSQNMPQSSLYGMASGITQIVAQPPPQATNGHAHIPRQTNVGQNTSVSAAYGQNSLGSSGLSQQHNKGTLNPGLTKPPVPRVSPAMGGQNSSWQHQGMPNLSGQTPGNSNVSPFTAASSFHMQQQAHLKMSSPQFSQAVPNRPMAPMSSAAAVGSLLPPVSAQQRTSAPAPAPPPTAPQQGLPGLSPAGPELGAFSQSPASQMGGRAGLHCTQAYPVRTAGQELPFAYSGQPGGSGLSSVAGHTDLIDSLLKNRTSEEWMSDLDDLLGSQ"},{"id":"SEQ_04604","a":"Q03164","g":"KMT2A","d":"Histone-lysine N-methyltransferase 2A","L":3969,"m":[{"c":"CxxC(x){9,15}C(x){2,3}Cxxx[FYV]HxxC(x){15,21}Cxx[CH]","u":"45-56","sp":"dispersed","x":"structured_like","cf":"high","why":"Four structured zinc-coordinating repeats defined by an invariant eight-ligand CxxC-Cxx(x)C-HxxC-Cxx[CH] architecture and a conserved hydrophobic [FYV] anchor immediately preceding the central histidine.","i":[[1434,1479,"CFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRC"],[1482,1530,"CHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKC"],[1569,1624,"CPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNC"],[1933,1977,"CEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRH"]]},{"c":"+[PKR]RGRP[PR][ST]","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 8-residue copies in the N-terminal disordered region sharing an invariant RGRP core flanked by N-terminal basic/proline residues and a C-terminal [PR][ST] dipeptide.","i":[[174,181,"KPRGRPRS"],[220,227,"KKRGRPPT"],[301,308,"RRRGRPPS"]]}],"s":"MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSASSSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPRSGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKIKKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRIIPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSRFSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGSRTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQYFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSNRTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESAEKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQSSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLCLSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALGRKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVCTNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSEPPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPRPSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN"},{"id":"SEQ_04615","a":"Q17RD7","g":"SYT16","d":"Synaptotagmin-16","L":645,"m":[{"c":"-LxVxφxYxAx[ST]x+L[ST]Vxψψ+[AG]oxφxxxxxoxφxxxxxxψφLL(x){5,8}Rx+ToIxR(x){1,2}PNPVΩ+ExφxFxxφ(x){8,9}ψxφxψYxxRxMxRxxMψGxxφφ","u":"102-105","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of a ~102-105 aa structured domain separated by a 53-aa Ser/Pro-rich linker, anchored by conserved positions across the full fold including LxVxφxYxAx[ST]x+L[ST]V, ψφLL, Rx+ToIxR, PNPVΩ+ExφxF, and YxxRxMxRxxMψGxxφφ.","i":[[353,454,"DLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKHRGRTNIQRGPNPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGEKLF"],[508,612,"ELLVGLSYNATTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIAL"]]}],"s":"MVLAMASQDVQNFFQPFSSWISRVYEALQQAGDMLSASLVNISKQDSKLSDKLDQDLDNIQIQETYFEDEEQDNDWSQEDANSLFLEVDHFSCCNSDLQDSAQNSSPSLSQHAKDSCSTMSQWPNWASDDRKLPHVLSSIAEEEHHLEKQRSGLQHGFDSQLPGTLETVNGKKQVNSFGDDEELSTSSDSDEEVIKQFEISVSRSQSFRSVTSEKGKQTGLEQKPKFSRSLLTHGEDGTEVSACEDLDGASQRRYSENLSYGEDDHIPAHSQSPCERGDAKHHGTSHQESSVVQSLRRQSTEGSLEMETAFNSRGFEDSYATDSSSMWSPEEQDRTNLQVPSGVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPGKKHRGRTNIQRGPNPVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYLSHLHPEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNATTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEMKETKGQQICRWHTLLES"},{"id":"SEQ_04623","a":"Q15345","g":"LRRC41","d":"Leucine-rich repeat-containing protein 41","L":812,"m":[{"c":"φxxψxφxxxxφxxxxxxxφ(x){1,3}φxxxxx","u":"26-28","sp":"tandem","x":"structured_like","cf":"high","why":"Nine 26-28 aa leucine-rich repeat units with a strictly conserved φxxψxφxxxxφ N-terminal core (often Asn at position 9) and spaced hydrophobic return positions, organized in two tandem sub-arrays (3 and 6 units, 0-4 aa gaps) separated by a 66-aa linker.","i":[[462,489,"ISTLELFTVPLSTEAALTLCHLLSSWVS"],[490,517,"LESLTLSYNGLGSNIFRLLDSLRALSGQ"],[522,549,"LRALHLSDLFSPLPILELTRAIVRALPL"],[616,643,"LQQLSLDSATFASPQDFGLVLQTLKEYN"],[646,671,"LKRLSFHDMNLADCQSEVLFLLQNLT"],[672,699,"LQEITFSFCRLFEKRPAQFLPEMVAAMK"],[704,731,"LKGLRLPGNRLGNAGLLALADVFSEDSS"],[734,761,"LCQLDISSNCIKPDGLLEFAKRLERWGR"],[764,791,"FGHLRLFQNWLDQDAVTAREAIRRLRAT"]]}],"s":"MAAPEAWRARSCWFCEVAAATTMEATSREAAPAKSSASGPNAPPALFELCGRAVSAHMGVLESGVWALPGPILQSILPLLNIYYLERIEETALKKGLSTQAIWRRLWDELMKTRPSSLESVTCWRAKFMEAFFSHVLRGTIDVSSDRRLCDQRFSPLLHSSRHVRQLTICNMLQGATELVAEPNRRVLETLASSLHTLKFRHLLFSDVAAQQSLRQLLHQLIHHGAVSQVSLYSWPVPESALFILILTMSAGFWQPGPGGPPCRLCGEASRGRAPSRDEGSLLLGSRRPRRDAAERCAAALMASRRKSEAKQMPRAAPATRVTRRSTQESLTAGGTDLKRELHPPATSHEAPGTKRSPSAPAATSSASSSTSSYKRAPASSAPQPKPLKRFKRAAGKKGARTRQGPGAESEDLYDFVFIVAGEKEDGEEMEIGEVACGALDGSDPSCLGLPALEASQRFRSISTLELFTVPLSTEAALTLCHLLSSWVSLESLTLSYNGLGSNIFRLLDSLRALSGQAGCRLRALHLSDLFSPLPILELTRAIVRALPLLRVLSIRVDHPSQRDNPGVPGNAGPPSHIIGDEEIPENCLEQLEMGFPRGAQPAPLLCSVLKASGSLQQLSLDSATFASPQDFGLVLQTLKEYNLALKRLSFHDMNLADCQSEVLFLLQNLTLQEITFSFCRLFEKRPAQFLPEMVAAMKGNSTLKGLRLPGNRLGNAGLLALADVFSEDSSSSLCQLDISSNCIKPDGLLEFAKRLERWGRGAFGHLRLFQNWLDQDAVTAREAIRRLRATCHVVSDSWDSSQAFADYVSTM"},{"id":"SEQ_04624","a":"O60732","g":"MAGEC1","d":"Melanoma-associated antigen C1","L":1142,"m":[{"c":"[ST]xx[FS]S[SY][TA][LPS]xS[LI][FLP]QS[SFH][PS]E[SRC]x[QH]S[TPA][FP]EG[FP][PAV]QSxL[QH]xP","u":34,"sp":"tandem","x":"disordered_like","cf":"high","why":"Fourteen highly conserved 34-aa repeats anchored by invariant S, Q, E, G, L, and P positions plus a conserved hydrophobic [LI][FLP] island, forming an 11-copy tandem array (1-2 aa gaps) and 3 C-terminal copies interleaved with a distinct 16-aa repeat family.","i":[[133,166,"SSFFSSALLSIFQSSPESTQSPFEGFPQSVLQIP"],[168,201,"SAASSSTLVSIFQSSPESTQSPFEGFPQSPLQIP"],[203,236,"SRSFSSTLLSIFQSSPERTQSTFEGFAQSPLQIP"],[238,271,"SPSSSSTLLSLFQSFSERTQSTFEGFAQSSLQIP"],[273,306,"SPSFSSTLVSLFQSSPERTQSTFEGFPQSPLQIP"],[308,341,"SSSSSSTLLSLFQSSPERTHSTFEGFPQSLLQIP"],[343,376,"TSSFSSTLLSIFQSSPESAQSTFEGFPQSPLQIP"],[378,411,"SPSFSSTLLSLFQSSPERTHSTFEGFPQSPLQIP"],[413,446,"TSSFSSTLLSILQSSPESAQSAFEGFPQSPLQIP"],[448,481,"SSSFSYTLLSLFQSSPERTHSTFEGFPQSPLQIP"],[484,517,"SSSSSSTLLSLFQSSPECTQSTFEGFPQSPLQIP"],[630,663,"SICSSSTPSSLPQSFPESSQSPPEGPVQSPLHSP"],[745,778,"SICSSSTSLSLPQSFPESPQSPPEGPAQSPLQRP"],[780,813,"SSFFSYTLASLLQSSHESPQSPPEGPAQSPLQSP"]]},{"c":"[QPE][SF]x[PLS][EQ][GWS]--xxx[PS][LH]xx[PSV]","u":16,"sp":"tandem","x":"disordered_like","cf":"high","why":"Seventeen non-overlapping 16-aa disordered repeats arranged in four head-to-tail tandem blocks flanking the 34-aa repeat array, defined by N-terminal QSxP, a conserved [EQ][GW]ED acidic core, and a C-terminal [PS][LH]xxP motif.","i":[[23,38,"QSCPEGEDSQSPLQIP"],[39,54,"QSSPESDDTLYPLQSP"],[55,70,"QSRSEGEDSSDPLQRP"],[84,99,"QSSPEGDDTQSPLQNS"],[100,115,"QSSPEGKDSLSPLEIS"],[116,131,"QSPPEGEDVQSPLQNP"],[518,533,"QSPPEGENTHSPLQIV"],[534,549,"PSLPEWEDSLSPHYFP"],[550,565,"QSPPQGEDSLSPHYFP"],[566,581,"QSPPQGEDSLSPHYFP"],[597,612,"QSPPQGEDSMSPLYFP"],[613,628,"QSPLQGEEFQSSLQSP"],[664,679,"QSPPEGMHSQSPLQSP"],[680,695,"ESAPEGEDSLSPLQIP"],[696,711,"QSPLEGEDSLSSLHFP"],[712,727,"QSPPEWEDSLSPLHFP"],[728,743,"QFPPQGEDFQSSLQSP"]]}],"s":"MGDKDMPTAGMPSLLQSSSESPQSCPEGEDSQSPLQIPQSSPESDDTLYPLQSPQSRSEGEDSSDPLQRPPEGKDSQSPLQIPQSSPEGDDTQSPLQNSQSSPEGKDSLSPLEISQSPPEGEDVQSPLQNPASSFFSSALLSIFQSSPESTQSPFEGFPQSVLQIPVSAASSSTLVSIFQSSPESTQSPFEGFPQSPLQIPVSRSFSSTLLSIFQSSPERTQSTFEGFAQSPLQIPVSPSSSSTLLSLFQSFSERTQSTFEGFAQSSLQIPVSPSFSSTLVSLFQSSPERTQSTFEGFPQSPLQIPVSSSSSSTLLSLFQSSPERTHSTFEGFPQSLLQIPMTSSFSSTLLSIFQSSPESAQSTFEGFPQSPLQIPGSPSFSSTLLSLFQSSPERTHSTFEGFPQSPLQIPMTSSFSSTLLSILQSSPESAQSAFEGFPQSPLQIPVSSSFSYTLLSLFQSSPERTHSTFEGFPQSPLQIPVSSSSSSSTLLSLFQSSPECTQSTFEGFPQSPLQIPQSPPEGENTHSPLQIVPSLPEWEDSLSPHYFPQSPPQGEDSLSPHYFPQSPPQGEDSLSPHYFPQSPQGEDSLSPHYFPQSPPQGEDSMSPLYFPQSPLQGEEFQSSLQSPVSICSSSTPSSLPQSFPESSQSPPEGPVQSPLHSPQSPPEGMHSQSPLQSPESAPEGEDSLSPLQIPQSPLEGEDSLSSLHFPQSPPEWEDSLSPLHFPQFPPQGEDFQSSLQSPVSICSSSTSLSLPQSFPESPQSPPEGPAQSPLQRPVSSFFSYTLASLLQSSHESPQSPPEGPAQSPLQSPVSSFPSSTSSSLSQSSPVSSFPSSTSSSLSKSSPESPLQSPVISFSSSTSLSPFSEESSSPVDEYTSSSDTLLESDSLTDSESLIESEPLFTYTLDEKVDELARFLLLKYQVKQPITKAEMLTNVISRYTGYFPVIFRKAREFIEILFGISLREVDPDDSYVFVNTLDLTSEGCLSDEQGMSQNRLLILILSIIFIKGTYASEEVIWDVLSGIGVRAGREHFAFGEPRELLTKVWVQEHYLEYREVPNSSPPRYEFLWGPRAHSEVIKRKVVEFLAMLKNTVPITFPSSYKDALKDVEERAQAIIDTTDDSTATESASSSVMSPSFSSE"},{"id":"SEQ_04639","a":"P49792","g":"RANBP2","d":"E3 SUMO-protein ligase RanBP2","L":3224,"m":[{"c":"[HY]FEP[VI]VxψP-(x){0,1}[VI]Eψx[ST]GEE[DN]ExxφΩxxR[AV]KL[FY]RΩDx-[VS]x[QE]WKERGψG[ND]ψKILx[HN]xxxxφRψψMRR-QV[LF]KψCANHxI[TS]x[DT]MxLx[PN]xx[GV][ST][DEN][RN]xφψWxAxD[FY][AS]D[GE]xxKxE[QH]LAφ+FK[TL]x-xAxxFKxxF-E[AC][QK]","u":"131-132","sp":"dispersed","x":"structured_like","cf":"high","why":"Four highly conserved ~132-aa globular domains dispersed across the C-terminal two-thirds of the protein, anchored by invariant blocks including [HY]FEP[VI]V, WKERGψG[ND]ψKIL, RψψMRR-QV[LF]KψCANH, and LAφ+FK...F-E[AC][QK] with a single 1-residue deletion near the N-terminus of the fourth copy.","i":[[1171,1302,"HFEPVVPLPDKIEVKTGEEDEEEFFCNRAKLFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGSDRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQ"],[2012,2143,"HFEPVVQMPEKVELVTGEEDEKVLYSQRVKLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSGSDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQ"],[2309,2440,"YFEPVVPLPDLVEVSSGEENEQVVFSHRAKLYRYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTERVWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAK"],[2911,3041,"HFEPIVSLPEVEVKSGEEDEEILFKERAKLYRWDRDVSQWKERGVGDIKILWHTMKNYYRILMRRDQVFKVCANHVITKTMELKPLNVSNNALVWTASDYADGEAKVEQLAVRFKTKEVADCFKKTFEECQ"]]},{"c":"Fxxxxx[KRT]K(x){0,1}G[QHS]W(x){0,1}[DH]C[SN]xC[LCS][VL][RKQ]N[EA]xo[ASV]x+C[IVA][AS]C","u":"30-32","sp":"periodic","x":"structured_like","cf":"high","why":"Eight periodically spaced (~29-33 aa linkers) C2C2 zinc-finger-like repeats anchored by an N-terminal F, conserved KG[QHS]W[DH] signature, and four invariant cysteines in a CxxC...N...CxxC register.","i":[[1344,1375,"FEFQVAKKEGSWWHCNSCSLKNASTAKKCVSC"],[1408,1438,"FALVTPKKEGHWDCSICLVRNEPTVSRCIAC"],[1472,1502,"FRSVFSTKEGQWDCSACLVQNEGSSTKCAAC"],[1536,1566,"FEDMFAKKEGQWDCSSCLVRNEANATRCVAC"],[1599,1629,"FEGMFTKKEGQWDCSVCLVRNEASATKCIAC"],[1658,1688,"FEGMFTKKEGQWDCSVCLVRNEASATKCIAC"],[1717,1747,"FEGMFTKKEGQWDCSVCLVRNEASATKCIAC"],[1775,1804,"FEGMFIRKGQWDCSVCCVQNESSSLKCVAC"]]},{"c":"[LI]IV[YW]ExxPT[AV]E[QE]KAxAxxLKLPPTFFC","u":27,"sp":"dispersed","x":"mixed","cf":"high","why":"Two strongly conserved 27-aa segments separated by a 51-aa acidic/polar linker, sharing 18 identical and 4 physicochemically conserved positions including an N-terminal [LI]IV[YW]E...PT[AV]E[QE]KA core and an identical 9-residue C-terminal LKLPPTFFC anchor.","i":[[2633,2659,"LIVYELTPTAEQKALATKLKLPPTFFC"],[2711,2737,"IIVWEKKPTVEEKAKADTLKLPPTFFC"]]},{"c":"[SGT]FxFG","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Eight dispersed 5-aa phenylalanine-glycine motifs distributed exclusively across the Pro/Ser/Thr/Gly-rich disordered linkers and regions, anchored by a small polar/glycine N-terminal [SGT] residue and invariant FxFG aromatic-glycine core.","i":[[1098,1102,"TFNFG"],[1456,1460,"SFKFG"],[1520,1524,"SFKFG"],[1583,1587,"SFKFG"],[1858,1862,"GFKFG"],[1897,1901,"GFKFG"],[1958,1962,"GFQFG"],[2839,2843,"SFGFG"]]}],"s":"MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDPKAHRFLGLLYELEENTDKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWLERAAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTKRLKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYANLMLLTLSTRDVQESRELLQSFDSALQSVKSLGGNDELSATFLEMKGHFYMHAGSLLLKMGQHSSNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLNLSRGKQDFLKEIVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVREPELEDLTRYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPHETSRLETNAPESICILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIHRKAVPGNVAKLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIGRSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAVNGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIKIIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTPSPTRYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSSNSASPHRWPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKGPVYGMNRLPPQQHIYAYPQQMHTPPVQSSSACMFSQEMYGPPALRFESPATGILSPRGDDYFNYNVQQTSTNPPLPEPGYFTKPPIAAHASRSAESKTIEFGKTNFVQPMPGEGLRPSLPTQAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVTQPPPAAYSNSESLLGLLTSDKPLQGDGYSGAKPIPGGQTIGPRNTFNFGSKNVSGISFTENMGSSQQKNSGFRRSDDMFTFHGPGKSVFGTPTLETANKNHETDGGSAHGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAKLFRFDVESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGSDRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQSILKAPGTNVAMASNQAVRIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEGSWWHCNSCSLKNASTAKKCVSCQNLNPSNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGHWDCSICLVRNEPTVSRCIACQNTKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSACLVQNEGSSTKCAACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWDCSSCLVRNEANATRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEASATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLKCVACDASKPTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFKFGHVDQENSPSFMFQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGTGFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFSSQYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRVKLFRFDAEVSQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSGSDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGPTLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKSPAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLYRYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTERVWLWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPRESPCGKIAVAVLEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSESVKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCELSKNSDIEQSSDSKVKNLFASFPTEESSINYTFKTPEKAKEKKKPEDSPSDDDVLIVYELTPTAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDDEDFETAVKKLNGKLYLDGSEKCRPLEENTADNEKECIIVWEKKPTVEEKAKADTLKLPPTFFCGVCSDTDEDNGNGEDFQSELQKVQEAQKSQTEEITSTTDSVYTGGTEVMVPSFCKSEEPDSITKSISSPSVSSETMDKPVDLSTRKEIDTDSTSQGESKIVSFGFGSSTGLSFADLASSNSGDFAFGSKDKNFQWANTGAAVFGTQSVGTQSAGKVGEDEDGSDEEVVHNEDIHFEPIVSLPEVEVKSGEEDEEILFKERAKLYRWDRDVSQWKERGVGDIKILWHTMKNYYRILMRRDQVFKVCANHVITKTMELKPLNVSNNALVWTASDYADGEAKVEQLAVRFKTKEVADCFKKTFEECQQNLMKLQKGHVSLAAELSKETNPVVFFDVCADGEPLGRITMELFSNIVPRTAENFRALCTGEKGFGFKNSIFHRVIPDFVCQGGDITKHDGTGGQSIYGDKFEDENFDVKHTGPGLLSMANQGQNTNNSQFVITLKKAEHLDFKHVVFGFVKDGMDTVKKIESFGSPKGSVCRRITITECGQI"},{"id":"SEQ_04649","a":"Q8NAP3","g":"ZBTB38","d":"Zinc finger and BTB domain-containing protein 38","L":1195,"m":[{"c":"φxCxxCxxx[FYC]xxxxxxxxHxxx(x){0,1}[HC]","u":"23-24","sp":"dispersed","x":"structured_like","cf":"high","why":"Ten 23-24 aa CxxC...Hxxx(x)[HC] zinc-binding repeats anchored by an N-terminal hydrophobic residue (mostly Y/F), invariant C3/C6/H19 positions, and a conserved aromatic/Cys residue at position 10, arranged in three short-linker clusters separated by long disordered regions.","i":[[342,364,"YNCSCCSKAFDSSTLLSAHMQLH"],[371,393,"LVCKYCNKQFTTLNRLDRHEQIC"],[460,482,"YSCVVCKRSYVTLSSLRRHANVH"],[488,510,"YPCHYCNKVFALAEYRTRHEIWH"],[516,539,"YQCIFCLETFMTYYILKNHQKSFH"],[1010,1032,"YACELCAKQFQSPSTLKMHMRCH"],[1038,1060,"YQCKTCGRCFSVQGNLQKHERIH"],[1066,1088,"FVCQYCNKAFTLNETLKIHERIH"],[1094,1116,"YHCQFCFQRFLYLSTKRNHEQRH"],[1125,1147,"YACFQCPKICKTAAALGMHQKKH"]]}],"s":"MTVMSLSRDLKDDFHSDTVLSILNEQRIRGILCDVTIIVEDTKFKAHSNVLAASSLYFKNIFWSHTICISSHVLELDDLKAEVFTEILNYIYSSTVVVKRQETVTDLAAAGKKLGISFLEDLTDRNFSNSPGPYVFCITEKGVVKEEKNEKRHEEPAITNGPRITNAFSIIETENSNNMFSPLDLRASFKKVSDSMRTASLCLERTDVCHEAEPVRTLAEHSYAVSSVAEAYRSQPVREHDGSSPGNTGKENCEALAAKPKTCRKPKTFSIPQDSDSATENIPPPPVSNLEVNQERSPQPAAVLTRSKSPNNEGDVHFSREDENQSSDVPGPPAAEVPPLVYNCSCCSKAFDSSTLLSAHMQLHKPTQEPLVCKYCNKQFTTLNRLDRHEQICMRSSHMPIPGGNQRFLENYPTIGQNGGSFTGPEPLLSENRIGEFSSTGSTLPDTDHMVKFVNGQMLYSCVVCKRSYVTLSSLRRHANVHSWRRTYPCHYCNKVFALAEYRTRHEIWHTGERRYQCIFCLETFMTYYILKNHQKSFHAIDHRLSISKKTANGGLKPSVYPYKLYRLLPMKCKRAPYKSYRNSSYENARENSQMNESAPGTYVVQNPHSSELPTLNFQDTVNTLTNSPAIPLETSACQDIPTSANVQNAEGTKWGEEALKMDLDNNFYSTEVSVSSTENAVSSDLRAGDVPVLSLSNSSENAASVISYSGSAPSVIVHSSQFSSVIMHSNAIAAMTSSNHRAFSDPAVSQSLKDDSKPEPDKVGRFASRPKSIKEKKKTTSHTRGEIPEESNYVADPGGSLSKTTNIAEETSKIETYIAKPALPGTSTNSNVAPLCQITVKIGNEAIVKRHILGSKLFYKRGRRPKYQMQEEPLPQGNDPEPSGDSPLGLCQSECMEMSEVFDDASDQDSTDKPWRPYYNYKPKKKSRQLKKMRKVNWRKEHGNRSPSHKCKYPAELDCAVGKAPQDKPFEEEETKEMPKLQCELCDGDKAVGAGNQGRPHRHLTSRPYACELCAKQFQSPSTLKMHMRCHTGEKPYQCKTCGRCFSVQGNLQKHERIHLGLKEFVCQYCNKAFTLNETLKIHERIHTGEKRYHCQFCFQRFLYLSTKRNHEQRHIREHNGKGYACFQCPKICKTAAALGMHQKKHLFKSPSQQEKIGDVCHENSNPLENQHFIGSEDNDQKDNIQTGVENVVL"},{"id":"SEQ_04658","a":"Q9P127","g":"LUZP4","d":"Leucine zipper protein 4","L":313,"m":[{"c":"[EKG]R[SH]H[GP][HQ][SY]","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Eight 7-aa polar/histidine-rich repeats with invariant R2 and H4 anchors and tightly constrained flanking positions ([EKG], [SH], [GP], [HQ], [SY]), occurring as a 7-copy head-to-tail tandem array (flanked by four more divergent xRSxx[HQ]x 7-mers) plus one C-terminal copy separated by the TQxDLIA array.","i":[[181,187,"KRHHPQY"],[188,194,"ERSHGQY"],[195,201,"KRSHGQS"],[202,208,"ERSHGHS"],[209,215,"ERSHGHS"],[216,222,"ERSHGHS"],[223,229,"ERSHGHS"],[292,298,"GRSHGQS"]]},{"c":"T[QE][RKS]DL[IV][AVN]","u":7,"sp":"tandem","x":"mixed","cf":"high","why":"Seven head-to-tail tandem 7-aa repeats anchored by invariant T1, D4, and L5 residues alongside conserved [QE]2, [RKS]3, and aliphatic [IV]6/[AVN]7 positions.","i":[[241,247,"TQSDLIA"],[248,254,"TQRDLIA"],[255,261,"TQKDLIA"],[262,268,"TQRDLIA"],[269,275,"TQRDLIV"],[276,282,"TQRDLVA"],[283,289,"TERDLIN"]]},{"c":"[NS][QP][GHD][QK][SP]E[GE]","u":7,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Four contiguous 7-aa tandem repeats in the N-terminal disordered region anchored by invariant E6 and conserved Q/S/G/N positions (three closely matched [NS]Q[GH]Q[SP]E[GE] units surrounding one divergent in-register NPDKSEE unit).","i":[[128,134,"NQGQSEG"],[135,141,"NQHQSEG"],[142,148,"NPDKSEE"],[149,155,"SQGQPEE"]]}],"s":"MASFRKLTLSEKVPPNHPSRKKVNFLDMSLDDIIIYKELEGTNAEEEKNKRQNHSKKESPSRQQSKAHRHRHRRGYSRCRSNSEEGNHDKKPSQKPSGFKSGQHPLNGQPLIEQEKCSDNYEAQAEKNQGQSEGNQHQSEGNPDKSEESQGQPEENHHSERSRNHLERSLSQSDRSQGQLKRHHPQYERSHGQYKRSHGQSERSHGHSERSHGHSERSHGHSERSHGHSKRSRSQGDLVDTQSDLIATQRDLIATQKDLIATQRDLIATQRDLIVTQRDLVATERDLINQSGRSHGQSERHQRYSTGKNTITT"},{"id":"SEQ_04659","a":"P49711","g":"CTCF","d":"Transcriptional repressor CTCF","L":727,"m":[{"c":"xxCxxCxxxxxxxxx[LM]xxHxxx(x){0,1}[HC]","u":"23-24","sp":"periodic","x":"structured_like","cf":"high","why":"Eleven 23-24 aa CxxC...Hxxx(x)[HC] repeats with invariant C3, C6, and H19 anchors, a strictly conserved aliphatic [LM]16 core position, and regular 5-8 aa (predominantly TGE[KR]P-like) linkers.","i":[[266,288,"FQCELCSYTCPRRSNLDRHMKSH"],[294,316,"HKCHLCGRAFRTVTLLRNHLNTH"],[322,345,"HKCPDCDMAFVTSGELVRHRRYKH"],[351,373,"FKCSMCDYASVEVSKLKRHIRSH"],[379,401,"FQCSLCSYASRDTYKLKRHMRTH"],[407,430,"YECYICHARFTQSGTMKMHILQKH"],[437,460,"FHCPHCDTVIARKSDLGVHLRKQH"],[467,489,"KKCRYCDAVFHERYALIQHQKSH"],[495,517,"FKCDQCDYACRQERHMIMHKRTH"],[523,546,"YACSHCDKTFRQKQLLDMHFKRYH"],[555,577,"FVCSKCGKTFTRRNTMARHADNC"]]}],"s":"MEGDAVEAIVEESETFIKGKERKTYQRRREGGQEEDACHLPQNQTDGGEVVQDVNSSVQMVMMEQLDPTLLQMKTEVMEGTVAPEAEAAVDDTQIITLQVVNMEEQPINIGELQLVQVPVPVTVPVATTSVEELQGAYENEVSKEGLAESEPMICHTLPLPEGFQVVKVGANGEVETLEQGELPPQEDPSWQKDPDYQPPAKKTKKTKKSKLRYTEEGKDVDVSVYDFEEEQQEGLLSEVNAEKVVGNMKPPKPTKIKKKGVKKTFQCELCSYTCPRRSNLDRHMKSHTDERPHKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCPDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQCDYACRQERHMIMHKRTHTGEKPYACSHCDKTFRQKQLLDMHFKRYHDPNFVPAAFVCSKCGKTFTRRNTMARHADNCAGPDGVEGENGGETKKSKRGRKRKMRSKKEDSSDSENAEPDLDDNEDEEEPAVEIEPEPEPQPVTPAPPPAKKRRGRPPGRTNQPKQNQPTAIIQVEDQNTGAIENIIVEVKKEPDAEPAEGEEEEAQPAATDAPNGDLTPEMILSMMDR"},{"id":"SEQ_04674","a":"Q96PE1","g":"ADGRA2","d":"Adhesion G protein-coupled receptor A2","L":1338,"m":[{"c":"xxLxψ[SR][NG]Nxφ[STG]xψxx[GE]xFx[GE]L[PGS]xL","u":24,"sp":"tandem","x":"structured_like","cf":"high","why":"Four head-to-tail 24-residue structured repeats in the N-terminal region anchored by strictly invariant L, N, F, L, and L positions alongside conserved aliphatic/hydrophobic core residues (ψ/φ) and [GE] turn positions.","i":[[87,110,"VTLLLSNNKITGLRNGSFLGLSLL"],[111,134,"EKLDLRNNIISTVQPGAFLGLGEL"],[135,158,"KRLDLSNNRIGCLTSETFQGLPRL"],[159,182,"LRLNISGNIFSSLQPGVFDELPAL"]]}],"s":"MGAGGRRMRGAPARLLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGPARRRVVCSGGDLPEPPEPGLLPNGTVTLLLSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDCTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAERVANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSRIVGALERIGGAALSPHAQHISVNARNVALEAYLIKPHSYVGLTCTAFQRREGGVPGTRPGSPGQNPPPEPEPPADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSLPAALAPPVPPDCTLQLLVFRNGRLFHSHSNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAEPVAAWWSQEGPGEAGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSAFPREVGGAGAGLHPVVYPCTALLLLCLFATIITYILNHSSIRVSRKGWHMLLNLCFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLSTLLWMGVKARVLHKELTWRAPPPQEGDPALPTPSPMLRFYLIAGGIPLIICGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQNPKAGNSRASLEAGEELRGSTRLRGSGPLLSDSGSLLATGSARVGTPGPPEDGDSLYSPGVQLGALVTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACCPPASPAAPHAPPRALPAAAEDGSPVFGEGPPSLKSSPSGSSGHPLALGPCKLTNLQLAQSQVCEAGAAAGGEGEPEPAGTRGNLAHRHPNNVHHGRRAHKSRAKGHRAGEACGKNRLKALRGGAAGALELLSSESGSLHNSPTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSDTSAAPLSEAGRAGQRRSASRDSLKGGGALEKESHRRSYPLNAASLNGAPKGGKYDDVTLMGAEVASGGCMKTGLWKSETTV"},{"id":"SEQ_04681","a":"Q96PM9","g":"ZNF385A","d":"Zinc finger protein 385A","L":386,"m":[{"c":"φxCx[IL]Cx[IV]x[FV]NSx[SV]Q[AL][EK][AQ]Hx[KS][GS]x+H","u":25,"sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed 25-aa copies anchored by invariant C-x2-C and H-x4-H metal-coordinating pairs, an invariant internal NSxxQ core, conserved hydrophobic framework positions, and a basic residue preceding the terminal histidine.","i":[[74,98,"ISCNICQIRFNSQSQAEAHYKGNRH"],[201,225,"LYCALCKVAVNSLSQLEAHNKGTKH"],[261,285,"FHCEICNVKVNSEVQLKQHISSRRH"]]}],"s":"MILGSLSRAGPLPLLRQPPIMQPPLDLKQILPFPLEPAPTLGLFSNYSTMDPVQKAVLSHTFGGPLLKTKRPVISCNICQIRFNSQSQAEAHYKGNRHARRVKGIEAAKTRGREPGVREPGDPAPPGSTPTNGDGVAPRPVSMENGLGPAPGSPEKQPGSPSPPSIPETGQGVTKGEGGTPAPASLPGGSKEEEEKAKRLLYCALCKVAVNSLSQLEAHNKGTKHKTILEARSGLGPIKAYPRLGPPTPGEPEAPAQDRTFHCEICNVKVNSEVQLKQHISSRRHRDGVAGKPNPLLSRHKKSRGAGELAGTLTFSKELPKSLAGGLLPSPLAVAAVMAAAAGSPLSLRPAPAAPLLQGPPITHPLLHPAPGPIRTAHGPILFSPY"},{"id":"SEQ_04684","a":"Q7Z2D5","g":"PLPPR4","d":"Phospholipid phosphatase-related protein type 4","L":763,"m":[{"c":"[IL][IV]xIP[ES]","u":6,"sp":"periodic","x":"disordered_like","cf":"medium","why":"Three 6-aa hydrophobic-proline islands within the polar/disordered C-terminal tail sharing a bulky aliphatic dipeptide ([IL][IV]) followed by x-I-P-[ES], separated by regular ~95-aa linkers.","i":[[533,538,"LVHIPE"],[633,638,"IIQIPS"],[734,739,"IILIPE"]]}],"s":"MQRAGSSGGRGECDISGAGRLGLEEAARLSCAVHTSPGGGRRPGQAAGMSAKERPKGKVIKDSVTLLPCFYFVELPILASSVVSLYFLELTDVFKPVHSGFSCYDRSLSMPYIEPTQEAIPFLMLLSLAFAGPAITIMVGEGILYCCLSKRRNGVGLEPNINAGGCNFNSFLRRAVRFVGVHVFGLCSTALITDIIQLSTGYQAPYFLTVCKPNYTSLNVSCKENSYIVEDICSGSDLTVINSGRKSFPSQHATLAAFAAVYVSMYFNSTLTDSSKLLKPLLVFTFIICGIICGLTRITQYKNHPVDVYCGFLIGGGIALYLGLYAVGNFLPSDESMFQHRDALRSLTDLNQDPNRLLSAKNGSSSDGIAHTEGILNRNHRDASSLTNLKRANADVEIITPRSPMGKENMVTFSNTLPRANTPSVEDPVRRNASIHASMDSARSKQLLTQWKNKNESRKLSLQVIEPEPGQSPPRSIEMRSSSEPSRVGVNGDHHGPGNQYLKIQPGAVPGCNNSMPGGPRVSIQSRPGSSQLVHIPEETQENISTSPKSSSARAKWLKAAEKTVACNRSNSQPRIMQVIAMSKQQGVLQSSPKNTEGSTVSCTGSIRYKTLTDHEPSGIVRVEAHPENNRPIIQIPSTEGEGSGSWKWKAPEKGSLRQTYELNDLNRDSESCESLKDSFGSGDRKRSNIDSNEHHHHGITTIRVTPVEGSEIGSETLSISSSRDSTLRRKGNIILIPERSNSPENTRNIFYKGTSPTRAYKD"},{"id":"SEQ_04706","a":"P30622","g":"CLIP1","d":"CAP-Gly domain-containing linker protein 1","L":1438,"m":[{"c":"-φ+ψG-RVφVxGoKxGφψxFLGETxFAxGxWxGψxLDEPψGKNDG[SA]VAGxRYFQCxPxxGψFxxxxKψT+","u":70,"sp":"dispersed","x":"structured_like","cf":"high","why":"Strongly conserved 70-residue globular domain duplication in the N-terminal region separated by an 84-aa S/T/P-rich linker, anchored by invariant G, R, V, K, FLGET, F, A, W, LDEP, GKNDG, VAG, RYFQC, P, and F positions.","i":[[57,126,"DFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIFTRPSKLTR"],[211,280,"ELKIGDRVLVGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTK"]]},{"c":"LK[PAT][PSG][GST]","u":5,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Four tandem LK-anchored proline/small-polar 5-mer repeats (with 0-2 aa spacers forming a paired LKPSG-LKAPTKI / LKPGSTA-LKTPTAV duplication) in the disordered N-terminal tail.","i":[[4,8,"LKPSG"],[9,13,"LKAPT"],[16,20,"LKPGS"],[23,27,"LKTPT"]]}],"s":"MSMLKPSGLKAPTKILKPGSTALKTPTAVVAPVEKTISSEKASSTPSSETQEEFVDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAKEPSATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEQKSQISEDPENTQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRGEERPYCEICEMFGHWATNCNDDETF"},{"id":"SEQ_04720","a":"Q9NYG8","g":"KCNK4","d":"Potassium channel subfamily K member 4","L":393,"m":[{"c":"WxxxxAφΩFxxxxψTTψGΩG[ND]φφφxxD","u":27,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two-copy internal duplication of a 27-residue pore-loop segment in exact gapless register anchored by conserved W, A, F, TT, GxG, and C-terminal D positions alongside conserved aromatic and aliphatic hydrophobics.","i":[[88,114,"WDLGSAFFFSGTIITTIGYGNVALRTD"],[197,223,"WSKLEAIYFVIVTLTTVGFGDYVAGAD"]]}],"s":"MRSTTLLALLALVLLYLVSGALVFRALEQPHEQQAQRELGEVREKFLRAHPCVSDQELGLLIKEVADALGGGADPETNSTSNSSHSAWDLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIPLFGILLAGVGDRLGSSLRHGIGHIEAIFLKWHVPPELVRVLSAMLFLLIGCLLFVLTPTFVFCYMEDWSKLEAIYFVIVTLTTVGFGDYVAGADPRQDSPAYQPLVWFWILLGLAYFASVLTTIGNWLRVVSRRTRAEMGGLTAQAASWTGTVTARVTQRAGPAAPPPEKEQPLLPPPPCPAQPLGRPRSPSPPEKAQPPSPPTASALDYPSENLAFIDESSDTQSERGCPLPRAPRGRRRPNPPRKPVRPRGPGRPRDKGVPV"},{"id":"SEQ_04747","a":"Q8TF74","g":"WIPF2","d":"WAS/WASL-interacting protein family member 2","L":440,"m":[{"c":"[PAK]PPPP[PV]xR","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Six dispersed copies in the proline/serine-rich disordered region share a core PPPP[PV] tract strictly anchored at the C-terminus by a conserved basic arginine (+2 from the proline core) and constrained N-terminal [PAK] residues.","i":[[177,184,"PPPPPPGR"],[249,256,"APPPPPYR"],[326,333,"PPPPPVIR"],[340,347,"PPPPPPYR"],[358,365,"KPPPPPSR"],[372,379,"PPPPPPLR"]]}],"s":"MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQGGVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPPPPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTNESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAAPPPPPPVIRNGARDAPPPPPPYRMHGSEPPSRGKPPPPPSRTPAGPPPPPPPPLRNGHRDSITTVRSFLDDFESKYSFHPVEDFPAPEEYKHFQRIYPSKTNRAARGAPPLPPILR"},{"id":"SEQ_04752","a":"Q8IUX7","g":"AEBP1","d":"Adipocyte enhancer-binding protein 1","L":1158,"m":[{"c":"[GP]KEKPPKATKK","u":11,"sp":"tandem","x":"disordered_like","cf":"high","why":"Four head-to-tail tandem 11-mer repeats in the N-terminal disordered region with 10 of 11 positions strictly invariant (KEKPPKATKK) and position 1 constrained to [GP].","i":[[120,130,"GKEKPPKATKK"],[131,141,"PKEKPPKATKK"],[142,152,"PKEKPPKATKK"],[153,163,"PKEKPPKATKK"]]},{"c":"T[EKQ][VL][EV][PT]EF[EG]","u":8,"sp":"tandem","x":"disordered_like","cf":"high","why":"Five head-to-tail tandem 8-mer repeats in the C-terminal acidic disordered tail anchored by invariant T1, E6, and aromatic F7 positions, aliphatic [VL]3, and conserved [PT]5 and [EG]8 positions.","i":[[1087,1094,"TEVVTEFG"],[1095,1102,"TEVEPEFG"],[1103,1110,"TKVEPEFE"],[1111,1118,"TQLEPEFE"],[1119,1126,"TQLEPEFE"]]}],"s":"MAAVRGAPLLSCLLALLALCPGGRPQTVLTDDEIEEFLEGFLSELEPEPREDDVEAPPPPEPTPRVRKAQAGGKPGKRPGTAAEVPPEKTKDKGKKGKKDKGPKVPKESLEGSPRPPKKGKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPPSGKRPPILAPSETLEWPLPPPPSPGPEELPQEGGAPLSNNWQNPGEETHVEAREHQPEPEEETEQPTLDYNDQIEREDYEDFEYIRRQKQPRPPPSRRRRPERVWPEPPEEKAPAPAPEERIEPPVKPLLPPLPPDYGDGYVIPNYDDMDYYFGPPPPQKPDAERQTDEEKEELKKPKKEDSSPKEETDKWAVEKGKDHKEPRKGEELEEEWTPTEKVKCPPIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQTGATEDDYYDGAWCAEDDARTQWIEVDTRRTTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCSVAPVYSYYAQNEVVATDDLDFRHHSYKDMRQLMKVVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGEHELGEPEFRYTAGIHGNEVLGRELLLLLMQYLCREYRDGNPRVRSLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIFEDFPDLNSVLWGAEERKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIIAWMEKNPFVLGANLNGGERLVSYPYDMARTPTQEQLLAAAMAAARGEDEDEVSEAQETPDHAIFRWLAISFASAHLTLTEPYRGGCQAQDYTGGMGIVNGAKWNPRTGTINDFSYLHTNCLELSFYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTPSAKTCNVDYDIGATQCNFILARSNWKRIREIMAMNGNRPIPHIDPSRPMTPQQRRLQQRRLQHRLRLRAQMRLRRLNATTTLGPHTVPPTLPPAPATTLSTTIEPWGLIPPTTAGWEESETETYTEVVTEFGTEVEPEFGTKVEPEFETQLEPEFETQLEPEFEEEEEEEKEEEIATGQAFPFTTVETYTVNFGDF"},{"id":"SEQ_04755","a":"Q9UKN7","g":"MYO15A","d":"Unconventional myosin-XV","L":3530,"m":[{"c":"φψxφ[QR][RS]xφ[RH][GA]Ωφx+[RQ]RΩxxψRxx","u":23,"sp":"tandem","x":"structured_like","cf":"high","why":"Three head-to-tail 23-aa amphipathic basic helical repeats anchored by conserved hydrophobic/aliphatic positions (1, 2, 4, 8, 12, 20), paired aromatics (positions 11 and 17), [GA] at position 10, and invariant basic R anchors (positions 14, 16, 21).","i":[[1906,1928,"ALTLQRCLRGFFIKRRFRSLRHK"],[1929,1951,"IILLQSRARGYLARQRYQQMRRS"],[1952,1974,"LVKFRSLVHAYVSRRRYLKLRAE"]]},{"c":"A[VT]xψFxφψψRFMGD[PA]xL[HK]Gxx-xxφxxxψψ[QK]xxxxxxxψRDExφxQψφxQψ(x){9,11}[EQ]RGW[LR]LLφφxx[SA]xx[AS]xSxxφxxxLx+FψoDφ[GS]Ro(x){1,4}FQ[AG]ψ","u":"99-104","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of a ~100-aa structured domain separated by ~890 residues, sharing invariant multi-residue signature blocks including AxxψFxφψψRFMGDxxLxG, ψRDE, [EQ]RGW[LR]LLφφ, Lx+FψoDφ[GS]Ro, and C-terminal FQ[AG]ψ across two short variable loops.","i":[[2085,2183,"AVSIFKLILRFMGDPHLHGARENIFGNYIVQKGLAVPELRDEILAQLANQVWHNHNAHNAERGWLLLAACLSGFAPSPCFNKYLLKFVSDYGRNGFQAV"],[3071,3174,"ATDMFLAVMRFMGDAPLKGQSDLDVLCNLLKLCGDHEVMRDECYCQVVKQITDNTSSKQDSCQRGWRLLYIVTAYHSCSEVLHPHLTRFLQDVSRTPGLPFQGI"]]},{"c":"PPKD[VI][TL]","u":6,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three contiguous head-to-tail hexapeptide repeats within the N-terminal proline-rich disordered region sharing an invariant PPKD core followed by conserved aliphatic [VI][TL] positions.","i":[[1034,1039,"PPKDVT"],[1040,1045,"PPKDIT"],[1046,1051,"PPKDVL"]]}],"s":"MAKEEDEEKKAKKGKKGKKAPEPEKPKRSLKGTSRLFMGFRDRTPKISKKGQFRSASAFFWGLHTGPQKTKRKRKARTVLKSTSKLMTQMRMGKKKRAMKGKKPSFMVIRFPGRRGYGRLRPRARSLSKASTAINWLTKKFLLKKAEESGSEQATVDAWLQRSSSRMGSRKLPFPSGAEILRPGGRLRRFPRSRSIYASGEPLGFLPFEDEAPFHHSGSRKSLYGLEGFQDLGEYYDYHRDGDDYYDRQSLHRYEEQEPYLAGLGPYSPAWPPYGDHYYGYPPEDPYDYYHPDYYGGPFDPGYTYGYGYDDYEPPYAPPSGYSSPYSYHDGYEGEAHPYGYYLDPYAPYDAPYPPYDLPYHTPYDVPYFDPYGVHYTVPYAEGVYGGGDEAIYPPEVPYFYPEESASAFVYPWVPPPIPSPHNPYAHAMDDIAELEEPEDAGVERQGTSFRLPSAAFFEQQGMDKPARSKLSLIRKFRLFPRPQVKLFGKEKLEVPLPPSLDIPLPLGDADEEEDEEELPPVSAVPYGHPFWGFLTPRQRNLQRALSAFGAHRGLGFGPEFGRPVPRPATSLARFLKKTLSEKKPIARLRGSQKARAGGPAVREAAYKRFGYKLAGMDPEKPGTPIVLRRAQPRARSSNDARRPPAPQPAPRTLSHWSALLSPPVPPRPPSSGPPPAPPLSPALSGLPRPASPYGSLRRHPPPWAAPAHVPPAPQASWWAFVEPPAVSPEVPPDLLAFPGPRPSFRGSRRRGAAFGFPGASPRASRRRAWSPLASPQPSLRSSPGLGYCSPLAPPSPQLSLRTGPFQPPFLPPARRPRSLQESPAPRRAAGRLGPPGSPLPGSPRPPSPPLGLCHSPRRSSLNLPSRLPHTWRRLSEPPTRAVKPQVRLPFHRPPRAGAWRAPLEHRESPREPEDSETPWTVPPLAPSWDVDMPPTQRPPSPWPGGAGSRRGFSRPPPVPENPFLQLLGPVPSPTLQPEDPAADMTRVFLGRHHEPGPGQLTKSAGPTPEKPEEEATLGDPQLPAETKPPTPAPPKDVTPPKDITPPKDVLPEQKTLRPSLSYPLAACDQTRATWPPWHRWGTLPQAAAPLAPIRAPEPLPKGGERRQAAPGRFAVVMPRVQKLSSFQRVGPATLKPQVQPIQDPKPRACSLRWSCLWLRADAYGPWPRVHTHPQSCHLGPGAACLSLRGSWEEVGPPSWRNKMHSIRNLPSMRFREQHGEDGVEDMTQLEDLQETTVLSNLKIRFERNLIYTYIGSILVSVNPYQMFGIYGPEQVQQYNGRALGENPPHLFAVANLAFAKMLDAKQNQCIIISGESGSGKTEATKLILRYLAAMNQKREVMQQIKILEATPLLESFGNAKTVRNDNSSRFGKFVEIFLEGGVISGAITSQYLLEKSRIVFQAKNERNYHIFYELLAGLPAQLRQAFSLQEAETYYYLNQGGNCEIAGKSDADDFRRLLAAMEVLGFSSEDQDSIFRILASILHLGNVYFEKYETDAQEVASVVSAREIQAVAELLQISPEGLQKAITFKVTETMREKIFTPLTVESAVDARDAIAKVLYALLFSWLITRVNALVSPRQDTLSIAILDIYGFEDLSFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQIDWQEITFADNQPCINLISLKPYGILRILDDQCCFPQATDHTFLQKCHYHHGANPLYSKPKMPLPEFTIKHYAGKVTYQVHKFLDKNHDQVRQDVLDLFVRSRTRVVAHLFSSHAPQAAPQRLGKSSSVTRLYKAHTVAAKFQQSLLDLVEKMERCNPLFMRCLKPNHKKEPGLFEPDVVMAQLRYSGVLETVRIRKEGFPVRLPFQGFIDRYCCLVALKHDLPANGDMCVSVLSRLCKVMPNMYRVGVSKLFLKEHLYQLLESMREHVLNLAALTLQRCLRGFFIKRRFRSLRHKIILLQSRARGYLARQRYQQMRRSLVKFRSLVHAYVSRRRYLKLRAEWRCQVEGALLWEQEELSKREVVAVGHLEVPAELAGLLQAVAGLGLAQVPQVAPVRTPRLQAEPRVTLPLDINNYPMAKFVQCHFKEPAFGMLTVPLRTPLTQLPAEHHAEAVSIFKLILRFMGDPHLHGARENIFGNYIVQKGLAVPELRDEILAQLANQVWHNHNAHNAERGWLLLAACLSGFAPSPCFNKYLLKFVSDYGRNGFQAVCQHRLMQAMGRAQQQGSGAARTLPPTQLEWTATYEKASMALDVGCFNGDQFSCPVHSWSTGEEVAGDILRHRGLADGWRGWTVAMKNGVQWAELAGHDYVLDLVSDLELLRDFPRQKSYFIVGTEGPAASRGGPKVVFGNSWDSDEDMSTRPQPQEHMPKVLDSDGYSSHNQDGTNGETEAQRGTATHQESDSLGEPAVPHKGLDCYLDSLFDPVLSYGDADLEKPTAIAYRMKGGGQPGGGSSSGTEDTPRRPPEPKPIPGLDASTLALQQAFIHKQAVLLAREMTLQATALQQQPLSAALRSLPAEKPPAPEAQPTSVGTGPPAKPVLLRATPKPLAPAPLAKAPRLPIKPVAAPVLAQDQASPETTSPSPELVRYSTLNSEHFPQPTQQIKNIVRQYQQPFRGGRPEALRKDGGKVFMKRPDPHEEALMILKGQMTHLAAAPGTQVSREAVALVKPVTSAPRPSMAPTSALPSRSLEPPEELTQTRLHRLINPNFYGYQDAPWKIFLRKEVFYPKDSYSHPVQLDLLFRQILHDTLSEACLRISEDERLRMKALFAQNQLDTQKPLVTESVKRAVVSTARDTWEVYFSRIFPATGSVGTGVQLLAVSHVGIKLLRMVKGGQEAGGQLRVLRAYSFADILFVTMPSQNMLEFNLASEKVILFSARAHQVKTLVDDFILELKKDSDYVVAVRNFLPEDPALLAFHKGDIIHLQPLEPPRVGYSAGCVVRRKVVYLEELRRRGPDFGWRFGTIHGRVGRFPSELVQPAAAPDFLQLPTEPGRGRAAAVAAAVASAAAAQEVGRRREGPPVRARSADHGEDALALPPYTMLEFAQKYFRDPQRRPQDGLRLKSKEPRESRTLEDMLCFTKTPLQESLIELSDSSLSKMATDMFLAVMRFMGDAPLKGQSDLDVLCNLLKLCGDHEVMRDECYCQVVKQITDNTSSKQDSCQRGWRLLYIVTAYHSCSEVLHPHLTRFLQDVSRTPGLPFQGIAKACEQNLQKTLRFGGRLELPSSIELRAMLAGRSSKRQLFLLPGGLERHLKIKTCTVALDVVEEICAEMALTRPEAFNEYVIFVVTNRGQHVCPLSRRAYILDVASEMEQVDGGYMLWFRRVLWDQPLKFENELYVTMHYNQVLPDYLKGLFSSVPASRPSEQLLQQVSKLASLQHRAKDHFYLPSVREVQEYIPAQLYRTTAGSTWLNLVSQHRQQTQALSPHQARAQFLGLLSALPMFGSSFFFIQSCSNIAVPAPCILAINHNGLNFLSTETHELMVKFPLKEIQSTRTQRPTANSSYPYVEIALGDVAAQRTLQLQLEQGLELCRVVAVHVENLLSAHEKRLTLPPSEITLL"},{"id":"SEQ_04765","a":"Q68DC2","g":"ANKS6","d":"Ankyrin repeat and SAM domain-containing protein 6","L":871,"m":[{"c":"xxxx[GD]x[TS][APV]LxxAxxxGxxxψ[VA]xxLψxx[GH]Ax[VP][NDT]x","u":33,"sp":"tandem","x":"structured_like","cf":"high","why":"Seven 33-aa structured repeat units defined by invariant L9, A12, G16, L24, and A29 anchors alongside conserved [GD]5, [TS]7, [APV]8, and aliphatic core positions (ψ20-[VA]21, L24-ψ25), arranged in three head-to-tail tandem stacks separated by a 14-aa loop and a 68-aa divergent central segment.","i":[[74,106,"SDEAGNTALQFAAAGGHEPLVRFLLRRGASVNS"],[107,139,"RNHYGWSALMQAARFGHVSVAHLLLDHGADVNA"],[140,172,"QNRLGASVLTVASRGGHLGVVKLLLEAGAFVDH"],[187,219,"DEPLDITALMAAIQHGHEAVVRLLMEWGADPNH"],[221,253,"ARTVGWSPLMLAALTGRLGVAQQLVEKGANPDH"],[322,354,"VNGDGATPLMLAAVTGQLALVQLLVERHADVDK"],[356,388,"DSVHGWTALMQATYHGNKEIVKYLLNQGADVTL"]]}],"s":"MGEGGLPPAFQLLLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVNKDKGRPSHQPPLPHSKVRQPWSIPVLPDDKGGLKSWWNRMSNRFRKLKLMQTLPRGLSSNQPLPFSDEPEPALDSTMRAAPQDKTSRSALPDAAPVTKDNGPGSTRGEKEDTLLTTMLRNGAPLTRLPSDKLKAVIPPFLPPSSFELWSSDRSRTRHNGKADPMKTALPQRASRGHPVGGGGTDTTPVRPVKFPSLPRSPASSANSGNFNHSPHSSGGSSGVGVSRHGGELLNRSGGSIDNVLSQIAAQRKKAAGLLEQKPSHRSSPVGPAPGSSPSELPASPAGGSAPVGKKLETSKRPPSGTSTTSKSTSPTLTPSPSPKGHTAESSVSSSSSHRQSKSSGGSSSGTITDEDELTGILKKLSLEKYQPIFEEQEVDMEAFLTLTDGDLKELGIKTDGSRQQILAAISELNAGKGRERQILQETIHNFHSSFESSASNTRAPGNSPCA"},{"id":"SEQ_04766","a":"P61129","g":"ZC3H6","d":"Zinc finger CCCH domain-containing protein 6","L":1189,"m":[{"c":"[IP]CK[FY][FY]xxG(x){1,2}Cx[KQ]G-[NQ]C[IK][FY]xH[DN]","u":"21-22","sp":"dispersed","x":"structured_like","cf":"high","why":"Three conserved CCCH-type zinc-coordinating repeats (21-22 aa) separated by 8-aa and 2-aa linkers, anchored by invariant C-x7/8-C-x5-C-x3-H cysteine/histidine spacing, aromatic [FY][FY] dyad, and conserved glycines.","i":[[277,297,"ICKYFLEGRCIKGDQCKFDHD"],[306,326,"ICKFYLQGYCTKGENCIYMHN"],[329,350,"PCKFYHSGAKCYQGDNCKFSHD"]]},{"c":"DPR[LKQ]x+","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five non-overlapping copies of a short linear motif dispersed across the C-terminal disordered region (residues 742-1151), anchored by an invariant N-terminal DPR triad, [LKQ] at position 4, and a C-terminal basic residue.","i":[[742,747,"DPRLAK"],[784,789,"DPRKLR"],[962,967,"DPRLQK"],[970,975,"DPRLHR"],[1147,1152,"DPRQAR"]]}],"s":"MTDSEHAGHDREDGELEDGEIDDAGFEEIQEKEAKENEKQKSEKAYRKSRKKHKKEREKKKSKRRKREKHKHNSPSSDDSSDYSLDSDVEHTESSHKKRTGFYRDYDIPFTQRGHISGSYITSKKGQHNKKFKSKEYDEYSTYSDDNFGNYSDDNFGNYGQETEEDFANQLKQYRQAKETSNIALGSSFSKESGKKQRMKGVQQGIEQRVKSFNVGRGRGLPKKIKRKERGGRTNKGPNVFSVSDDFQEYNKPGKKWKVMTQEFINQHTVEHKGKQICKYFLEGRCIKGDQCKFDHDAELEKRKEICKFYLQGYCTKGENCIYMHNEFPCKFYHSGAKCYQGDNCKFSHDDLTKETKKLLDKVLNTDEELINEDERELEELRKRGITPLPKPPPGVGLLPTPPEHFPFSDPEDDFQTDFSDDFRKIPSLFEIVVKPTVDLAHKIGRKPPAFYTSASPPGPQFQGSSPHPQHIYSSGSSPGPGPNMSQGHSSPVMHPGSPGHHPCAGPPGLPVPQSPPLPPGPPEIVGPQNQAGVLVQPDTSLTPPSMGGAYHSPGFPGHVMKVPRENHCSPGSSYQQSPGEMQLNTNYESLQNPAEFYDNYYAQHSIHNFQPPNNSGDGMWHGEFAQQQPPVVQDSPNHGSGSDGSSTRTGHGPLPVPGLLPAVQRALFVRLTQRYQEDEEQTSTQPHRAPSKEEDDTVNWYSSSEEEEGSSVKSILKTLQKQTETLRNQQQPSTELSTPTDPRLAKEKSKGNQVVDPRLRTIPRQDIRKPSESAPLDLRLAWDPRKLRGNGSGHIGSSVGGAKFDLHHANAGTNVKHKRGDDDDEDTERELREKAFLIPLDASPGIMLQDPRSQLRQFSHIKMDITLTKPNFAKHIVWAPEDLLPVPLPKPDPVSSINLPLPPLIADQRLNRLWNTKSDLHQNTVSIDPKLAAKAKINTTNREGYLEQFGDSHGSGAKLGDPRLQKNFDPRLHRLPNTESHQVVMKDSHASKGAPHLPRSNPGSSQPSGAGTSNSGSGALPPYAPKLSSSAGLPLGTSTSVLSGISLYDPRDHGSSSTSELATASSGENSKNQKKSGGLKSSDKTEPSPGEAILPQKPSPNVGVTLEGPADPQADVPRSSGKVQVPAVHSLPVQALTGLIRPQYSDPRQARQPGQGSPTPDNDPGRETDDKSLKEVFKTFDPTASPFC"},{"id":"SEQ_04771","a":"Q9H322","g":"VCX2","d":"Variable charge X-linked protein 2","L":139,"m":[{"c":"[EP]L[PS][PQ]E[ES][EP]V[ES]E","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three 10-residue acidic/polar repeats in the C-terminal disordered tail sharing invariant L2, E5, V8, and E10 anchors, consisting of one divergent upstream copy followed after a 5-aa linker by two 100%-identical head-to-tail copies.","i":[[88,97,"ELPPEEPVSE"],[103,112,"PLSQESEVEE"],[113,122,"PLSQESEVEE"]]}],"s":"MSPKPRASGPPAKATEAGKRKSSSQPSPSDPKKKTTKVAKKGKAVRRGRRGKKGAATKMAAVTAPEAESAPAAPGPSDQPSQELPQHELPPEEPVSEGTQHDPLSQESEVEEPLSQESEVEEPLTVWMASFSPVSESTD"},{"id":"SEQ_04775","a":"Q96GW7","g":"BCAN","d":"Brevican core protein","L":911,"m":[{"c":"G[VE]ψFL(x){15,18}CxxxGA[HE]IAT[PT][EG]QLYAAΩxGGφ-[QH]C[DS][AP]GWL[SA]D[QG]oVRYPIxTP[RS][EQ][AR]C(x){2,5}GφPGV+oφxψφ(x){7,14}VYCΩ","u":"96-97","sp":"periodic","x":"structured_like","cf":"high","why":"Two highly conserved ~96-97 aa globular domain repeats separated by a short 5-aa linker (AEDLN), anchored by four invariant cysteines, an ungapped 46-aa central core (GAxIATxxQLYAAΩxGGφ-xCxxGWLxDxxVRYPIxTPxxxC), a GφPGV+oφ motif, and a C-terminal VYCΩ motif.","i":[[156,251,"GVVFLYREGSARYAFSFSGAQEACARIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREACYGDMDGFPGVRNYGVVDPDDLYDVYCY"],[257,353,"GELFLGDPPEKLTLEEARAYCQERGAEIATTGQLYAAWDGGLDHCSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFLFPNQTGFPNKHSRFNVYCF"]]}],"s":"MAQLFLPLLAALVLAQAPAALADVLEGDSSEDRAFRVRIAGDAPLQGVLGGALTIPCHVHYLRPPPSRRAVLGSPRVKWTFLSRGREAEVLVARGVRVKVNEAYRFRVALPAYPASLTDVSLALSELRPNDSGIYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSARYAFSFSGAQEACARIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREACYGDMDGFPGVRNYGVVDPDDLYDVYCYAEDLNGELFLGDPPEKLTLEEARAYCQERGAEIATTGQLYAAWDGGLDHCSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFLFPNQTGFPNKHSRFNVYCFRDSAQPSAIPEASNPASNPASDGLEAIVTVTETLEELQLPQEATESESRGAIYSIPIMEDGGGGSSTPEDPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEEEEEVEDEALWAWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDGESEASRPPRVHGPPTETLPTPRERNLASPSPSTLVEAREVGEATGGPELSGVPRGESEETGSSEGAPSLLPATRAPEGTRELEAPSEDNSGRTAPAGTSVQAQPVLPTDSASRGGVAVVPASGDCVPSPCHNGGTCLEEEEGVRCLCLPGYGGDLCDVGLRFCNPGWDAFQGACYKHFSTRRSWEEAETQCRMYGAHLASISTPEEQDFINNRYREYQWIGLNDRTIEGDFLWSDGVPLLYENWNPGQPDSYFLSGENCVVMVWHDQGQWSDVPCNYHLSYTCKMGLVSCGPPPELPLAQVFGRPRLRYEVDTVLRYRCREGLAQRNLPLIRCQENGRWEAPQISCVPRRPARALHPEEDPEGRQGRLLGRWKALLIPPSSPMPGP"},{"id":"SEQ_04783","a":"Q96QE4","g":"LRRC37B","d":"Leucine-rich repeat-containing protein 37B","L":947,"m":[{"c":"φxxxψ[DNI]φxx[NT]xψ[STR]xxxxxxφ(x){4,7}","u":"24-27","sp":"tandem","x":"structured_like","cf":"high","why":"Six head-to-tail tandem 24-27 aa leucine-rich repeat units sharing a conserved hydrophobic/asparagine beta-strand register (φxxxψ[DNI]φxx[NT]xψ[STR]) and a conserved position-20 hydrophobic anchor.","i":[[556,579,"IFTTLNFQGNYISYLDGNVWKAYS"],[580,603,"WTEKLILSENYLTELPKDSFEGLL"],[604,627,"YLQYLDLSCNKIRYIERQTFESLP"],[628,654,"FLQYINLGCNLITKLSLGTFQAWHGMQ"],[655,678,"FLHNLILNRNPLTTVEDPYLFELP"],[679,703,"ALKYLDMGTTHITLTTLKNILTMTV"]]},{"c":"Q[QE]EAP[AI][QL]","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 7-aa motifs in the proline/polar-rich disordered region sharing four invariant anchor positions (Q, E, A, P) and three tightly constrained binary positions.","i":[[281,287,"QEEAPAQ"],[300,306,"QQEAPAL"],[366,372,"QQEAPIQ"]]},{"c":"[PT][ES]PTTE","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three clustered, non-overlapping 6-aa motifs in the Ser/Thr/Pro-rich disordered stalk anchored by an invariant PTTE core and N-terminal [PT][ES] positions.","i":[[427,432,"TEPTTE"],[435,440,"PSPTTE"],[455,460,"PEPTTE"]]}],"s":"MSWLRFWGPWPLLTWQLLSLLVKEAQPLVWVKDPLQLTSNPLGPPEPWSSRSSHLPWESPHAPAPPAAPGDFDYLGPSASSQMSALPQEPTENLAPFLKELDSAGELPLGPEPFLAAHQDLNDKRTPEERLPEVVPLLNRDQNQALVQLPRLKWVQTTDLDRAAGHQADEILVPLDSKVSRPTKFVVSPKNLKKDLAERWSLPEIVGIPHQLSKPQRQKQTLPDDYLSMDTLYPGSLPPELRVNADEPPGPPEQVGLSQFHLEPKSQNPETLEDIQSSSLQEEAPAQLLQLPQEVEPSTQQEAPALPPESSMESLAQTPLNHEVTVQPPGEDQAHYNLPKFTVKPADVEVTMTSEPKNETESTQAQQEAPIQPPEEAEPSSTALRTTDPPPEHPEVTLPPSDKGQAQHSHLTEATVQPLDLELSITTEPTTEVKPSPTTEETSAQPPDPGLAITPEPTTEIGHSTALEKTRAPHPDQVQTLHRSLTEVTGPPTKLESSQDSLVQSETAPEEQKASTSTNICELCTCGDETLSCVGLSPKQRLRQVPVPEPDTYNGIFTTLNFQGNYISYLDGNVWKAYSWTEKLILSENYLTELPKDSFEGLLYLQYLDLSCNKIRYIERQTFESLPFLQYINLGCNLITKLSLGTFQAWHGMQFLHNLILNRNPLTTVEDPYLFELPALKYLDMGTTHITLTTLKNILTMTVELEKLILPSHMACCLCQFKNSIEAVCKTVKLHCNTACLTNSIHCPEEASVGNPEGAFMKMLQARKQHMSTQLTIESEAPSDSSGINLSGFGGDQLEIQLTEQLRSLIPNEDVRKFMSHVIRTLKMECSETHVQGSCAKLMLRTGLLMKLLSEQQEAKALNVEWDTDQQKTNYINENMEQNEQKEQKSSELMKEVPGDDYKNKLIFAISVTVILIILIIIFCLIEVNSHKRASEKYKDNPSISGA"},{"id":"SEQ_04795","a":"O95271","g":"TNKS","d":"Poly [ADP-ribose] polymerase tankyrase-1","L":1327,"m":[{"c":"xxxxx[PA]LHxA[ACV](x){4,7}xxxxxxLxxx[GN][AST]x[VPM]xxx[DNS]","u":"33-36","sp":"dispersed","x":"structured_like","cf":"high","why":"Fifteen 33-36 aa structured repeats (14 of 33 aa and one 36 aa variant with a 3-residue loop insertion) strongly anchored by invariant L7, H8, A10, and L22 alongside conserved [PA]6, [ACV]11, [GN]26, [AST]27, [VPM]29, and [DNS]33 positions. The copies are organized into five head-to-tail 3-repeat clusters separated by 54-60 aa diverged N/C-capping segments.","i":[[214,246,"GRKSSPLHFAAGFGRKDVVEHLLQMGANVHARD"],[247,279,"DGGLIPLHNACSFGHAEVVSLLLCQGADPNARD"],[280,312,"NWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRN"],[367,399,"GRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKD"],[400,432,"KGGLVPLHNACSYGHYEVTELLLKHGACVNAMD"],[433,465,"LWQFTPLHEAASKNRVEVCSLLLSHGADPTLVN"],[520,555,"QSHETALHCAVASLHPKRKQVTELLLRKGANVNEKN"],[556,588,"KDFMTPLHVAAERAHNDVMEVLHKHGAKMNALD"],[589,621,"TLGQTALHRAALAGHLQTCRLLLSYGSDPSIIS"],[682,714,"GRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKD"],[715,747,"KGGLVPLHNACSYGHYEVAELLVRHGASVNVAD"],[748,780,"LWKFTPLHEAAAKGKYEICKLLLKHGADPTKKN"],[835,867,"GRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQD"],[868,900,"KGGLIPLHNAASYGHVDIAALLIKYNTCVNATD"],[901,933,"KWAFTPLHEAAQKGRTQLCALLLAHGADPTMKN"]]}],"s":"MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQKT"},{"id":"SEQ_04801","a":"Q6KC79","g":"NIPBL","d":"Nipped-B-like protein","L":2804,"m":[{"c":"[GSN][RH]PETPK[QHK]+x-","u":11,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Seven 11-aa repeats in the central disordered region anchored by an invariant PETPK core, flanking [GSN][RH] N-terminal residues, a basic (+) position, and a C-terminal acidic (-) residue; six copies form a head-to-tail tandem array (residues 698-763) preceded by one upstream copy (residues 594-604).","i":[[595,605,"NHPETPKKKSD"],[698,708,"SRPETPKQKGE"],[709,719,"SRPETPKQKSD"],[720,730,"GHPETPKQKGD"],[731,741,"GRPETPKQKGE"],[742,752,"SRPETPKQKNE"],[753,763,"GRPETPKHRHD"]]},{"c":"-xK[QPS][NS]-[NS][KRT]x","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Seven 9-aa repeats located between the two [GSN][RH]PETPK[QHK]+x- segments (residues 612-688), conserved at an invariant Lys anchor, two acidic (-) positions, and two [NS] polar positions, arranged as two 1-aa-spaced clusters separated by a 9-aa degenerate linker (ETKVETQTE).","i":[[612,620,"EMKQSESRL"],[622,630,"ESKPNENRL"],[632,640,"ETKSSENKL"],[650,658,"ELKQNESRT"],[660,668,"ECKQNESTI"],[670,678,"EPKQNENRL"],[680,688,"DTKPNDNKQ"]]}],"s":"MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEGDIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAPQSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTDKTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYPQYDPVYRLDPHGGGLLSSKAKRAKCSTHKQRVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTAVFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQCVVHLPSSEKDSNAEEDSNKKIDQDVVITNSYETAMRTAQNFLSIFLKKCGSKQGEEDYRPLFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARLRKDAVTSKMDQGSIERILKQVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQKDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVVAVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVEHILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLEDFKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLKNLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQQLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRRSKRNSDSTELAAQMNESVDVMDVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKESDIIYKKIALTSANKLTNKVVQTLRSLYAAKDGTSS"},{"id":"SEQ_04813","a":"P57679","g":"EVC","d":"EvC complex member EVC","L":992,"m":[{"c":"xxxxxxxxxxxx[AH]xW[KQ]xxxxxxxxxxxxxx(x){6,8}xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxφxφxxxφxxxxxxxx[LF]","u":"110-112","sp":"dispersed","x":"structured_like","cf":"high","why":"Four ~110-112 aa alpha-helical bundle repeats separated by short variable linkers (2-27 aa), anchored by an invariant N-terminal helix tryptophan signature ([AH]xW[KQ] at positions 13-16) and a conserved C-terminal hydrophobic register (φxφxxxφxxxxxxxx[LF]).","i":[[304,413,"REYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKL"],[416,525,"RQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYF"],[553,664,"ECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRL"],[679,789,"ALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRL"]]}],"s":"MARGGAACKSDARLLLGRDALRPAPALLAPAVLLGAALGLGLGLWLGCRAGRQRTRHQKDDTQNLLKNLESNAQTPSETGSPSRRRKREVQMSKDKEAVDECEPPSNSNITAFALKAKVIYPINQKFRPLADGSSNPSLHENLKQAVLPHQPVEASPSSSLGSLSQGEKDDCSSSSSVHSATSDDRFLSRTFLRVNAFPEVLACESVDVDLCIYSLHLKDLLHLDTALRQEKHMMFIQIFKMCLLDLLPKKKSDDELYQKILSKQEKDLEELEKGLQVKLSNTEMSGAGDSEYITLADVEKKEREYSEQLIDNMEAFWKQMANIQHFLVDQFKCSSSKARQLMMTLTERMIAAEGLLCDSQELQALDALERTMGRAHMAKVIEFLKLQVQEETRCRLAAISHGLELLAGEGKLSGRQKEELLTQQHKAFWQEAERFSREFVQRGKDLVTASLAHQVEGTAKLTLAQEEEQRSFLAEAQPTADPEKFLEAFHEVLERQRLMQCDLEEEENVRATEAVVALCQELYFSTVDTFQKFVDALFLQTLPGMTGLPPEECDYLRQEVQENAAWQLGKSNRFRRQQWKLFQELLEQDQQVWMEECALSSVLQTHLREDHEGTIRGVLGRLGGLTEESTRCVLQGHDLLLRSALRRLALRGNALATLTQMRLSGKKHLLQELREQRALEQGSSQCLDEHQWQLLRALEARVLEEASRLEEEAQQTRLQLQQRLLAEAQEVGQLLQQHMECAIGQALLVHARNAATKSRAKDRDDFKRTLMEAAVESVYVTSAGVSRLVQAYYQQIGRIMEDHEERKLQHLKTLQGERMENYKLRKKQELSNPSSGSRTAGGAHETSQAVHQRMLSQQKRFLAQFPVHQQMRLHAQQQQAGVMDLLEAQLETQLQEAEQNFISELAALARVPLAESKLLPAKRGLLEKPLRTKRKKPLPQERGDLGVPNNEDLASGDQTSGSLSSKRLSQQESEAGDSGNSKKMLKRRSNL"},{"id":"SEQ_04819","a":"Q15021","g":"NCAPD2","d":"Condensin complex subunit 1","L":1401,"m":[{"c":"xxxxxxxxxxφxxxxx[DS]xxxx[VI][RA]xxφxxφxxx[LI]xxxx","u":37,"sp":"dispersed","x":"structured_like","cf":"high","why":"Five 37-aa alpha-helical solenoid (HEAT-like) repeat units featuring an amphipathic A-helix with a conserved hydrophobic core residue, a [DS]/Pro-enriched inter-helix turn, and a strongly conserved B-helix anchored by a [VI][RA]xxφxxφxxx[LI] register. The C-terminal three copies (residues 1050-1160) form a contiguous head-to-tail tandem array while two additional well-conserved copies occur earlier in the structured solenoid.","i":[[359,395,"RDTRDQFLDTLQAHGHDVNSFVRSRVLQLFTRIVQQK"],[668,704,"VPQALFGVRRMLPLIWSKEPGVREAVLNAYRQLYLNP"],[1050,1086,"TFCDSQLRLLFTMLEKSPLPIVRSNLMVATGDLAIRF"],[1087,1123,"PNLVDPWTPHLYARLRDPAQQVRKTAGLVMTHLILKD"],[1124,1160,"MVKVKGQVSEMAVLLIDPEPQIAALAKNFFNELSHKG"]]}],"s":"MAPQMYEFHLPLSPEELLKSGGVNQYVVQEVLSIKHLPPQLRAFQAAFRAQGPLAMLQHFDTIYSILHHFRSIDPGLKEDTLQFLIKVVSRHSQELPAILDDTTLSGSDRNAHLNALKMNCYALIRLLESFETMASQTNLVDLDLGGKGKKARTKAAHGFDWEEERQPILQLLTQLLQLDIRHLWNHSIIEEEFVSLVTGCCYRLLENPTINHQKNRPTREAITHLLGVALTRYNHMLSATVKIIQMLQHFEHLAPVLVAAVSLWATDYGMKSIVGEIVREIGQKCPQELSRDPSGTKGFAAFLTELAERVPAILMSSMCILLDHLDGENYMMRNAVLAAMAEMVLQVLSGDQLEAAARDTRDQFLDTLQAHGHDVNSFVRSRVLQLFTRIVQQKALPLTRFQAVVALAVGRLADKSVLVCKNAIQLLASFLANNPFSCKLSDADLAGPLQKETQKLQEMRAQRRTAAASAVLDPEEEWEAMLPELKSTLQQLLQLPQGEEEIPEQIANTETTEDVKGRIYQLLAKASYKKAIILTREATGHFQESEPFSHIDPEESEETRLLNILGLIFKGPAASTQEKNPRESTGNMVTGQTVCKNKPNMSDPEESRGNDELVKQEMLVQYLQDAYSFSRKITEAIGIISKMMYENTTTVVQEVIEFFVMVFQFGVPQALFGVRRMLPLIWSKEPGVREAVLNAYRQLYLNPKGDSARAKAQALIQNLSLLLVDASVGTIQCLEEILCEFVQKDELKPAVTQLLWERATEKVACCPLERCSSVMLLGMMARGKPEIVGSNLDTLVSIGLDEKFPQDYRLAQQVCHAIANISDRRKPSLGKRHPPFRLPQEHRLFERLRETVTKGFVHPDPLWIPFKEVAVTLIYQLAEGPEVICAQILQGCAKQALEKLEEKRTSQEDPKESPAMLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELCRRRVLREEQEHKTKDPKEKNTSSETTMEEELGLVGATADDTEAELIRGICEMELLDGKQTLAAFVPLLLKVCNNPGLYSNPDLSAAASLALGKFCMISATFCDSQLRLLFTMLEKSPLPIVRSNLMVATGDLAIRFPNLVDPWTPHLYARLRDPAQQVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPEPQIAALAKNFFNELSHKGNAIYNLLPDIISRLSDPELGVEEEPFHTIMKQLLSYITKDKQTESLVEKLCQRFRTSRTERQQRDLAYCVSQLPLTERGLRKMLDNFDCFGDKLSDESIFSAFLSVVGKLRRGAKPEGKAIIDEFEQKLRACHTRGLDGIKELEIGQAGSQRAPSAKKPSTGSRYQPLASTASDNDFVTPEPRRTTRRHPNTQQRASKKKPKVVFSSDESSEEDLSAEMTEDETPKKTTPILRASARRHRS"},{"id":"SEQ_04820","a":"Q6P4R8","g":"NFRKB","d":"Nuclear factor related to kappa-B-binding protein","L":1299,"m":[{"c":"[RA][IL][TMV]xxL[GS]V(x){4,6}G[KQN][ST][ITV](x){1,3}A[TSP]","u":"21-22","sp":"dispersed","x":"mixed","cf":"high","why":"Four dispersed 21-22 aa repeats in the C-terminal P/S/T/A-rich region share two conserved bipartite blocks—an N-terminal [RA][IL][TMV]xxL[GS]V motif with invariant L and V anchors and a C-terminal G[KQN][ST][ITV](x){1,3}A[TSP] motif with invariant G and A—separated by a 4-6 residue proline-containing linker.","i":[[923,943,"AITGQLGVKPQTGNSIPLTAT"],[1059,1079,"RLMPALGVSVADQKGKSTVAS"],[1089,1109,"RIVQGLGVMPPKAGQTITVAT"],[1183,1204,"RITVPLSVISQPMKGKSVVTAP"]]}],"s":"MDSLDHMLTDPLELGPCGDGHGTRIMEDCLLGGTRVSLPEDLLEDPEIFFDVVSLSTWQEVLSDSQREHLQQFLPQFPEDSAEQQNELILALFSGENFRFGNPLHIAQKLFRDGHFNPEVVKYRQLCFKSQYKRYLNSQQQYFHRLLKQILASRSDLLEMARRSGPALPFRQKRPSPSRTPEEREWRTQQRYLKVLREVKEECGDTALSSDEEDLSSWLPSSPARSPSPAVPLRVVPTLSTTDMKTADKVELGDSDLKIMLKKHHEKRKHQPDHPDLLTGDLTLNDIMTRVNAGRKGSLAALYDLAVLKKKVKEKEEKKKKKIKTIKSEAEDLAEPLSSTEGVAPLSQAPSPLAIPAIKEEPLEDLKPCLGINEISSSFFSLLLEILLLESQASLPMLEERVLDWQSSPASSLNSWFSAAPNWAELVLPALQYLAGESRAVPSSFSPFVEFKEKTQQWKLLGQSQDNEKELAALFQLWLETKDQAFCKQENEDSSDATTPVPRVRTDYVVRPSTGEEKRVFQEQERYRYSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTILSLVRDAAARLPNGEGTRAEICELLKDSQFLAPDVTSTQVNTVVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFERIHQAQAAAAKARKALQQKPKPPSKVKSSSKESSIKVLSSGPSEQSQMSLSDSSMPPTPVTPVTPTTPALPAIPISPPPVSAVNKSGPSTVSEPAKSSSGVLLVSSPTMPHLGTMLSPASSQTAPSSQAAARVVSHSGSAGLSQVRVVAQPSLPAVPQQSGGPAQTLPQMPAGPQIRVPATATQTKVVPQTVMATVPVKAQTTAATVQRPGPGQTGLTVTSLPATASPVSKPATSSPGTSAPSASTAAVIQNVTGQNIIKQVAITGQLGVKPQTGNSIPLTATNFRIQGKDVLRLPPSSITTDAKGQTVLRITPDMMATLAKSQVTTVKLTQDLFGTGGNTTGKGISATLHVTSNPVHAADSPAKASSASAPSSTPTGTTVVKVTPDLKPTEASSSAFRLMPALGVSVADQKGKSTVASSEAKPAATIRIVQGLGVMPPKAGQTITVATHAKQGASVASGSGTVHTSAVSLPSMNAAVSKTVAVASGAASTPISISTGAPTVRQVPVSTTVVSTSQAGKLPTRITVPLSVISQPMKGKSVVTAPIIKGNLGANLSGLGRNIILTTMPAGTKLIAGNKPVSFLTAQQLQQLQQQGQATQVRIQTVPASHLQQGTASGSSKAVSTVVVTTAPSPKQAPEQQ"},{"id":"SEQ_04822","a":"Q9Y6X9","g":"MORC2","d":"ATPase MORC2","L":1032,"m":[{"c":"[PS]R[PS][PA][PS]L[PV]","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 7-aa proline-rich motifs in the central disordered region (residues 613-692) align with zero unconstrained positions around invariant R (pos 2) and L (pos 6) anchors separated by three P/S/A residues.","i":[[613,619,"PRSPPLP"],[627,633,"SRPPSLP"],[686,692,"SRPAPLV"]]}],"s":"MAFTNYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDADATRIDIYAERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGIDEVIVPLPTWNARTREPVTDNVEKFAIETELIYKYSPFRTEEEVMTQFMKIPGDSGTLVIIFNLKLMDNGEPELDIISNPRDIQMAETSPEGTKPERRSFRAYAAVLYIDPRMRIFIHGHKVQTKRLSCCLYKPRMYKYTSSRFKTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRLGGDLTRDSRVMLRQVQNRAITLRREADVKKRIKEAKQRALKEPKELNFVFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACGGVVGVVDVPYLVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYWKDIAIAQRGIIKFWDEFGYLSANWNQPPSSELRYKRRRAMEIPTTIQCDLCLKWRTLPFQLSSVEKDYPDTWVCSMNPDPEQDRCEASEQKQKVPLGTFRKDMKTQEEKQKQLTEKIRQQQEKLEALQKTTPIRSQADLKKLPLEVTTRPSTEEPVRRPQRPRSPPLPAVIRNAPSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREEASTSRLLQPPEAPRKPANTLVKTASRPAPLVQQLSPSLLPNSKSPREVPSPKVIKTPVVKKTESPIKLSPATPSRKRSVAVSDEEEVEEEAERRKERCKRGRFVVKEEKKDSNELSDSAGEEDSADLKRAQKDKGLHVEVRVNREWYTGRVTAVEVGKHVVRWKVKFDYVPTDTTPRDRWVEKGSEDVRLMKPPSPEHQSLDTQQEGGEEEVGPVAQQAIAVAEPSTSECLRIEPDTTALSTNHETIDLLVQILRNCLRYFLPPSFPISKKQLSAMNSDELISFPLKEYFKQYEVGLQNLCNSYQSRADSRAKASEESLRTSERKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKGD"},{"id":"SEQ_04848","a":"P51116","g":"FXR2","d":"RNA-binding protein FXR2","L":673,"m":[{"c":"LψGxφIGxxGxxIQ[QE]φxxx[PS]GV[TV]xψxψ[GE][EG]-(x){3,13}FxφφG[ET][TR][PE](x){7,8}φLEΩ","u":"53-62","sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 53-62 aa structured domain repeats separated by a 10 aa linker, anchored by an invariant LψGxφIGxxGxxIQ N-terminal core, a GV[TV]xψxψ motif, a variable loop of 3-13 residues, and a C-terminal FxφφG...(x){7,8}φLEΩ segment.","i":[[239,291,"LMGLAIGTHGANIQQARKVPGVTAIELGEETCTFRIYGETPEACRQARSYLEF"],[302,363,"LVGKVIGKNGKVIQEIVDKSGVVRVRVEGDNDKKNPREEGMVPFIFVGTRENISNAQALLEY"]]}],"s":"MGGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPPPADYNKEITEGDEVEVYSRANEQEPCGWWLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREACSNENVHKEFKKALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKHLETSKQLAAAFQEEFTVREDLMGLAIGTHGANIQQARKVPGVTAIELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDNDKKNPREEGMVPFIFVGTRENISNAQALLEYHLSYLQEVEQLRLERLQIDEQLRQIGLGFRPPGSGRGSGGSDKAGYSTDESSSSSLHATRTYGGSYGGRGRGRRTGGPAYGPSSDVSTASETESEKREEPNRAGPGDRDPPTRGEESRRRPTGGRGRGPPPAPRPTSRYNSSSISSVLKDPDSNPYSLLDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGGLESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTVADYISRAESQSRQRPPLERTKPSEDSLSGQKGDSVSKLPKGPSENGELSAPLELGSMVNGVS"},{"id":"SEQ_04875","a":"Q2M3C7","g":"SPHKAP","d":"A-kinase anchor protein SPHKAP","L":1700,"m":[{"c":"K[AQ]SS[CT]ESI[PT]-E[DF][SY](x){0,2}Rφ[MY][VL][NR]xψ","u":"20-22","sp":"dispersed","x":"mixed","cf":"high","why":"Three dispersed 20-22 aa repeats in the C-terminal half (separated by 15 aa and 45 aa linkers) anchored by an invariant KxSSxESIx-E polar N-terminal core and a conserved C-terminal Rφ[MY][VL][NR]xψ amphipathic helical segment, with a 2-residue insertion in the first copy.","i":[[1079,1100,"KASSCESIPEEDSEARAYVNSL"],[1118,1137,"KQSSCESITDEFSRFMVNQM"],[1183,1202,"KQSSTESITEEFYRYMLRDI"]]}],"s":"MDGNSLLSVPSNLESSRMYDVLEPQQGRGCGSSGSGPGNSITACKKVLRSNSLLESTDYWLQNQRMPCQIGFVEDKSENCASVCFVNLDVNKDECSTEHLQQKLVNVSPDLPKLISSMNVQQPKENEIVVLSGLASGNLQADFEVSQCPWLPDICLVQCARGNRPNSTNCIIFEINKFLIGLELVQERQLHLETNILKLEDDTNCSLSSIEEDFLTASEHLEEESEVDESRNDYENINVSANVLESKQLKGATQVEWNCNKEKWLYALEDKYINKYPTPLIKTERSPENLTKNTALQSLDPSAKPSQWKREAVGNGRQATHYYHSEAFKGQMEKSQALYIPKDAYFSMMDKDVPSACAVAEQRSNLNPGDHEDTRNALPPRQDGEVTTGKYATNLAESVLQDAFIRLSQSQSTLPQESAVSVSVGSSLLPSCYSTKDTVVSRSWNELPKIVVVQSPDGSDAAPQPGISSWPEMEVSVETSSILSGENSSRQPQSALEVALACAATVIGTISSPQATERLKMEQVVSNFPPGSSGALQTQAPQGLKEPSINEYSFPSALCGMTQVASAVAVCGLGEREEVTCSVAPSGSLPPAAEASEAMPPLCGLASMELGKEAIAKGLLKEAALVLTRPNTYSSIGDFLDSMNRRIMETASKSQTLCSENVVRNELAHTLSNVILRHSIDEVHHKNMIIDPNDNRHSSEILDTLMESTNQLLLDVICFTFKKMSHIVRLGECPAVLSKETIRRRETEPSCQPSDPGASQAWTKATESSSSSPLSNSHNTSLVINNLVDGMYSKQDKGGVRPGLFKNPTLQSQLSRSHRVPDSSTATTSSKEIYLKGIAGEDTKSPHHSENECRASSEGQRSPTVSQSRSGSQEAEESIHPNTQEKYNCATSRINEVQVNLSLLGDDLLLPAQSTLQTKHPDIYCITDFAEELADTVVSMATEIAAICLDNSSGKQPWFCAWKRGSEFLMTPNVPCRSLKRKKESQGSGTAVRKHKPPRLSEIKRKTDEHPELKEKLMNRVVDESMNLEDVPDSVNLFANEVAAKIMNLTEFSMVDGMWQAQGYPRNRLLSGDRWSRLKASSCESIPEEDSEARAYVNSLGLMSTLSQPVSRASSVSKQSSCESITDEFSRFMVNQMENEGRGFELLLDYYAGKNASSILNSAMQQACRKSDHLSVRPSCPSKQSSTESITEEFYRYMLRDIERDSRESASSRRSSQDWTAGLLSPSLRSPVCHRQSSMPDSRSPCSRLTVNVPIKANSLDGFAQNCPQDFLSVQPVSSASSSGLCKSDSCLYRRGGTDHITNMLIHETWASSIEALMRKNKIIVDDAEEADTEPVSGGSPSQAEKCANRLAASRMCSGPTLLVQESLDCPRKDSVTECKQPPVSSLSKTASLTNHSPLDSKKETSSCQDPVPINHKRRSLCSREVPLIQIETDQREACAGEPEPFLSKSSLLEEAEGHSNDKNIPDVVRGGDTAVSACQIHSDSLDTRDVPEAEASTEARAPDEAPNPPSSSEESTGSWTQLANEEDNPDDTSSFLQLSERSMSNGNSSATSSLGIMDLDIYQESMPSSPMINELVEEKKILKGQSESTEAPASGPPTGTASPQRSLLVINFDLEPECPDAELRATLQWIAASELGIPTIYFKKSQENRIEKFLDVVQLVHRKSWKVGDIFHAVVQYCKMHEEQKDGRLSLFDWLLELG"},{"id":"SEQ_04890","a":"Q8TC90","g":"CCER1","d":"Coiled-coil domain-containing glutamate-rich protein 1","L":406,"m":[{"c":"EEEEV[EL]-","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Four copies of a 7-residue acidic repeat anchored by an invariant Val at position 5 (EEEEV[EL]-) occur within the C-terminal glutamate-rich disordered region, with three tandem copies (residues 303-324) followed by a fourth copy (342-348) after a linker containing two degenerate EEELE units.","i":[[303,309,"EEEEVED"],[310,316,"EEEEVED"],[318,324,"EEEEVEE"],[342,348,"EEEEVLE"]]}],"s":"MTQTLDTREDPLNLGGGGGGGCGCGWAHSASLSSWSSCHRRRPGAPAYNRPHRYSPKTEYGPPRKQPKQQHGPGFWFQPPVCSNWGCWGGPWRPPPPGFWKFPCPVQVFRVYGLHPLCFCCCSCWSGSWNPGWVKPPGRKKRWGRRGRGLRHHPRHSYPRSPPADVSTLPRPVKLYEWREPGMRAPPNTTQFIMNQIYEDMRQQEKVERQQEALRAQKATVSGEASPARSSGNDAPPGGSKETWGLQETLYGFVQNPSLAFSPNPEENQSLAPLLVEEEEEKKNDDEEEYDQEVCDAKEASEEEEEVEDEEEEVEDEEEEEVEEAEYVEEGEEELEEEELEEEEEVLEENEQRGEEFHLPLEMPLSIFVEAEEKRENFISCTFLNPEQIIPKVPQESLFMAQDFNC"},{"id":"SEQ_04911","a":"Q9UKP4","g":"ADAMTS7","d":"A disintegrin and metalloproteinase with thrombospondin motifs 7","L":1686,"m":[{"c":"W(x){4,5}WxxC[ST]xxCGxG(x){7,8}C(x){5,16}C(x){9,12}C(x){4,5}C","u":"47-60","sp":"dispersed","x":"structured_like","cf":"high","why":"Eight copies of a 47-60 aa cysteine-rich structured repeat anchored by an N-terminal W(x){4,5}Wxx motif, an invariant C[ST]xxCGxG core, and four downstream conserved cysteines ending in a C(x){4,5}C pair. Copies are organized into one N-terminal unit plus two C-terminal tandem clusters (3 and 4 units separated by 2-3 aa linkers) flanking a long central proline/serine-rich linker.","i":[[541,592,"WSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQAC"],[825,879,"WHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPC"],[883,942,"WWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPC"],[946,994,"WAVGNWSQCSVTCGEGTQRRNVLCTNDTGVPCDEAQQPASEVTCSLPLC"],[1415,1463,"WQAGNWSECSTTCGLGAVWRPVRCSSGRDEDCAPAGRPQPARRCHLRPC"],[1466,1521,"WHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC"],[1524,1570,"WYTSSWRECSEACGGGEQQRLVTCPEPGLCEEALRPNTTRPCNTHPC"],[1573,1628,"WVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC"]]}],"s":"MPGGPSPRSPAPLLRPLLLLLCALAPGAPGPAPGRATEGRAALDIVHPVRVDAGGSFLSYELWPRALRKRDVSVRRDAPAFYELQYRGRELRFNLTANQHLLAPGFVSETRRRGGLGRAHIRAHTPACHLLGEVQDPELEGGLAAISACDGLKGVFQLSNEDYFIEPLDSAPARPGHAQPHVVYKRQAPERLAQRGDSSAPSTCGVQVYPELESRRERWEQRQQWRRPRLRRLHQRSVSKEKWVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLDRGWGLCLDDPPAKDIIDFPSVPPGVLYDVSHQCRLQYGAYSAFCEDMDNVCHTLWCSVGTTCHSKLDAAVDGTRCGENKWCLSGECVPVGFRPEAVDGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLYKGQLHTWVPVVNDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAEGLGYVDVGLIPAGAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRGNWENLTSPGPTKEPVWIQLLFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGVPCDEAQQPASEVTCSLPLCRWPLGTLGPEGSGSGSSSHELFNEADFIPHHLAPRPSPASSPKPGTMGNAIEEEAPELDLPGPVFVDDFYYDYNFINFHEDLSYGPSEEPDLDLAGTGDRTPPPHSHPAAPSTGSPVPATEPPAAKEEGVLGPWSPSPWPSQAGRSPPPPSEQTPGNPLINFLPEEDTPIGAPDLGLPSLSWPRVSTDGLQTPATPESQNDFPVGKDSQSQLPPPWRDRTNEVFKDDEEPKGRGAPHLPPRPSSTLPPLSPVGSTHSSPSPDVAELWTGGTVAWEPALEGGLGPVDSELWPTVGVASLLPPPIAPLPEMKVRDSSLEPGTPSFPTPGPGSWDLQTVAVWGTFLPTTLTGLGHMPEPALNPGPKGQPESLSPEVPLSSRLLSTPAWDSPANSHRVPETQPLAPSLAEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSSGRDEDCAPAGRPQPARRCHLRPCATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTCPEPGLCEEALRPNTTRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCEPVEPPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCSPPSHGAPSRGHQRVARR"},{"id":"SEQ_04924","a":"Q8N7X1","g":"RBMXL3","d":"RNA-binding motif protein, X-linked-like-3","L":1067,"m":[{"c":"[GR]x[GE]G[RCH]YE(x){0,1}[YN][RQ]Gx[SL][LPH][DEN][AT]x[SG][GER][GD](x){8,34}[SGD]x[SN][DNH]x[YC]","u":"34-60","sp":"tandem","x":"disordered_like","cf":"high","why":"16-copy tandem repeat array in the C-terminal G/S/R/Y-rich disordered region (mostly 39 aa head-to-tail units, with one 32 aa N-terminally truncated remnant between copies 10 and 11), strongly anchored by an N-terminal GGG[RCH]YEE[YN][RQ]GxS[LP]DAxSGG motif, 0-2 internal GGRSPDAYS-like sub-modules, and a C-terminal [SGD]x[SN][DNH]x[YC] motif.","i":[[324,383,"GGGCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSDRY"],[384,417,"GEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHY"],[418,465,"GGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCC"],[466,504,"GGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWSDRY"],[505,547,"GVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNSYGQSHRY"],[548,585,"GGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRY"],[586,624,"GGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRY"],[625,663,"GGGGRYEEYRGRSLDANSGGRSPDAYSGGHDSSGQSNCY"],[664,702,"GGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQSNRY"],[703,741,"GGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHY"],[774,812,"GGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPC"],[813,855,"RGGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRY"],[856,907,"GGGGHYEEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHY"],[908,943,"GRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGRSHRY"],[944,977,"GGGGRYEEYRGPSPDAHSGGRDSSIKSYGLSDRY"],[978,1011,"GGGGHYEEYQGSLPDAYSGDHDRSSNSYGRSDRY"]]},{"c":"PR[HR]WA[SG]PPHKRA[TV]P(x){0,1}SSLA[HR]xxG[CS]GMxGKAP[TA]VxGQDGYSG","u":"40-41","sp":"tandem","x":"disordered_like","cf":"high","why":"Highly conserved 2-copy tandem duplication (29/40 identical positions, separated by a 2 aa LQ linker) upstream of the main repeat array, anchored by N-terminal PR[HR]WA[SG]PPHKRA[TV]P, internal SSLA and GMxGKAP, and C-terminal GQDGYSG.","i":[[154,193,"PRHWASPPHKRATPSSLAHSVGCGMRGKAPTVSGQDGYSG"],[196,236,"PRRWAGPPHKRAVPRSSLARIGGSGMPGKAPAVWGQDGYSG"]]}],"s":"MMEADRPEKLFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPADAKAAARDMNGKYLDGKAIMVAQTIKPAFKSSRWVPPTPGSGSRSRFSHRTRGGGSSPQRPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWASPPHKRATPSSLAHSVGCGMRGKAPTVSGQDGYSGLQPRRWAGPPHKRAVPRSSLARIGGSGMPGKAPAVWGQDGYSGPRVREPLPPCRDPGDFVPALRDYSRRYYGHSSVPDYRPLRGDGNQNGYRGRDHEYTDHPSKGSYREPLKSYGGPCGAAPVWGTPPSYGGGCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSGGRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGGGGRSLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCRGGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGGGHYEEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRDSSIKSYGLSDRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVGRPDRGLPLPMETGSPPLHDSYSRSGCRVPRGGGRQGGRFERGEGRSRY"},{"id":"SEQ_04935","a":"Q96HC4","g":"PDLIM5","d":"PDZ and LIM domain protein 5","L":596,"m":[{"c":"CxxCxxxI(x){2,4}x[FV][LI]xAL[GK]x[ST]WHx[EST][EC]F[NV]C[AVS]xCxx[PST]ψxxxxFxx[EK][KD][GD]x[LP][YL]C[EK]x[CDH][YA](x){3,4}F","u":"56-59","sp":"periodic","x":"structured_like","cf":"high","why":"Three C-terminal structured repeats separated by regular 3-residue linkers (APE, GTI), defined by paired CxxC...WH...CxxC...Cxx[CDH] cysteine/histidine motifs along with invariant I, AL, WH, and F core anchors.","i":[[420,475,"CAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFF"],[479,534,"CGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALF"],[538,596,"CHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSVNF"]]}],"s":"MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTSTNNMAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLHANANLSADQSPSALSAGKTAVNVPRQPTVTSVCSETSQELAEGQRRGSQGDSKQQNGPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSVNF"},{"id":"SEQ_04937","a":"P15391","g":"CD19","d":"B-lymphocyte antigen CD19","L":556,"m":[{"c":"[GAS]x[GSF]YE[NDE]","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Six dispersed occurrences in the acidic/polar C-terminal disordered region anchored by an invariant YE dipeptide flanked by a small N-terminal residue ([GAS]), a [GSF] pre-tyrosine position, and an Asn/acidic ([NDE]) C-terminal residue.","i":[[406,411,"GEGYEE"],[418,423,"SEFYEN"],[436,441,"GSGYEN"],[458,463,"AESYEN"],[497,502,"SQSYED"],[528,533,"ADSYEN"]]},{"c":"φLxCxxxxxxxxxxxL[TS]W[ST]xxxPxxPxxxLSL(x){26,28}GxY[LY]CxxG","u":"66-68","sp":"dispersed","x":"structured_like","cf":"medium","why":"Two N-terminal structured domain repeats separated by a 95-residue region, sharing aligned disulfide-like cysteine pairs (φLxC and GxY[LY]CxxG) and an internal L[TS]W[ST]xxxPxxPxxxLSL conserved segment.","i":[[35,100,"VLQCLKGTSDGPTQQLTWSRESPLKPFLKLSLGLPGLGIHMRPLAIWLFIFNVSQQMGGFYLCQPG"],[197,264,"WLSCGVPPDSVSRGPLSWTHVHPKGPKSLLSLELKDDRPARDMWVMETGLLLPRATAQDAGKYYCHRG"]]}],"s":"MPPPRLLFFLLFLTPMEVRPEEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKPFLKLSLGLPGLGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSGELFRWNVSDLGGLGCGLKNRSSEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCLPPRDSLNQSLSQDLTMAPGSTLWLSCGVPPDSVSRGPLSWTHVHPKGPKSLLSLELKDDRPARDMWVMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITARPVLWHWLLRTGGWKVSAVTLAYLIFCLCSLVGILHLQRALVLRRKRKRMTDPTRRFFKVTPPPGSGPQNQYGNVLSLPTPTSGLGRAQRWAAGLGGTAPSYGNPSSDVQADGALGSRSPPGVGPEEEEGEGYEEPDSEEDSEFYENDSNLGQDQLSQDGSGYENPEDEPLGPEDEDSFSNAESYENEDEELTQPVARTMDFLSPHGSAWDPSREATSLGSQSYEDMRGILYAAPQLRSIRGQPGPNHEEDADSYENMDNPDGPDPAWGGGGRMGTWSTR"},{"id":"SEQ_04942","a":"Q96M86","g":"DNHD1","d":"Dynein heavy chain domain-containing protein 1","L":4753,"m":[{"c":"[VL]xG[PEA]x[GA][VST]G+x[AT]xφxx[LA]","u":16,"sp":"dispersed","x":"structured_like","cf":"high","why":"Four dispersed 16-residue copies within structured segments share invariant G anchors at positions 3 and 8, a strictly conserved basic residue (+) at position 9, conserved hydrophobic/aliphatic positions at 1 ([VL]), 13 (φ), and 16 ([LA]), and tightly constrained small/polar choices at positions 4, 6, 7, and 11.","i":[[1685,1700,"VLGPNGVGKRAIVNSL"],[1990,2005,"LLGPAGSGKTTCWHSL"],[2386,2401,"LAGEAATGKSAFVEVL"],[2889,2904,"LSGALGTGRHTAITLA"]]}],"s":"MVPEERRVGLSSDETSSDSLKSWHSICVLDSKEQPLACQQKQRQFVKPVTESEQPTVLELLLAELRTLFSAVLQDSSPAAWRYLHAVLGLLPPYRELLVGHLDLLPFLEQLYCWAPWVQTHLHLDLLGAIVQAFPPDSSLLDSASHADCCPQKRRLHHRPPCPACPFVQAQWSRQQVKEELATWLRPLTLPELQRCLGIVGAQVALEEAVWLDGLSLLPLALAADIPVRYESSDTDNAEVEPVGRKETRSQLDYEVPREKAFQKSSTGFSPETSFLDSQVMTALKMERYLKKIHFLYLNVAPSRYFRPYSLMVVPPDKVNPEHYIFSPFGILHVHPVEGSETMTLGTWHHHCVLWQQLQFIPFFKYCLLRKSFTCWKKNVRLQGLHRLQKFLENHLLLAVPHFGAGLLHISRLLQELHSVSWLPQELDRCYELLDLQTALAEEKHKALRLLHRCLNLCTSILRLVHEDTYHMQQCLQERVQNCDRIRTGQGSIYLQRVQHKQLEQKLKQAEAWWLQLGKFARLVDYMICQSLISVLEEQITSFVANILQAPRQKPFLSSQLVFDDHGQLSHVPCVENMIQTLTGGLQSVKTSALQVVQSADLKTSSDSLYSEEEDEEEDSKDEFLMPKFQGQPSDAVSIFCGPNVGLVWPWKSHPIAGILEVRGCRLRGQYFPHNYKQLEEDLDNNPKIQQALNIQQVLLEGVLCKVQEFCREHHWITGIYEFLQSWGPQKLEDMRGGPIKNYVTLVSRLNVWQARVSSMPIELLTKGGLLLLSCHDVQAEMESKLNSIRKDILAHVQNECWNLSQQLMTELTDFMHIFRTINSDIHAIAQCTQKLNEANEQYVELEERMEYVRALHELIRNHFSLFSAENEALDISVRRQFGESPIPPCPPPPQPHLLHCPLLAPQLLDMWEAFQFEKSQASEFLLSKRHAIMPKLQQLMAAALAELEGLLAKALSGPFMDPTQDQRSTEHQLVSLERQFQNTVSDLSELHHAYAIFTEDETPVPLPICGTRPIVQQQRIWHLYRVISENISEWKCMAFAKFSPAMAQEKTEGWLTEAARMSTTLELHSPVLQHCMRILGEFRSYLPLLTKLGSLHPQSLNCQCLLRALGLGSLQTIELLTLGQLLTYPLLEFADRINQVWQNENERIHAQETIRRLQRYWEARQLRLLNFILHVPYEPPASERSKRQVLRSPQWEVVDKDSGTFILSDYSNLQDSIQESLQVLSKILAIEKSGDLNKIALEWVAIMHGLGALLEVWLTFQQKWIFLNKVLHEMKIQFPNADLNSRFKVMDDQYRTLMRISVADPMVLSLVVPSAERSPYFQGQQLQQLLQAGSVELEGIIMSLESVLYGVCAHFPRLFFLSDSELVALLAARLESCEAQLWVRRCFPHVHAVSFRSCPTGEKNTDDWESSPNTQTQVEALAVLGAGGEEVKLQGPLPLHPDLPKWLASLEKCLRLALVHMLQGCVAARLARGPSLGEALKQLPKQNKLYLQLYVQHWIDLVQAFPWQCVLVAEEVVWRAEMEEALLEWGTLAMVSMHMRKLEVLVNFMRAQRASQGGQSLPSVRQTSLLSALLVMAVTHRDIAQLLEQHQVSDLTDFHWVRQLKYHLGSPHIIPKSPLQSLKTIASSEPSLSPAACWIDVLGRSFLYNYEYLGPRLGPLPSLLPERPALVLLLALEEVACGTVLGPNGVGKRAIVNSLAQALGRQLVMLPCSPQIEAQCLSNYLNGALQGGAWLLLEKVHQLPPGLLSALGQRLGELHHLYAPLYQEASRNTSTIDPTQPQLLGSSFFEKHHVSVRLGYGCLLVLRALSSAVPANLHLLLRPVALALPDLRQVAELTLLGAGMRDAFQMATRLSKFFSLERELVSGPLPCRLPLLKQILEDTIRTLNVTKEEPKCQKPRSLAAIEEAALLRSPLFSILNGLHLHNLRGLLCALFPSASQVLAEPMTYKLMKPLVVEELQQVGLDPSPDILGSLEQLSQALSRASGILLLGPAGSGKTTCWHSLFKIQNRLAAMEDTSTQGCQPVEITHLYPSGLSPQEFLGWLEGSCWHHGIFPKVLRAAGQCNNMGQKRQTEESIGIQHWIICDGASNGAWLDSITCLLSELPQLSLPSGQQIARPPGTFLLMEVADTTGISPTVVGCCALVWCGGEQTWQCILSALMASLPYEYRLQHRTVAELNHMAEVLVPATLRFLTCQGVSSLLQVHGQQAVCAGVAEVTSMARILHSLLDLHLRLKEEKAPGPEDLSYSDPVAQSFRSSKSSFLNRSQVDSDDVPDKCREHLLAVSSFLFALIWGFGAHLPSRFWPIFDTFIRDSISRLSNYPEPPPSALVFDLHVSPEDGTLVPFTGQYLSSHIKGTLGTFHPSIQTERLLYVVDLLLSGGQPVLLAGEAATGKSAFVEVLVEPHHPYIYSPIHPAFSSSHLRLLLSRGIQGQTQASPQPGHHQDSKPSLLFLLEDLHLATSDPEKSCQPVLETLRQAMDGTVYAHSTLELQTLQPTVNFLATVTVPGYCERPLCPRLFRLFTVLALESMTQATLLERHVPIIQAWLERFPSVERERALARGLVRASVEAWEAVCNCFMPSPLHPHYHFSLHSVSHLLSSLQLLPNRTGSRGFVDYPNHQEHLRRVSGLRGTCLTVMMATRNVVRLWLHEAQRTFCDRLDSPRERSYCAKLLLVVAQSVFCCGPGPQHLGKDHQESEEEEEEERVPEVESEGELAQWEDFSNSNSETEEEEEPYGLQVARVSNSRDPSLTPSIGPVSRGMKESISHKIRQEKGTRASNYRLQVRRSFKTWWQKKPQMDLISPLLLPVLLLHPQEKPSDLVFSQELILGPNSETPNLYLERQWEKLEEQLATSAAQLKLSPHLARCHSMAQHVARLVRVLARPRQHGLLLSGALGTGRHTAITLASSICQAHFFHLPSGSEEAILQCLRDASWHAGMLSQPVALLVPSGVDLTTLHRLLALATSGSFPGQYTEADLDRIGEHLPRENLGVKQNIKKEMVLQRFHQQVCSHLHLFFLIGDKQAHKQLPSTLFLRLLQLATASIDRYEPWDQAALAKVAQHHLEGAQSVPLDDGSWKYPDLQASIPSVAKAMALIHLSATHYHEHLCPALPLVTPKTFLDFLDTFLMLQQQTILKIKNKAQRVQNALENLRMLIKEHGTHANLIFDLEQQLKDSGKSLSMFQQQLEQSKLLYKQQLEECRHQENLIENLARQRDALQAQREAFLEQMSKAFLEPLSQLQVADFEEIRSYRAPPESVVRVTDAMCDLFHHETGWASAKQLLCTEDFYQELVFFPKEKITDSELIKLHLILKAPGMDDAALRAVSRPAASLAAWLWAVLHYGLAHCRGLPTDLLLQQVEATLTREQARLGYYQFQAQETLEHNLALAKMVEDAQASHNCVAKTLSQAQCGQYHKWPMKAALLTPMRAWTTQLQKLKGRCMTVFGDTLLCSAAIIYLGPFPPLRRQELLDEWLALCRGFQEALGPDDVAQALKRKQKSVSIPPKNPLLATHSPFSILSLLSSESEQYQWDGNLKPQAKSAHLAGLLLRSPTHYSSCRWPLLLDPSNEALIWLDPLPLEENRSFAPALTEGRGKGLMRNQKRESKTDMKEEDDESEESNEAEDQTKEQKAEERKNEQEKEQEENEEKEEEKTESQGSKPAYETQLPSLPYLSVLSGADPELGSQLQEAAACGLPVLLTNVELGLGCEELQWLLQREQLSPPQVQPGFCLYLSTTLSLCAMEKVLGCELLKGLNVLDLGLNMEILEEQMLHEILCREYPELETRWQDLKIRALDTCKAVEAAEERLLTMLLFQNPKRQKPAKFLRNIVRAQGKLCQLRAHCEELEGQKLQEMVLWAPYRPVVWHGMAMVKALSQLQNLLPLFCMSPENWLAVTKQALDSMKPREINHGEDLASHLLQLRAHLTRQLLGSTVTALGLTQVPLVGALGALALLQATGKASELERLALWPGLAASPSTVHSKPVSDVARPAWLGPKAWHECEMLELLPPFVGLCASLAGHSSAWQAYLSLSSTVLGPAPGPGPEPLSLLQKLILWRVLRPECLAGALADFTTSLLGRPLDENTYAPTMPFKHSQATQPMLILLPPPGHPSATLHPLTVIQKLAAKYQQGQKQLQVIALGSEAWDPVSVVVSTLSQAMYEGHWLVLDNCHLMPHWPKELLQLLLELLGRAKVVADLESEQLLDQPESRNVSTVHRDFRLWLIVPAESSASLPAVLTQHSMPVFWNQSLELGHVLIDSVELAQQVLYMQPPTQALPLLLLHGLLLHRQLYGTRLQAHRGRWSQVTLTQVLQTQDQLWASLSNPRAAMQELAASVFYGGPLGDTEDREALISLTQACLSPSSGSWVQPHTPQSLLATLMPLPELRELDAMAECKAQMHLLPSPPEPRLCGLSEGPQAWLLRRQSRALLSALQRSSPVWVPESRRGAQLAERRLRQRLVQVNRRLESLQDLLTHVIRQDESDAPWSVLGPNARRPLEGVLETEALELSQLVGTLQRDLDCLLQQLKGAPPCPSRRCAAVAHALWTGRLPLPWRPHAPAGPQPPWHWLRQLSRRGQLLVRYLGVGADASSDVPERVFHLSAFRHPRRLLLALRGEAALDQNVPSSNFPGSRGSVSSQLQYKRLEMNSNPLHFRVENGPNPTVPERGLLLIGLQVLHAEWDPIAGALQDSPSSQPSPLPPVSISTQAPGTSDLPAPADLTVYSCPVYMGGPLGTAKLQSRNIVMHLPLPTKLTPNTCVQRRVHVCSPPLS"},{"id":"SEQ_04961","a":"Q9UJF2","g":"RASAL2","d":"Ras GTPase-activating protein nGAP","L":1139,"m":[{"c":"o[ST]o[SM]EDF","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three closely clustered 7-aa motifs in the central disordered region (positions 815-844, separated by 6- and 3-aa linkers) sharing an invariant acidic-aromatic EDF core preceded by a conserved polar o[ST]o[SM] segment.","i":[[815,821,"QSNSEDF"],[828,834,"NSSMEDF"],[838,844,"STQSEDF"]]}],"s":"MQTPEVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC"},{"id":"SEQ_04965","a":"Q99457","g":"NAP1L3","d":"Nucleosome assembly protein 1-like 3","L":506,"m":[{"c":"ExPKExP[EQ]VK[AD]--K","u":14,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four highly conserved 14-aa proline/charged repeats in the central disordered linker (positions 194-263), with three head-to-tail tandem copies followed in 14-aa phase by a fourth copy after a degenerate 14-aa segment ending in PEVK; anchored by eight invariant positions (E1, P3, K4, E5, P7, V9, K10, K14) and conserved acidic/polar positions.","i":[[194,207,"ENPKENPEVKAEEK"],[208,221,"EVPKEIPEVKDEEK"],[222,235,"EVPKEIPEVKAEEK"],[250,263,"EDPKEVPQVKADDK"]]}],"s":"MAEADFKMVSEPVAHGVAEEEMASSTSDSGEESDSSSSSSSTSDSSSSSSTSGSSSGSGSSSSSSGSTSSRSRLYRKKRVPEPSRRARRAPLGTNFVDRLPQAVRNRVQALRNIQDECDKVDTLFLKAIHDLERKYAELNKPLYDRRFQIINAEYEPTEEECEWNSEDEEFSSDEEVQDNTPSEMPPLEGEEEENPKENPEVKAEEKEVPKEIPEVKDEEKEVPKEIPEVKAEEKADSKDCMEATPEVKEDPKEVPQVKADDKEQPKATEAKARAAVRETHKRVPEERLQDSVDLKRARKGKPKREDPKGIPDYWLIVLKNVDKLGPMIQKYDEPILKFLSDVSLKFSKPGQPVSYTFEFHFLPNPYFRNEVLVKTYIIKAKPDHNDPFFSWGWEIEDCKGCKIDWRRGKDVTVTTTQSRTTATGEIEIQPRVVPNASFFNFFSPPEIPMIGKLEPREDAILDEDFEIGQILHDNVILKSIYYYTGEVNGTYYQFGKHYGNKKYRK"},{"id":"SEQ_04967","a":"Q86XN7","g":"PROSER1","d":"Proline and serine-rich protein 1","L":944,"m":[{"c":"V[LV][DN]x[IL][RN]x[AF]xφ[AST][EK]x[KQ]L[KV]Aψ[EK]φ[LV]xxxφ","u":25,"sp":"dispersed","x":"structured_like","cf":"high","why":"Three N-terminal 25-aa amphipathic helix-turn-helix repeats separated by short 4- and 7-aa linkers, anchored by invariant V1, L15, and A17 alongside conserved hydrophobic core positions (ψ/φ at positions 2, 5, 8, 10, 18, 20, 21, and 25).","i":[[9,33,"VLDEIRKAVLTEYKLKAIEYVHGYF"],[38,62,"VVDLLRYFSWAEPQLKAMKALQHKM"],[70,94,"VVNILNCFTFSKDKLVALELLASNI"]]},{"c":"S[IV]F[SAP]GL","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Dispersed 6-aa motif in the long P/S/T-rich C-terminal disordered region anchored by invariant S1, aromatic F3, G5, and L6 with constrained aliphatic [IV]2 and [SAP]4; copies 1 and 3 extend further into a 13-aa S[IV]F[SP]GL[VL]SLPG[PI][SP] match.","i":[[360,365,"SIFSGL"],[427,432,"SVFAGL"],[865,870,"SVFPGL"]]}],"s":"MDKKSFEMVLDEIRKAVLTEYKLKAIEYVHGYFSSEQVVDLLRYFSWAEPQLKAMKALQHKMVAVQPTEVVNILNCFTFSKDKLVALELLASNIIDAQNSRPIEDLFRVNMSEKKRCKRILEQAFKGGCKAPHAMISSCGTIPGNPYPKGRPSRINGIFPGTPLKKDGEECTNEGKGIAARILGPSKPPPSTYNPHKPVPYPIPPCRPHATIAPSAYNNAGLVPLANVIAPPPPPYTPNPVGTENEDLSNPSKPIQNQTFSTPASQLFSPHGSNPSTPAATPVPTASPVKAINHPSASAAATVSGMNLLNTVLPVFPGQVSSAVHTPQPSIPNPTVIRTPSLPTAPVTSIHSTTTTPVPSIFSGLVSLPGPSATPTAATPTPGPTPRSTLGSSEAFASTSAPFTSLPFSTSSSAASTSNPNSASLSSVFAGLPLPLPPTSQGLSNPTPVIAGGSTPSVAGPLGVNSPLLSALKGFLTSNDTNLINSSALSSAVTSGLASLSSLTLQNSDSSASAPNKCYAPSAIPTPQRTSTPGLALFPGLPSPVANSTSTPLTLPVQSPLATAASASTSVPVSCGSSASLLRGPHPGTSDLHISSTPAATTLPVMIKTEPTSPTPSAFKGPSHSGNPSHGTLGLSGTLGRAYTSTSVPISLSACLNPALSGLSSLSTPLNGSNPLSSISLPPHGSSTPIAPVFTALPSFTSLTNNFPLTGNPSLNPSVSLPGSLIATSSTAATSTSLPHPSSTAAVLSGLSASAPVSAAPFPLNLSTAVPSLFSVTQGPLSSSNPSYPGFSVSNTPSVTPALPSFPGLQAPSTVAAVTPLPVAATAPSPAPVLPGFASAFSSNFNSALVAQAGLSSGLQAAGSSVFPGLLSLPGIPGFPQNPSQSSLQELQHNAAAQSALLQQVHSASALESYPAQPDGFPSYPSAPGTPFSLQPSLSQSGWQ"},{"id":"SEQ_04968","a":"Q9BV73","g":"CEP250","d":"Centrosome-associated protein CEP250","L":2442,"m":[{"c":"xψxxx[LV]xx+xxxψxxQxxQ[IV]x-L[EQ](x){0,7}xxL[EQT]","u":"28-35","sp":"tandem","x":"structured_like","cf":"high","why":"Nine-copy 28-35 aa helical repeat array (copies 1-8 strictly head-to-tail contiguous from 1425-1682, followed by a 9th copy at 1726-1760) anchored by a 24-aa core with conserved aliphatic positions, basic residue at +9, Q anchors at +16/+19, and a signature Q[IV]x-L[EQ] motif followed by a 0-, 3-, or 7-aa variable helical turn and xxL[EQT] cap.","i":[[1425,1459,"LLTQTLAEREEEVETLRGQIQELEKQREMQKAALE"],[1460,1490,"LLSLDLKKRNQEVDLQQEQIQELEKCRSVLE"],[1491,1525,"HLPMAVQEREQKLTVQREQIRELEKDRETQRNVLE"],[1526,1556,"HQLLELEKKDQMIESQRGQVQDLKKQLVTLE"],[1557,1591,"CLALELEENHHKMECQQKLIKELEGQRETQRVALT"],[1592,1619,"HLTLDLEERSQELQAQSSQIHDLESHST"],[1620,1647,"VLARELQERDQEVKSQREQIEELQRQKE"],[1648,1682,"HLTQDLERRDQELMLQKERIQVLEDQRTRQTKILE"],[1726,1760,"HMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQ"]]},{"c":"LQxoφx[EQ]AQx[AV]Lx[EQ]RDQELEALxxEoQoxxxQEEx[AV]+x+A-ALQxALxxAHφxL","u":54,"sp":"dispersed","x":"structured_like","cf":"medium","why":"Long 54-aa ungapped internal duplication within the C-terminal coiled-coil region (residues 1801-1854 and 1924-1977, 48% exact identity) sharing conserved LQ, AQxxL, invariant RDQELEAL, QEE, A-ALQxAL, and AHφxL blocks far exceeding background heptad similarity.","i":[[1801,1854,"LQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTL"],[1924,1977,"LQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAAL"]]}],"s":"METRSPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSLTSPGPVLLHPSPSTTQAASR"},{"id":"SEQ_04977","a":"P55808","g":"XG","d":"Glycoprotein Xg","L":180,"m":[{"c":"φ[YP]P+P+P[PR][YP]","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 9-aa copies in the central disordered region share an N-terminal hydrophobic/tyrosine anchor followed by an invariant alternating proline-basic P+P+P core (linkers of 12 and 23 aa).","i":[[44,52,"IYPKPKPPY"],[65,73,"IYPRPKPRP"],[97,105,"YPPRPRPRP"]]}],"s":"MESWWGLPCLAFLCFLMHARGQRDFDLADALDDPEPTKKPNSDIYPKPKPPYYPQPENPDSGGNIYPRPKPRPQPQPGNSGNSGGYFNDVDRDDGRYPPRPRPRPPAGGGGGGYSSYGNSDNTHGGDHHSTYGNPEGNMVAKIVSPIVSVVVVTLLGAAASYFKLNNRRNCFRTHEPENV"},{"id":"SEQ_04979","a":"Q86YR5","g":"GPSM1","d":"G protein-signaling modulator 1","L":675,"m":[{"c":"Ax[EVT][FYC]xxxxLx[LI][AVS][RKQ][EQT]x[GAR]D[RKQ]x[GAV][EQ]xxAxx[NS]ψ[GA][NQ]xxxx[LMK][GQ]xx","u":38,"sp":"tandem","x":"structured_like","cf":"high","why":"Seven 38-aa alpha-solenoid-like repeats in the N-terminal structured domain anchored by invariant A(1), L(9), [LI](11), D(17), [EQ](21), A(24), and a conserved [NS]ψ[GA][NQ]...[GQ] signature, arranged with 2-aa turns except for a single 25-aa internal loop between copies 2 and 3.","i":[[85,122,"ALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRF"],[125,162,"AAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQ"],[188,225,"ASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNF"],[228,265,"ATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRF"],[268,305,"AAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDY"],[308,345,"AAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRP"],[348,385,"ALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLGRL"]]},{"c":"-[DEC]FF[DNS][LM][LI]x[KRS]xQ[SA][SRK]RψD-QR","u":19,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four strongly conserved 19-aa dispersed repeats in the C-terminal disordered tail (linkers of 35, 29, and 15 aa) anchored by an acidic-di-phenylalanine N-terminal motif (-[DEC]FF), invariant Q(11), and a C-terminal RψD-QR signature.","i":[[496,514,"ECFFDLLTKFQSSRMDDQR"],[549,567,"EEFFDLIASSQSRRLDDQR"],[597,615,"DDFFNMLIKYQSSRIDDQR"],[631,649,"EDFFSLIQRVQAKRMDEQR"]]}],"s":"MAGPAPPVADELPGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLEREQNGDSHHSGDWRGPSRDSLPLPVRSRKYQEGPDAERRPREGSHSPLDSADVRVHVPRTSIPRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTLEDRIAQPSMTASPQTEEFFDLIASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGHGEPQEPGDDFFNMLIKYQSSRIDDQRCPPPDVLPRGPTMPDEDFFSLIQRVQAKRMDEQRVDLAGGPEQGAGGPPEPQQQCQPGAS"},{"id":"SEQ_04995","a":"Q7LDI9","g":"ERVK-6","d":"Endogenous retrovirus group K member 6 Gag polyprotein","L":666,"m":[{"c":"CxxCxxxxHφxxoC","u":14,"sp":"dispersed","x":"structured_like","cf":"high","why":"Duplicated 14-residue Cys/His motif with strictly invariant C-x2-C-x4-H-x4-C spacing, a conserved hydrophobic residue immediately following H (L/W), and a polar amide preceding the final C (N/Q), separated by a 23-aa linker.","i":[[546,559,"CYNCGQIGHLKKNC"],[582,595,"CPRCKKGKHWASQC"]]},{"c":"PPx[AE]xQY","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three consecutive tandem 7-mer copies separated by 1-aa linkers (W, R) in the central proline-rich disordered region, anchored by invariant N-terminal PP and C-terminal QY positions plus [AE] at position 4.","i":[[206,212,"PPVAYQY"],[214,220,"PPAELQY"],[222,228,"PPPESQY"]]}],"s":"MGQTKSKIKSKYASYLSFIKILLKRGGVKVSTKNLIKLFQIIEQFCPWFPEQGTLDLKDWKRIGKELKQAGRKGNIIPLTVWNDWAIIKAALEPFQTEEDSVSVSDAPGSCIIDCNENTRKKSQKETEGLHCEYVAEPVMAQSTQNVDYNQLQEVIYPETLKLEGKGPELVGPSESKPRGTSPLPAGQVPVTLQPQKQVKENKTQPPVAYQYWPPAELQYRPPPESQYGYPGMPPAPQGRAPYPQPPTRRLNPTAPPSRQGSKLHEIIDKSRKEGDTEAWQFPVTLEPMPPGEGAQEGEPPTVEARYKSFSIKKLKDMKEGVKQYGPNSPYMRTLLDSIAHGHRLIPYDWEILAKSSLSPSQFLQFKTWWIDGVQEQVRRNRAANPPVNIDADQLLGIGQNWSTISQQALMQNEAIEQVRAICLRAWEKIQDPGSTCPSFNTVRQGSKEPYPDFVARLQDVAQKSIADEKARKVIVELMAYENANPECQSAIKPLKGKVPAGSDVISEYVKACDGIGGAMHKAMLMAQAITGVVLGGQVRTFGRKCYNCGQIGHLKKNCPVLNKQNITIQATTTGREPPDLCPRCKKGKHWASQCRSKFDKNGQPLSGNEQRGQPQAPQQTGAFPIQPFVPQGFQGQQPPLSQVFQGISQLPQYNNCPPPQAAVQQ"},{"id":"SEQ_05007","a":"Q6ZNL6","g":"FGD5","d":"FYVE, RhoGEF and PH domain-containing protein 5","L":1462,"m":[{"c":"Ax[TN]SDYENI[PQ]","u":10,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Head-to-tail tandem 10-residue duplication in the central disordered region sharing 7 identical anchor residues (A and the SDYENI core) plus conserved polar positions ([TN] and [PQ]); assigned medium confidence as a 2-copy repeat shorter than 15 aa.","i":[[769,778,"ADTSDYENIP"],[779,788,"AMNSDYENIQ"]]}],"s":"MFRGPKPPIAPKPRLTAPNEWRASVYLNDSLNKCSNGRLPCVDRGLDEGPRSIPKCSESETDEDYIVVPRVPLREDEPKDEGSVGNKALVSPESSAEEEEEREEGGEACGLEGTGAGEDSVAPAAPGAGALSREGEEGTDLALEDEGEGCADEPGTLEQVSRSEEEEKLVQPHRECSLEDSGPWAGEGVFQSDLLLPHIHGEDQEPPDTPGEAEEDDEEGCASTDPAGADEGSGPDRPTEDMGQDAEDTSEEPPEKEELAGVQEAETATDCPEVLEEGCEEATGVTGGEQVDLSEPPDHEKKTNQEVAAATLEDHAQDESAEESCQIVPFENDCMEDFVTSLTGSPYEFFPTESTSFCSESCSPLSESAKGLESEQAPKLGLRAEENPMVGALCGQCGSLQGGAAEGPAAPDVVVVLEEEALDDALANPYVMGVGLPGQAAPGEGGQAASDALGGYGSKEELNCEAEGGLVPADRKNTSTRVRPHSGKVAGYVPETVPEETGPEAGSSAPGIGGAAEEVGKTLLSLEGKPLEASRALPAKPRAFTLYPRSFSVEGREIPVSVYQEPEGSGLDDHRIKRKEDNLSLSCVIGSSGSFSQRNHLPSSGTSTPSSMVDIPPPFDLACITKKPITKSSPSLLIESDSPDKYKKKKSSFKRFLALTFKKKTENKLHVDVNVSSSRSSSESSYHGPSRILEVDRRSLSNSPQLKSRTGKLRASESPSSLIFYRDGKRKGVPFSRTVSRVESFEDRSRPPFLPLPLTKPRSISFPSADTSDYENIPAMNSDYENIQIPPRRPARAGAFTKLFEDQSRALSTANENDGYVDMSSFNAFESKQQSADQDAESAYTEPYKVCPISSAAPKEDLTSDEEQRSSEEEDSASRDPSVTHKVEGQSRALVIAQELLSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQGLSELPAIHDLHQGILEELEERLSNWESQQKVADVFLAREQGFDHHATHILQFDRYLGLLSENCLHSPRLAAAVREFEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLISKVTDRANDSMEQGENLQKLVHIEHSVRGQGDLLQPGREFLKEGTLMKVTGKNRRPRHLFLMNDVLLYTYPQKDGKYRLKNTLAVANMKVSRPVMEKVPYALKIETSESCLMLSASSCAERDEWYGCLSRALPEDYKAQALAAFHHSVEIRERLGVSLGERPPTLVPVTHVMMCMNCGCDFSLTLRRHHCHACGKIVCRNCSRNKYPLKYLKDRMAKVCDGCFGELKKRGRAVPGLMRERPVSMSFPLSSPRFSGSAFSSVFQSINPSTFKKQKKVPSALTEVAASGEGSAISGYLSRCKRGKRHWKKLWFVIKGKVLYTYMASEDKVALESMPLLGFTIAPEKEEGSSEVGPIFHLYHKKTLFYSFKAEDTNSAQRWIEAMEDASVL"},{"id":"SEQ_05013","a":"Q8IY37","g":"DHX37","d":"Probable ATP-dependent RNA helicase DHX37","L":1157,"m":[{"c":"[PI]L[STE][KQ]KEKK","u":8,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three 8-residue repeats in the basic N-terminal disordered region (two head-to-tail copies followed by a third copy after a 4-aa linker) anchored by fixed L2 and a C-terminal KEKK module with conserved [PI]1, [STE]3, and [KQ]4 positions.","i":[[63,70,"PLSKKEKK"],[71,78,"PLTKKEKK"],[83,90,"ILEQKEKK"]]}],"s":"MGKLRRRYNIKGRQQAGPGPSKGPPEPPPVQLELEDKDTLKGVDASNALVLPGKKKKKTKAPPLSKKEKKPLTKKEKKVLQKILEQKEKKSQRAEMLQKLSEVQASEAEMRLFYTTSKLGTGNRMYHTKEKADEVVAPGQEKISSLSGAHRKRRRWPSAEEEEEEEEESESELEEESELDEDPAAEPAEAGVGTTVAPLPPAPAPSSQPVPAGMTVPPPPAAAPPLPRALAKPAVFIPVNRSPEMQEERLKLPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIGVTEPRRVAAVAMSQRVAKEMNLSQRVVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKRNLPLKLLIMSATLRVEDFTQNPRLFAKPPPVIKVESRQFPVTVHFNKRTPLEDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCRRLRKAFPPSRARPQEKDDDQKDSVEEMRKFKKSRARAKKARAEVLPQINLDHYSVLPAGEGDEDREAEVDEEEGALDSDLDLDLGDGGQDGGEQPDASLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRRPVEDLILQMKALNVEKVINFPFPTPPSVEALLAAEELLIALGALQPPQKAERVKQLQENRLSCPITALGRTMATFPVAPRYAKMLALSRQHGCLPYAITIVASMTVRELFEELDRPAASDEELTRLKSKRARVAQMKRTWAGQGASLKLGDLMVLLGAVGACEYASCTPQFCEANGLRYKAMMEIRRLRGQLTTAVNAVCPEAELFVDPKMQPPTESQVTYLRQIVTAGLGDHLARRVQSEEMLEDKWRNAYKTPLLDDPVFIHPSSVLFKELPEFVVYQEIVETTKMYMKGVSSVEVQWIPALLPSYCQFDKPLEEPAPTYCPERGRVLCHRASVFYRVGWPLPAIEVDFPEGIDRYKHFARFLLEGQVFRKLASYRSCLLSSPGTMLKTWARLQPRTESLLRALVAEKADCHEALLAAWKKNPKYLLAEYCEWLPQAMHPDIEKAWPPTTVH"},{"id":"SEQ_05026","a":"O15156","g":"ZBTB7B","d":"Zinc finger and BTB domain-containing protein 7B","L":539,"m":[{"c":"CxxC[HGP]xx[FI]xxxxxLxxH[ML][KRH](x){1,3}[HC]","u":"21-23","sp":"periodic","x":"structured_like","cf":"high","why":"Four periodic 21-23 aa repeats separated by conserved 7-aa TG[ED][KR]P[FY]x linkers, defined by invariant CxxC N-terminal anchors, conserved core hydrophobics ([FI] and L), and H[ML][KRH](x){1,3}[HC] C-terminal anchors.","i":[[348,368,"CPVCHKIIHGAGKLPRHMRTH"],[376,396,"CEVCGVRFTRNDKLKIHMRKH"],[404,424,"CPHCPARFLHSYDLKNHMHLH"],[432,454,"CHLCHKAFAKEDHLQRHLKGQNC"]]}],"s":"MGSPEDDLIGIPFPDHSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEGGGGAVMGAGGSGTATGGAGAGVCELDFVGPEALGALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEILQGSGLEAPSPDEDDCERARQYLEAFATATASGVPNGEDSPPQVPLPPPPPPPPRPVARRSRKPRKAFLQTKGARANHLVPEVPTVPAHPLTYEEEEVAGRVGSSGGSGPGDSYSPPTGTASPPEGPQSYEPYEGEEEEEELVYPPAYGLAQGGGPPLSPEELGSDEDAIDPDLMAYLSSLHQDNLAPGLDSQDKLVRKRRSQMPQECPVCHKIIHGAGKLPRHMRTHTGEKPFACEVCGVRFTRNDKLKIHMRKHTGERPYSCPHCPARFLHSYDLKNHMHLHTGDRPYECHLCHKAFAKEDHLQRHLKGQNCLEVRTRRRRKDDAPPHYPPPSTAAASPAGLDLSNGHLDTFRLSLARFWEQSAPTGPPVSTPGPPDDDEEEGAPTTPQAEGAMESS"},{"id":"SEQ_05034","a":"P35498","g":"SCN1A","d":"Sodium channel protein type 1 subunit alpha","L":2009,"m":[{"c":"[FV]xψxψxxxxxx[NA]xφ[FT][ME]xψ(x){12,18}[TV]F[TI]xψΩ[TI]xExφψKφψ(x){10,15}W[NC][WI][LF]D[FG]x[VI][VI]xφ[AS]φVxxxφ(x){8,17}RxφRφ[LG]Rx[LF]+xφ[SK]xφx[GT]ψxxψψx[AI][LI]xx[SA]ψxx[LI]x[ND]ψx[LI][LV]xφφxφxφ[FA]xφxGψo[LN]F(x){54,128}xxφxφF[VM]xφ[IM]φφ[GS]x[FL]φxψN[LM]φ[LI][AG][VL]ψφxxΩ","u":"226-297","sp":"dispersed","x":"structured_like","cf":"high","why":"Four large internal domain duplications each spanning six conserved hydrophobic/transmembrane segments with invariant anchors (F, E, K in segment 2; W and D in segment 3; periodic RxxRxxR+ motif and Gψo[LN]F in segments 4-5; F and N in segment 6) separated by variable loops and long cytoplasmic linkers.","i":[[130,426,"FSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAY"],[770,995,"VDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSF"],[1223,1486,"FIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNF"],[1543,1789,"FDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF"]]},{"c":"RxSLF[SV][PF]R","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three copies of a conserved 8-residue motif within the polar/charged disordered linker between the first two structured repeats, anchored by invariant flanking R residues and a fixed central SLF core followed by [SV][PF].","i":[[560,567,"RGSLFSPR"],[571,578,"RTSLFSFR"],[605,612,"RDSLFVPR"]]}],"s":"MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGSTVDIGAPVEEQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPPSYDRVTKPIVEKHEQEGKDEKAKGK"},{"id":"SEQ_05046","a":"P02812","g":"PRB2","d":"Basic salivary proline-rich protein 2","L":416,"m":[{"c":"GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQG[DG](x){0,1}KS[RQ]S[PSA]RSPP","u":"61-62","sp":"tandem","x":"disordered_like","cf":"high","why":"Five head-to-tail tandem copies of a highly conserved 61-62 aa proline/glycine/glutamine-rich disordered cassette (51 invariant N-terminal residues followed by a conserved [DG](x){0,1}KS[RQ]S[PSA]RSPP motif), built from three ~20-21 aa GKPQGPPPQG sub-repeats with additional diverged sub-units flanking the array.","i":[[55,115,"GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPP"],[116,177,"GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPP"],[178,239,"GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPP"],[240,301,"GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPP"],[302,363,"GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPP"]]}],"s":"MLLILLSVALLALSSAQNLNEDVSQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRPPQ"},{"id":"SEQ_05054","a":"O60840","g":"CACNA1F","d":"Voltage-dependent L-type calcium channel subunit alpha-1F","L":1977,"m":[{"c":"Ωxxψψφψxφφxox[VT][AIS][LA](x){22,26}xψFT[VI]ExψLKψx(x){11,15}[WF]Nx[LF]Dxφ[IV]V(x){20,34}RxφRψψR[PIL]φ+φxxxxx[SG]ψxxψψxxφφx[AS]φxxψxxψφψψxxφφxφψΩ[AS]xψGψ[EQ][LM]F(x){14,52}[NT]F[DQ][NT]φxxAψψxψFxxxTxE[GDA]Wxxψ[LM]φ(x){14,30}FψxφφψxxxΩφψψNψφψ[GA]φφxxx[FL]","u":"230-282","sp":"dispersed","x":"structured_like","cf":"high","why":"Four large dispersed multi-segment hydrophobic domain duplications separated by 52-152 aa polar/charged linkers, each conserving six hydrophobic segments and invariant sequence anchors including FT[VI]ExψLK, [WF]Nx[LF]D, a periodic basic RxφRψψR[PIL]φ+ segment, Gψ[EQ][LM]F, FxxxTxE[GDA]W, and C-terminal Nψφψ[GA]φφ.","i":[[94,375,"FDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEF"],[532,761,"YWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNL"],[873,1140,"FTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITF"],[1192,1444,"FEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNF"]]}],"s":"MSESEGGKDTTPEPSPANGAGPGPEWGLCPGPPAVEGESSGASGLGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSMTETQGDEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTAKDKGGEKSNEKDLPQENEGLVPGVEKEEEEGARREGADMEEEEEEEEEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVTFNATLFALVRTSLKIKTEGNLEQANQELRIVIKKIWKRMKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAGLRSLQDLGPEMRQALTCDTEEEEEEGQEGVEEEDEKDLETNKATMVSQPSARRGSGISVSLPVGDRLPDSLSFGPSDDDRGTPTSSQPSVPQAGSNTHRRGSGALIFTIPEEGNSQPKGTKGQNKQDEDEEVPDRLSYLDEQAGTPPCSVLLPPHRAQRYMDGHLVPRRRLLPPTPAGRKPSFTIQCLQRQGSCEDLPIPGTYHRGRNSGPNRAQGSWATPPQRGRLLYAPLLLVEEGAAGEGYLGRSSGPLRTFTCLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRFVALAKQEIADACRLTLDEMDNAASDLLAQGTSSLYSDEESILSRFDEEDLGDEMACVHAL"},{"id":"SEQ_05057","a":"Q96N21","g":"TEPSIN","d":"AP-4 complex accessory subunit Tepsin","L":525,"m":[{"c":"SPφP[STA][PS][GP]x[PD][SA]","u":10,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Three head-to-tail 10-residue repeats in the C-terminal Pro/Ser-rich disordered region anchored by an invariant N-terminal SPφP core (with aliphatic A, V, I at position 3) and conserved C-terminal [GP]x[PD][SA] positions (7/10 exact identity between copies 1 and 3).","i":[[403,412,"SPAPSSGMPS"],[413,422,"SPVPTPPPDA"],[423,432,"SPIPAPGDPS"]]}],"s":"MAAAPPLRDRLSFLHRLPILLKGTSDDDVPCPGYLFEEIAKISHESPGSSQCLLEYLLSRLHSSSGHGKLKVLKILLYLCSHGSSFFLLILKRNSAFIQEAAAFAGPPDPLHGNSLYQKVRAAAQDLGSTLFSDTVLPLAPSQPLGTPPATGMGSQARPHSTLQGFGYSKEHGRTAVRHQPGQAGGGWDELDSGPSSQNSSQNSDLSRVSDSGSHSGSDSHSGASREPGDLAERVEVVALSDCQQELSLVRTVTRGPRAFLSREEAQHFIKACGLLNCEAVLQLLTCHLRGTSECTQLRALCAIASLGSSDLLPQEHILLRTRPWLQELSMGSPGPVTNKATKILRHFEASCGQLSPARGTSAEPGPTAALPGPSDLLTDAVPLPGSQVFLQPLSSTPVSSRSPAPSSGMPSSPVPTPPPDASPIPAPGDPSEAEARLAESRRWRPERIPGGTDSPKRGPSSCAWSRDSLFAGMELVACPRLVGAGAAAGESCPDAPRAPQTSSQRTAAKEPPGSEPSAFAFLNA"},{"id":"SEQ_05078","a":"Q9NXV6","g":"CDKN2AIP","d":"CDKN2A-interacting protein","L":580,"m":[{"c":"[SAP][KSQ]x[ST]Sxxxx[SP]x[LVS]","u":12,"sp":"tandem","x":"disordered_like","cf":"high","why":"Eleven tandem 12-aa repeats (separated by 0-1 aa linkers) in the central Ser/Thr-rich disordered region, anchored by conserved N-terminal [SAP][KSQ]x[ST]S and C-terminal [SP]x[LVS] (predominantly SLL/SQL/PLL) motifs.","i":[[282,293,"SQSSSEIEVPLL"],[295,306,"SSGSSEVELPLL"],[308,319,"SKPSSETASSGL"],[321,332,"SKTSSEASVSSS"],[334,345,"AKNSSSSGTSLL"],[347,358,"PKSSSSTNTSLL"],[360,371,"SKSTSQVAASLL"],[373,384,"SKSSSQTSGSLV"],[385,396,"SKSTSLASVSQL"],[398,409,"SKSSSQTSTSQL"],[411,422,"SKSTSQSSESSV"]]}],"s":"MAQEVSEYLSQNPRVAAWVEALRCDGETDKHWRHRRDFLLRNAGDLAPAGGAASASTDEAADAESGTRNRQLQQLISFSMAWANHVFLGCRYPQKVMDKILSMAEGIKVTDAPTYTTRDELVAKVKKRGISSSNEGVEEPSKKRVIEGKNSSAVEQDHAKTSAKTERASAQQENSSTCIGSAIKSESGNSARSSGISSQNSSTSDGDRSVSSQSSSSVSSQVTTAGSGKASEAEAPDKHGSASFVSLLKSSVNSHMTQSTDSRQQSGSPKKSALEGSSASASQSSSEIEVPLLGSSGSSEVELPLLSSKPSSETASSGLTSKTSSEASVSSSVAKNSSSSGTSLLTPKSSSSTNTSLLTSKSTSQVAASLLASKSSSQTSGSLVSKSTSLASVSQLASKSSSQTSTSQLPSKSTSQSSESSVKFSCKLTNEDVKQKQPFFNRLYKTVAWKLVAVGGFSPNVNHGELLNAAIEALKATLDVFFVPLKELADLPQNKSSQESIVCELRCKSVYLGTGCGKSKENAKAVASREALKLFLKKKVVVKICKRKYRGSEIEDLVLLDEESRPVNLPPALKHPQELL"},{"id":"SEQ_05081","a":"P0CJ92","g":"GOLGA8H","d":"Golgin subfamily A member 8H","L":632,"m":[{"c":"QEER[IL][QR][EK]","u":7,"sp":"tandem","x":"structured_like","cf":"medium","why":"Three contiguous 7-aa repeats embedded within the broader coiled-coil domain exhibiting sequence-level duplication far above generic heptad periodicity, with an invariant QEER core, conserved aliphatic [IL] at position 5, and identical first and third copies.","i":[[339,345,"QEERIQE"],[346,352,"QEERLRK"],[353,359,"QEERIQE"]]}],"s":"MAEETQHNKLAAAKKKLKEYWQKNSPRVPAGANRNRKTNGSVPEKATSGGCQPPGDSATGFHREGPTSSATLKDLESPCQERAVVLDSRSVEISQLKNTIKSLKQQKKQVEHQLEEEKKANNKKQKAKRVLEVQIQTLNIQKGKLNTDLYHMKRSLRYFEEKSKDLAVCLQHSLQRKGELESVLSNVMATQKKKANQLSSRSKARTEWKLEQSMREEALLKVQLTQLKESFQQVQLERDECAEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSLQQLAKPQSVFEEPNNENKNALQLEQQVKELQEKLGEEHLEAASQQNQQLTAQLSLMALPGEGHGGEHLDSEGEEAPRPMPSVPEDPESREAMSSFMDHLEEKADLSELVKKKELCFIHHWRDRCHQKTHHLLSEPGGRAKDAALGGGHHQAGAQGGDEGEAAGAAADGIAAYSNYNNGHRKFLAAAHNSADEPGPGAPAPQELGAADKHGDLCEVSLTSSAQGEAREDPLLDKPTAQPIVQDHQEHPGLGSNCCVPLLCWAWLPRRRR"},{"id":"SEQ_05083","a":"O75541","g":"ZNF821","d":"Zinc finger protein 821","L":412,"m":[{"c":"Rx[NQ]E[TP][PLD]ExRxxR[LM]xR-R[ET]A[KM]+[LS][KRQ]","u":23,"sp":"tandem","x":"mixed","cf":"high","why":"Four head-to-tail 23-aa repeats combining a conserved Rx[NQ]E[TP][PLD]E turn-like N-cap with a highly conserved Arg/Glu-rich helical core anchored by invariant R, E, and A positions and a C-terminal R-R[ET]A[KM]+[LS][KRQ] motif.","i":[[262,284,"RQNEPLEVRLQRLERERTAKKSR"],[285,307,"RDNETPEEREVRRMRDREAKRLQ"],[308,330,"RMQETDEQRARRLQRDREAMRLK"],[331,353,"RANETPEKRQARLIREREAKRLK"]]}],"s":"MSRRKQTNPNKVHWDQVFAGLEEQARQAMMKTDFPGDLGSQRQAIQQLRDQDSSSSDSEGDEEETTQDEVSSHTSEEDGGVVKVEKELENTEQPVGGNEVVEHEVTGNLNSDPLLELCQCPLCQLDCGSREQLIAHVYQHTAAVVSAKSYMCPVCGRALSSPGSLGRHLLIHSEDQRSNCAVCGARFTSHATFNSEKLPEVLNMESLPTVHNEGPSSAEGKDIAFSPPVYPAGILLVCNNCAAYRKLLEAQTPSVRKWALRRQNEPLEVRLQRLERERTAKKSRRDNETPEEREVRRMRDREAKRLQRMQETDEQRARRLQRDREAMRLKRANETPEKRQARLIREREAKRLKRRLEKMDMMLRAQFGQDPSAMAALAAEMNFFQLPVSGVELDSQLLGKMAFEEQNSSSLH"},{"id":"SEQ_05089","a":"O95171","g":"SCEL","d":"Sciellin","L":688,"m":[{"c":"[GR]x[QKE]xL-[NS]φψ+VxP","u":13,"sp":"periodic","x":"mixed","cf":"high","why":"17 periodic copies (typically separated by 7-aa polar/charged linkers for a regular 20-aa repeat period) anchored by an invariant L, conserved [QKE]xL-[NS] polar-acidic-polar face, hydrophobic/aliphatic core positions (φψ at 8-9, V at 11), basic K/R at 10, flanking N-terminal [GR], and C-terminal P cap.","i":[[231,243,"RSQDLDNIVKVAT"],[250,262,"KGEELDNLIKMNK"],[266,278,"RNQGLDSLFRANP"],[286,298,"RAKSLESLIYMST"],[306,318,"GIQSLGSPIKVNQ"],[326,338,"GRQNLESVAKVNA"],[346,358,"RSEDLDNATEVNP"],[366,378,"GKKDLDGLIKVDP"],[386,398,"RGQSLDNLIKVTP"],[406,418,"GSKDLNNFIKVYP"],[426,438,"GGQSLDSLIKVTP"],[446,458,"GNQDLENLIKVIP"],[464,476,"SEQGLDEHINVSP"],[484,496,"GKQDLDKLIKVNP"],[504,516,"RNQDLANLIKVNP"],[523,535,"QSQDLDNLIKVKP"],[543,555,"RDQNLENLIEVNS"]]}],"s":"MSNVTLRKMSPTGNEMKSTTQGTTRKQQDFHEVNKRRTFLQDNSWIKKRPEEEKDENYGRVVLNRHNSHDALDRKVNERDVPKATISRYSSDDTLDRISDRNDAAKTYKANTLDNQLTNRSMSMFRSLEVTKLQPGGSLNANTSNTIASTSATTPVKKKRQSWFPPPPPGYNASSSTGTRRREPGVHPPIPPKPSSPVSSPNQLRQDNRQIHPPKPGVYTETNRSAERNIRSQDLDNIVKVATSLQRSDKGEELDNLIKMNKSLNRNQGLDSLFRANPKVEEREKRAKSLESLIYMSTRTDKDGKGIQSLGSPIKVNQRTDKNEKGRQNLESVAKVNARMNKTSRRSEDLDNATEVNPKGHENTTGKKDLDGLIKVDPETNKNITRGQSLDNLIKVTPEVKRSNQGSKDLNNFIKVYPGTEKSTEGGQSLDSLIKVTPERNRTNQGNQDLENLIKVIPSANKSSEQGLDEHINVSPKAVKNTDGKQDLDKLIKVNPEIFTNNQRNQDLANLIKVNPAVIRNNQSQDLDNLIKVKPSALRNTNRDQNLENLIEVNSHVSENKNGSSNTGAKQAGPQDTVVYTRTYVENSKSPKDGYQENISGKYIQTVYSTSDRSVIERDMCTYCRKPLGVETKMILDELQICCHSTCFKCEICKQPLENLQAGDSIWIYRQTIHCEPCYSKIMAKWIP"},{"id":"SEQ_05094","a":"Q8IZL8","g":"PELP1","d":"Proline-, glutamic acid- and leucine-rich protein 1","L":1130,"m":[{"c":"G[PS][MV]PS[AV]","u":6,"sp":"tandem","x":"disordered_like","cf":"high","why":"Five head-to-tail tandem hexapeptide repeats (residues 669-698) within the proline-rich disordered region, anchored by invariant G1, P4, and S5 positions and tightly constrained [PS]2, [MV]3, and [AV]6 substitutions.","i":[[669,674,"GPMPSV"],[675,680,"GSMPSA"],[681,686,"GPMPSA"],[687,692,"GPMPSA"],[693,698,"GPVPSA"]]}],"s":"MAAAVLSGPSAGSAAGVPGGTGGLSAVSSGPRLRLLLLESVSGLLQPRTGSAVAPVHPPNRSAPHLPGLMCLLRLHGSVGGAQNLSALGALVSLSNARLSSIKTRFEGLCLLSLLVGESPTELFQQHCVSWLRSIQQVLQTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQSALEGMKACMTYFPRACGSLKGKLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETAPVQNEGPGVEMLLSSEDGDAHVLLQLRQRFSGLARCLGLMLSSEFGAPVSVPVQEILDFICRTLSVSSKNISLHGDGPLRLLLLPSIHLEALDLLSALILACGSRLLRFGILIGRLLPQVLNSWSIGRDSLSPGQERPYSTVRTKVYAILELWVQVCGASAGMLQGGASGEALLTHLLSDISPPADALKLRSPRGSPDGSLQTGKPSAPKKLKLDVGEAMAPPSHRKGDSNANSDVCAAALRGLSRTILMCGPLIKEETHRRLHDLVLPLVMGVQQGEVLGSSPYTSSRCRRELYCLLLALLLAPSPRCPPPLACALQAFSLGQREDSLEVSSFCSEALVTCAALTHPRVPPLQPMGPTCPTPAPVPPPEAPSPFRAPPFHPPGPMPSVGSMPSAGPMPSAGPMPSAGPVPSARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIPPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLADFIDCPPDDEKPPPPTEPDS"},{"id":"SEQ_05097","a":"P35579","g":"MYH9","d":"Myosin-9","L":1960,"m":[{"c":"φφxxxQ(x){3,6}[AR][GA][VY]L[AK]xxxxxxxxxx[TL]","u":"25-28","sp":"tandem","x":"structured_like","cf":"medium","why":"Three tandem helical repeats (1-residue gaps) immediately N-terminal to the long coiled-coil rod share an N-terminal φφxxxQ motif and a central [AR][GA][VY]L[AK] core, with a 3-residue insertion in the first copy. The C-terminal half of each unit is sequence-divergent, warranting medium confidence.","i":[[753,780,"LYRIGQSKVFFRAGVLAHLEEERDLKIT"],[782,806,"VIIGFQACCRGYLARKAFAKRQQQL"],[808,832,"AMKVLQRNCAAYLKLRNWQWWRLFT"]]}],"s":"MAQQAADKYLYVDKNFINNPLAQADWAAKKLVWVPSDKSGFEPASLKEEVGEEAIVELVENGKKVKVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSHKSKKDQGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLSGAGEHLKTDLLLEPYNKYRFLSNGHVTIPGQQDKDMFQETMEAMRIMGIPEEEQMGLLRVISGVLQLGNIVFKKERNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQTKEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPKATDKSFVEKVMQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVSELWKDVDRIIGLDQVAGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIPKGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEEVDGKADGAEAKPAE"},{"id":"SEQ_05098","a":"Q6NUP7","g":"PPP4R4","d":"Serine/threonine-protein phosphatase 4 regulatory subunit 4","L":873,"m":[{"c":"xx[IV]L(x){0,1}P[KLE][LV](x){18,21}[LF]xx[IL]xxxxxxxxxx","u":"39-42","sp":"dispersed","x":"structured_like","cf":"high","why":"Five 39-42 aa helical repeat units (one N-terminal copy followed by four head-to-tail tandem copies across residues 171-330) anchored by an N-terminal [IV]L and P[KLE][LV] turn motif and a second amphipathic helix bearing conserved [LF]xx[IL] hydrophobic core positions.","i":[[91,129,"RRVLPKVREALHVAGVEMQLTAAMSFLTILQDESVSIHA"],[171,210,"HEILNPLVSKAQLSQTVQSRLVSCKILGKLTNKFDAHTIK"],[211,249,"REILPLVKSLCQDVEYEVRSCMCRQLENIAQGIGTELTK"],[250,288,"SVVLPELIELSRDEGSSVRLAAFETLVNLLDIFDTDDRS"],[289,330,"QTILPLVKSFCEKSFKADESILISLSFHLGKLCHGLYGIFTP"]]}],"s":"MHPPPPAAAMDFSQNSLFGYMEDLQELTIIERPVRRSLKTPEEIERLTVDEDLSDIERAVYLLSAGQDVQGTSVIANLPFLMRQNPTETLRRVLPKVREALHVAGVEMQLTAAMSFLTILQDESVSIHAYTHSFLQVILLHLEHRDTGVSNAWLETLLSVIEVLPKETLRHEILNPLVSKAQLSQTVQSRLVSCKILGKLTNKFDAHTIKREILPLVKSLCQDVEYEVRSCMCRQLENIAQGIGTELTKSVVLPELIELSRDEGSSVRLAAFETLVNLLDIFDTDDRSQTILPLVKSFCEKSFKADESILISLSFHLGKLCHGLYGIFTPDQHLRFLEFYKKLCTLGLQQENGHNENQIPPQILEQEKKYISVRKNCAYNFPAMIVFVDPKNFHMELYSTFFCLCHDPEVPVRYTIAICFYEVSKLLNSGVYLIHKELITLLQDESLEVLDALIDHLPEILELMSTGGESSVQENKLSSLPDLIPALTAAEQRAAASLKWRTHEKLLQKYACLPHVISSDQIYYRFLQRMFTIMMTNNVLPVQKAASRTLCIFLRYNRKQEQRHEVIQKLIEQLGQGKSYWNRLRFLDTCEFIIEIFSKSFFCKYFFLPAIELTHDPVANVRMKLCYLLPKVKSTLKIPADKHLLQQLEMCVRKLLCQEKDKDVLAIVKRTVLELDRMEMSMDAFQKKFYEKDLLDQEKEREELLLLEMEQLEKEKQQNDGRPMSDKMFEKKRRDTKTPTQSLPKNIPISVPGPSSVTPSTSKEIKKSKLIRSQSFNNQAFHAKYGNLEKCASKSSTTGYTTSVSGLGKTSVLSLADDSFRTRNASSVPSSFSPNTPLPSTSRGTGNSVDPKSSGSKDTQPRKATLKSRKSNP"},{"id":"SEQ_05104","a":"Q9Y6Q6","g":"TNFRSF11A","d":"Tumor necrosis factor receptor superfamily member 11A","L":616,"m":[{"c":"C(x){3,5}Y(x){5,10}C(x){3,8}C(x){16,18}[VR]C","u":"35-42","sp":"tandem","x":"structured_like","cf":"high","why":"Four tandem 35-42 aa cysteine-rich repeats separated by 1-2 aa linkers in the N-terminal region, each anchored by four conserved cysteines, an invariant N-terminal hairpin tyrosine (Y), and a C-terminal [VR]C dyad.","i":[[34,68,"CTSEKHYEHLGRCCNKCEPGKYMSSKCTTTSDSVC"],[71,112,"CGPDEYLDSWNEEDKCLLHKVCDTGKALVAVVAGNSTTPRRC"],[114,151,"CTAGYHWSQDCECCRRNTECAPGLGAQHPLQLNKDTVC"],[154,194,"CLAGYFSDAFSSTDKCRPWTNCTFLGKRVEHHGTEKSDAVC"]]}],"s":"MAPRARRRRPLFALLLLCALLARLQVALQIAPPCTSEKHYEHLGRCCNKCEPGKYMSSKCTTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCRPWTNCTFLGKRVEHHGTEKSDAVCSSSLPARKPPNEPHVYLPGLIILLLFASVALVAAIIFGVCYRKKGKALTANLWHWINEACGRLSGDKESSGDSCVSTHTANFGQQGACEGVLLLTLEEKTFPEDMCYPDQGGVCQGTCVGGGPYAQGEDARMLSLVSKTEIEEDSFRQMPTEDEYMDRPSQPTDQLLFLTEPGSKSTPPFSEPLEVGENDSLSQCFTGTQSTVGSESCNCTEPLCRTDWTPMSSENYLQKEVDSGHCPHWAASPSPNWADVCTGCRNPPGEDCEPLVGSPKRGPLPQCAYGMGLPPEEEASRTEARDQPEDGADGRLPSSARAGAGSGSSPGGQSPASGNVTGNSNSTFISSGQVMNFKGDIIVVYVSQTSQEGAAAAAEPMGRPVQEETLARRDSFAGNGPRFPDPCGGPEGLREPEKASRPVQEQGGAKA"},{"id":"SEQ_05119","a":"Q9H9D4","g":"ZNF408","d":"Zinc finger protein 408","L":720,"m":[{"c":"xxCxxC[GDA]xx[FYL]xxxxx[LF]+xHxxxH(x){3,7}[PA]","u":"27-31","sp":"tandem","x":"structured_like","cf":"high","why":"Ten head-to-tail tandem 27-31 aa C2H2-type finger repeats defined by invariant CxxC and HxxxH coordination pairs, conserved [FYL] and [LF]+ core/helix positions, and a proline-terminated inter-unit linker.","i":[[353,380,"YRCGECGKAFLQLCHLKKHAFVHTGHKP"],[381,408,"FLCTECGKSYSSEESFKAHMLGHRGVRP"],[409,436,"FPCPQCDKAYGTQRDLKEHQVVHSGARP"],[437,467,"FACDQCGKAFARRPSLRLHRKTHQVPAAPAP"],[468,495,"CPCPVCGRPLANQGSLRNHMRLHTGEKP"],[496,523,"FLCPHCGRAFRQRGNLRGHLRLHTGERP"],[524,550,"YRCPHCADAFPQLPELRRHLISHTGEA"],[551,578,"HLCPVCGKALRDPHTLRAHERLHSGERP"],[579,606,"FPCPQCGRAYTLATKLRRHLKSHLEDKP"],[607,634,"YRCPTCGMGYTLPQSLRRHQLSHRPEAP"]]}],"s":"MEEAEELLLEGKKALQLAREPRLGLDLGWNPSGEGCTQGLKDVPPEPTRDILALKSLPRGLALGPSLAKEQRLGVWCVGDPLQPGLLWGPLEEESASKEKGEGVKPRQEENLSLGPWGDVCACEQSSGWTSLVQRGRLESEGNVAPVRISERLHLQVYQLVLPGSELLLWPQPSSEGPSLTQPGLDKEAAVAVVTEVESAVQQEVASPGEDAAEPCIDPGSQSPSGIQAENMVSPGLKFPTQDRISKDSQPLGPLLQDGDVDEECPAQAQMPPELQSNSATQQDPDGSGASFSSSARGTQPHGYLAKKLHSPSDQCPPRAKTPEPGAQQSGFPTLSRSPPGPAGSSPKQGRRYRCGECGKAFLQLCHLKKHAFVHTGHKPFLCTECGKSYSSEESFKAHMLGHRGVRPFPCPQCDKAYGTQRDLKEHQVVHSGARPFACDQCGKAFARRPSLRLHRKTHQVPAAPAPCPCPVCGRPLANQGSLRNHMRLHTGEKPFLCPHCGRAFRQRGNLRGHLRLHTGERPYRCPHCADAFPQLPELRRHLISHTGEAHLCPVCGKALRDPHTLRAHERLHSGERPFPCPQCGRAYTLATKLRRHLKSHLEDKPYRCPTCGMGYTLPQSLRRHQLSHRPEAPCSPPSVPSAASEPTVVLLQAEPQLLDTHREEEVSPARDVVEVTISESQEKCFVVPEEPDAAPSLVLIHKDMGLGAWAEVVEVEMGT"},{"id":"SEQ_05122","a":"Q8WXE0","g":"CASKIN2","d":"Caskin-2","L":1202,"m":[{"c":"xxx[PA]L[HD]xA[AC]xxGxx[EK]xxx[LM]LLxxxxxxxxxxx","u":32,"sp":"tandem","x":"structured_like","cf":"high","why":"Six 32-aa structured repeats arranged nearly head-to-tail (0-1 aa junctions except a 9-aa loop between copies 4 and 5), anchored by invariant L5, A8, G12, L20, L21 and constrained [PA]4, [HD]6, [AC]9, [EK]15, [LM]19 positions.","i":[[49,80,"GFSALHHAALGGSLELIALLLEAQATVDIKDS"],[82,113,"GMRPLHYAAWQGRLEPVRLLLRASAAVNAASL"],[115,146,"GQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNK"],[148,179,"KKTPLDLACEFGRLKVAQLLLNSHLCVALLEG"],[189,220,"YTTPLHLAAKNGHREVIRQLLRAGIEINRQTK"],[221,252,"TGTALHEAALYGKTEVVRLLLEGGVDVNIRNT"]]},{"c":"WLxxφxLxxYxxxφψoxGYD(x){7,8}TxE-LoxIGVoKxGHxKKψφxxψxxLxxφ","u":"56-57","sp":"dispersed","x":"structured_like","cf":"high","why":"High-confidence 56-57 aa internal domain duplication separated by a 13-aa linker, sharing 18 identical anchor residues (including WL, L, Y, GYD, T, E, L, IGV, K, GH, KK, and L) plus 9 conserved hydrophobic/polar/acidic positions across a single 1-residue loop length difference.","i":[[497,552,"WLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIA"],[566,622,"WLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAEL"]]}],"s":"MGREQDLILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQHPDGRWKGHIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPEQLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPSYIPTDLLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAELRRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIGTKEQEGTPSASTKHILDDISTMFDALADQLDAMLD"},{"id":"SEQ_05128","a":"Q7RTP6","g":"MICAL3","d":"[F-actin]-monooxygenase MICAL3","L":2002,"m":[{"c":"Cx[FY]Cxxxψ(x){8,10}-GKF[FY][HC]+[SP][CH][FY]x","u":"27-29","sp":"tandem","x":"structured_like","cf":"high","why":"Head-to-tail tandem duplication of a 27-29 aa cysteine/histidine-rich module anchored by an N-terminal Cx[FY]C knuckle, a shared RLSA-containing loop with a 2-aa length difference, and a highly conserved C-terminal -GKF[FY][HC]+[SP][CH][FY]x motif.","i":[[764,790,"CYFCQKRVYVMERLSAEGKFFHRSCFK"],[791,819,"CEYCATTLRLSAYAYDIEDGKFYCKPHYC"]]},{"c":"SPIR[SF][PQ][PQ]","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed copies clustered within a ~130 aa proline/serine-rich disordered region (residues 1156-1284), sharing an invariant SPIR core immediately followed by a constrained [SF][PQ][PQ] extension.","i":[[1156,1162,"SPIRSPQ"],[1221,1227,"SPIRSQP"],[1278,1284,"SPIRFQP"]]}],"s":"MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYWKAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDAFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVNVEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGKLAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFVMTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINHYGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMDSAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLRPSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNVTDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKEMASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQTISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQNKVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAEGKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKEAKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSLRQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDLGGVPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSEAGNQRLQQVMHAADPLEIQADVHWTHIREREEEERMAPASESSASGAPLDENDLEEDVDSEPAEIEGEAAEDGDPGDTGAELDDDQHWSDSPSDADRELRLPCPAEGEAELELRVSEDEEKLPASPKHQERGPSQATSPIRSPQESALLFIPVHSPSTEGPQLPPVPAATQEKSPEERLFPEPLLPKEKPKADAPSDLKAVHSPIRSQPVTLPEARTPVSPGSPQPQPPVAASTPPPSPLPICSQPQPSTEATVPSPTQSPIRFQPAPAKTSTPLAPLPVQSQSDTKDRLGSPLAVDEALRRSDLVEEFWMKSAEIRRSLGLTPVDRSKGPEPSFPTPAFRPVSLKSYSVEKSPQDEGLHLLKPLSIPKRLGLPKPEGEPLSLPTPRSPSDRELRSAQEERRELSSSSGLGLHGSSSNMKTLGSQSFNTSDSAMLTPPSSPPPPPPPGEEPATLRRKLREAEPNASVVPPPLPATWMRPPREPAQPPREEVRKSFVESVEEIPFADDVEDTYDDKTEDSSLQEKFFTPPSCWPRPEKPRHPPLAKENGRLPALEGTLQPQKRGLPLVSAEAKELAEERMRAREKSVKSQALRDAMARQLSRMQQMELASGAPRPRKASSAPSQGKERRPDSPTRPTLRGSEEPTLKHEATSEEVLSPPSDSGGPDGSFTSSEGSSGKSKKRSSLFSPRRNKKEKKSKGEGRPPEKPSSNLLEEAAAKPKSLWKSVFSGYKKDKKKKADDKSCPSTPSSGATVDSGKHRVLPVVRAELQLRRQLSFSEDSDLSSDDVLEKSSQKSRREPRTYTEEELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQVEERQRRLEERGVAVEKALRGEAGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELEDRQSRLQQELRERMAVEDHLKTEEELSEEKQILNEMLEVVEQRDSLVALLEEQRLREREEDKDLEAAMLSKGFSLNWS"},{"id":"SEQ_05136","a":"Q68CQ1","g":"MROH7","d":"Maestro heat-like repeat-containing protein family member 7","L":1323,"m":[{"c":"[PQ]x[SL]xxx[LT][SI][PSL]x[ST]x[ESY]xxxLxS","u":19,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Seven dispersed 19-aa copies across the N-terminal disordered region (residues 59-341) anchored by an N-terminal P-x-S motif, a central L-[SI]-P-x-[ST] core, frequent glutamate at position 13 (5/7 copies), and invariant C-terminal L-x-S anchors.","i":[[59,77,"PDLNDSLSPVSGEASGLVS"],[91,109,"PASLQITSSCSGEALDLDS"],[123,141,"PASNPILSPSSTEAPRLSS"],[196,214,"PSSKALLIPTSNSSLDLDS"],[234,252,"PDSHGTLIPDTNETITLAS"],[294,312,"QASYVTLIPGSSYGISLHS"],[323,341,"PPSCMTLILGSNETLSLDS"]]}],"s":"MALSPGANLVFHEDPKMTPSPPSCGAPGLGSGTIPQPHPDMAQVPMLNLLPSPGLALVPDLNDSLSPVSGEASGLVSENTPRPDDSRAIAPASLQITSSCSGEALDLDSKDVSRPDSQGRLCPASNPILSPSSTEAPRLSSGNHPQSNSEDAFKCLSSKIFKLGQRNSNPSRHELNPFIRHHSREGLVLGHCISRPSSKALLIPTSNSSLDLDSNPLLNMGSRNTSKLNLNVAPDSHGTLIPDTNETITLASHNISESVSKGAFSTTWSTSSKETMNVASSGHSRSDLSVTITQASYVTLIPGSSYGISLHSSTHEPNSTISPPSCMTLILGSNETLSLDSSLLFSDTSTLTLSSQQDDAKDNSIHTVPLEENLESWSEMASIKVGQFPLGFPISNPAGKDAVTLQGIPEGAFDEVTSCLVKVPEKTEGGNNMALVENVTTLQKSQDLLEAEGEKKTMIKKIMRQIQEEPLDSLSSSVRKQAMEILTQLSHTQPTLGMRERSELVNVCVHSVFSLPSVQAMQEKDEAKAETIQALYHQTLEALQTLLKALFIEDPTPAGLKSILEALGPWMNSGKAHERARAVNTNVSVLNHMLLTLPFFMPLGFPALGLLLGRLILHIGDPDEEIGCEALDGIIILYTILELQKRARDKEETNKKELYESNKHFLGPYNPVSPCQNILRVIEEFGDFLGPQQIKDLLLAALEGLKGSSEAPGKDSREMMQLASEVMLSSVLEWYRHRALEVIPEIMQGIYMQLSHIQEPRARQVALLPVSLLASSFMTEVVVALLMCPLPLNSNGAEMWRQLILCKPSCDVRDLLDLLLGSLKEKPVTKEGRASIVPLAAASGLCELLSVNSCMGRVRRIYPQLLLALLIQVHYHIGLNLPGCVAPPKDTKKGAQPSPFVPVRWVVKVVKTLLLRMGCSYETTFLEDQGGWELMEQVESHHRGVALLARAMVQYSCQELCRILYLLIPLLERGDEKHRITATAFFVELLQMEQVRRIPEEYSLGRMAEGLSHHDPIMKVLSIRGLVILARRSEKTAKVKALLPSMVKGLKNMDGMLVVEAVHNLKAVFKGRDQKLMDSAVYVEMLQILLPHFSDAREVVRSSCINLYGKVVQKLRAPRTQAMEEQLVSTLVPLLLTMQEGNSKVSQKCVKTLLRCSYFMAWELPKRAYSRKPWDNQQQTVAKICKCLVNTHRDSAFIFLSQSLEYAKNSRASLRKCSVMFIGSLVPCMESIMTEDRLNEVKAALDNLRHDPEASVCIYAAQVQDHILASCWQNSWLPHGNSWVCYSATTHRWSPSCENLPTSHQRRSWIMQALGSWKMSLKK"},{"id":"SEQ_05144","a":"D6RF30","g":"GOLGA8K","d":"Golgin subfamily A member 8K","L":630,"m":[{"c":"QEER[IL][QR][EK]","u":7,"sp":"tandem","x":"structured_like","cf":"medium","why":"Three head-to-tail tandem 7-aa copies (residues 339-359) share an invariant QEER core followed by a conserved large aliphatic position ([IL]) and constrained polar/charged positions ([QR][EK]), with copies 1 and 3 identical, indicating a local heptad triplication distinct from the surrounding generic coiled-coil region.","i":[[339,345,"QEERIQE"],[346,352,"QEERLRK"],[353,359,"QEERIQE"]]}],"s":"MAEETQHNKLAAAKKKLKEYWQKNSPRVPAGANRNRKTNGSIPEKATSGGCQPPRDSATGFHREGPTSSATLKDLESPCQERAVVLDSRSVEISQLKNTIKSLKQQKKQVEHQLEEEKKANNKKQKAKRVLEVQIQTLNIQKEELNTDLYHMKRSLRYFEEKSKDLAVRLQHSLQRKGELESVLSNVMATQKKKANQLSSRSKARTEWKLEQSMREEALLKVQLTQLKESFQQVQLERDEYSEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSLQQLAKPQSVFEEPNNENKNALQLEQQVKELQEKLGEEHLEAASQQNQQLTAQLSLMALPGEGHGEHLDSEGEEAPQPMPSVPEDLESREAMSSFMDHLKEKADLSELVKKELCFIHHWRDRRHQKTHHLLSEPGGCAKDAALGGGHHQAGAQGGDEGEAAGAAADGIAAYSNYNNGHRKFLAAAHNPADEPGPGAPAPQELGAADKHGDLREVSLTSSAQGEAREDPLLDKPTAQPIVQDHKEHPGLGSNCCVPLFCWAWLPRRRR"},{"id":"SEQ_05147","a":"Q6UB98","g":"ANKRD12","d":"Ankyrin repeat domain-containing protein 12","L":2062,"m":[{"c":"[GD]xTPLHx[AS][AC]xxGxxxxφKxLψxxG[AG][ND]xxxxxxx","u":33,"sp":"tandem","x":"structured_like","cf":"high","why":"Three head-to-tail 33-aa repeats anchored by an invariant TPLH motif, conserved glycines at positions 12 and 24, and a central φKxLψ hydrophobic-basic core.","i":[[185,217,"GETPLHMAAIRGDVKQVKELISLGANVNVKDFA"],[218,250,"GWTPLHEACNVGYYDVAKILIAAGADVNTQGLD"],[251,283,"DDTPLHDSASSGHRDIVKLLLRHGGNPFQANKH"]]}],"s":"MPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFMLESSESQMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPSPKPEVFSNVPERDLSNVSNIHSSFATSPTGASNSKYVSADRNLIKNTAPVNTVMDSPVHLEPSSQVGVIQNKSWEMPVDRLETLSTRDFICPNSNIPDQESSLQSFCNSENKVLKENADFLSLRQTELPGNSCAQDPASFMPPQQPCSFPSQSLSDAESISKHMSLSYVANQEPGILQQKNAVQIISSALDTDNESTKDTENTFVLGDVQKTDAFVPVYSDSTIQEASPNFEKAYTLPVLPSEKDFNGSDASTQLNTHYAFSKLTYKSSSGHEVENSTTDTQVISHEKENKLESLVLTHLSRCDSDLCEMNAGMPKGNLNEQDPKHCPESEKCLLSIEDEESQQSILSSLENHSQQSTQPEMHKYGQLVKVELEENAEDDKTENQIPQRMTRNKANTMANQSKQILASCTLLSEKDSESSSPRGRIRLTEDDDPQIHHPRKRKVSRVPQPVQVSPSLLQAKEKTQQSLAAIVDSLKLDEIQPYSSERANPYFEYLHIRKKIEEKRKLLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSKICIPTITPPPSLSDPLKELFRQQEVVRMKLRLQHSIEREKLIVSNEQEVLRVHYRAARTLANQTLPFSACTVLLDAEVYNVPLDSQSDDSKTSVRDRFNARQFMSWLQDVDDKFDKLKTCLLMRQQHEAAALNAVQRLEWQLKLQELDPATYKSISIYEIQEFYVPLVDVNDDFELTPI"},{"id":"SEQ_05152","a":"Q99490","g":"AGAP2","d":"Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2","L":1192,"m":[{"c":"x[DS]x[EQ]x[LR][GST]x[LQ]xφA[AR]xx[AG]xxψx[AT]x[LI]LLx(x){0,4}[HY]Gxxxx","u":"32-36","sp":"tandem","x":"structured_like","cf":"high","why":"Three tandem 32-36 aa structured repeats (<=2 aa gaps; copy 1 has a 4-aa loop insertion) anchored by conserved φA[AR], aliphatic ψ...ψLL hydrophobic core, and C-terminal [HY]G turn.","i":[[1049,1084,"TSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDT"],[1087,1118,"EDPQLRSPLHLAAELAHVVITQLLLWYGADVA"],[1120,1151,"RDAQGRTALFYARQAGSQLCADILLQHGCPGE"]]},{"c":"S[AI][AT][AT]TP","u":6,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three head-to-tail 6-aa repeats immediately C-terminal to the structured repeat domain in the disordered tail, anchored by N-terminal S and C-terminal TP across two identical copies and one conservative variant.","i":[[1154,1159,"SAATTP"],[1160,1165,"SAATTP"],[1166,1171,"SITATP"]]}],"s":"MSRGAGALQRRTTTYLISLTLVKLESVPPPPPSPSAAAAGAAGARGSETGDPGSPRGAEEPGKKRHERLFHRQDALWISTSSAGTGGAEPPALSPAPASPARPVSPAPGRRLSLWAVPPGPPLSGGLSPDPKPGGAPTSSRRPLLSSPSWGGPEPEGRAGGGIPGSSSPHPGTGSRRLKVAPPPPAPKPCKTVTTSGAKAGGGKGAGSRLSWPESEGKPRVKGSKSSAGTGASVSAAATAAAAGGGGSTASTSGGVGAGAGARGKLSPRKGKSKTLDNSDLHPGPPAGSPPPLTLPPTPSPATAVTAASAQPPGPAPPITLEPPAPGLKRGREGGRASTRDRKMLKFISGIFTKSTGGPPGSGPLPGPPSLSSGSGSRELLGAELRASPKAVINSQEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSAATTPSAATTPSITATPSPRRRSSAASVGRADAPVALV"},{"id":"SEQ_05159","a":"O15037","g":"KHNYN","d":"Protein KHNYN","L":678,"m":[{"c":"[CV]GDRGD","u":6,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three contiguous head-to-tail 6-aa repeats in the central proline/glycine-rich disordered linker with an invariant 5-residue GDRGD core preceded by C or V.","i":[[370,375,"CGDRGD"],[376,381,"CGDRGD"],[382,387,"VGDRGD"]]}],"s":"MPTWGARPASPDRFAVSAEAENKVREQQPHVERIFSVGVSVLPKDCPDNPHIWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFFLDCLAWSTSAHLVPRAPGSLMISGLTEAFVMAQSRVEELAERLSWDFTPGPSSGASQCTGVLRDFSALLQSPGDAHREALLQLPLAVQEELLSLVQEASSGQGPGALASWEGRSSALLGAQCQGVRAPPSDGRESLDTGSMGPGDCRGARGDTYAVEKEGGKQGGPREMDWGWKELPGEEAWEREVALRPQSVGGGARESAPLKGKALGKEEIALGGGGFCVHREPPGAHGSCHRAAQSRGASLLQRLHNGNASPPRVPSPPPAPEPPWHCGDRGDCGDRGDVGDRGDKQQGMARGRGPQWKRGARGGNLVTGTQRFKEALQDPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDITVFVPQWRFSKDAKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYDDRFMVKLAEETDGIIVSNDQFRDLAEESEKWMAIIRERLLPFTFVGNLFMVPDDPLGRNGPTLDEFLKKPARTQGSSKAQHPSRGFAEHGKQQQGREEEKGSGGIRKTRETERLRRQLLEVFWGQDHKVDFILQREPYCRDINQLSEALLSLNF"},{"id":"SEQ_05164","a":"Q9H501","g":"ESF1","d":"ESF1 homolog","L":851,"m":[{"c":"D[QK]RFRxψφ[KH]Dx+FxxxxxxD++x+","u":24,"sp":"tandem","x":"mixed","cf":"high","why":"Tandem N-terminal 24-aa duplication separated by a 1-residue linker (residues 10-33 and 35-58), anchored by invariant D1, R3, F4, R5, D10, F13, and D20 positions alongside conserved basic (+), hydrophobic (ψ7, φ8), and polar/basic ([QK]2, [KH]9) positions.","i":[[10,33,"DQRFRRVAKDPRFWEMPEKDRKVK"],[35,58,"DKRFRAMFHDKKFKLNYAVDKRGR"]]}],"s":"MSSKQEIMSDQRFRRVAKDPRFWEMPEKDRKVKIDKRFRAMFHDKKFKLNYAVDKRGRPISHSTTEDLKRFYDLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLEEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALEEDSESVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDLARGKGNIETSSEDEDDTADLFPEESGFEHAWRELDKDAPRADEITRRLAVCNMDWDRLKAKDLLALFNSFKPKGGVIFSVKIYPSEFGKERMKEEQVQGPVELLSIPEDAPEKDWTSREKLRDYQFKRLKYYYAVVDCDSPETASKIYEDCDGLEFESSCSFIDLRFIPDDITFDDEPKDVASEVNLTAYKPKYFTSAAMGTSTVEITWDETDHERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQRERKEQELTQAIKKKESEIEKESQRKSIDPALSMLIKSIKTKTEQFQARKKQKVK"},{"id":"SEQ_05172","a":"Q99459","g":"CDC5L","d":"Cell division cycle 5-like protein","L":802,"m":[{"c":"WxxxE-ExLxxφφxxφ(x){2,3}QWxxIAxψψxR(x){3,4}QCxx[RH]ΩxxφLD","u":"43-45","sp":"periodic","x":"structured_like","cf":"high","why":"Two strongly conserved ~44-aa N-terminal structured repeats separated by a 7-aa linker, anchored by invariant W, E-E, L, QW, IA, R, QC, and LD positions alongside conserved hydrophobic and aromatic cores.","i":[[11,55,"WRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLD"],[63,105,"WSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLD"]]},{"c":"[GLV]xTP[FLQ][KRH]","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Five non-overlapping 6-aa motifs clustered within the central disordered region (residues 375-445), anchored by an invariant TP dipeptide, basic +2 position ([KRH]), predominantly bulky hydrophobic +1 residue (L/F in 4/5 copies), and [GLV] at -2.","i":[[375,380,"VDTPLK"],[383,388,"LNTPLH"],[394,399,"GVTPQR"],[409,414,"LSTPFR"],[440,445,"GRTPLR"]]}],"s":"MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKAAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEIARQTAEESGITNSASSTLLSEYNVTNNSVALRTPRTPASQDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGAEGLTPRSGTTPKPVINSTPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEMKRMHKAVQKDLPRPSEVNETILRPLNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKTVGFGTNNSEHITYLEHNPYEKFSKEELKKAQDVLVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLYLPGQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRRLECLKEDVQRQQEREKELQHRYADLLLEKETLKSKF"},{"id":"SEQ_05185","a":"Q8WVC0","g":"LEO1","d":"RNA polymerase-associated protein LEO1","L":666,"m":[{"c":"[STD]D--[KRE]xxx","u":8,"sp":"tandem","x":"disordered_like","cf":"high","why":"Twelve-copy tandem repeat array in the central acidic disordered region anchored by invariant D2, a three-residue acidic core (D--), N-terminal S/T/D, a charged fifth position ([KRE]), and recurring K[ILM]QN or [ER]PQ[LA] C-terminal sub-motifs, with mostly 0-1 aa gaps and occasional degenerate 7-8 aa intervening units.","i":[[140,147,"SDDEKWGR"],[154,161,"SDDEKIQN"],[162,169,"SDDEERAQ"],[171,178,"SDEDKLQN"],[180,187,"DDDEKMQN"],[188,195,"TDDEERPQ"],[197,204,"SDDERQQL"],[212,219,"SDDERPVA"],[229,236,"SDDEEQPQ"],[238,245,"SDEEKMQN"],[246,253,"SDDERPQA"],[261,268,"SDDEEEQD"]]},{"c":"-LFGx[DA]x-","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed copies of a short linear motif in the N-terminal disordered region anchored by an invariant LFG core flanked by conserved acidic residues at positions 1 and 8, accounting for all three phenylalanine residues across the entire 360-aa disordered N-terminal half.","i":[[6,13,"DLFGSDAD"],[60,67,"ELFGDDSE"],[313,320,"DLFGGADD"]]}],"s":"MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEEDDD"},{"id":"SEQ_05190","a":"Q9Y215","g":"COLQ","d":"Acetylcholinesterase collagenic tail peptide","L":455,"m":[{"c":"CGDGxxxxGxE[CD][DC]DG[NS]xxxxxxC","u":23,"sp":"dispersed","x":"structured_like","cf":"medium","why":"C-terminal cysteine-rich domain following the collagen G-x-y tract contains a 2-copy 23-aa duplication separated by a 7-residue linker, anchored by N-terminal CGDG, internal GxE[CD][DC]DG[NS], and a C-terminal C.","i":[[375,397,"CGDGLLQPGEECDDGNSDVGDDC"],[405,427,"CGDGHRHEGVEDCDGSDFGYLTC"]]}],"s":"MVVLNPMTLGIYLQLFFLSIVSQPTFINSVLPISAALPSLDQKKRGGHKACCLLTPPPPPLFPPPFFRGGRSPLLSPDMKNLMLELETSQSPCMQGSLGSPGPPGPQGPPGLPGKTGPKGEKGELGRPGRKGRPGPPGVPGMPGPIGWPGPEGPRGEKGDLGMMGLPGSRGPMGSKGYPGSRGEKGSRGEKGDLGPKGEKGFPGFPGMLGQKGEMGPKGEPGIAGHRGPTGRPGKRGKQGQKGDSGVMGPPGKPGPSGQPGRPGPPGPPPAGQLIMGPKGERGFPGPPGRCLCGPTMNVNNPSYGESVYGPSSPRVPVIFVVNNQEELERLNTQNAIAFRRDQRSLYFKDSLGWLPIQLTPFYPVDYTADQHGTCGDGLLQPGEECDDGNSDVGDDCIRCHRAYCGDGHRHEGVEDCDGSDFGYLTCETYLPGSYGDLQCTQYCYIDSTPCRYFT"},{"id":"SEQ_05209","a":"P0CG38","g":"POTEI","d":"POTE ankyrin domain family member I","L":1075,"m":[{"c":"LRSKMGKWC[RC]HCFPCCRGSGKSNVG[TA][SW]GD[QHY]DDS[TA][MF]","u":35,"sp":"tandem","x":"mixed","cf":"high","why":"Three tandem 35-aa N-terminal repeats separated by 2-aa KT linkers, anchored by 29 invariant positions including a conserved WC[RC]HCFPCC Cys/His core and RGSGKSNVG...GDxDDS motif.","i":[[20,54,"LRSKMGKWCRHCFPCCRGSGKSNVGTSGDQDDSTM"],[57,91,"LRSKMGKWCCHCFPCCRGSGKSNVGTSGDHDDSAM"],[94,128,"LRSKMGKWCCHCFPCCRGSGKSNVGAWGDYDDSAF"]]},{"c":"IC[QE]L[LV]SDYKEKQM[LP]K[IY]SSENSNPEQDLKLTSEEESQR[FL]KGSEN[SG]QPEK[MR]SQEPEINKDGDRE[VL]E(x){0,5}EEMKKH[EG]S[NT][NH]VG[LF][LP]ENL[ST]NG[VA]TAGNGDDGLIP[QP]RKSRTPE[NS]QQFPD[NT]E[SN]EEYH","u":"117-122","sp":"tandem","x":"disordered_like","cf":"high","why":"Two tandem 117-aa and 122-aa internal duplications separated by 1 residue in the central polar/acidic disordered region, sharing >80% sequence identity across the entire span with a single 5-aa internal insertion.","i":[[353,469,"ICQLLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRFKGSENSQPEKMSQEPEINKDGDREVEEEMKKHESNNVGLLENLSNGVTAGNGDDGLIPQRKSRTPENQQFPDNESEEYH"],[471,592,"ICELVSDYKEKQMPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIEEMKKHGSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYH"]]},{"c":"[GK]xT[ATP]Lxx[AG]xxxxxxxxφxφL[LI]xxxxxxxxx[DN]xx","u":33,"sp":"tandem","x":"structured_like","cf":"high","why":"Five head-to-tail 33-aa structured repeats defined by a conserved [GK]xT[ATP]Lxx[AG] N-terminal signature and a hydrophobic φxφL[LI] core.","i":[[173,205,"KRTALHLASANGNSGVVKLLLDRRCQLNVLDNK"],[206,238,"KRTALTKAVQCQEDECALMLLEHGTDPNIPDEY"],[239,271,"GNTTLHYAIYNEDKLMAKALLLYGADIESKNKH"],[272,304,"GLTPLLLGVHEQKQQVVKFLIKKKANLNALDRY"],[305,337,"GRTALILAVCCGSASIVSLLLEQNIDVSSQDLS"]]}],"s":"MVAEVDSMPAASSVKKPFVLRSKMGKWCRHCFPCCRGSGKSNVGTSGDQDDSTMKTLRSKMGKWCCHCFPCCRGSGKSNVGTSGDHDDSAMKTLRSKMGKWCCHCFPCCRGSGKSNVGAWGDYDDSAFVEPRYHVRREDLDKLHRAAWWGKVARKDLIVMLRDTDVNKQDKQKRTALHLASANGNSGVVKLLLDRRCQLNVLDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRFKGSENSQPEKMSQEPEINKDGDREVEEEMKKHESNNVGLLENLSNGVTAGNGDDGLIPQRKSRTPENQQFPDNESEEYHRICELVSDYKEKQMPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIEEMKKHGSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQKQFCEEQNTGILHDEILIHEEKQIEVVEKMNSELSLSCKKEKDFLHENSTLREEIAMLRLELDTMKHQSQLRKKKYLEDIESVKKKNDNLLKALQLNELTMDDDTAVLVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRQQGMMGGMHQKESYVGKEAQSKRGILTLKYPMEHGIITNWDDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAMLSLYTSGRTTGIVMDSGDGVTHTVPIYDGNALPHATLRLDLAGRELTDYLMKILTERGYRFTTMAEREIVRDIKEKLCYVALDFEQEMAMAASSSSLEKSYELPDGQVITIGNEWFRCPEALFQPCFLGMESCGIHETTFNSIMKSDVDIRKDLYTNTVLSGGTTMYPGMAHRMQKEIAALAPSMLKIRIIAPPKRKYSVWVGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF"},{"id":"SEQ_05218","a":"Q6PCD5","g":"RFWD3","d":"E3 ubiquitin-protein ligase RFWD3","L":774,"m":[{"c":"AxψφSSQ[GA]xPx[LI]LQP[AV]P","u":17,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three head-to-tail 17-aa repeats in the N-terminal proline/polar-rich disordered tail (residues 24-74, immediately preceded by an additional QPAP motif at 20-23) with invariant A, SSQ, P, LQP, and P anchors flanking conserved aliphatic/hydrophobic positions.","i":[[24,40,"AGMASSQGGPALLQPVP"],[41,57,"ADVVSSQGVPSILQPAP"],[58,74,"AEVISSQATPPLLQPAP"]]}],"s":"MAHEAMEYDVQVQLNHAEQQPAPAGMASSQGGPALLQPVPADVVSSQGVPSILQPAPAEVISSQATPPLLQPAPQLSVDLTEVEVLGEDTVENINPRTSEQHRQGSDGNHTIPASSLHSMTNFISGLQRLHGMLEFLRPSSSNHSVGPMRTRRRVSASRRARAGGSQRTDSARLRAPLDAYFQVSRTQPDLPATTYDSETRNPVSEELQVSSSSDSDSDSSAEYGGVVDQAEESGAVILEEQLAGVSAEQEVTCIDGGKTLPKQPSPQKSEPLLPSASMDEEEGDTCTICLEQWTNAGDHRLSALRCGHLFGYRCISTWLKGQVRKCPQCNKKARHSDIVVLYARTLRALDTSEQERMKSSLLKEQMLRKQAELESAQCRLQLQVLTDKCTRLQRRVQDLQKLTSHQSQNLQQPRGSQAWVLSCSPSSQGQHKHKYHFQKTFTVSQAGNCRIMAYCDALSCLVISQPSPQASFLPGFGVKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNAGRPVWSCCWCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRAASAAFPYGGVLAGTLEDASFWEQKMDFSHWPHVLPLEPGGCIDFQTENSSRHCLVTYRPDKNHTTIRSVLMEMSYRLDDTGNPICSCQPVHTFFGGPTCKLLTKNAIFQSPENDGNILVCTGDEAANSALLWDAASGSLLQDLQTDQPVLDICPFEVNRNSYLATLTEKMVHIYKWE"},{"id":"SEQ_05221","a":"Q14154","g":"DELE1","d":"DAP3-binding cell death enhancer 1","L":515,"m":[{"c":"[DEN]xxxAφxxφxx[AS]AxxGxxx[AS][QR]xxφ[GAR]x[CL]xx[GDE](x){3,7}","u":"34-38","sp":"tandem","x":"structured_like","cf":"high","why":"Five contiguous 34-38 aa structured helical-hairpin repeats (residues 260-438) sharing an ungapped 31-aa core with invariant A and G turn anchors, conserved hydrophobic core positions, [AS]A and [AS][QR] motifs, [CL] packing residues, and a short 3-7 aa C-terminal inter-repeat loop.","i":[[260,295,"DHTAAFSYFQKAAARGYSKAQYNAGLCHEHGRGTPR"],[296,333,"DISKAVLYYQLAASQGHSLAQYRYARCLLRDPASSWNP"],[334,367,"ERQRAVSLLKQAADSGLREAQAFLGVLFTKEPYL"],[368,403,"DEQRAVKYLWLAANNGDSQSRYHLGICYEKGLGVQR"],[404,438,"NLGEALRCYQQSAALGNEAAQERLRALFSMGAAAP"]]}],"s":"MWRLPGLLGRALPRTLGPSLWRVTPKSTSPDGPQTTSSTLLVPVPNLDRSGPHGPGTSGGPRSHGWKDAFQWMSSRVSPNTLWDAISWGTLAVLALQLARQIHFQASLPAGPQRVEHCSWHSPLDRFFSSPLWHPCSSLRQHILPSPDGPAPRHTGLREPRLGQEEASAQPRNFSHNSLRGARPQDPSEEGPGDFGFLHASSSIESEAKPAQPQPTGEKEQDKSKTLSLEEAVTSIQQLFQLSVSIAFNFLGTENMKSGDHTAAFSYFQKAAARGYSKAQYNAGLCHEHGRGTPRDISKAVLYYQLAASQGHSLAQYRYARCLLRDPASSWNPERQRAVSLLKQAADSGLREAQAFLGVLFTKEPYLDEQRAVKYLWLAANNGDSQSRYHLGICYEKGLGVQRNLGEALRCYQQSAALGNEAAQERLRALFSMGAAAPGPSDLTVTGLKSFSSPSLCSLNTLLAGTSRLPHASSTGNLGLLCRSGHLGASLEASSRAIPPHPYPLERSVVRLGFG"},{"id":"SEQ_05225","a":"Q9UF56","g":"FBXL17","d":"F-box/LRR-repeat protein 17","L":701,"m":[{"c":"[CS]xxφxxφxφxx[CN](x){1,2}ψ[ST]Dxxφxxφ(x){2,3}","u":"24-26","sp":"tandem","x":"structured_like","cf":"high","why":"Twelve contiguous head-to-tail 24-26 aa repeats (residues 359-667) with a conserved hydrophobic beta-strand core (φxxφxφ), cysteine/polar position, ψ[ST]D turn motif, and amphipathic φxxφ helical segment.","i":[[359,384,"FQFWKQLDLSSRQQVTDELLEKIASR"],[385,410,"SQNIIEINISDCRSMSDNGVCVLAFK"],[411,436,"CPGLLRYTAYRCKQLSDTSIIAVASH"],[437,462,"CPLLQKVHVGNQDKLTDEGLKQLGSK"],[463,488,"CRELKDIHFGQCYKISDEGMIVIAKG"],[489,514,"CLKLQRIYMQENKLVTDQSVKAFAEH"],[515,538,"CPELQYVGFMGCSVTSKGVIHLTK"],[539,564,"LRNLSSLDLRHITELDNETVMEIVKR"],[565,590,"CKNLSSLNLCLNWIINDRCVEVIAKE"],[591,615,"GQNLKELYLVSCKITDYALIAIGRY"],[616,641,"SMTIETVDVGWCKEITDQGATLIAQS"],[642,667,"SKSLRYLGLMRCDKVNEVTVEQLVQQ"]]}],"s":"MGHLLSKEPRNRPSQKRPRCCSWCRRRRPLLRLPRRTPAKVPPQPAAPRSRDCFFRGPCMLCFIVHSPGAPAPAGPEEEPPLSPPPRDGAYAAASSSQHLARRYAALAAEDCAAAARRFLLSSAAAAAAAAASASSPASCCKELGLAAAAAWEQQGRSLFLASLGPVRFLGPPAAVQLFRGPTPSPAELPTPPEMVCKRKGAGVPACTPCKQPRCGGGGCGGGGGGGGGGGPAGGGASPPRPPDAGCCQAPEQPPQPLCPPPSSPTSEGAPTEAGGDAVRAGGTAPLSAQQQHECGDADCRESPENPCDCHREPPPETPDINQLPPSILLKIFSNLSLDERCLSASLVCKYWRDLCLDFQFWKQLDLSSRQQVTDELLEKIASRSQNIIEINISDCRSMSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCKRTLERAYQMGWTPNMSAASS"},{"id":"SEQ_05226","a":"O95049","g":"TJP3","d":"Tight junction protein ZO-3","L":919,"m":[{"c":"xφGψxψ[SGA](x){2,9}ψφψ[SK]xψxx[GS][GS][LP]A(x){2,4}[RG]ψQ[TE]GDxIψ[MQ]ψN[GD]V[SP]x[EQ]Nφ[ST]xxx[AT]x[QR]φψ(x){8,10}ψ[TLV][VT]xR","u":"66-71","sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed ~70-residue structured repeats in the N-terminal half anchored by an N-terminal φGψxψ motif, a conserved [GS][GS][LP]A turn, a central [RG]ψQ[TE]GDxIψ[MQ]ψN[GD]V...QNφ[ST] core, and a C-terminal ψ[TLV][VT]xR motif separated by disordered linkers.","i":[[21,91,"GFGIAISGGRDRPGGSMVVSDVVPGGPAEGRLQTGDHIVMVNGVSMENATSAFAIQILKTCTKMANITVKR"],[205,270,"EFGVKLGSQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLR"],[391,461,"SIGLRLAGGNDVGIFVSGVQAGSPADGQGIQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQR"]]},{"c":"[EY]TDGEG","u":6,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three tandem copies (gaps of 2 and 0 residues) in the acidic C-terminal disordered tail sharing an invariant TDGEG core with N-terminal Y/E anchors (within the segment SDYETDGEGGAYTDGEGYTDGEGGPYTD).","i":[[808,813,"ETDGEG"],[816,821,"YTDGEG"],[822,827,"YTDGEG"]]}],"s":"MEELTIWEQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPAEGRLQTGDHIVMVNGVSMENATSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKLGSQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSDSSPLEDISDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSIGLRLAGGNDVGIFVSGVQAGSPADGQGIQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSPPSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAKKTTQRSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFEIAETVSRTDSPSKIIKLDTVRVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIWTAEDQLDGSLEDNLDLPHHGLADSSADLSCDSRVNSDYETDGEGGAYTDGEGYTDGEGGPYTDVDDEPPAPALARSSEPVQADESQSPRDRGRISAHQGAQVDSRHPQGQWRQDSMRTYEREALKKKFMRVHDAESSDEDGYDWGPATDL"},{"id":"SEQ_05253","a":"O15381","g":"NVL","d":"Nuclear valosin-containing protein-like","L":856,"m":[{"c":"φoψ[SP]NV[KT]Ω[EA]DψG[GA]x-xx[LR][KE]Eψx[KM]φψψ(x){2,3}R[HN]P-xΩ[HK][HA]LGψV[PT]P[RA]GVLL[HA]GPPGCGKTLLA[HK]AψA[GN]E[LS][DG]Lxφψ[KS]V[AK][AG]PEψψo[GM]φ[SV]GESE[QR][KA]ψR[EQ]ψF[EQ][QR]A[VK]ooAPCψIFφDEψDAψ[TC]P+R[ES]x[AR][SE][KT][DG]φ[ES][RV]RψV[AN]QLLT[CE]MD[DG]L(x){3,6}[AQ][RQ]Vφψψ[GA]ATNRPD[SI]ψDPAψ[RL]R[AP]GRφD+[ET]ψ[CF]ψGψP[DP][EP]A[SD]R[EL][RA]IL[QK]Tψ[CT]+[KN][LG][RT][LK]P(x){16,21}GADL[MS]AL[CV]REA[AS]ψCAψ[NR][RQ][VE]ψ","u":"234-237","sp":"dispersed","x":"structured_like","cf":"high","why":"Two large ~235-residue structured internal duplications separated by an 82-residue linker, exhibiting extensive sequence identity across the entire span including invariant GVLL[HA]GPPGCGKTLLA, APCψIFφDEψDA, ATNRPD, and C-terminal GADL[MS]AL[CV]REA[AS]ψCAψ motifs.","i":[[257,490,"FQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVL"],[573,809,"VTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEM"]]}],"s":"MKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYERLQESLSR"},{"id":"SEQ_05257","a":"Q9UKZ4","g":"TENM1","d":"Teneurin-1","L":2725,"m":[{"c":"C(x){3,4}C[FGSYT][GN]xGx[CYF](x){4,8}CxCxxG[WFY]xGxxC","u":"27-31","sp":"dispersed","x":"structured_like","cf":"high","why":"Eight closely spaced 27-31 aa cysteine-rich structured repeats (4-12 aa linkers) anchored by a conserved six-cysteine framework (with aromatic Y/F substituting at the third position in two copies), an internal GxG turn, a CxC dyad, and a C-terminal G[WFY]xGxxC motif.","i":[[532,558,"CSTNCNGNGECISGHCHCFPGFLGPDC"],[563,589,"CPVLCGGNGEYEKGHCVCRHGWKGPEC"],[596,623,"CIDPTCFGHGTCIMGVCICVPGYKGEIC"],[628,655,"CLDPMCSNHGICVKGECHCSTGWGGVNC"],[662,690,"CQEQCSGHGTFLLDAGVCSCDPKWTGSDC"],[695,721,"CTMECGSHGVCSRGICQCEEGWVGPTC"],[726,752,"CHSHCTEHGQCKDGKCECSPGWEGDHC"],[765,795,"CPGLCFGNGRCTLDQNGWHCVCQVGWSGTGC"]]},{"c":"xφxY[DN]xx[GD]xxxxxxx","u":15,"sp":"dispersed","x":"structured_like","cf":"high","why":"Ten 15-aa beta-shell repeats across the C-terminal half anchored by a strictly conserved hydrophobic residue at position 2, an invariant Y[DN] dyad at positions 4-5, a conserved [GD] turn residue at position 8, and aliphatic core positions at 10-11.","i":[[1652,1666,"VYEYDPEGHLTNATF"],[1820,1834,"RILYDQTGRPILWSP"],[1862,1876,"KMEYDQSGKIISRTW"],[2124,2138,"TIQYDNVGRMVICDI"],[2150,2164,"FYEYDADGQLQTVSV"],[2171,2185,"RYSYDLNGNINLLSH"],[2193,2207,"PLRYDLRDRITRLGE"],[2225,2239,"IFEYNSNGLLQKAYN"],[2247,2261,"QYYYDGLGRRVASKS"],[2293,2307,"SLYYDLQGHLIAMEL"]]},{"c":"[AI]xx[PV](x){1,2}[GN]xψYφxDxxxψ[RL]x[IR]x","u":"20-21","sp":"dispersed","x":"structured_like","cf":"high","why":"Four dispersed 20-21 aa beta-propeller-like blade repeats upstream of the YD-repeat domain, sharing an invariant central YφxD beta-strand core flanked by aliphatic ψ positions.","i":[[1201,1220,"ASGPDGSVYVGDFNFVRRIF"],[1311,1331,"ITVDRHGFIYFVDGTMIRKID"],[1371,1391,"AVNPMDNSLYVLDNNIVLQIS"],[1501,1520,"AVSPDGTLYVADLGNVRIRT"]]}],"s":"MEQTDCKPYQPLPKVKHEMDLAYTSSSDESEDGRKPRQSYNSRETLHEYNQELRMNYNSQSRKRKEVEKSTQEMEFCETSHTLCSGYQTDMHSVSRHGYQLEMGSDVDTETEGAASPDHALRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCCDMEAQAGSTQDVQSSPHNQFTFRPLPPPPPPPHACTCARKPPPAADSLQRRSMTTRSQPSPAAPAPPTSTQDSVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYPLTSNTVYSPPPRPLPRSTFSRPAFTFNKPYRCCNWKCTALSATAITVTLALLLAYVIAVHLFGLTWQLQPVEGELYANGVSKGNRGTESMDTTYSPIGGKVSDKSEKKVFQKGRAIDTGEVDIGAQVMQTIPPGLFWRFQITIHHPIYLKFNISLAKDSLLGIYGRRNIPPTHTQFDFVKLMDGKQLVKQDSKGSDDTQHSPRNLILTSLQETGFIEYMDQGPWYLAFYNDGKKMEQVFVLTTAIEIMDDCSTNCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKGECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQCEEGWVGPTCEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQGSPDPLDLIQQSQTLFSQHTSRLFYDRIKFLIGKDSTHVIPPEVSFDSRRACVIRGQVVAIDGTPLVGVNVSFLHHSDYGFTISRQDGSFDLVAIGGISVILIFDRSPFLPEKRTLWLPWNQFIVVEKVTMQRVVSDPPSCDISNFISPNPIVLPSPLTSFGGSCPERGTIVPELQVVQEEIPIPSSFVRLSYLSSRTPGYKTLLRILLTHSTIPVGMIKVHLTVAVEGRLTQKWFPAAINLVYTFAWNKTDIYGQKVWGLAEALVSVGYEYETCPDFILWEQRTVVLQGFEMDASNLGGWSLNKHHILNPQSGIIHKGNGENMFISQQPPVISTIMGNGHQRSVACTNCNGPAHNNKLFAPVALASGPDGSVYVGDFNFVRRIFPSGNSVSILELSTSPAHKYYLAMDPVSESLYLSDTNTRKVYKLKSLVETKDLSKNFEVVAGTGDQCLPFDQSHCGDGGRASEASLNSPRGITVDRHGFIYFVDGTMIRKIDENAVITTVIGSNGLTSTQPLSCDSGMDITQVRLEWPTDLAVNPMDNSLYVLDNNIVLQISENRRVRIIAGRPIHCQVPGIDHFLVSKVAIHSTLESARAISVSHSGLLFIAETDERKVNRIQQVTTNGEIYIIAGAPTDCDCKIDPNCDCFSGDGGYAKDAKMKAPSSLAVSPDGTLYVADLGNVRIRTISRNQAHLNDMNIYEIASPADQELYQFTVNGTHLHTLNLITRDYVYNFTYNSEGDLGAITSSNGNSVHIRRDAGGMPLWLVVPGGQVYWLTISSNGVLKRVSAQGYNLALMTYPGNTGLLATKSNENGWTTVYEYDPEGHLTNATFPTGEVSSFHSDLEKLTKVELDTSNRENVLMSTNLTATSTIYILKQENTQSTYRVNPDGSLRVTFASGMEIGLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQRKEQNKGNVSAFERRLRAHNRNLLSIDFDHITRTGKIYDDHRKFTLRILYDQTGRPILWSPVSRYNEVNITYSPSGLVTFIQRGTWNEKMEYDQSGKIISRTWADGKIWSYTYLEKSVMLLLHSQRRYIFEYDQPDCLLSVTMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDGRLLQTLHLGTGRRVLYKYTKQARLSEVLYDTTQVTLTYEESSGVIKTIHLMHDGFICTIRYRQTGPLIGRQIFRFSEEGLVNARFDYSYNNFRVTSMQAVINETPLPIDLYRYVDVSGRTEQFGKFSVINYDLNQVITTTVMKHTKIFSANGQVIEVQYEILKAIAYWMTIQYDNVGRMVICDIRVGVDANITRYFYEYDADGQLQTVSVNDKTQWRYSYDLNGNINLLSHGKSARLTPLRYDLRDRITRLGEIQYKMDEDGFLRQRGNDIFEYNSNGLLQKAYNKASGWTVQYYYDGLGRRVASKSSLGQHLQFFYADLTNPIRVTHLYNHTSSEITSLYYDLQGHLIAMELSSGEEYYVACDNTGTPLAVFSSRGQVIKEILYTPYGDIYHDTYPDFQVIIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNHHIWKQLNLLPKPFNLYSFENNYPVGKIQDVAKYTTDIRSWLELFGFQLHNVLPGFPKPELENLELTYELLRLQTKTQEWDPGKTILGIQCELQKQLRNFISLDQLPMTPRYNDGRCLEGGKQPRFAAVPSVFGKGIKFAIKDGIVTADIIGVANEDSRRLAAILNNAHYLENLHFTIEGRDTHYFIKLGSLEEDLVLIGNTGGRRILENGVNVTVSQMTSVLNGRTRRFADIQLQHGALCFNIRYGTTVEEEKNHVLEIARQRAVAQAWTKEQRRLQEGEEGIRAWTEGEKQQLLSTGRVQGYDGYFVLSVEQYLELSDSANNIHFMRQSEIGRR"},{"id":"SEQ_05265","a":"Q5MJ09","g":"SPANXN3","d":"Sperm protein associated with the nucleus on the X chromosome N3","L":141,"m":[{"c":"ED[EK][DG]ψ[DG]x[SC]EG[SP]S[QNK]","u":13,"sp":"tandem","x":"disordered_like","cf":"high","why":"Four head-to-tail 13-residue repeats in the acidic/polar C-terminal tail (residues 85-136) anchored by invariant N-terminal ED and internal EGxS motifs plus a conserved aliphatic residue at position 5.","i":[[85,97,"EDEGVDLSEGSSN"],[98,110,"EDEDLGPCEGPSK"],[111,123,"EDKDLDSSEGSSQ"],[124,136,"EDEDLGLSEGSSQ"]]}],"s":"MEQPTSSTNGEKTKSPCESNNKKNDEMQEVPNRVLAPEQSLKNTKTSEYPIIFVYYLRKGKKINSNQLENEQSQENSINPIQKEEDEGVDLSEGSSNEDEDLGPCEGPSKEDKDLDSSEGSSQEDEDLGLSEGSSQDSGED"},{"id":"SEQ_05272","a":"A6NDN3","g":"GOLGA6B","d":"Golgin subfamily A member 6B","L":693,"m":[{"c":"[KED][QEK]x[EQK][RT]Lx","u":7,"sp":"tandem","x":"mixed","cf":"high","why":"Beyond generic flanking coiled-coil heptads, residues 362-431 form a sequence-specific 10-copy head-to-tail 7-mer array with high pairwise identity around a KQEERLR core, invariant Leu6, near-invariant Arg5 (9/10), and twin RLW copies.","i":[[362,368,"EQNERLR"],[369,375,"EQQKTLQ"],[376,382,"EQGERLR"],[383,389,"KQEQRLR"],[390,396,"KQEERLR"],[397,403,"KEEERLQ"],[404,410,"KQEKRLW"],[411,417,"DQEERLW"],[418,424,"KKEERLQ"],[425,431,"KQEERLA"]]}],"s":"MWPQPYLPPHPMMLEESRQNKLAAAKKKLKEYQQRKSPGIPAGAKTKKKKTDSSPETTTSGGGHSPGDSQYQELAVALESSSVTISQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMERLETINILTLEKADLKTTLYHTKRAARHFEEESKDLAGRLQYSLQRIQELERALCAVSTQQQEEDRSSSCREAVLHRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLKEEKKRDIHRIQELERSLSELKNQMAKPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEVQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLDEEHLEAASQQNQQLETQLSLVALPGEGDGGQHLDSEEEEAPRPTPNIPEDLESREATSSFMDLPKEKADGTEQVERRELGFVQPSGVTDGMRESFTVYESQGAVPNTRHQEMEDVIRLAQKEEEMKVKLLELQELVLPLVGNHEGHGKFLIAAQNPADEPTPGAPAPQELGAAGEQDDFYEVSLDNNVEPAPGAAREGSPHDNPTVQQIVQLSPVMQDT"},{"id":"SEQ_05274","a":"Q13472","g":"TOP3A","d":"DNA topoisomerase 3-alpha","L":1001,"m":[{"c":"[TS]CxC[GS]Q[EP][AS]VxxTV[RQ]K-GPN+GRQF[FH][KT]C(x){4,7}C[NG]FF[LQ]W[AV]D","u":"39-42","sp":"dispersed","x":"structured_like","cf":"high","why":"Two highly conserved 39-42 aa Cys4 zinc-finger-like repeats in the C-terminal region sharing 20 invariant residues (including four conserved cysteines, a QxxVxxTVxK-GPN+GRQF core, and a C[NG]FF[LQ]W[AV]D C-terminal motif) across a minor 4-7 aa variable loop, separated by a 44 aa Gly/Pro/Ser-rich linker.","i":[[812,850,"TCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWAD"],[896,937,"SCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVD"]]}],"s":"MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR"},{"id":"SEQ_05275","a":"Q86SQ0","g":"PHLDB2","d":"Pleckstrin homology-like domain family B member 2","L":1253,"m":[{"c":"+KYSS[SL]","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 6 aa dibasic-tyrosine-serine motifs anchored by [KR]KYSS followed by Ser/Leu within the N-terminal and central disordered regions.","i":[[41,46,"KKYSSS"],[239,244,"RKYSSS"],[809,814,"KKYSSL"]]},{"c":"SCGS[VL]","u":5,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 5 aa cysteine-anchored motifs with invariant SCGS followed by Val/Leu, occurring once in each of the three major disordered regions.","i":[[384,388,"SCGSV"],[521,525,"SCGSL"],[934,938,"SCGSV"]]}],"s":"MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYLTLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSGYPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMWNGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDNYLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL"},{"id":"SEQ_05306","a":"P19338","g":"NUCLEOLIN","d":"Nucleolin","L":710,"m":[{"c":"[TN]L[FLV][VAL][KGS][NG]Lxxxx[ST]xx[ET]L[KQ][ET]x[FI]xxxxx(x){10,14}+[GK]φ[GA]Ω[IV]-Fx[ST]x[EA]D[AL][EK]x[AT]x(x){8,9}Gxx[IV]xL[EDY]x","u":"70-73","sp":"dispersed","x":"structured_like","cf":"high","why":"Four ~70-73 aa globular repeats across the central region anchored by an N-terminal [TN]L[FLV][VAL][KGS][NG]L hydrophobic core, a conserved +[GK]φ[GA]Ω[IV]-F aromatic/hydrophobic motif, a downstream acidic D[AL][EK] helix segment, and a C-terminal Gxx[IV]xL[EDY]x strand separated by short linkers (11-23 aa).","i":[[308,380,"NLFVGNLNFNKSAPELKTGISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEK"],[394,463,"TLLAKNLPYKVTQDELKEVFEDAAEIRLVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYY"],[487,557,"TLVLSNLSYSATEETLQEVFEKATFIKVPQNQNGKSKGYAFIEFASFEDAKEALNSCNKREIEGRAIRLEL"],[573,644,"TLFVKGLSEDTTEETLKESFDGSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDW"]]},{"c":"[ST]P[AGT]K[KA]x[AVT]","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Eight consecutive 7-aa motifs in the N-terminal disordered tail separated by 0-2 aa gaps, strictly anchored by [ST]P, a small residue [AGT], a basic K[KA] pair, and small/aliphatic C-terminal positions.","i":[[67,73,"SPTKKVA"],[76,82,"TPAKKAA"],[84,90,"TPGKKAA"],[92,98,"TPAKKTV"],[99,105,"TPAKAVT"],[106,112,"TPGKKGA"],[113,119,"TPGKALV"],[121,127,"TPGKKGA"]]},{"c":"GGFGGRG[GR]","u":8,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Four 8-aa repeats in the C-terminal Gly/Arg-rich tail (with 0-5 aa gaps) where aromatic F and basic R anchors occur in a fixed GGFGGRG[GR] register rather than unanchored RGG tripeptides.","i":[[651,658,"GGFGGRGG"],[661,668,"GGFGGRGG"],[674,681,"GGFGGRGR"],[682,689,"GGFGGRGG"]]}],"s":"MVKLAKAGKNQGDPKKMAPPPKEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVVSPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVATPGKKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKSAPELKTGISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGKDSKKERDARTLLAKNLPYKVTQDELKEVFEDAAEIRLVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGEKGQNQDYRGGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNQNGKSKGYAFIEFASFEDAKEALNSCNKREIEGRAIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFDGSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDHKPQGKKTKFE"},{"id":"SEQ_05308","a":"O14639","g":"ABLIM1","d":"Actin-binding LIM protein 1","L":778,"m":[{"c":"CxxC(x){5,6}Gx[VA][LV]xxxxK[HTQ]ΩH[PIL]xC[FA]xC[KTS]xC(x){5,6}G[GDE]xφxx[NDQ]Gxxxxxx[DL][CY]","u":52,"sp":"dispersed","x":"structured_like","cf":"high","why":"Four 52-aa cysteine/histidine-rich structured repeats separated by 7-16 aa linkers, each preserving dual metal-coordinating clusters (CxxC...ΩHxxC[FA]xCxxC and a C-terminal G[GDE]xφxx[NDQ]G...[DL][CY] core) with fixed glycine, aromatic, and hydrophobic anchors.","i":[[99,150,"CHKCGEPCKGEVLRVQTKHFHIKCFTCKVCGCDLAQGGFFIKNGEYLCTLDY"],[158,209,"CHGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLC"],[226,277,"CAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGEYISKDGAPYCEKDY"],[285,336,"CEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFTEGEEMYLQGSTVWHPDC"]]}],"s":"MPAFLGLKCLGKLCSSEKSKVTSSERTSARGSNRKRLIVEDRRVSGTSFTAHRRATITHLLYLCPKDYCPRGRVCNSVDPFVAHPQDPHHPSEKPVIHCHKCGEPCKGEVLRVQTKHFHIKCFTCKVCGCDLAQGGFFIKNGEYLCTLDYQRMYGTRCHGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPKETTFSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGEYISKDGAPYCEKDYQGLFGVKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFTEGEEMYLQGSTVWHPDCKQSTKTEEKLRPTRTSSESIYSRPGSSIPGSPGHTIYAKVDNEILDYKDLAAIPKVKAIYDIERPDLITYEPFYTSGYDDKQERQSLGESPRTLSPTPSAEGYQDVRDRMIHRSTSQGSINSPVYSRHSYTPTTSRSPQHFHRPGNEPSSGRNSPLPYRPDSRPLTPTYAQAPKHFHVPDQGINIYRKPPIYKQHAALAAQSKSSEDIIKFSKFPAAQAPDPSETPKIETDHWPGPPSFAVVGPDMKRRSSGREEDDEELLRRRQLQEEQLMKLNSGLGQLILKEEMEKESRERSSLLASRYDSPINSASHIPSSKTASLPGYGRNGLHRPVSTDFAQYNSYGDVSGGVRDYQTLPDGHMPAMRMDRGVSMPNMLEPKIFPYEMLMVTNRGRNKILREVDRTRLERHLAPEVFREIFGMSIQEFDRLPLWRRNDMKKKAKLF"},{"id":"SEQ_05316","a":"O14594","g":"NCAN","d":"Neurocan core protein","L":1321,"m":[{"c":"EψxG[VE]VF[HY]φx[SP]AR(x){10,13}CR[LR]o[SG]AφψA[AS]xx[HQ]L[QH]φAΩ[EH]-GφDoCD[AP]GWL[SA]Dx[TS]VRYPIoo[SP]RxxC(x){4,7}PGVR[ST]φ(x){6,13}E[LR]ΩDφYCF[AR][RA]","u":"101-102","sp":"tandem","x":"structured_like","cf":"high","why":"Head-to-tail 101-102 aa internal duplication anchored by four conserved cysteines and extensive invariant blocks including EVF/VVF, CR, CD[AP]GWL[SA]Dx[TS]VRYPI, PGVR[ST]φ, and E[LR]ΩDφYCF.","i":[[156,256,"EVTGVVFHYRSARDRYALTFAEAQEACRLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRYPITQSRPGCYGDRSSLPGVRSYGRRNPQELYDVYCFAR"],[257,358,"ELGGEVFYVGPARRLTLAGARAQCRRQGAALASVGQLHLAWHEGLDQCDPGWLADGSVRYPIQTPRRRCGGPAPGVRTVYRFANRTGFPSPAERFDAYCFRA"]]},{"c":"D[PD]Cxx[NS]PCx[HN]GGTCxxxxoxΩxCxCxx[GS]Ω[AG]G[ES]xCE","u":35,"sp":"periodic","x":"structured_like","cf":"high","why":"Two gapless 35-aa cysteine-rich repeats separated by a 3-residue linker, sharing six identically spaced cysteines (CxxxxPCxxGGTC, CxC, CE) plus invariant D, P, GGTC, G, and aromatic positions.","i":[[1010,1044,"DPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCE"],[1048,1082,"DDCLCSPCENGGTCIDEVNGFVCLCLPSYGGSFCE"]]}],"s":"MGAPFVWALGLLMLQMLLFVAGEQGTQDITDASERGLHMQKLGSGSVQAALAELVALPCLFTLQPRPSAARDAPRIKWTKVRTASGQRQDLPILVAKDNVVRVAKSWQGRVSLPSYPRRRANATLLLGPLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVVFHYRSARDRYALTFAEAQEACRLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRYPITQSRPGCYGDRSSLPGVRSYGRRNPQELYDVYCFARELGGEVFYVGPARRLTLAGARAQCRRQGAALASVGQLHLAWHEGLDQCDPGWLADGSVRYPIQTPRRRCGGPAPGVRTVYRFANRTGFPSPAERFDAYCFRAHHPTSQHGDLETPSSGDEGEILSAEGPPVRELEPTLEEEEVVTPDFQEPLVSSGEEETLILEEKQESQQTLSPTPGDPMLASWPTGEVWLSTVAPSPSDMGAGTAASSHTEVAPTDPMPRRRGRFKGLNGRYFQQQEPEPGLQGGMEASAQPPTSEAAVNQMEPPLAMAVTEMLGSGQSRSPWADLTNEVDMPGAGSAGGKSSPEPWLWPPTMVPPSISGHSRAPVLELEKAEGPSARPATPDLFWSPLEATVSAPSPAPWEAFPVATSPDLPMMAMLRGPKEWMLPHPTPISTEANRVEAHGEATATAPPSPAAETKVYSLPLSLTPTGQGGEAMPTTPESPRADFRETGETSPAQVNKAEHSSSSPWPSVNRNVAVGFVPTETATEPTGLRGIPGSESGVFDTAESPTSGLQATVDEVQDPWPSVYSKGLDASSPSAPLGSPGVFLVPKVTPNLEPWVATDEGPTVNPMDSTVTPAPSDASGIWEPGSQVFEEAESTTLSPQVALDTSIVTPLTTLEQGDKVGVPAMSTLGSSSSQPHPEPEDQVETQGTSGASVPPHQSSPLGKPAVPPGTPTAASVGESASVSSGEPTVPWDPSSTLLPVTLGIEDFELEVLAGSPGVESFWEEVASGEEPALPGTPMNAGAEEVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINSFGHENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPCNYNLPYVCKKGTVLCGPPPAVENASLIGARKAKYNVHATVRYQCNEGFAQHHVATIRCRSNGKWDRPQIVCTKPRRSHRMRRHHHHHQHHHQHHHHKSRKERRKHKKHPTEDWEKDEGNFC"},{"id":"SEQ_05341","a":"O60245","g":"PCDH7","d":"Protocadherin-7","L":1069,"m":[{"c":"(x){23,33}D(x){54,116}P(x){10,13}φx[DN]x[NS][DV][NS]x[PA]xφ","u":"103-165","sp":"tandem","x":"structured_like","cf":"high","why":"Seven head-to-tail ~103-165 aa structured repeats (copy 2 contains an internal G-rich loop insertion) sharing conserved DxDxGxN, [LI]DRE, and C-terminal GxP-(x)10-13-φxDxNDNxPxφ signature motifs (degenerated to FVNESVSNATA in copy 7).","i":[[31,143,"KQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTF"],[144,308,"PSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRF"],[309,415,"EKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSI"],[416,535,"EIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMF"],[536,639,"GQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKF"],[640,742,"MQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTV"],[743,848,"TLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATA"]]}],"s":"MLRMRTAGWARGWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPNGQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQMRLHPYITVFG"},{"id":"SEQ_05348","a":"P23771","g":"GATA3","d":"Trans-acting T-cell-specific transcription factor GATA-3","L":443,"m":[{"c":"GxxCφNCxxT[ST]TxLWRR[DN][GA]oGxxψCNACGLY[HY]KψxxxNRPL","u":41,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two highly conserved 41-aa structured repeats (23/41 identical residues) anchored by paired CxxC and CNAC cysteine motifs, an invariant LWRR core, and a C-terminal GLY[HY]KψxxxNRPL signature separated by a 13-aa basic linker.","i":[[260,300,"GRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPL"],[314,354,"GTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPL"]]}],"s":"MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFNIDGQGNHVPPYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKTSIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDEKECLKYQVPLPDSMKLESSHSRGSMTALGGASSSTHHPITTYPPYVPEYSSGLFPPSSLLGGSPTGFGCKSRPKARSSTGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRKMSSKSKKCKKVHDSLEDFPKNSSFNPAALSRHMSSLSHISPFSHSSHMLTTPTPMHPPSSLSFGPHHPSSMVTAMG"},{"id":"SEQ_05383","a":"Q12873","g":"CHD3","d":"ATP-dependent chromatin remodeler CHD3","L":2000,"m":[{"c":"DHx-YCxVCxxGGEψψxCDxCxxxYHψxCL[DN]PxLxxφPxGxWxCP[HR]C","u":47,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 47-aa cysteine/histidine-rich structured repeats (21 identical positions including seven Cys, two His, two Tyr, and a C-terminal GxWxCP[HR]C motif, plus conserved aliphatic and acidic sites) separated by a 30-aa acidic linker.","i":[[377,423,"DHQDYCEVCQQGGEIILCDTCPRAYHLVCLDPELDRAPEGKWSCPHC"],[454,500,"DHMEYCRVCKDGGELLCCDACISSYHIHCLNPPLPDIPNGEWLCPRC"]]}],"s":"MKAADTVILWARSKNDQLRISFPPGLCWGDRMPDKDDIRLLPSALGVKKRKRGPKKQKENKPGKPRKRKKRDSEEEFGSERDEYREKSESGGSEYGTGPGRKRRRKHREKKEKKTKRRKKGEGDGGQKQVEQKSSATLLLTWGLEDVEHVFSEEDYHTLTNYKAFSQFMRPLIAKKNPKIPMSKMMTILGAKWREFSANNPFKGSAAAVAAAAAAAAAAVAEQVSAAVSSATPIAPSGPPALPPPPAADIQPPPIRRAKTKEGKGPGHKRRSKSPRVPDGRKKLRGKKMAPLKIKLGLLGGKRKKGGSYVFQSDEGPEPEAEESDLDSGSVHSASGRPDGPVRTKKLKRGRPGRKKKKVLGCPAVAGEEEVDGYETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLDPELDRAPEGKWSCPHCEKEGVQWEAKEEEEEYEEEGEEEGEKEEEDDHMEYCRVCKDGGELLCCDACISSYHIHCLNPPLPDIPNGEWLCPRCTCPVLKGRVQKILHWRWGEPPVAVPAPQQADGNPDVPPPRPLQGRSEREFFVKWVGLSYWHCSWAKELQLEIFHLVMYRNYQRKNDMDEPPPLDYGSGEDDGKSDKRKVKDPHYAEMEEKYYRFGIKPEWMTVHRIINHSVDKKGNYHYLVKWRDLPYDQSTWEEDEMNIPEYEEHKQSYWRHRELIMGEDPAQPRKYKKKKKELQGDGPPSSPTNDPTVKYETQPRFITATGGTLHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLSTIINWEREFQMWAPKFYVVTYTGDKDSRAIIRENEFSFEDNAIKGGKKAFKMKREAQVKFHVLLTSYELITIDQAALGSIRWACLVVDEAHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSPMQKKYYKYILTRNFEALNSRGGGNQVSLLNIMMDLKKCCNHPYLFPVAAMESPKLPSGAYEGGALIKSSGKLMLLQKMLRKLKEQGHRVLIFSQMTKMLDLLEDFLDYEGYKYERIDGGITGALRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIFDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKAGSMSKQELDDILKFGTEELFKDENEGENKEEDSSVIHYDNEAIARLLDRNQDATEDTDVQNMNEYLSSFKVAQYVVREEDKIEEIEREIIKQEENVDPDYWEKLLRHHYEQQQEDLARNLGKGKRVRKQVNYNDAAQEDQDNQSEYSVGSEEEDEDFDERPEGRRQSKRQLRNEKDKPLPPLLARVGGNIEVLGFNTRQRKAFLNAVMRWGMPPQDAFTTQWLVRDLRGKTEKEFKAYVSLFMRHLCEPGADGSETFADGVPREGLSRQQVLTRIGVMSLVKKKVQEFEHINGRWSMPELMPDPSADSKRSSRASSPTKTSPTTPEASATNSPCTSKPATPAPSEKGEGIRTPLEKEEAENQEEKPEKNSRIGEKMETEADAPSPAPSLGERLEPRKIPLEDEVPGVPGEMEPEPGYRGDREKSATESTPGERGEEKPLDGQEHRERPEGETGDLGKREDVKGDRELRPGPRDEPRSNGRREEKTEKPRFMFNIADGGFTELHTLWQNEERAAISSGKLNEIWHRRHDYWLLAGIVLHGYARWQDIQNDAQFAIINEPFKTEANKGNFLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNLSQEPAHPAMALHARFAEAECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKADVTRLPATLSRIPPIAARLQMSERSILSRLASKGTEPHPTPAYPPGPYATPPGYGAAFSAAPVGALAAAGANYSQMPAGSFITAATNGPPVLVKKEKEMVGALVSDGLDRKEPRAGEVICIDD"},{"id":"SEQ_05387","a":"A6NNM3","g":"RIMBP3B","d":"RIMS-binding 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loop.","i":[[835,897,"KIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQI"],[1455,1518,"RVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNIPGRLVAEM"],[1572,1634,"KIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHLLDHM"]]}],"s":"MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQIPDSYIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGMVDRGLCQMVRVGSKTEVATEILDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRVRVEVRLPWDLLQVYWGTMSSTVTFDTLLAGPPYPPLEVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVADATAGSTVLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYTCGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNLGSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCYQHMGTSKSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLKEEQEALCLDLRGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPRGGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGHLPSVAHLEDFQGLTIPQGSSLVLQGNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHLLDHMSLHGH"},{"id":"SEQ_05406","a":"P56715","g":"RP1","d":"Oxygen-regulated 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position.","i":[[1273,1284,"TCNPSDTFFPSD"],[1302,1313,"VCSLTDTVFSDK"],[1326,1337,"ACPIDETYVPVN"],[1338,1349,"VCNTIDFLNSKE"]]}],"s":"MSDTPSTGFSIIHPTSSEGQVPPPRHLSLTHPVVAKRISFYKSGDPQFGGVRVVVNPRSFKSFDALLDNLSRKVPLPFGVRNISTPRGRHSITRLEELEDGESYLCSHGRKVQPVDLDKARRRPRPWLSSRAISAHSPPHPVAVAAPGMPRPPRSLVVFRNGDPKTRRAVLLSRRVTQSFEAFLQHLTEVMQRPVVKLYATDGRRVPSLQAVILSSGAVVAAGREPFKPGNYDIQKYLLPARLPGISQRVYPKGNAKSESRKISTHMSSSSRSQIYSVSSEKTHNNDCYLDYSFVPEKYLALEKNDSQNLPIYPSEDDIEKSIIFNQDGTMTVEMKVRFRIKEEETIKWTTTVSKTGPSNNDEKSEMSFPGRTESRSSGLKLAACSFSADVSPMERSSNQEGSLAEEINIQMTDQVAETCSSASWENATVDTDIIQGTQDQAKHRFYRPPTPGLRRVRQKKSVIGSVTLVSETEVQEKMIGQFSYSEERESGENKSEYHMFTHSCSKMSSVSNKPVLVQINNNDQMEESSLERKKENSLLKSSAISAGVIEITSQKMLEMSHNNGLPSTISNNSIVEEDVVDCVVLDNKTGIKNFKTYGNTNDRFSPISADATHFSSNNSGTDKNISEAPASEASSTVTARIDRLINEFAQCGLTKLPKNEKKILSSVASKKKKKSRQQAINSRYQDGQLATKGILNKNERINTKGRITKEMIVQDSDSPLKGGILCEEDLQKSDTVIESNTFCSKSNLNSTISKNFHRNKLNTTQNSKVQGLLTKRKSRSLNKISLGAPKKREIGQRDKVFPHNESKYCKSTFENKSLFHVFNILEQKPKDFYAPQSQAEVASGYLRGMAKKSLVSKVTDSHITLKSQKKRKGDKVKASAILSKQHATTRANSLASLKKPDFPEAIAHHSIQNYIQSWLQNINPYPTLKPIKSAPVCRNETSVVNCSNNSFSGNDPHTNSGKISNFVMESNKHITKIAGLTGDNLCKEGDKSFIANDTGEEDLHETQVGSLNDAYLVPLHEHCTLSQSAINDHNTKSHIAAEKSGPEKKLVYQEINLARKRQSVEAAIQVDPIEEETPKDLLPVLMLHQLQASVPGIHKTQNGVVQMPGSLAGVPFHSAICNSSTNLLLAWLLVLNLKGSMNSFCQVDAHKATNKSSETLALLEILKHIAITEEADDLKAAVANLVESTTSHFGLSEKEQDMVPIDLSANCSTVNIQSVPKCSENERTQGISSLDGGCSASEACAPEVCVLEVTCSPCEMCTVNKAYSPKETCNPSDTFFPSDGYGVDQTSMNKACFLGEVCSLTDTVFSDKACAQKENHTYEGACPIDETYVPVNVCNTIDFLNSKENTYTDNLDSTEELERGDDIQKDLNILTDPEYKNGFNTLVSHQNVSNLSSCGLCLSEKEAELDKKHSSLDDFENCSLRKFQDENAYTSFDMEEPRTSEEPGSITNSMTSSERNISELESFEELENHDTDIFNTVVNGGEQATEELIQEEVEASKTLELIDISSKNIMEEKRMNGIIYEIISKRLATPPSLDFCYDSKQNSEKETNEGETKMVKMMVKTMETGSYSESSPDLKKCIKSPVTSDWSDYRPDSDSEQPYKTSSDDPNDSGELTQEKEYNIGFVKRAIEKLYGKADIIKPSFFPGSTRKSQVCPYNSVEFQCSRKASLYDSEGQSFGSSEQVSSSSSMLQEFQEERQDKCDVSAVRDNYCRGDIVEPGTKQNDDSRILTDIEEGVLIDKGKWLLKENHLLRMSSENPGMCGNADTTSVDTLLDNNSSEVPYSHFGNLAPGPTMDELSSSELEELTQPLELKCNYFNMPHGSDSEPFHEDLLDVRNETCAKERIANHHTEEKGSHQSERVCTSVTHSFISAGNKVYPVSDDAIKNQPLPGSNMIHGTLQEADSLDKLYALCGQHCPILTVIIQPMNEEDRGFAYRKESDIENFLGFYLWMKIHPYLLQTDKNVFREENNKASMRQNLIDNAIGDIFDQFYFSNTFDLMGKRRKQKRINFLGLEEEGNLKKFQPDLKERFCMNFLHTSLLVVGNVDSNTQDLSGQTNEIFKAVDENNNLLNNRFQGSRTNLNQVVRENINCHYFFEMLGQACLLDICQVETSLNISNRNILELCMFEGENLFIWEEEDILNLTDLESSREQEDL"},{"id":"SEQ_05415","a":"Q969E4","g":"TCEAL3","d":"Transcription elongation factor A protein-like 3","L":200,"m":[{"c":"x[EQ]G+x-","u":6,"sp":"tandem","x":"disordered_like","cf":"high","why":"Contiguous 13-copy head-to-tail hexapeptide tandem array (residues 8-85) in the N-terminal disordered region anchored by conserved [EQ] at position 2 (13/13), G at position 3 (11/13, with two degenerate internal units DEVEPD and EEEKPD), frequent K/R at position 4 and P at position 5, and acidic D/E at position 6 (10/13).","i":[[8,13,"NEGNLE"],[14,19,"NEGKPE"],[20,25,"DEVEPD"],[26,31,"DEGKSD"],[32,37,"EEEKPD"],[38,43,"VEGKTE"],[44,49,"CEGKRE"],[50,55,"DEGEPG"],[56,61,"DEGQLE"],[62,67,"DEGSQE"],[68,73,"KQGRSE"],[74,79,"GEGKPQ"],[80,85,"GEGKPA"]]}],"s":"MEKPYNKNEGNLENEGKPEDEVEPDDEGKSDEEEKPDVEGKTECEGKREDEGEPGDEGQLEDEGSQEKQGRSEGEGKPQGEGKPASQAKPESQPRAAEKRPAEDYVPRKAKRKTDRGTDDSPKDSQEDLQERHLSSEEMMRECGDVSRAQEELRKKQKMGGFHWMQRDVQDPFAPRGQRGVRGVRGGGRGQRGLHDIPYL"},{"id":"SEQ_05417","a":"Q8WY91","g":"THAP4","d":"Peroxynitrite isomerase 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gaps.","i":[[211,243,"TDKSGISMDDFTPPGSGACKFIGSLHSYSFSSK"],[321,353,"SDASPMSINEVILSASGACKLIDSLHSYCFSSR"]]}],"s":"MVICCAAVNCSNRQGKGEKRAVSFHRFPLKDSKRLIQWLKAVQRDNWTPTKYSFLCSEHFTKDSFSKRLEDQHRLLKPTAVPSIFHLTEKKRGAGGHGRTRRKDASKATGGVRGHSSAATSRGAAGWSPSSSGNPMAKPESRRLKQAALQGEATPRAAQEAASQEQAQQALERTPGDGLATMVAGSQGKAEASATDAGDESATSSIEGGVTDKSGISMDDFTPPGSGACKFIGSLHSYSFSSKHTRERPSVPREPIDRKRLKKDVEPSCSGSSLGPDKGLAQSPPSSSLTATPQKPSQSPSAPPADVTPKPATEAVQSEHSDASPMSINEVILSASGACKLIDSLHSYCFSSRQNKSQVCCLREQVEKKNGELKSLRQRVSRSDSQVRKLQEKLDELRRVSVPYPSSLLSPSREPPKMNPVVEPLSWMLGTWLSDPPGAGTYPTLQPFQYLEEVHISHVGQPMLNFSFNSFHPDTRKPMHRECGFIRLKPDTNKVAFVSAQNTGVVEVEEGEVNGQELCIASHSIARISFAKEPHVEQITRKFRLNSEGKLEQTVSMATTTQPMTQHLHVTYKKVTP"},{"id":"SEQ_05432","a":"Q5EBL2","g":"ZNF628","d":"Zinc finger protein 628","L":1059,"m":[{"c":"[YFH]xCxxC[GPD]xxFxxxxx[LY]xxH[QLR]xxH","u":23,"sp":"dispersed","x":"structured_like","cf":"high","why":"Sixteen 23-aa repeats defined by invariant CxxC and HxxxH coordination anchors plus conserved aromatic/aliphatic core positions ([YFH] at position 1, F at position 10, [LY] at position 16), arranged mainly in two 5-aa-linked arrays separated by proline-rich regions.","i":[[36,58,"YECGECGKSFRWSSRLLHHQRTH"],[64,86,"YKCPDCPKAFKGSSALLYHQRGH"],[92,114,"YQCPDCPKAFKRSSLLQIHRSVH"],[120,142,"FICGQCGLAFKWSSHYQYHLRQH"],[148,170,"YPCPDCPKAFKNSSSLRRHRHVH"],[176,198,"YTCGVCGKSFTQSTNLRQHQRVH"],[204,226,"FRCPLCPKTFTHSSNLLLHQRTH"],[356,378,"FACLPCGKSFRTVAGLSRHQHSH"],[386,408,"FRCGSCDGSFPQLASLLAHQQCH"],[454,476,"YKCAECGKSFKGSSGLRYHLRDH"],[482,504,"YQCGECGKAFKRSSLLAIHQRVH"],[510,532,"FTCGQCGLTFKWSSHYQYHLRLH"],[538,560,"YACGECGKAFRNTSCLRRHRHVH"],[566,588,"HACGVCGKSFAQTSNLRQHQRVH"],[594,616,"FRCPLCPKTFTHSSNLLLHQRTH"],[622,644,"FTCPICGRGFVMAAYLQRHLRTH"]]},{"c":"PA[PQ]EVTTVQLQ","u":11,"sp":"tandem","x":"disordered_like","cf":"high","why":"Four head-to-tail tandem 11-aa repeats in the C-terminal disordered-like region with 10 of 11 positions invariant across all copies (PAxEVTTVQLQ, varying only P/Q at position 3).","i":[[825,835,"PAPEVTTVQLQ"],[836,846,"PAQEVTTVQLQ"],[847,857,"PAQEVTTVQLQ"],[858,868,"PAQEVTTVQLQ"]]}],"s":"MSGVMVGSHADMAPASTAEGAGEKPGPAAPAPAAQYECGECGKSFRWSSRLLHHQRTHTGERPYKCPDCPKAFKGSSALLYHQRGHTGERPYQCPDCPKAFKRSSLLQIHRSVHTGLRAFICGQCGLAFKWSSHYQYHLRQHTGERPYPCPDCPKAFKNSSSLRRHRHVHTGERPYTCGVCGKSFTQSTNLRQHQRVHTGERPFRCPLCPKTFTHSSNLLLHQRTHGAAPAPGTASAAPPPQSREPGKVFVCDAYLQRHLQPHSPPAPPAPPPPPPPVVPELFLAAAETTVELVYRCDGCEQGFSSEELLLEHQPCPGPDAAPQPQEAPAEAPKADQPPSPLPQPPPPAAAPAPGFACLPCGKSFRTVAGLSRHQHSHGAAGGQAFRCGSCDGSFPQLASLLAHQQCHVEEAAAGRPPPQAEAAEVTCPQEPLAPAAPVPPPPPSAPASAERPYKCAECGKSFKGSSGLRYHLRDHTGERPYQCGECGKAFKRSSLLAIHQRVHTGLRAFTCGQCGLTFKWSSHYQYHLRLHSGERPYACGECGKAFRNTSCLRRHRHVHTGERPHACGVCGKSFAQTSNLRQHQRVHTGERPFRCPLCPKTFTHSSNLLLHQRTHSAERPFTCPICGRGFVMAAYLQRHLRTHAPANTPPSTTAPAAGPQPPAPLAAARAPPATQDVHVLPHLQATLSLEVAGGTAQAPSLGPAAPNSQTFLLVQTAQGLQLIPSSVQPPTPPPPPAPPKLILLPSSSAGAGGGRARQGPRAVGKAGQGAGVVWLPGPGGLGVQGAASAGASGTGQSLIVLQNVGGGEAGPQEMSGVQLQPLRPAPEVTTVQLQPAQEVTTVQLQPAQEVTTVQLQPAQEVTTVQLQPVAGQLSNSSGGAVATEAPNLLVVQSGAAEELLTGPGPGEAGDGEASTGVVQDVLFETLQTDEGLQSVLVLSGADGEQTRLCVQEVETLPPGLTEPPATGPPGQKLLIIRSAPATELLDSSNTGGGTATLQLLAPPPSGPASGPAGLPGAPASQMVQVVPAGAGPGVMTPQGLPSIQIVQTLPAVQLVHTF"},{"id":"SEQ_05440","a":"Q96KN7","g":"RPGRIP1","d":"X-linked retinitis pigmentosa GTPase regulator-interacting protein 1","L":1286,"m":[{"c":"TQP[ST]xΩxxYxFΩxFFxxHxTxψxx[GA]x[QN]xxY(x){15,16}HYL","u":"47-48","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of a 47-48 aa structured segment sharing 12 invariant anchor residues (N-terminal TQP, aromatic core YxFΩxFF, HxTxψ, Y, and C-terminal HYL) plus conserved physicochemical positions across a 15-16 aa internal loop, separated by a 123 aa linker.","i":[[648,694,"TQPTTFCTYSFYDFETHCTPLSVGPQPLYDFTSQYVMETDSLFLHYL"],[818,865,"TQPSPYAVYRFFTFSDHDTAIIPASNNPYFRDQARFPVLVTSDLDHYL"]]}],"s":"MSHLVDPTSGDLPVRDIDAIPLVLPASKGKNMKTQPPLSRMNREELEDSFFRLREDHMLVKELSWKQQDEIKRLRTTLLRLTAAGRDLRVAEEAAPLSETARRGQKAGWRQRLSMHQRPQMHRLQGHFHCVGPASPRRAQPRVQVGHRQLHTAGAPVPEKPKRGPRDRLSYTAPPSFKEHATNENRGEVASKPSELVSGSNSIISFSSVISMAKPIGLCMPNSAHIMASNTMQVEEPPKSPEKMWPKDENFEQRSSLECAQKAAELRASIKEKVELIRLKKLLHERNASLVMTKAQLTEVQEAYETLLQKNQGILSAAHEALLKQVNELRAELKEESKKAVSLKSQLEDVSILQMTLKEFQERVEDLEKERKLLNDNYDKLLESMLDSSDSSSQPHWSNELIAEQLQQQVSQLQDQLDAELEDKRKVLLELSREKAQNEDLKLEVTNILQKHKQEVELLQNAATISQPPDRQSEPATHPAVLQENTQIEPSEPKNQEEKKLSQVLNELQVSHAETTLELEKTRDMLILQRKINVCYQEELEAMMTKADNDNRDHKEKLERLTRLLDLKNNRIKQLEGILRSHDLPTSEQLKDVAYGTRPLSLCLETLPAHGDEDKVDISLLHQGENLFELHIHQAFLTSAALAQAGDTQPTTFCTYSFYDFETHCTPLSVGPQPLYDFTSQYVMETDSLFLHYLQEASARLDIHQAMASEHSTLAAGWICFDRVLETVEKVHGLATLIGAGGEEFGVLEYWMRLRFPIKPSLQACNKRKKAQVYLSTDVLGGRKAQEEEFRSESWEPQNELWIEITKCCGLRSRWLGTQPSPYAVYRFFTFSDHDTAIIPASNNPYFRDQARFPVLVTSDLDHYLRREALSIHVFDDEDLEPGSYLGRARVPLLPLAKNESIKGDFNLTDPAEKPNGSIQVQLDWKFPYIPPESFLKPEAQTKGKDTKDSSKISSEEEKASFPSQDQMASPEVPIEAGQYRSKRKPPHGGERKEKEHQVVSYSRRKHGKRIGVQGKNRMEYLSLNILNGNTPEQVNYTEWKFSETNSFIGDGFKNQHEEEEMTLSHSALKQKEPLHPVNDKESSEQGSEVSEAQTTDSDDVIVPPMSQKYPKADSEKMCIEIVSLAFYPEAEVMSDENIKQVYVEYKFYDLPLSETETPVSLRKPRAGEEIHFHFSKVIDLDPQEQQGRRRFLFDMLNGQDPDQGHLKFTVVSDPLDEEKKECEEVGYAYLQLWQILESGRDILEQELDIVSPEDLATPIGRLKVSLQAAAVLHAIYKEMTEDLFS"},{"id":"SEQ_05465","a":"P54259","g":"ATN1","d":"Atrophin-1","L":1190,"m":[{"c":"x[YF]+[TPG][GAT][ST]P[PT]","u":8,"sp":"tandem","x":"disordered_like","cf":"high","why":"Six 8-residue copies in a Pro/Ser/Gly-rich disordered region (residues 628-692) share an invariant aromatic-basic dyad ([YF]+) followed by small/turn residues and a conserved [ST]P[PT] C-terminus. The central four copies occur in a strict head-to-tail tandem array, flanked by two copies separated by short 13-aa (containing a degenerate PYGKRAPSP variant) and 4-aa linkers.","i":[[627,634,"GYKTASPP"],[648,655,"AYKTATPP"],[656,663,"GYKPGSPP"],[664,671,"SFRTGTPP"],[672,679,"GYRGTSPP"],[684,691,"TFKPGSPT"]]}],"s":"MKTRQNKDSMSMRSGRKKEAPGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKEREREREREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGGLALQPGPPGLHPFPFHPSLGPLERERLALAAGPALRPDMSYAERLAAERQHAERVAALGNDPLARLQMLNVTPHHHQHSHIHSHLHLHQQDAIHAASASVHPLIDPLASGSHLTRIPYPAGTLPNPLLPHPLHENEVLRHQLFAAPYRDLPASLSAPMSAAHQLQAMHAQSAELQRLALEQQQWLHAHHPLHSVPLPAQEDYYSHLKKESDKPL"},{"id":"SEQ_05468","a":"Q9ULV3","g":"CIZ1","d":"Cip1-interacting zinc finger protein","L":898,"m":[{"c":"φCxxC(x){10,13}HxxxxxH","u":"22-25","sp":"dispersed","x":"structured_like","cf":"high","why":"Four dispersed C2H2-type coordination repeats anchored by an N-terminal hydrophobic residue preceding a CxxC pair and an invariant C-terminal HxxxxxH motif separated by a 10-13 residue loop.","i":[[594,617,"FCYICKASCSSQQEFQDHMSEPQH"],[655,676,"WCNTCQLYYMGDLIQHRRTQDH"],[686,709,"FCTVCNRYFKTPRKFVEHVKSQGH"],[800,824,"ICRICHKFYHSNSGAQLSHCKSLGH"]]},{"c":"QLQQEAEP[QL]KQVQPQVQPQAHSQ[GP]PRQV","u":28,"sp":"tandem","x":"disordered_like","cf":"high","why":"Head-to-tail 28-residue tandem duplication within the central Q/P/V-rich disordered region sharing 26 of 28 identical positions across both copies.","i":[[364,391,"QLQQEAEPQKQVQPQVQPQAHSQGPRQV"],[392,419,"QLQQEAEPLKQVQPQVQPQAHSQPPRQV"]]}],"s":"MFSQQQQQQLQQQQQQLQQLQQQQLQQQQLQQQQLLQLQQLLQQSPPQAPLPMAVSRGLPPQQPQQPLLNLQGTNSASLLNGSMLQRALLLQQLQGLDQFAMPPATYDTAGLTMPTATLGNLRGYGMASPGLAAPSLTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSQFNLSGRNPQKQARTSSSTTPNRKDSSSQTMPVEDKSDPPEGSEEAAEPRMDTPEDQDLPPCPEDIAKEKRTPAPEPEPCEASELPAKRLRSSEEPTEKEPPGQLQVKAQPQARMTVPKQTQTPDLLPEALEAQVLPRFQPRVLQVQAQVQSQTQPRIPSTDTQVQPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAEPQKQVQPQVQPQAHSQGPRQVQLQQEAEPLKQVQPQVQPQAHSQPPRQVQLQLQKQVQTQTYPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHTQPQVSLLAPEQTPVVVHVCGLEMPPDAVEAGGGMEKTLPEPVGTQVSMEEIQNESACGLDVGECENRAREMPGVWGAGGSLKVTILQSSDSRAFSTVPLTPVPRPSDSVSSTPAATSTPSKQALQFFCYICKASCSSQQEFQDHMSEPQHQQRLGEIQHMSQACLLSLLPVPRDVLETEDEEPPPRRWCNTCQLYYMGDLIQHRRTQDHKIAKQSLRPFCTVCNRYFKTPRKFVEHVKSQGHKDKAKELKSLEKEIAGQDEDHFITVDAVGCFEGDEEEEEDDEDEEEIEVEEELCKQVRSRDISREEWKGSETYSPNTAYGVDFLVPVMGYICRICHKFYHSNSGAQLSHCKSLGHFENLQKYKAAKNPSPTTRPVSRRCAINARNALTALFTSSGRPPSQPNTQDKTPSKVTARPSQPPLPRRSTRLKT"},{"id":"SEQ_05489","a":"A8CG34","g":"POM121C","d":"Nuclear envelope pore membrane protein POM 121C","L":1229,"m":[{"c":"xFxFG","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Eight dispersed 5-residue repeats in the C-terminal S/T/P/A-rich disordered region anchored by invariant F at positions 2 and 4 and C-terminal G, preceded by small or aliphatic uncharged residues.","i":[[680,684,"SFLFG"],[812,816,"AFGFG"],[838,842,"PFLFG"],[858,862,"IFQFG"],[971,975,"SFTFG"],[1042,1046,"VFSFG"],[1076,1080,"PFTFG"],[1106,1110,"AFSFG"]]},{"c":"[QTK]PxFG","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Six non-overlapping dispersed FG-family repeats in the C-terminal disordered region distinguished by a conserved P at position 2, a constrained polar/basic [QTK] anchor at position 1, and small/aliphatic residues [ASTV] before the invariant FG dipeptide.","i":[[946,950,"QPAFG"],[965,969,"TPSFG"],[1006,1010,"QPTFG"],[1033,1037,"QPAFG"],[1152,1156,"KPVFG"],[1160,1164,"TPTFG"]]}],"s":"MSPAAAAAGAGERRRPIASVRDGRGRGCGGPAGAALLGLSLVGLLLYLVPAAAALAWLAVGTTAAWWGLSREPRGSRPLSSFVQKARHRRTLFASPPAKSTANGNLLEPRTLLEGPDPAELLLMGSYLGKPGPPQPAPAPEGQDLRNRPGRRPPARPAPRSTPPSQPTHRVHHFYPSLPTPLLRPSGRPSPRDRGTLPDRFVITPRRRYPIHQTQYSCPGVLPTVCWNGYHKKAVLSPRNSRMVCSPVTVRIAPPDRRFSRSAIPEQIISSTLSSPSSNAPDPCAKETVLSALKEKKKKRTVEEEDQIFLDGQENKRRRHDSSGSGHSAFEPLVASGVPASFVPKPGSLKRGLNSQSSDDHLNKRSRSSSMSSLTGAYTSGIPSSSRNAITSSYSSTRGISQLWKRNGPSSSPFSSPASSRSQTPERPAKKIREEELCHHSSSSTPLAADKESQGEKAADTTPRKKQNSNSQSTPGSSGQRKRKVQLLPSRRGEQLTLPPPPQLGYSITAEDLDLEKKASLQWFNQALEDKSDAASNSVTETPPTTQPSFTFTLPAAATASPPTSLLAPSTNPLLESLKKMQTPPSLPPCPESAGAATTEALSPPKTPSLLPPLGLSQSGPPGLLPSPSFDSKPPTTLLGLIPAPSMVPATDTKAPPTLQAETATKPQATSAPSPAPKQSFLFGTQNTSPSSPAAPAASSASPMFKPIFTAPPKSEKEGLTPPGPSVSATAPSSSSLPTTTSTTAPTFQPVFSSMGPPASVPLPAPFFKQTTTPATAPTTTAPLFTGLASATSAVAPITSASPSTDSASKPAFGFGINSVSSSSVSTTTSTATAASQPFLFGAPQASAASFTPAMGSIFQFGKPPALPTTTTVTTFSQSLPTAVPTATSSSAADFSGFGSTLATSAPATSSQPTLTFSNTSTPTFNIPFGSSAKSPLPSYPGANPQPAFGAAEGQPPGAAKPALTPSFGSSFTFGNSAAPAPATAPTPAPASTIKIVPAHVPTPIQPTFGGATHSAFGLKATASAFGAPASSQPAFGGSTAVFSFGAATSSGFGATTQTASSGSSSSVFGSTTPSPFTFGGSAAPAGSGSFGINVATPGSSATTGAFSFGAGQSGSTATSTPFTGGLGQNALGTTGQSTPFAFNVGSTTESKPVFGGTATPTFGQNTPAPGVGTSGSSLSFGASSAPAQGFVGVGPFGSAAPSFSIGAGSKTPGARQRLQARRQHTRKK"},{"id":"SEQ_05496","a":"A6NJ64","g":"NPIPB2","d":"Nuclear pore complex-interacting protein family member B2","L":397,"m":[{"c":"[KS]PP[EK]PKR[WR]RAAE[MV]E","u":14,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three head-to-tail 14-residue repeats in the C-terminal disordered region with 10 invariant anchors (PPxPKRxRAAExE) and 4 tightly constrained 2-residue positions, followed immediately by a fourth C-terminally truncated copy (PSSPEPKRRR).","i":[[334,347,"KPPKPKRWRAAEME"],[348,361,"SPPEPKRRRAAEVE"],[362,375,"SPPEPKRRRAAEVE"]]},{"c":"LKTPPECLLTPLPPSA","u":16,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Two non-overlapping 16-residue copies with 100% sequence identity across all positions (including fixed P, C, and L anchors) separated by a 3-residue DDN linker in the C-terminal proline-rich region, followed by a partial PPSADDNLKTPPL remnant.","i":[[278,293,"LKTPPECLLTPLPPSA"],[297,312,"LKTPPECLLTPLPPSA"]]}],"s":"MFCCLGYEWLSGGCKTWHSAWVINTLADHHHRGTDFGGSPWLRIIIAFPRSYKVVLTLWTVYLWLSFLKTIFQSENGHDVSTDVQQRARRSNRRRQEGLRSICMHTKKRVSSFPGNKIGLKDVITLRRHVETKGRAKIRKMKVTTKINHHDKINGKRKTAKKQKLSVKECEHAEKERQVSEAEENGKLDMKEIHTYMKMFQRAQELRRRAEDYHKCKIPPSARKALCNWVRMAAAEHRHSSGLPYWPYLTAETLKNRMGHQPPPPTQQHSITDNSLSLKTPPECLLTPLPPSADDNLKTPPECLLTPLPPSAPPSADDNLKTPPLATQEAEAEKPPKPKRWRAAEMESPPEPKRRRAAEVESPPEPKRRRAAEVEPSSPEPKRRRLSKLRTGHCTQA"},{"id":"SEQ_05501","a":"Q9ULJ6","g":"ZMIZ1","d":"Zinc finger MIZ domain-containing protein 1","L":1067,"m":[{"c":"[GN]NPM[AN]x[AG]","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three contiguous head-to-tail 7-residue repeats in the central disordered region anchored by an invariant NPM tripeptide core and flanked by conserved [GN], [AN], and [AG] positions.","i":[[183,189,"GNPMANA"],[190,196,"NNPMNPG"],[197,203,"GNPMASG"]]},{"c":"[DL]-LL[PS]x[LF]","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 7-residue motifs in the C-terminal acidic disordered tail sharing an invariant LL di-leucine core preceded by an acidic residue and [DL], and followed by [PS]x[LF].","i":[[1031,1037,"LDLLPEL"],[1041,1047,"DELLSYL"],[1058,1064,"DDLLSLF"]]}],"s":"MNSMDRHIQQTNDRLQCIKQHLQNPANFHNAATELLDWCGDPRAFQRPFEQSLMGCLTVVSRVAAQQGFDLDLGYRLLAVCAANRDKFTPKSAALLSSWCEELGRLLLLRHQKSRQSDPPGKLPMQPPLSSMSSMKPTLSHSDGSFPYDSVPWQQNTNQPPGSLSVVTTVWGVTNTSQSQVLGNPMANANNPMNPGGNPMASGMTTSNPGLNSPQFAGQQQQFSAKAGPAQPYIQQSMYGRPNYPGSGGFGASYPGGPNAPAGMGIPPHTRPPADFTQPAAAAAAAAVAAAAATATATATATVAALQETQNKDINQYGPMGPTQAYNSQFMNQPGPRGPASMGGSMNPASMAAGMTPSGMSGPPMGMNQPRPPGISPFGTHGQRMPQQTYPGPRPQSLPIQNIKRPYPGEPNYGNQQYGPNSQFPTQPGQYPAPNPPRPLTSPNYPGQRMPSQPSSGQYPPPTVNMGQYYKPEQFNGQNNTFSGSSYSNYSQGNVNRPPRPVPVANYPHSPVPGNPTPPMTPGSSIPPYLSPSQDVKPPFPPDIKPNMSALPPPPANHNDELRLTFPVRDGVVLEPFRLEHNLAVSNHVFHLRPTVHQTLMWRSDLELQFKCYHHEDRQMNTNWPASVQVSVNATPLTIERGDNKTSHKPLHLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVRSVLQGLLKKRLLPAEHCITKIKRNFSSVAASSGNTTLNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCKHVQCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMWGILNAIQHSEFEEVTIDPTCSWRPVPIKSDLHIKDDPDGIPSKRFKTMSPSQMIMPNVMEMIAALGPGPSPYPLPPPPGGTNSNDYSSQGNNYQGHGNFDFPHGNPGGTSMNDFMHGPPQLSHPPDMPNNMAALEKPLSHPMQETMPHAGSSDQPHPSIQQGLHVPHPSSQSGPPLHHSGAPPPPPSQPPRQPPQAAPSSHPHSDLTFNPSSALEGQAGAQGASDMPEPSLDLLPELTNPDELLSYLDPPDLPSNSNDDLLSLFENN"},{"id":"SEQ_05509","a":"Q9UKL0","g":"RCOR1","d":"REST corepressor 1","L":485,"m":[{"c":"WT[VT]E-xψLφxQAφxx[HY]G+xFxxIoxψψ[PG][DN]KSψφoψxxFΩφoΩ++","u":44,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two dispersed, ungapped 44-aa globular-like repeat units sharing 12 identical anchor residues (W, T, E, L, Q, A, G, F, I, K, S, F) and extensive hydrophobic/aliphatic core and C-terminal aromatic-basic conservation across >30 positions.","i":[[195,238,"WTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKK"],[386,429,"WTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRR"]]}],"s":"MPAMVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQKREREESEDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLDVRYASAS"},{"id":"SEQ_05527","a":"Q09472","g":"EP300","d":"Histone acetyltransferase p300","L":2414,"m":[{"c":"xxxxxxxxHxxxC(x){4,12}Cxψ(x){0,2}C","u":"21-31","sp":"dispersed","x":"structured_like","cf":"high","why":"Six copies of a 21-31 aa zinc-binding repeat organized into two duplicated 3-copy tandem arrays (N-terminal and C-terminal domains separated by ~1325 aa). Each unit features an 8-residue N-terminal segment followed by invariant HxxxC and Cxψ(x){0,2}C coordination motifs separated by a 4-12 residue loop.","i":[[339,369,"QQQLVLLLHAHKCQRREQANGEVRQCNLPHC"],[370,393,"RTMKNVLNHMTHCQSGKSCQVAHC"],[394,414,"ASSRQIISHWKNCTRHDCPVC"],[1736,1758,"QRCIQSLVHACQCRNANCSLPSC"],[1759,1782,"QKMKRVVQHTKGCKRKTNGGCPIC"],[1784,1806,"QLIALCCYHAKHCQENKCPVPFC"]]}],"s":"MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDINQLQTSLGMVQDAASKHKQLSELLRSGSSPNLNMGVGGPGQVMASQAQQSSPGLGLINSMVKSPMTQAGLTSPNMGMGTSGPNQGPTQSTGMMNSPVNQPAMGMNTGMNAGMNPGMLAAGNGQGIMPNQVMNGSIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQPLKMGMMNNPNPYGSPYTQNPGQQIGASGLGLQIQTKTVLSNNLSPFAMDKKAVPGGGMPNMGQQPAPQVQQPGLVTPVAQGMGSGAHTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKNAGDKRNQQPILTGAPVGLGNPSSLGVGQQSAPNLSTVSQIDPSSIERAYAALGLPYQVNQMPTQPQVQAKNQQNQQPGQSPQGMRPMSNMSASPMGVNGGVGVQTPSLLSDSMLHSAINSQNPMMSENASVPSLGPMPTAAQPSTTGIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKRRTRLQKQNMLPNAAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPSMIRGSVPNQMMPRITPQSGLNQFGQMSMAQPPIVPRQTPPLQHHGQLAQPGALNPPMGYGPRMQQPSNQGQFLPQTQFPSQGMNVTNIPLAPSSGQAPVSQAQMSSSSCPVNSPIMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIGAQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPSLPAAPSADQPQQQPRSQQSTAASVPTPTAPLLPPQPATPLSQPAVSIEGQVSNPPSTSSTEVNSQAIAEKQPSQEVKMEAKMEVDQPEPADTQPEDISESKVEDCKMESTETEERSTELKTEIKEEEDQPSTSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAKKKNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVYTCNECKHHVETRWHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDESNNQQAAATQSPGDSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENKCPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVGQQQGLPSPTPATPTTPTGQQPTTPQTPQPTSQPQPTPPNSMPPYLPRTQAAGPVSQGKAAGQVTPPTPPQTAQPPLPGPPPAAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQMPPMTPMAPMGMNPPPMTRGPSGHLEPGMGPTGMQQQPPWSQGGLPQPQQLQSGMPRPAMMSVAQHGQPLNMAPQPGLGQVGISPLKPGTVSQQALQNLLRTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYANSNPQPIPGQPGMPQGQPGLQPPTMPGQQGVHSNPAMQNMNPMQAGVQRAGLPQQQPQQQLQPPMGGMSPQAQQMNMNHNTMPSQFRDILRRQQMMQQQQQQGAGPGIGPGMANHNQFQQPQGVGYPPQQQQRMQHHMQQMQQGNMGQIGQLPQALGAEAGASLQAYQQRLLQQQMGSPVQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQVRSPQPVPSPRPQSQPPHSSPSPRMQPQPSPHHVSPQTSSPHPGLVAAQANPMEQGHFASPDQNSMLSQLASNPGMANLHGASATDLGLSTDNSDLNSNLSQSTLDIH"},{"id":"SEQ_05529","a":"Q13342","g":"SP140","d":"Nuclear body protein SP140","L":867,"m":[{"c":"ETFDLKTPQVTNEGEPEK[GE]L[CS]LLPGEGEEGSDDCSEMCDGEE[PR]QEASSSLAR[CR]GSVS[CS]xxx","u":61,"sp":"tandem","x":"disordered_like","cf":"high","why":"Head-to-tail 61-aa tandem duplication in the central acidic/polar disordered region sharing 53/61 identical positions across the two copies, including conserved ETFDLKTPQVTNEGEPEK, LLPGEGEEGSDDCSEMCDGEE, and QEASSSLARxGSVS blocks.","i":[[298,358,"ETFDLKTPQVTNEGEPEKGLCLLPGEGEEGSDDCSEMCDGEEPQEASSSLARCGSVSCLSA"],[359,419,"ETFDLKTPQVTNEGEPEKELSLLPGEGEEGSDDCSEMCDGEERQEASSSLARRGSVSSELE"]]},{"c":"E-xPxLLP[GY]","u":9,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 9-aa copies in the disordered segment upstream of the 61-aa tandem duplication, anchored by an N-terminal acidic dyad (ED/EE), fixed P4 and LLP6-8 core, and C-terminal Y/G.","i":[[152,160,"EDRPRLLPY"],[211,219,"EDAPSLLPG"],[236,244,"EEMPKLLPY"]]}],"s":"MAQQGQQGQMASGDSNLNFRMVAEIQNVEGQNLQEQVCPEPIFRFFRENKVEIASAITRPFPFLMGLRDRSFISEQMYEHFQEAFRNLVPVTRVMYCVLSELEKTFGWSHLEALFSRINLMAYPDLNEIYRSFQNVCYEHSPLQMNNVNDLEDRPRLLPYGKQENSNACHEMDDIAVPQEALSSSPRCEPGFSSESCEQLALPKAGGGDAEDAPSLLPGGGVSCKLAIQIDEGESEEMPKLLPYDTEVLESNGMIDAARTYSTAPGEKQGEEEGRNSPRKRNQDKEKYQESPEGRDKETFDLKTPQVTNEGEPEKGLCLLPGEGEEGSDDCSEMCDGEEPQEASSSLARCGSVSCLSAETFDLKTPQVTNEGEPEKELSLLPGEGEEGSDDCSEMCDGEERQEASSSLARRGSVSSELENHPMNEEGESEELASSLLYDNVPGAEQSAYENEKCSCVMCFSEEVPGSPEARTESDQACGTMDTVDIANNSTLGKPKRKRRKKRGHGWSRMRMRRQENSQQNDNSKADGQVVSSEKKANVNLKDLSKIRGRKRGKPGTRFTQSDRAAQKRVRSRASRKHKDETVDFKAPLLPVTCGGVKGILHKKKLQQGILVKCIQTEDGKWFTPTEFEIKGGHARSKNWRLSVRCGGWPLRWLMENGFLPDPPRIRYRKKKRILKSQNNSSVDPCMRNLDECEVCRDGGELFCCDTCSRVFHEDCHIPPVEAERTPWNCIFCRMKESPGSQQCCQESEVLERQMCPEEQLKCEFLLLKVYCCSESSFFAKIPYYYYIREACQGLKEPMWLDKIKKRLNEHGYPQVEGFVQDMRLIFQNHRASYKYKDFGQMGFRLEAEFEKNFKEVFAIQETNGNN"},{"id":"SEQ_05553","a":"Q13243","g":"SRSF5","d":"Serine/arginine-rich splicing factor 5","L":272,"m":[{"c":"RψφψxxLoxxφxxxDψxxFφ+xφGxψxxφDφ[KH]R(x){4,7}VEFxxxxDφx[DN]AψxxL[DS]GKEψ(x){6,7}IE","u":"66-70","sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 66-70 aa structured-like repeats separated by a 38 aa R/G/S-rich linker, anchored by fixed R, L, D, F, G, D, [KH]R, VEF, D, A, L[DS]GKE, and C-terminal IE positions plus conserved hydrophobic core registers throughout both copies (flanking RGRG and C-terminal SRSR runs are unanchored low-complexity tracts).","i":[[5,70,"RVFIGRLNPAAREKDVERFFKGYGRIRDIDLKRGFGFVEFEDPRDADDAVYELDGKELCSERVTIE"],[109,178,"RLIVENLSSRVSWQDLKDFMRQAGEVTFADAHRPKLNEGVVEFASYGDLKNAIEKLSGKEINGRKIKLIE"]]}],"s":"MSGCRVFIGRLNPAAREKDVERFFKGYGRIRDIDLKRGFGFVEFEDPRDADDAVYELDGKELCSERVTIEHARARSRGGRGRGRYSDRFSSRRPRNDRRNAPPVRTENRLIVENLSSRVSWQDLKDFMRQAGEVTFADAHRPKLNEGVVEFASYGDLKNAIEKLSGKEINGRKIKLIEGSKRHSRSRSRSRSRTRSSSRSRSRSRSRSRKSYSRSRSRSRSRSRSKSRSVSRSPVPEKSQKRGSSSRSKSPASVDRQRSRSRSRSRSVDSGN"},{"id":"SEQ_05556","a":"Q8ND23","g":"CARMIL3","d":"Capping protein, Arp2/3 and myosin-I linker protein 3","L":1372,"m":[{"c":"Lxxψxφxxo(x){18,25}","u":"27-34","sp":"tandem","x":"structured_like","cf":"high","why":"Head-to-tail tandem array of 13 structured 27-34 aa units (residues 245-626), each anchored by a conserved hydrophobic-polar beta-turn core (Lxxψxφxx[NTSC]) followed by an amphipathic alpha-helical segment of alternating length.","i":[[245,274,"LEELVLDNAGLKTDFVQKLAGVFGENGSCV"],[275,303,"LHALTLSHNPIEDKGFLSLSQQLLCFPSG"],[304,335,"LTKLCLAKTAISPRGLQALGQTFGANPAFASS"],[336,365,"LRYLDLSKNPGLLATDEANALYSFLAQPNA"],[366,392,"LVHLDLSGTDCVIDLLLGALLHGCCSH"],[393,424,"LTYLNLARNSCSHRKGREAPPAFKQFFSSAYT"],[425,454,"LSHVNLSATKLPLEALRALLQGLSLNSHLS"],[455,482,"DLHLDLSSCELRSAGAQALQEQLGAVTC"],[483,509,"VGSLDLSDNGFDSDLLTLVPALGKNKS"],[510,543,"LKHLFLGKNFNVKAKTLEEILHKLVQLIQEEDCS"],[544,570,"LQSLSVADSRLKLRTSILINALGSNTC"],[571,598,"LAKVDLSGNGMEDIGAKMLSKALQINSS"],[599,626,"LRTILWDRNNTSALGFLDIARALESNHT"]]}],"s":"MAKPSVELTRELQDSIRRCLSQGAVLQQHHVKLETKPKKFEDRVLALTSWRLHLFLLKVPAKVESSFNVLEIRAFNTLSQNQILVETERGMVSMRLPSAESVDQVTRHVSSALSKVCPGPGCLIRRGNADTPEGPRDTSPNSETSTSTTHSVCGGFSETYAALCDYNGLHCREEVQWDVDTIYHAEDNREFNLLDFSHLESRDLALMVAALAYNQWFTKLYCKDLRLGSEVLEQVLHTLSKSGSLEELVLDNAGLKTDFVQKLAGVFGENGSCVLHALTLSHNPIEDKGFLSLSQQLLCFPSGLTKLCLAKTAISPRGLQALGQTFGANPAFASSLRYLDLSKNPGLLATDEANALYSFLAQPNALVHLDLSGTDCVIDLLLGALLHGCCSHLTYLNLARNSCSHRKGREAPPAFKQFFSSAYTLSHVNLSATKLPLEALRALLQGLSLNSHLSDLHLDLSSCELRSAGAQALQEQLGAVTCVGSLDLSDNGFDSDLLTLVPALGKNKSLKHLFLGKNFNVKAKTLEEILHKLVQLIQEEDCSLQSLSVADSRLKLRTSILINALGSNTCLAKVDLSGNGMEDIGAKMLSKALQINSSLRTILWDRNNTSALGFLDIARALESNHTLRFMSFPVSDISQAYRSAPERTEDVWQKIQWCLVRNNHSQTCPQEQAFRLQQGLVTSSAEQMLQRLCGRVQEEVRALRLCPLEPVQDELLYARDLIKDAKNSRALFPSLYELGHVLANDGPVRQRLESVASEVSKAVDKELQVILESMVSLTQELCPVAMRVAEGHNKMLSNVAERVTVPRNFIRGALLEQAGQDIQNKLDEVKLSVVTYLTSSIVDEILQELYHSHKSLARHLTQLRTLSDPPGCPGQGQDLSSRGRGRNHDHEETTDDELGTNIDTMAIKKQKRCRKIRPVSAFISGSPQDMESQLGNLGIPPGWFSGLGGSQPTASGSWEGLSELPTHGYKLRHQTQGRPRPPRTTPPGPGRPSMPAPGTRQENGMATRLDEGLEDFFSRRVLEESSSYPRTLRTVRPGLSEAPLPPLQKKRRRGLFHFRRPRSFKGDRGPGSPTTGLLLPPPPPPPPTQESPPSPDPPSLGNNSSPCWSPEEESSLLPGFGGGRGPSFRRKMGTEGSEPGEGGPAPGTAQQPRVHGVALPGLERAKGWSFDGKREGPGPDQEGSTQAWQKRRSSDDAGPGSWKPPPPPQSTKPSFSAMRRAEATWHIAEESAPNHSCQSPSPASQDGEEEKEGTLFPERTLPARNAKLQDPALAPWPPKPVAVPRGRQPPQEPGVREEAEAGDAAPGVNKPRLRLSSQQDQEEPEVQGPPDPGRRTAPLKPKRTRRAQSCDKLEPDRRRPPDPTGTSEPGTD"},{"id":"SEQ_05570","a":"O43296","g":"ZNF264","d":"Zinc finger protein 264","L":627,"m":[{"c":"[FY][EKV]CxECG[KQ]xFxxxxx[LF]xxHxxxH[ST]G[EKV][KRN][PS]","u":28,"sp":"tandem","x":"structured_like","cf":"high","why":"Contiguous head-to-tail tandem array of 13 28-residue repeats defined by invariant C-x2-C-G, F, and H-x3-H structural anchors, a conserved [LF] core position, and a conserved [ST]G[EKV][KRN][PS] linker.","i":[[203,230,"FKCSECGKVFNKKHLLAGHEKIHSGVKP"],[231,258,"YECTECGKTFIKSTHLLQHHMIHTGERP"],[259,286,"YECMECGKAFNRKSYLTQHQRIHSGEKP"],[287,314,"YKCNECGKAFTHRSNFVLHNRRHTGEKS"],[315,342,"FVCTECGQVFRHRPGFLRHYVVHSGENP"],[343,370,"YECLECGKVFKHRSYLMWHQQTHTGEKP"],[371,398,"YECSECGKVFLESAALIHHYVIHTGEKP"],[399,426,"FECLECGKAFNHRSYLKRHQRIHTGEKP"],[427,454,"FVCSECGKAFTHCSTFILHKRAHTGEKP"],[455,482,"FECKECGKAFSNRKDLIRHFSIHTGEKP"],[483,510,"YECVECGKAFTRMSGLTRHKRIHSGEKP"],[511,538,"YECVECGKSFCWSTNLIRHAIIHTGEKP"],[539,566,"YKCSECGKAFSRSSSLTQHQRMHTGKNP"]]}],"s":"MAAAVLTDRAQVSVTFDDVAVTFTKEEWGQLDLAQRTLYQEVMLENCGLLVSLGCPVPKAELICHLEHGQEPWTRKEDLSQDTCPGDKGKPKTTEPTTCEPALSEGISLQGQVTQGNSVDSQLGQAEDQDGLSEMQEGHFRPGIDPQEKSPGKMSPECDGLGTADGVCSRIGQEQVSPGDRVRSHNSCESGKDPMIQEEENNFKCSECGKVFNKKHLLAGHEKIHSGVKPYECTECGKTFIKSTHLLQHHMIHTGERPYECMECGKAFNRKSYLTQHQRIHSGEKPYKCNECGKAFTHRSNFVLHNRRHTGEKSFVCTECGQVFRHRPGFLRHYVVHSGENPYECLECGKVFKHRSYLMWHQQTHTGEKPYECSECGKVFLESAALIHHYVIHTGEKPFECLECGKAFNHRSYLKRHQRIHTGEKPFVCSECGKAFTHCSTFILHKRAHTGEKPFECKECGKAFSNRKDLIRHFSIHTGEKPYECVECGKAFTRMSGLTRHKRIHSGEKPYECVECGKSFCWSTNLIRHAIIHTGEKPYKCSECGKAFSRSSSLTQHQRMHTGKNPISVTDVGRPFTSGQTSVTLRELLLGKDFLNVTTEANILPEETSSSASDQPYQRETPQVSSL"},{"id":"SEQ_05572","a":"Q12967","g":"RALGDS","d":"Ral guanine nucleotide dissociation stimulator","L":914,"m":[{"c":"[EG]L[EQ]xAP[AE][PQ][ADV][PVL]","u":10,"sp":"tandem","x":"disordered_like","cf":"high","why":"Five 10-residue repeats in the central proline/glutamate-rich disordered linker (four contiguous head-to-tail copies followed by a fifth after a 6-residue gap), anchored by an invariant L at position 2 within an [EG]L[EQ] cap and an invariant AP dipeptide followed by [AE][PQ].","i":[[304,313,"ELEVAPAPAP"],[314,323,"ELQQAPEPAV"],[324,333,"GLESAPAPAL"],[334,343,"ELEPAPEQDP"],[350,359,"ELEPAPAPVP"]]}],"s":"MVQRMWAEAAGPAGGAEPLFPGSRRSRSVWDAVRLEVGVPDSCPVVLHSFTQLDPDLPRPESSTQEIGEELINGVIYSISLRKVQLHHGGNKGQRWLGYENESALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYGCILPYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEHSEPIEAEPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAPSTELSTSGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQEKKFWESASQSSPETSGISSASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQVGDCCIIRVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDKHNLEEEEPEDYELLQILSDDRKLKIPENANVFYAMNSTANYDFVLKKRTFTKGVKVKHGASSTLPRMKQKGLKIAKGIF"},{"id":"SEQ_05587","a":"Q9UPV0","g":"CEP164","d":"Centrosomal protein of 164 kDa","L":1460,"m":[{"c":"ExEψψxφARExxψxPψ","u":16,"sp":"tandem","x":"structured_like","cf":"medium","why":"Head-to-tail 16-aa N-terminal duplication separated by a 1-residue linker (K), sharing 6 identical anchor positions (E1, E3, A8, R9, E10, P15) and 5 conserved hydrophobic/aliphatic positions (ψ4, ψ5, φ7, ψ13, ψ16). Separately, residues ~590-1200 form an extended amphipathic coiled-coil heptad domain.","i":[[26,41,"EQEILEFAREIGIDPI"],[43,58,"EPELMWLAREGIVAPL"]]}],"s":"MAGRPLRIGDQLVLEEDYDETYIPSEQEILEFAREIGIDPIKEPELMWLAREGIVAPLPGEWKPCQDITGDIYYFNFANGQSMWDHPCDEHYRSLVIQERAKLSTSGAIKKKKKKKEKKDKKDRDPPKSSLALGSSLAPVHVPLGGLAPLRGLVDTPPSALRGSQSVSLGSSVESGRQLGELMLPSQGLKTSAYTKGLLGSIYEDKTALSLLGLGEETNEEDEEESDNQSVHSSSEPLRNLHLDIGALGGDFEYEESLRTSQPEEKKDVSLDSDAAGPPTPCKPSSPGADSSLSSAVGKGRQGSGARPGLPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTLGGSPTKKAVTFDLSDMDSLSSESSESFSPPHREWWRQQRIDSTPSLTSRKIHGLSHSLRQISSQLSSVLSILDSLNPQSPPPLLASMPAQLPPRDPKSTPTPTYYGSLARFSALSSATPTSTQWAWDSGQGPRLPSSVAQTVDDFLLEKWRKYFPSGIPLLSNSPTPLESRLGYMSASEQLRLLQHSHSQVPEAGSTTFQGIIEANRRWLERVKNDPRLPLFSSTPKPKATLSLLQLGLDEHNRVKVYRF"},{"id":"SEQ_05589","a":"P10636","g":"MAPT","d":"Microtubule-associated protein tau","L":758,"m":[{"c":"D[LF](x){2,3}VxSK[IC]GSxxN[IL]xHxPGGGx[VK]x[IV]xxx[KP][LV]","u":"31-32","sp":"tandem","x":"disordered_like","cf":"high","why":"Four contiguous head-to-tail 31-32 aa repeats in the C-terminal half anchored by invariant D1, V, SK[IC]GS, N[IL]xHxPGGG, and conserved C-terminal aliphatic/basic positions, with a 1-residue turn insertion in the fourth copy.","i":[[569,599,"DLKNVKSKIGSTENLKHQPGGGKVQIINKKL"],[600,630,"DLSNVQSKCGSKDNIKHVPGGGSVQIVYKPV"],[631,661,"DLSKVTSKCGSLGNIHHKPGGGQVEVKSEKL"],[662,693,"DFKDRVQSKIGSLDNITHVPGGGNKKIETHKL"]]}],"s":"MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEGGRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL"},{"id":"SEQ_05605","a":"Q9UL54","g":"TAOK2","d":"Serine/threonine-protein kinase TAO2","L":1235,"m":[{"c":"[DEQ][QR]R[IM]LG[EK]E","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three closely clustered 8-aa copies in the P/E/G/S-rich disordered region (residues 785-820) share four invariant anchors (R, L, G, E) and four tightly constrained positions ([DEQ], [QR], [IM], [EK]), separated by 5-7 aa linkers.","i":[[785,792,"DQRMLGEE"],[798,805,"ERRILGKE"],[813,820,"QQRILGEE"]]}],"s":"MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGPPNTGTPIEQQPCSPGQEAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQRILGEESGAPSPSPQKHGSLVDEEVWGLPEEIEELRVPSLVPQERSIVGQEEAGTWSLWGKEDESLLDEEFELGWVQGPALTPVPEEEEEEEEGAPIGTPRDPGDGCPSPDIPPEPPPTHLRPCPASQLPGLLSHGLLAGLSFAVGSSSGLLPLLLLLLLPLLAAQGGGGLQAALLALEVGLVGLGASYLLLCTALHLPSSLFLLLAQGTALGAVLGLSWRRGLMGVPLGLGAAWLLAWPGLALPLVAMAAGGRWVRQQGPRVRRGISRLWLRVLLRLSPMAFRALQGCGAVGDRGLFALYPKTNKDGFRSRLPVPGPRRRNPRTTQHPLALLARVWVLCKGWNWRLARASQGLASHLPPWAIHTLASWGLLRGERPTRIPRLLPRSQRQLGPPASRQPLPGTLAGRRSRTRQSRALPPWR"},{"id":"SEQ_05609","a":"O94916","g":"NFAT5","d":"Nuclear factor of activated T-cells 5","L":1531,"m":[{"c":"oxxφ[FY]x[SPQ][QP]xxψxxφQ","u":15,"sp":"dispersed","x":"disordered_like","cf":"high","why":"17 dispersed-to-quasi-periodic 15-aa motif copies across the Q/P/S-rich C-terminal disordered region, anchored by an invariant aromatic [FY] at position 5, an invariant large aliphatic ψ (I/M/V/L) at position 11, strongly conserved hydrophobic positions 4 and 14, and flanking polar/Q caps at positions 1, 7-8, and 15.","i":[[758,772,"SSNIFPSPNSVSQLQ"],[1020,1034,"QVNLFSSTKSMMSVQ"],[1042,1056,"GNGLFQQGNEMMSLQ"],[1068,1082,"QAQLFHPQNPIADAQ"],[1089,1103,"QGSLFHSPNPIVHSQ"],[1113,1127,"QPPMFHSQSTIAVLQ"],[1137,1151,"STNIFLSQSPMNNLQ"],[1157,1171,"QEAFFAAPNSISPLQ"],[1178,1192,"QQAAFQQQAPISHIQ"],[1205,1219,"QQGLFQPQVALGSLP"],[1228,1242,"QGTMFQSQHSIVAMQ"],[1266,1280,"QSILFSNQNTMATMA"],[1305,1319,"NQSIFHQQSNMAPMN"],[1323,1337,"QPMQFQSQSTVSSLQ"],[1348,1362,"QTPLFHSSPQIQLVQ"],[1371,1385,"QVTLFLSPASMSALQ"],[1395,1409,"QSPLYSPQNNMPGIQ"]]}],"s":"MPSDFISLLSADLDLESPKSLYSRESVYDLLPKELQLPPSRETSVASMSQTSGGEAGSPPPAVVAADASSAPSSSSMGGACSSFTTSSSPTIYSTSVTDSKAMQVESCSSAVGVSNRGVSEKQLTSNTVQQHPSTPKRHTVLYISPPPEDLLDNSRMSCQDEGCGLESEQSCSMWMEDSPSNFSNMSTSSYNDNTEVPRKSRKRNPKQRPGVKRRDCEESNMDIFDADSAKAPHYVLSQLTTDNKGNSKAGNGTLENQKGTGVKKSPMLCGQYPVKSEGKELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGHNEPVVLQVFVGNDSGRVKPHGFYQACRVTGRNTTPCKEVDIEGTTVIEVGLDPSNNMTLAVDCVGILKLRNADVEARIGIAGSKKKSTRARLVFRVNIMRKDGSTLTLQTPSSPILCTQPAGVPEILKKSLHSCSVKGEEEVFLIGKNFLKGTKVIFQENVSDENSWKSEAEIDMELFHQNHLIVKVPPYHDQHITLPVSVGIYVVTNAGRSHDVQPFTYTPDPAAAGALNVNVKKEISSPARPCSFEEAMKAMKTTGCNLDKVNIIPNALMTPLIPSSMIKSEDVTPMEVTAEKRSSTIFKTTKSVGSTQQTLENISNIAGNGSFSSPSSSHLPSENEKQQQIQPKAYNPETLTTIQTQDISQPGTFPAVSASSQLPNSDALLQQATQFQTRETQSREILQSDGTVVNLSQLTEASQQQQQSPLQEQAQTLQQQISSNIFPSPNSVSQLQNTIQQLQAGSFTGSTASGSSGSVDLVQQVLEAQQQLSSVLFSAPDGNENVQEQLSADIFQQVSQIQSGVSPGMFSSTEPTVHTRPDNLLPGRAESVHPQSENTLSNQQQQQQQQQQVMESSAAMVMEMQQSICQAAAQIQSELFPSTASANGNLQQSPVYQQTSHMMSALSTNEDMQMQCELFSSPPAVSGNETSTTTTQQVATPGTTMFQTSSSGDGEETGTQAKQIQNSVFQTMVQMQHSGDNQPQVNLFSSTKSMMSVQNSGTQQQGNGLFQQGNEMMSLQSGNFLQQSSHSQAQLFHPQNPIADAQNLSQETQGSLFHSPNPIVHSQTSTTSSEQMQPPMFHSQSTIAVLQGSSVPQDQQSTNIFLSQSPMNNLQTNTVAQEAFFAAPNSISPLQSTSNSEQQAAFQQQAPISHIQTPMLSQEQAQPPQQGLFQPQVALGSLPPNPMPQSQQGTMFQSQHSIVAMQSNSPSQEQQQQQQQQQQQQQQQQQSILFSNQNTMATMASPKQPPPNMIFNPNQNPMANQEQQNQSIFHQQSNMAPMNQEQQPMQFQSQSTVSSLQNPGPTQSESSQTPLFHSSPQIQLVQGSPSSQEQQVTLFLSPASMSALQTSINQQDMQQSPLYSPQNNMPGIQGATSSPQPQATLFHNTAGGTMNQLQNSPGSSQQTSGMFLFGIQNNCSQLLTSGPATLPDQLMAISQPGQPQNEGQPPVTTLLSQQMPENSPLASSINTNQNIEKIDLLVSLQNQGNNLTGSF"},{"id":"SEQ_05612","a":"Q96B97","g":"SH3KBP1","d":"SH3 domain-containing kinase-binding protein 1","L":665,"m":[{"c":"VxFxYx[AP]Q[HN]DDEL[TE][IL][SK][VE]G-I[IV][TE]x[IV]x(x){4,6}GWWEGx[IL]NG+[RT]GψFP[DS]NF[VI]+[EL][IL]","u":"51-53","sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed ~51-53 aa globular domain repeats anchored by strictly invariant V, F, Y, Q, DDEL, G, I, GWWEG, N, G, G, FP, and NF motifs separated by a minor 4-6 aa internal loop, while the C-terminal region (607-665) forms an amphipathic coiled-coil heptad.","i":[[6,56,"VEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREI"],[105,155,"VAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKEL"],[274,326,"VIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLL"]]}],"s":"MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK"},{"id":"SEQ_05613","a":"P35527","g":"KRT9","d":"Keratin, type I cytoskeletal 9","L":623,"m":[{"c":"G[SH][RS]GGSGG[SN][YH]GGG(x){1,6}SGG[GS]YGGG[SE]","u":"23-28","sp":"tandem","x":"disordered_like","cf":"high","why":"Four C-terminal disordered repeats (three 28-aa units sharing 79-89% sequence identity plus one 23-aa variant missing 5 internal residues) arranged in two head-to-tail pairs separated by a 10-aa spacer, anchored in fixed register by [RS], [YH], and Y positions following a central coiled-coil rod.","i":[[488,510,"GSRGGSGGSYGGGGSGGGYGGGS"],[511,538,"GSRGGSGGSYGGGSGSGGGSGGGYGGGS"],[549,576,"GHSGGSGGNYGGGSGSGGGSGGGYGGGS"],[577,604,"GSRGGSGGSHGGGSGFGGESGGSYGGGE"]]}],"s":"MSCRQFSSSYLSRSGGGGGGGLGSGGSIRSSYSRFSSSGGGGGGGRFSSSSGYGGGSSRVCGRGGGGSFGYSYGGGSGGGFSASSLGGGFGGGSRGFGGASGGGYSSSGGFGGGFGGGSGGGFGGGYGSGFGGFGGFGGGAGGGDGGILTANEKSTMQELNSRLASYLDKVQALEEANNDLENKIQDWYDKKGPAAIQKNYSPYYNTIDDLKDQIVDLTVGNNKTLLDIDNTRMTLDDFRIKFEMEQNLRQGVDADINGLRQVLDNLTMEKSDLEMQYETLQEELMALKKNHKEEMSQLTGQNSGDVNVEINVAPGKDLTKTLNDMRQEYEQLIAKNRKDIENQYETQITQIEHEVSSSGQEVQSSAKEVTQLRHGVQELEIELQSQLSKKAALEKSLEDTKNRYCGQLQMIQEQISNLEAQITDVRQEIECQNQEYSLLLSIKMRLEKEIETYHNLLEGGQEDFESSGAGKIGLGGRGGSGGSYGRGSRGGSGGSYGGGGSGGGYGGGSGSRGGSGGSYGGGSGSGGGSGGGYGGGSGGGHSGGSGGGHSGGSGGNYGGGSGSGGGSGGGYGGGSGSRGGSGGSHGGGSGFGGESGGSYGGGEEASGSGGGYGGGSGKSSHS"},{"id":"SEQ_05621","a":"P52926","g":"HMGA2","d":"High mobility group protein HMGI-C","L":109,"m":[{"c":"KR[GP]RGRP+","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 8-residue basic-proline-glycine motifs in a disordered sequence, anchored by six invariant positions (K1, R2, R4, G5, R6, P7), a constrained [GP] choice at position 3, and a conserved basic residue (+) at position 8 (followed by an extra K in copies 1 and 3).","i":[[26,33,"KRGRGRPR"],[46,53,"KRPRGRPK"],[74,81,"KRPRGRPR"]]}],"s":"MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQKKPAQEETEETSSQESAEED"},{"id":"SEQ_05624","a":"Q14526","g":"HIC1","d":"Hypermethylated in cancer 1 protein","L":733,"m":[{"c":"[YF]xCxxC[GD]xx[YF]xxxxx[LM]xxHxxxH","u":23,"sp":"dispersed","x":"structured_like","cf":"high","why":"Five 23-residue C2H2-type repeats anchored by invariant CxxC and HxxxH coordination motifs, two conserved aromatics ([YF]), and a large aliphatic ([LM]) core position; the first copy is separated by a 46-aa linker from a cluster of four copies connected by regular 5-aa linkers.","i":[[437,459,"YVCIPCGKGFPSSEQLNAHVEAH"],[507,529,"YRCASCDKSYKDPATLRQHEKTH"],[535,557,"YPCTICGKKFTQRGTMTRHMRSH"],[563,585,"FACDACGMRFTRQYRLTEHMRIH"],[591,613,"YECQVCGGKFAQQRNLISHMKMH"]]}],"s":"MTFPEADILLKSGECAGQTMLDTMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLADGAEAAAAAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYCHLRGGGGGGGGYAPYGRPGRGLRAATPVIQACYPSPVGPPPPPAAEPPSGPEAAVNTHCAELYASGPGPAAALCASERRCSPLCGLDLSKKSPPGSAAPERPLAERELPPRPDSPPSAGPAAYKEPPLALPSLPPLPFQKLEEAAPPSDPFRGGSGSPGPEPPGRPDGPSLLYRWMKHEPGLGSYGDELGRERGSPSERCEERGGDAAVSPGGPPLGLAPPPRYPGSLDGPGAGGDGDDYKSSSEETGSSEDPSPPGGHLEGYPCPHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHVEEEEALYGRAEAAEVAAGAAGLGPPFGGGGDKVAGAPGGLGELLRPYRCASCDKSYKDPATLRQHEKTHWLTRPYPCTICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISHMKMHAVGGAAGAAGALAGLGGLPGVPGPDGKGKLDFPEGVFAVARLTAEQLSLKQQDKAAAAELLAQTTHFLHDPKVALESLYPLAKFTAELGLSPDKAAEVLSQGAHLAAGPDGRTIDRFSPT"},{"id":"SEQ_05632","a":"Q9BZR6","g":"RTN4R","d":"Reticulon-4 receptor","L":473,"m":[{"c":"x[LI]xLxx[NC]x(x){3,4}ψxxxx[FL]xx[LC]xxLx","u":"24-25","sp":"tandem","x":"structured_like","cf":"high","why":"Eight contiguous head-to-tail 24-25 aa leucine-rich repeats defined by a conserved x[LI]xLxx[NC] beta-strand motif and a hydrophobic return segment featuring an aliphatic position (ψ) and a conserved [FL]xx[LC]xxL spine.","i":[[61,84,"RIFLHGNRISHVPAASFRACRNLT"],[85,108,"ILWLHSNVLARIDAAAFTGLALLE"],[109,133,"QLDLSDNAQLRSVDPATFHGLGRLH"],[134,157,"TLHLDRCGLQELGPGLFRGLAALQ"],[158,181,"YLYLQDNALQALPDDTFRDLGNLT"],[182,205,"HLFLHGNRISSVPERAFRGLHSLD"],[206,229,"RLLLHQNRVAHVHPHAFRDLGRLM"],[230,253,"TLYLFANNLSALPTEALAPLRALQ"]]}],"s":"MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC"},{"id":"SEQ_05646","a":"Q03112","g":"MECOM","d":"Histone-lysine N-methyltransferase MECOM","L":1230,"m":[{"c":"xxCxxCx[KRQ]x[FY]xxxxxLxxH(x){3,4}[HC]","u":"23-24","sp":"dispersed","x":"structured_like","cf":"high","why":"Ten 23-24 aa C2H2/C2HC-type repeats with invariant CxxC, aromatic [FY], hydrophobic L, and H(x){3,4}[HC] chelating/core anchors, arranged as an N-terminal outlier plus two periodic arrays (copies 2-7 and 8-10 with 5-6 aa linkers) separated by a long central disordered region.","i":[[209,232,"YRCEDCDQLFESKAELADHQKFPC"],[263,285,"QECKECDQVFPDLQSLEKHMLSH"],[291,313,"YKCDQCPKAFNWKSNLIRHQMSH"],[319,342,"YECENCAKVFTDPSNLQRHIRSQH"],[348,370,"HACPECGKTFATSSGLKQHKHIH"],[376,398,"FICEVCHKSYTQFSNLCRHKRMH"],[405,427,"IKCKDCGQMFSTTSSLNKHRRFC"],[912,934,"YTCRYCGKIFPRSANLTRHLRTH"],[940,963,"YRCKYCDRSFSISSNLQRHVRNIH"],[969,991,"FKCHLCDRCFGQQTNLDRHLKKH"]]}],"s":"MRSKGRARKLATNNECVYGNYPEIPLEEMPDADGVASTPSLNIQEPCSPATSSEAFTPKEGSPYKAPIYIPDDIPIPAEFELRESNMPGAGLGIWTKRKIEVGEKFGPYVGEQRSNLKDPSYGWEILDEFYNVKFCIDASQPDVGSWLKYIRFAGCYDQHNLVACQINDQIFYRVVADIAPGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQQKLESENDLQEIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAAGGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQTNKSQSPLMTHPQILPATQDILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIESDKEKFKENGKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFPDRDLRSLPLKMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTKLTEPRKNHVFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQMSAIENMAEKLESFSALKPEASELLQSVPSMFNFRAPPNALPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERMNGSHFKDEKALVTSQNSDLLDDEEVEDEVLLDEEDEDNDITGKTGKEPVTSNLHEGNPEDDYEETSALEMSCKTSPVRYKEEEYKSGLSALDHIRHFTDSLKMRKMEDNQYSEAELSSFSTSHVPEELKQPLHRKSKSQAYAMMLSLSDKESLHSTSHSSSNVWHSMARAAAESSAIQSISHV"},{"id":"SEQ_05653","a":"Q9BZL4","g":"PPP1R12C","d":"Protein phosphatase 1 regulatory subunit 12C","L":782,"m":[{"c":"xxxGφ[ST][AP]LHxA[AC]xx[EG]xx-φxRφLφxxGxxxxxx","u":33,"sp":"dispersed","x":"structured_like","cf":"high","why":"Four 33-aa structured repeats arranged as two head-to-tail pairs (residues 98-163 and 224-289, each followed by a degenerate C-capping unit) with invariant G4, L8, H9, A11, R21, L23, and G27 anchors plus conserved hydrophobic and acidic positions.","i":[[98,130,"NADGISALHQACIDENLEVVRFLVEQGATVNQA"],[131,163,"DNEGWTPLHVAASCGYLDIARYLLSHGANIAAV"],[224,256,"PRTGASALHVAAAKGYIEVMRLLLQAGYDPELR"],[257,289,"DGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSL"]]}],"s":"MSGEDGPAAGPGAAAAAARERRREQLRQWGARAGAEPGPGERRARTVRFERAAEFLAACAGGDLDEARLMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEEVLSLLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSSPPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVTKPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQRAEAPDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQRDLNPEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERFERRALERKAAELEEELKALSDLRADNQRLKDENAALIRVISKLSK"},{"id":"SEQ_05670","a":"Q8N283","g":"ANKRD35","d":"Ankyrin repeat domain-containing protein 35","L":1001,"m":[{"c":"[DN]xx[GND]x[STD][PA][LF][HMI]φAxxxxxxxxxxxLxxxx[AS]xxxxx","u":33,"sp":"tandem","x":"structured_like","cf":"high","why":"Six head-to-tail tandem 33-residue structured repeats in the N-terminal region (residues 51-248) defined by a conserved [DN]xx[GND]x[STD][PA][LF][HMI]φA core motif, invariant A11 and L23 anchors, and conserved [AS]28.","i":[[51,83,"DSNGQSPFHLAASKGLTECLTILLANGADINSK"],[84,116,"NEDGSTALHLATISCQPQCVKVLLQHGANEDAV"],[117,149,"DAENRSPLHWAASSGCASSVLLLCDHEAFLDVL"],[150,182,"DNDGRTPLMIASLGGHAAICSQLLQRGARVNVT"],[183,215,"DKNDKSALILACEKGSAEVAELLLSHGADAGAV"],[216,248,"DSTGHDALHYALHTQDKALWRHLQQALSRRRRG"]]}],"s":"MKRIFSCSSTQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSRRRRGGQRLVQHPDLASQASPSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRWKYEEERRKVVRLEQELVQKTEECKTQAAAYLDLENQIREQAQELGVLLSWEPRASGKQGSSLRPGGDGMEQGCPKDLLAESTQELKKQQQAAATVNPVLAPKKAEDSAPGKIQYEVHGRSQPEEQGPPQSPASETIRKATGQQLTTNGAQTFGPDHADQLPAGQKESSQVLGVEPGGTVAEPVGPAAMNQLLLQLREELAAVWREKDAARGALSRPVMEGALGTPRAEAAAAAWEKMEARLERVLARLEWAKAGLQVKPEVPSQESREGALKAAPGSIKQDEEKEKRVPGAQGEPLGALGGEKALGGLAKGQLEKEMSVLRLSNSNLLEELGELGRERQRLQRELQSLSQRLQREFVPKPQAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGERSAQSKAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSLKAPASPQVAALEQDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRAREAASLRQHEKTRGSLVAQAQAWGQELKALLEKYNTACREVGRLREAVAEERRRSGDLAAQAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEEVLAIRGENARLALQLQDSQKNHEEIISTYRNHLLNAARGYMEHEVYNILLQILSMEEE"},{"id":"SEQ_05684","a":"Q9BXX3","g":"ANKRD30A","d":"Ankyrin repeat domain-containing protein 30A","L":1397,"m":[{"c":"P[PS]ESKQKDYEE[NS]SWD[ST]ESLCETVSQKDVCLPKA[AT]HQKEIDKINGKLE[EG]SP[NVD][KN]DG[LF]LKA[TNP]C[GR]MKVSIPTKALEL[KM]DMQTFKAEPP[GE]KPSAFEPA[TI]EMQKSVPNKALELKNEQTLRAD[EQ][IM][LF]","u":119,"sp":"tandem","x":"mixed","cf":"high","why":"Three head-to-tail tandem 119-aa repeats (~87% pairwise identity, 104 invariant columns) flanked by partial N- and C-terminal copies in the central region.","i":[[553,671,"PPESKQKDYEENSWDSESLCETVSQKDVCLPKATHQKEIDKINGKLEESPNKDGLLKATCGMKVSIPTKALELKDMQTFKAEPPGKPSAFEPATEMQKSVPNKALELKNEQTLRADEIL"],[672,790,"PSESKQKDYEENSWDTESLCETVSQKDVCLPKAAHQKEIDKINGKLEGSPVKDGLLKANCGMKVSIPTKALELMDMQTFKAEPPEKPSAFEPAIEMQKSVPNKALELKNEQTLRADEIL"],[791,909,"PSESKQKDYEESSWDSESLCETVSQKDVCLPKATHQKEIDKINGKLEESPDNDGFLKAPCRMKVSIPTKALELMDMQTFKAEPPEKPSAFEPAIEMQKSVPNKALELKNEQTLRADQMF"]]},{"c":"[DN]xxxxT[AP][LE][HML]x[AS]xxxxxxxxxxxψψxxxxxφxxx","u":33,"sp":"tandem","x":"structured_like","cf":"high","why":"Six contiguous 33-aa structured tandem repeats anchored by a conserved [DN]xxxxT[AP]L motif and aliphatic core doublets (ψψ and φ).","i":[[70,102,"DAQKRTALHWACVNGHEEVVTFLVDRKCQLDVL"],[103,135,"DGEHRTPLMKALQCHQEACANILIDSGADINLV"],[136,168,"DVYGNTALHYAVYSEILSVVAKLLSHGAVIEVH"],[169,201,"NKASLTPLLLSITKRSEQIVEFLLIKNANANAV"],[202,234,"NKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAA"],[235,267,"DICGVTAEHYAVTCGFHHIHEQIMEYIRKLSKN"]]},{"c":"[GKR]TPD[ET]A[AE][PS]L[AV]E","u":11,"sp":"tandem","x":"disordered_like","cf":"high","why":"Five contiguous 11-aa disordered repeats with six strictly invariant positions (T, P, D, A, L, E) and alternating 2-3 residue choices at every remaining column.","i":[[279,289,"GTPDEAAPLAE"],[290,300,"RTPDTAESLVE"],[301,311,"KTPDEAAPLVE"],[312,322,"RTPDTAESLVE"],[323,333,"KTPDEAASLVE"]]},{"c":"-TPREIxSPAKETSEKFTW[PA]AKGRPRKIAWEKKE","u":34,"sp":"tandem","x":"disordered_like","cf":"high","why":"Two head-to-tail 34-aa disordered repeats sharing 31 of 34 identical residues including twin tryptophan anchors (FTW and IAWE).","i":[[356,389,"ETPREITSPAKETSEKFTWPAKGRPRKIAWEKKE"],[390,423,"DTPREIMSPAKETSEKFTWAAKGRPRKIAWEKKE"]]}],"s":"MEEISAAAVKVVPGPERPSPFSQLVYTSNDSYIVHSGDLRKIHKAASRGQVRKLEKMTKRKKTINLNIQDAQKRTALHWACVNGHEEVVTFLVDRKCQLDVLDGEHRTPLMKALQCHQEACANILIDSGADINLVDVYGNTALHYAVYSEILSVVAKLLSHGAVIEVHNKASLTPLLLSITKRSEQIVEFLLIKNANANAVNKYKCTALMLAVCHGSSEIVGMLLQQNVDVFAADICGVTAEHYAVTCGFHHIHEQIMEYIRKLSKNHQNTNPEGTSAGTPDEAAPLAERTPDTAESLVEKTPDEAAPLVERTPDTAESLVEKTPDEAASLVEGTSDKIQCLEKATSGKFEQSAEETPREITSPAKETSEKFTWPAKGRPRKIAWEKKEDTPREIMSPAKETSEKFTWAAKGRPRKIAWEKKETPVKTGCVARVTSNKTKVLEKGRSKMIACPTKESSTKASANDQRFPSESKQEEDEEYSCDSRSLFESSAKIQVCIPESIYQKVMEINREVEEPPKKPSAFKPAIEMQNSVPNKAFELKNEQTLRADPMFPPESKQKDYEENSWDSESLCETVSQKDVCLPKATHQKEIDKINGKLEESPNKDGLLKATCGMKVSIPTKALELKDMQTFKAEPPGKPSAFEPATEMQKSVPNKALELKNEQTLRADEILPSESKQKDYEENSWDTESLCETVSQKDVCLPKAAHQKEIDKINGKLEGSPVKDGLLKANCGMKVSIPTKALELMDMQTFKAEPPEKPSAFEPAIEMQKSVPNKALELKNEQTLRADEILPSESKQKDYEESSWDSESLCETVSQKDVCLPKATHQKEIDKINGKLEESPDNDGFLKAPCRMKVSIPTKALELMDMQTFKAEPPEKPSAFEPAIEMQKSVPNKALELKNEQTLRADQMFPSESKQKKVEENSWDSESLRETVSQKDVCVPKATHQKEMDKISGKLEDSTSLSKILDTVHSCERARELQKDHCEQRTGKMEQMKKKFCVLKKKLSEAKEIKSQLENQKVKWEQELCSVRLTLNQEEEKRRNADILNEKIREELGRIEEQHRKELEVKQQLEQALRIQDIELKSVESNLNQVSHTHENENYLLHENCMLKKEIAMLKLEIATLKHQYQEKENKYFEDIKILKEKNAELQMTLKLKEESLTKRASQYSGQLKVLIAENTMLTSKLKEKQDKEILEAEIESHHPRLASAVQDHDQIVTSRKSQEPAFHIAGDACLQRKMNVDVSSTIYNNEVLHQPLSEAQRKSKSLKINLNYAGDALRENTLVSEHAQRDQRETQCQMKEAEHMYQNEQDNVNKHTEQQESLDQKLFQLQSKNMWLQQQLVHAHKKADNKSKITIDIHFLERKMQHHLLKEKNEEIFNYNNHLKNRIYQYEKEKAETENS"},{"id":"SEQ_05690","a":"Q14118","g":"DAG1","d":"Dystroglycan 1","L":895,"m":[{"c":"[PT]P[FY]x[PAS]P","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four 6-aa proline-aromatic repeats in the C-terminal disordered tail anchored by invariant P2, aromatic [FY]3, and P6, organized as two duplicated tandem pairs (NAPPYQPPPPFTAP and NMTPYRSPPPYVPP).","i":[[861,866,"PPYQPP"],[867,872,"PPFTAP"],[884,889,"TPYRSP"],[890,895,"PPYVPP"]]}],"s":"MRMSVGLSLLLPLSGRTFLLLLSVVMAQSHWPSEPSEAVRDWENQLEASMHSVLSDLHEAVPTVVGIPDGTAVVGRSFRVTIPTDLIASSGDIIKVSAAGKEALPSWLHWDSQSHTLEGLPLDTDKGVHYISVSATRLGANGSHIPQTSSVFSIEVYPEDHSELQSVRTASPDPGEVVSSACAADEPVTVLTVILDADLTKMTPKQRIDLLHRMRSFSEVELHNMKLVPVVNNRLFDMSAFMAGPGNAKKVVENGALLSWKLGCSLNQNSVPDIHGVEAPAREGAMSAQLGYPVVGWHIANKKPPLPKRVRRQIHATPTPVTAIGPPTTAIQEPPSRIVPTPTSPAIAPPTETMAPPVRDPVPGKPTVTIRTRGAIIQTPTLGPIQPTRVSEAGTTVPGQIRPTMTIPGYVEPTAVATPPTTTTKKPRVSTPKPATPSTDSTTTTTRRPTKKPRTPRPVPRVTTKVSITRLETASPPTRIRTTTSGVPRGGEPNQRPELKNHIDRVDAWVGTYFEVKIPSDTFYDHEDTTTDKLKLTLKLREQQLVGEKSWVQFNSNSQLMYGLPDSSHVGKHEYFMHATDKGGLSAVDAFEIHVHRRPQGDRAPARFKAKFVGDPALVLNDIHKKIALVKKLAFAFGDRNCSTITLQNITRGSIVVEWTNNTLPLEPCPKEQIAGLSRRIAEDDGKPRPAFSNALEPDFKATSITVTGSGSCRHLQFIPVVPPRRVPSEAPPTEVPDRDPEKSSEDDVYLHTVIPAVVVAAILLIAGIIAMICYRKKRKGKLTLEDQATFIKKGVPIIFADELDDSKPPPSSSMPLILQEEKAPLPPPEYPNQSVPETTPLNQDTMGEYTPLRDEDPNAPPYQPPPPFTAPMEGKGSRPKNMTPYRSPPPYVPP"},{"id":"SEQ_05692","a":"Q9HAU5","g":"UPF2","d":"Regulator of nonsense transcripts 2","L":1272,"m":[{"c":"φ+Fψ[AG]EL[TY]xφxψφ[TE]xxxxφxxψ[YK]xx[LT][SK]xxx[NH](x){4,18}ψ[AV][CI][ST]φ[CL]x[TH]CGxxφ","u":"48-62","sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed homologous structured repeats each comprising an ungapped 31-aa N-terminal segment anchored by φ+Fψ[AG]EL and conserved periodic hydrophobics, a variable 4-18 aa linker, and a 13-aa C-terminal segment anchored by an invariant CG dyad (ψ[AV][CI][ST]φ[CL]x[TH]CGxxφ).","i":[[266,319,"LRFIAELTIVGIFTDKEGLSLIYEQLKNIINADRESHTHVSVVISFCRHCGDDI"],[667,714,"VRFIGELTKFKMFTKNDTLHCLKMLLSDFSHHHIEMACTLLETCGRFL"],[872,933,"AKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGSPSSLDPPEHLFRIRLVCTILDTCGQYF"]]}],"s":"MPAERKKPASMEEKDSLPNNKEKDCSERRTVSSKERPKDDIKLTAKKEVSKAPEDKKKRLEDDKRKKEDKERKKKDEEKVKAEEESKKKEEEEKKKHQEEERKKQEEQAKRQQEEEAAAQMKEKEESIQLHQEAWERHHLRKELRSKNQNAPDSRPEENFFSRLDSSLKKNTAFVKKLKTITEQQRDSLSHDFNGLNLSKYIAEAVASIVEAKLKISDVNCAVHLCSLFHQRYADFAPSLLQVWKKHFEARKEEKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKNIINADRESHTHVSVVISFCRHCGDDIAGLVPRKVKSAAEKFNLSFPPSEIISPEKQQPFQNLLKEYFTSLTKHLKRDHRELQNTERQNRRILHSKGELSEDRHKQYEEFAMSYQKLLANSQSLADLLDENMPDLPQDKPTPEEHGPGIDIFTPGKPGEYDLEGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSCQNKESNKDDTKEAKESKENKEVSSPDDLELELENLEINDDTLELEGGDEAEDLTKKLLDEQEQEDEEASTGSHLKLIVDAFLQQLPNCVNRDLIDKAAMDFCMNMNTKANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFRFHVRKKDQINIETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDFSHHHIEMACTLLETCGRFLFRSPESHLRTSVLLEQMMRKKQAMHLDARYVTMVENAYYYCNPPPAEKTVKKKRPPLQEYVRKLLYKDLSKVTTEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLEDIRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGSPSSLDPPEHLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVWTKDHPFPIDIDYMISDTLELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKDSKDSMTEGENLEEDEEEEEGGAETEEQSGNESEVNEPEEEEGSDNDDDEGEEEEEENTDYLTDSNKENETDEENTEVMIKGGGLKHVPCVEDEDFIQALDKMMLENLQQRSGESVKVHQLDVAIPLHLKSQLRKGPPLGGGEGEAESADTMPFVMLTRKGNKQQFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNADLIFKTGGRRR"},{"id":"SEQ_05701","a":"Q9Y283","g":"INVS","d":"Inversin","L":1065,"m":[{"c":"GxT[PA]LHφAAxxGxxxxψxφLψ(x){8,14}xDxx","u":"33-39","sp":"tandem","x":"structured_like","cf":"high","why":"Head-to-tail tandem array of 15 structured 33-39 aa repeats spanning residues 48-556, anchored by a strongly conserved N-terminal GxT[PA]LHφAA motif, an internal ψxφLψ hydrophobic core, and a C-terminal xDxx turn.","i":[[48,80,"GRTPLMYCVLADRLDCADALLKAGADVNKTDHS"],[81,113,"QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLE"],[114,148,"EMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKN"],[149,181,"KQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVE"],[182,220,"GKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYE"],[221,254,"GRTPLHFAVADGNVTVVDVLTSYESCNITSYDNL"],[255,288,"FRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ"],[289,321,"GATPLHYAAQSNFAETVKVFLKHPSVKDDSDLE"],[322,356,"GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKY"],[357,389,"GGTALHAAALSGHVSTVKLLLENNAQVDATDVM"],[390,422,"KHTPLFRACEMGHKDVIQTLIKGGARVDLVDQD"],[423,455,"GHSLLHWAALGGNADVCQILIENKINPNVQDYA"],[456,488,"GRTPLQCAAYGGYINCMAVLMENNADPNIQDKE"],[489,523,"GRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEE"],[524,556,"RYTPLDYALLGERHEVIQFMLEHGALSIAAIQD"]]},{"c":"IQ[AR]xx+x[YK]xψ[RF]+","u":12,"sp":"dispersed","x":"mixed","cf":"medium","why":"Three dispersed 12-aa amphipathic basic motifs in the C-terminal half (downstream of the tandem repeat array) sharing an invariant N-terminal IQ dipeptide, basic residues at positions 6 and 12, and a conserved aliphatic/basic C-terminal ψ[RF]+ triad.","i":[[562,573,"IQAVYKGYKVRK"],[903,914,"IQRERRRKELFR"],[923,934,"IQRAWRSYQLRK"]]}],"s":"MNKSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEENKRKEAEQQKGRRSPDSCRPQALPCLPSTQDVPSRQSRAPSKQPPAGNVAQGPEPRDSRGSPGGSLGGALQKEQHVSSDLQGTNSRRPNETAREHSKGQSACVHFRPNEGSDGSRHPGVPSVEKSRGETAGDERCAKGKGFVKQPSCIRVAGPDEKGEDSRRAAASLPPHDSHWKPSRRHDTEPKAKCAPQKRRTQELRGGRCSPAGSSRPGSARGEAVHAGQNPPHHRTPRNKVTQAKLTGGLYSHLPQSTEELRSGARRLETSTLSEDFQVSKETDPAPGPLSGQSVNIDLLPVELRLQIIQRERRRKELFRKKNKAAAVIQRAWRSYQLRKHLSHLRHMKQLGAGDVDRWRQESTALLLQVWRKELELKFPQTTAVSKAPKSPSKGTSGTKSTKHSVLKQIYGCSHEGKIHHPTRSVKASSVLRLNSVSNLQCIHLLENSGRSKNFSYNLQSATQPKNKTKP"},{"id":"SEQ_05706","a":"Q96RT1","g":"ERBIN","d":"Erbin","L":1412,"m":[{"c":"ψxxφxφxxNxφxxφPxxφxxφ(x){2,3}","u":"23-24","sp":"tandem","x":"structured_like","cf":"high","why":"Contiguous head-to-tail array of 16 structured 23-24 aa repeats (residues 24-392) anchored by conserved N9 and P15 residues and a strict periodic hydrophobic core at positions 1, 4, 6, 11, 14, 18, and 21.","i":[[24,47,"VTTLDYSHCSLEQVPKEIFTFEKT"],[48,70,"LEELYLDANQIEELPKQLFNCQS"],[71,93,"LHKLSLPDNDLTTLPASIANLIN"],[94,116,"LRELDVSKNGIQEFPENIKNCKV"],[117,139,"LTIVEASVNPISKLPDGFSQLLN"],[140,162,"LTQLYLNDAFLEFLPANFGRLTK"],[163,185,"LQILELRENQLKMLPKTMNRLTQ"],[186,208,"LERLDLGSNEFTEVPEVLEQLSG"],[209,231,"LKEFWMDANRLTFIPGFIGSLKQ"],[232,254,"LTYLDVSKNNIEMVEEGISTCEN"],[255,277,"LQDLLLSSNSLQQLPETIGSLKN"],[278,300,"ITTLKIDENQLMYLPDSIGGLIS"],[301,323,"VEELDCSFNEVEALPSSIGQLTN"],[324,346,"LRTFAADHNYLQQLPPEIGSWKN"],[347,369,"ITVLFLHSNKLETLPEEMGDMQK"],[370,392,"LKVINLSDNRLKNLPFSFTKLQQ"]]}],"s":"MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKFKAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEIMERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHDSDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVKITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRGPTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQSYAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSVSSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNASRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKKHPQTSSSGDPCQDGIFISGQQNYSSATLSHKDVPPDSLMKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS"},{"id":"SEQ_05711","a":"Q9C0F0","g":"ASXL3","d":"Putative Polycomb group protein ASXL3","L":2248,"m":[{"c":"xx[PSL][LE]xSE[TAI][ST]xψS","u":12,"sp":"tandem","x":"disordered_like","cf":"high","why":"Seven head-to-tail 12-aa tandem repeats in a central S/T/P/E-rich disordered region (residues 673-756), anchored by invariant SE (positions 6-7), a conserved [ST]xψS C-terminal motif (100% large aliphatic I/V/M at position 11), and an LPLT-like N-terminal half (6/7 L at position 4, 5/7 P at positions 3 and 10).","i":[[673,684,"HASLMSEISPIS"],[685,696,"TSPEISEASLMS"],[697,708,"NLPLTSEASPVS"],[709,720,"NLPLTSETSPMS"],[721,732,"DLPLTSETSSVS"],[733,744,"SMLLTSETTFVS"],[745,756,"SLPLPSETSPIS"]]}],"s":"MKDKRKKKDRTWAEAARLALEKHPNSPMTAKQILEVIQKEGLKETSGTSPLACLNAMLHTNTRIGDGTFFKIPGKSGLYALKKEESSCPADGTLDLVCESELDGTDMAEANAHGEENGVCSKQVTDEASSTRDSSLTNTAVQSKLVSSFQQHTKKALKQALRQQQKRRNGVSMMVNKTVPRVVLTPLKVSDEQSDSPSGSESKNGEADSSDKEMKHGQKSPTGKQTSQHLKRLKKSGLGHLKWTKAEDIDIETPGSILVNTNLRALINKHTFASLPQHFQQYLLLLLPEVDRQMGSDGILRLSTSALNNEFFAYAAQGWKQRLAEGEFTPEMQLRIRQEIEKEKKTEPWKEKFFERFYGEKLGMSREESVKLTTGPNNAGAQSSSSCGTSGLPVSAQTALAEQQPKSMKSPASPEPGFCATLCPMVEIPPKDIMAELESEDILIPEESVIQEEIAEEVETSICECQDENHKTIPEFSEEAESLTNSHEEPQIAPPEDNLESCVMMNDVLETLPHIEVKIEGKSESPQEEMTVVIDQLEVCDSLIPSTSSMTHVSDTEHKESETAVETSTPKIKTGSSSLEGQFPNEGIAIDMELQSDPEEQLSENACISETSFSSESPEGACTSLPSPGGETQSTSEESCTPASLETTFCSEVSSTENTDKYNQRNSTDENFHASLMSEISPISTSPEISEASLMSNLPLTSEASPVSNLPLTSETSPMSDLPLTSETSSVSSMLLTSETTFVSSLPLPSETSPISNSSINERMAHQQRKSPSVSEEPLSPQKDESSATAKPLGENLTSQQKNLSNTPEPIIMSSSSIAPEAFPSEDLHNKTLSQQTCKSHVDTEKPYPASIPELASTEMIKVKNHSVLQRTEKKVLPSPLELSVFSEGTDNKGNELPSAKLQDKQYISSVDKAPFSEGSRNKTHKQGSTQSRLETSHTSKSSEPSKSPDGIRNESRDSEISKRKTAEQHSFGICKEKRARIEDDQSTRNISSSSPPEKEQPPREEPRVPPLKIQLSKIGPPFIIKSQPVSKPESRASTSTSVSGGRNTGARTLADIKARAQQARAQREAAAAAAVAAAASIVSGAMGSPGEGGKTRTLAHIKEQTKAKLFAKHQARAHLFQTSKETRLPPPLSSKEGPPNLEVSSTPETKMEGSTGVIIVNPNCRSPSNKSAHLRETTTVLQQSLNPSKLPETATDLSVHSSDENIPVSHLSEKIVSSTSSENSSVPMLFNKNSVPVSVCSTAISGAIKEHPFVSSVDKSSVLMSVDSANTTISACNISMLKTIQGTDTPCIAIIPKCIESTPISATTEGSSISSSMDDKQLLISSSSASNLVSTQYTSVPTPSIGNNLPNLSTSSVLIPPMGINNRFPSEKIAIPGSEEQATVSMGTTVRAALSCSDSVAVTDSLVAHPTVAMFTGNMLTINSYDSPPKLSAESLDKNSGPRNRADNSGKPQQPPGGFAPAAINRSIPCKVIVDHSTTLTSSLSLTVSVESSEASLDLQGRPVRTEASVQPVACPQVSVISRPEPVANEGIDHSSTFIAASAAKQDSKTLPATCTSLRELPLVPDKLNEPTAPSHNFAEQARGPAPFKSEADTTCSNQYNPSNRICWNDDGMRSTGQPLVTHSGSSKQKEYLEQSCPKAIKTEHANYLNVSELHPRNLVTNVALPVKSELHEADKGFRMDTEDFPGPELPPPAAEGASSVQQTQNMKASTSSPMEEAISLATDALKRVPGAGSSGCRLSSVEANNPLVTQLLQGNLPLEKVLPQPRLGAKLEINRLPLPLQTTSVGKTAPERNVEIPPSSPNPDGKGYLAGTLAPLQMRKRENHPKKRVARTVGEHTQVKCEPGKLLVEPDVKGVPCVISSGISQLGHSQPFKQEWLNKHSMQNRIVHSPEVKQQKRLLPSCSFQQNLFHVDKNGGFHTDAGTSHRQQFYQMPVAARGPIPTAALLQASSKTPVGCNAFAFNRHLEQKGLGEVSLSSAPHQLRLANMLSPNMPMKEGDEVGGTAHTMPNKALVHPPPPPPPPPPPPLALPPPPPPPPPLPPPLPNAEVPSDQKQPPVTMETTKRLSWPQSTGICSNIKSEPLSFEEGLSSSCELGMKQVSYDQNEMKEQLKAFALKSADFSSYLLSEPQKPFTQLAAQKMQVQQQQQLCGNYPTIHFGSTSFKRAASAIEKSIGILGSGSNPATGLSGQNAQMPVQNFADSSNADELELKCSCRLKAMIVCKGCGAFCHDDCIGPSKLCVACLVVR"},{"id":"SEQ_05715","a":"Q9HCU4","g":"CELSR2","d":"Cadherin EGF LAG seven-pass G-type receptor 2","L":2923,"m":[{"c":"xPx[FL]xxxxφ(x){11,15}xx[VI]xxψxAxD(x){8,10}Y(x){23,28}[LV]D[RYN]xxxxxxxφxφx[AV]x[DS](x){12,17}ψxD(x){3,4}[NH]","u":"102-110","sp":"tandem","x":"structured_like","cf":"high","why":"Nine head-to-tail tandem repeats of 102-110 aa defined by conserved N-terminal P-x-[FL], internal [VI]-x-x-ψ-x-A-x-D and Y anchors, central [LV]D[RYN] motif followed by φ-x-φ-x-[AV]-x-[DS], and C-terminal ψ-x-D-(x){3,4}-[NH] motif.","i":[[178,285,"APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDH"],[286,395,"DPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDN"],[396,501,"APQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDN"],[502,606,"APIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDN"],[607,708,"NPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTH"],[709,811,"RPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDN"],[812,917,"APQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDN"],[918,1019,"PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSRATVHVRLLDRNDN"],[1020,1127,"PPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTH"]]},{"c":"CxxxxCxxxxxC(x){6,9}[FY]xCxCxx[GN](x){5,6}C","u":"32-35","sp":"dispersed","x":"structured_like","cf":"high","why":"Five 32-35 aa six-cysteine repeats with invariant C1-x4-C2-x5-C3 N-terminal spacing, a conserved [FY]-x-C4-x-C5 core, and [GN]-(x){5,6}-C6 C-terminal architecture, separated by both short linkers and ~185 aa globular insertions.","i":[[1292,1323,"CYSRPCGPHGRCRSREGGYTCLCRDGYTGEHC"],[1332,1365,"CTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPYC"],[1578,1609,"CDSNTCHNGGTCVNQWDAFSCECPLGFGGKSC"],[1797,1828,"CDSNPCPANSYCSNDWDSYSCSCDPGYYGDNC"],[1832,1866,"CDLNPCEHQSVCTRKPSAPHGYTCECPPNYLGPYC"]]},{"c":"GL(x){7,9}LxLxFxT+xxDGψLL(x){7,9}xxxxLxψxxxxVxLoφ(x){11}φxPGxxoDGxWHxxQL(x){40,68}GGψPx[LP](x){7,10}FxGCψxxψ[QR]V[DS][DS](x){16,20}GC","u":"163-190","sp":"dispersed","x":"structured_like","cf":"high","why":"Two large duplicated globular domains (190 and 163 aa) situated between the cysteine-rich repeats, sharing strongly conserved multi-residue blocks including LxLxFxT+xxDGψLL, PGxxoDGxWHxxQL, GGψPx[LP], and a C-terminal disulfide-paired FxGCψxxψ[QR]V[DS][DS]...(x){16,20}GC motif.","i":[[1382,1571,"GLRQRFHFTLALSFATKERDGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGTQGGSKKSLDLTGPLLLGGVPDLPESFPVRMRQFVGCMRNLQVDSRHIDMADFIANNGTVPGC"],[1629,1791,"GLSLPISQPWYLSLMFRTRQADGVLLQAITRGRSTITLQLREGHVMLSVEGTGLQASSLRLEPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQRAEGNLGPRLHGLHLSNITVGGIPGPAGGVARGFRGCLQGVRVSDTPEGVNSLDPSHGESINVEQGC"]]}],"s":"MRSPATGVPLPTPPPPLLLLLLLLLPPPLLGDQVGPCRSLGSRGRGSSGACAPMGWLCPSSASNLWLYTSRCRDAGTELTGHLVPHHDGLRVWCPESEAHIPLPPAPEGCPWSCRLLGIGGHLSPQGKLTLPEEHPCLKAPRLRCQSCKLAQAPGLRAGERSPEESLGGRRKRNVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSVGQPPGPGGGPPFLPSEDLQERLYLNRSLLTAISAQRVLPFDDNICLREPCENYMRCVSVLRFDSSAPFIASSSVLFRPIHPVGGLRCRCPPGFTGDYCETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPYCQVTTRSFPAHSFITFRGLRQRFHFTLALSFATKERDGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGTQGGSKKSLDLTGPLLLGGVPDLPESFPVRMRQFVGCMRNLQVDSRHIDMADFIANNGTVPGCPAKKNVCDSNTCHNGGTCVNQWDAFSCECPLGFGGKSCAQEMANPQHFLGSSLVAWHGLSLPISQPWYLSLMFRTRQADGVLLQAITRGRSTITLQLREGHVMLSVEGTGLQASSLRLEPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQRAEGNLGPRLHGLHLSNITVGGIPGPAGGVARGFRGCLQGVRVSDTPEGVNSLDPSHGESINVEQGCSLPDPCDSNPCPANSYCSNDWDSYSCSCDPGYYGDNCTNVCDLNPCEHQSVCTRKPSAPHGYTCECPPNYLGPYCETRIDQPCPRGWWGHPTCGPCNCDVSKGFDPDCNKTSGECHCKENHYRPPGSPTCLLCDCYPTGSLSRVCDPEDGQCPCKPGVIGRQCDRCDNPFAEVTTNGCEVNYDSCPRAIEAGIWWPRTRFGLPAAAPCPKGSFGTAVRHCDEHRGWLPPNLFNCTSITFSELKGFAERLQRNESGLDSGRSQQLALLLRNATQHTAGYFGSDVKVAYQLATRLLAHESTQRGFGLSATQDVHFTENLLRVGSALLDTANKRHWELIQQTEGGTAWLLQHYEAYASALAQNMRHTYLSPFTIVTPNIVISVVRLDKGNFAGAKLPRYEALRGEQPPDLETTVILPESVFRETPPVVRPAGPGEAQEPEELARRQRRHPELSQGEAVASVIIYRTLAGLLPHNYDPDKRSLRVPKRPIINTPVVSISVHDDEELLPRALDKPVTVQFRLLETEERTKPICVFWNHSILVSGTGGWSARGCEVVFRNESHVSCQCNHMTSFAVLMDVSRRENGEILPLKTLTYVALGVTLAALLLTFFFLTLLRILRSNQHGIRRNLTAALGLAQLVFLLGINQADLPFACTVIAILLHFLYLCTFSWALLEALHLYRALTEVRDVNTGPMRFYYMLGWGVPAFITGLAVGLDPEGYGNPDFCWLSIYDTLIWSFAGPVAFAVSMSVFLYILAARASCAAQRQGFEKKGPVSGLQPSFAVLLLLSATWLLALLSVNSDTLLFHYLFATCNCIQGPFIFLSYVVLSKEVRKALKLACSRKPSPDPALTTKSTLTSSYNCPSPYADGRLYQPYGDSAGSLHSTSRSGKSQPSYIPFLLREESALNPGQGPPGLGDPGSLFLEGQDQQHDPDTDSDSDLSLEDDQSGSYASTHSSDSEEEEEEEEEEAAFPGEQGWDSLLGPGAERLPLHSTPKDGGPGPGKAPWPGDFGTTAKESSGNGAPEERLRENGDALSREGSLGPLPGSSAQPHKGILKKKCLPTISEKSSLLRLPLEQCTGSSRGSSASEGSRGGPPPRPPPRQSLQEQLNGVMPIAMSIKAGTVDEDSSGSEFLFFNFLH"},{"id":"SEQ_05726","a":"Q9NYL2","g":"MAP3K20","d":"Mitogen-activated protein kinase kinase kinase 20","L":800,"m":[{"c":"[ST][SP]xRGRY[SP][GD]+","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 10-residue copies in the C-terminal Ser/Pro-enriched disordered region share an invariant RGRY tetrapeptide core flanked by conserved N-terminal [ST][SP] and C-terminal [SP][GD]+ positions.","i":[[667,676,"SSERGRYSDR"],[690,699,"SSPRGRYSGK"],[704,713,"TPSRGRYPGK"]]}],"s":"MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPLIKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNTNLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQDEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSPFFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFSSGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQSALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRPSPAKTNKERARGDHRGWRNF"},{"id":"SEQ_05743","a":"O75154","g":"RAB11FIP3","d":"Rab11 family-interacting protein 3","L":756,"m":[{"c":"ψ+xψxxφLD[GP]xGxGφψxφEDFφQxφTφφ","u":28,"sp":"dispersed","x":"structured_like","cf":"high","why":"Strongly conserved 28-residue internal duplication separated by a 4-residue turn, anchored by invariant LD, GxG, EDF, Q, and T positions flanked by conserved hydrophobic and basic residues.","i":[[207,234,"LRAVFDALDGDGDGFVRIEDFIQFATVY"],[239,266,"VKDLTKYLDPSGLGVISFEDFYQGITAI"]]}],"s":"MASAPPASPPGSEPPGPDPEPGGPDGPGAAQLAPGPAELRLGAPVGGPDPQSPGLDEPAPGAAADGGARWSAGPAPGLEGGPRDPGPSAPPPRSGPRGQLASPDAPGPGPRSEAPLPELDPLFSWTEEPEECGPASCPESAPFRLQGSSSSHRARGEVDVFSPFPAPTAGELALEQGPGSPPQPSDLSQTHPLPSEPVGSQEDGPRLRAVFDALDGDGDGFVRIEDFIQFATVYGAEQVKDLTKYLDPSGLGVISFEDFYQGITAIRNGDPDGQCYGGVASAQDEEPLACPDEFDDFVTYEANEVTDSAYMGSESTYSECETFTDEDTSTLVHPELQPEGDADSAGGSAVPSECLDAMEEPDHGALLLLPGRPHPHGQSVITVIGGEEHFEDYGEGSEAELSPETLCNGQLGCSDPAFLTPSPTKRLSSKKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEEINFRLQDYIDRIIVAIMETNPSILEVK"},{"id":"SEQ_05744","a":"Q8TAZ6","g":"CMTM2","d":"CKLF-like MARVEL transmembrane domain-containing protein 2","L":248,"m":[{"c":"D[GH]KEPSDKPQKAVQ","u":14,"sp":"tandem","x":"disordered_like","cf":"high","why":"Head-to-tail tandem 14-residue duplication in the N-terminal polar/proline-rich tail with 13 of 14 positions strictly identical across diverse charged, polar, proline, and aliphatic anchors.","i":[[30,43,"DGKEPSDKPQKAVQ"],[44,57,"DHKEPSDKPQKAVQ"]]}],"s":"MAPKAAKGAKPEPAPAPPPPGAKPEEDKKDGKEPSDKPQKAVQDHKEPSDKPQKAVQPKHEVGTRRGCRRYRWELKDSNKEFWLLGHAEIKIRSLGCLIAAMILLSSLTVHPILRLIITMEISFFSFFILLYSFAIHRYIPFILWPISDLFNDLIACAFLVGAVVFAVRSRRSMNLHYLLAVILIGAAGVFAFIDVCLQRNHFRGKKAKKHMLVPPPGKEKGPQQGKGPEPAKPPEPGKPPGPAKGKK"},{"id":"SEQ_05746","a":"O75864","g":"PPP1R37","d":"Protein phosphatase 1 regulatory subunit 37","L":691,"m":[{"c":"φxxψxφxxoxψxxxxxxφxxφ(x){6,8}","u":"27-29","sp":"tandem","x":"structured_like","cf":"high","why":"Contiguous 12-copy head-to-tail tandem array of 27-29 aa structured units defined by a conserved φxxψxφxxoxψ core (predominantly LxxLxLxxNxL) followed by periodic amphipathic hydrophobic positions.","i":[[109,135,"LDCLDLKGEKLDYKTCEALEEVFKRLQ"],[136,163,"FKVVDLEQTNLDEDGASALFDMIEYYES"],[164,192,"ATHLNISFNKHIGTRGWQAAAHMMRKTSC"],[193,220,"LQYLDARNTPLLDHSAPFVARALRIRSS"],[221,248,"LAVLHLENASLSGRPLMLLATALKMNMN"],[249,277,"LRELYLADNKLNGLQDSAQLGNLLKFNCS"],[278,306,"LQILDLRNNHVLDSGLAYICEGLKEQRKG"],[307,334,"LVTLVLWNNQLTHTGMAFLGMTLPHTQS"],[335,362,"LETLNLGHNPIGNEGVRHLKNGLISNRS"],[363,390,"VLRLGLASTKLTCEGAVAVAEFIAESPR"],[391,418,"LLRLDLRENEIKTGGLMALSLALKVNHS"],[419,446,"LLRLDLDREPKKEAVKSFIETQKALLAE"]]}],"s":"MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDIVSGAVEPKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDEDGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETPCPALVPPTDSLGPGDRSPPGSPSTPTEQRISVSSPGRGHKVFVVTRVESPPERAEPPASPTPPSPPPPPSPPASPSLPPAGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHELSCSKNEKELEELLLEASQESGQETL"},{"id":"SEQ_05756","a":"Q6PRD1","g":"GPR179","d":"Probable G protein-coupled receptor 179","L":2367,"m":[{"c":"x[AE][EAD]ψC[PL]W-","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Twenty dispersed copies of an 8-residue CPWE-centered motif occur across the disordered C-terminal tail (residues 999-2223), anchored by invariant C and W, a conserved C-terminal acidic position (E/D), a preceding aliphatic ψ (V/I/L in 18/20 copies), and an upstream [AE][EAD] preference; most copies are arranged within higher-order ~114-aa triplet repeat cassettes alongside several additional degenerate variants.","i":[[989,996,"LTYICPWE"],[1240,1247,"VAEVCPWE"],[1261,1268,"KAEICPWE"],[1317,1324,"QEAVCPWE"],[1377,1384,"KAEPCPWE"],[1424,1431,"LESLCPWE"],[1459,1466,"IAEVCLWE"],[1475,1482,"KAEICPWE"],[1589,1596,"KTEICPWE"],[1701,1708,"KAEICPWE"],[1798,1805,"PGEVCPWE"],[1814,1821,"KAKICPWE"],[1870,1877,"QETICIWE"],[1954,1961,"LQSVCPWE"],[1994,2001,"AADVCPWD"],[2015,2022,"KAETCPWE"],[2071,2078,"QEAVCPWE"],[2111,2118,"VAEVCLWE"],[2127,2134,"KAEICPWE"],[2218,2225,"MAELCQWE"]]}],"s":"MGTRGAVMPPPMWGLLGCCFVCAWALGGPRPIRSLPPLSSQVKPGSVPMQVPLEGAEAALAYLYSGDAQQLSQVNCSERYEARGAGAMPGLPPSLQGAAGTLAQAANFLNMLLQANDIRESSVEEDVEWYQALVRSVAEGDPRVYRALLTFNPPPGASHLQLALQATRTGEETILQDLSGNWVQEENPPGDLDTPALKKRVLTNDLGSLGSPKWPQADGYVGDTQQVRLSPPFLECQEGRLRPGWLITLSATFYGLKPDLSPEVRGQVQMDVDLQSVDINQCASGPGWYSNTHLCDLNSTQCVPLESQGFVLGRYLCRCRPGFYGASPSGGLEESDFQTTGQFGFPEGRSGRLLQCLPCPEGCTSCMDATPCLVEEAAVLRAAVLACQACCMLAIFLSMLVSYRCRRNKRIWASGVVLLETVLFGFLLLYFPVFILYFKPSVFRCIALRWVRLLGFAIVYGTIILKLYRVLQLFLSRTAQRSALLSSGRLLRRLGLLLLPVLGFLAVWTVGALERGIQHAPLVIRGHTPSGRHFYLCHHDRWDYIMVVAELLLLCWGSFLCYATRAVLSAFHEPRYMGIALHNELLLSAAFHTARFVLVPSLHPDWTLLLFFFHTHSTVTTTLALIFIPKFWKLGAPPREEMVDEVCEDELDLQHSGSYLGSSIASAWSEHSLDPGDIRDELKKLYAQLEVHKTKEMAANNPHLPKKRGSSCQGLGRSFMRYLAEFPEALARQHSRDSGSPGHGSLPGSSRRRLLSSSLQEPEGTPALHKSRSTYDQRREQDPPLLDSLLRRKLAKKASRTESRESVEGPPALGFRSASAHNLTVGERLPRARPASLQKSLSVASSREKALLMASQAYLEETYRQAKEREERKKAKAAMASLVRRPSARRLERPRGAPLSAPPSPAKSSSVDSSHTSGRLHEEARRRLPHPPIRHQVSTPILALSGGLGEPRMLSPTSTLAPALLPALAPTPAPALAPVPVSPQSPNLLTYICPWENAELPAKQENVPQEGPSGPERGHHSPAPARARLWRALSVAVEKSRAGENEMDAEDAHHQREANDVDEDRPKIFPKSHSLKAPVQQGSMRSLGLAIKALTRSRSTYREKESVEESPEGQNSGTAGESMGAPSRSPRLGRPKAVSKQAALIPSDDKESLQNQQNAHTSRMLQVCQREGSREQEDRGRRMTQGLGERKAERAGKTGLAMLRQVSRDKNIKQSKETPVGWQELPKAGLQSLGSADHRVAEVCPWEVTESETRQPDSGNKAEICPWETSEGAPESRALRQDPGDSQKKRGEARGKSEPIDVVPMMRKKPERLVREQEAVCPWESADRGGLSPGSAPQDPGRIRDKSEAGDSVEARKVEKPGWEAAGPEAHTPDITKAEPCPWEASEGGEDGKPAQEAVKDLPQEKQKTRKATFWKEQKPGGDLESLCPWESTDFRGPSAVSIQAPGSSECSGSLGSGIAEVCLWEAGDAPAIQKAEICPWELDDNVMGQEMLSLGTGRESLQEKEKASRKGSFGEMGEQTVKAVQKLSQQQESVCPRESTVPGHSSPCLDNSSSKAGSQFLCNGGSRATQVCPQEDLRPEAQEATPAKTEICPWEVNERTREEWTSAQVPRGGESQKDKEKMPGKSEIEDVTAWEKPEGQIQKQEAVGPWESVDPGSFSPQPRPQDTERPQTLLQMSGSVGSKAADICPLDVEENLTAGKAEICPWEVGAGAGEERALGAEAIRKSPNDTGKVSADLGPRERAVTAPEKPQKPTPEWEVACPWGSVGPGACSQHPGTLDADGPKAGFQELDHMGCRPGEVCPWEAQEAATSEKAKICPWEVSEGTTGKGLDQKAGSESAEQREKALEKGRLTSLGEDVSKGMAKLCQQQETICIWENKDLRESPAQAPKISDLPSSMSSEVAEGHSLEATEKGDLRQDPKTGSFPEHITQEKAPAADTEEFTTEDGEKTSHELQSVCPWETTAPADSVSHLDRQRPDQPKASSQRLVSTGGRAADVCPWDVPDAGVYKSDSSAKAETCPWEVTERIPVKGVSRQDGKGDSQEEKGRAPEKSEPKGVPVQKKPEMADFRQQEAVCPWESQDGKGLSPQPAPDASDRSRGSSEAAGSVETRVAEVCLWEVVEAPSAKKAEICPWEAGGGAAEEGEQERESQGQGEMFLQKAGPGGTEEHFSKAAAKPREQEAVCPGEGTGSGGLLPQSGALDPELKVSPKEAGSMGSRMAELCQWEITDPEGNKIKGTMADICPGEETGVPSEESGLLALTATRREFFPTAPEKPLCLLVHGPLDHFFPESKIPCPKVSRPASTFTLEGVRELQGPSGLEPRTSLAPEPSLQEAESQSSSLTEDSGQVAFEAQYEEFTPPTVYPWDWE"},{"id":"SEQ_05758","a":"Q92837","g":"FRAT1","d":"Proto-oncogene FRAT1","L":279,"m":[{"c":"[DE]DxxxLLQQxVφxG(x){3,4}E[AV]xRx[LV](x){4,6}LQLxA","u":"33-34","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of a 33-34 aa helical/LRR-like segment anchored by conserved N-terminal [DE]DxxxLLQQxVφxG, central E[AV]xRx[LV], and C-terminal LQLxA motifs (further supported by upstream PCRR caps).","i":[[22,55,"EDSFLLLQQSVALGSSGEVDRLVAQIGETLQLDA"],[197,229,"DDPHRLLQQLVLSGNLIKEAVRRLHSRRLQLRA"]]}],"s":"MPCRREEEEEAGEEAEGEEEEEDSFLLLQQSVALGSSGEVDRLVAQIGETLQLDAAQHSPASPCGPPGAPLRAPGPLAAAVPADKARSPAVPLLLPPALAETVGPAPPGVLRCALGDRGRVRGRAAPYCVAELATGPSALSPLPPQADLDGPPGAGKQGIPQPLSGPCRRGWLRGAAASRRLQQRRGSQPETRTGDDDPHRLLQQLVLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGPLSAPVHEPPSPRSPRAACSDPGASGRAQLRTGDGVLVPGS"},{"id":"SEQ_05768","a":"Q96K62","g":"ZBTB45","d":"Zinc finger and BTB domain-containing protein 45","L":511,"m":[{"c":"C[ASP]xCx+xF[ST]x+xx[LY]xxH[ML]xxH","u":21,"sp":"periodic","x":"structured_like","cf":"high","why":"Four periodic 21-aa Cys2-His2 repeats in the C-terminal region separated by 6-7 aa linkers, defined by invariant CxxC and HxxxH coordination pairs, a conserved central F[ST]x+xx[LY] core, and basic (+) positions.","i":[[405,425,"CSHCRKTFSSRKNYTKHMFIH"],[433,453,"CAVCWRSFSLRDYLLKHMVTH"],[461,481,"CAVCAKRFTQKSSLNVHMRTH"],[488,508,"CPACGKVFSHRALLERHLAAH"]]}],"s":"MAAAEAVHHIHLQNFSRSLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQDKLLLGHSEIRVPPVVPAQTVRQLVEFLYSGSLVVAQGEALQVLTAASVLRIQTVIDECTQIIARARAPGTSAPTPLPTPVPPPLAPAQLRHRLRHLLAARPPGHPGAAHSRKQRQPARLQLPAPPTPAKAEGPDADPSLSAAPDDRGDEDDEESDDETDGEDGEGGGPGEGQAPPSFPDCAAGFLTAAADSACEEPPAPTGLADYSGAGRDFLRGAGSAEDVFPDSYVSTWHDEDGAVPEGCPTETPVQPDCILSGSRPPGVKTPGPPVALFPFHLGAPGPPAPPPSAPSGPAPAPPPAFYPTLQPEAAPSTQLGEVPAPSAAPTTAPSGTPARTPGAEPPTYECSHCRKTFSSRKNYTKHMFIHSGEKPHQCAVCWRSFSLRDYLLKHMVTHTGVRAFQCAVCAKRFTQKSSLNVHMRTHRPERAPCPACGKVFSHRALLERHLAAHPAP"},{"id":"SEQ_05771","a":"E9PAV3","g":"NACA","d":"Nascent polypeptide-associated complex subunit alpha, muscle-specific form","L":2078,"m":[{"c":"[PS]xPKGAPT[PT]PA[AV]TPPSPKGG[PL](x){0,1}AT","u":"22-24","sp":"tandem","x":"disordered_like","cf":"high","why":"Extensive 23-residue (22-24 aa) disordered tandem repeat array composed of paired 14-aa (PxPKGAPT[PT]PA[AV]TP) and 9-aa (PSPKGG[PL]AT) proline/lysine-anchored sub-motifs, with 17 uninterrupted head-to-tail copies in residues 934-1326 followed by 6 slightly diverged copies separated by partial-repeat linkers.","i":[[934,956,"PSPKGAPTPPAATPPSPKGGPAT"],[957,979,"PSPKWAPTPPAATPPSPKGGPAT"],[980,1002,"PSPKGAPTPPAATPPSPKGGPAT"],[1003,1026,"PSPKGAPTPPAVTPPSPKGSPAAT"],[1027,1050,"PFPKGASTPPAATPPSPKGSPAAT"],[1051,1073,"PLPKGAPTTPAATLPSPKGGPAT"],[1074,1096,"PSLKGAPTPPAATPPSPKGGPAT"],[1097,1119,"PSPKGAPMPPAATPPSPKGGLAT"],[1120,1142,"PPHKGAPTTPAATPPSPKGGLAT"],[1143,1165,"PPPKGAPTTPAATPPSPKGGLAT"],[1166,1188,"PPPKGAPTTPAATPPSPKGGLAT"],[1189,1211,"PSPKGAPTTPAATPPSPKGGLAT"],[1212,1234,"PSPKGAPTTPAATPPSPKGGLAT"],[1235,1257,"PSPKGAPTTPAATPPSPKGGPAT"],[1258,1280,"PPPKGAPTPPAATPPSLKGGLAT"],[1281,1303,"PPHKGAPNPAVVTPPSPKGGPAT"],[1304,1326,"SPPKGAPTPPAATPPSPKGSPGT"],[1341,1362,"PSPKGTPTLPATTPSSKGGPTT"],[1363,1385,"PSSKEGPTPPAATPSHKGGPAMT"],[1396,1418,"PSPKGDPTSPAVIPLSPKKAPAT"],[1428,1449,"PSKGDLTPPAVTPVSLKKAPAT"],[1497,1519,"PAPMGAPTLPAVIPSSPKEVPAT"],[1608,1630,"PSPKEAPTPPAVTPPSPEKGPAT"]]}],"s":"MPGEATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASPFPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAPIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTSSQKTAGPNTPPDFPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDKGPSTISSITCSPSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPELEEQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEEEVDETGVEVKDIELVMSQANVSRAKAVRALKNNSNDIVNAIMELTM"},{"id":"SEQ_05773","a":"Q96MK2","g":"RIPOR3","d":"RIPOR family member 3","L":946,"m":[{"c":"ExxxxxGR(x){8,9}ψφφφ(x){3,9}ψExHψ(x){1,3}EFHI(x){7,9}YxxxC(x){1,3}xxxxxψxxxφ[AG]R","u":"58-71","sp":"dispersed","x":"structured_like","cf":"high","why":"Two adjacent 58-71 aa structured domain copies separated by an 8-residue linker share a strongly conserved beta-hairpin core (ψExHψ(x){1,3}EFHI) flanked by collinear ExxxxxGR, hydrophobic ψφφφ, YxxxC, and C-terminal ψxxxφ[AG]R amphipathic elements.","i":[[95,165,"ELDHLSGRHKDTRRNSRLAFYYDLDKQTRCVERHIRKMEFHISKVDELYEDYCIQCRLRDGASSMQRAFAR"],[174,231,"ESLQELGRSLHECAEDMWLIEGALEVHLGEFHIRMKGLVGYARLCPGDHYEVLMRLGR"]]}],"s":"MSVRLRFLSPGDTGAVGVVGRSASFAGFSSAQSRRIAKSINRNSVRSRMPAKSSKMYGTLRKGSVCADPKPQQVKKIFEALKRGLKEYLCVQQAELDHLSGRHKDTRRNSRLAFYYDLDKQTRCVERHIRKMEFHISKVDELYEDYCIQCRLRDGASSMQRAFARCPPSRAARESLQELGRSLHECAEDMWLIEGALEVHLGEFHIRMKGLVGYARLCPGDHYEVLMRLGRQRWKLKGRIESDDSQTWDEEEKAFIPTLHENLDIKVTELRGLGSLAVGAVTCDIADFFTTRPQVIVVDITELGTIKLQLEVQWNPFDTESFLVSPSPTGKFSMGSRKGSLYNWTPPSTPSFRERYYLSVLQQPTQQALLLGGPRATSILSYLSDSDLRGPSLRSQSQELPEMDSFSSEDPRDTETSTSASTSDVGFLPLTFGPHASIEEEAREDPLPPGLLPEMAHLSGGPFAEQPGWRNLGGESPSLPQGSLFHSGTASSSQNGHEEGATGDREDGPGVALEGPLQEVLELLRPTDSTQPQLRELEYQVLGFRDRLKPCRARQEHTSAESLMECILESFAFLNADFALDELSLFGGSQGLRKDRPLPPPSSLKASSRELTAGAPELDVLLMVHLQVCKALLQKLASPNLSRLVQECLLEEVAQQKHVLETLSVLDFEKVGKATSIEEIIPQASRTKGCLKLWRGCTGPGRVLSCPATTLLNQLKKTFQHRVRGKYPGQLEIACRRLLEQVVSCGGLLPGAGLPEEQIITWFQFHSYLQRQSVSDLEKHFTQLTKEVTLIEELHCAGQAKVVRKLQGKRLGQLQPLPQTLRAWALLQLDGTPRVCRAASARLAGAVRNRSFREKALLFYTNALAENDARLQQAACLALKHLKGIESIDQTASLCQSDLEAVRAAARETTLSFGEKGRLAFEKMDKLCSEQREVFCQEADVEITIF"},{"id":"SEQ_05781","a":"Q13094","g":"LCP2","d":"Lymphocyte cytosolic protein 2","L":533,"m":[{"c":"--xDYE[SP]P","u":8,"sp":"periodic","x":"disordered_like","cf":"high","why":"Three closely spaced copies (separated by 7-9 aa acidic linkers) in an N-proximal disordered segment share an invariant DYE core preceded by a di-acidic pair and followed by [SP]P.","i":[[109,116,"EEDDYESP"],[124,131,"DDGDYESP"],[141,148,"DDADYEPP"]]},{"c":"[KQ][KQ]PPφ[PS]","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Four non-overlapping copies in the central proline-rich disordered region (including three spaced ~14-15 aa apart) feature a diproline core anchored N-terminally by [KQ][KQ] and C-terminally by a hydrophobic residue plus [PS].","i":[[184,189,"QQPPVP"],[259,264,"KKPPFS"],[283,288,"QKPPLP"],[303,308,"KKPPVP"]]}],"s":"MALRNVPFRSEVLGWDPDSLADYFKKLNYKDCEKAVKKYHIDGARFLNLTENDIQKFPKLRVPILSKLSQEINKNEERRSIFTRKPQVPRFPEETESHEEDNGGWSSFEEDDYESPNDDQDGEDDGDYESPNEEEEAPVEDDADYEPPPSNDEEALQNSILPAKPFPNSNSMYIDRPPSGKTPQQPPVPPQRPMAALPPPPAGRNHSPLPPPQTNHEEPSRSRNHKTAKLPAPSIDRSTKPPLDRSLAPFDREPFTLGKKPPFSDKPSIPAGRSLGEHLPKIQKPPLPPTTERHERSSPLPGKKPPVPKHGWGPDRRENDEDDVHQRPLPQPALLPMSSNTFPSRSTKPSPMNPLPSSHMPGAFSESNSSFPQSASLPPYFSQGPSNRPPIRAEGRNFPLPLPNKPRPPSPAEEENSLNEEWYVSYITRPEAEAALRKINQDGTFLVRDSSKKTTTNPYVLMVLYKDKVYNIQIRYQKESQVYLLGTGLRGKEDFLSVSDIIDYFRKMPLLLIDGKNRGSRYQCTLTHAAGYP"},{"id":"SEQ_05787","a":"Q9Y5H6","g":"PCDHA8","d":"Protocadherin alpha-8","L":950,"m":[{"c":"(x){13,17}xφxxxx[AV]xDx[DG]x[GEQ]x[NA]xxψ[STP][YRC](x){25,30}[LI]Dx[EA](x){16,19}P(x){3,5}xxψxVxψx-x[NG][DQ][NA][AVP][PK](x){0,2}","u":"104-110","sp":"tandem","x":"structured_like","cf":"high","why":"Six tandem ~104-110 aa structured repeats (copies 1-5 strictly head-to-tail and copy 6 separated by an 8-aa linker) anchored by invariant D, [LI]Dx[EA], and P positions, conservedDxDxGxNxxψ[STP]Y motifs, and C-terminal ψxVxψxD[VKE]NDN[AV]P motifs in copies 1-5.","i":[[30,133,"QLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDVNDNPPVF"],[134,242,"RVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYFMLDVNSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTF"],[243,350,"EQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEI"],[351,455,"ALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAF"],[456,565,"AQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL"],[574,677,"GGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPK"]]}],"s":"MDYHWRGELGSWRLLLLLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYFMLDVNSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRQSAGVLGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSALPTEGGCRAGKPTLVCSSAVGSWSYSQQQPQRVCSGEGPPKTDLMAFSPCLPPDLGSVDVGEEQDLNVDHGLKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ"},{"id":"SEQ_05803","a":"Q9UBV2","g":"SEL1L","d":"Protein sel-1 homolog 1","L":794,"m":[{"c":"[AGE]xxxx[GAS]xxxxx(x){0,8}xxxxxxAxxxΩxxxxxxxxxx(x){0,1}","u":"32-40","sp":"tandem","x":"structured_like","cf":"high","why":"Twelve tandem 32-40 aa (predominantly 36 aa) helical-hairpin-like repeats organized in two head-to-tail blocks separated by a 46-aa insertion; most units feature an N-terminal LGxxxxxGxG[VTI] turn, and all twelve share invariant A and aromatic (F/Y/W) anchors followed by small/hydrophobic [LA]AxxG positions in the second half.","i":[[221,256,"ALERVSYALLFGDYLPQNIQAAREMFEKLTEEGSPK"],[257,292,"GQTALGFLYASGLGVNSSQAKALVYYTFGALGGNLI"],[293,328,"AHMVLGYRYWAGIGVLQSCESALTHYRLVANHVASD"],[375,411,"AQVGLGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSH"],[412,448,"AMAFLGKMYSEGSDIVPQSNETALHYFKKAADMGNPV"],[449,484,"GQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVD"],[485,520,"GQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHIL"],[521,556,"AFYNLAQMHASGTGVMRSCHTAVELFKNVCERGRWS"],[557,588,"ERLMTAYNSYKDGDYNAAVIQYLLLAEQGYEV"],[589,628,"AQSNAAFILDQREASIVGENETYPRALLHWNRAASQGYTV"],[629,665,"ARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQHSAQ"],[666,701,"AMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEASPDA"]]}],"s":"MRVRIGLTLLLCAVLLSLASASSDEEGSQDESLDSKTTLTSDESVKDHTTAGRVVAGQIFLDSEESELESSIQEEEDSLKSQEGESVTEDISFLESPNPENKDYEEPKKVRKPALTAIEGTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFCETEEEAAKRRQMQEAEMMYQTGMKILNGSNKKSQKREAYRYLQKAASMNHTKALERVSYALLFGDYLPQNIQAAREMFEKLTEEGSPKGQTALGFLYASGLGVNSSQAKALVYYTFGALGGNLIAHMVLGYRYWAGIGVLQSCESALTHYRLVANHVASDISLTGGSVVQRIRLPDEVENPGMNSGMLEEDLIQYYQFLAEKGDVQAQVGLGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNETALHYFKKAADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAVELFKNVCERGRWSERLMTAYNSYKDGDYNAAVIQYLLLAEQGYEVAQSNAAFILDQREASIVGENETYPRALLHWNRAASQGYTVARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQHSAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEASPDAQVPVFLALCKLGVVYFLQYIRETNIRDMFTQLDMDQLLGPEWDLYLMTIIALLLGTVIAYRQRQHQDMPAPRPPGPRPAPPQQEGPPEQQPPQ"},{"id":"SEQ_05810","a":"Q9HBE1","g":"PATZ1","d":"POZ-, AT hook-, and zinc finger-containing protein 1","L":687,"m":[{"c":"CxxC[GN]xx[FL](x){4,5}[LM]xxH(x){3,4}H","u":"20-22","sp":"dispersed","x":"structured_like","cf":"high","why":"Eight 20-22 aa repeats anchored by invariant N-terminal CxxC and C-terminal H(x){3,4}H motifs alongside conserved [GN], [FL], and [LM] core positions, arranged as a central six-copy cluster (5-9 aa linkers) flanked by two distal copies (42 and 88 aa linkers).","i":[[294,314,"CGLCGKVFTDANRLRQHEAQH"],[357,377,"CEICGKIFRDVYHLNRHKLSH"],[385,405,"CPVCGLRFKRKDRMSYHVRSH"],[415,436,"CQSCGKGFSRPDHLNGHIKQVH"],[444,464,"CQTCNASFATRDRLRSHLACH"],[470,489,"CQVCGKYLRAAYMADHLKKH"],[497,517,"CSICNRGFSSASYLKVHVKTH"],[607,628,"CPECGSFFRSKSYLNKHIQKVH"]]}],"s":"MERVNDASCGPSGCYTYQVSRHSTEMLHNLNQQRKNGGRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAADGGPADVGGATAAPGGGAGGSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQSNVQILVPPARADIMLFRPPGTSDLGFPLDMTNGAALAANSNGIAGSMQPEEEAARAAGAAIAGQASLPVLPGVDRLPMVAGPLSPQLLTSPFPSVASSAPPLTGKRGRGRPRKANLLDSMFGSPGGLREAGILPCGLCGKVFTDANRLRQHEAQHGVTSLQLGYIDLPPPRLGENGLPISEDPDGPRKRSRTRKQVACEICGKIFRDVYHLNRHKLSHSGEKPYSCPVCGLRFKRKDRMSYHVRSHDGSVGKPYICQSCGKGFSRPDHLNGHIKQVHTSERPHKCQTCNASFATRDRLRSHLACHEDKVPCQVCGKYLRAAYMADHLKKHSEGPSNFCSICNRGFSSASYLKVHVKTHHGVPLPQVSRHQEPILNGGAAFHCARTYGNKEGQKCSHQDPIESSDSYGDLSDASDLKTPEKQSANGSFSCDMAVPKNKMESDGEKKYPCPECGSFFRSKSYLNKHIQKVHVRALGGPLGDLGPALGSPFSPQQNMSLLESFGFQIVQSAFASSLVDPEVDQQPMGPEGK"},{"id":"SEQ_05812","a":"P50851","g":"LRBA","d":"Lipopolysaccharide-responsive and beige-like anchor protein","L":2863,"m":[{"c":"xxxxx[FVA]xxφ(x){2,10}[YCG][ILY]φxxxxxxxxφxφxx","u":"27-35","sp":"dispersed","x":"structured_like","cf":"high","why":"Six consecutive C-terminal beta-propeller-like repeats (residues 2596-2850) separated by variable 2-24 aa inter-blade linkers, each combining a conserved 9-aa N-terminal turn/beta-strand (GH/DD/DA-like turn + [FVA]xxφ) and a 16-aa C-terminal strand-turn-strand block ([YCG][ILY]φ motif, G/D/E/N-rich tight turn, and hydrophobic C-terminal strand) across a 2-10 aa internal loop.","i":[[2596,2624,"VHSQCFVITSDNRYILVCGFWDKSFRVYS"],[2636,2670,"GHWDVVTCLARSESYIGGNCYILSGSRDATLLLWY"],[2695,2725,"GHDYEVTCAAVCAELGLVLSGSQEGPCLIHS"],[2750,2776,"REGHCVIFYENGLFCTFSVNGKLQATM"],[2779,2808,"DDNIRAIQLSRDGQYLLTGGDRGVVVVRQV"],[2821,2850,"DAGIRAMALSYDQRCIISGMASGSIVLFYN"]]}],"s":"MASEDNRVPSPPPTGDDGGGGGREETPTEGGALSLKPGLPIRGIRMKFAVLTGLVEVGEVSNRDIVETVFNLLVGGQFDLEMNFIIQEGESINCMVDLLEKCDITCQAEVWSMFTAILKKSIRNLQVCTEVGLVEKVLGKIEKVDNMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDKGRWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIAKWPYQNGFTFHTWLRMDPVNNINVDKDKPYLYCFRTSKGLGYSAHFVGGCLIVTSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYNRWKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETADANRVFCGQMTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHKLLLYDGKLSSAIAFTYNPRATDAQLCLESSPKDNPSIFVHSPHALMLQDVKAVLTHSIQSAMHSIGGVQVLFPLFAQLDYRQYLSDEIDLTICSTLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHVSRAVLELCLAFSKYLSNLQNGMPLLKQLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIGTVNIYNTIRRVGTVLLIMHTLKYYYWAVNPQDRSGITPKGLDGPRPNQKEMLSLRAFLLMFIKQLVMKDSGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALMSEHPNSMIPAFDQRNGLRVIYKLLASKSEGIRVQALKAMGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLITMTTYNVLFEILIEQIGTQVIHKQHPDPDSSVKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYHAVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFTTNGNENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTASISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTETQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNVATDTERLELKASPNVEAPQPHRHVLEISRQHEQPGQGIAPDAVNGQRRDSRSTVFRIPEFNWSQMHQRLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDNVIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSLGFTEIEAEKSMSSGGILRQCLRLVCAVAVRNCLECQQHSQLKTRGDKALKPMHSLIPLGKSAAKSPVDIVTGGISPVRDLDRLLQDMDINRLRAVVFRDIEDSKQAQFLALAVVYFISVLMVSKYRDILEPQNERHSQSCTETGSENENVSLSEITPAAFSTLTTASVEESESTSSARRRDSGIGEETATGLGSHVEVTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKNDRGNDLDTKATPSVSVSKNVNVKDILRSLVNIPADGVTVDPALLPPACLGALGDLSVEQPVQFRSFDRSVIVAAKKSAVSPSTFNTSIPTNAVSVVSSVDSAQASDMGGESPGSRSSNAKLPSVPTVDSVSQDPVSNMSITERLEHALEKAAPLLREIFVDFAPFLSRTLLGSHGQELLIEGTSLVCMKSSSSVVELVMLLCSQEWQNSIQKNAGLAFIELVNEGRLLSQTMKDHLVRVANEAEFILSRQRAEDIHRHAEFESLCAQYSADKREDEKMCDHLIRAAKYRDHVTATQLIQKIINILTDKHGAWGNSAVSRPLEFWRLDYWEDDLRRRRRFVRNPLGSTHPEATLKTAVEHVCIFKLRENSKATDEDILAKGKQSIRSQALGNQNSENEILLEGDDDTLSSVDEKDLENLAGPVSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANRVAVMFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPRGSAMQVSPLMFTDKAQQDVIMVLKFPSNSPVTHVAANTQPGLATPAVITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIASNTGMHRRQITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGSETAAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAIQLSRDGQYLLTGGDRGVVVVRQVSDLKQLFAYPGCDAGIRAMALSYDQRCIISGMASGSIVLFYNDFNRWHHEYQTRY"},{"id":"SEQ_05813","a":"Q8N157","g":"AHI1","d":"Jouberin","L":1196,"m":[{"c":"xxxxxxxxxx(x){0,6}xxφxxxxx[DTN]xxxxxφx","u":"26-32","sp":"dispersed","x":"structured_like","cf":"high","why":"Seven 26-32 aa beta-propeller-like repeats in the central structured region (residues 608-928) separated by 12-24 aa linkers, anchored by a conserved hydrophobic core position, a [DTN] turn residue (mostly D), and a C-terminal aromatic/aliphatic residue (mostly W/Y).","i":[[608,639,"GERGCFCLDFSHNGRILAAACASRDGYPIILY"],[652,682,"GHLNIIYDLSWSKDDHYILTSSSDGTARIWK"],[695,726,"PHPSFVYTAKFHPAVRELVVTGCYDSMIRIWK"],[742,772,"VHKSFINSLCFDTEGHHMYSGDCTGVIVVWN"],[800,830,"GIPISYLEIHPNGKRLLIHTKDSTLRIMDLR"],[846,871,"KIHSTLTPCGTFLFAGSEDGIVYVWN"],[886,917,"FKSPIRDISYHPFENMVAFCAFGQNEPILLYI"]]},{"c":"PDTIRSNL[HP][YI]ψKETTSDD","u":18,"sp":"tandem","x":"disordered_like","cf":"high","why":"Head-to-tail tandem duplication of an 18-residue motif in the N-terminal disordered region (residues 46-81) with 15 of 18 positions identical (PDTIRSNL...KETTSDD) and conserved aliphatic M/I at position 11.","i":[[46,63,"PDTIRSNLHYMKETTSDD"],[64,81,"PDTIRSNLPHIKETTSDD"]]}],"s":"MPTAESEAKVKTKVRFEELLKTHSDLMREKKKLKKKLVRSEENISPDTIRSNLHYMKETTSDDPDTIRSNLPHIKETTSDDVSAANTNNLKKSTRVTKNKLRNTQLATENPNGDASVEEDKQGKPNKKVIKTVPQLTTQDLKPETPENKVDSTHQKTHTKPQPGVDHQKSEKANEGREETDLEEDEELMQAYQCHVTEEMAKEIKRKIRKKLKEQLTYFPSDTLFHDDKLSSEKRKKKKEVPVFSKAETSTLTISGDTVEGEQKKESSVRSVSSDSHQDDEISSMEQSTEDSMQDDTKPKPKKTKKKTKAVADNNEDVDGDGVHEITSRDSPVYPKCLLDDDLVLGVYIHRTDRLKSDFMISHPMVKIHVVDEHTGQYVKKDDSGRPVSSYYEKENVDYILPIMTQPYDFKQLKSRLPEWEEQIVFNENFPYLLRGSDESPKVILFFEILDFLSVDEIKNNSEVQNQECGFRKIAWAFLKLLGANGNANINSKLRLQLYYPPTKPRSPLSVVEAFEWWSKCPRNHYPSTLYVTVRGLKVPDCIKPSYRSMMALQEEKGKPVHCERHHESSSVDTEPGLEESKEVIKWKRLPGQACRIPNKHLFSLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDSMIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDLEHSVHHWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLRILVARKFVGAANYREKIHSTLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHPFENMVAFCAFGQNEPILLYIYDFHVAQQEAEMFKRYNGTFPLPGIHQSQDALCTCPKLPHQGSFQIDEFVHTESSSTKMQLVKQRLETVTEVIRSCAAKVNKNLSFTSPPAVSSQQSKLKQSNMLTAQEILHQFGFTQTGIISIERKPCNHQVDTAPTVVALYDYTANRSDELTIHRGDIIRVFFKDNEDWWYGSIGKGQEGYFPANHVASETLYQELPPEIKERSPPLSPEEKTKIEKSPAPQKQSINKNKSQDFRLGSESMTHSEMRKEQSHEDQGHIMDTRMRKNKQAGRKVTLIE"},{"id":"SEQ_05817","a":"P18887","g":"XRCC1","d":"DNA repair protein XRCC1","L":633,"m":[{"c":"φφψφxxFxxxxRxxLxxxφx(x){36,38}φVRxxWψφxCxxxx+xLPxQxYxψφ","u":"81-83","sp":"dispersed","x":"structured_like","cf":"high","why":"Two dispersed 81-83 aa globular domain repeats separated by a long disordered linker, sharing a conserved N-terminal hydrophobic-F-R-L segment and a strongly conserved 25-aa C-terminal signature anchored by invariant V, R, W, C, L, P, Q, and Y residues.","i":[[324,404,"VVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLGLGGRIVRKEWVLDCHRMRRRLPSQRYLMA"],[548,630,"FFLYGEFPGDERRKLIRYVTAFNGELEDYMSDRVQFVITAQEWDPSFEEALMDNPSLAFVRPRWIYSCNEKQKLLPHQLYGVV"]]}],"s":"MPEIRLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTISVVLQLEKEEQIHSVDIGNDGSAFVEVLVGSSAGGAGEQDYEVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLVRAAAEKRWDRVKIVCSQPYSKDSPFGLSFVRFHSPPDKDEAEAPSQKVTVTKLGQFRVKEEDESANSLRPGALFFSRINKTSPVTASDPAGPSYAAATLQASSAASSASPVSRAIGSTSKPQESPKGKRKLDLNQEEKKTPSKPPAQLSPSVPKRPKLPAPTRTPATAPVPARAQGAVTGKPRGEGTEPRRPRAGPEELGKILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLGLGGRIVRKEWVLDCHRMRRRLPSQRYLMAGPGSSSEEDEASHSGGSGDEAPKLPQKQPQTKTKPTQAAGPSSPQKPPTPEETKAASPVLQEDIDIEGVQSEGQDNGAEDSGDTEDELRRVAEQKEHRLPPGQEENGEDPYAGSTDENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERRKLIRYVTAFNGELEDYMSDRVQFVITAQEWDPSFEEALMDNPSLAFVRPRWIYSCNEKQKLLPHQLYGVVPQA"},{"id":"SEQ_05828","a":"P10075","g":"GLI4","d":"Zinc finger protein GLI4","L":376,"m":[{"c":"KP[HYF]xCxxCG[KRQ][ASR]FxxxSx[LF]xxH[QLH]RxH[TNY][GR]E","u":28,"sp":"tandem","x":"structured_like","cf":"high","why":"Seven contiguous head-to-tail 28-aa C2H2-type repeats spanning residues 181-376, anchored by invariant K, P, CxxCG, F, S, H, R, H, and E positions and conserved TGE/KP[HYF] inter-unit linkers.","i":[[181,208,"KPHRCEACGKSFKYNSLLLKHQRIHTGE"],[209,236,"KPYACHECGKRFRGWSGFIQHHRIHTGE"],[237,264,"KPYECGQCGRAFSHSSHFTQHLRIHNGE"],[265,292,"KPYKCGECGQAFSQSSNLVRHQRLHTGE"],[293,320,"KPYACSQCGKAFIWSSVLIEHQRIHTGE"],[321,348,"KPYECSDCGKAFRGRSHFFRHLRTHTGE"],[349,376,"KPFACGACGKAFGQSSQLIQHQRVHYRE"]]}],"s":"MAALGDIQESPSVPSPVSLSSPGTPGTQHHEPQLHLHGHQHGSPGSSPKVLSQPSDLDLQDVEEVEIGRDTFWPDSEPKPEQAPRSPGSQAPDEGAGGALRSLLRSLPRRARCSAGFGPESSAERPAGQPPGAVPCAQPRGAWRVTLVQQAAAGPEGAPERAAELGVNFGRSRQGSARGAKPHRCEACGKSFKYNSLLLKHQRIHTGEKPYACHECGKRFRGWSGFIQHHRIHTGEKPYECGQCGRAFSHSSHFTQHLRIHNGEKPYKCGECGQAFSQSSNLVRHQRLHTGEKPYACSQCGKAFIWSSVLIEHQRIHTGEKPYECSDCGKAFRGRSHFFRHLRTHTGEKPFACGACGKAFGQSSQLIQHQRVHYRE"},{"id":"SEQ_05845","a":"Q12906","g":"ILF3","d":"Interleukin enhancer-binding factor 3","L":894,"m":[{"c":"ψMxLN[EQ]x+xGLxYxLψS[EQ]TG[GP]xHxxxFxMxVEVDGoxF[EQ][AG][AS]GxoKKxAKφxφAψxφL[EQ]xψ","u":60,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two gapless 60-residue structured domain repeats separated by a 61-aa proline/alanine-rich linker, sharing 24 identical anchors (including GLxYxL, HxxxfxMxVEVDG, and KKxAK) plus conserved hydrophobic core positions.","i":[[406,465,"LMRLNQLKPGLQYKLVSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDM"],[529,588,"VMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKL"]]},{"c":"[DNS][NS]YNSP","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 6-residue motifs separated by ~59-62 aa linkers within the C-terminal G/S/Y/Q-rich disordered region, anchored by an invariant YNSP core and a constrained polar/acidic N-terminal dinucleotide-like cap ([DNS][NS]).","i":[[720,725,"DNYNSP"],[788,793,"NSYNSP"],[856,861,"SNYNSP"]]}],"s":"MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQAESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKLVSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAEQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLALDANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRGFGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSYYQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKGYNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGYGGGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNYQYR"},{"id":"SEQ_05848","a":"O75526","g":"RBMXL2","d":"RNA-binding motif protein, X-linked-like-2","L":392,"m":[{"c":"RD[GS]Y[SG][GSR]","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Five dispersed copies of a 6-residue motif in the C-terminal R/G/S/Y-enriched disordered region anchored by invariant R1, D2, and aromatic Y4 with constrained small/polar choices at flanking positions.","i":[[187,192,"RDGYSG"],[217,222,"RDGYSS"],[260,265,"RDGYGG"],[323,328,"RDSYSS"],[362,367,"RDSYSR"]]}],"s":"MVEADRPGKLFIGGLNLETDEKALEAEFGKYGRIVEVLLMKDRETNKSRGFAFVTFESPADAKAAARDMNGKSLDGKAIKVAQATKPAFESSRRGPPPPRSRGRPRFLRGTRGGGGGPRRSPSRGGPDDDGGYTADFDLRPSRAPMPMKRGPPPRRVGPPPKRAAPSGPARSSGGGMRGRALAVRGRDGYSGPPRREPLPPRRDPYLGPRDEGYSSRDGYSSRDYREPRGFAPSPGEYTHRDYGHSSVRDDCPLRGYSDRDGYGGRDRDYGDHLSRGSHREPFESYGELRGAAPGRGTPPSYGGGGRYEEYRGYSPDAYSGGRDSYSSSYGRSDRYSRGRHRVGRPDRGLSLSMERGCPPQRDSYSRSGCRVPRGGGRLGGRLERGGGRSRY"},{"id":"SEQ_05858","a":"Q9ULH4","g":"LRFN2","d":"Leucine-rich repeat and fibronectin type-III domain-containing protein 2","L":789,"m":[{"c":"x[LT]xxLx[LV]xxNx[IL]xx[IL]xxxxφ(x){4,5}","u":"24-25","sp":"tandem","x":"structured_like","cf":"high","why":"Seven head-to-tail tandem 24-25 aa structured repeats featuring invariant L5 and N10 anchors and periodic aliphatic/hydrophobic core positions at residues 2, 7, 12, 15, and 20.","i":[[53,76,"RTVELRLGGNFIIHISRQDFANMT"],[77,100,"GLVDLTLSRNTISHIQPFSFLDLE"],[101,124,"SLRSLHLDSNRLPSLGEDTLRGLV"],[125,149,"NLQHLIVNNNQLGGIADEAFEDFLL"],[150,173,"TLEDLDLSYNNLHGLPWDSVRRMV"],[174,197,"NLHQLSLDHNLLDHIAEGTFADLQ"],[198,221,"KLARLDLTSNRLQKLPPDPIFARS"]]}],"s":"METLLGGLLAFGMAFAVVDACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLSFSFGGNPLHCNCELLWLRRLERDDDLETCGSPGGLKGRYFWHVREEEFVCEPPLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLVGNSSRTAVYDNGTLDIFITTSQDSGAFTCIAANAAGEATAMVEVSIVQLPHLSNSTSRTAPPKSRLSDITGSSKTSRGGGGSGGGEPPKSPPERAVLVSEVTTTSALVKWSVSKSAPRVKMYQLQYNCSDDEVLIYRMIPASNKAFVVNNLVSGTGYDLCVLAMWDDTATTLTATNIVGCAQFFTKADYPQCQSMHSQILGGTMILVIGGIIVATLLVFIVILMVRYKVCNHEAPSKMAAAVSNVYSQTNGAQPPPPSSAPAGAPPQGPPKVVVRNELLDFTASLARASDSSSSSSLGSGEAAGLGRAPWRIPPSAPRPKPSLDRLMGAFASLDLKSQRKEELLDSRTPAGRGAGTSARGHHSDREPLLGPPAARARSLLPLPLEGKAKRSHSFDMGDFAAAAAGGVVPGGYSPPRKVSNIWTKRSLSVNGMLLPFEESDLVGARGTFGSSEWVMESTV"},{"id":"SEQ_05871","a":"Q9UHL3","g":"FAM153A","d":"Protein FAM153A","L":310,"m":[{"c":"[GS]DLEDLEEH[GV]P[GE]QTVSEEAT[EG]VH[TM]M[EQ][GV]DP[DA]TLA[EK]","u":34,"sp":"dispersed","x":"mixed","cf":"high","why":"Three highly conserved 34-aa repeats with 25 strictly invariant positions across all copies (including DLEDLEEH, QTVSEEAT, VH, M, DP, and TLA), with copy 1 separated by a 32-aa linker and copies 2-3 arranged head-to-tail.","i":[[111,144,"GDLEDLEEHGPGQTVSEEATEVHTMEGDPDTLAE"],[177,210,"GDLEDLEEHVPGQTVSEEATGVHMMQVDPATLAK"],[211,244,"SDLEDLEEHVPEQTVSEEATGVHMMQVDPATLAK"]]}],"s":"MVDKDTERDIEMKRQLRRLRELHLYSTWKKYQEAMKTSLGVPQCERDEGSLGKPLCPPEILSETLPGSVKKRVCFPSEDHLEEFIAEHLPEASNQSLLTVAHADAGTQTNGDLEDLEEHGPGQTVSEEATEVHTMEGDPDTLAEFLIRDVLQELSSYNGEEEDPEEVKTSLGVPQRGDLEDLEEHVPGQTVSEEATGVHMMQVDPATLAKSDLEDLEEHVPEQTVSEEATGVHMMQVDPATLAKQLEDSTITGSHQQMSASPSSAPAEEATEKTKVEEEVKTRKPKKKTRKPSKKSRWNVLKCWDIFNIF"},{"id":"SEQ_05887","a":"A5D8V6","g":"VPS37C","d":"Vacuolar protein sorting-associated protein 37C","L":355,"m":[{"c":"P[GP]YPx","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Six dispersed copies of a proline-aromatic P[GP]YPx motif (three PPYPx and three PGYPx units, alongside related PTYP/PPYG variants) recur across the C-terminal P/G/Y-rich disordered region.","i":[[201,205,"PPYPL"],[270,274,"PGYPG"],[282,286,"PGYPL"],[294,298,"PGYPQ"],[309,313,"PPYPI"],[332,336,"PPYPP"]]}],"s":"METLKDKTLQELEELQNDSEAIDQLALESPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDRYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQVEGMKIEEESEAMAEKFLEGEVPLETFLENFSSMRMLSHLRRVRVEKLQEVVRKPRASQELAGDAPPPRPPPPVRPVPQGTPPVVEEQPQPPLAMPPYPLPYSPSPSLPVGPTAHGALPPAPFPVVSQPSFYSGPLGPTYPAAQLGPRGAAGYSWSPQRSMPPRPGYPGTPMGASGPGYPLRGGRAPSPGYPQQSPYPATGGKPPYPIQPQLPSFPGQPQPSVPLQPPYPPGPAPPYGFPPPPGPAWPGY"},{"id":"SEQ_05894","a":"Q9UBG3","g":"CRNN","d":"Cornulin","L":495,"m":[{"c":"[GT][AP]TQTVEQDSSHQTG[RS]TS[KT]QTQE[AS]TN[DG]QNRGTE[TI]HGQGRSQTSQAVTGGH[AT]QIQAG[TS]HT[QE]","u":60,"sp":"tandem","x":"disordered_like","cf":"high","why":"Two head-to-tail 60-aa tandem repeats in the central Q/T/G/S/H-rich disordered region share 50/60 identical residues (83% sequence identity), flanked by shorter degenerate TVEQD/TREQD remnants.","i":[[237,296,"GATQTVEQDSSHQTGRTSKQTQEATNDQNRGTETHGQGRSQTSQAVTGGHAQIQAGTHTQ"],[297,356,"TPTQTVEQDSSHQTGSTSTQTQESTNGQNRGTEIHGQGRSQTSQAVTGGHTQIQAGSHTE"]]}],"s":"MPQLLQNINGIIEAFRRYARTEGNCTALTRGELKRLLEQEFADVIVKPHDPATVDEVLRLLDEDHTGTVEFKEFLVLVFKVAQACFKTLSESAEGACGSQESGSLHSGASQELGEGQRSGTEVGRAGKGQHYEGSSHRQSQQGSRGQNRPGVQTQGQATGSAWVSSYDRQAESQSQERISPQIQLSGQTEQTQKAGEGKRNQTTEMRPERQPQTREQDRAHQTGETVTGSGTQTQAGATQTVEQDSSHQTGRTSKQTQEATNDQNRGTETHGQGRSQTSQAVTGGHAQIQAGTHTQTPTQTVEQDSSHQTGSTSTQTQESTNGQNRGTEIHGQGRSQTSQAVTGGHTQIQAGSHTETVEQDRSQTVSHGGAREQGQTQTQPGSGQRWMQVSNPEAGETVPGGQAQTGASTESGRQEWSSTHPRRCVTEGQGDRQPTVVGEEWVDDHSRETVILRLDQGNLHTSVSSAQGQDAAQSEEKRGITARELYSYLRSTKP"},{"id":"SEQ_05898","a":"O00512","g":"BCL9","d":"B-cell CLL/lymphoma 9 protein","L":1426,"m":[{"c":"[MQ]QGMMG[PE][QH]","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three C-terminal disordered-region copies sharing an invariant 5-residue QGMMG core flanked by conserved [MQ] and [PE][QH] positions at ~50-60 aa intervals.","i":[[1273,1280,"MQGMMGEQ"],[1323,1330,"QQGMMGPH"],[1384,1391,"MQGMMGPQ"]]},{"c":"[LI]KSPx","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four clustered copies within a 63-residue disordered segment anchored by an aliphatic [LI] residue preceding an invariant KSP motif (absent from the rest of the 1426-aa sequence) and a polar/proline +1 position.","i":[[863,867,"LKSPT"],[883,887,"LKSPQ"],[905,909,"IKSPP"],[921,925,"LKSPS"]]},{"c":"[PA]SSTP[LY]","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three disordered-region copies of an invariant SSTP core anchored N-terminally by [PA] and C-terminally by a bulky hydrophobic/aromatic [LY] residue, with two closely spaced copies at 992-1025 and one N-terminal copy.","i":[[293,298,"ASSTPL"],[988,993,"PSSTPY"],[1019,1024,"PSSTPL"]]}],"s":"MHSSNPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERSISADSFDQRDPGTPNDDSDIKECNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF"},{"id":"SEQ_05917","a":"Q9UL36","g":"ZNF236","d":"Zinc finger protein 236","L":1845,"m":[{"c":"CxxCxxx[FY]xxxxxxxxH(x){3,4}H","u":"21-22","sp":"dispersed","x":"structured_like","cf":"high","why":"30 copies of a 21-22 aa repeat anchored by invariant CxxC, a conserved aromatic [FY] at position 8, a predominantly leucine hydrophobic core position at residue 14, and a C-terminal H(x){3,4}H pair; arranged into six clusters (within which adjacent units are predominantly joined by conserved 7-aa TGEKP[FY]K-like linkers) separated by long disordered linkers.","i":[[39,59,"CEICLLSFPKESQFQRHMRDH"],[68,88,"CDQCPQTFNVEFNLTLHKCTH"],[95,115,"CPVCNKKFSRVASLKAHIMLH"],[123,143,"CSECGDEFTLQSQLAVHMEEH"],[155,175,"CKACKKEFETSSELKEHMKTH"],[199,219,"CPHCGKTFQKPSQLTRHIRIH"],[227,247,"CSECGKAFNQKGALQTHMIKH"],[255,276,"CAFCPAAFSQKGNLQSHVQRVH"],[287,308,"CTECSCVFKSLGSLNTHISKMH"],[484,504,"CPYCAKEFRKPSDLVRHIRIH"],[512,532,"CPQCFRAFAVKSTLTAHIKTH"],[540,560,"CQYCMKSFSTSGSLKVHIRLH"],[568,588,"CPHCDKKFRTSGHRKTHIASH"],[659,679,"CFYCHRAYKKSCHLKQHIRSH"],[687,707,"CSQCGRGFVSAGVLKAHIRTH"],[715,735,"CLICNGAFTTGGSLRRHMGIH"],[743,763,"CPYCQKTFKTSLNCKKHMKTH"],[969,989,"CDYCNKGFKKSSHLKQHVRSH"],[997,1017,"CKLCGRGFVSSGVLKSHEKTH"],[1025,1045,"CSVCNASFTTNGSLTRHMATH"],[1053,1073,"CPFCEEGFRTTVHCKKHMKRH"],[1169,1189,"CTYCPKSFKKPSDLVRHVRIH"],[1197,1217,"CDECGKSFTVKSTLDCHVKTH"],[1225,1245,"CHVCSNAFSTKGSLKVHMRLH"],[1253,1273,"CPHCELRFRTSGRRKTHMQFH"],[1659,1680,"CLECDRAFSSAAVLMHHSKEVH"],[1688,1708,"CPVCRKAFKRATHLKEHMQTH"],[1724,1744,"CDTCEKAFAKPSQLERHSRIH"],[1752,1772,"CTLCEKAFNQKSALQVHMKKH"],[1780,1801,"CAYCVMGFTQKSNMKLHMKRAH"]]}],"s":"MGLCGLLERCWLHHDPDGVLTLNAENTNYAYQVPNFHKCEICLLSFPKESQFQRHMRDHERNDKPHRCDQCPQTFNVEFNLTLHKCTHSGEDPTCPVCNKKFSRVASLKAHIMLHEKEENLICSECGDEFTLQSQLAVHMEEHRQELAGTRQHACKACKKEFETSSELKEHMKTHYKIRVSSTRSYNRNIDRSGFTYSCPHCGKTFQKPSQLTRHIRIHTGERPFKCSECGKAFNQKGALQTHMIKHTGEKPHACAFCPAAFSQKGNLQSHVQRVHSEVKNGPTYNCTECSCVFKSLGSLNTHISKMHMGGPQNSTSSTETAHVLTATLFQTLPLQQTEAQATSASSQPSSQAVSDVIQQLLELSEPAPVESGQSPQPGQQLSITVGINQDILQQALENSGLSSIPAAAHPNDSCHAKTSAPHAQNPDVSSVSNEQTDPTDAEQEKEQESPEKLDKKEKKMIKKKSPFLPGSIREENGVRWHVCPYCAKEFRKPSDLVRHIRIHTHEKPFKCPQCFRAFAVKSTLTAHIKTHTGIKAFKCQYCMKSFSTSGSLKVHIRLHTGVRPFACPHCDKKFRTSGHRKTHIASHFKHTELRKMRHQRKPAKVRVGKTNIPVPDIPLQEPILITDLGLIQPIPKNQFFQSYFNNNFVNEADRPYKCFYCHRAYKKSCHLKQHIRSHTGEKPFKCSQCGRGFVSAGVLKAHIRTHTGLKSFKCLICNGAFTTGGSLRRHMGIHNDLRPYMCPYCQKTFKTSLNCKKHMKTHRYELAQQLQQHQQAASIDDSTVDQQSMQASTQMQVEIESDELPQTAEVVAANPEAMLDLEPQHVVGTEEAGLGQQLADQPLEADEDGFVAPQDPLRGHVDQFEEQSPAQQSFEPAGLPQGFTVTDTYHQQPQFPPVQQLQDSSTLESQALSTSFHQQSLLQAPSSDGMNVTTRLIQESSQEELDLQAQGSQFLEDNEDQSRRSYRCDYCNKGFKKSSHLKQHVRSHTGEKPYKCKLCGRGFVSSGVLKSHEKTHTGVKAFSCSVCNASFTTNGSLTRHMATHMSMKPYKCPFCEEGFRTTVHCKKHMKRHQTVPSAVSATGETEGGDICMEEEEEHSDRNASRKSRPEVITFTEEETAQLAKIRPQESATVSEKVLVQSAAEKDRISELRDKQAELQDEPKHANCCTYCPKSFKKPSDLVRHVRIHTGEKPYKCDECGKSFTVKSTLDCHVKTHTGQKLFSCHVCSNAFSTKGSLKVHMRLHTGAKPFKCPHCELRFRTSGRRKTHMQFHYKPDPKKARKPMTRSSSEGLQPVNLLNSSSTDPNVFIMNNSVLTGQFDQNLLQPGLVGQAILPASVSAGGDLTVSLTDGSLATLEGIQLQLAANLVGPNVQISGIDAASINNITLQIDPSILQQTLQQGNLLAQQLTGEPGLAPQNSSLQTSDSTVPASVVIQPISGLSLQPTVTSANLTIGPLSEQDSVLTTNSSGTQDLTQVMTSQGLVSPSGGPHEITLTINNSSLSQVLAQAAGPTATSSSGSPQEITLTISELNTTSGSLPSTTPMSPSAISTQNLVMSSSGVGGDASVTLTLADTQGMLSGGLDTVTLNITSQGQQFPALLTDPSLSGQGGAGSPQVILVSHTPQSASAACEEIAYQVAGVSGNLAPGNQPEKEGRAHQCLECDRAFSSAAVLMHHSKEVHGRERIHGCPVCRKAFKRATHLKEHMQTHQAGPSLSSQKPRVFKCDTCEKAFAKPSQLERHSRIHTGERPFHCTLCEKAFNQKSALQVHMKKHTGERPYKCAYCVMGFTQKSNMKLHMKRAHSYAGALQESAGHPEQDGEELSRTLHLEEVVQEAAGEWQALTHVF"},{"id":"SEQ_05929","a":"Q5VVP1","g":"SPATA31A6","d":"Spermatogenesis-associated protein 31A6","L":1343,"m":[{"c":"HIxxφφxxH","u":9,"sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed copies in the central region (residues 598-606, 721-729, 799-807) share invariant N-terminal HI and C-terminal H anchors in an amphipathic alpha-helical register (positions 1, 2, 9) flanking a conserved central bulky hydrophobic pair (WI, IL, FW at positions 5-6). Notably, these represent all three HI dipeptides in the 1343-residue protein and each is immediately followed by a Gly/Leu-containing C-capping turn (WGNLG, MGRNLG, RWGLP).","i":[[598,606,"HIKKWIIQH"],[721,729,"HIENILKAH"],[799,807,"HIVRFWAKH"]]}],"s":"MENLPFPLKLLSASSLNAPSSTPWVLDIFLTLVFALGFFFLLLPYLSYFHCDDPPSPSPGKRKCPVGRRRRPRGRMKNHSLRAGRECPRGLEETSDLLSQLQSLLGPHLDKGDFGQLSGPDPPGEVGERAPDGASQSSHEPMEDAAPILSPLASPDPQAKHPQDLASTPSPGPMTTSVSSLSASQPPEPSLPLEHPSPEPPALFPHPPHTPDPLACSPPPPKGFTAPPLRDSTLITPSHCDSVALPLGTVPQSLSPHEDLVASVPAISGLGGSNSHVSASSRWQETARTSCAFNSSVQQDPLSRHPPETCQMEAGSLFLLSSDGQNVVGIQVTETAKVNIWEEKENVGSFTNQMTPEKHLNSLGNLAKSLDAEQDTTNPKPFWNMGENSKQLPGPQKCSDPRLLQESFWKNYSQLFWGLPSLHSESLVANAWVTDRSYTLQSPPFLFNEMSNVCPIQRETTMSPLLFQAQPLSHRQPFISSTPQFLPTPMAQAEAQAHLQSSFPVLSPAFPSLIKNTGVACPASQNKVQALSLPETQHPEWPLLRKQLEGRLALPSRVQKSQDVFSVSTPNLPQESLTSILPENFPVSPELRRQLEQHIKKWIIQHWGNLGRIQESLDLMQLRDESPGTSQAKGKPSPWQSSTSTGESSKEAQKVKFQLERDLCPHLGQILGETPQNLSRDMKSFPRKVLGVTSEESERNLRKPLRSDSGSDLLRCTERTHIENILKAHMGRNLGQTNEGLIPVRVRRSWLAVNQALPVSNTHVKTSNLAAPKSGKACVNTAQVLSFLEPCTQQGLGAHIVRFWAKHRWGLPLRVLKPIQCFKLEKVSSLSLTQLAGPSSATCESGAGSEVEVDMFLRKPPMASLRKQVLTKASDHMPESLLASSPAWKQFQRAPRGIPSWNDHGPLKPPPAGQEGRWPSKPLTYSLTGSTQQSRSLGAQSSKAGETREAVPQCRVPLETCMLANLQATSEDVHGFEAPGTSKSSLHPRVSVSQDPRKLCLMEEVVSEFEPGMATKSETQPQVCAAVVLLPDGQASVVPHASENLVSQVPQGHLQSMPTGNMRASQELHDLMAARRSKLVQEEPRNPNCQGSCKSQRPMFPPIHKSEKSRKPNLEKHEERLEGLRTPQLTPVRKTEDTHQDEGVQLLPSKKQPPSVSHFGENIKQFFQWIFSKKKSKPAPVTAESQKTVKNRSCVYSSSAEAQGLMTAVGQMLDKKMSLCHAHHASKVNQHKQKFQAPVCGFPCNHRHLFYSEHGRILSYAASSQQATLKSQGCPNRDRQIRNQQPLKSVRCNNEQWGLRHPQILHPKKAVSPVSPPQHWPKTSGASSHHHHCPRHCLLWEGI"},{"id":"SEQ_05935","a":"Q6ZS81","g":"WDFY4","d":"WD repeat- and FYVE domain-containing protein 4","L":3184,"m":[{"c":"[AG]ψ[STC][ACL][LIC][ATC]φ(x){5,10}xψψ[STV][GC](x){4,5}ψx[VLC]W","u":"25-31","sp":"dispersed","x":"structured_like","cf":"high","why":"Five C-terminal beta-propeller-like blade cores (aa 2935-3180) share a conserved [AG]-led hydrophobic beta-strand, a 5-10 aa loop, an aliphatic-rich xψψ[STV][GC] strand-turn motif, and an invariant C-terminal W anchor. The cores are separated by variable 16-55 aa inter-blade linkers (including an extended Pro-rich loop preceding the final copy).","i":[[2935,2960,"GRCLCAVCPSPTTIVTSGTSTVVCVW"],[2984,3009,"AVTCLAASVTFSLLVSGSQDCTCILW"],[3026,3050,"GISAITISDVSGTIVSCAGAHLSLW"],[3069,3099,"AITCCCLMEGPAWDTSQIIITGSQDGMVRVW"],[3155,3180,"AVTALAVSRNHTKLLVGDERGRIFCW"]]}],"s":"MEAEDLSKAEDRNEDPGSKNEGQLAAVQPDVPHGGQSSSPTALWDMLERKFLEYQQLTHKSPIERQKSLLSLLPLFLKAWEHSVGIICFPSLQRLAEDVSDQLAQQLQKALVGKPAEQARLAAGQLLWWKGDVDQDGYLLLKSVYVLTGTDSETLGRVAESGLPALLLQCLYLFFVFPLDKDELLESDLQVQKMFVQMLLNICSDSQGLEGLLSGSELQSLLIATTCLREHSCCFWKEPTFCVLRAISKAQNLSIIQYLQATDCVRLSLQNLSRLTDTLPAPEVSEAVSLILGFVKDSYPVSSALFLEFENSEGYPLLLKVLLRYDGLTQSEVDPHLEELLGLVVWLTTCGRSELKVFDSITYPQLEGFKFHHEASGVTVKNLQAFQVLQNVFHKASDSVLCIQVLSVIRTMWAWNARNFFLLEWTLQPISQFVEIMPLKPAPVQEHFFQLLEALVFELHYVPHEILRKVQHLIKESPGPSCTLMALQSILSIAGGDPLFTDIFRDSGLLGLLLAQLRKQAKIMRKSGNKVSTPGVQDPERELTCVMLRIVVTLLKGSVRNAVVLKDHGMVPFIKIFLDDECYREASLSILEQLSAINAEEYMSIIVGALCSSTQGELQLKLDLLKSLLRILVTPKGRAAFRVSSGFNGLLSLLSDLEGSLQEPPLQAWGAVSPRQTLELVLYTLCAVSAALHWDPVNGYFFRRNGLFEKLAEDLCLLGCFGALEEEGNLLRSWVDTKARPFADLLGTAFSSSGSLPPRIQSCLQILGFLDSMASGTLHLRGDLKESLRTKQGPVVDVQKGETGSDPQRNFKQWPDLEERMDEGDAAIMHPGVVCIMVRLLPRLYHEDHPQLSEEIQCSLASHIQSLVKSEKNRQVMCEAGLLGTLMASCHRALVTSGSPLHSRLIRIFEKLASQAIEPDVLRQFLGLGIPSSLSATTKILDSSHTHRGNPGCSGSQTAQGLAEGPWPAAPDAGLHPGVTQAPQPLGESQDSTTALQTALSLISMTSPRNLQPQRAALAPSFVEFDMSVEGYGCLFIPTLSTVMGTSTEYSVSGGIGTGATRPFPPPGGLTFSCWFLISRHGAATEGHPLRFLTLVRHLARTEQPFVCFSVSLCPDDLSLVVSTEEKEFQPLDVMEPEDDSEPSAGCQLQVRCGQLLACGQWHHLAVVVTKEMKRHCTVSTCLDGQVIGSAKMLYIQALPGPFLSMDPSAFVDVYGYIATPRVWKQKSSLIWRLGPTYLFEEAISMETLEVINKLGPRYCGNFQAVHVQGEDLDSEATPFVAEERVSFGLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIGAVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMCDFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCNFELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKISTIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKTIWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLLYFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFLAHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGALLLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAAFPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLGASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQPSAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLSTLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLLLLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQLVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNVAHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQRRKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLEALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSEDFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTGDVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFHNGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQKRDISNFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERKLKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADRMFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWADGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLSSITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFYSLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWGFDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQDGMVRVWKTEDVKMSVPGRPAGEEPPAQPPSPRGHKWEKNLALSRELDVSIALTGKPSKTSPAVTALAVSRNHTKLLVGDERGRIFCWSADG"},{"id":"SEQ_05942","a":"P42768","g":"WAS","d":"Actin nucleation-promoting factor WAS","L":502,"m":[{"c":"Rx[GE][GP]LPP[LVP]P[LP]","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed 10-residue proline-rich motifs in disordered regions anchored by strictly invariant R1, L5, P6, P7, and P9 positions alongside constrained [GE]3, [GP]4, [LVP]8, and [LP]10 choices; remaining unanchored polyproline tracts are excluded as compositional bias.","i":[[170,179,"RRGGLPPLPL"],[309,318,"RQEPLPPPPP"],[338,347,"RSGPLPPVPL"],[377,386,"RSGPLPPPPP"]]}],"s":"MSGGPMGGRPGGRGAPAVQQNIPSTLLQDHENQRLFEMLGRKCLTLATAVVQLYLALPPGAEHWTKEHCGAVCFVKDNPQKSYFIRLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGDDCQAGLNFADEDEAQAFRALVQEKIQKRNQRQSGDRRQLPPPPTPANEERRGGLPPLPLHPGGDQGGPPVGPLSLGLATVDIQNPDITSSRYRGLPAPGPSPADKKRSGKKKISKADIGAPSGFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGLEAVRQEMRRQEPLPPPPPPSRGGNQLPRPPIVGGNKGRSGPLPPVPLGIAPPPPTPRGPPPPGRGGPPPPPPPATGRSGPLPPPPPGAGGPPMPPPPPPPPPPPSSGNGPAPPPLPPALVPAGGLAPGGGRGALLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKRSRAIHSSDEGEDQAGDEDEDDEWDD"},{"id":"SEQ_05944","a":"H3BSY2","g":"GOLGA8M","d":"Golgin subfamily A member 8M","L":632,"m":[{"c":"QEER[IL][RQ][EK]","u":7,"sp":"tandem","x":"structured_like","cf":"medium","why":"Three head-to-tail 7-residue tandem repeats sharing an invariant QEER N-terminal tetrapeptide, an aliphatic [IL]5 anchor, and constrained [RQ]6[EK]7 C-terminal positions (57-86% pairwise identity), sharply conserved beyond the surrounding generic coiled-coil heptad domains.","i":[[339,345,"QEERIRE"],[346,352,"QEERLRK"],[353,359,"QEERIQE"]]}],"s":"MAEETQHNKLAAAKKKLKEYWQKNSPRVPAGANRNRKTNGSIPQTATSGGCQPPGDSATGFHREGPTSSATLKDLESPCQERAVVLDSRSVEISQLKNTIKSLKQQKKQVEHQLEEEKKANNKKQKAKRVLEVQLQTLNIQKEELNTDLYHMKRSLRYFEEKSKDLAVRLQHSLQRKGELESVLSDVMATQKKKANQLSSPSKAGTEWKLEQSMREEALLKVQLTQLKESFQQVQLERDEYSEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQAQVKNNQRISLLNQRQEERIREQEERLRKQEERIQEQHKSLQQLAKPQSVFEEPNNENKSTLQLEQQVKELQEKLGEEHLEAASQQNQQLTAQLSLMALPGEGHGGEHLDSEGEEAPQPMPSVPEDPESREAMSSFMDHLEEKADLSELVKKQELRFIQYWQERCHQKIHHLLSEPGGRAKDAALGGGHHQAGAQGGDEGEAAGAAADGIAAYSNYNNGHRKFLAAAHNSADEPGPGAPAPQELGAADKHGDLCEVSLTSSAQGEAREDPLLDKPTAQPIVQDHQEHPGLGSNCCVPFFCWAWLPRRRR"},{"id":"SEQ_05945","a":"Q7Z3J3","g":"RGPD4","d":"RanBP2-like and GRIP domain-containing protein 4","L":1758,"m":[{"c":"[HY]FEPVVxψP-xVEψxxGEExEKVψΩSxxφxLΩRΩDx-VxQWKERGψG[DN]ψKILxNxxNxxxRψψMRR-QVLKψCANHxITxxMoLxxψxG[ST]-RφWψW[ST]A[SC]DF[SA]DG-xKψE[RH]LAφ+FKxx-ψA-xFKxxF-E","u":130,"sp":"dispersed","x":"structured_like","cf":"high","why":"Ungapped 130-aa internal duplication with >52% sequence identity across two globular-like segments separated by a 167-aa polar linker, anchored by invariant blocks including FEPVV, WKERGψG[DN]ψKIL, MRR-QVLKψCANH, and WψW[ST]A[SC]DF[SA]DG.","i":[[1037,1166,"HFEPVVQMPEKVELVIGEEGEKVLYSQGVKLFRFDAEVRQWKERGLGNLKILKNEVNGKPRMLMRREQVLKVCANHWITTTMNLKPLSGSDRAWMWSASDFSDGDAKLERLAAKFKTPELAEEFKQKFEE"],[1334,1463,"YFEPVVPLPDLVEVSSGEENEKVVFSHRAELYRYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHTITPDMSLQNMKGTERVWVWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDE"]]},{"c":"FxFGx[SKE]","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five dispersed copies of an invariant FxFG core followed by a polar/charged [SKE] position at +6, restricted exclusively to the three S/T/P/K-enriched disordered regions flanking the duplicated structured domain.","i":[[923,928,"FKFGIS"],[984,989,"FQFGKK"],[1283,1288,"FHFGES"],[1539,1544,"FVFGSE"],[1558,1563,"FAFGNS"]]}],"s":"MSCSKAYGERYVASVQGSAPSPRKKSTRGFYFAKLYYEAKEYDLAKKYICTYINVREMDPRAHRFLGLLYELEENTEKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWVERAAKLFPGSPAIYKLKEQLLDCEGEDGWNKLFDLIQSELYVRPDDVHVNIRLVELYRSTKRLKDAVARCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYANLMLLTLSTRDVQESRELLESFDSALQSAKSSLGGNDELSATFLEMKGHFYMHAGSLLLKMGQHGNNVQWRALSELAALCYLIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLNLSRGKQDFLKVVVETFANKSGQSALYDALFSSQSPKDTSFLGSDDIGNIDVQEPELEDLARYDVGAIRAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPQETSRLETNAPESICILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKQLCTERQKSWWDAVCTLIHRKAVPGNSAKLRLLVQHEINTLRAQEKHGLQPALLVHWAKCLQKMGSGLNSFYDQREYIGRSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHVTFAILDAVNGNIEDAMTAFESIKSVVSYWNLALIFHRKAEDIANDALSPEEQEECKNYLRKTRGYLIKILDDSDSNLSVVKKLPVPLESVKEMLKSVMQELENYSEGDPLYKNGSLRNADSEIKHSTPSPTKYSLSPSKSYKYSPKTPPRWAEDQNSLLKMIRQEVKAIKEEMQELKLNSSKSASHHRWPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKESEKPLENDTGFQAQDISGQKNGRGVIFGQTSSTFTFADVAKSTSGEGFQFGKKDPNFKGFSGAGEKLFSSQCGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELVIGEEGEKVLYSQGVKLFRFDAEVRQWKERGLGNLKILKNEVNGKPRMLMRREQVLKVCANHWITTTMNLKPLSGSDRAWMWSASDFSDGDAKLERLAAKFKTPELAEEFKQKFEECQQLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGPTLEWDNCDLREDALDDSVSSSSVHASPLASSPVRKNLFHFGESTTGSNFSFKSALSPSKSPAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEKVVFSHRAELYRYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHTITPDMSLQNMKGTERVWVWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPRESPCGKIAVAVLEETTRERTDVIQGDDVADAASEVEVSSTSETTTKAVVSPPKFVFGSESVKRIFSSEKSKPFAFGNSSATGSLFGFSFNASLKSNNSETSSVAQSGSESKVEPKKCELSKNSDIEQSSDSKVKNLSASFPMEESSINYTFKTPEKEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLREAEATSAVLMEQIKLLKSEIRRLERNQEQEESAANVEHLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQGEE"},{"id":"SEQ_05952","a":"Q96QT6","g":"PHF12","d":"PHD finger protein 12","L":1004,"m":[{"c":"Cx[ST]C(x){5,8}LψxCD[HY]CPφφFHψxCxxPPL[ST](x){4,6}GxWMCxx[CH]","u":"44-45","sp":"dispersed","x":"structured_like","cf":"high","why":"Two dispersed 44-45 aa cysteine/histidine-rich structured repeats (residues 59-102 and 274-318) with conserved Cx[ST]C, LψxCD[HY]CPφφFHψxC, PPL[ST], and GxWMCxx[CH] anchor blocks separated by two short variable loops.","i":[[59,102,"CDSCKEGGDLLCCDHCPAAFHLQCCNPPLSEEMLPPGEWMCHRC"],[274,318,"CFTCNRSCRVAPLIQCDYCPLLFHMDCLEPPLTAMPLGRWMCPNH"]]}],"s":"MWEKMETKTIVYDLDTSGGLMEQIQALLAPPKTDEAEKRSRKPEKEPRRSGRATNHDSCDSCKEGGDLLCCDHCPAAFHLQCCNPPLSEEMLPPGEWMCHRCTVRRKKREQKKELGHVNGLVDKSGKRTTSPSSDTDLLDRSASKTELKAIAHARILERRASRPGTPTSSASTETPTSEQNDVDEDIIDVDEEPVAAEPDYVQPQLRRPFELLIAAAMERNPTQFQLPNELTCTTALPGSSKRRRKEETTGKNVKKTQHELDHNGLVPLPVKVCFTCNRSCRVAPLIQCDYCPLLFHMDCLEPPLTAMPLGRWMCPNHIEHVVLNQKNMTLSNRCQVFDRFQDTVSQHVVKVDFLNRIHKKHPPNRRVLQSVKRRSLKVPDAIKSQYQFPPPLIAPAAIRDGELICNGIPEESQMHLLNSEHLATQAEQQEWLCSVVALQCSILKHLSAKQMPSHWDSEQTEKADIKPVIVTDSSVTTSLQTADKTPTPSHYPLSCPSGISTQNSLSCSPPHQSPALEDIGCSSCAEKSKKTPCGTANGPVNTEVKANGPHLYSSPTDSTDPRRLPGANTPLPGLSHRQGWPRPLTPPAAGGLQNHTVGIIVKTENATGPSSCPQRSLVPVPSLPPSIPSSCASIENTSTLQRKTVQSQIGPPLTDSRPLGSPPNATRVLTPPQAAGDGILATTANQRFSSPAPSSDGKVSPGTLSIGSALTVPSFPANSTAMVDLTNSLRAFMDVNGEIEINMLDEKLIKFLALQRIHQLFPSRVQPSPGSVGTHQLASGGHHIEVQRKEVQARAVFYPLLGLGGAVNMCYRTLYIGTGADMDVCLTNYGHCNYVSGKHACIFYDENTKHYELLNYSEHGTTVDNVLYSCDFSEKTPPTPPSSIVAKVQSVIRRRRHQKQDEEPSEEAAMMSSQAQGPQRRPCNCKASSSSLIGGSGAGWEGTALLHHGSYIKLGCLQFVFSITEFATKQPKGDASLLQDGVLAEKLSLKPHQGPVLRSNSVP"},{"id":"SEQ_05953","a":"Q9P2P6","g":"STARD9","d":"StAR-related lipid transfer protein 9","L":4700,"m":[{"c":"[FL]QPHCE","u":6,"sp":"tandem","x":"disordered_like","cf":"high","why":"Four head-to-tail tandem 6-aa repeats in the central disordered region featuring five invariant residues (QPHCE, including fixed P, H, C, and E anchors) preceded by a conserved bulky hydrophobic residue (F in copy 1, L in copies 2-4).","i":[[1281,1286,"FQPHCE"],[1287,1292,"LQPHCE"],[1293,1298,"LQPHCE"],[1299,1304,"LQPHCE"]]}],"s":"MANVQVAVRVRPLSKRETKEGGRIIVEVDGKVAKIRNLKVDNRPDGFGDSREKVMAFGFDYCYWSVNPEDPQYASQDVVFQDLGMEVLSGVAKGYNICLFAYGQTGSGKTYTMLGTPASVGLTPRICEGLFVREKDCASLPSSCRIKVSFLEIYNERVRDLLKQSGQKKSYTLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIANRITAATHVHEASSRSHAIFTIHYTQAILENNLPSEMASKINLVDLAGSERADPSYCKDRIAEGANINKSLVTLGIVISTLAQNSQVFSSCQSLNSSVSNGGDSGILSSPSGTSSGGAPSRRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYSETMSTLRYASSAKNIINKPRVNEDANLKLIRELREEIERLKALLLSFELRNFSSLSDENLKELVLQNELKIDQLTKDWTQKWNDWQALMEHYSVDINRRRAGVVIDSSLPHLMALEDDVLSTGVVLYHLKEGTTKIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVVLRPARGARCTVNGREVTASCRLTQGAVITLGKAQKFRFNHPAEAAVLRQRRQVGEAAAGRGSLEWLDLDGDLAASRLGLSPLLWKERRALEEQCDEDHQTPRDGETSHRAQIQQQQSYVEDLRHQILAEEIRAAKELEFDQAWISQQIKENQQCLLREETWLASLQQQQQEDQVAEKELEASVALDAWLQTDPEIQPSPFVQSQKRVVHLQLLRRHTLRAAERNVRRKKVSFQLERIIKKQRLLEAQKRLEKLTTLCWLQDDSTQEPPYQVLSPDATVPRPPCRSKLTSCSSLSPQRLCSKHMPQLHSIFLSWDPSTTLPPRPDPTHQTSEKTSSEEHLPQAASYPARTGCLRKNGLHSSGHGQPCTARAALARKGASAPDACLTMSPNSVGIQEMEMGVKQPHQMVSQGLASLRKSANKLKPRHEPKIFTSTTQTRGAKGLADPSHTQAGWRKEGNLGTHKAAKGASCNSLYPHGPRQTAGHGKAVKTFWTEYKPPSPSRASKRHQRVLATRVRNITKKSSHLPLGSPLKRQQNTRDPDTMVPLTDFSPVMDHSREKDNDLSDTDSNYSLDSLSCVYAKALIEPLKPEERKWDFPEPENSESDDSQLSEDSLAEKRYQSPKNRLGGNRPTNNRGQPRTRTRASVRGFTAASDSDLLAQTHRSFSLDSLIDAEEELGEDQQEEPFPGSADEIPTETFWHLEDSSLPVMDQEAICRLGPINYRTAARLDAVLPMSSSFYLDPQFQPHCELQPHCELQPHCELQPHCEQAESQVEPSYSEQADSLQGMQLSRESPLMSMDSWFSCDSKINPSSPPGIVGSLCPSPDMQEFHSCKGERPGYWPNTEELKPSDAETVLPYSSKLHQGSTELLCSARDEHTASAADTSRLSLWGIQRLIQPGADGTFQGRCIPDMTQQGSSEASHNSSVSNVLAASATTLTHVGSTHERDWSALQQKYLLELSCPVLEAIGAPKPAYPYLEEDSGSLAQASSKGGDTLLPVGPRVSSNLNLNNFPVHLSRIRRLRAEKEQDSLNAKLEGVSDFFSTSEKEASYDETYSADLESLSASRSTNAQVFATENAIPDSMTEACEVKQNNLEECLQSCRKPGLMTSSDEDFFQKNACHSNVTTATKADHWSQGWAPLRKNSAVQPGQLSPDSHYPLEEEKTDCQESSKEAVRRHINVSFALPSGPELYLHSAPWNPLSSSLQPPLLETFYVTKSRDALTETALEIPACREVRVPSPPPREAWGFGHNHQALQGAYLKNNLPVLLQNQNSKIASSQQVTAEIPVDLNTREVIRESGKCPGNITEESHDSVYSSVTQNRHFLPSTSTKVCEFENQVVILNKKHSFPALEGGEVTAQSCCGASSDSTESGKSLLFRESEAREEEELDQNTVLRQTINVSLEKDMPGESAVSLKSRSVDRRVSSPVMVAQGGGPTPKWEGKNETGLLEKGLRPKDSSEEFKLPGTKPAYERFQLVACPQERNPSECKSQEMLNPNREPSGKKQNKRVNNTDEMARLIRSVMQLENGILEIESKQNKQVHASHTPGTDKELVFQDQKEQEKTDHAFRPDSSGNPLPSKDQPSSPRQTDDTVFRDSEAGAMEVNSIGNHPQVQKITPNPFRSREGVRESEPVREHTHPAGSDRPARDICDSLGKHTTCREFTNTSLHPQRMKALARALPLQPRLERSSKNNGQFVKASASLKGQPWGLGSLEELETVKGFQESQVAEHVSSSNQEEPKAQGKVEEMPMQRGGSLQEENKVTQKFPSLSQLCRDTFFRQETVSPLLSRTEFCTAPLHQDLSNTLPLNSPRWPRRCLHVPVALGISSLDCVLDLTMLKIHNSPLVTGVEHQDQSTETRSHSPEGNVRGRSSEAHTAWCGSVRSMAMGSHSQSGVPESIPLGTEDRISASTSPQDHGKDLRITLLGFSTSEDFASEAEVAVQKEIRVSSLNKVSSQPEKRVSFSLEEDSDQASKPRQKAEKETEDVGLTSGVSLAPVSLPRVPSPEPRLLEPSDHASMCLAILEEIRQAKAQRKQLHDFVARGTVLSYCETLLEPECSSRVAGRPQCKQIDQSSSDQTRNEGEAPGFHVASLSAEAGQIDLLPDERKVQATSLSADSFESLPNTETDREPWDPVQAFSHAAPAQDRKRRTGELRQFAGASEPFICHSSSSEIIEKKKDATRTPSSADPLAPDSPRSSAPVEEVRRVVSKKVVAALPSQAPYDDPRVTLHELSQSVPQETAEGIPPGSQDSSPEHQEPRTLDTTYGEVSDNLLVTAQGEKTAHFESQSVTCDVQNSTSASGPKQDHVQCPEASTGFEEGRASPKQDTILPGALTRVALEAPTQQCVQCKESVGSGLTEVCRAGSKHSRPIPLPDQRPSANPGGIGEEAPCRHPREALDGPVFSRNPEGSRTLSPSRGKESRTLPCRQPCSSQPVATHAYSSHSSTLLCFRDGDLGKEPFKAAPHTIHPPCVVPSRAYEMDETGEISRGPDVHLTHGLEPKDVNREFRLTESSTCEPSTVAAVLSRAQGCRSPSAPDVRTGSFSHSATDGSVGLIGVPEKKVAEKQASTELEAASFPAGMYSEPLRQFRDSSVGDQNAQVCQTNPEPPATTQGPHTLDLSEGSAESKLVVEPQHECLENTTRCFLEKPQFSTELRDHNRLDSQAKFVARLKHTCSPQEDSPWQEEEQHRDQASGGGEGFAQGVNPLPDEDGLDGCQILDAGREEVAVAKPPVSKILSQGFKDPATVSLRQNETPQPAAQRSGHLYTGREQPAPNHRGSLPVTTIFSGPKHSRSSPTPQFSVVGSSRSLQELNLSVEPPSPTDEDTQGPNRLWNPHLRGYSSGKSVARTSLQAEDSNQKASSRLDDGTTDHRHLKPATPPYPMPSTLSHMPTPDFTTSWMSGTLEQAQQGKREKLGVQVRPENWCSQMDKGMLHFGSSDISPYALPWRPEEPARISWKQYMSGSAVDVSCSQKPQGLTLSNVARCSSMDNGLEDQNSPFHSHLSTYANICDLSTTHSSTENAQGSNEAWEVFRGSSSIALGDPHIPTSPEGVAPTSGHDRRPQFRGPSGEADCLRSKPPLAKGSAAGPVDEIMLLYPSEAGCPVGQTRTNTFEQGTQTLGSRRHWSSTDISFAQPEASAVSAFDLASWTSMHNLSLHLSQLLHSTSELLGSLSQPDVARREQNTKRDIPDKAPQALMMDGSTQTTVDEGSQTDLTLPTLCLQTSEAEPQGANVILEGLGSDTSTVSQEEGDVPGVPQKREAEETAQKMAQLLYLQEESTPYKPQSPSIPSSHLRFQKAPVGQHLPSVSPSVSDAFLPPSSQPEESYCLVVSSPSPSSPHSPGLFPSTSEYPGDSRVQKKLGPTSALFVDRASSPILTLSASTQEPGLSPGSLTLSAPSTHPVEGHQKLDSSPDPVDAPRTPMDNYSQTTDELGGSQRGRSSLQRSNGRSFLELHSPHSPQQSPKLQFSFLGQHPQQLQPRTTIGVQSRLLPPPLRHRSQRLGNSFVPEKVASPEHCPLSGREPSQWQSRTENGGESSASPGEPQRTLDRPSSWGGLQHLSPCPVSELTDTAGLRGSALGLPQACQPEELLCFSCQMCMAPEHQHHSLRDLPVHNKFSNWCGVQKGSPGGLDMTEEELGASGDLSSEKQEQSPPQPPNDHSQDSEWSKREQIPLQVGAQNLSLSVELTEAKLHHGFGEADALLQVLQSGTGEALAADEPVTSTWKELYARQKKAIETLRRERAERLGNFCRTRSLSPQKQLSLLPNKDLFIWDLDLPSRRREYLQQLRKDVVETTRSPESVSRSAHTPSDIELMLQDYQQAHEEAKVEIARARDQLRERTEQEKLRIHQKIISQLLKEEDKLHTLANSSSLCTSSNGSLSSGMTSGYNSSPALSGQLQFPENMGHTNLPDSRDVWIGDERGGHSAVRKNSAYSHRASLGSCCCSPSSLSSLGTCFSSSYQDLAKHVVDTSMADVMAACSDNLHNLFSCQATAGWNYQGEEQAVQLYYKVFSPTRHGFLGAGVVSQPLSRVWAAVSDPTVWPLYYKPIQTARLHQRVTNSISLVYLVCNTTLCALKQPRDFCCVCVEAKEGHLSVMAAQSVYDTSMPRPSRKMVRGEILPSAWILQPITVEGKEVTRVIYLAQVELGAPGFPPQLLSSFIKRQPLVIARLASFLGR"},{"id":"SEQ_05957","a":"Q569K6","g":"CCDC157","d":"Coiled-coil domain-containing protein 157","L":752,"m":[{"c":"QPC[TS][SQ]P[PS]+","u":8,"sp":"tandem","x":"disordered_like","cf":"high","why":"Five head-to-tail tandem octapeptide repeats in the C-terminal P/S-rich disordered region anchored by an invariant QPC N-terminal triad, a fixed P at position 6, and a C-terminal basic residue (R/K).","i":[[668,675,"QPCTSPPR"],[676,683,"QPCTSPPR"],[684,691,"QPCTSPPR"],[692,699,"QPCTSPSR"],[700,707,"QPCSQPSK"]]}],"s":"MAHLLGSQACMESLRTDLTDLQGAIVDVFSRAGPVRFPSWKFPDRMACDLDMVALLEHYDHVPGDPEFTQLSHAVLLELVIDRLLLLLQSCMSYLENLGSEQMMPPAQAAGPCMSVGLTVRRFWDSLLRLGTLHQQPLPQKGANQRETPTSKPTTKGEPARSPEYLTTKLIKPSSPVLGLPQTCQEPESIPVRASLQFPATTFKNTRSVHSQTIETALVPCDACASVQGSLQKVGKVVISLCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQSNDIRIRVLQEENGRLQSMLSKIREVAQQGGLKLIPQDRLWSPSSKGTQGATPPVQAKSTSPGPLGRQHLPSSRTGRTLLGQPCTSPPRQPCTSPPRQPCTSPPRQPCTSPSRQPCSQPSKSLLEGVTHLDTCTQNPIKVLVRLRKRLSPGRGQASSAHQPQERPM"},{"id":"SEQ_05958","a":"P52948","g":"NUP98","d":"Nuclear pore complex protein Nup98-Nup96","L":1817,"m":[{"c":"[GT]GLFGo","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Eight dispersed hexapeptide repeats across the N-terminal T/S/N/Q/G-enriched disordered region featuring an invariant GLFG hydrophobic-glycine core flanked N-terminally by G/T and C-terminally by a polar uncharged residue (S/T/N/Q).","i":[[49,54,"GGLFGN"],[60,65,"GGLFGT"],[127,132,"GGLFGT"],[225,230,"TGLFGS"],[271,276,"GGLFGQ"],[328,333,"GGLFGT"],[347,352,"TGLFGQ"],[388,393,"GGLFGN"]]}],"s":"MFNKSFGTPFGGGTGGFGTTSTFGQNTGFGTTSGGAFGTSAFGSSNNTGGLFGNSQTKPGGLFGTSSFSQPATSTSTGFGFGTSTGTANTLFGTASTGTSLFSSQNNAFAQNKPTGFGNFGTSTSSGGLFGTTNTTSNPFGSTSGSLFGPSSFTAAPTGTTIKFNPPTGTDTMVKAGVSTNISTKHQCITAMKEYESKSLEELRLEDYQANRKGPQNQVGAGTTTGLFGSSPATSSATGLFSSSTTNSGFAYGQNKTAFGTSTTGFGTNPGGLFGQQNQQTTSLFSKPFGQATTTQNTGFSFGNTSTIGQPSTNTMGLFGVTQASQPGGLFGTATNTSTGTAFGTGTGLFGQTNTGFGAVGSTLFGNNKLTTFGSSTTSAPSFGTTSGGLFGNKPTLTLGTNTNTSNFGFGTNTSGNSIFGSKPAPGTLGTGLGAGFGTALGAGQASLFGNNQPKIGGPLGTGAFGAPGFNTTTATLGFGAPQAPVALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSDPKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSSEETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVLDTMLEESMPEDQEPVSASTHIASSLGINPHVLQIMKASLLTDEEDVDMALDQRFSRLPSKADTSQEICSPRLPISASHSSKTRSLVGGLLQSKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMGRSFRVGWGPNWTLANSGEQLNGSHELENHQIADSMEFGFLPNPVAVKPLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIVKHWSLTWTLCEALWGHLKELDSQLNEPREYIQILERRRAFSRWLSCTATPQIEEEVSLTQKNSPVEAVFSYLTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLVDWHQLQADSFIQDERLRIFALLAGKPVWQLSEKKQINVCSQLDWKRSLAIHLWYLLPPTASISRALSMYEEAFQNTSDSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKLYSDRHYDLNQLLEPRSITADPLDYRLSWHLWEVLRALNYTHLSAQCEGVLQASYAGQLESEGLWEWAIFVLLHIDNSGIREKAVRELLTRHCQLLETPESWAKETFLTQKLRVPAKWIHEAKAVRAHMESDKHLEALCLFKAEHWNRCHKLIIRHLASDAIINENYDYLKGFLEDLAPPERSSLIQDWETSGLVYLDYIRVIEMLRHIQQVDCSGNDLEQLHIKVTSLCSRIEQIQCYSAKDRLAQSDMAKRVANLLRVVLSLHHPPDRTSDSTPDPQRVPLRLLAPHIGRLPMPEDYAMDELRSLTQSYLRELAVGSL"},{"id":"SEQ_05965","a":"P98161","g":"PKD1","d":"Polycystin-1","L":4303,"m":[{"c":"xψxGψxψx(x){20,29}φxΩx[WL][DT]FG[DE]G(x){13,31}HxΩxxxGxΩxψxψxAxNxx[SAG](x){6,8}xφxφ[EQ]","u":"82-111","sp":"tandem","x":"structured_like","cf":"high","why":"Sixteen ~85 aa structured beta-sandwich repeats (1 upstream copy at 270-353 and 15 consecutive head-to-tail tandem copies at 820-2145; two copies carry ~20 aa internal loop insertions) anchored by N-terminal PVxGL, a central W[DT]FG[DE]G turn, HxΩxxxGxΩxψxψxAxNxx[SAG] core strands, and a C-terminal xφxφ[EQ] beta-strand.","i":[[270,353,"PASPGATLVGPHGPLASGQLAAFHIAAPLPVTATRWDFGDGSAEVDAAGPAASHRYVLPGRYHVTAVLALGAGSALLGTDVQVE"],[820,930,"PVAGLRVIYPAPRDGRLYVPTNGSALVLQVDSGANATATARWPGGSVSARFENVCPALVATFVPGCPWETNDTLFSVVALPWLSEGEHVVDVVVENSASRANLSLRVTAEE"],[931,1015,"PICGLRATPSPEARVLQGVLVRYSPVVEAGSDMVFRWTINDKQSLTFQNVVFNVIYQSAAVFKLSLTASNHVSNVTVNYNVTVER"],[1018,1124,"RMQGLQVSTVPAVLSPNATLALTAGVLVDSAVEVAFLWTFGDGEQALHQFQPPYNESFPVPDPSVAQVLVEHNVMHTYAAPGEYLLTVLASNAFENLTQQVPVSVRA"],[1125,1210,"SLPSVAVGVSDGVLVAGRPVTFYPHPLPSPGGVLYTWDFGDGSPVLTQSQPAANHTYASRGTYHVRLEVNNTVSGAAAQADVRVFE"],[1211,1295,"ELRGLSVDMSLAVEQGAPVVVSAAVQTGDNITWTFDMGDGTVLSGPEATVEHVYLRAQNCTVTVGAASPAGHLARSLHVLVFVLE"],[1296,1377,"VLRVEPAACIPTQPDARLTAYVTGNPAHYLFDWTFGDGSSNTTVRGCPTVTHNFTRSGTFPLALVLSSRVNRAHYFTSICVE"],[1378,1464,"PEVGNVTLQPERQFVQLGDEAWLVACAWPPFPYRYTWDFGTEEAAPTRARGPEVTFIYRDPGSYLVTVTASNNISAANDSALVEVQE"],[1465,1546,"PVLVTSIKVNGSLGLELQQPYLFSAVGRGRPASYLWDLGDGGWLEGPEVTHAYNSTGDFTVRVAGWNEVSRSEAWLNVTVKR"],[1547,1630,"RVRGLVVNASRTVVPLNGSVSFSTSLEAGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFVYVLQ"],[1631,1716,"LIEGLQVVGGGRYFPTNHTVQLQAVVRDGTNVSYSWTAWRDRGPALAGSGKGFSLTVLEAGTYHVQLRATNMLGSAWADCTMDFVE"],[1717,1800,"PVGWLMVAASPNPAAVNTSVTLSAELAGGSGVVYTWSLEEGLSWETSEPFTTHSFPTPGLHLVTMTAGNPLGSANATVEVDVQV"],[1801,1885,"PVSGLSIRASEPGGSFVAAGSSVPFWGQLATGTNVSWCWAVPGGSSKRGPHVTMVFPDAGTFSIRLNASNAVSWVSATYNLTAEE"],[1886,1969,"PIVGLVLWASSKVVAPGQLVHFQILLAAGSAVTFRLQVGGANPEVLPGPRFSHSFPRVGDHVVSVRGKNHVSWAQAQVRIVVLE"],[1970,2059,"AVSGLQVPNCCEPGIATGTERNFTARVQRGSRVAYAWYFSLQKVQGDSLVILSGRDVTYTPVAAGLLEIQVRAFNALGSENRTLVLEVQD"],[2060,2145,"AVQYVALQSGPCFTNRSAQFEAATSPSPRRVAYHWDFGDGSPGQDTDEPRAEHSYLRPGDYRVQVNASNLVSFFVAQATVTVQVLA"]]},{"c":"[RS][TA]L[GDE]x[AG]ψx(x){0,1}[IN][PL]xxφ[TAS][AE]ψ[DN]ψSxNxφ","u":"23-24","sp":"tandem","x":"structured_like","cf":"high","why":"Three contiguous N-terminal 23-24 aa leucine-rich repeats (residues 57-127) anchored by invariant L at position 3, S at position 20, and N at position 22 alongside phased aliphatic/hydrophobic core positions (ψ[DN]ψSxNxφ).","i":[[57,79,"RTLGPALRIPADATALDVSHNLL"],[80,103,"RALDVGLLANLSALAELDISNNKI"],[104,127,"STLEEGIFANLFNLSEINLSGNPF"]]}],"s":"MPPAAPARLALALGLGLWLGALAGGPGRGCGPCEPPCLCGPAPGAACRVNCSGRGLRTLGPALRIPADATALDVSHNLLRALDVGLLANLSALAELDISNNKISTLEEGIFANLFNLSEINLSGNPFECDCGLAWLPRWAEEQQVRVVQPEAATCAGPGSLAGQPLLGIPLLDSGCGEEYVACLPDNSSGTVAAVSFSAAHEGLLQPEACSAFCFSTGQGLAALSEQGWCLCGAAQPSSASFACLSLCSGPPPPPAPTCRGPTLLQHVFPASPGATLVGPHGPLASGQLAAFHIAAPLPVTATRWDFGDGSAEVDAAGPAASHRYVLPGRYHVTAVLALGAGSALLGTDVQVEAAPAALELVCPSSVQSDESLDLSIQNRGGSGLEAAYSIVALGEEPARAVHPLCPSDTEIFPGNGHCYRLVVEKAAWLQAQEQCQAWAGAALAMVDSPAVQRFLVSRVTRSLDVWIGFSTVQGVEVGPAPQGEAFSLESCQNWLPGEPHPATAEHCVRLGPTGWCNTDLCSAPHSYVCELQPGGPVQDAENLLVGAPSGDLQGPLTPLAQQDGLSAPHEPVEVMVFPGLRLSREAFLTTAEFGTQELRRPAQLRLQVYRLLSTAGTPENGSEPESRSPDNRTQLAPACMPGGRWCPGANICLPLDASCHPQACANGCTSGPGLPGAPYALWREFLFSVPAGPPAQYSVTLHGQDVLMLPGDLVGLQHDAGPGALLHCSPAPGHPGPRAPYLSANASSWLPHLPAQLEGTWACPACALRLLAATEQLTVLLGLRPNPGLRLPGRYEVRAEVGNGVSRHNLSCSFDVVSPVAGLRVIYPAPRDGRLYVPTNGSALVLQVDSGANATATARWPGGSVSARFENVCPALVATFVPGCPWETNDTLFSVVALPWLSEGEHVVDVVVENSASRANLSLRVTAEEPICGLRATPSPEARVLQGVLVRYSPVVEAGSDMVFRWTINDKQSLTFQNVVFNVIYQSAAVFKLSLTASNHVSNVTVNYNVTVERMNRMQGLQVSTVPAVLSPNATLALTAGVLVDSAVEVAFLWTFGDGEQALHQFQPPYNESFPVPDPSVAQVLVEHNVMHTYAAPGEYLLTVLASNAFENLTQQVPVSVRASLPSVAVGVSDGVLVAGRPVTFYPHPLPSPGGVLYTWDFGDGSPVLTQSQPAANHTYASRGTYHVRLEVNNTVSGAAAQADVRVFEELRGLSVDMSLAVEQGAPVVVSAAVQTGDNITWTFDMGDGTVLSGPEATVEHVYLRAQNCTVTVGAASPAGHLARSLHVLVFVLEVLRVEPAACIPTQPDARLTAYVTGNPAHYLFDWTFGDGSSNTTVRGCPTVTHNFTRSGTFPLALVLSSRVNRAHYFTSICVEPEVGNVTLQPERQFVQLGDEAWLVACAWPPFPYRYTWDFGTEEAAPTRARGPEVTFIYRDPGSYLVTVTASNNISAANDSALVEVQEPVLVTSIKVNGSLGLELQQPYLFSAVGRGRPASYLWDLGDGGWLEGPEVTHAYNSTGDFTVRVAGWNEVSRSEAWLNVTVKRRVRGLVVNASRTVVPLNGSVSFSTSLEAGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFVYVLQLIEGLQVVGGGRYFPTNHTVQLQAVVRDGTNVSYSWTAWRDRGPALAGSGKGFSLTVLEAGTYHVQLRATNMLGSAWADCTMDFVEPVGWLMVAASPNPAAVNTSVTLSAELAGGSGVVYTWSLEEGLSWETSEPFTTHSFPTPGLHLVTMTAGNPLGSANATVEVDVQVPVSGLSIRASEPGGSFVAAGSSVPFWGQLATGTNVSWCWAVPGGSSKRGPHVTMVFPDAGTFSIRLNASNAVSWVSATYNLTAEEPIVGLVLWASSKVVAPGQLVHFQILLAAGSAVTFRLQVGGANPEVLPGPRFSHSFPRVGDHVVSVRGKNHVSWAQAQVRIVVLEAVSGLQVPNCCEPGIATGTERNFTARVQRGSRVAYAWYFSLQKVQGDSLVILSGRDVTYTPVAAGLLEIQVRAFNALGSENRTLVLEVQDAVQYVALQSGPCFTNRSAQFEAATSPSPRRVAYHWDFGDGSPGQDTDEPRAEHSYLRPGDYRVQVNASNLVSFFVAQATVTVQVLACREPEVDVVLPLQVLMRRSQRNYLEAHVDLRDCVTYQTEYRWEVYRTASCQRPGRPARVALPGVDVSRPRLVLPRLALPVGHYCFVFVVSFGDTPLTQSIQANVTVAPERLVPIIEGGSYRVWSDTRDLVLDGSESYDPNLEDGDQTPLSFHWACVASTQREAGGCALNFGPRGSSTVTIPRERLAAGVEYTFSLTVWKAGRKEEATNQTVLIRSGRVPIVSLECVSCKAQAVYEVSRSSYVYLEGRCLNCSSGSKRGRWAARTFSNKTLVLDETTTSTGSAGMRLVLRRGVLRDGEGYTFTLTVLGRSGEEEGCASIRLSPNRPPLGGSCRLFPLGAVHALTTKVHFECTGWHDAEDAGAPLVYALLLRRCRQGHCEEFCVYKGSLSSYGAVLPPGFRPHFEVGLAVVVQDQLGAAVVALNRSLAITLPEPNGSATGLTVWLHGLTASVLPGLLRQADPQHVIEYSLALVTVLNEYERALDVAAEPKHERQHRAQIRKNITETLVSLRVHTVDDIQQIAAALAQCMGPSRELVCRSCLKQTLHKLEAMMLILQAETTAGTVTPTAIGDSILNITGDLIHLASSDVRAPQPSELGAESPSRMVASQAYNLTSALMRILMRSRVLNEEPLTLAGEEIVAQGKRSDPRSLLCYGGAPGPGCHFSIPEAFSGALANLSDVVQLIFLVDSNPFPFGYISNYTVSTKVASMAFQTQAGAQIPIERLASERAITVKVPNNSDWAARGHRSSANSANSVVVQPQASVGAVVTLDSSNPAAGLHLQLNYTLLDGHYLSEEPEPYLAVYLHSEPRPNEHNCSASRRIRPESLQGADHRPYTFFISPGSRDPAGSYHLNLSSHFRWSALQVSVGLYTSLCQYFSEEDMVWRTEGLLPLEETSPRQAVCLTRHLTAFGASLFVPPSHVRFVFPEPTADVNYIVMLTCAVCLVTYMVMAAILHKLDQLDASRGRAIPFCGQRGRFKYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRAFHRNSLDIFRIATPHSLGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVEKEVLAASDAALLRFRRLLVAELQRGFFDKHIWLSIWDRPPRSRFTRIQRATCCVLLICLFLGANAVWYGAVGDSAYSTGHVSRLSPLSVDTVAVGLVSSVVVYPVYLAILFLFRMSRSKVAGSPSPTPAGQQVLDIDSCLDSSVLDSSFLTFSGLHAEQAFVGQMKSDLFLDDSKSLVCWPSGEGTLSWPDLLSDPSIVGSNLRQLARGQAGHGLGPEEDGFSLASPYSPAKSFSASDEDLIQQVLAEGVSSPAPTQDTHMETDLLSSLSSTPGEKTETLALQRLGELGPPSPGLNWEQPQAARLSRTGLVEGLRKRLLPAWCASLAHGLSLLLVAVAVAVSGWVGASFPPGVSVAWLLSSSASFLASFLGWEPLKVLLEALYFSLVAKRLHPDEDDTLVESPAVTPVSARVPRVRPPHGFALFLAKEEARKVKRLHGMLRSLLVYMLFLLVTLLASYGDASCHGHAYRLQSAIKQELHSRAFLAITRSEELWPWMAHVLLPYVHGNQSSPELGPPRLRQVRLQEALYPDPPGPRVHTCSAAGGFSTSDYDVGWESPHNGSGTWAYSAPDLLGAWSWGSCAVYDSGGYVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFLELTRYSPAVGLHAAVTLRLEFPAAGRALAALSVRPFALRRLSAGLSLPLLTSVCLLLFAVHFAVAEARTWHREGRWRVLRLGAWARWLLVALTAATALVRLAQLGAADRQWTRFVRGRPRRFTSFDQVAQLSSAARGLAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLAILLVSSCVDSLWSVAQALLVLCPGTGLSTLCPAESWHLSPLLCVGLWALRLWGALRLGAVILRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGLSKVKEFRHKVRFEGMEPLPSRSSRGSKVSPDVPPPSAGSDASHPSTSSSQLDGLSVSLGRLGTRCEPEPSRLQAVFEALLTQFDRLNQATEDVYQLEQQLHSLQGRRSSRAPAGSSRGPSPGLRPALPSRLARASRGVDLATGPSRTPLRAKNKVHPSST"},{"id":"SEQ_05970","a":"Q8NHJ6","g":"LILRB4","d":"Leukocyte immunoglobulin-like receptor subfamily B member 4","L":448,"m":[{"c":"[PS]KPTLxAxP[GS][SP]ψψ[ST][WS]G[NK]SVTψφCQ[GS]xxxφxxΩxLxKE(x){19,21}F[SP]ψ[PS][SP]ψT[ES]xx[AG]GxYRCΩ[YS](x){8,11}PSDPLELψψ[TS]G","u":"93-98","sp":"tandem","x":"structured_like","cf":"high","why":"Two tandem 93-98 aa structured domain repeats separated by a 2-residue linker (AY), anchored by invariant KPTL, pair of conserved cysteines (CQ and YRCΩ), GxSVT, and C-terminal PSDPLELψψ[TS]G motifs.","i":[[27,119,"PKPTLWAEPGSVISWGNSVTIWCQGTLEAREYRLDKEESPAPWDRQNPLEPKNKARFSIPSMTEDYAGRYRCYYRSPVGWSQPSDPLELVMTG"],[122,219,"SKPTLSALPSPLVTSGKSVTLLCQSRSPMDTFLLIKERAAHPLLHLRSEHGAQQHQAEFPMSPVTSVHGGTYRCFSSHGFSHYLLSHPSDPLELIVSG"]]},{"c":"[VS][TV]YAx[VL]","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed copies in the C-terminal P/S/E/Q-rich disordered tail encompassing all three tyrosines in this region, anchored by an invariant YA core flanked by [VS][TV] at Y-2/Y-1 and a large aliphatic [VL] at Y+3.","i":[[358,363,"VTYAKV"],[410,415,"VTYAQL"],[440,445,"SVYATL"]]}],"s":"MIPTFTALLCLGLSLGPRTHMQAGPLPKPTLWAEPGSVISWGNSVTIWCQGTLEAREYRLDKEESPAPWDRQNPLEPKNKARFSIPSMTEDYAGRYRCYYRSPVGWSQPSDPLELVMTGAYSKPTLSALPSPLVTSGKSVTLLCQSRSPMDTFLLIKERAAHPLLHLRSEHGAQQHQAEFPMSPVTSVHGGTYRCFSSHGFSHYLLSHPSDPLELIVSGSLEDPRPSPTRSVSTAAGPEDQPLMPTGSVPHSGLRRHWEVLIGVLVVSILLLSLLLFLLLQHWRQGKHRTLAQRQADFQRPPGAAEPEPKDGGLQRRSSPAADVQGENFCAAVKNTQPEDGVEMDTRQSPHDEDPQAVTYAKVKHSRPRREMASPPSPLSGEFLDTKDRQAEEDRQMDTEAAASEAPQDVTYAQLHSFTLRQKATEPPPSQEGASPAEPSVYATLAIH"},{"id":"SEQ_05984","a":"Q8N5F7","g":"NKAP","d":"NF-kappa-B-activating protein","L":415,"m":[{"c":"[TE]x[ERK]x[IL]ASFxxxx[YR]xx","u":15,"sp":"dispersed","x":"structured_like","cf":"high","why":"Three 15-aa helical-like repeats in the C-terminal structured region anchored by an invariant [IL]ASF core and N-terminal [TE]x[ERK] motif; the second and third copies lie nearly head-to-tail (1-aa gap) and additionally share C-terminal RK residues, while the first copy sits 23 aa upstream.","i":[[340,354,"TSEEIASFECSGYVM"],[378,392,"EKRALASFNQEERRK"],[394,408,"ENKILASFREMVYRK"]]}],"s":"MAPVSGSRSPDREASGSGGRRRSSSKSPKPSKSARSPRGRRSRSHSCSRSGDRNGLTHQLGGLSQGSRNQSYRSRSRSRSRERPSAPRGIPFASASSSVYYGSYSRPYGSDKPWPSLLDKEREESLRQKRLSERERIGELGAPEVWGLSPKNPEPDSDEHTPVEDEEPKKSTTSASTSEEEKKKKSSRSKERSKKRRKKKSSKRKHKKYSEDSDSDSDSETDSSDEDNKRRAKKAKKKEKKKKHRSKKYKKKRSKKSRKESSDSSSKESQEEFLENPWKDRTKAEEPSDLIGPEAPKTLTSQDDKPLNYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIASFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASFNQEERRKRENKILASFREMVYRKTKGKDDK"},{"id":"SEQ_05995","a":"Q9UQC2","g":"GAB2","d":"GRB2-associated-binding protein 2","L":676,"m":[{"c":"[ND]S[EQ][DES][NV]Y[VI]PMo","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 10-aa motifs in the C-terminal disordered region anchored by invariant S (pos 2), Y (pos 6), P (pos 8), and M (pos 9), a strict [VI] aliphatic choice at pos 7, and conserved polar/acidic flanking positions.","i":[[447,456,"NSEDNYVPMN"],[471,480,"NSQSVYIPMS"],[579,588,"DSEENYVPMQ"]]}],"s":"MSGGGDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQICGFNQAEESTDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNHMQPTLSTSAPQEYLYLHQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCVNGISGQVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHGHTKGSLTGSETDNEDVYTFKTPSNTLCREFGDLLVDNMDVPATPLSAYQIPRTFTLDKNHNAMTVATPGDSAIAPPPRPPKPSQAETPRWGSPQQRPPISENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNPGSSTLLAMERAGDNSQSVYIPMSPGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELPFKSPITKSWSRANHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVPSGTNSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPSKGAKL"},{"id":"SEQ_06002","a":"Q01955","g":"COL4A3","d":"Collagen alpha-3(IV) chain","L":1670,"m":[{"c":"HSQTTxIP[SP]CPxGxψxLΩxGFSFψφφo[GS](x){5,6}GQxLxxxGSCL[QE]xFxxxPFLxCxxxxxCNΩ(x){4,5}YSΩWL[SA]oxxxxxMxxxPI(x){4,8}LExφISRCoVC","u":"101-105","sp":"periodic","x":"structured_like","cf":"high","why":"Strongly conserved two-copy C-terminal globular domain duplication (~101-105 aa, separated by a 9-aa linker) following the long collagenous G-x-y tract, anchored by six invariant cysteines and conserved blocks including HSQTT, CP, GFSFψφφ, GQxL, GSCL, PFLxC, YSΩWL, PI, and LExφISRCoVC.","i":[[1451,1551,"HSQTTAIPSCPEGTVPLYSGFSFLFVQGNQRAHGQDLGTLGSCLQRFTTMPFLFCNVNDVCNFASRNDYSYWLSTPALMPMNMAPITGRALEPYISRCTVC"],[1561,1665,"HSQTTDIPPCPHGWISLWKGFSFIMFTSAGSEGTGQALASPGSCLEEFRASPFLECHGRGTCNYYSNSYSFWLASLNPERMFRKPIPSTVKAGELEKIISRCQVC"]]}],"s":"MSARTAPRPQVLLLPLLLVLLAAAPAASKGCVCKDKGQCFCDGAKGEKGEKGFPGPPGSPGQKGFTGPEGLPGPQGPKGFPGLPGLTGSKGVRGISGLPGFSGSPGLPGTPGNTGPYGLVGVPGCSGSKGEQGFPGLPGTLGYPGIPGAAGLKGQKGAPAKEEDIELDAKGDPGLPGAPGPQGLPGPPGFPGPVGPPGPPGFFGFPGAMGPRGPKGHMGERVIGHKGERGVKGLTGPPGPPGTVIVTLTGPDNRTDLKGEKGDKGAMGEPGPPGPSGLPGESYGSEKGAPGDPGLQGKPGKDGVPGFPGSEGVKGNRGFPGLMGEDGIKGQKGDIGPPGFRGPTEYYDTYQEKGDEGTPGPPGPRGARGPQGPSGPPGVPGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGPPGPPGDIVFRKGPPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPPGLPGLPGLHGVKGIPGRQGAAGLKGSPGSPGNTGLPGFPGFPGAQGDPGLKGEKGETLQPEGQVGVPGDPGLRGQPGRKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGPPGDPGSPGSPGPAGPAGPPGYGPQGEPGLQGTQGVPGAPGPPGEAGPRGELSVSTPVPGPPGPPGPPGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIPGIGFPGPPGPKGDQGFPGTKGSLGCPGKMGEPGLPGKPGLPGAKGEPAVAMPGGPGTPGFPGERGNSGEHGEIGLPGLPGLPGTPGNEGLDGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTGPKGDPGIPGLDRSGFPGETGSPGIPGHQGEMGPLGQRGYPGNPGILGPPGEDGVIGMMGFPGAIGPPGPPGNPGTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGNPGPSEISHVIGDKGEPGLKGFAGNPGEKGNRGVPGMPGLKGLKGLPGPAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGRAGRPGLPGIHGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDMGKKGEMGQPGPPGHLGPAGPEGAPGSPGSPGLPGKPGPHGDLGFKGIKGLLGPPGIRGPPGLPGFPGSPGPMGIRGDQGRDGIPGPAGEKGETGLLRAPPGPRGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAGPRGPTGIEGFPGPPGLPGAIIPGQTGNRGPPGSRGSPGAPGPPGPPGSHVIGIKGDKGSMGHPGPKGPPGTAGDMGPPGRLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPKGPPGVRGDPGTLKIISLPGSPGPPGTPGEPGMQGEPGPPGPPGNLGPCGPRGKPGKDGKPGTPGPAGEKGNKGSKGEPGPAGSDGLPGLKGKRGDSGSPATWTTRGFVFTRHSQTTAIPSCPEGTVPLYSGFSFLFVQGNQRAHGQDLGTLGSCLQRFTTMPFLFCNVNDVCNFASRNDYSYWLSTPALMPMNMAPITGRALEPYISRCTVCEGPAIAIAVHSQTTDIPPCPHGWISLWKGFSFIMFTSAGSEGTGQALASPGSCLEEFRASPFLECHGRGTCNYYSNSYSFWLASLNPERMFRKPIPSTVKAGELEKIISRCQVCMKKRH"},{"id":"SEQ_06030","a":"Q2KHM9","g":"KIAA0753","d":"Protein moonraker","L":967,"m":[{"c":"RLxWLDAETS+RxKELxELKAxEψxxψQ","u":28,"sp":"tandem","x":"structured_like","cf":"high","why":"Strongly conserved 28-aa tandem duplication (2-aa linker) sharing 19 identical anchor positions including an invariant WLDAETS motif and conserved charged/aliphatic helical positions.","i":[[610,637,"RLAWLDAETSKRLKELEELKAKEIDSMQ"],[640,667,"RLDWLDAETSRRTKELNELKAEEMYRLQ"]]}],"s":"MGPGQPASTCVHLAPRTQLDGRSDPKVLQTQNQLQFNRNVPTHSSNLAIRYSCPHAIRIEKLKHSYNESYHCKDADCRVGPDLGSSVSFSVISQERLSYAVHLARRDVKRRQFEKHIKEHHLRSQPQSSQKCGHTKYKIPDHRVERKESKSQAACQCSHQPSKVEISSSGAKVYLYSSHPGQSDLTVPNSPPTHDPGLQPHPRIGDHKNISEQKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEALESLLEKKLSPKKVKKCFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDTELPETQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQQTTVSSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNELKAEEMYRLQQLSVSATHLADKVEEAVLDRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPRLWMQEENNDQKISAISEKPLSPHPIRITKTVDRKDPAVNIMLERPCNGNSLDESVGTEEGSEKREAPLLSLAEDSQQKEGRAPLFVPPGMQHSIGDYCSRFEQYLRIISHEAVGSFNPWLIAESFSEELVDEALGAVAAELQDMCEDYAEAVFTSEFLEAAT"},{"id":"SEQ_06037","a":"O60503","g":"ADCY9","d":"Adenylate cyclase type 9","L":1353,"m":[{"c":"[IV][LI]FA[DS]IV[GN]F[TS](x){13,15}[LV]LN[DE]L[FI]GxFD[RE]L(x){7,10}KIxT[LI]GxxY[YM]x[VA][AS]G(x){12,15}[IL][EQ]ψx[LF]xxφK[AE]ψxx[FV](x){9,14}ψRVGφxxGxxψxxGψψGxx+φxΩDψWxxxVNψAoxM-oxGVxx+ψxψSEx[TS]x+φL(x){21,27}KTYL[IY]","u":"177-184","sp":"dispersed","x":"structured_like","cf":"high","why":"Two-copy internal duplication of a ~180 aa structured region separated by a ~487 aa transmembrane-containing segment, anchored by multiple conserved blocks including [IV][LI]FA[DS]IV[GN]F[TS], [LV]LN[DE]L[FI]GxFD[RE]L, an ungapped 54-residue core (ψRVGφ...ΩDψWxxxVNψAoxM...GV...SEx[TS]x+φL), and a C-terminal KTYL[IY] motif.","i":[[395,571,"ILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQSVVADQLKGLKTYLI"],[1059,1242,"VIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLY"]]}],"s":"MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEERGRFGKAIEKDDCDETGIEEANELTKLNVSKSV"},{"id":"SEQ_06038","a":"P07359","g":"GP1BA","d":"Platelet glycoprotein Ib alpha chain","L":652,"m":[{"c":"xxLx[LV]xx[NC]xLxxφ(x){8,10}L","u":"22-24","sp":"tandem","x":"structured_like","cf":"high","why":"Seven contiguous 22-24 aa leucine-rich repeats in the N-terminal structured ectodomain anchored by invariant L at positions 3, 10, and the C-terminus, conserved [LV] at position 5, [NC] at position 8, and hydrophobic φ at position 13.","i":[[50,73,"TILHLSENLLYTFSLATLMPYTRL"],[74,95,"TQLNLDRCELTKLQVDGTLPVL"],[96,118,"GTLDLSHNQLQSLPLLGQTLPAL"],[119,142,"TVLDVSFNRLTSLPLGALRGLGEL"],[143,166,"QELYLKGNELKTLPPGLLTPTPKL"],[167,190,"EKLSLANNNLTELPAGLLNGLENL"],[191,213,"DTLLLQENSLYTIPKGFFGSHLL"]]},{"c":"SPTT[SP]EP[TV][SP][EI]P[AT][PI]","u":13,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five 13-aa repeats in the Pro/Thr/Ser/Glu-rich disordered stalk anchored by invariant SPTT (positions 1-4), EP (positions 6-7), and P (position 11); copies 2-5 form a contiguous head-to-tail tandem array (with copies 2-4 identical) separated by a 9-aa partial-repeat linker from copy 1.","i":[[385,397,"SPTTSEPVPEPAP"],[407,419,"SPTTPEPTSEPAP"],[420,432,"SPTTPEPTSEPAP"],[433,445,"SPTTPEPTSEPAP"],[446,458,"SPTTPEPTPIPTI"]]}],"s":"MPLLLLLLLLPSPLHPHPICEVSKVASHLEVNCDKRNLTALPPDLPKDTTILHLSENLLYTFSLATLMPYTRLTQLNLDRCELTKLQVDGTLPVLGTLDLSHNQLQSLPLLGQTLPALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNNLTELPAGLLNGLENLDTLLLQENSLYTIPKGFFGSHLLPFAFLHGNPWLCNCEILYFRRWLQDNAENVYVWKQGVDVKAMTSNVASVQCDNSDKFPVYKYPGKGCPTLGDEGDTDLYDYYPEEDTEGDKVRATRTVVKFPTKAHTTPWGLFYSWSTASLDSQMPSSLHPTQESTKEQTTFPPRWTPNFTLHMESITFSKTPKSTTEPTPSPTTSEPVPEPAPNMTTLEPTPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTPIPTIATSPTILVSATSLITPKSTFLTTTKPVSLLESTKKTIPELDQPPKLRGVLQGHLESSRNDPFLHPDFCCLLPLGFYVLGLFWLLFASVVLILLLSWVGHVKPQALDSGQGAALTTATQTTHLELQRGRQVTVPRAWLLFLRGSLPTFRSSLFLWVRPNGRVGPLVAGRRPSALSQGRGQDLLSTVSIRYSGHSL"},{"id":"SEQ_06044","a":"Q8IV32","g":"CCDC71","d":"Coiled-coil domain-containing protein 71","L":467,"m":[{"c":"[TR]A[QK]AKVART[LQ][AP]","u":11,"sp":"dispersed","x":"mixed","cf":"high","why":"Three dispersed 11-aa repeats flanking the central tandem array, anchored by seven invariant positions (xAxAKVARTxx) and four tightly constrained 2-choice positions.","i":[[280,290,"TAQAKVARTLA"],[294,304,"RAQAKVARTQA"],[350,360,"RAKAKVARTQP"]]},{"c":"[AQW][AV]KA+AK[AV][KM]A[AV]","u":11,"sp":"tandem","x":"mixed","cf":"high","why":"Four contiguous head-to-tail 11-aa repeats positioned cleanly between copies 2 and 3 of the AKVART motif, locked into a strict 11-residue register by N-terminal [AQW][AV] (notably QV/QV/WA) and C-terminal A[AV] anchors around a conserved KA+AK core.","i":[[306,316,"AAKARAKAKAA"],[317,327,"QVKAKAKAKAA"],[328,338,"QVKAKAKVMAA"],[339,349,"WAKAKAKAKAV"]]}],"s":"MSVVVQHVEEKAVHSWSRISTAGKKALEEALLVFNPMSQDLSATEAQLVAFLQGLRDDGFQPTILRSGDVYGYSSCTANPPSQTKLQARAPNPTATSPPASAPRTAMRLPAGRATLLPMPLSGRLAKASTPALAKHATTNLLLSSLKQSSASHARGAAVGFPTHLYPGVYPAMRLSVVLEALVPLKTPMPCLGAKHKAQSLQLSLADSPLKLRKSSGKGPGNPRPKAPRKTTSKGPKCLTRKGPGAGPRRGSGHQSKTNRATGSPSVRRMKGGSALGTKTAQAKVARTLAKAARAQAKVARTQAKAAKARAKAKAAQVKAKAKAKAAQVKAKAKVMAAWAKAKAKAKAVRAKAKVARTQPRGRGRPKGSAKARTTRKGQKNRPETVGQKRKRAEEAKDLPPKKRTRLGPRSPKAWLGPGTAKLLKFRAIKVDRRSSDDEVRQRAQRILRVNLSPVIRLQPLLPYSAV"},{"id":"SEQ_06057","a":"Q5XUX0","g":"FBXO31","d":"F-box only protein 31","L":539,"m":[{"c":"DxxφxφxxψYLPPxxP(x){0,2}DD(x){1,3}φKP(x){0,1}LF+(x){7,10}ψE[CI]ψφ(x){11,12}I[VT]","u":"52-57","sp":"dispersed","x":"structured_like","cf":"medium","why":"Two dispersed ~52-57 aa internal domain duplications separated by a 60 aa linker share a strongly conserved N-terminal signature (DxxφxφxxψYLPPxxP, DD, φKP, and LF+) followed by a conserved hydrophobic/acidic core (ψE[CI]ψφ) and C-terminal I[VT].","i":[[165,221,"DGLFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVECMYGHKGPHHGHIQIV"],[281,332,"DNCLTYRRIYLPPSRPDDLIKPGLFKGTYGSHGLEIVMLSFHGRRARGTKIT"]]}],"s":"MAVCARLCGVGPSRGCRRRQQRRGPAETAAADSEPDTDPEEERIEASAGVGGGLCAGPSPPPPRCSLLELPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIWRRRCREEYGVCENLRKLEITGVSCRDVYAKLLHRYRHILGLWQPDIGPYGGLLNVVVDGLFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVECMYGHKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQEEFRTWLREEWGRTLEDIFHEHMQELILMKFIYTSQYDNCLTYRRIYLPPSRPDDLIKPGLFKGTYGSHGLEIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDLENQRNFNELSRIVLEVRERVRQEQQEGGHEAGEGRGRQGPRESQPSPAQPRAEAPSKGPDGTPGEDGGEPGDAVAAAEQPAQCGQGQPFVLPVGVSSRNEDYPRTCRMCFYGTGLIAGHGFTSPERTPGVFILFDEDRFGFVWLELKSFSLYSRVQATFRNADAPSPQAFDEMLKNIQSLTS"},{"id":"SEQ_06058","a":"Q13625","g":"TP53BP2","d":"Apoptosis-stimulating of p53 protein 2","L":1128,"m":[{"c":"[ND]x-GφT[AP]LHxAφ[CS][AC]xxxxψxKFLVxxGφxVxAφ","u":33,"sp":"tandem","x":"structured_like","cf":"high","why":"Two head-to-tail 33 aa structured repeats in the C-terminal region share 12 identical anchors (G, T, L, H, A, KFLV, G, V, A) and 9 physicochemically conserved positions across the full repeat unit.","i":[[956,988,"NDEGITALHNAVCAGHTEIVKFLVQFGVNVNAA"],[989,1021,"DSDGWTPLHCAASCNNVQVCKFLVESGAAVFAM"]]}],"s":"MMPMFLTVYLSNNEQHFTEVPVTPETICRDVVDLCKEPGESDCHLAEVWCGSERPVADNERMFDVLQRFGSQRNEVRFFLRHERPPGRDIVSGPRSQDPSLKRNGVKVPGEYRRKENGVNSPRMDLTLAELQEMASRQQQQIEAQQQLLATKEQRLKFLKQQDQRQQQQVAEQEKLKRLKEIAENQEAKLKKVRALKGHVEQKRLSNGKLVEEIEQMNNLFQQKQRELVLAVSKVEELTRQLEMLKNGRIDSHHDNQSAVAELDRLYKELQLRNKLNQEQNAKLQQQRECLNKRNSEVAVMDKRVNELRDRLWKKKAALQQKENLPVSSDGNLPQQAASAPSRVAAVGPYIQSSTMPRMPSRPELLVKPALPDGSLVIQASEGPMKIQTLPNMRSGAASQTKGSKIHPVGPDWSPSNADLFPSQGSASVPQSTGNALDQVDDGEVPLREKEKKVRPFSMFDAVDQSNAPPSFGTLRKNQSSEDILRDAQVANKNVAKVPPPVPTKPKQINLPYFGQTNQPPSDIKPDGSSQQLSTVVPSMGTKPKPAGQQPRVLLSPSIPSVGQDQTLSPGSKQESPPAAAVRPFTPQPSKDTLLPPFRKPQTVAASSIYSMYTQQQAPGKNFQQAVQSALTKTHTRGPHFSSVYGKPVIAAAQNQQQHPENIYSNSQGKPGSPEPETEPVSSVQENHENERIPRPLSPTKLLPFLSNPYRNQSDADLEALRKKLSNAPRPLKKRSSITEPEGPNGPNIQKLLYQRTTIAAMETISVPSYPSKSASVTASSESPVEIQNPYLHVEPEKEVVSLVPESLSPEDVGNASTENSDMPAPSPGLDYEPEGVPDNSPNLQNNPEEPNPEAPHVLDVYLEEYPPYPPPPYPSGEPEGPGEDSVSMRPPEITGQVSLPPGKRTNLRKTGSERIAHGMRVKFNPLALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMTYSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGVIYALWDYEPQNDDELPMKEGDCMTIIHREDEDEIEWWWARLNDKEGYVPRNLLGLYPRIKPRQRSLA"},{"id":"SEQ_06074","a":"Q96MS0","g":"ROBO3","d":"Roundabout homolog 3","L":1386,"m":[{"c":"[DN]xxφxx[GD]x[PS][AV]x[LF]xC(x){3,4}GxPxPxψxWxK(x){1,2}G(x){23,35}DxGxYxC[VQ]AxxxxG(x){9,12}[VKM]","u":"80-92","sp":"periodic","x":"structured_like","cf":"high","why":"Five periodic 80-92 aa structured repeats in the N-terminal half separated by 9-16 aa linkers, anchored by two invariant cysteines ([DN]xxφxx[GD]x[PS][AV]x[LF]xC and DxGxYxC[VQ]AxxxxG) and a conserved GxPxPxψxWxK(x){1,2}G motif.","i":[[72,163,"DLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAV"],[174,254,"NVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMV"],[266,345,"NQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHV"],[355,442,"DQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIK"],[459,538,"NQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKM"]]},{"c":"Q(x){9,13}ψx[LV][TS]W(x){11,14}Ωxψ(x){10,17}W(x){7,16}GLxP[NG][TL]x[YI]xx[LK]VxAxxxxG[LV][SG]x[PE]S(x){5,6}","u":"86-90","sp":"dispersed","x":"structured_like","cf":"high","why":"Three non-overlapping 86-90 aa structured repeats immediately C-terminal to the first repeat array (separated by 28 and 11 aa linkers), defined by conserved ψx[LV][TS]W, Ωxψ, internal W, and C-terminal GLxP[NG][TL]x[YI]xx[LK]VxAxxxxG[LV][SG]x[PE]S anchors.","i":[[561,647,"QPVVTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPV"],[676,761,"QEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTR"],[773,862,"QGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLV"]]}],"s":"MLRYLLKTLLQMNLFADSLAGDISNSSELLLGFNSSLAALNHTLLPPGDPSLNGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPDLEPGLEVGAGLAVRLARVLREPAFLAGSGAACGALLLGLCAALYWRRKQRKELSHYTASFAYTPAVSFPHSEGLSGASSRPPMGLGPAPYSWLADSWPHPSRSPSAQEPRGSCCPSNPDPDDRYYNEAGISLYLAQTARGTAAPGEGPVYSTIDPAGEELQTFHGGFPQHPSGDLGPWSQYAPPEWSQGDSGAKGGKVKLLGKPVQMPSLNWPEALPPPPPSCELSCLEGPEEELEGSSEPEEWCPPMPERSHLTEPSSSGGCLVTPSRRETPSPTPSYGQQSTATLTPSPPDPPQPPTDMPHLHQMPRRVPLGPSSPLSVSQPMLGIREARPAGLGAGPAASPHLSPSPAPSTASSAPGRTWQGNGEMTPPLQGPRARFRKKPKALPYRRENSPGDLPPPPLPPPEEEASWALELRAAGSMSSLERERSGERKAVQAVPLAAQRVLHPDEEAWLPYSRPSFLSRGQGTSTCSTAGSNSSRGSSSSRGSRGPGRSRSRSQSRSQSQRPGQKRREEPR"},{"id":"SEQ_06085","a":"P17029","g":"ZKSCAN1","d":"Zinc finger protein with KRAB and SCAN domains 1","L":563,"m":[{"c":"[YH][ERK]Cx[EK]CGK[AC]F[STN]x[SN][ST]x[LT]xxHx[RI]IH[TSA][GR]E+[PA]","u":28,"sp":"tandem","x":"structured_like","cf":"high","why":"Six contiguous head-to-tail 28-aa repeats (residues 377-544) defined by invariant C..CGK.F and H..IH cysteinyl/histidinyl anchors, polar [STN]/[SN]/[ST] positions, and a conserved E+[PA] C-terminal linker.","i":[[377,404,"HRCDECGKCFTRSSSLIRHKIIHTGEKP"],[405,432,"YECSECGKAFSLNSNLVLHQRIHTGEKP"],[433,460,"HECNECGKAFSHSSNLILHQRIHSGEKP"],[461,488,"YECNECGKAFSQSSDLTKHQRIHTGEKP"],[489,516,"YECSECGKAFNRNSYLILHRRIHTREKP"],[517,544,"YKCTKCGKAFTRSSTLTLHHRIHARERA"]]}],"s":"MMTAESREATGLSPQAAQEKDGIVIVKVEEEDEEDHMWGQDSTLQDTPPPDPEIFRQRFRRFCYQNTFGPREALSRLKELCHQWLRPEINTKEQILELLVLEQFLSILPKELQVWLQEYRPDSGEEAVTLLEDLELDLSGQQVPGQVHGPEMLARGMVPLDPVQESSSFDLHHEATQSHFKHSSRKPRLLQSRALPAAHIPAPPHEGSPRDQAMASALFTADSQAMVKIEDMAVSLILEEWGCQNLARRNLSRDNRQENYGSAFPQGGENRNENEESTSKAETSEDSASRGETTGRSQKEFGEKRDQEGKTGERQQKNPEEKTRKEKRDSGPAIGKDKKTITGERGPREKGKGLGRSFSLSSNFTTPEEVPTGTKSHRCDECGKCFTRSSSLIRHKIIHTGEKPYECSECGKAFSLNSNLVLHQRIHTGEKPHECNECGKAFSHSSNLILHQRIHSGEKPYECNECGKAFSQSSDLTKHQRIHTGEKPYECSECGKAFNRNSYLILHRRIHTREKPYKCTKCGKAFTRSSTLTLHHRIHARERASEYSPASLDAFGAFLKSCV"},{"id":"SEQ_06088","a":"Q9P260","g":"RELCH","d":"RAB11-binding protein RELCH","L":1216,"m":[{"c":"[VER]xxx[LV][LG]xx[LC]xxxψxxxxx[EDA]x[RV]x[EML]φφxx[CSI][LVG][AGC]x[AI]xxx[PGI]xxx","u":39,"sp":"tandem","x":"structured_like","cf":"medium","why":"Four head-to-tail 39-aa bi-helical repeats (residues 519-674) with conserved aliphatic/hydrophobic core dyads ([LV][LG]..[LC]...ψ in the first helix and φφ..[CSI][LVG][AGC].[AI] in the second helix) separated by an acidic/basic turn, forming the best-conserved tandem core of a broader C-terminal α-solenoid array.","i":[[519,557,"VMLMLGRCLPHIVPNVLLAKREELIPLILCTACLHPEPK"],[558,596,"ERDQLLHILFNLIKRPDDEQRQMILTGCVAFARHVGPTR"],[597,635,"VEAELLPQCWEQINHKYPERRLLVAESCGALAPYLPKEI"],[636,674,"RSSLVLSMLQQMLMEDKADLVREAVIKSLGIIMGYIDDP"]]}],"s":"MAAMAPGGSGSGGGVNPFLSDSDEDDDEVAATEERRAVLRLGAGSGLDPGSAGSLSPQDPVALGSSARPGLPGEASAAAVALGGTGETPARLSIDAIAAQLLRDQYLLTALELHTELLESGRELPRLRDYFSNPGNFERQSGTPPGMGAPGVPGAAGVGGAGGREPSTASGGGQLNRAGSISTLDSLDFARYSDDGNRETDEKVAVLEFELRKAKETIQALRANLTKAAEHEVPLQERKNYKSSPEIQEPIKPLEKRALNFLVNEFLLKNNYKLTSITFSDENDDQDFELWDDVGLNIPKPPDLLQLYRDFGNHQVTGKDLVDVASGVEEDELEALTPIISNLPPTLETPQPAENSMLVQKLEDKISLLNSEKWSLMEQIRRLKSEMDFLKNEHFAIPAVCDSVQPPLDQLPHKDSEDSGQHPDVNSSDKGKNTDIHLSISDEADSTIPKENSPNSFPRREREGMPPSSLSSKKTVHFDKPNRKLSPAFHQALLSFCRMSADSRLGYEVSRIADSEKSVMLMLGRCLPHIVPNVLLAKREELIPLILCTACLHPEPKERDQLLHILFNLIKRPDDEQRQMILTGCVAFARHVGPTRVEAELLPQCWEQINHKYPERRLLVAESCGALAPYLPKEIRSSLVLSMLQQMLMEDKADLVREAVIKSLGIIMGYIDDPDKYHQGFELLLSALGDPSERVVSATHQVFLPAYAAWTTELGNLQSHLILTLLNKIEKLLREGEHGLDEHKLHMYLSALQSLIPSLFALVLQNAPFSSKAKLHGEVPQIEVTRFPRPMSPLQDVSTIIGSREQLAVLLQLYDYQLEQEGTTGWESLLWVVNQLLPQLIEIVGKINVTSTACVHEFSRFFWRLCRTFGKIFTNTKVKPQFQEILRLSEENIDSSAGNGVLTKATVPIYATGVLTCYIQEEDRKLLVGFLEDVMTLLSLSHAPLDSLKASFVELGANPAYHELLLTVLWYGVVHTSALVRCTAARMFELTLRGMSEALVDKRVAPALVTLSSDPEFSVRIATIPAFGTIMETVIQRELLERVKMQLASFLEDPQYQDQHSLHTEIIKTFGRVGPNAEPRFRDEFVIPHLHKLALVNNLQIVDSKRLDIATHLFEAYSALSCCFISEDLMVNHFLPGLRCLRTDMEHLSPEHEVILSSMIKECEQKVENKTVQEPQGSMSIAASLVSEDTKTKFLNKMGQLTTSGAMLANVFQRKK"},{"id":"SEQ_06106","a":"Q496Y0","g":"LONRF3","d":"LON peptidase N-terminal domain and RING finger protein 3","L":759,"m":[{"c":"CxxCxxφφx-PV[ST]xxCGHTFC[KL][KL]CLERxxxxxx+CxLCxxxLS","u":43,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two highly conserved 43-aa cysteine/histidine-anchored internal repeats sharing 18 identical positions (including CxxC, PV, CGHTFC, CLER, CxLC, and LS) plus conserved hydrophobic and charged positions, separated by a 267-aa spacer.","i":[[158,200,"CRKCHGFLSDPVSLSCGHTFCKLCLERGRAADRRCALCGVKLS"],[467,509,"CALCMRLFYEPVTTPCGHTFCLKCLERCLDHNAKCPLCKDGLS"]]},{"c":"xxxxx[GSA][NQ]xφφ[RT]xxxxExALxxφxx[AC][VC][KS]Lx[PG]xxxx","u":34,"sp":"tandem","x":"structured_like","cf":"medium","why":"Three head-to-tail 34-aa structured repeats anchored by an invariant ExAL motif, conserved hydrophobic core positions, an N-terminal [GSA][NQ]xφφ[RT] turn/helix segment, and a C-terminal Lx[PG] turn motif.","i":[[245,278,"QLRHEGNRLYRERQVEAALLKYNEAVKLAPNDHL"],[279,312,"LYSNRSQIYFTLESHENALHDAEIACKLRPMGFK"],[313,346,"AHFRKAQALATLGKVEEALREFLYCVSLDGKNKR"]]}],"s":"MESVRIEQMLSLPAEVSSDNLESAERGASAAQVDMGPHPKVAAEGPAPLPTREPEQEQSPGTSTPESKVLLTQADALASRGRIREALEVYRQLSERQQLVAEQLEQLVRCLAEKVPQGEALAPAPPDEGSTASGTVAAEETGAAAAAAATEVWDGFKCRKCHGFLSDPVSLSCGHTFCKLCLERGRAADRRCALCGVKLSALMVATGRARGARRAGQQPPPPLRVNVVLSGLLGKLFPGPARASQLRHEGNRLYRERQVEAALLKYNEAVKLAPNDHLLYSNRSQIYFTLESHENALHDAEIACKLRPMGFKAHFRKAQALATLGKVEEALREFLYCVSLDGKNKRARCEAQRDNLELPHCSSQEEAAARGDGSSLMDPAKVKGDGQQHHMKDQEEEEEKWDATSPKAASSKTGKCQEKKRKHCQIESQEETGMPNKASKQDPPTDQGDKPALSLPLASFDASDLECALCMRLFYEPVTTPCGHTFCLKCLERCLDHNAKCPLCKDGLSQCLASRKYSKNVIMEELIAKFLPEELKERRKLYEEEMEELSNLNKNVPIFVCTMAYPTVPCPLHIFEPCYRLMIRRCIETGTRQFGMCLGDPVKGFAEYGCILEIRNVQFFADGRSVVDSIGKRRFRVLHQSQRDGYNTADIEYIEDQKVQGEDCAELMGLHNCVYQQASLWFHSLKLSLKNRILNHFGPMPEKDADPQMNPNGPAWCWWMLAVLPLESRAQLPFLAMRSLKDRLNGIRRVLAFISRNQN"},{"id":"SEQ_06108","a":"Q5H9F3","g":"BCORL1","d":"BCL-6 corepressor-like protein 1","L":1785,"m":[{"c":"xx[ADS]Gx[TR][LAP]ψ[QHK]xAxxxxxxxxψxxxL(x){4,5}xxxxx","u":"33-34","sp":"tandem","x":"structured_like","cf":"high","why":"Four tandem 33-34 aa structured repeats in the C-terminal region anchored by invariant G (pos 4), A (pos 11), and L (pos 24) residues, conserved large aliphatic positions (pos 8 and 20), and a 1-aa loop length variation in the first copy.","i":[[1493,1526,"KNAGETLLQRAARLGYKDVVLYCLQKDSEDVNHR"],[1527,1559,"DNAGYTALHEACSRGWTDILNILLEHGANVNCS"],[1560,1592,"AQDGTRPVHDAVVNDNLETIWLLLSYGADPTLA"],[1593,1625,"TYSGQTAMKLASSDTMKRFLSDHLSDLQGRAEG"]]}],"s":"MISTAPLYSGVHNWTSSDRIRMCGINEERRAPLSDEESTTGDCQHFGSQEFCVSSSFSKVELTAVGSGSNARGADPDGSATEKLGHKSEDKPDDPQPKMDYAGNVAEAEGLLVPLSSPGDGLKLPASDSAEASNSRADCSWTPLNTQMSKQVDCSPAGVKALDSRQGVGEKNTFILATLGTGVPVEGTLPLVTTNFSPLPAPICPPAPGSASVPHSVPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALAPAPPSVPTLISDSNPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPVPTPVLAPMPASTPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAIPTSAPIPASFSLSRVCFPAAQAPAMQKVPLSFQPGTVLTPSQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPSYLQDRCLPGVLASPELRSYPYAFSVARPLTSDSKLVSLEVNRLPCTSPSGSTTTQPAPDGVPGPLADTSLVTASAKVLPTPQPLLPAPSGSSAPPHPAKMPSGTEQQTEGTSVTFSPLKSPPQLEREMASPPECSEMPLDLSSKSNRQKLPLPNQRKTPPMPVLTPVHTSSKALLSTVLSRSQRTTQAAGGNVTSCLGSTSSPFVIFPEIVRNGDPSTWVKNSTALISTIPGTYVGVANPVPASLLLNKDPNLGLNRDPRHLPKQEPISIIDQGEPKGTGATCGKKGSQAGAEGQPSTVKRYTPARIAPGLPGCQTKELSLWKPTGPANIYPRCSVNGKPTSTQVLPVGWSPYHQASLLSIGISSAGQLTPSQGAPIRPTSVVSEFSGVPSLSSSEAVHGLPEGQPRPGGSFVPEQDPVTKNKTCRIAAKPYEEQVNPVLLTLSPQTGTLALSVQPSGGDIRMNQGPEESESHLCSDSTPKMEGPQGACGLKLAGDTKPKNQVLATYMSHELVLATPQNLPKMPELPLLPHDSHPKELILDVVPSSRRGSSTERPQLGSQVDLGRVKMEKVDGDVVFNLATCFRADGLPVAPQRGQAEVRAKAGQARVKQESVGVFACKNKWQPDDVTESLPPKKMKCGKEKDSEEQQLQPQAKAVVRSSHRPKCRKLPSDPQESTKKSPRGASDSGKEHNGVRGKHKHRKPTKPESQSPGKRADSHEEGSLEKKAKSSFRDFIPVVLSTRTRSQSGSICSSFAGMADSDMGSQEVFPTEEEEEVTPTPAKRRKVRKTQRDTQYRSHHAQDKSLLSQGRRHLWRAREMPWRTEAARQMWDTNEEEEEEEEEGLLKRKKRRRQKSRKYQTGEYLTEQEDEQRRKGRADLKARKQKTSSSQSLEHRLRNRNLLLPNKVQGISDSPNGFLPNNLEEPACLENSEKPSGKRKCKTKHMATVSEEAKGKGRWSQQKTRSPKSPTPVKPTEPCTPSKSRSASSEEASESPTARQIPPEARRLIVNKNAGETLLQRAARLGYKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDTMKRFLSDHLSDLQGRAEGDPGVSWDFYSSSVLEEKDGFACDLLHNPPGSSDQEGDDPMEEDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAERPGGLDDRSPPGSSETVELVRYEPDLLRLLGSEVEFQSCNS"},{"id":"SEQ_06114","a":"Q86UN2","g":"RTN4RL1","d":"Reticulon-4 receptor-like 1","L":441,"m":[{"c":"[LV]x[LI]xx[NC](x){1,2}[LI]xxψxxxx[FL](x){3,5}[LM]xx","u":"22-25","sp":"tandem","x":"structured_like","cf":"high","why":"Eight head-to-tail tandem 22-25 aa (predominantly 24 aa) leucine-rich repeats spanning residues 59-249, anchored by a periodic hydrophobic spine ([LV]x[LI], [LI]xxψ, [FL], and C-terminal [LM]) and a conserved [NC] ladder position.","i":[[59,80,"VFLQNNRIGLLQPGHFSPAMVT"],[81,104,"LWIYSNNITYIHPSTFEGFVHLEE"],[105,129,"LDLGDNRQLRTLAPETFQGLVKLHA"],[130,153,"LYLYKCGLSALPAGVFGGLHSLQY"],[154,177,"LYLQDNHIEYLQDDIFVDLVNLSH"],[178,201,"LFLHGNKLWSLGPGTFRGLVNLDR"],[202,225,"LLLHENQLQWVHHKAFHDLRRLTT"],[226,249,"LFLFNNSLSELQGECLAPLGALEF"]]}],"s":"MLRKGCCVELLLLLVAAELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTGPASPHQIKSHTLTTTDRAARKEHHSPHGPTRSKGHPHGPRPGHRKPGKNCTNPRNRNQISKAGAGKQAPELPDYAPDYQHKFSFDIMPTARPKRKGKCARRTPIRAPSGVQQASSASSLGASLLAWTLGLAVTLR"},{"id":"SEQ_06138","a":"Q9H0K1","g":"SIK2","d":"Serine/threonine-protein kinase SIK2","L":926,"m":[{"c":"[SP]PR(x){0,1}SLEoQφx[QE]HRLQ[KQ]xxLφx[KQ]xQoo[CL]QφY[CF]","u":"31-32","sp":"tandem","x":"mixed","cf":"high","why":"Strongly conserved 2-copy tandem duplication (31-32 aa, separated by a 2-aa KE linker) sharing 14 identical positions ([SP]PR N-cap, SLE, HRLQ, L, Q, Q, and C-terminal Y) plus six physicochemically conserved hydrophobic and polar positions.","i":[[670,701,"SPRQSLETQYLQHRLQKPSLLSKAQNTCQLYC"],[704,734,"PPRSLEQQLQEHRLQQKRLFLQKQSQLQAYF"]]}],"s":"MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN"},{"id":"SEQ_06143","a":"Q86V48","g":"LUZP1","d":"Leucine zipper protein 1","L":1076,"m":[{"c":"[SA]PxEALRxR","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 9-aa copies in the C-terminal disordered region share six strictly invariant anchor positions (PxEALRxR) and a conserved [SA] N-terminal position.","i":[[639,647,"SPHEALRCR"],[745,753,"SPREALRSR"],[809,817,"APGEALRER"]]}],"s":"MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSREQPSVLSRYPPAAQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHGSVPSDPLGRADKASDTSSETVFGKRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADNSCPNSKAPVLSKYPYSCRSQENILQGFSTSHKEGVNQPAAVVMEDSSPHEALRCRVIKSSGREKPDSDDDLDIASLVTAKLVNTTITPEPEPKPQPNSREKAKTRGAPRTSLFENDKDAGMENESVKSVRASTNTMELPDTNGAGVKSQRPFSPREALRSRAIIKPVIVDKDVKKIMGGSGTETTLEKQKPVSKPGPNKVTSSITIYPSDSSSPRAAPGEALRERHTSTSNIQVGLAELTSVSNHVSSPFELSIHKHDITLQLAEAERMADGPLKDRPETVVSRSSIIIKPSDPVERNSHAPPAETIRWKSHSAPSEVGFSDARHVTVRNAWKSRRDLKSLEDPPTRIGKNVESTNSNAYTQRSSTDFSELEQPRSCLFEQGTRRVGPSSGDAPEPSSRRTQSSLTVSEVLTRRNRVGDTITVAAWNHSASMEEEGEDCTLSVYRQLHNSLDPSELPGKQGLPESGRVRAEERLRPTRPCAEEN"},{"id":"SEQ_06154","a":"O43900","g":"PRICKLE3","d":"Prickle planar cell polarity protein 3","L":615,"m":[{"c":"CxxC(x){13,18}Gx[CH]WH(x){2,4}[CH]F[VC]CxxCxxxLxxxx[YF]φxxxxxx[YHF]C(x){2,3}[CH]","u":"52-57","sp":"periodic","x":"structured_like","cf":"high","why":"Three periodic 52-57 aa double zinc-binding repeats separated by regular 8-aa linkers, anchored by paired CxxC motifs, an internal Gx[CH]WH...(x){2,4}[CH]F[VC] signature, conserved hydrophobic positions (L and [YF]φ) in the 17-aa second loop, and a C-terminal [YHF]C(x){2,3}[CH] motif.","i":[[186,242,"CEECGKQIGGGDIAVFASRAGLGACWHPQCFVCTTCQELLVDLIYFYHVGKVYCGRH"],[251,302,"CQACDEIIFSPECTEAEGRHWHMDHFCCFECEASLGGQRYVMRQSRPHCCAC"],[311,366,"CDGCGEHIGLDQGQMAYEGQHWHASDRCFCCSRCGRALLGRPFLPRRGLIFCSRAC"]]}],"s":"MFARGSRRRRSGRAPPEAEDPDRGQPCNSCREQCPGFLLHGWRKICQHCKCPREEHAVHAVPVDLERIMCRLISDFQRHSISDDDSGCASEEYAWVPPGLKPEQVYQFFSCLPEDKVPYVNSPGEKYRIKQLLHQLPPHDSEAQYCTALEEEEKKELRAFSQQRKRENLGRGIVRIFPVTITGAICEECGKQIGGGDIAVFASRAGLGACWHPQCFVCTTCQELLVDLIYFYHVGKVYCGRHHAECLRPRCQACDEIIFSPECTEAEGRHWHMDHFCCFECEASLGGQRYVMRQSRPHCCACYEARHAEYCDGCGEHIGLDQGQMAYEGQHWHASDRCFCCSRCGRALLGRPFLPRRGLIFCSRACSLGSEPTAPGPSRRSWSAGPVTAPLAASTASFSAVKGASETTTKGTSTELAPATGPEEPSRFLRGAPHRHSMPELGLRSVPEPPPESPGQPNLRPDDSAFGRQSTPRVSFRDPLVSEGGPRRTLSAPPAQRRRPRSPPPRAPSRRRHHHHNHHHHHNRHPSRRRHYQCDAGSGSDSESCSSSPSSSSSESSEDDGFFLGERIPLPPHLCRPMPAQDTAMETFNSPSLSLPRDSRAGMPRQARDKNCIVA"},{"id":"SEQ_06167","a":"O94967","g":"WDR47","d":"WD repeat-containing protein 47","L":919,"m":[{"c":"[HD](x){3,5}[IV]xx[VLC]xx(x){3,9}xxφ[ASL]x[GS][SAQ]x[DS]xxxxxxxx","u":"30-36","sp":"periodic","x":"structured_like","cf":"high","why":"Seven C-terminal 30-36 aa beta-propeller core repeats arrayed with periodic outer-strand linkers, anchored by an N-terminal [HD](x){3,5}[IV] motif, two hydrophobic beta-strands ([VLC] and φ[ASL]), and a conserved [GS][SAQ]x[DS] tight turn.","i":[[605,635,"DTQAVRAVAFHPAGGLYAVGSNSKTLRVCAY"],[660,690,"HKGSIYCVAWSPCGQLLATGSNDKYVKVLPF"],[707,742,"HDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDC"],[754,783,"HTGHILALYTWSGWMIASGSQDKTVRFWDL"],[797,829,"HGTGSAVASVAVDPSGRLLATGQEDSSCMLYDI"],[841,871,"HSSDVRSVRFSPGAHYLLTGSYDMKIKVTDL"],[887,917,"HKDKVIQCRWHTQDLSFLSSSADRTVTLWTY"]]}],"s":"MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGLFSDDMLFLRQLILDGQWDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMSAEDEPQHLEFTMQEAVQCLHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTARVHCFEEACVMVAEFIPADRKLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGEEITESEVLLGIDLLCGNGCDDLDLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPTKAAYADLLTPLISKLSPYPSSPMRRPQSADAYMTRSLNPALDGLTCGLTSHDKRISDLGNKTSPMSHSFANFHYPGVQNLSRSLMLENTECHSIYEESPERDTPVDAQRPIGSEILGQSSVSEKEPANGAQNPGPAKQEKNELRDSTEQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQQQNLTEQFLNRSIQKLGELNIGMDGLGNEVSALNQQCNGSKGNGSNGSSVTSFTTPPQDSSQRLTHDASNIHTSTPRNPGSTNHIPFLEESPCGSQISSEHSVIKPPLGDSPGSLSRSKGEEDDKSKKQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLWTYNG"},{"id":"SEQ_06187","a":"O95785","g":"WIZ","d":"Protein 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hydrophobic residue (φ).","i":[[269,289,"CIECSIYFKQKEHLLEHMSQH"],[306,326,"CGECGWAFADPTALEQHRQLH"],[355,375,"CPKCVFGTNSSRAYVQHAKLH"],[418,439,"CVFCGFPAPSESLLREHVRLVH"],[703,723,"CPYCPDRFHNGIGLANHVRGH"]]}],"s":"MEGSLAGSLAAPDRPQGPERLPGPAPRENIEGGAEAAEGEGGIFRSTRYLPVTKEGPRDILDGRGGISGTPDGRGPWEHPLVQEAGEGILSERRFEDSVIVRTMKPHAELEGSRRFLHHRGEPRLLEKHAQGRPRFDWLQDEDEQGSPQDAGLHLDLPAQPPPLAPFRRVFVPVEDTPKTLDMAVVGGREDLEDLEGLAQPSEWGLPTSASEVATQTWTVNSEASVERLQPLLPPIRTGPYLCELLEEVAEGVASPDEDEDEEPAVFPCIECSIYFKQKEHLLEHMSQHRRAPGQEPPADLAPLACGECGWAFADPTALEQHRQLHQASREKIIEEIQKLKQVPGDEGREARLQCPKCVFGTNSSRAYVQHAKLHMREPPGQTTKEPFGGSSGAGSPSPEASALLYQPYGAAVGLSACVFCGFPAPSESLLREHVRLVHAHPHWEEDGEAYEEDPASQPGTSQDAHACFPDTAVDYFGKAEPSLAPMWRENPAGYDPSLAFGPGCQQLSIRDFPLSKPLLHGTGQRPLGRLAFPSTLASTPYSLQLGRNKSTVHPQGLGERRRPWSEEEEEEEEEEDVVLTSEMDFSPENGVFSPLATPSLIPQAALELKQAFREALQAVEATQGQQQQLRGMVPIVLVAKLGPQVMAAARVPPRLQPEELGLAGAHPLDFLLLDAPLGGPLGLDTLLDGDPAMALKHEERKCPYCPDRFHNGIGLANHVRGHLNRVGVSYNVRHFISAEEVKAIERRFSFQKKKKKVANFDPGTFSLMRCDFCGAGFDTRAGLSSHARAHLRDFGITNWELTVSPINILQELLATSAAEQPPSPLGREPGGPPGSFLTSRRPRLPLTVPFPPTWAEDPGPAYGDAQSLTTCEVCGACFETRKGLSSHARSHLRQLGVAESESSGAPIDLLYELVKQKGLPDAHLGLPPGLAKKSSSLKEVVAGAPRPGLLSLAKPLDAPAVNKAIKSPPGFSAKGLGHPPSSPLLKKTPLALAGSPTPKNPEDKSPQLSLSPRPASPKAQWPQSEDEGPLNLTSGPEPARDIRCEFCGEFFENRKGLSSHARSHLRQMGVTEWYVNGSPIDTLREILKRRTQSRPGGPPNPPGPSPKALAKMMGGAGPGSSLEARSPSDLHISPLAKKLPPPPGSPLGHSPTASPPPTARKMFPGLAAPSLPKKLKPEQIRVEIKREMLPGALHGELHPSEGPWGAPREDMTPLNLSSRAEPVRDIRCEFCGEFFENRKGLSSHARSHLRQMGVTEWSVNGSPIDTLREILKKKSKPCLIKKEPPAGDLAPALAEDGPPTVAPGPVQSPLPLSPLAGRPGKPGAGPAQVPRELSLTPITGAKPSATGYLGSVAAKRPLQEDRLLPAEVKAKTYIQTELPFKAKTLHEKTSHSSTEACCELCGLYFENRKALASHARAHLRQFGVTEWCVNGSPIETLSEWIKHRPQKVGAYRSYIQGGRPFTKKFRSAGHGRDSDKRPSLGLAPGGLAVVGRSAGGEPGPEAGRAADGGERPLAASPPGTVKAEEHQRQNINKFERRQARPPDASAARGGEDTNDLQQKLEEVRQPPPRVRPVPSLVPRPPQTSLVKFVGNIYTLKCRFCEVEFQGPLSIQEEWVRHLQRHILEMNFSKADPPPEESQAPQAQTAAAEAP"},{"id":"SEQ_06189","a":"P52736","g":"ZNF133","d":"Zinc finger protein 133","L":654,"m":[{"c":"[PT]xxCxxC[GE]x[GSC]Fxxx[STA]x[LV]xxHxxx[HT][STL]x[EH][KRH]","u":28,"sp":"tandem","x":"structured_like","cf":"high","why":"Unbroken 420-residue head-to-tail tandem array of 15 28-residue units defined by invariant CxxC, F, and H anchors, a conserved aliphatic [LV] position, and a strongly conserved [STL]x[EH][KRH]-[PT]xx junction between adjacent copies.","i":[[213,240,"TVNCGECGLSFSKMTNLLSHQRIHSGEK"],[241,268,"PYVCGVCEKGFSLKKSLARHQKAHSGEK"],[269,296,"PIVCRECGRGFNRKSTLIIHERTHSGEK"],[297,324,"PYMCSECGRGFSQKSNLIIHQRTHSGEK"],[325,352,"PYVCRECGKGFSQKSAVVRHQRTHLEEK"],[353,380,"TIVCSDCGLGFSDRSNLISHQRTHSGEK"],[381,408,"PYACKECGRCFRQRTTLVNHQRTHSKEK"],[409,436,"PYVCGVCGHSFSQNSTLISHRRTHTGEK"],[437,464,"PYVCGVCGRGFSLKSHLNRHQNIHSGEK"],[465,492,"PIVCKDCGRGFSQQSNLIRHQRTHSGEK"],[493,520,"PMVCGECGRGFSQKSNLVAHQRTHSGER"],[521,548,"PYVCRECGRGFSHQAGLIRHKRKHSREK"],[549,576,"PYMCRQCGLGFGNKSALITHKRAHSEEK"],[577,604,"PCVCRECGQGFLQKSHLTLHQMTHTGEK"],[605,632,"PYVCKTCGRGFSLKSHLSRHRKTTSVHH"]]}],"s":"MAFRDVAVDFTQDEWRLLSPAQRTLYREVMLENYSNLVSLGISFSKPELITQLEQGKETWREEKKCSPATCPADPEPELYLDPFCPPGFSSQKFPMQHVLCNHPPWIFTCLCAEGNIQPGDPGPGDQEKQQQASEGRPWSDQAEGPEGEGAMPLFGRTKKRTLGAFSRPPQRQPVSSRNGLRGVELEASPAQSGNPEETDKLLKRIEVLGFGTVNCGECGLSFSKMTNLLSHQRIHSGEKPYVCGVCEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNRKSTLIIHERTHSGEKPYMCSECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSAVVRHQRTHLEEKTIVCSDCGLGFSDRSNLISHQRTHSGEKPYACKECGRCFRQRTTLVNHQRTHSKEKPYVCGVCGHSFSQNSTLISHRRTHTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGEKPIVCKDCGRGFSQQSNLIRHQRTHSGEKPMVCGECGRGFSQKSNLVAHQRTHSGERPYVCRECGRGFSHQAGLIRHKRKHSREKPYMCRQCGLGFGNKSALITHKRAHSEEKPCVCRECGQGFLQKSHLTLHQMTHTGEKPYVCKTCGRGFSLKSHLSRHRKTTSVHHRLPVQPDPEPCAGQPSDSLYSL"},{"id":"SEQ_06198","a":"O43182","g":"ARHGAP6","d":"Rho GTPase-activating protein 6","L":974,"m":[{"c":"WxxW[HQE]","u":5,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Four copies of a 5-residue tryptophan motif in the C-terminal disordered region anchored by invariant W at positions 1 and 4 and a polar/acidic residue ([HQE]) at position 5, occurring as two dispersed upstream copies and a closely spaced C-terminal pair.","i":[[735,739,"WGTWH"],[780,784,"WPRWQ"],[947,951,"WLDWQ"],[955,959,"WQIWE"]]}],"s":"MSAQSLLHSVFSCSSPASSSAASAKGFSKRKLRQTRSLDPALIGGCGSDEAGAEGSARGATAGRLYSPSLPAESLGPRLASSSRGPPPRATRLPPPGPLCSSFSTPSTPQEKSPSGSFHFDYEVPLGRGGLKKSMAWDLPSVLAGPASSRSASSILCSSGGGPNGIFASPRRWLQQRKFQSPPDSRGHPYVVWKSEGDFTWNSMSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRAYKLKQDLQRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFSVGGRHSSTDSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPGQFMLVGHLSSSKSRESSPGPRLGKDLSEEPFDIWGTWHSTLKSGSKDPGMTGSSGDIFESSSLRAGPCSLSQGNLSPNWPRWQGSPAELDSDTQGARRTQAAAPATEGRAHPAVSRACSTPHVQVAGKAERPTARSEQYLTLSGAHDLSESELDVAGLQSRATPQCQRPHGSGRDDKRPPPPYPGPGKPAAAAAWIQGPPEGVETPTDQGGQAAEREQQVTQKKLSSANSLPAGEQDSPRLGDAGWLDWQRERWQIWELLSTDNPDALPETLV"},{"id":"SEQ_06200","a":"Q96QE3","g":"ATAD5","d":"ATPase family AAA domain-containing protein 5","L":1844,"m":[{"c":"SP+K[IV]","u":5,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Three tandem 5-aa copies separated by 1-2 aa gaps within a P/S/K-rich disordered linker, sharing fixed S1, P2, and K4 anchors alongside conserved basic [KR]3 and beta-branched aliphatic [IV]5 positions.","i":[[1201,1205,"SPKKI"],[1207,1211,"SPKKV"],[1214,1218,"SPRKV"]]}],"s":"MVGVLAMAAAAAPPPVKDCEIEPCKKRKKDDDTSTCKTITKYLSPLGKTRDRVFAPPKPSNILDYFRKTSPTNEKTQLGKECKIKSPESVPVDSNKDCTTPLEMFSNVEFKKKRKRVNLSHQLNNIKTENEAPIEISSDDSKEDYSLNNDFVESSTSVLRYKKQVEVLAENIQDTKSQPNTMTSLQNSKKVNPKQGTTKNDFKKLRKRKCRDVVDLSESLPLAEELNLLKKDGKDTKQMENTTSHANSRDNVTEAAQLNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSETVDEIVKSGYISESENSEISQQVRFKTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTVQKRKSNVVIQEEELELAVLEAGSSEAVKPKCTLEERQQFMKAFRQPASDALKNGVKKSSDKQKDLNEKCLYEVGRDDNSKKIMENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGNTQKKETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVKDIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTETIRGIDSDDVQDNSQLKASTQKAANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGGFTSQIRKASNTSKNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVLGKKLNTSTKNVPGKMKVAPLFLVRKAQKAADPVPSFDESSQDTSEKSQDCDVQCKAKRDFLMSGLPDLLKRQIAKKAAALDVYNAVSTSFQRVVHVQQKDDGCCLWHLKPPSCPLLTKFKELNTKVIDLSKCGIALGEFSTLNSKLKSGNSAAVFMRTRKEFTEEVRNLLLEEIRWSNPEFSLKKYFPLLLKKQIEHQVLSSECHSKQELEADVSHKETKRKLVEAENSKSKRKKPNEYSKNLEKTNRKSEELSKRNNSSGIKLDSSKDSGTEDMLWTEKYQPQTASELIGNELAIKKLHSWLKDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEESRLCNTVLITGPTGVGKTAAVYACAQELGFKIFEVNASSQRSGRQILSQLKEATQSHQVDKQGVNSQKPCFFNSYYIGKSPKKISSPKKVVTSPRKVPPPSPKSSGPKRALPPKTLANYFKVSPKPKNNEEIGMLLENNKGIKNSFEQKQITQTKSTNATNSNVKDVGAEEPSRKNATSLILFEEVDVIFDEDAGFLNAIKTFMATTKRPVILTTSDPTFSLMFDGCFEEIKFSTPSLLNVASYLQMICLTENFRTDVKDFVTLLTANTCDIRKSILYLQFWIRSGGGVLEERPLTLYRGNSRNVQLVCSEHGLDNKIYPKNTKKKRVDLPKCDSGCAETLFGLKNIFSPSEDLFSFLKHKITMKEEWHKFIQLLTEFQMRNVDFLYSNLEFILPLPVDTIPETKNFCGPSVTVDASAATKSMNCLARKHSEREQPLKKSQKKKQKKTLVILDDSDLFDTDLDFPDQSISLSSVSSSSNAEESKTGDEESKARDKGNNPETKKSIPCPPKTTAGKKCSALVSHCLNSLSEFMDNMSFLDALLTDVREQNKYGRNDFSWTNGKVTSGLCDEFSLESNDGWTSQSSGELKAAAEALSFTKCSSAISKALETLNSCKKLGRDPTNDLTFYVSQKRNNVYFSQSAANLDNAWKRISVIKSVFSSRSLLYVGNRQASIIEYLPTLRNICKTEKLKEQGKSKRRFLHYFEGIHLDIPKETVNTLAADFP"},{"id":"SEQ_06203","a":"P43243","g":"MATR3","d":"Matrin-3","L":847,"m":[{"c":"RVψHψxxφxxxxxxxxxψLxLφEPΩGxIxNxψψψxxxoxAFIEMxTxEDAxAφVDxxxxxxφφφxG+xV+VxLSxKYK+ψ","u":80,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two ungapped 80-aa structured repeats separated by an 18-aa linker share 30 exact identities (including RVxH, LφEPΩGxIxN, AFIEMxTxEDAxAφVD, and LSxKYK+ψ) plus 15 physicochemically conserved positions.","i":[[398,477,"RVVHIMDFQRGKNLRYQLLQLVEPFGVISNHLILNKINEAFIEMATTEDAQAAVDYYTTTPALVFGKPVRVHLSQKYKRI"],[496,575,"RVIHLSNLPHSGYSDSAVLKLAEPYGKIKNYILMRMKSQAFIEMETREDAMAMVDHCLKKALWFQGRCVKVDLSEKYKKL"]]},{"c":"ψPK(x){4,5}CxxCxL(x){10,11}HxxxxxH","u":31,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two 31-aa cysteine/histidine-anchored repeats in the N- and C-terminal regions share an N-terminal ψPK motif, a CxxCxL core, a central NxE-containing segment, and a C-terminal HxxxxxH dyad.","i":[[285,315,"LPKGYPHLCSICDLPVHSNKEWSQHINGASH"],[796,826,"IPKTGFYCKLCSLFYTNEEVAKNTHCSSLPH"]]},{"c":"DGKxxPSDKxxKxDGS","u":16,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Internal duplication in the C-terminal polar/charged disordered region with 11/16 ungapped exact amino acid identities (DGK, PSDK, K, and DGS anchors).","i":[[600,615,"DGKESPSDKKSKTDGS"],[690,705,"DGKKEPSDKAVKKDGS"]]}],"s":"MSKSFQQSSLSRDSQGHGRDLSAAGIGLLAAATQSLSMPASLGRMNQGTARLASLMNLGMSSSLNQQGAHSALSSASTSSHNLQSIFNIGSRGPLPLSSQHRGDADQASNILASFGLSARDLDELSRYPEDKITPENLPQILLQLKRRRTEEGPTLSYGRDGRSATREPPYRVPRDDWEEKRHFRRDSFDDRGPSLNPVLDYDHGSRSQESGYYDRMDYEDDRLRDGERCRDDSFFGETSHNYHKFDSEYERMGRGPGPLQERSLFEKKRGAPPSSNIEDFHGLLPKGYPHLCSICDLPVHSNKEWSQHINGASHSRRCQLLLEIYPEWNPDNDTGHTMGDPFMLQQSTNPAPGILGPPPPSFHLGGPAVGPRGNLGAGNGNLQGPRHMQKGRVETSRVVHIMDFQRGKNLRYQLLQLVEPFGVISNHLILNKINEAFIEMATTEDAQAAVDYYTTTPALVFGKPVRVHLSQKYKRIKKPEGKPDQKFDQKQELGRVIHLSNLPHSGYSDSAVLKLAEPYGKIKNYILMRMKSQAFIEMETREDAMAMVDHCLKKALWFQGRCVKVDLSEKYKKLVLRIPNRGIDLLKKDKSRKRSYSPDGKESPSDKKSKTDGSQKTESSTEGKEQEEKSGEDGEKDTKDDQTEQEPNMLLESEDELLVDEEEAAALLESGSSVGDETDLANLGDVASDGKKEPSDKAVKKDGSASAAAKKKLKKVDKIEELDQENEAALENGIKNEENTEPGAESSENADDPNKDTSENADGQSDENKDDYTIPDEYRIGPYQPNVPVGIDYVIPKTGFYCKLCSLFYTNEEVAKNTHCSSLPHYQKLKKFLNKLAEERRQKKET"},{"id":"SEQ_06205","a":"Q9Y2G4","g":"ANKRD6","d":"Ankyrin repeat domain-containing protein 6","L":727,"m":[{"c":"[GD]xT[APC]L[HE]xAxxx[GNS]xxxxxxφLxx[AE]xxxxxxxxxx","u":33,"sp":"tandem","x":"structured_like","cf":"high","why":"Seven head-to-tail 33-aa structured repeats conserved at the [GD]xT[APC]L[HE]xA signature and the downstream φLxx[AE] hydrophobic helix core; C-terminal amphipathic heptad tracts are flagged separately as coiled_coil_heptad.","i":[[42,74,"GRTPLHLAANKGHLPVVQILLKAGCDLDVQDDG"],[75,107,"DQTALHRATVVGNTEIIAALIHEGCALDRQDKD"],[108,140,"GNTALHEASWHGFSQSAKLLIKAGANVLAKNKA"],[141,173,"GNTALHLACQNSHSQSTRVLLLAGSRADLKNNA"],[174,206,"GDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQA"],[207,239,"GDTALHVAAALNHKKVAKILLEAGADTTIVNNA"],[240,272,"GQTPLETARYHNNPEVALLLTKAPQVLRFSRGR"]]}],"s":"MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLIKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINKLENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRLQQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTCESSTGVDQLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPMNEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRDTSQALELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLRTRVQKEN"},{"id":"SEQ_06213","a":"Q8NAX2","g":"KDF1","d":"Keratinocyte differentiation factor 1","L":398,"m":[{"c":"φ[RQ][RG]CxxC","u":7,"sp":"tandem","x":"structured_like","cf":"high","why":"Three contiguous 7-aa tandem repeats anchored by invariant CxxC cysteines at positions 4 and 7, a conserved hydrophobic residue (F/L/V) at position 1, and [RQ][RG] at positions 2-3.","i":[[92,98,"FRRCRDC"],[99,105,"LQRCGAC"],[106,112,"VRGCSPC"]]}],"s":"MPRPGHPRPASGPPRLGPWERPTELCLETYDKPPQPPPSRRTRRPDPKDPGHHGPESITFISGSAEPALESPTCCLLWRPWVWEWCRAAFCFRRCRDCLQRCGACVRGCSPCLSTEDSTEGTAEANWAKEHNGVPPSPDRAPPSRRDGQRLKSTMGSSFSYPDVKLKGIPVYPYPRATSPAPDADSCCKEPLADPPPMRHSLPSTFASSPRGSEEYYSFHESDLDLPEMGSGSMSSREIDVLIFKKLTELFSVHQIDELAKCTSDTVFLEKTSKISDLISSITQDYHLDEQDAEGRLVRGIIRISTRKSRARPQTSEGRSTRAAAPTAAAPDSGHETMVGSGLSQDELTVQISQETTADAIARKLRPYGAPGYPASHDSSFQGTDTDSSGAPLLQVYC"},{"id":"SEQ_06217","a":"A4D1P6","g":"WDR91","d":"WD repeat-containing protein 91","L":747,"m":[{"c":"xxxxxψxxxxxxx(x){1,17}xxφφxxxxx(x){0,23}GxφxφΩxx","u":"31-54","sp":"periodic","x":"structured_like","cf":"high","why":"Seven periodic structured repeats in the C-terminal half separated by regular 10-15 aa linkers, anchored by a conserved hydrophobic dipeptide (φφ) and an invariant Gly followed by a hydrophobic-aromatic core (GxφxφΩxx), with loop insertions in copies 3 and 6.","i":[[407,437,"HHSSIMHCRVDCSGRRVASLDVDGVIKVWSF"],[450,480,"KSPLLSLEWATKRDRLLLLGSGVGTVRLYDT"],[494,547,"NMPRILSLACSPNGASFVCSAAAPSLTSQVDFSAPDIGSKGMNQVPGRLLLWDT"],[560,591,"PEPIAINCTAFNHNGNLLVTGAADGVIRLFDM"],[602,633,"AHYGEVYSVEFSYDENTVYSIGEDGKFIQWNI"],[649,695,"ATGPFVLSGYSGYKQVQVPRGRLFAFDSEGNYMLTCSATGGVIYKLG"],[709,742,"GHRAPVVTVDWSTAMDCGTCLTASMDGKIKLTTL"]]}],"s":"MAEAVERTDELVREYLLFRGFTHTLRQLDAEIKADKEKGFRVDKIVDQLQQLMQVYDLAALRDYWSYLERRLFSRLEDIYRPTIHKLKTSLFRFYLVYTIQTNRNDKAQEFFAKQATELQNQAEWKDWFVLPFLPSPDTNPTFATYFSRQWADTFIVSLHNFLSVLFQCMPVPVILNFDAECQRTNQVQEENEVLRQKLFALQAEIHRLKKEEQQPEEEEALVQHKLPPYVSNMDRLGDSELAMVCSQRNASLSQSPRVGFLSSLLPQSKKSPSRLSPAQGPPQPQSSAKKESFGGQGTKGKDPTSGAKDGKSLLSGLATGESGWSQHRQRRLQDHGKERKELFSTTTSQCAEKKPEASGPEAEPCPELHTEPVEPLTRASSAGPEGGGVRPEQPFIVLGQEEYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLLLLGSGVGTVRLYDTEAKKNLCEININDNMPRILSLACSPNGASFVCSAAAPSLTSQVDFSAPDIGSKGMNQVPGRLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIHKSGLKVSEYSLPSDATGPFVLSGYSGYKQVQVPRGRLFAFDSEGNYMLTCSATGGVIYKLGGDEKVLESCLSLGGHRAPVVTVDWSTAMDCGTCLTASMDGKIKLTTLLAHKA"},{"id":"SEQ_06222","a":"Q9UKF5","g":"ADAM29","d":"Disintegrin and metalloproteinase domain-containing protein 29","L":820,"m":[{"c":"Q[SR][QH]Px[VL][MT]PS","u":9,"sp":"tandem","x":"disordered_like","cf":"high","why":"Ten head-to-tail tandem 9-aa repeats spanning the C-terminal disordered tail (residues 731-820), strictly anchored by invariant Q1, P4, P8, and S9 plus hydrophobic [VL]6 and [MT]7 positions, organized in an alternating odd/even 18-aa dimeric pattern.","i":[[731,739,"QSQPWVMPS"],[740,748,"QSQPPVTPS"],[749,757,"QSHPQVMPS"],[758,766,"QSQPPVTPS"],[767,775,"QSQPRVMPS"],[776,784,"QSQPPVMPS"],[785,793,"QSHPQLTPS"],[794,802,"QSQPPVTPS"],[803,811,"QRQPQLMPS"],[812,820,"QSQPPVTPS"]]}],"s":"MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEKIQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPPVMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS"},{"id":"SEQ_06226","a":"Q68DN1","g":"SPATA31H1","d":"Spermatogenesis-associated protein 31H1","L":1984,"m":[{"c":"[SG]PS[EQ]R[SR]H[RHC]","u":8,"sp":"tandem","x":"disordered_like","cf":"high","why":"Extensive C-terminal disordered-like octapeptide tandem repeat array (aa 1552-1934, including 34 consecutive head-to-tail copies) strongly anchored by P at position 2, E/Q at position 4, invariant R at position 5, H at position 7, and R/H/C at position 8.","i":[[1552,1559,"GPSERTRH"],[1560,1567,"NPSWRNHR"],[1568,1575,"SPSERSQR"],[1576,1583,"SSLERRHH"],[1584,1591,"SPSQRSHC"],[1592,1599,"SPSRKNHS"],[1600,1607,"SPSERSWR"],[1608,1615,"SPSQRNHC"],[1616,1623,"SPPERSCH"],[1624,1631,"SLSERGLH"],[1632,1639,"SPSQRSHR"],[1640,1647,"GPSQRRHH"],[1648,1655,"SPSERSHR"],[1656,1663,"SPSERSHR"],[1664,1671,"SSSERRHR"],[1672,1679,"SPSQRSHR"],[1680,1687,"GPSERSHC"],[1688,1695,"SPSERRHR"],[1696,1703,"SPSQRSHR"],[1704,1711,"GPSERRHH"],[1712,1719,"SPSKRSHR"],[1720,1727,"SPARRSHR"],[1728,1735,"SPSERSHH"],[1736,1743,"SPSERSHH"],[1744,1751,"SPSERRHH"],[1752,1759,"SPSERSHC"],[1760,1767,"SPSERSHC"],[1768,1775,"SPSERRHR"],[1776,1783,"SPSERRHH"],[1784,1791,"SPSEKSHH"],[1792,1799,"SPSERSHH"],[1800,1807,"SPSERRRH"],[1808,1815,"SPLERSRH"],[1816,1823,"SLLERSHR"],[1847,1854,"SPSEKSHL"],[1855,1862,"SPLERSRC"],[1863,1870,"SPSERRGH"],[1879,1886,"SPSERSHR"],[1895,1902,"RTSERSHR"],[1903,1910,"SSCERTRH"],[1919,1926,"RPSGRNHC"],[1927,1934,"SPSERSRR"]]},{"c":"[KE]xφ[EG]ψ[TI][PS]xxxx[QHR]φx","u":14,"sp":"tandem","x":"mixed","cf":"high","why":"Large N-terminal 14-residue tandem repeat domain spanning aa 61-685 in long head-to-tail blocks (with occasional short linkers or 11-13 aa indel variants), defined by conserved K/E at position 1, hydrophobic position 3, [EG]-ψ-[TI]-[PS] core at positions 4-7, and Q/H/R-φ at positions 12-13.","i":[[61,74,"KSLEFTVEPKLQSV"],[75,88,"KHVKLSSVSLQQTI"],[89,102,"KSVELAPGSLPQRV"],[103,116,"KYGEQTPRTNYQIM"],[117,130,"ESSELIPRPGHQFA"],[131,144,"KYAEMIPQPKYQIP"],[145,158,"KSANLISIPIYHAT"],[159,172,"ESSEMAQGLAYKGI"],[177,190,"KSVGLTPKLTGRAK"],[191,204,"ESLGMLLQPDLQVP"],[205,218,"KFVDLTPMVRDQGS"],[219,232,"KFLGLTPEKSYQIL"],[233,246,"ETMELLSQSRPRVK"],[247,260,"DVGELYMKPLQQTV"],[261,274,"EYEGITPELKHYFT"],[275,288,"EAMGLTAEARIQAN"],[289,302,"EFFGMTPKPTSQAT"],[303,316,"GFAERSPRLCPQNL"],[317,330,"ECVEVISEKRLQGE"],[331,344,"ESVVLIPKSLHHVP"],[346,359,"SASGMTPGLGHRVP"],[360,373,"ESVELTSKSGVQVE"],[374,387,"KTLQLTPKPQHHVG"],[401,414,"ESVNLTCKQWLQME"],[415,428,"ESLEVPLKQTSQVI"],[445,458,"EVSMGLTKSKNQSM"],[459,472,"KSPGTTPGPLGRIV"],[473,486,"EFMRISPEPLDQVT"],[564,577,"KSTKLITKPKHQIL"],[602,615,"KSEELAPGPIPQVV"],[630,643,"NCVDLLPRPHLQEL"],[658,671,"KSAELTSPQTSPFE"],[672,685,"EHTILTHKQGLQAV"]]}],"s":"MELTPGAQQQGINYQELTSGWQDVKSMMLVPEPTRKFPSGPLLTSVRFSNLSPESQQQDVKSLEFTVEPKLQSVKHVKLSSVSLQQTIKSVELAPGSLPQRVKYGEQTPRTNYQIMESSELIPRPGHQFAKYAEMIPQPKYQIPKSANLISIPIYHATESSEMAQGLAYKGIDTVEKSVGLTPKLTGRAKESLGMLLQPDLQVPKFVDLTPMVRDQGSKFLGLTPEKSYQILETMELLSQSRPRVKDVGELYMKPLQQTVEYEGITPELKHYFTEAMGLTAEARIQANEFFGMTPKPTSQATGFAERSPRLCPQNLECVEVISEKRLQGEESVVLIPKSLHHVPDSASGMTPGLGHRVPESVELTSKSGVQVEKTLQLTPKPQHHVGSPGIISGLGHQVPESVNLTCKQWLQMEESLEVPLKQTSQVIGHEESVELTSEARQHREVSMGLTKSKNQSMKSPGTTPGPLGRIVEFMRISPEPLDQVTESARTQLQVAQSEEVILIDVPKVVQSVKVTPGPPFQIVKSVTIPRPTPQMVEYIELTPKLQYVRPSEHHTGPCLQDVKSTKLITKPKHQILETVELTGFQIVKTMLIPGPSLQIVKSEELAPGPIPQVVEPIGVALESGIEAINCVDLLPRPHLQELIVPAELTPSPCTQVKSAELTSPQTSPFEEHTILTHKQGLQAVKSTVIKTEPPKVMETEDLNLGHVCQNRDCQKLTSEELQVGTDFSRFLQSSSTTLISSSVRTASELGGLWDSGIQEVSRALDIKNPGTDILQPEETYIDPTMIQSLTFPLALHNQSSDKTANIVENPCPEILGVDVISKETTKRKQMEELENSLQRHLPQSWRSRSRTFQAESGVQKGLIKSFPGRQHNVWESHAWRQRLPRKYLSTMLMLGNILGTTMERKLCSQTSLAERATADTCQSIQNLFGIPAELMEPSQSLPEKGPVTISQPSVVKNYIQRHTFYHGHKKRMALRIWTRGSTSSIIQQYSGTRVRIKKTNSTFNGISQEVIQHMPVSCAGGQLPVLVKSESSLSIFYDREDLVPMEESEDSQSDSQTRISESQHSLKPNYLSQAKTDFSEQFQLLEDLQLKIAAKLLRSQIPPDVPPPLASGLVLKYPICLQCGRCSGLNCHHKLQTTSGPYLLIYPQLHLVRTPEGHGEVRLHLGFRLRIGKRSQISKYRERDRPVIRRSPISPSQRKAKIYTQASKSPTSTIDLQSGPSQSPAPVQVYIRRGQRSRPDLVEKTKTRAPGHYEFTQVHNLPESDSESTQNEKRAKVRTKKTSDSKYPMKRITKRLRKHRKFYTNSRTTIESPSRELAAHLRRKRIGATQTSTASLKRQPKKPSQPKFMQLLFQSLKRAFQTAHRVIASVGRKPVDGTRPDNLWASKNYYPKQNARDYCLPSSIKRDKRSADKLTPAGSTIKQEDILWGGTVQCRSAQQPRRAYSFQPRPLRLPKPTDSQSGIAFQTASVGQPLRTVQKDSSSRSKKNFYRNETSSQESKNLSTPGTRVQARGRILPGSPVKRTWHRHLKDKLTHKEHNHPSFYRERTPRGPSERTRHNPSWRNHRSPSERSQRSSLERRHHSPSQRSHCSPSRKNHSSPSERSWRSPSQRNHCSPPERSCHSLSERGLHSPSQRSHRGPSQRRHHSPSERSHRSPSERSHRSSSERRHRSPSQRSHRGPSERSHCSPSERRHRSPSQRSHRGPSERRHHSPSKRSHRSPARRSHRSPSERSHHSPSERSHHSPSERRHHSPSERSHCSPSERSHCSPSERRHRSPSERRHHSPSEKSHHSPSERSHHSPSERRRHSPLERSRHSLLERSHRSPSERRSHRSFERSHRRISERSHSPSEKSHLSPLERSRCSPSERRGHSSSGKTCHSPSERSHRSPSGMRQGRTSERSHRSSCERTRHSPSEMRPGRPSGRNHCSPSERSRRSPLKEGLKYSFPGERPSHSLSRDFKNQTTLLGTTHKNPKAGQVWRPEATR"},{"id":"SEQ_06227","a":"Q12986","g":"NFX1","d":"Transcriptional repressor NF-X1","L":1120,"m":[{"c":"CxxxC(x){5,8}C(x){1,6}HxCxxxCHx[GQ]xC[GPQ][PQT]C(x){7,9}C(x){1,2}C[GS](x){7,17}C","u":"47-60","sp":"dispersed","x":"structured_like","cf":"high","why":"Five complete 47-60 aa cysteine/histidine-rich modules sharing 10 invariant cysteines and 2 invariant histidines (CxxxC, HxC, CH, C[GPQ][PQT]C, and C[GS] anchors) separated by variable 6-38 aa linkers in the central region.","i":[[440,488,"CGEVCRKKQPGQDCPHSCNLLCHPGPCPPCPAFMTKTCECGRTRHTVRC"],[496,542,"CSNPCENILNCGQHQCAELCHGGQCQPCQIILNQVCYCGSTSRDVLC"],[557,615,"CLKICGKDLKCGNHTCSQVCHPQPCQQCPRLPQLVRCCPCGQTPLSQLLELGSSSRKTC"],[622,672,"CGKVCGKPLPCGSLDFIHTCEKLCHEGDCGPCSRTSVISCRCSFRTKELPC"],[711,761,"CPLICGRKLRCGLHRCEEPCHRGNCQTCWQASFDELTCHCGASVIYPPVPC"]]}],"s":"MAEAPPVSGTFKFNTDAAEFIPQEKKNSGLNCGTQRRLDSNRIGRRNYSSPPPCHLSRQVPYDEISAVHQHSYHPSGSKPKSQQTSFQSSPCNKSPKSHGLQNQPWQKLRNEKHHIRVKKAQSLAEQTSDTAGLESSTRSESGTDLREHSPSESEKEVVGADPRGAKPKKATQFVYSYGRGPKVKGKLKCEWSNRTTPKPEDAGPESTKPVGVFHPDSSEASSRKGVLDGYGARRNEQRRYPQKRPPWEVEGARPRPGRNPPKQEGHRHTNAGHRNNMGPIPKDDLNERPAKSTCDSENLAVINKSSRRVDQEKCTVRRQDPQVVSPFSRGKQNHVLKNVETHTGSLIEQLTTEKYECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQADGQSGWRCPACQNVSAHVPNTYTCFCGKVKNPEWSRNEIPHSCGEVCRKKQPGQDCPHSCNLLCHPGPCPPCPAFMTKTCECGRTRHTVRCGQAVSVHCSNPCENILNCGQHQCAELCHGGQCQPCQIILNQVCYCGSTSRDVLCGTDVGKSDGFGDFSCLKICGKDLKCGNHTCSQVCHPQPCQQCPRLPQLVRCCPCGQTPLSQLLELGSSSRKTCMDPVPSCGKVCGKPLPCGSLDFIHTCEKLCHEGDCGPCSRTSVISCRCSFRTKELPCTSLKSEDATFMCDKRCNKKRLCGRHKCNEICCVDKEHKCPLICGRKLRCGLHRCEEPCHRGNCQTCWQASFDELTCHCGASVIYPPVPCGTRPPECTQTCARVHECDHPVYHSCHSEEKCPPCTFLTQKWCMGKHEFRSNIPCHLVDISCGLPCSATLPCGMHKCQRLCHKGECLVDEPCKQPCTTPRADCGHPCMAPCHTSSPCPVTACKAKVELQCECGRRKEMVICSEASSTYQRIAAISMASKITDMQLGGSVEISKLITKKEVHQARLECDEECSALERKKRLAEAFHISEDSDPFNIRSSGSKFSDSLKEDARKDLKFVSDVEKEMETLVEAVNKGKNSKKSHSFPPMNRDHRRIIHDLAQVYGLESVSYDSEPKRNVVVTAIRGKSVCPPTTLTGVLEREMQARPPPPIPHHRHQSDKNPGSSNLQKITKEPIIDYFDVQD"},{"id":"SEQ_06243","a":"O75554","g":"WBP4","d":"WW domain-binding protein 4","L":376,"m":[{"c":"KxxWVEGψ[ST]x-GΩxYYY[DN]xx[ST]GxSxWEKP-xF","u":32,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two highly conserved 32-aa structured repeats (50% identical, 23/32 positions physicochemically conserved) anchored by KxxWVEG, a central GΩxYYY aromatic tract, and a C-terminal WEKP-xF motif separated by a 9-aa linker.","i":[[125,156,"KGRWVEGITSEGYHYYYDLISGASQWEKPEGF"],[166,197,"KTVWVEGLSEDGFTYYYNTETGESRWEKPDDF"]]}],"s":"MADYWKSQPKKFCDYCKCWIADNRPSVEFHERGKNHKENVAKRISEIKQKSLDKAKEEEKASKEFAAMEAAALKAYQEDLKRLGLESEILEPSITPVTSTIPPTSTSNQQKEKKEKKKRKKDPSKGRWVEGITSEGYHYYYDLISGASQWEKPEGFQGDLKKTAVKTVWVEGLSEDGFTYYYNTETGESRWEKPDDFIPHTSDLPSSKVNENSLGTLDESKSSDSHSDSDGEQEAEEGGVSTETEKPKIKFKEKNKNSDGGSDPETQKEKSIQKQNSLGSNEEKSKTLKKSNPYGEWQEIKQEVESHEEVDLELPSTENEYVSTSEADGGGEPKVVFKEKTVTSLGVMADGVAPVFKKRRTENGKSRNLRQRGDDQ"},{"id":"SEQ_06246","a":"Q86X53","g":"ERICH1","d":"Glutamate-rich protein 1","L":443,"m":[{"c":"[EQ]E-xxx[AST]x","u":8,"sp":"tandem","x":"disordered_like","cf":"high","why":"Contiguous 16-copy head-to-tail 8-aa tandem array (residues 207-334) in an acidic disordered region, strictly phased by an N-terminal [EQ]E[DE] triad and position-7 [AST] anchor across recurrent GADAS, PTxAG, [VG]KD[TA]R, GVDT[SI], and LTRA[RG] unit variants.","i":[[207,214,"EEDGVDTS"],[215,222,"EEDPTLAG"],[223,230,"EEDVKDTR"],[231,238,"EEDGADAS"],[239,246,"EEDLTRAR"],[247,254,"QEEGADAS"],[255,262,"EEDPTPAG"],[263,270,"EEDVKDAR"],[271,278,"EEDGVDTI"],[279,286,"EEDLTRAG"],[287,294,"EEDGKDTR"],[295,302,"EEDGADAS"],[303,310,"EEDPTWAG"],[311,318,"EEEGADSG"],[319,326,"EEDGADAS"],[327,334,"EEDDTITN"]]}],"s":"MAAHRKHVFVEKVLQRLFPPVPSGQGKREPQTLAVQNPPKKVTSEKVSQKHAEPLTDTGSETPTARRLYTASGPPEGYVPCWPEPSSCGSPENASSGDDTEDQDPHDQPKRRRIRKHKSKKKFKNPNNVLIEQAELEKQQSLLQEKSQRQHTDGTTISKNKKRKLKKKQQIKRKKAAGLAAKAAGVSFMYQPEDSSNEGEGVGEACEEDGVDTSEEDPTLAGEEDVKDTREEDGADASEEDLTRARQEEGADASEEDPTPAGEEDVKDAREEDGVDTIEEDLTRAGEEDGKDTREEDGADASEEDPTWAGEEEGADSGEEDGADASEEDDTITNEKAHSILNFLKSTQEMYFYDGVSRDAASAALADAAEELLDRLASHSMLPSDVSILYHMKTLLLLQDTERLKHALEMFPEHCTMPPDHARVISAFFSYWITHILPEKSSD"},{"id":"SEQ_06249","a":"O15389","g":"SIGLEC5","d":"Sialic acid-binding Ig-like lectin 5","L":551,"m":[{"c":"C(x){3,5}P[PA]xxφ[SC]W(x){30,42}φ[ST]Cxφ","u":"46-60","sp":"dispersed","x":"structured_like","cf":"high","why":"Three structured extracellular domain repeats spanning paired cysteine anchors, each conserving an N-terminal C(x){3,5}P[PA]xxφ[SC]W signature and a C-terminal φ[ST]Cxφ motif separated by 40-55 aa flanking beta-strand/linker segments.","i":[[170,215,"CEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQM"],[269,316,"CDAPSNPPAHLSWFQGSPALNATPISNTGILELRRVRSAEEGGFTCRA"],[353,412,"CSFRARPAPSLCWRLEEKPLEGNSSQGSFKVNSSSAGPWANSSLILHGGLSSDLKVSCKA"]]}],"s":"MLPLLLLPLLWGGSLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQMKRQGAQVTTERTVQLNVSYAPQTITIFRNGIALEILQNTSYLPVLEGQALRLLCDAPSNPPAHLSWFQGSPALNATPISNTGILELRRVRSAEEGGFTCRAQHPLGFLQIFLNLSVYSLPQLLGPSCSWEAEGLHCRCSFRARPAPSLCWRLEEKPLEGNSSQGSFKVNSSSAGPWANSSLILHGGLSSDLKVSCKAWNIYGSQSGSVLLLQGRSNLGTGVVPAALGGAGVMALLCICLCLIFFLIVKARRKQAAGRPEKMDDEDPIMGTITSGSRKKPWPDSPGDQASPPGDAPPLEEQKELHYASLSFSEMKSREPKDQEAPSTTEYSEIKTSK"},{"id":"SEQ_06250","a":"Q9Y3S1","g":"WNK2","d":"Serine/threonine-protein kinase WNK2","L":2297,"m":[{"c":"PPQPx[LR]","u":6,"sp":"tandem","x":"disordered_like","cf":"high","why":"Exact 10-copy head-to-tail hexapeptide array in the central proline-rich disordered region anchored by invariant N-terminal PPQP and C-terminal L (9/10) or R (1/10), with an internal dimeric PPQP[TM][LR]-PPQPVL alternation flanked by PPQPAL.","i":[[939,944,"PPQPAL"],[945,950,"PPQPTL"],[951,956,"PPQPVL"],[957,962,"PPQPTL"],[963,968,"PPQPVL"],[969,974,"PPQPTR"],[975,980,"PPQPVL"],[981,986,"PPQPML"],[987,992,"PPQPVL"],[993,998,"PPQPAL"]]},{"c":"φψxFxFDL-x-xPDEψAoxMψExxFφxxx-xxxφφxoψ+Dxψ","u":42,"sp":"dispersed","x":"structured_like","cf":"high","why":"Strongly conserved 42-residue ungapped internal domain duplication (~720 aa apart) sharing 12 identical anchors (FxFDL, PDE, A, M, E, F, D) and 14 physicochemically conserved hydrophobic/charged/polar positions across both the core motif and C-terminal amphipathic helix.","i":[[495,536,"AIEFTFDLEKETPDEVAQEMIESGFFHESDVKIVAKSIRDRV"],[1213,1254,"MVTFKFDLDGDAPDEIATYMVEHDFILQAERETFIEQMKDVM"]]}],"s":"MDGDGGRRDVPGTLMEPGRGAGPAGMAEPRAKAARPGPQRFLRRSVVESDQEEPPGLEAAEAPGPQPPQPLQRRVLLLCKTRRLIAERARGRPAAPAPAALVAQPGAPGAPADAGPEPVGTQEPGPDPIAAAVETAPAPDGGPREEAAATVRKEDEGAAEAKPEPGRTRRDEPEEEEDDEDDLKAVATSLDGRFLKFDIELGRGSFKTVYKGLDTETWVEVAWCELQDRKLTKLERQRFKEEAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTCGIKPASFEKVHDPEIKEIIGECICKNKEERYEIKDLLSHAFFAEDTGVRVELAEEDHGRKSTIALRLWVEDPKKLKGKPKDNGAIEFTFDLEKETPDEVAQEMIESGFFHESDVKIVAKSIRDRVALIQWRRERIWPALQPKEQQDVGSPDKARGPPVPLQVQVTYHAQAGQPGPPEPEEPEADQHLLPPTLPTSATSLASDSTFDSGQGSTVYSDSQSSQQSVMLGSLADAAPSPAQCVCSPPVSEGPVLPQSLPSLGAYQQPTAAPGLPVGSVPAPACPPSLQQHFPDPAMSFAPVLPPPSTPMPTGPGQPAPPGQQPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPPQMPPIPVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPALPLQAVKLPHPPGAPLAMPCRTIVPNAPATIPLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTRPPQPVLPPQPMLPPQPVLPPQPALPVRPEPLQPHLPEQAAPAATPGSQILLGHPAPYAVDVAAQVPTVPVPPAAVLSPPLPEVLLPAAPELLPQFPSSLATVSASVQSVPTQTATLLPPANPPLPGGPGIASPCPTVQLTVEPVQEEQASQDKPPGLPQSCESYGGSDVTSGKELSDSCEGAFGGGRLEGRAARKHHRRSTRARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEHDFILQAERETFIEQMKDVMDKAEDMLSEDTDADRGSDPGTSPPHLSTCGLGTGEESRQSQANAPVYQQNVLHTGKRWFIICPVAEHPAPEAPESSPPLPLSSLPPEASQGPCRGLTLPCLPWRRAACGAVFLSLFSAESAQSKQPPDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAPPAPLAPSSPPVTALPQDGAAPATSTMPEPASGTASQAGGPGTPQGLTSELETSQPLAETHEAPLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQLPSPPLGPTVPPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTLLYQEHVPTSSASAGTPVEVGDRDFTLEPLRGDQPRSEVCGGDLALPPVPKEAVSGRVQLPQPLVEKSELAPTRGAVMEQGTSSSMTAESSPRSMLGYDRDGRQVASDSHVVPSVPQDVPAFVRPARVEPTDRDGGEAGESSAEPPPSDMGTVGGQASHPQTLGARALGSPRKRPEQQDVSSPAKTVGRFSVVSTQDEWTLASPHSLRYSAPPDVYLDEAPSSPDVKLAVRRAQTASSIEVGVGEPVSSDSGDEGPRARPPVQKQASLPVSGSVAGDFVKKATAFLQRPSRAGSLGPETPSRVGMKVPTISVTSFHSQSSYISSDNDSELEDADIKKELQSLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGFFHTAPPTGRRRKTSKSKLKAGKLLNPLVRQLKVVASSTGHLADSSRGPPAKDPAQASVGLTADSTGLSGKAVQTQQPCSVRASLSSDICSGLASDGGGARGQGWTVYHPTSERVTYKSSSKPRARFLSGPVSVSIWSALKRLCLGKEHSSRSSTSSLAPGPEPGPQPALHVQAQVNNSNNKKGTFTDDLHKLVDEWTSKTVGAAQLKPTLNQLKQTQKLQDMEAQAGWAAPGEARAMTAPRAGVGMPRLPPAPGPLSTTVIPGAAPTLSVPTPDGALGTARRNQVWFGLRVPPTACCGHSTQPRGGQRVGSKTASFAASDPVRS"},{"id":"SEQ_06254","a":"Q8IWX8","g":"CHERP","d":"Calcium homeostasis endoplasmic reticulum protein","L":916,"m":[{"c":"W[NG]x[QSG]xxx[PMA]","u":8,"sp":"tandem","x":"disordered_like","cf":"high","why":"Seven head-to-tail tandem 8-aa repeats (0-1 aa gaps) in the central Pro/Gly/Gln-rich disordered region anchored by an invariant N-terminal Trp followed by [NG], predominantly Gln at position 4, and Pro at position 8.","i":[[455,462,"WNNSHEGM"],[463,470,"WGEQRGDP"],[472,479,"WNGQRDAP"],[480,487,"WNNQPDAA"],[488,495,"WNSQFEGP"],[496,503,"WNSQHEQP"],[505,512,"WGGGQREP"]]},{"c":"PP[HRY]xxxxx","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Eleven non-overlapping 8-aa repeats flanking and following the Trp-repeat array in the central disordered region, anchored by a conserved PP[HRY] N-terminal core with multiple exact 8-residue head-to-tail tandem runs.","i":[[440,447,"PPYPHHQG"],[519,526,"PPHFRGPF"],[527,534,"PPHQQHPQ"],[538,545,"PPHPHNFN"],[548,555,"PPRFMQDD"],[557,564,"PPRHPFER"],[565,572,"PPYPHRFD"],[584,591,"PPHHHPGH"],[615,622,"PPHGFNGQ"],[623,630,"PPHMRRQG"],[631,638,"PPHINHDD"]]}],"s":"MEMPLPPDDQELRNVIDKLAQFVARNGPEFEKMTMEKQKDNPKFSFLFGGEFYSYYKCKLALEQQQLICKQQTPELEPAATMPPLPQPPLAPAAPIPPAQGAPSMDELIQQSQWNLQQQEQHLLALRQEQVTAAVAHAVEQQMQKLLEETQLDMNEFDNLLQPIIDTCTKDAISAGKNWMFSNAKSPPHCELMAGHLRNRITADGAHFELRLHLIYLINDVLHHCQRKQARELLAALQKVVVPIYCTSFLAVEEDKQQKIARLLQLWEKNGYFDDSIIQQLQSPALGLGQYQATLINEYSSVVQPVQLAFQQQIQTLKTQHEEFVTSLAQQQQQQQQQQQQLQMPQMEAEVKATPPPPAPPPAPAPAPAIPPTTQPDDSKPPIQMPGSSEYEAPGGVQDPAAAGPRGPGPHDQIPPNKPPWFDQPHPVAPWGQQQPPEQPPYPHHQGGPPHCPPWNNSHEGMWGEQRGDPGWNGQRDAPWNNQPDAAWNSQFEGPWNSQHEQPPWGGGQREPPFRMQRPPHFRGPFPPHQQHPQFNQPPHPHNFNRFPPRFMQDDFPPRHPFERPPYPHRFDYPQGDFPAEMGPPHHHPGHRMPHPGINEHPPWAGPQHPDFGPPPHGFNGQPPHMRRQGPPHINHDDPSLVPNVPYFDLPAGLMAPLVKLEDHEYKPLDPKDIRLPPPMPPSERLLAAVEAFYSPPSHDRPRNSEGWEQNGLYEFFRAKMRARRRKGQEKRNSGPSRSRSRSKSRGRSSSRSNSRSSKSSGSYSRSRSRSCSRSYSRSRSRSRSRSRSSRSRSRSQSRSRSKSYSPGRRRRSRSRSPTPPSSAGLGSNSAPPIPDSRLGEENKGHQMLVKMGWSGSGGLGAKEQGIQDPIKGGDVRDKWDQYKGVGVALDDPYENYRRNKSYSFIARMKARDECK"},{"id":"SEQ_06257","a":"Q4KMQ1","g":"TPRN","d":"Taperin","L":711,"m":[{"c":"L[QR]xx[GS][SR]N[ST]F[TM]VxP+","u":14,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 14-aa motif copies across proline/polar-rich disordered segments sharing five invariant anchors (L, N, F, V, P) and six tightly constrained positions ([QR], [GS], [SR], [ST], [TM], and basic C-terminal K/R).","i":[[197,210,"LQKTGSNSFTVHPR"],[323,336,"LRANSRNSFMVIPK"],[493,506,"LQPRGSNTFTVVPK"]]}],"s":"MAALGRPGSGPRAAVPAWKREILERKRAKLAALGGGAGPGAAEPEQRVLAESLGPLRENPFMLLEAERRRGGGAAGARLLERYRRVPGVRALRADSVLIIETVPGFPPAPPAPGAAQIRAAEVLVYGAPPGRVSRLLERFDPPAAPRRRGSPERARPPPPPPPPAPPRPPPAAPSPPAAPGPRGGGASPGARRSDFLQKTGSNSFTVHPRGLHRGAGARLLSNGHSAPEPRAGPANRLAGSPPGSGQWKPKVESGDPSLHPPPSPGTPSATPASPPASATPSQRQCVSAATSTNDSFEIRPAPKPVMETIPLGDLQARALASLRANSRNSFMVIPKSKASGAPPPEGRQSVELPKGDLGPASPSQELGSQPVPGGDGAPALGKSPLEVEAQWAVEEGACPRTATALADRAIRWQRPSSPPPFLPAASEEAEPAEGLRVPGLAKNSREYVRPGLPVTFIDEVDSEEAPQAAKLPYLPHPARPLHPARPGCVAELQPRGSNTFTVVPKRKPGTLQDQHFSQANREPRPREAEEEEASCLLGPTLKKRYPTVHEIEVIGGYLALQKSCLTKAGSSRKKMKISFNDKSLQTTFEYPSESSLEQEEEVDQQEEEEEEEEEEEEEEEGSGSEEKPFALFLPRATFVSSVRPESSRLPEGSSGLSSYTPKHSVAFSKWQEQALEQAPREAEPPPVEAMLTPASQNDLSDFRSEPALYF"},{"id":"SEQ_06259","a":"Q9HCD5","g":"NCOA5","d":"Nuclear receptor coactivator 5","L":579,"m":[{"c":"[YF]DRY[RL][DR]","u":6,"sp":"periodic","x":"disordered_like","cf":"medium","why":"Three regularly spaced 6-aa repeats (~13-14 aa linkers) in the N-terminal disordered region anchored by an aromatic-Asp-Arg-Tyr ([YF]DRY) core followed by [RL][DR].","i":[[107,112,"YDRYRD"],[127,132,"YDRYLR"],[145,150,"FDRYRD"]]}],"s":"MNTAPSRPSPTRRDPYGFGDSRDSRRDRSPIRGSPRREPRDGRNGRDARDSRDIRDPRDLRDHRHSRDLRDHRDSRSVRDVRDVRDLRDFRDLRDSRDFRDQRDPMYDRYRDMRDSRDPMYRREGSYDRYLRMDDYCRRKDDSYFDRYRDSFDGRGPPGPESQSRAKERLKREERRREELYRQYFEEIQRRFDAERPVDCSVIVVNKQTKDYAESVGRKVRDLGMVVDLIFLNTEVSLSQALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQEHRNMPQADAMVLVARNYERYKNECREKEREEIARQAAKMADEAILQERERGGPEEGVRGGHPPAIQSLINLLADNRYLTAEETDKIINYLRERKERLMRSSTDSLPGPISRQPLGATSGASLKTQPSSQPLQSGQVLPSATPTPSAPPTSQQELQAKILSLFNSGTVTANSSSASPSVAAGNTPNQNFSTAANSQPQQRSQASGNQPPSILGQGGSAQNMGPRPGAPSQGLFGQPSSRLAPASNMTSQRPVSSTGINFDNPSVQKALDTLIQSGPALSHLVSQTTAQMGQPQAPMGSYQRHY"},{"id":"SEQ_06281","a":"O75363","g":"BCAS1","d":"Breast carcinoma-amplified sequence 1","L":584,"m":[{"c":"SψxxF[FL]+xψ","u":9,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 9-aa amphipathic motifs embedded within an aromatic-depleted disordered sequence share fixed N-terminal S and central F anchors, a [FL]+ core, and large aliphatic (ψ) flanks at positions 2 and 9 (with related gapped/divergent FF/FW islands elsewhere in the chain).","i":[[286,294,"SIMSFFKTL"],[442,450,"SLMAFLRQM"],[552,560,"SLGGFFKGL"]]}],"s":"MGNQMSVPQRVEDQENEPEAETYQDNASALNGVPVVVSTHTVQHLEEVDLGISVKTDNVATSSPETTEISAVADANGKNLGKEAKPEAPAAKSRFFLMLSRPVPGRTGDQAADSSLGSVKLDVSSNKAPANKDPSESWTLPVAAGPGQDTDKTPGHAPAQDKVLSAARDPTLLPPETGGAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIVDGKEKEGQELGTADCSVPGDPEGLETAKDDSQAAAIAENNNSIMSFFKTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKREESKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSDSTEKTITPPEPEPTGAPQKGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQNGDKLQKRPEKRQQSLGGFFKGLGPKRMLDAQVQTDPVSIGPVGKSK"},{"id":"SEQ_06291","a":"O75122","g":"CLASP2","d":"CLIP-associating protein 2","L":1294,"m":[{"c":"φS[AV]x+[RS]S+IPR(x){0,3}SQGCSREAS","u":"20-23","sp":"tandem","x":"disordered_like","cf":"high","why":"Strongly conserved 2-copy tandem duplication in the central S/R/P-rich disordered region sharing 14 identical positions—including invariant IPR and SQGCSREAS blocks—plus conserved basic (+) and hydrophobic (φ/[AV]) positions across a 3-residue internal indel.","i":[[488,507,"ASAQKRSKIPRSQGCSREAS"],[511,533,"LSVARSSRIPRPSVSQGCSREAS"]]}],"s":"MAMGDDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGGASKEGGAGAVDEDDFIKAFTDVPSIQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSAKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESLNRPFSSKWSTANPSTVAGRVSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQSVRSGRLGAGALNAGSYASLEDTSDKLDGTASEDGRVRAKLSAPLAGMGNAKADSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASAQKRSKIPRSQGCSREASPSRLSVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLASRHHSRSTGALYAPEVYGASGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALKKPARRRYESYGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADPHGKRVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIGDELKPHLSQLTGSKMKLLNLYIKRAQTGSGGADPTTDVSGQS"},{"id":"SEQ_06300","a":"Q9P2E9","g":"RRBP1","d":"Ribosome-binding protein 1","L":1410,"m":[{"c":"G+K[AV]-G[ATS][QP]NQ","u":10,"sp":"tandem","x":"disordered_like","cf":"high","why":"Extensive tandem array of 40 highly conserved decapeptide repeats (predominantly GKKAEGAQNQ and GKKAEGTPNQ, interrupted once by an 8-aa C-terminally truncated unit GKKTEGAQ) in a polar/charged disordered region preceding the long C-terminal coiled-coil rod.","i":[[199,208,"GKKAEGTQNQ"],[209,218,"SKKAEGAPNQ"],[219,228,"GRKAEGTPNQ"],[229,238,"GKKTEGTPNQ"],[239,248,"GKKAEGTPNQ"],[249,258,"GKKAEGTPNQ"],[259,268,"GKKAEGAQNQ"],[269,278,"GKKVDTTPNQ"],[279,288,"GKKVEGAPTQ"],[289,298,"GRKAEGAQNQ"],[299,308,"AKKVEGAQNQ"],[309,318,"GKKAEGAQNQ"],[319,328,"GKKGEGAQNQ"],[329,338,"GKKAEGAQNQ"],[339,348,"GKKAEGAQNQ"],[349,358,"GKKAEGAQNQ"],[359,368,"GKKAEGAQNQ"],[369,378,"GKKAEGAQNQ"],[379,388,"GKKAEGAQNQ"],[389,398,"GKKVEGAQNQ"],[399,408,"GKKAEGAQNQ"],[409,418,"GKKAEGAQNQ"],[419,428,"GKKAEGAQNQ"],[429,438,"GKKAEGAQNQ"],[439,448,"GKKAEGAQNQ"],[449,458,"GKKAEGAQNQ"],[459,468,"GKKAEGAQNQ"],[469,478,"GKKVEGAQNQ"],[479,488,"GKKAEGAQNQ"],[489,498,"GKKAEGAQNQ"],[499,508,"GKKAEGAQNQ"],[509,518,"GQKGEGAQNQ"],[527,536,"GKKAERSPNQ"],[537,546,"GKKGEGAPIQ"],[547,556,"GKKADSVANQ"],[557,566,"GTKVEGITNQ"],[567,576,"GKKAEGSPSE"],[577,586,"GKKAEGSPNQ"],[587,596,"GKKADAAANQ"],[597,606,"GKKTESASVQ"]]}],"s":"MDIYDTQTLGVVVFGGFMVVSAIGIFLVSTFSMKETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEVPMVVVPPVGAKGNTPATGTTQGKKAEGTQNQSKKAEGAPNQGRKAEGTPNQGKKTEGTPNQGKKAEGTPNQGKKAEGTPNQGKKAEGAQNQGKKVDTTPNQGKKVEGAPTQGRKAEGAQNQAKKVEGAQNQGKKAEGAQNQGKKGEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKVEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKVEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGQKGEGAQNQGKKTEGAQGKKAERSPNQGKKGEGAPIQGKKADSVANQGTKVEGITNQGKKAEGSPSEGKKAEGSPNQGKKADAAANQGKKTESASVQGRNTDVAQSPEAPKQEAPAKKKSGSKKKGEPGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLLSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAEDGSSSKEGTSV"},{"id":"SEQ_06302","a":"Q86VR7","g":"VSIG10L","d":"V-set and immunoglobulin domain-containing protein 10-like","L":867,"m":[{"c":"xxxP(x){20,26}C(x){7,12}[WF](x){28,39}φxC(x){14,19}","u":"85-99","sp":"tandem","x":"structured_like","cf":"high","why":"Four head-to-tail tandem structured domain repeats (~85-99 aa) anchored by an N-terminal proline at position 4, an invariant cysteine pair, a conserved core aromatic residue (W/F) 7-12 aa after the first cysteine, and a hydrophobic-x-C motif near the C-terminus.","i":[[299,397,"EPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFY"],[398,490,"GPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTV"],[491,575,"ADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLAAVPAHPRLSGVPITCLARHLVATRTCTVT"],[576,669,"PEAPREVLLHPLVAETRLGEAEVALEASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALGAGGDQITLI"]]},{"c":"KLSφ[EQ][AS]P-SKFS[PA]-xx","u":16,"sp":"tandem","x":"disordered_like","cf":"medium","why":"High-conservation 16-aa tandem duplication (separated by a 2-aa DL linker) in the N-terminal Ser/Pro-rich disordered region sharing eight identical anchor positions (KLS, P, SKFS) and three conserved hydrophobic/acidic positions.","i":[[153,168,"KLSVEAPDSKFSPDDM"],[171,186,"KLSAQSPESKFSAETH"]]}],"s":"MDNPQALPLFLLLASLVGILTLRASSGLQQTNFSSAFSSDSKSSSQGLGVEVPSIKPPSWKVPDQFLDSKASAGISDSSWFPEALSSNMSGSFWSNVSAEGQDLSPVSPFSETPGSEVFPDISDPQVPAKDPKPSFTVKTPASNISTQVSHTKLSVEAPDSKFSPDDMDLKLSAQSPESKFSAETHSAASFPQQVGGPLAVLVGTTIRLPLVPIPNPGPPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGVYTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGELSWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAADVSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSLADPAEAAVPAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPGAPQCSVEGGPGDRSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLAAVPAHPRLSGVPITCLARHLVATRTCTVTPEAPREVLLHPLVAETRLGEAEVALEASGCPPPSRASWAREGRPLAPGGGSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALGAGGDQITLIGPSISSWRLQRARDAAVLTWDVERGALISSFEIQAWPDGPALGRTSTYRDWVSLLILGPQERSAVVPLPPRNPGTWTFRILPILGGQPGTPSQSRVYRAGPTLSHGAIAGIVLGSLLGLALLAVLLLLCICCLCRFRGKTPEKKKHPSTLVPVVTPSEKKMHSVTPVEISWPLDLKVPLEDHSSTRAYQAQTPVQLSL"},{"id":"SEQ_06309","a":"Q8TF50","g":"ZNF526","d":"Zinc finger protein 526","L":670,"m":[{"c":"xxC(x){1,2}CxxxxxxxxxxxxH(x){3,4}H","u":"22-24","sp":"dispersed","x":"structured_like","cf":"high","why":"Fourteen C2H2-type zinc-finger repeats sharing invariant Cys2/His2 coordinating anchors separated by a fixed 12-residue core and mostly aromatic/histidine N-terminal positions, arranged in periodic 5-aa-linked clusters separated by longer proline/acidic linkers.","i":[[57,79,"FMCSECGSLYNTLEEVLSHQEQH"],[108,130,"FQCGECSQLILSPGELLAHQDAH"],[140,163,"YQCWDCQELFPSPELWVAHRKAQH"],[197,219,"YECPECSTLCATPEEFLEHQGTH"],[273,296,"QGCGDCPQHQPSAGARRQHRRTAH"],[305,327,"FHCSQCQRSFSSANRLQAHGRAH"],[332,354,"HECTTCSKVFKKAASLEQHLRLH"],[360,382,"YLCVDCGRGFGTELTLVAHRRAH"],[388,409,"HRCRCGKTFSNMTKFLYHRRTH"],[442,465,"LPCPQCSKSFASASRLSRHRRAVH"],[472,494,"HRCGVCGKGFKKLIHVRNHLRTH"],[500,522,"FQCHSCGKTFASLANLSRHQLTH"],[528,550,"YQCLDCGKRFTQSSNLQQHRRLH"],[573,595,"YYCGTCGRWFRAMAGLRLHQRVH"]]},{"c":"[EG]φxEM[PST][TP]","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Four short repeats in the disordered N-terminal tail anchored by an invariant EM dipeptide, a preceding hydrophobic residue, and a C-terminal Ser/Thr/Pro phosphorylation-like dipeptide.","i":[[7,13,"EVAEMPT"],[18,24,"GAVEMST"],[29,35,"EMMEMST"],[36,42,"EVTEMTP"]]}],"s":"MAEVVAEVAEMPTQMSPGAVEMSTPMSAEMMEMSTEVTEMTPGEALASSLFFQHHQFMCSECGSLYNTLEEVLSHQEQHMLAVSEEEALTTQNVGLEPELVPGAEGPFQCGECSQLILSPGELLAHQDAHLRESANQIQYQCWDCQELFPSPELWVAHRKAQHLSATVAEPPVPPPLPPPTPLPPPSPPSEVKMEPYECPECSTLCATPEEFLEHQGTHFDSLEKEERNGLEEEEEDDEEDEEDDEEMEDEEAMAEVGDDAVGGDESTAGWAQGCGDCPQHQPSAGARRQHRRTAHSPASATHPFHCSQCQRSFSSANRLQAHGRAHVGGTHECTTCSKVFKKAASLEQHLRLHRGEARYLCVDCGRGFGTELTLVAHRRAHTANPLHRCRCGKTFSNMTKFLYHRRTHAGKSGAPPTGATAPPAPAEPTPPPPPPAPPAQLPCPQCSKSFASASRLSRHRRAVHGPPERRHRCGVCGKGFKKLIHVRNHLRTHTGERPFQCHSCGKTFASLANLSRHQLTHTGARPYQCLDCGKRFTQSSNLQQHRRLHLRPVAFARAPRLPITGLYNKSPYYCGTCGRWFRAMAGLRLHQRVHARARTLTLQPPRSPSPAPPPPPEPQQTIMCTELGETIAIIETSQPLALEDTLQLCQAALGASEAGGLLQLDTAFV"},{"id":"SEQ_06318","a":"Q13585","g":"GPR50","d":"Melatonin-related receptor","L":617,"m":[{"c":"xxxx[HYN]xK","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Seventeen 7-residue repeats in the C-terminal disordered tail (including an unbroken 11-copy head-to-tail core array from residues 399-475) strongly anchored by a conserved His (rarely Tyr/Asn) at position 5, an invariant Lys at position 7, and frequent Pro/Ser/Ala/Thr enrichment at positions 1-3 and 6.","i":[[381,387,"RASGHPK"],[399,405,"SASTHHK"],[406,412,"SVFSHSK"],[413,419,"AASGHLK"],[420,426,"PVSGHSK"],[427,433,"PASGHPK"],[434,440,"SATVYPK"],[441,447,"PASVHFK"],[448,454,"ADSVHFK"],[455,461,"GDSVHFK"],[462,468,"PDSVHFK"],[469,475,"PASSNPK"],[483,489,"SAGSHSK"],[494,500,"AATSHPK"],[501,507,"PTTGHIK"],[516,522,"TTADYPK"],[524,530,"ATTSHPK"]]}],"s":"MGPTLAVPTPYGCIGCKLPQPEYPPALIIFMFCAMVITIVVDLIGNSMVILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGTIEYDPRTYTCIFNYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARDPAGQNPDNQLAEVRNFLTMFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHACPAVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRKSASTHHKSVFSHSKAASGHLKPVSGHSKPASGHPKSATVYPKPASVHFKADSVHFKGDSVHFKPDSVHFKPASSNPKPITGHHVSAGSHSKSAFSAATSHPKPTTGHIKPATSHAEPTTADYPKPATTSHPKPTAADNPELSASHCPEIPAIAHPVSDDSDLPESASSPAAGPTKPAASQLESDTIADLPDPTVVTTSTNDYHDVVVIDVEDDPDEMAV"},{"id":"SEQ_06325","a":"Q6VEQ5","g":"WASH2P","d":"WAS protein family homolog 2","L":465,"m":[{"c":"Yψ[PA]DL[GP]","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three clustered copies in an IDR linker (residues 234-267) sharing invariant Y, D, and L anchors, a conserved large aliphatic position (V/L/I), and constrained [PA] and [GP] choices separated by 7-9 aa linkers.","i":[[234,239,"YVPDLG"],[249,254,"YLPDLP"],[262,267,"YIADLG"]]}],"s":"MTPVRMQHSLAGQTYAVPLIQPDLRREEAVQQMADALQYLQKVSGDIFSRISQQVEQSRSQVQAIGEKVSLAQAKIEKIKGSKKAIKVFSSAKYPAPERLQEYGSIFTGAQDPGLQRRPRHRIQSKHRPLDERALQEKLKDFPVCVSTKPEPEDDAEEGLGGLPSNISSVSSLLLFNTTENLYKKYVFLDPLAGAVTKTHVMLGAETEEKLFDAPLSISKREQLEQQVPENYFYVPDLGQVPEIDVPSYLPDLPGIANDLMYIADLGPGIAPSAPGTIPELPTFHTEVAEPLKVDLQDGVLTPPPPPPPPPPAPEVLASAPPLPPSTAAPVGQGARQDDSSSSASPSVQGAPREVVDPSGGRATLLESIRQAGGIGKAKLRSMKERKLEKKKQKEQEQVRATSQGGHLMSDLFNKLVMRRKGISGKGPGAGEGPGGAFARVSDSIPPLPPPQQPQAEEDEDDWES"},{"id":"SEQ_06335","a":"Q96RF0","g":"SNX18","d":"Sorting nexin-18","L":628,"m":[{"c":"[PVA]PPxxF[QEK]","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four non-overlapping copies in a proline-rich disordered region (residues 81-120) anchored by invariant PP and F residues at fixed spacing, flanked by conserved N-terminal [PVA] and C-terminal polar/charged [QEK] positions.","i":[[81,87,"VPPGGFE"],[92,98,"APPASFK"],[99,105,"PPPDAFQ"],[114,120,"PPPSTFQ"]]}],"s":"MALRARALYDFRSENPGEISLREHEVLSLCSEQDIEGWLEGVNSRGDRGLFPASYVQVIRAPEPGPAGDGGPGAPARYANVPPGGFEPLPVAPPASFKPPPDAFQALLQPQQAPPPSTFQPPGAGFPYGGGALQPSPQQLYGGYQASQGSDDDWDDEWDDSSTVADEPGALGSGAYPDLDGSSSAGVGAAGRYRLSTRSDLSLGSRGGSVPPQHHPSGPKSSATVSRNLNRFSTFVKSGGEAFVLGEASGFVKDGDKLCVVLGPYGPEWQENPYPFQCTIDDPTKQTKFKGMKSYISYKLVPTHTQVPVHRRYKHFDWLYARLAEKFPVISVPHLPEKQATGRFEEDFISKRRKGLIWWMNHMASHPVLAQCDVFQHFLTCPSSTDEKAWKQGKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESKIDGFKCFTKKMDDSALQLNHTANEFARKQVTGFKKEYQKVGQSFRGLSQAFELDQQAFSVGLNQAIAFTGDAYDAIGELFAEQPRQDLDPVMDLLALYQGHLANFPDIIHVQKGKAWPLEQVIWSVLCRLKGATLTAVPLWVSESYSTGEEASRDVDAWVFSLECKLDCSTGSFLLEYLALGNEYSFSKVQRVPLMTVLSF"},{"id":"SEQ_06337","a":"Q5VWX1","g":"KHDRBS2","d":"KH domain-containing, RNA-binding, signal transduction-associated protein 2","L":349,"m":[{"c":"RG[VA][LP][TP][PV][RP]","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four closely spaced 7-aa repeats in the C-terminal disordered region (residues 218-254) with invariant N-terminal RG anchors and strict two-residue choices at all five remaining positions, organized as an internal duplication of paired RGV[LP]TPR and RGA[LP][PT]VP units.","i":[[218,224,"RGVLTPR"],[230,236,"RGALPVP"],[240,246,"RGVPTPR"],[248,254,"RGAPTVP"]]}],"s":"MEEEKYLPELMAEKDSLDPSFVHASRLLAEEIEKFQGSDGKKEDEEKKYLDVISNKNIKLSERVLIPVKQYPKFNFVGKLLGPRGNSLKRLQEETGAKMSILGKGSMRDKAKEEELRKSGEAKYAHLSDELHVLIEVFAPPGEAYSRMSHALEEIKKFLVPDYNDEIRQEQLRELSYLNGSEDSGRGRGIRGRGIRIAPTAPSRGRGGAIPPPPPPGRGVLTPRGSTVTRGALPVPPVARGVPTPRARGAPTVPGYRAPPPPAHEAYEEYGYDDGYGGEYDDQTYETYDNSYATQTQSVPEYYDYGHGVSEDAYDSYAPEEWATTRSSLKAPPQRSARGGYREHPYGRY"},{"id":"SEQ_06340","a":"Q9Y2Y9","g":"KLF13","d":"Krueppel-like factor 13","L":288,"m":[{"c":"+[KP][FH]xC(x){2,4}C[EN]KxΩx+S[DS][EH]LxxHφR[RT]H[AT]","u":"26-28","sp":"tandem","x":"structured_like","cf":"high","why":"Three tandem 26-28 aa repeats separated by 2-residue GE linkers, anchored by paired cysteines C(x){2,4}C, conserved aromatic/basic/leucine core positions (KxΩx+S[DS][EH]L), and a C-terminal HφR[RT]H[AT] histidine pair.","i":[[165,192,"RKHKCHYAGCEKVYGKSSHLKAHLRTHT"],[195,222,"RPFACSWQDCNKKFARSDELARHYRTHT"],[225,250,"KKFSCPICEKRFMRSDHLTKHARRHA"]]}],"s":"MAAAAYVDHFAAECLVSMSSRAVVHGPREGPESRPEGAAVAATPTLPRVEERRDGKDSASLFVVARILADLNQQAPAPAPAERREGAAARKARTPCRLPPPAPEPTSPGAEGAAAAPPSPAWSEPEPEAGLEPEREPGPAGSGEPGLRQRVRRGRSRADLESPQRKHKCHYAGCEKVYGKSSHLKAHLRTHTGERPFACSWQDCNKKFARSDELARHYRTHTGEKKFSCPICEKRFMRSDHLTKHARRHANFHPGMLQRRGGGSRTGSLSDYSRSDASSPTISPASSP"},{"id":"SEQ_06354","a":"P58397","g":"ADAMTS12","d":"A disintegrin and metalloproteinase with thrombospondin motifs 12","L":1594,"m":[{"c":"W(x){4,5}WxxCSxoC[GS](x){1,2}GxxxxxxxC(x){4,15}C(x){9,13}C(x){4,5}C","u":"46-59","sp":"dispersed","x":"structured_like","cf":"high","why":"Eight 46-59 aa cysteine- and tryptophan-rich domain repeats anchored by an N-terminal W(x){4,5}W motif, an invariant CSxoC[GS](x){1,2}G core, and four conserved downstream cysteines ending in a C(x){4,5}C pair; arranged as one isolated copy plus two local tandem arrays (3 and 4 copies with 2-3 aa linkers) separated by long intervening regions.","i":[[545,596,"WGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPC"],[828,882,"WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKAC"],[886,944,"WWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILC"],[948,996,"WTVGNWSECSVSCGGGVRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQC"],[1317,1365,"WIVGNWSECSTTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKRCHLRPC"],[1368,1424,"WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPC"],[1427,1472,"WQVEPWSQCSRSCGGGVQERGVFCPGGLCDWTKRPTSTMSCNEHLC"],[1475,1531,"WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC"]]}],"s":"MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDWVYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVKKHPLVEGGYHPHIVYRRQKVPETKEPTCGLKDSVNISQKQELWREKWERHNLPSRSLSRRSISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVENVCQTLWCSVKGFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYKNELYHWFPIFNPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDLEKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQCPSSRRVLKPNKGTISNGKNPPTLKPVPPPTSRPRMLTTPTGPESMSTSTPAISSPSPTTASKEGDLGGKQWQDSSTQPELSSRYLISTGSTSQPILTSQSLSIQPSEENVSSSDTGPTSEGGLVATTTSGSGLSSSRNPITWPVTPFYNTLTKGPEMEIHSGSGEEREQPEDKDESNPVIWTKIRVPGNDAPVESTEMPLAPPLTPDLSRESWWPPFSTVMEGLLPSQRPTTSETGTPRVEGMVTEKPANTLLPLGGDHQPEPSGKTANRNHLKLPNNMNQTKSSEPVLTEEDATSLITEGFLLNASNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGLCDWTKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSCPQTHITHTQRQRRQRLLQKSKEL"},{"id":"SEQ_06361","a":"Q13439","g":"GOLGA4","d":"Golgin subfamily A member 4","L":2230,"m":[{"c":"Rx[PS]xxESLx","u":9,"sp":"tandem","x":"disordered_like","cf":"high","why":"Four head-to-tail tandem 9-aa repeats in the N-terminal disordered tail (residues 68-103) anchored by invariant R1, E6, S7, and L8 positions plus a constrained [PS]3 position, located upstream of an extended ~1980-aa coiled-coil heptad region.","i":[[68,76,"RVPSVESLF"],[77,85,"RSPIKESLF"],[86,94,"RSSSKESLV"],[95,103,"RTSSRESLN"]]}],"s":"MFKKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGGNLYHTDVSLFGEPTEFEYLRKVLFEYMMGRETKTMAKVITTVLKFPDDQTQKILEREDARLMFTSPRSGIF"},{"id":"SEQ_06371","a":"P32519","g":"ELF1","d":"ETS-related transcription factor Elf-1","L":619,"m":[{"c":"SP[RY]xoQL","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed copies of a 7-residue motif in the C-terminal polar/proline-rich disordered region anchored by invariant N-terminal SP and C-terminal QL dipeptides, a conserved polar residue at position 5, and R/Y at position 3.","i":[[376,382,"SPYPTQL"],[432,438,"SPRNQQL"],[538,544,"SPRSSQL"]]}],"s":"MAAVVQQNDLVFEFASNVMEDERQLGDPAIFPAVIVEHVPGADILNSYAGLACVEEPNDMITESSLDVAEEEIIDDDDDDITLTVEASCHDGDETIETIEAAEALLNMDSPGPMLDEKRINNNIFSSPEDDMVVAPVTHVSVTLDGIPEVMETQQVQEKYADSPGASSPEQPKRKKGRKTKPPRPDSPATTPNISVKKKNKDGKGNTIYLWEFLLALLQDKATCPKYIKWTQREKGIFKLVDSKAVSRLWGKHKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKEMPKDLIYINDEDPSSSIESSDPSLSSSATSNRNQTSRSRVSSSPGVKGGATTVLKPGNSKAAKPKDPVEVAQPSEVLRTVQPTQSPYPTQLFRTVHVVQPVQAVPEGEAARTSTMQDETLNSSVQSIRTIQAPTQVPVVVSPRNQQLHTVTLQTVPLTTVIASTDPSAGTGSQKFILQAIPSSQPMTVLKENVMLQSQKAGSPPSIVLGPAQVQQVLTSNVQTICNGTVSVASSPSFSATAPVVTFSPRSSQLVAHPPGTVITSVIKTQETKTLTQEVEKKESEDHLKENTEKTEQQPQPYVMVVSSSNGFTSQVAMKQNELLEPNSF"},{"id":"SEQ_06374","a":"Q15464","g":"SHB","d":"SH2 domain-containing adapter protein B","L":509,"m":[{"c":"YxxPΩ-","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed 6-residue copies in the central disordered region share invariant Y1 and P4 anchors followed by a conserved aromatic position (F/Y/W) and C-terminal acidic residue (D/E), with each spacer also containing an acidic residue.","i":[[246,251,"YSDPFD"],[268,273,"YMEPYE"],[297,302,"YDTPYE"],[336,341,"YDQPWE"]]}],"s":"MAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSGSLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGSPHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSDPFDAKNDLKSKAGKGESAGYMEPYEAQRIMTEFQRQESVRSQHKGIQLYDTPYEPEGQSVDSDSESTVSPRLRESKLPQDDDRPADEYDQPWEWNRVTIPALAAQFNGNEKRQSSPSPSRDRRRQLRAPGGGFKPIKHGSPEFCGILGERVDPAVPLEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEKYVLGQNSPPFDSVPEVIHYYTTRKLPIKGAEHLSLLYPVAVRTL"},{"id":"SEQ_06378","a":"Q6N043","g":"ZNF280D","d":"Zinc finger protein 280D","L":979,"m":[{"c":"CxxC(x){9,14}H(x){3,5}[HC]","u":"20-23","sp":"dispersed","x":"structured_like","cf":"high","why":"Ten C2H2-type zinc-coordinating domain repeats arranged in two clusters and an N-terminal outlier share invariant CxxC and H(x){3,5}[HC] chelating anchors flanking a hydrophobic-bearing core loop (predominantly 12 residues, ranging 9-14).","i":[[242,262,"CPKCNIHFNLLDPLKNHMKYC"],[323,343,"CFSCLKILKNNIRFMNHMKHH"],[360,381,"CQHCYRQFPTPFQLQCHIESTH"],[390,411,"CKICELSFETEHVLLQHMKDNH"],[420,441,"CQVCNYRSSSFSDVETHFRTSH"],[449,469,"CPFCLKVIKIATPYMHHYMKH"],[477,498,"CTKCRLQFLTCKEKMDHKTQHH"],[626,645,"CIECCSEIKDFANHFPTYVH"],[646,667,"CSFCRYNTSCSKAYVNHMMSFH"],[692,714,"CLNCDFLSDVSGLDNMATHLSQH"]]},{"c":"K[PS]Nx[SV]","u":5,"sp":"tandem","x":"disordered_like","cf":"high","why":"Five contiguous head-to-tail 5-residue repeats in the central disordered linker are anchored by invariant K1 and N3 positions, a constrained P/S choice at position 2, and S/V at position 5.","i":[[559,563,"KSNTS"],[564,568,"KPNTV"],[569,573,"KSNAS"],[574,578,"KPNTS"],[579,583,"KPNGS"]]}],"s":"MGDNPFQPKSNSKMAELFMECEEEELEPWQKKVKEVEDDDDDEPIFVGEISSSKPAISNILNRVNPSSYSRGLKNGALSRGITAAFKPTSQHYTNPTSNPVPASPINFHPESRSSDSSVIVQPFSKPGYITNSSRVVSNKSSELLFDLTQDTGLSHYQGGPTLSMAGMSESSFLSKRPSTSEVNNVNPKKPKPSESVSGANSSAVLPSVKSPSVTSSQAMLAKGTNTSSNQSKNGTPFPRACPKCNIHFNLLDPLKNHMKYCCPDMINNFLGLAKTEFSSTVNKNTTIDSEKGKLIMLVNDFYYGKHEGDVQEEQKTHTTFKCFSCLKILKNNIRFMNHMKHHLELEKQSSESWENHTTCQHCYRQFPTPFQLQCHIESTHTPHEFSTICKICELSFETEHVLLQHMKDNHKPGEMPYVCQVCNYRSSSFSDVETHFRTSHENTKNLLCPFCLKVIKIATPYMHHYMKHQKKGIHRCTKCRLQFLTCKEKMDHKTQHHRTFIKPKQLEGLPPGTKVTIRASVGPLQSGASPTPSISASASTLQLSPPRTKNITAKNPAKSNTSKPNTVKSNASKPNTSKPNGSKSKYKPKISNMQKKQSTLASSNKKSKVNTALRNLRYRRGIHKCIECCSEIKDFANHFPTYVHCSFCRYNTSCSKAYVNHMMSFHSNRPSKRFCIFKKHSENLRGITLVCLNCDFLSDVSGLDNMATHLSQHKTHTCQVVMQKVSVCIPTSEHLSELKKEAPAKEQEPVSKEIARPNMAERETETSNSESKQDKAASSKEKNGCNANSFEGSSTTKSEESITVSDKENETCLADQETGSKNIVSCDSNIGADKVEKKKQIQHVCQEMELKMCQSSENIILSDQIKDHNSSEARFSSKNIKDLRLASDNVSIDQFLRKRHEPESVSSDVSEQGSIHLEPLTPSEVLEYEATEILQKGSGDPSAKTDEVVSDQTDDIPGGNNPSTTEATVDLEDEKERS"},{"id":"SEQ_06386","a":"O60315","g":"ZEB2","d":"Zinc finger E-box-binding homeobox 2","L":1214,"m":[{"c":"CxxCxxx[FY]xxxxx[LY]xxH(x){3,7}[HC]","u":"21-25","sp":"dispersed","x":"structured_like","cf":"high","why":"Eight dispersed/clustered 21-25 aa Cys2-His2/Cys repeats organized in three regions (4 N-terminal, 1 central, 3 C-terminal, including a highly conserved tandem two-unit internal duplication), anchored by invariant CxxC, an aromatic [FY] at +7, [LY] at +13, invariant H at +16, and a C-terminal [HC].","i":[[213,234,"CPYCDRGYKRLTSLKEHIKYRH"],[243,263,"CPLCSYTFAYRTQLERHMVTH"],[284,304,"CTECGKAFKYKHHLKEHLRIH"],[312,334,"CPNCKKRFSHSGSYSSHISSKKC"],[583,604,"CQFCKESFPGPIPLHQHERYLC"],[1001,1021,"CDLCDKTFQKSSSLLRHKYEH"],[1029,1049,"CQICKKAFKHKHHLIEHSRLH"],[1057,1081,"CDKCGKRFSHSGSYSQHMNHRYSYC"]]},{"c":"[ES]PL[DN][LF][NST]","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed hexapeptide motifs within the long central disordered linkers, tightly anchored by a fixed PL core, acidic/polar [ES] cap, [DN] at position 4, hydrophobic [LF] at position 5, and polar [NST] at position 6.","i":[[393,398,"EPLDFN"],[784,789,"SPLNLS"],[814,819,"EPLDLS"],[858,863,"EPLNLT"]]}],"s":"MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPEEMKEDYDTMGPEATIQTAINNGTVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSNPPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIKPVEKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGEDGYGKLGRQDGDEEFEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSDHEEDNMEDGM"},{"id":"SEQ_06400","a":"Q9UIG4","g":"PSORS1C2","d":"Psoriasis susceptibility 1 candidate gene 2 protein","L":136,"m":[{"c":"P[GDE][DN]PWP[GAP][AG]P","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three 9-aa proline/tryptophan-anchored repeats in a disordered proline- and acidic-rich region sharing five invariant anchor residues (P..PWP..P) and tightly constrained flanking positions ([GDE], [DN], [GAP], [AG]), with one upstream copy and two nearly adjacent C-terminal copies separated by a 2-aa linker.","i":[[50,58,"PGDPWPGAP"],[97,105,"PDDPWPAGP"],[108,116,"PENPWPPAP"]]}],"s":"MILNWKLLGILVLCLHTRGISGSEGHPSHPPAEDREEAGSPTLPQGPPVPGDPWPGAPPLFEDPPPTRPSRPWRDLPETGVWLPEPPRTDPPQPPRPDDPWPAGPQPPENPWPPAPEVDNRPQEEPDLDPPREEYR"},{"id":"SEQ_06402","a":"Q0D2H9","g":"GOLGA8DP","d":"Putative golgin subfamily A member 8D","L":430,"m":[{"c":"Q[KEQ]ERL[RQP][EQ]","u":7,"sp":"tandem","x":"mixed","cf":"medium","why":"Beyond the generic amphipathic coiled-coil heptads in residues 1-214, residues 134-161 contain a localized 4-copy head-to-tail 7-aa sequence duplication with four invariant positions (Q.ERL..) and constrained polar/charged/proline substitutions, including a helix-perturbing proline in copy 3.","i":[[134,140,"QKERLRE"],[141,147,"QEERLQE"],[148,154,"QQERLPE"],[155,161,"QEERLQQ"]]}],"s":"MEWKLEQSMREQALLKAQLTQLKESLKEVQLERDEYAEHLKGERARWQQRMRKMSQEVCSLKKEKKHDKYRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGALQAQVEYNQRISLLNEGQKERLREQEERLQEQQERLPEQEERLQQLAEPQNSFKELNNENKSVLQLEQQVKELQEKLGKERLEAASQQKQQLTAQLSLMALPGEGHGGEHLDSEGEEAPRPMPSVPEDLESREAMSGFMDHLEEKADLSELVEKEELGFFQYYRERCHQKVYHPITKPGGSAKDAAPGGGHHQAGPGQGGDEGEAAGAAGDGVAAGGDYKGHSKFLVTAQNPAHEPSPGAPAPQELGAAHKHGDLCEVSLTDSVEPVQGEAREGSPHDNPTAQPIVQDHQEHPGLGSNCCVPFFCWAWLPRRRR"},{"id":"SEQ_06405","a":"Q5SSG8","g":"MUC21","d":"Mucin-21","L":566,"m":[{"c":"[TA][NIT][ST][EGD][SF][SHR][TV]xS[SNA][GER]x[SGN][TI][AV]","u":15,"sp":"tandem","x":"disordered_like","cf":"high","why":"Extensive head-to-tail tandem array of 28 highly conserved 15-aa Ser/Thr-rich disordered repeats (canonical TNSESSTTSSGASTA architecture) spanning residues 31-450 upstream of a C-terminal transmembrane-like segment.","i":[[31,45,"ANTGSSVISSGASTA"],[46,60,"TNSGSSVTSSGVSTA"],[61,75,"TISGSSVTSNGVSIV"],[76,90,"TNSEFHTTSSGISTA"],[91,105,"TNSEFSTVSSGISIA"],[106,120,"TNSESSTTSSGASTA"],[121,135,"TNSESSTPSSGASTA"],[136,150,"TNSDSSTTSSGASTA"],[151,165,"TNSDSSTTSSEASTA"],[166,180,"TNSESSTTSSGASTA"],[181,195,"TNSESSTVSSRASTA"],[196,210,"TNSESSTTSSGASTA"],[211,225,"TNSESRTTSNGAGTA"],[226,240,"TNSESSTTSSGASTA"],[241,255,"TNSESSTPSSGAGTA"],[256,270,"TNSESSTTSSGAGTA"],[271,285,"TNSESSTVSSGISTV"],[286,300,"TNSESSTPSSGANTA"],[301,315,"TNSESSTTSSGANTA"],[316,330,"TNSDSSTTSSGASTA"],[331,345,"TNSESSTTSSGASTA"],[346,360,"TNSESSTTSSGASTA"],[361,375,"TNSGSSTTSSGTSTA"],[376,390,"TNSESSTVSSGASTA"],[391,405,"TTSESSTTSSGASTA"],[406,420,"TNSESSTVSSGASTA"],[421,435,"TNSESSTTSSGANTA"],[436,450,"TNSGSSVTSAGSGTA"]]}],"s":"MKMQKGNVLLMFGLLLHLEAATNSNETSTSANTGSSVISSGASTATNSGSSVTSSGVSTATISGSSVTSNGVSIVTNSEFHTTSSGISTATNSEFSTVSSGISIATNSESSTTSSGASTATNSESSTPSSGASTATNSDSSTTSSGASTATNSDSSTTSSEASTATNSESSTTSSGASTATNSESSTVSSRASTATNSESSTTSSGASTATNSESRTTSNGAGTATNSESSTTSSGASTATNSESSTPSSGAGTATNSESSTTSSGAGTATNSESSTVSSGISTVTNSESSTPSSGANTATNSESSTTSSGANTATNSDSSTTSSGASTATNSESSTTSSGASTATNSESSTTSSGASTATNSGSSTTSSGTSTATNSESSTVSSGASTATTSESSTTSSGASTATNSESSTVSSGASTATNSESSTTSSGANTATNSGSSVTSAGSGTAALTGMHTTSHSASTAVSEAKPGGSLVPWEIFLITLVSVVAAVGLFAGLFFCVRNSLSLRNTFNTAVYHPHGLNHGLGPGPGGNHGAPHRPRWSPNWFWRRPVSSIAMEMSGRNSGP"},{"id":"SEQ_06414","a":"P27540","g":"ARNT","d":"Aryl hydrocarbon receptor nuclear translocator","L":789,"m":[{"c":"[CS]DD[DE]QxSxDKER[FL]AR","u":15,"sp":"tandem","x":"disordered_like","cf":"high","why":"Head-to-tail tandem 15-aa duplication in the N-terminal charged/polar region sharing 10 identical anchors (DD, Q, S, DKER, AR) plus conserved acidic [DE] and hydrophobic [FL] positions.","i":[[62,76,"CDDDQMSNDKERFAR"],[77,91,"SDDEQSSADKERLAR"]]}],"s":"MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFLRCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGSGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSKPLEKSDGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENFRNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTAEGVGVWPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYNNEEFPDLTMFPPFSE"},{"id":"SEQ_06415","a":"O60393","g":"NOBOX","d":"Homeobox protein NOBOX","L":691,"m":[{"c":"D[GP]x[LF]P[DE]L(x){4,6}CPQALG[HR]xP[GS][GS]","u":"22-24","sp":"tandem","x":"disordered_like","cf":"high","why":"Head-to-tail tandem 22-24 aa internal duplication in the proline-rich C-terminal region anchored by an N-terminal D..[LF]P[DE]L motif, a short FP[GT]P-containing linker of 4 or 6 residues, and an invariant CPQALG[HR]xP[GS][GS] core.","i":[[598,621,"DPCLPELPFPGPFCPQALGHPPGG"],[622,643,"DGYFPDLFPTPCPQALGRQPSS"]]}],"s":"MALLLTLTSPDLEGTWDTRDKDGFKAQEGPPLAVPEFPVCGLYRIYGVCGSFSSFFIIRCSLCALETLKSPQHDPLEIPEQSLKLIPLVSGKRELTRGQKAGEKPLAAGPGEEELLRGSAPHAQDTQSEELPPSCTISGEKKPPAVSGEATGADAGRLCPPPRSRAPHKDRTLARSRPQTQGEDCSLPVGEVKIGKRSYSPAPGKQKKPNAMGLAPTSSPGAPNSARATHNPVPCGSGRGPCHLANLLSTLAQSNQNRDHKQGPPEVTCQIRKKTRTLYRSDQLEELEKIFQEDHYPDSDKRREIAQTVGVTPQRIMVKGAGSLVAGWSGGGPTIETLELQSERSAVAWVWFQNRRAKWRKMEKLNGKESKDNPAAPGPASSQCSSAAEILPAVPMEPKPDPFPQESPLDTFPEPPMLLTSDQTLAPTQPSEGAQRVVTPPLFSPPPVRRADLPFPLGPVHTPQLMPLLMDVAGSDSSHKDGPCGSWGTSITLPPPCSYLEELEPQDYQQSNQPGPFQFSQAPQPPLFQSPQPKLPYLPTFPFSMPSSLTLPPPEDSLFMFPCGPSGGTSQGYCPGASSGQILMQPPAGNIGTASWSDPCLPELPFPGPFCPQALGHPPGGDGYFPDLFPTPCPQALGRQPSSALSWMPEGARPGTGPLLSKAKEEPPAASLDQPSALEEARGDDKNSHVP"},{"id":"SEQ_06424","a":"Q5JU85","g":"IQSEC2","d":"IQ motif and SEC7 domain-containing protein 2","L":1488,"m":[{"c":"R-xx[YF]xx","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Seven tightly clustered 7-aa repeats (0-3 aa linkers, including three contiguous head-to-tail copies) in the N-terminal disordered region anchored by an invariant N-terminal R, an invariant acidic residue (E/D) at position 2, and an invariant aromatic residue (Y/F) at position 5.","i":[[85,91,"RESQYQN"],[93,99,"RETQFHH"],[103,109,"RESQFHQ"],[112,118,"RDVGYPN"],[119,125,"REGAYQN"],[126,132,"REAVYRD"],[135,141,"RDASYPL"]]},{"c":"[PHS]P[HT]x[PS]x[SPG]PL","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four 9-aa copies separated by 0-6 aa linkers in the C-terminal proline/histidine/serine-rich disordered tail, anchored by invariant P2, P8, and C-terminal L9 residues (accounting for every leucine in the C-terminal 80 aa) along with conserved [HT]3 and [PS]5 positions.","i":[[1417,1425,"HPHHPQSPL"],[1432,1440,"PPHPSYPPL"],[1444,1452,"SPHTPHSPL"],[1453,1461,"PPTSPHGPL"]]}],"s":"MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRDLREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNREGAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHPGREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGENSRTVSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV"},{"id":"SEQ_06440","a":"A6NDK9","g":"GOLGA6C","d":"Golgin subfamily A member 6C","L":693,"m":[{"c":"x[EK]QxERL","u":7,"sp":"tandem","x":"structured_like","cf":"high","why":"Ten unbroken head-to-tail 7-residue copies (residues 361-430) go well beyond a generic coiled-coil or charged rod by conserving fixed Q at position 3 (8/10) and an invariant C-terminal RL dipeptide (9/10 RL, 10/10 L) alongside E/K-rich helical positions.","i":[[361,367,"CEQNERL"],[368,374,"REQQKTL"],[375,381,"QEQGERL"],[382,388,"RKQEQRL"],[389,395,"RKQEERL"],[396,402,"RKEEERL"],[403,409,"QKQEKRL"],[410,416,"WDQEERL"],[417,423,"WKKEERL"],[424,430,"QKQEERL"]]}],"s":"MWPQPYLPPHPMMLEESRQNKLAAAKKKLKEYQQRKSPGIPAGAKTKKKKTDSSPETTTSGGGHSPGDSQYQELAVALESSSVTINQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMEQLETINILTLEKADLKTTLYHTKRAARHFEEESKDLAGRLQYSLQRIQELERALSAVSTQQQEEDRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLDEEHLEAASQRNQQLETQLSLVALPGEGDGGQHLDSEEEEAPRPTPNIPEDLESREATSSFMDLPKEKADGTEQVERRELGFVQPSGVTDGMRESFTVYESQGAVPNTRHQEMEDVIRLAQKEEEMKVKLLELQELVLPLVGNHEGHGKFLIAAQNPADEPTPGAPAPQELGAAGEQDDFYEVSLDNNVEPAPGAAREGSPHDNPPVQQIVQLSPVMQDT"},{"id":"SEQ_06442","a":"P02810","g":"PRH1","d":"Salivary acidic proline-rich phosphoprotein 1/2","L":166,"m":[{"c":"G[KRP][PQ]QGPP[QP][QG][GQ]","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Six conserved 10-residue proline/glycine/glutamine-rich core motifs span the disordered C-terminal domain (residues 68-163) with invariant G1, Q4, G5, P6, P7 anchors and a basic K/R at position 2 in 5/6 copies, separated by 0-11 aa P/Q/H-rich linkers (forming larger 17-21 aa units across copies 1-4 and truncated tandem units in copies 5-6).","i":[[68,77,"GPQQGPPQQG"],[89,98,"GKPQGPPQQG"],[106,115,"GRPQGPPQQG"],[123,132,"GRPQGPPQQG"],[144,153,"GKPQGPPPQG"],[154,163,"GRPQGPPQGQ"]]}],"s":"MLLILLSVALLAFSSAQDLDEDVSQEDVPLVISDGGDSEQFIDEERQGPPLGGQQSQPSAGDGNQNDGPQQGPPQQGGQQQQGPPPPQGKPQGPPQQGGHPPPPQGRPQGPPQQGGHPRPPRGRPQGPPQQGGHQQGPPPPPPGKPQGPPPQGGRPQGPPQGQSPQ"},{"id":"SEQ_06444","a":"O60563","g":"CCNT1","d":"Cyclin-T1","L":726,"m":[{"c":"[LI]KM[RP]I","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three closely clustered 5-residue short linear motif repeats occur in the disordered C-terminal half (residues 437-484, separated by 18 and 15 aa linkers) featuring invariant K2, M3, and I5 anchors flanked by aliphatic L/I at position 1 and R/P at position 4.","i":[[437,441,"LKMPI"],[460,464,"LKMRI"],[480,484,"IKMRI"]]}],"s":"MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK"},{"id":"SEQ_06448","a":"Q15428","g":"SF3A2","d":"Splicing factor 3A subunit 2","L":464,"m":[{"c":"P[PQS]APGVH","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Twenty-two tandem 7-residue repeats span the proline-rich disordered C-terminal domain (residues 282-436, with only a single 1-residue P insertion between copies 12 and 13), strongly anchored by invariant N-terminal P and C-terminal GVH across nearly all copies.","i":[[282,288,"PPAPGVH"],[289,295,"PPAPVVH"],[296,302,"PPASGVH"],[303,309,"PPAPGVH"],[310,316,"PPAPGVH"],[317,323,"PPAPGVH"],[324,330,"PPTSGVH"],[331,337,"PPAPGVH"],[338,344,"PPAPGVH"],[345,351,"PPAPGVH"],[352,358,"PPAPGVH"],[359,365,"PPAPGVH"],[367,373,"PPSAGVH"],[374,380,"PQAPGVH"],[381,387,"PAAPAVH"],[388,394,"PQAPGVH"],[395,401,"PPAPGMH"],[402,408,"PQAPGVH"],[409,415,"PQPPGVH"],[416,422,"PSAPGVH"],[423,429,"PQPPGVH"],[430,436,"PSNPGVH"]]}],"s":"MDFQHRPGGKTGSGGVASSSESNRDRRERLRQLALETIDINKDPYFMKNHLGSYECKLCLTLHNNEGSYLAHTQGKKHQTNLARRAAKEAKEAPAQPAPEKVKVEVKKFVKIGRPGYKVTKQRDSEMGQQSLLFQIDYPEIAEGIMPRHRFMSAYEQRIEPPDRRWQYLLMAAEPYETIAFKVPSREIDKAEGKFWTHWNRETKQFFLQFHFKMEKPPAPPSLPAGPPGVKRPPPPLMNGLPPRPPLPESLPPPPPGGLPLPPMPPTGPAPSGPPGPPQLPPPAPGVHPPAPVVHPPASGVHPPAPGVHPPAPGVHPPAPGVHPPTSGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPPSAGVHPQAPGVHPAAPAVHPQAPGVHPPAPGMHPQAPGVHPQPPGVHPSAPGVHPQPPGVHPSNPGVHPPTPMPPMLRPPLPSEGPGNIPPPPPTN"},{"id":"SEQ_06462","a":"Q9Y520","g":"PRRC2C","d":"Translational regulator PRRC2C","L":2896,"m":[{"c":"[PL][AP]S[TP][SL]A[PS][VL]","u":8,"sp":"tandem","x":"disordered_like","cf":"high","why":"Six 8-residue tandem repeats in a P/A/S/T-rich disordered region (residues 1755-1809, interrupted once by a 7-residue degenerate unit PATLTPV and flanked by divergent variants PPLASAPL, PASTSAAA, and LASTSAPT) with invariant S3 and A6 anchors and tightly constrained 2-residue choices at all remaining positions.","i":[[1755,1762,"PPSTSASV"],[1763,1770,"PASTSAPL"],[1778,1785,"PASTSAPV"],[1786,1793,"PASTLAPV"],[1794,1801,"LASTSAPV"],[1802,1809,"PASPLAPV"]]},{"c":"R[AST]GPIKx[PQ]x[LI]","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 10-residue linear motifs across disordered regions (residues 1012-1021, 2091-2100, and 2879-2888) sharing five invariant anchor residues (R1, G3, P4, I5, K6) alongside a small [AST]2 position, polar/proline [PQ]8, and C-terminal aliphatic [LI]10.","i":[[1012,1021,"RSGPIKKPVL"],[2092,2101,"RAGPIKAQKL"],[2880,2889,"RTGPIKPQAI"]]},{"c":"Q[PQ]TSx[QT]Q[IP][PI][IP][PI][IL]Yxxx[QL]GQ","u":19,"sp":"dispersed","x":"mixed","cf":"medium","why":"Two 19-residue internal duplications separated by 69 residues in the C-terminal region (residues 2422-2440 and 2510-2528), anchored by an N-terminal Q[PQ]TSx[QT]Q polar segment, a central alternating proline-isoleucine/leucine aromatic core ([IP][PI][IP][PI][IL]Y), and a C-terminal [QL]GQ motif.","i":[[2422,2440,"QPTSVQQIPIPIYAPLQGQ"],[2511,2529,"QQTSNTQPIPILYEHQLGQ"]]},{"c":"[TVI][PT]ILAS[AV][SL]","u":8,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three closely spaced non-overlapping 8-residue repeats (residues 1841-1868, separated by 4 and 0 residues) downstream of the PASTSAPV array, anchored by an invariant ILAS core preceded by beta-branched [TVI]1 and [PT]2 positions.","i":[[1841,1848,"TPILASVS"],[1853,1860,"VTILASAS"],[1861,1868,"IPILASAL"]]}],"s":"MSEKSGQSTKAKDGKKYATLSLFNTYKGKSLETQKTTARHGLQSLGKVGISRRMPPPANLPSLKAENKGNDPNVNIVPKDGTGWASKQEQHEEEKTPEVPPAQPKPGVAAPPEVAPAPKSWASNKQGGQGDGIQVNSQFQQEFPSLQAAGDQEKKEKETNDDNYGPGPSLRPPNVACWRDGGKAAGSPSSSDQDEKLPGQDESTAGTSEQNDILKVVEKRIACGPPQAKLNGQQAALASQYRAMMPPYMFQQYPRMTYPPLHGPMRFPPSLSETNKGLRGRGPPPSWASEPERPSILSASELKELDKFDNLDAEADEGWAGAQMEVDYTEQLNFSDDDEQGSNSPKENNSEDQGSKASENNENKKETDEVSNTKSSSQIPAQPSVAKVPYGKGPSFNQERGTSSHLPPPPKLLAQQHPPPDRQAVPGRPGPFPSKQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQESENSCNKEEEPVFTRQDSNRSEKEATPVVHETEPESGSQPRPAVLSGYFKQFQKSLPPRFQRQQEQMKQQQWQQQQQQGVLPQTVPSQPSSSTVPPPPHRPLYQPMQPHPQHLASMGFDPRWLMMQSYMDPRMMSGRPAMDIPPIHPGMIPPKPLMRRDQMEGSPNSSESFEHIARSARDHAISLSEPRMLWGSDPYPHAEPQQATTPKATEEPEDVRSEAALDQEQITAAYSVEHNQLEAHPKADFIRESSEAQVQKFLSRSVEDVRPHHTDANNQSACFEAPDQKTLSAPQEERISAVESQPSRKRSVSHGSNHTQKPDEQRSEPSAGIPKVTSRCIDSKEPIERPEEKPKKEGFIRSSEGPKPEKVYKSKSETRWGPRPSSNRREEVNDRPVRRSGPIKKPVLRDMKEEREQRKEKEGEKAEKVTEKVVVKPEKTEKKDLPPPPPPPQPPAPIQPQSVPPPIQPEAEKFPSTETATLAQKPSQDTEKPLEPVSTVQVEPAVKTVNQQTMAAPVVKEEKQPEKVISKDLVIERPRPDSRPAVKKESTLPPRTYWKEARERDWFPDQGYRGRGRGEYYSRGRSYRGSYGGRGRGGRGHTRDYPQYRDNKPRAEHIPSGPLRQREESETRSESSDFEVVPKRRRQRGSETDTDSEIHESASDKDSLSKGKLPKREERPENKKPVKPHSSFKPDNHVRIDNRLLEKPYVRDDDKAKPGFLPKGEPTRRGRGGTFRRGGRDPGGRPSRPSTLRRPAYRDNQWNPRQSEVPKPEDGEPPRRHEQFIPIAADKRPPKFERKFDPARERPRRQRPTRPPRQDKPPRFRRLREREAASKSNEVVAVPTNGTVNNVAQEPVNTLGDISGNKTPDLSNQNSSDQANEEWETASESSDFNERRERDEKKNADLNAQTVVKVGENVLPPKREIAKRSFSSQRPVDRQNRRGNNGPPKSGRNFSGPRNERRSGPPSKSGKRGPFDDQPAGTTGVDLINGSSAHHQEGVPNGTGQKNSKDSTGKKREDPKPGPKKPKEKVDALSQFDLNNYASVVIIDDHPEVTVIEDPQSNLNDDGFTEVVSKKQQKRLQDEERRKKEEQVIQVWNKKNANEKGRSQTSKLPPRFAKKQATGIQQAQSSASVPPLASAPLPPSTSASVPASTSAPLPATLTPVPASTSAPVPASTLAPVLASTSAPVPASPLAPVSASASVSASVPASTSAAAITSSSAPASAPAPTPILASVSTPASVTILASASIPILASALASTSAPTPAPAASSPAAPVITAPTIPASAPTASVPLAPASASAPAPAPTPVSAPNPAPPAPAQTQAQTHKPVQNPLQTTSQSSKQPPPSIRLPSAQTPNGTDYVASGKSIQTPQSHGTLTAELWDNKVAPPAVLNDISKKLGPISPPQPPSVSAWNKPLTSFGSAPSSEGAKNGQESGLEIGTDTIQFGAPASNGNENEVVPVLSEKSADKIPEPKEQRQKQPRAGPIKAQKLPDLSPVENKEHKPGPIGKERSLKNRKVKDAQQVEPEGQEKPSPATVRSTDPVTTKETKAVSEMSTEIGTMISVSSAEYGTNAKESVTDYTTPSSSLPNTVATNNTKMEDTLVNNVPLPNTLPLPKRETIQQSSSLTSVPPTTFSLTFKMESARKAWENSPNVREKGSPVTSTAPPIATGVSSSASGPSTANYNSFSSASMPQIPVASVTPTASLSGAGTYTTSSLSTKSTTTSDPPNICKVKPQQLQTSSLPSASHFSQLSCMPSLIAQQQQNPQVYVSQSAAAQIPAFYMDTSHLFNTQHARLAPPSLAQQQGFQPGLSQPTSVQQIPIPIYAPLQGQHQAQLSLGAGPAVSQAQELFSSSLQPYRSQPAFMQSSLSQPSVVLSGTAIHNFPTVQHQELAKAQSGLAFQQTSNTQPIPILYEHQLGQASGLGGSQLIDTHLLQARANLTQASNLYSGQVQQPGQTNFYNTAQSPSALQQVTVPLPASQLSLPNFGSTGQPLIALPQTLQPPLQHTTPQAQAQSLSRPAQVSQPFRGLIPAGTQHSMIATTGKMSEMELKAFGSGIDIKPGTPPIAGRSTTPTSSPFRATSTSPNSQSSKMNSIVYQKQFQSAPATVRMTQPFPTQFAPQILSQPNLVPPLVRAPHTNTFPAPVQRPPMALASQMPPPLTTGLMSHARLPHVARGPCGSLSGVRGNQAQAALKAEQDMKAKQRAEVLQSTQRFFSEQQQSKQIGGGKAQKVDSDSSKPPETLTDPPGVCQEKVEEKPPPAPSIATKPVRTGPIKPQAIKTEETKS"},{"id":"SEQ_06464","a":"Q9Y5I3","g":"PCDHA1","d":"Protocadherin alpha-1","L":950,"m":[{"c":"(x){12,22}[GS](x){8,9}Dx[DG]xxxxxxψxxx[LF](x){23,28}[IL]Dx[EA](x){12,17}D(x){7,11}ψxψxψx-xxxxxxxx","u":"104-114","sp":"tandem","x":"structured_like","cf":"high","why":"Six tandem ~104-114 aa structured repeats spanning residues 30-679, anchored by conserved [GS](x){8,9}Dx[DG], an aliphatic-leucine/phenylalanine core (ψxxx[LF]), central [IL]Dx[EA], an alternating aliphatic strand (ψxψxψx), and a C-terminal DxNDN[AP]Px[FL] motif in copies 1-5 that diverges in copy 6.","i":[[30,133,"QLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVEVKVKDINDNPPVF"],[136,242,"REQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLF"],[243,350,"DQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPEL"],[351,455,"AVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAF"],[456,565,"AQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL"],[566,679,"LAPRVGGTIGAVSELVPRLVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARIPFRVGLYTGEISTTRVLDEADLSRYRLLVLVKDHGEPALTATATVLVSLVESGQAPKAS"]]}],"s":"MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVEVKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTIGAVSELVPRLVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARIPFRVGLYTGEISTTRVLDEADLSRYRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRASVGVAGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSVPPTEGAYVPGKPTLVCSSALGSWSNSQQRRQRVCSSEGPPKTDLMAFSPGLSPSLNTSERNEQPEANLDLSGNPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ"},{"id":"SEQ_06467","a":"Q92954","g":"PRG4","d":"Proteoglycan 4","L":1404,"m":[{"c":"[KED][EKG][PLT][ATS][PS]TTx","u":8,"sp":"tandem","x":"disordered_like","cf":"high","why":"Extensive 54-copy tandem octapeptide repeat array across the central disordered region (residues 348-848), strongly dominated by KEPAPTT[PT] with conserved charged N-terminal positions, central Pro-Ala-Pro core, and invariant di-threonine (TT) motif interspersed with occasional 5-7 aa length variants.","i":[[348,355,"KEPTPTTP"],[356,363,"KEPASTTP"],[364,371,"KEPTPTTI"],[379,386,"KEPAPTTT"],[394,401,"KEPAPTTT"],[402,409,"KEPAPTTP"],[410,417,"KEPAPTTT"],[418,425,"KEPAPTTT"],[433,440,"KEPAPTTP"],[441,448,"KKPAPTTP"],[449,456,"KEPAPTTP"],[457,464,"KEPTPTTP"],[472,479,"KEPAPTTP"],[488,495,"KKPAPTTP"],[496,503,"KEPAPTTP"],[504,511,"KEPAPTTT"],[512,519,"KEPSPTTP"],[520,527,"KEPAPTTT"],[535,542,"KEPAPTTT"],[550,557,"KEPSPTTT"],[558,565,"KEPAPTTP"],[566,573,"KEPAPTTP"],[574,581,"KKPAPTTP"],[582,589,"KEPAPTTP"],[590,597,"KEPAPTTT"],[598,605,"KKPAPTTP"],[606,613,"KEPAPTTP"],[614,621,"KETAPTTP"],[622,629,"KKLTPTTP"],[630,637,"EKLAPTTP"],[638,645,"EKPAPTTP"],[646,653,"EELAPTTP"],[654,661,"EEPTPTTP"],[662,669,"EEPAPTTP"],[678,685,"KEPAPTTP"],[686,693,"KEPAPTTP"],[694,701,"KEPAPTTP"],[702,709,"KETAPTTP"],[710,717,"KGTAPTTL"],[718,725,"KEPAPTTP"],[731,738,"KELAPTTT"],[739,746,"KEPTSTTS"],[747,754,"DKPAPTTP"],[755,762,"KGTAPTTP"],[763,770,"KEPAPTTP"],[771,778,"KEPAPTTP"],[779,786,"KGTAPTTL"],[787,794,"KEPAPTTP"],[800,807,"KELAPTTT"],[808,815,"KGPTSTTS"],[816,823,"DKPAPTTP"],[824,831,"KETAPTTP"],[832,839,"KEPAPTTP"],[840,847,"KKPAPTTP"]]},{"c":"-L(x){0,1}SCxGRCxExΩxRxxxC[ND]CDφoCx[HK]YxxCCPDΩxxφC","u":"38-39","sp":"tandem","x":"structured_like","cf":"high","why":"Two tandem 38-39 aa cysteine-rich structured repeats near the N-terminus (residues 26-104, separated by a 2-aa TA linker) sharing an identical 8-cysteine register alongside conserved -L, GRC, ExΩxR, CD, Y, and CCPDΩ anchors.","i":[[26,64,"DLSSCAGRCGEGYSRDATCNCDYNCQHYMECCPDFKRVC"],[67,104,"ELSCKGRCFESFERGRECDCDAQCKKYDKCCPDYESFC"]]}],"s":"MAWKTLPIYLLLLLSVFVIQQVSSQDLSSCAGRCGEGYSRDATCNCDYNCQHYMECCPDFKRVCTAELSCKGRCFESFERGRECDCDAQCKKYDKCCPDYESFCAEVHNPTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTSDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDETNICNGKPVDGLTTLRNGTLVAFRGHYFWMLSPFSPPSPARRITEVWGIPSPIDTVFTRCNCEGKTFFFKDSQYWRFTNDIKDAGYPKPIFKGFGGLTGQIVAALSTAKYKNWPESVYFFKRGGSIQQYIYKQEPVQKCPGRRPALNYPVYGETTQVRRRRFERAIGPSQTHTIRIQYSPARLAYQDKGVLHNEVKVSILWRGLPNVVTSAISLPNIRKPDGYDYYAFSKDQYYNIDVPSRTARAITTRSGQTLSKVWYNCP"},{"id":"SEQ_06472","a":"Q9Y2G9","g":"SBNO2","d":"Protein strawberry notch homolog 2","L":1366,"m":[{"c":"[DG][GQ][FQ]φxxYKxxxx+x[LS]xφ(x){6,8}","u":"23-25","sp":"dispersed","x":"structured_like","cf":"high","why":"Three closely spaced ~23-25 aa structured repeats (separated by a 6-aa linker and a 0-aa junction) sharing an ungapped 17-aa N-terminal core with conserved [DG][GQ][FQ]φ motif, invariant YK dyad, conserved basic (+) residue at +5 after YK, and hydrophobic (φ) anchor at +9.","i":[[1034,1058,"DGQVVFYKISVDRGLKWEDAFAKSL"],[1065,1087,"DGFYLSYKVRGNKPSCLLAEQNR"],[1088,1111,"GQFFTVYKPNIGRQSQLEALDSLR"]]}],"s":"MLAVGPAMDRDYPQHEPPPAGSLLYSPPPLQSAMLHCPYWNTFSLPPYPAFSSDSRPFMSSASFLGSQPCPDTSYAPVATASSLPPKTCDFAQDSSYFEDFSNISIFSSSVDSLSDIVDTPDFLPADSLNQVSTIWDDNPAPSTHDKLFQLSRPFAGFEDFLPSHSTPLLVSYQEQSVQSQPEEEDEAEEEEAEELGHTETYADYVPSKSKIGKQHPDRVVETSTLSSVPPPDITYTLALPSDSGALSALQLEAITYACQQHEVLLPSGQRAGFLIGDGAGVGKGRTVAGVILENHLRGRKKALWFSVSNDLKYDAERDLRDIEATGIAVHALSKIKYGDTTTSEGVLFATYSALIGESQAGGQHRTRLRQILDWCGEAFEGVIVFDECHKAKNAGSTKMGKAVLDLQNKLPLARVVYASATGASEPRNMIYMSRLGIWGEGTPFRNFEEFLHAIEKRGVGAMEIVAMDMKVSGMYIARQLSFSGVTFRIEEIPLAPAFECVYNRAALLWAEALNVFQQAADWIGLESRKSLWGQFWSAHQRFFKYLCIAAKVRRLVELAREELARDKCVVIGLQSTGEARTREVLGENDGHLNCFVSAAEGVFLSLIQKHFPSTKRKRDRGAGSKRKRRPRGRGAKAPRLACETAGVIRISDDSSTESDPGLDSDFNSSPESLVDDDVVIVDAVGLPSDDRGPLCLLQRDPHGPGVLERVERLKQDLLDKVRRLGRELPVNTLDELIDQLGGPQRVAEMTGRKGRVVSRPDGTVAFESRAEQGLSIDHVNLREKQRFMSGEKLVAIISEASSSGVSLQADRRVQNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVSAPEYVFLISELAGERRFASIVAKRLESLGALTHGDRRATESRDLSKYNFENKYGTRALHCVLTTILSQTENKVPVPQGYPGGVPTFFRDMKQGLLSVGIGGRESRNGCLDVEKDCSITKFLNRILGLEVHKQNALFQYFSDTFDHLIEMDKREGKYDMGILDLAPGIEEIYEESQQVFLAPGHPQDGQVVFYKISVDRGLKWEDAFAKSLALTGPYDGFYLSYKVRGNKPSCLLAEQNRGQFFTVYKPNIGRQSQLEALDSLRRKFHRVTAEEAKEPWESGYALSLTHCSHSAWNRHCRLAQEGKDCLQGLRLRHHYMLCGALLRVWGRIAAVMADVSSSSYLQIVRLKTKDRKKQVGIKIPEGCVRRVLQELRLMDADVKRRQAPALGCPAPPAPRPLALPCGPGEVLDLTYSPPAEAFPPPPHFSFPAPLSLDAGPGVVPLGTPDAQADPAALAHQGCDINFKEVLEDMLRSLHAGPPSEGALGEGAGAGGAAGGGPERQSVIQFSPPFPGAQAPL"},{"id":"SEQ_06488","a":"A6NF01","g":"POM121B","d":"Putative nuclear envelope pore membrane protein POM 121B","L":834,"m":[{"c":"[QKT]PxFGx","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Seven dispersed PxFG-type linear motifs across the C-terminal P/S/T-rich disordered region, anchored by invariant Pro, Phe, and Gly residues preceded by Q/K/T.","i":[[417,422,"KPAFGF"],[553,558,"QPAFGA"],[572,577,"TPSFGS"],[611,616,"QPTFGG"],[638,643,"QPAFGG"],[757,762,"KPVFGG"],[765,770,"TPTFGL"]]},{"c":"F[STL]FGx","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Six non-overlapping FxFG-type motifs interspersed across the same disordered FG-repeat domain, defined by dual Phe anchors flanking S/T/L and an invariant Gly.","i":[[288,292,"FLFGT"],[446,450,"FLFGA"],[579,583,"FTFGN"],[648,652,"FSFGA"],[682,686,"FTFGG"],[712,716,"FSFGA"]]}],"s":"MSRRVRTSELWKRNGPSSSPFSSPASSRSQTPERPAKKIREEEMCHHSSSSTPLAADKESQGEKAADTTPRKKQNSNSQSTPGSSGQRKRKVQLLPSRRGEQLTLPPPPQLGYSITAEDLDLEKKASLQWFNQALEDKSDAASNSVTETPPITQPSFTFTLPAAAPASPPTSLLAPSTNPLLESLKKMQTPPSLPPCPESAGAATTEALSPPKTPNLLPPLGLSQSGPPGLLPSPSFDSNPPTTLLGLIPAPSMVPATDTKAPPTLQAETTTKPQATSAPSPAPKQSFLFGTQNTSPSSPAAPAASSASPMFKPIFTAPPKSEKEGPTPPGPSVSATAPSSSSLPTTTSTTAPTFQPVFSSMGPPASVPLPAPFFKQTTTPATAPTTTAPLFTGLASATSAVAPITSASPSTDSASKPAFGFGINSVSSSSVSTTTSTATAASQPFLFGAPQASAASFTPAMGSIFQFGKPPALPTTTTVTTFSQSLPTAVPTATSSSAADFSGFGSTLATSAPATSSQPTLTFSNTSTPTFNIPFGSSAKSPLPSYPGANPQPAFGAAEGQPPGAAKPALTPSFGSSFTFGNSAAPAAAPTPAPPSMIKIVPAHVPTPIQPTFGGATHSAFGLKATASAFGAPASSQPAFGGSTAVFSFGAATSSGFGATTQTASSGSSSSVFGSTTPSPFTFGGSAAPAGSGSFGINVATPGSSATTGAFSFGAGQSGSTATSTPFAGGLGQNALGTTGQSTPFAFNVGSTTESKPVFGGTATPTFGLNTPAPGVGTSGSSLSFGASSAPAQGFVGVAPFGSAAPSFSIGAGSKTLGARQRLQARRQHTRKK"},{"id":"SEQ_06493","a":"Q9NQA3","g":"WASH6P","d":"WAS protein family homolog 6","L":447,"m":[{"c":"GGWxoψx[QE]SxxQφx[AG]IG(x){0,1}KφxLxoφKxxKψ","u":"29-30","sp":"dispersed","x":"structured_like","cf":"high","why":"Strongly conserved 29-30 aa internal duplication near the N- and C-termini sharing an invariant GGW cap, SxxQφx[AG]IG core, and amphipathic basic KφxLxoφKxxKψ helical segment separated by a 1-residue indel.","i":[[32,61,"GGWKQVEQSRSQVQAIGEKVSLAQAKIEKI"],[342,370,"GGWATLLESIRQAGGIGKAKLRSMKERKL"]]},{"c":"[YL]x[PA]DL[GPQ]","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed short motifs in the central proline-rich disordered region anchored by an invariant DL dipeptide preceded by P/A and an N-terminal Tyr (in the first three copies) or Leu.","i":[[216,221,"YVPDLG"],[231,236,"YLPDLP"],[244,249,"YSADLG"],[274,279,"LKADLQ"]]}],"s":"MAFHEMQAHKNALGTSGEQQAADITGPTPHQGGWKQVEQSRSQVQAIGEKVSLAQAKIEKIKGSKKAIKVFSSAKYPAPERLQEYGSIFTGAQDPGLQRRPRHRIQSKHRPLDERALQEKLKDFPVCVSTKPEPEDDAEEGLGGLPSNISSVSSLLLFNTTENLYKKYVFLDPLAGAVTKTHVMLGAETEEKLFDAPLSISKREQLEQQVPENYFYVPDLGQVPEIDVPSYLPDLPSIANDLMYSADLGPGIAPSAPGTIPELPTFHTEVAEPLKADLQDGVLTPPPPPPPPPPAPEVLASAPPLPPSTAAPVGQGARQDDGSSSASPSVQGAPREVVDPSGGWATLLESIRQAGGIGKAKLRSMKERKLEKKKQKEQEQVRATSQGGHLMSDLFNKLVMRRKGISGKGPGAGEGPGGAFARVSDSIPPVPPPQQPQAEEDEDDWES"},{"id":"SEQ_06507","a":"Q9H2A3","g":"NEUROG2","d":"Neurogenin-2","L":272,"m":[{"c":"S[GS]xS[PS]o[PS][AT]S[TP][WY]SCT[NL]SPA(x){0,1}P[SA]","u":"20-21","sp":"tandem","x":"disordered_like","cf":"high","why":"High-conservation 20-21 aa head-to-tail tandem duplication in the C-terminal S/P-rich disordered region sharing a conserved [WY]SCT[NL]SPA(x){0,1}P[SA] core and matching N-terminal Ser/Pro positions.","i":[[204,223,"SGDSPSPASTWSCTNSPAPS"],[224,244,"SSVSSNSTSPYSCTLSPASPA"]]}],"s":"MFVKSETLELKEEEDVLVLLGSASPALAALTPLSSSADEEEEEEPGASGGARRQRGAEAGQGARGGVAAGAEGCRPARLLGLVHDCKRRPSRARAVSRGAKTAETVQRIKKTRRLKANNRERNRMHNLNAALDALREVLPTFPEDAKLTKIETLRFAHNYIWALTETLRLADHCGGGGGGLPGALFSEAVLLSPGGASAALSSSGDSPSPASTWSCTNSPAPSSSVSSNSTSPYSCTLSPASPAGSDMDYWQPPPPDKHRYAPHLPIARDCI"},{"id":"SEQ_06513","a":"Q13191","g":"CBLB","d":"E3 ubiquitin-protein ligase CBL-B","L":982,"m":[{"c":"DxASxxVPLPPARxxxx-NxK(x){1,5}NRT[PS]oDYDxLx[PS]","u":"34-38","sp":"dispersed","x":"disordered_like","cf":"high","why":"Strongly conserved 34-38 aa internal duplication in the C-terminal disordered region pairing an N-terminal DxASxxVPLPPARxxxx-NxK proline-arginine block with a C-terminal NRT[PS]oDYDxLx[PS] tyrosine-acidic motif separated by a 1-5 aa variable linker.","i":[[770,807,"DSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIP"],[861,894,"DLASGQVPLPPARRLPGENVKTNRTSQDYDQLPS"]]},{"c":"L[PS][ALP]PP[PV]P[ALP]R","u":9,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Dispersed 9-aa proline-rich motif in the disordered C-terminal half anchored at both ends by fixed N-terminal L and C-terminal R residues around a conserved PP[PV]P core.","i":[[502,510,"LSLPPVPPR"],[544,552,"LPAPPPPLR"],[821,829,"LPPPPPPAR"]]}],"s":"MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL"},{"id":"SEQ_06514","a":"P55884","g":"EIF3B","d":"Eukaryotic translation initiation factor 3 subunit B","L":814,"m":[{"c":"xxφx[WF]x[PHK]x[GE]xxφxxxx(x){3,13}φxφφ","u":"23-33","sp":"periodic","x":"structured_like","cf":"high","why":"Eight periodic 23-33 aa beta-propeller-like repeat units separated by regular 16-19 aa linkers, anchored by a conserved N-terminal φx[WF]x[PHK]x[GE]xxφ turn-strand motif and a C-terminal φxφφ hydrophobic beta-strand.","i":[[338,360,"TYVRWSPKGTYLATFHQRGIALW"],[377,407,"QLIDFSPCERYLVTFSPLMDTQDDPQAIIIW"],[427,449,"PIFKWSHDGKFFARMTLDTLSIY"],[468,496,"KDFSWSPGGNIIAFWVPEDKDIPARVTLM"],[515,547,"CKLHWQKNGDYLCVKVDRTPKGTQGVVTNFEIF"],[566,592,"IAFAWEPNGSKFAVLHGEAPRISVSFY"],[612,638,"NTIFWSPQGQFVVLAGLRSMNGALAFV"],[655,684,"SDVEWDPTGRYVVTSVSWWSHKVDNAYWLW"]]}],"s":"MQDAENVAVPEAAEERAEPGQQQPAAEPPPAEGLLRPAGPGAPEAAGTEASSEEVGIAEAGPESEVRTEPAAEAEAASGPSESPSPPAAEELPGSHAEPPVPAQGEAPGEQARDERSDSRAQAVSEDAGGNEGRAAEAEPRALENGDADEPSFSDPEDFVDDVSEEELLGDVLKDRPQEADGIDSVIVVDNVPQVGPDRLEKLKNVIHKIFSKFGKITNDFYPEEDGKTKGYIFLEYASPAHAVDAVKNADGYKLDKQHTFRVNLFTDFDKYMTISDEWDIPEKQPFKDLGNLRYWLEEAECRDQYSVIFESGDRTSIFWNDVKDPVSIEERARWTETYVRWSPKGTYLATFHQRGIALWGGEKFKQIQRFSHQGVQLIDFSPCERYLVTFSPLMDTQDDPQAIIIWDILTGHKKRGFHCESSAHWPIFKWSHDGKFFARMTLDTLSIYETPSMGLLDKKSLKISGIKDFSWSPGGNIIAFWVPEDKDIPARVTLMQLPTRQEIRVRNLFNVVDCKLHWQKNGDYLCVKVDRTPKGTQGVVTNFEIFRMREKQVPVDVVEMKETIIAFAWEPNGSKFAVLHGEAPRISVSFYHVKNNGKIELIKMFDKQQANTIFWSPQGQFVVLAGLRSMNGALAFVDTSDCTVMNIAEHYMASDVEWDPTGRYVVTSVSWWSHKVDNAYWLWTFQGRLLQKNNKDRFCQLLWRPRPPTLLSQEQIKQIKKDLKKYSKIFEQKDRLSQSKASKELVERRRTMMEDFRKYRKMAQELYMEQKNERLELRGGVDTDELDSNVDDWEEETIEFFVTEEIIPLGNQE"},{"id":"SEQ_06518","a":"Q7Z4S6","g":"KIF21A","d":"Kinesin-like protein KIF21A","L":1674,"m":[{"c":"[GPA][HE]xxxxxxφx(x){12,17}xxx+x[WF][DNK]","u":"29-34","sp":"periodic","x":"structured_like","cf":"high","why":"Seven C-terminal 29-34 aa beta-propeller-like repeats separated predominantly by 11-17 aa linkers (with one longer linker between copies 2 and 3), anchored by an N-terminal [GPA][HE]xxxxxxφ motif, internal hydrophobic beta-strand, and C-terminal +x[WF][DNK] signature.","i":[[1345,1373,"GHTKAVLCVDSTDDLLFTGSKDRTCKVWN"],[1385,1414,"GHPNNVVSVKYCNYTSLVFTVSTSYIKVWD"],[1450,1478,"GENQINQIALNPTGTFLYAASGNAVRMWD"],[1490,1523,"GHLGPVMCLTVDQISSGQDLIITGSKDHYIKMFD"],[1541,1569,"PHYDGIEALTIQGDNLFSGSRDNGIKKWD"],[1582,1612,"AHKDWVCALGVVPDHPVLLSGCRGGILKVWN"],[1624,1652,"GHDSPINAICVNSTHIFTAADDRTVRIWK"]]}],"s":"MLGAPDESSVRVAVRIRPQLAKEKIEGCHICTSVTPGEPQVFLGKDKAFTFDYVFDIDSQQEQIYIQCIEKLIEGCFEGYNATVFAYGQTGAGKTYTMGTGFDVNIVEEELGIISRAVKHLFKSIEEKKHIAIKNGLPAPDFKVNAQFLELYNEEVLDLFDTTRDIDAKSKKSNIRIHEDSTGGIYTVGVTTRTVNTESEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVCPQIDADNATDNKIISESAQMNEFETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSKRATHVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQDRASQQINALRSEITRLQMELMEYKTGKRIIDEEGVESINDMFHENAMLQTENNNLRVRIKAMQETVDALRSRITQLVSDQANHVLARAGEGNEEISNMIHSYIKEIEDLRAKLLESEAVNENLRKNLTRATARAPYFSGSSTFSPTILSSDKETIEIIDLAKKDLEKLKRKEKRKKKRLQKLEESNREERSVAGKEDNTDTDQEKKEEKGVSERENNELEVEESQEVSDHEDEEEEEEEEEDDIDGGESSDESDSESDEKANYQADLANITCEIAIKQKLIDELENSQKRLQTLKKQYEEKLMMLQHKIRDTQLERDQVLQNLGSVESYSEEKAKKVRSEYEKKLQAMNKELQRLQAAQKEHARLLKNQSQYEKQLKKLQQDVMEMKKTKVRLMKQMKEEQEKARLTESRRNREIAQLKKDQRKRDHQLRLLEAQKRNQEVVLRRKTEEVTALRRQVRPMSDKVAGKVTRKLSSSDAPAQDTGSSAAAVETDASRTGAQQKMRIPVARVQALPTPATNGNRKKYQRKGLTGRVFISKTARMKWQLLERRVTDIIMQKMTISNMEADMNRLLKQREELTKRREKLSKRREKIVKENGEGDKNVANINEEMESLTANIDYINDSISDCQANIMQMEEAKEEGETLDVTAVINACTLTEARYLLDHFLSMGINKGLQAAQKEAQIKVLEGRLKQTEITSATQNQLLFHMLKEKAELNPELDALLGHALQDLDSVPLENVEDSTDEDAPLNSPGSEGSTLSSDLMKLCGEVKPKNKARRRTTTQMELLYADSSELASDTSTGDASLPGPLTPVAEGQEIGMNTETSGTSAREKELSPPPGLPSKIGSISRQSSLSEKKIPEPSPVTRRKAYEKAEKSKAKEQKHSDSGTSEASLSPPSSPPSRPRNELNVFNRLTVSQGNTSVQQDKSDESDSSLSEVHRSSRRGIINPFPASKGIRAFPLQCIHIAEGHTKAVLCVDSTDDLLFTGSKDRTCKVWNLVTGQEIMSLGGHPNNVVSVKYCNYTSLVFTVSTSYIKVWDIRDSAKCIRTLTSSGQVTLGDACSASTSRTVAIPSGENQINQIALNPTGTFLYAASGNAVRMWDLKRFQSTGKLTGHLGPVMCLTVDQISSGQDLIITGSKDHYIKMFDVTEGALGTVSPTHNFEPPHYDGIEALTIQGDNLFSGSRDNGIKKWDLTQKDLLQQVPNAHKDWVCALGVVPDHPVLLSGCRGGILKVWNMDTFMPVGEMKGHDSPINAICVNSTHIFTAADDRTVRIWKARNLQDGQISDTGDLGEDIASN"},{"id":"SEQ_06525","a":"P0CJ87","g":"DUX4L4","d":"Double homeobox protein 4-like protein 4","L":422,"m":[{"c":"GRR+RxφφT[PG]SQ[ST]xφLxxxFE+[ND]xΩPGIA[TA]RExLAxxxGψPE[PS]RψQIWFQNxR[SA]R","u":55,"sp":"dispersed","x":"structured_like","cf":"high","why":"Strongly conserved 55-aa two-copy structured repeat near the N-terminus (30/55 identical residues including GRR+R, T[PG]SQ, FE, ΩPGIAxRExLA, GψPE, and RψQIWFQNxRxR), separated by a 20-aa linker.","i":[[19,73,"GRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSR"],[94,148,"GRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRAR"]]}],"s":"MALPTPSDSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQHRRESRPWPGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARHPGQGGRAPAQAGGLCSAAPGGGHPAPSWVAFAHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGVSQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLPGPCAVAQPGPAQAGPQGQGVLAPPTSQGSPWWGWGRGPQVAGAAWEPQAGEAPPPQPAPPDASARQGQMQGIPAPSQALQEPAPWSALPCGLLLDELLASPEFLQQAQPLLETEAPGELEASEEAASLEAPLSEEEYRALLEEL"},{"id":"SEQ_06531","a":"Q9HC78","g":"ZBTB20","d":"Zinc finger and BTB domain-containing protein 20","L":741,"m":[{"c":"x[GE]x[KRT]x[YH][EQV]C[STY]ψCx[KRA]xF[TSD]x[KI]xxφxxHψxxH","u":28,"sp":"tandem","x":"structured_like","cf":"high","why":"Five 28-aa Cys2His2-like repeats defined by invariant CxxC...F...HxxxH anchors, conserved hydrophobic core positions (ψ, φ), and an N-terminal [GE]x[KRT]x linker; the first four units form a contiguous head-to-tail tandem array and the fifth follows a 25-aa G/P-rich linker.","i":[[573,600,"GEKKPYECTLCNKTFTAKQNYVKHMFVH"],[601,628,"TGEKPHQCSICWRSFSLKDYLIKHMVTH"],[629,656,"TGVRAYQCSICNKRFTQKSSLNVHMRLH"],[657,684,"RGEKSYECYICKKKFSHKTLLERHVALH"],[710,737,"TEGTTYVCSVCPAKFDQIEQFNDHMRMH"]]}],"s":"MLERKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVSHHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTEDTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITVSNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQFVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGEKPHQCSICWRSFSLKDYLIKHMVTHTGVRAYQCSICNKRFTQKSSLNVHMRLHRGEKSYECYICKKKFSHKTLLERHVALHSASNGTPPAGTPPGARAGPPGVVACTEGTTYVCSVCPAKFDQIEQFNDHMRMHVSDG"},{"id":"SEQ_06532","a":"O00267","g":"SUPT5H","d":"Transcription elongation factor SPT5","L":1087,"m":[{"c":"[RQ]TPx[YQH][GDS][SG]","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Seven tandem 7-residue repeats (<=2 aa gaps) in a disordered Pro/Ser/Gly-rich linker, anchored by an invariant TP dipeptide, alternating [RQ] at position 1, [YQH] at position 5, and [GDS][SG] at the C-terminus.","i":[[767,773,"RTPMYGS"],[774,780,"QTPMYGS"],[783,789,"RTPMYGS"],[790,796,"QTPLQDG"],[798,804,"RTPHYGS"],[805,811,"QTPLHDG"],[813,819,"RTPAQSG"]]},{"c":"[TSA][PH]SPx[ASG]Y","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Seven non-overlapping 7-residue copies in the adjacent C-terminal disordered proline-rich region, defined by invariant SP at positions 3-4, a C-terminal [ASG]Y anchor, and [TSA][PH] at positions 1-2.","i":[[845,851,"TPSPQAY"],[905,911,"SPSPQSY"],[915,921,"APSPAGY"],[924,930,"THSPASY"],[933,939,"TPSPMAY"],[944,950,"SPSPVGY"],[957,963,"APSPGGY"]]},{"c":"xxxxψx(x){6,14}Gx[IL]xxxxxxxxxψxxxxx","u":"30-38","sp":"dispersed","x":"structured_like","cf":"medium","why":"Eight divergent beta-strand-rich globular repeats distributed across the structured N- and C-terminal scaffold, sharing a hydrophobic first strand (invariant ψ at position 5), a variable turn, an invariant Gx[IL] beta-strand motif, and a conserved aliphatic core residue 10 positions downstream.","i":[[211,240,"QIKSVVAPEHVKGYIYVEAYKQTHVKQAIE"],[356,387,"GDFLIFEGNRYSRKGFLFKSFAMSAVITEGVK"],[424,455,"DNVEVCEGELINLQGKILSVDGNKITIMPKHE"],[476,507,"DHVKVIAGRFEGDTGLIVRVEENFVILFSDLT"],[535,565,"EWGELVQLDPQTVGVIVRLERETFQVLNMYG"],[596,629,"VKDIVKVIDGPHSGREGEIRHLFRSFAFLHCKKL"],[982,1019,"TDIQVKVRDTYLDTQVVGQTGVIRSVTGGMCSVYLKDS"],[1039,1070,"NKVKVILGEDREATGVLLSIDGEDGIVRMDLD"]]}],"s":"MSDSEDSNFSEEEDSERSSDGEEAEVDEERRSAAGSEKEEEPEDEEEEEEEEEYDEEEEEEDDDRPPKKPRHGGFILDEADVDDEYEDEDQWEDGAEDILEKEEIEASNIDNVVLDEDRSGARRLQNLWRDQREEELGEYYMKKYAKSSVGETVYGGSDELSDDITQQQLLPGVKDPNLWTVKCKIGEERATAISLMRKFIAYQFTDTPLQIKSVVAPEHVKGYIYVEAYKQTHVKQAIEGVGNLRLGYWNQQMVPIKEMTDVLKVVKEVANLKPKSWVRLKRGIYKDDIAQVDYVEPSQNTISLKMIPRIDYDRIKARMSLKDWFAKRKKFKRPPQRLFDAEKIRSLGGDVASDGDFLIFEGNRYSRKGFLFKSFAMSAVITEGVKPTLSELEKFEDQPEGIDLEVVTESTGKEREHNFQPGDNVEVCEGELINLQGKILSVDGNKITIMPKHEDLKDMLEFPAQELRKYFKMGDHVKVIAGRFEGDTGLIVRVEENFVILFSDLTMHELKVLPRDLQLCSETASGVDVGGQHEWGELVQLDPQTVGVIVRLERETFQVLNMYGKVVTVRHQAVTRKKDNRFAVALDSEQNNIHVKDIVKVIDGPHSGREGEIRHLFRSFAFLHCKKLVENGGMFVCKTRHLVLAGGSKPRDVTNFTVGGFAPMSPRISSPMHPSAGGQRGGFGSPGGGSGGMSRGRGRRDNELIGQTVRISQGPYKGYIGVVKDATESTARVELHSTCQTISVDRQRLTTVGSRRPGGMTSTYGRTPMYGSQTPMYGSGSRTPMYGSQTPLQDGSRTPHYGSQTPLHDGSRTPAQSGAWDPNNPNTPSRAEEEYEYAFDDEPTPSPQAYGGTPNPQTPGYPDPSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPASYHPTPSPMAYQASPSPSPVGYSPMTPGAPSPGGYNPHTPGSGIEQNSSDWVTTDIQVKVRDTYLDTQVVGQTGVIRSVTGGMCSVYLKDSEKVVSISSEHLEPITPTKNNKVKVILGEDREATGVLLSIDGEDGIVRMDLDEQLKILNLRFLGKLLEA"},{"id":"SEQ_06555","a":"O95613","g":"PCNT","d":"Pericentrin","L":3336,"m":[{"c":"[VI][SNG]DH[PQT][PA]EQ[RHC]G[MI]FT","u":13,"sp":"tandem","x":"disordered_like","cf":"high","why":"Eight head-to-tail tandem 13-aa copies in the N-terminal disordered region anchored by seven invariant positions (D, H, E, Q, G, F, T) and six tightly constrained 2-3 residue positions.","i":[[109,121,"VNDHPPEQCGMFT"],[122,134,"VSDHPPEQHGMFT"],[135,147,"VGDHPPEQRGMFT"],[148,160,"VSDHPPEQHGMFT"],[161,173,"VSDHPPEQRGMFT"],[174,186,"ISDHQPEQRGMFT"],[187,199,"VSDHTPEQRGIFT"],[200,212,"ISDHPAEQRGMFT"]]},{"c":"ID[TA]CDANT[AT][TP]GGVTDVIKN","u":19,"sp":"tandem","x":"disordered_like","cf":"high","why":"Two highly conserved 19-aa tandem copies (separated by a 2-aa QA gap) in the central disordered region sharing 16 of 19 identical residues including fixed ID, CDANT, and GGVTDVIKN anchors.","i":[[2126,2144,"IDTCDANTATGGVTDVIKN"],[2147,2165,"IDACDANTTPGGVTDVIKN"]]}],"s":"MEVEQEQRRRKVEAGRTKLAHFRQRKTKGDSSHSEKKTAKRKGSAVDASVQEESPVTKEDSALCGGGDICKSTSCDDTPDGAGGAFAAQPEDCDGEKREDLEQLQQKQVNDHPPEQCGMFTVSDHPPEQHGMFTVGDHPPEQRGMFTVSDHPPEQHGMFTVSDHPPEQRGMFTISDHQPEQRGMFTVSDHTPEQRGIFTISDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQVELDRRQARRATAHTRVPGAHPQPRMDGGAKAQVTGDVEASHDAALEPVVPDPQGDLQPVLVTLKDAPLCKQEGVMSVLTVCQRQLQSELLLVKNEMRLSLEDGGKGKEKVLEDCQLPKVDLVAQVKQLQEKLNRLLYSMTFQNVDAADTKSLWPMASAHLLESSWSDDSCDGEEPDISPHIDTCDANTATGGVTDVIKNQAIDACDANTTPGGVTDVIKNWDSLIPDEMPDSPIQEKSECQDMSLSSPTSVLGGSRHQSHTAEAGPRKSPVGMLDLSSWSSPEVLRKDWTLEPWPSLPVTPHSGALSLCSADTSLGDRADTSLPQTQGPGLLCSPGVSAAALALQWAESPPADDHHVQRTAVEKDVEDFITTSFDSQETLSSPPPGLEGKADRSEKSDGSGFGARLSPGSGGPEAQTAGPVTPASISGRFQPLPEAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLHGGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLKHHLQKGCSPSRSERSAWKPDETAPQSSLRRPDPGRLPPAASEEAHTSNVKMEKLYLHYLRAESFRKALIYQKKYLLLLIGGFQDSEQETLSMIAHLGVFPSKAERKITSRPFTRFRTAVRVVIAILRLRFLVKKWQEVDRKGALAQGKAPRPGPRARQPQSPPRTRESPPTRDVPSGHTRDPARGRRLAAAASPHSGGRATPSPNSRLERSLTASQDPEHSLTEYIHHLEVIQQRLGGVLPDSTSKKSCHPMIKQ"},{"id":"SEQ_06559","a":"O43918","g":"AIRE","d":"Autoimmune regulator","L":545,"m":[{"c":"C[AG]VCxDGx-ψψxCxxCxxAFHφxCxxPxxxxxPxxxφRCxSC","u":42,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 42-aa cysteine-rich structured repeats separated by a 93-aa proline-rich linker, sharing seven invariant cysteines (CxxC-x8-CxxC-x7-C-x14-CxxC), fixed V, D, G, A, F, H, P, R, S anchors, and conserved acidic/aliphatic/hydrophobic positions.","i":[[299,340,"CAVCRDGGELICCDGCPRAFHLACLSPPLREIPSGTWRCSSC"],[434,475,"CGVCGDGTDVLRCTHCAAAFHWRCHFPAGTSRPGTGLRCRSC"]]}],"s":"MATDAALRRLLRLHRTEIAVAVDSAFPLLHALADHDVVPEDKFQETLHLKEKEGCPQAFHALLSWLLTQDSTAILDFWRVLFKDYNLERYGRLQPILDSFPKDVDLSQPRKGRKPPAVPKALVPPPRLPTKRKASEEARAAAPAALTPRGTASPGSQLKAKPPKKPESSAEQQRLPLGNGIQTMSASVQRAVAMSSGDVPGARGAVEGILIQQVFESGGSKKCIQVGGEFYTPSKFEDSGSGKNKARSSSGPKPLVRAKGAQGAAPGGGEARLGQQGSVPAPLALPSDPQLHQKNEDECAVCRDGGELICCDGCPRAFHLACLSPPLREIPSGTWRCSSCLQATVQEVQPRAEEPRPQEPPVETPLPPGLRSAGEEVRGPPGEPLAGMDTTLVYKHLPAPPSAAPLPGLDSSALHPLLCVGPEGQQNLAPGARCGVCGDGTDVLRCTHCAAAFHWRCHFPAGTSRPGTGLRCRSCSGDVTPAPVEGVLAPSPARLAPGPAKDDTASHEPALHRDDLESLLSEHTFDGILQWAIQSMARPAAPFPS"},{"id":"SEQ_06576","a":"Q76N89","g":"HECW1","d":"E3 ubiquitin-protein ligase HECW1","L":1606,"m":[{"c":"LPxxWEφ+xDoxG+xFΩVDHxoRxTTΩxxP","u":30,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 30-aa structured repeats separated by a ~157-aa linker, sharing 14 identical anchors (LP, WE, D, G, F, VDH, R, TT, P) and 7 additional physicochemically conserved positions with zero indels.","i":[[831,860,"LPPNWEARIDSHGRVFYVDHVNRTTTWQRP"],[1020,1049,"LPRGWEIKTDQQGKSFFVDHNSRATTFIDP"]]},{"c":"SxSCY","u":5,"sp":"tandem","x":"disordered_like","cf":"high","why":"Six head-to-tail tandem pentapeptide copies embedded in the central polar/proline-rich disordered region, anchored by invariant S at positions 1 and 3 and fixed C-Y residues at positions 4-5.","i":[[679,683,"SPSCY"],[684,688,"SSSCY"],[689,693,"STSCY"],[694,698,"SSSCY"],[699,703,"SASCY"],[704,708,"SPSCY"]]}],"s":"MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHDGVTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEVLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVKNSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPDDEEISLSTEPESAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDGPGNQSIELSRPAEEAAVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEAPASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPVSELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDGLSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESDSSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRFSSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE"},{"id":"SEQ_06584","a":"Q9UK61","g":"TASOR","d":"Protein TASOR","L":1670,"m":[{"c":"Qo[AS]LLE(x){4,10}LDSx-xxSxxxVCS","u":"24-30","sp":"dispersed","x":"disordered_like","cf":"high","why":"Two duplicated bipartite motifs in the C-terminal disordered region sharing a conserved N-terminal Qo[AS]LLE segment and C-terminal LDSx-xxSxxxVCS segment separated by a short variable polar/acidic loop (4 vs 10 aa), anchored by unique LDS and VCS tripeptides found nowhere else in the protein.","i":[[1493,1522,"QSALLENDEKDEEDMSLDSGDEISHIEVCS"],[1556,1579,"QNSLLEDKTYLDSEERTSIDIVCS"]]}],"s":"MATAVETEACQPTDASWESGGGGDDEMKQALPELESSQQNGGGGGLNIAEPSGGAGREENAGAEAAQSLSHEQPQDSSEAGAAALPRGPEEPERPVRRSFQIPRKSREKKALFQPLTPGSREFEDVVNILHSSYLEPTSVTNFNYRRACLVHNELLEKEFTEKRRELKFDGRLDKELSESYAFLMVDRYQVQTICEKGLHVGQSKITILGSPSMGVYLSRYADLLQANPLDTGAMGDVVIFKIMKGKIKSIYDPMGVKSLESMLNKSALDPTPKHECHVSKNANRITSLLAYRAYELTQYYFYEYGFDELRRRPRHVCPYAVVSFTYKDDIQTPKFVPSSRSNSFNTDRNIDKYNYTLWKGQLLNKGKLLCYISLRSATRAFLPIKLPEKLDVETVMSIDHLKQKIPPALFYKETYLGPNEVLKNGMYCSLYEVVEKTRIGSNMESLLQKLDREKLVLVKPLGDRGYLFLLSPYQMVPPYEYQTAKSRVLHALFLFQEPRSIVTSQKGSTNAAPQERHESMPDVLKIAQFLQFSLIQCRKEFKNISAINFHSVVEKYVSEFFKRGFGSGKREFIMFPYDSRLDDKKFLYSAPRNKSHIDTCLHAYIFRPEVYQLPICKLKELFEENRKLQQFSPLSDYEGQEEEMNGTKMKFGKRNNSRGEAIISGKQRSSHSLDYDKDRVKELINLIQCRKKSVGGDSDTEDMRSKTVLKRKLEDLPENMRKLAKTSNLSENCHLYEESPQPIGSLGHDADLRRQQQDTCNSGIADIHRLFNWLSETLANARHSDASLTDTVNKALGLSTDDAYEELRQKHEYELNSTPDKKDYEQPTCAKVENAQFKGTQSLLLEVDATSKYSVAISTSEVGTDHKLHLKEDPNLISVNNFEDCSLCPSVPIEHGFRRQQSKSNNVEETEIHWKLIPITGGNARSPEDQLGKHGEKQTPGMKSPEEQLVCVPPQEAFPNDPRVINRQRSSDYQFPSSPFTDTLKGTTEDDVLTGQVEEQCVPAAEAEPPAVSETTERTVLGEYNLFSRKIEEILKQKNVSYVSTVSTPIFSTQEKMKRLSEFIYSKTSKAGVQEFVDGLHEKLNTIIIKASAKGGNLPPVSPNDSGAKIASNPLERHVIPVSSSDFNNKHLLEPLCSDPLKDTNSDEQHSTSALTEVEMNQPQHATELMVTSDHIVPGDMAREPVEETTKSPSDVNISAQPALSNFISQLEPEVFNSLVKIMKDVQKNTVKFYIHEEEESVLCKEIKEYLIKLGNTECHPEQFLERRSKLDKLLIIIQNEDIAGFIHKIPGLVTLKKLPCVSFAGVDSLDDVKNHTYNELFVSGGFIVSDESILNPEVVTVENLKNFLTFLEELSTPEGKWQWKVHCKFQKKLKELGRLNAKALSLLTLLNVYQKKHLVEILSYHNCDSQTRNAPELDCLIRLQAQNIQQRHIVFLTEKNIKMLSSYTDNGIVVATAEDFMQNFKNLVGYHNSITEENLPQLGANENLESQSALLENDEKDEEDMSLDSGDEISHIEVCSNFHSEIWEKETKGSRGTDQKKNTQIELQSSPDVQNSLLEDKTYLDSEERTSIDIVCSEGENSNSTEQDSYSNFQVYHSQLNMSHQFSHFNVLTHQTFLGTPYALSSSQSQENENYFLSAYTESLDRDKSPPPLSWGKSDSSRPYSQEK"},{"id":"SEQ_06585","a":"Q9UBW7","g":"ZMYM2","d":"Zinc finger MYM-type protein 2","L":1377,"m":[{"c":"CxxC(x){18,23}[FLY]C[SND]xxCxxx[FYH]","u":"32-37","sp":"dispersed","x":"structured_like","cf":"high","why":"Ten zinc-coordinating cysteine-rich domain repeats across residues 331-793, each anchored by an invariant N-terminal CxxC pair and a C-terminal [FLY]C[SND]xxCxxx[FYH] motif separated by an 18-23 residue loop and connected by variable 9-33 aa linkers.","i":[[331,363,"CANCKKPLQKGQTAYQRKGSAHLFCSTTCLSSF"],[373,409,"CVMCKKDITTMKGTIVAQVDSSESFQEFCSTSCLSLY"],[425,456,"CTICGKLTEIRHEVSFKNMTHKLCSDHCFNRY"],[467,502,"CEQCGEYLPSKGAGNNVLVIDGQQKRFCCQSCVSEY"],[536,570,"CTGCRTQCRFFDMTQCIGPNGYMEPYCSTACMNSH"],[584,616,"CHFCKRNSLPQYQATMPDGKLYNFCNSSCVAKF"],[639,671,"CNYCKNSFCSKPEILEWENKVHQFCSKTCSDDY"],[681,712,"CEYCQEEKTLHETVNFSGVKRPFCSEGCKLLY"],[724,758,"CVTCNYCSQLCKKGATKELDGVVRDFCSEDCCKKF"],[768,799,"CDCCKSQGTLKERVQWRGEMKHFCDQHCLLRF"]]}],"s":"MDTSSVGGLELTDQTPVLLGSTAMATSLTNVGNSFSGPANPLVSRSNKFQNSSVEDDDDVVFIEPVQPPPPSVPVVADQRTITFTSSKNEELQGNDSKITPSSKELASQKGSVSETIVIDDEEDMETNQGQEKNSSNFIERRPPETKNRTNDVDFSTSSFSRSKVNAGMGNSGITTEPDSEIQIANVTTLETGVSSVNDGQLENTDGRDMNLMITHVTSLQNTNLGDVSNGLQSSNFGVNIQTYTPSLTSQTKTGVGPFNPGRMNVAGDVFQNGESATHHNPDSWISQSASFPRNQKQPGVDSLSPVASLPKQIFQPSVQQQPTKPVKVTCANCKKPLQKGQTAYQRKGSAHLFCSTTCLSSFSHKPAPKKLCVMCKKDITTMKGTIVAQVDSSESFQEFCSTSCLSLYEDKQNPTKGALNKSRCTICGKLTEIRHEVSFKNMTHKLCSDHCFNRYRMANGLIMNCCEQCGEYLPSKGAGNNVLVIDGQQKRFCCQSCVSEYKQVGSHPSFLKEVRDHMQDSFLMQPEKYGKLTTCTGCRTQCRFFDMTQCIGPNGYMEPYCSTACMNSHKTKYAKSQSLGIICHFCKRNSLPQYQATMPDGKLYNFCNSSCVAKFQALSMQSSPNGQFVAPSDIQLKCNYCKNSFCSKPEILEWENKVHQFCSKTCSDDYKKLHCIVTYCEYCQEEKTLHETVNFSGVKRPFCSEGCKLLYKQDFARRLGLRCVTCNYCSQLCKKGATKELDGVVRDFCSEDCCKKFQDWYYKAARCDCCKSQGTLKERVQWRGEMKHFCDQHCLLRFYCQQNEPNMTTQKGPENLHYDQGCQTSRTKMTGSAPPPSPTPNKEMKNKAVLCKPLTMTKATYCKPHMQTKSCQTDDTWRTEYVPVPIPVPVYIPVPMHMYSQNIPVPTTVPVPVPVPVFLPAPLDSSEKIPAAIEELKSKVSSDALDTELLTMTDMMSEDEGKTETTNINSVIIETDIIGSDLLKNSDPETQSSMPDVPYEPDLDIEIDFPRAAEELDMENEFLLPPVFGEEYEEQPRPRSKKKGAKRKAVSGYQSHDDSSDNSECSFPFKYTYGVNAWKHWVKTRQLDEDLLVLDELKSSKSVKLKEDLLSHTTAELNYGLAHFVNEIRRPNGENYAPDSIYYLCLGIQEYLCGSNRKDNIFIDPGYQTFEQELNKILRSWQPSILPDGSIFSRVEEDYLWRIKQLGSHSPVALLNTLFYFNTKYFGLKTVEQHLRLSFGTVFRHWKKNPLTMENKACLRYQVSSLCGTDNEDKITTGKRKHEDDEPVFEQIENTANPSRCPVKMFECYLSKSPQNLNQRMDVFYLQPECSSSTDSPVWYTSTSLDRNTLENMLVRVLLVKDIYDKDNYELDEDTD"},{"id":"SEQ_06599","a":"Q9Y566","g":"SHANK1","d":"SH3 and multiple ankyrin repeat domains protein 1","L":2161,"m":[{"c":"Gxxxφxxx[ACV]xx(x){8,9}[LT][LI]xx[GR](x){9,10}","u":"33-34","sp":"tandem","x":"structured_like","cf":"high","why":"Seven contiguous head-to-tail 33-34 aa structured repeats (residues 179-412) anchored by an invariant N-terminal G, conserved hydrophobic/small helical core positions (including GxT[PA]LxxAA across internal copies and a conserved [LT][LI] dyad), and a [GR]-initiated turn.","i":[[179,212,"GLKKFLEYVQLGTSDKVARLLDKGLDPNYHDSDS"],[213,246,"GETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARD"],[247,279,"GMTALHKAACARHCLALTALLDLGGSPNYKDRR"],[280,313,"GLTPLFHTAMVGGDPRCCELLLFNRAQLGIADEN"],[314,346,"GWQEIHQACQRGHSQHLEHLLFYGAEPGAQNAS"],[347,379,"GNTALHICALYNKETCARILLYRGADKDVKNNN"],[380,412,"GQTPFQVAVIAGNFELGELIRNHREQDVVPFQE"]]}],"s":"MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPRGTRGQGSGAPGSLASVRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRFNPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGLKKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLGGSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKETCARILLYRGADKDVKNNNGQTPFQVAVIAGNFELGELIRNHREQDVVPFQESPKYAARRRGPPGTGLTVPPALLRANSDTSMALPDWMVFSAPGAASSGAPGPTSGSQGQSQPSAPTTKLSSGTLRSASSPRGARARSPSRGRHPEDAKRQPRGRPSSSGTPREGPAGGTGGSGGPGGSLGSRGRRRKLYSAVPGRSFMAVKSYQAQAEGEISLSKGEKIKVLSIGEGGFWEGQVKGRVGWFPSDCLEEVANRSQESKQESRSDKAKRLFRHYTVGSYDSFDAPSLMDGIGPGSDYIIKEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDEAVHKKAPQQAKRLPPPTISLRSKSMTSELEEMEYEQQPAPVPSMEKKRTVYQMALNKLDEILAAAQQTISASESPGPGGLASLGKHRPKGFFATESSFDPHHRAQPSYERPSFLPPGPGLMLRQKSIGAAEDDRPYLAPPAMKFSRSLSVPGSEDIPPPPTTSPPEPPYSTPPVPSSSGRLTPSPRGGPFNPGSGGPLPASSPASFDGPSPPDTRVGSREKSLYHSGPLPPAHHHPPHHHHHHAPPPQPHHHHAHPPHPPEMETGGSPDDPPPRLALGPQPSLRGWRGGGPSPTPGAPSPSHHGSAGGGGGSSQGPALRYFQLPPRAASAAMYVPARSGRGRKGPLVKQTKVEGEPQKGGGLPPAPSPTSPASPQPPPAVAAPSEKNSIPIPTIIIKAPSTSSSGRSSQGSSTEAEPPTQPEPTGGGGGGGSSPSPAPAMSPVPPSPSPVPTPASPSGPATLDFTSQFGAALVGAARREGGWQNEARRRSTLFLSTDAGDEDGGDGGLGTGAAPGPRLRHSKSIDEGMFSAEPYLRLESAGSGAGYGGYGAGSRAYGGGGGSSAFTSFLPPRPLVHPLTGKALDPASPLGLALAARERALKESSEGGGAPQPPPRPPSPRYEAPPPTPHHHSPHAHHEPVLRLWGASPPDPARRELGYRAGLGSQEKSLPASPPAARRSLLHRLPPTAPGVGPLLLQLGTEPPAPHPGVSKPWRSAAPEEPERLPLHVRFLENCQPRAPVTSGRGPPSEDGPGVPPPSPRRSVPPSPTSPRASEENGLPLLVLPPPAPSVDVEDGEFLFVEPLPPPLEFSNSFEKPESPLTPGPPHPLPDTPAPATPLPPVPPPAVAAAPPTLDSTASSLTSYDSEVATLTQGASAAPGDPHPPGPPAPAAPAPAAPQPGPDPPPGTDSGIEEVDSRSSSDHPLETISSASTLSSLSAEGGGSAGGGGGAGAGVASGPELLDTYVAYLDGQAFGGSSTPGPPYPPQLMTPSKLRGRALGASGGLRPGPSGGLRDPVTPTSPTVSVTGAGTDGLLALRACSGPPTAGVAGGPVAVEPEVPPVPLPTASSLPRKLLPWEEGPGPPPPPLPGPLAQPQASALATVKASIISELSSKLQQFGGSSAAGGALPWARGGSGGGGDSHHGGASYVPERTSSLQRQRLSDDSQSSLLSKPVSSLFQNWPKPPLPPLPTGTGVSPTAAAAPGATSPSASSSSTSTRHLQGVEFEMRPPLLRRAPSPSLLPASEHKVSPAPRPSSLPILPSGPLYPGLFDIRGSPTGGAGGSADPFAPVFVPPHPGISGGLGGALSGASRSLSPTRLLSLPPDKPFGAKPLGFWTKFDVADWLEWLGLAEHRAQFLDHEIDGSHLPALTKEDYVDLGVTRVGHRMNIDRALKFFLER"},{"id":"SEQ_06610","a":"Q9H158","g":"PCDHAC1","d":"Protocadherin alpha-C1","L":963,"m":[{"c":"xxφxφ(x){1,4}P(x){4,5}Gxxφxxφx(x){0,2}-x-x[GS]xN[GA]xφoΩxφ(x){23,28}x-RE(x){6,8}ψxφxAxDxGxPPxS(x){2,4}φxψxψxDxNDNxPxφ","u":"102-108","sp":"tandem","x":"structured_like","cf":"high","why":"Six tandem 102-108 aa structured repeats spanning residues 22-664, anchored by conserved N-terminal P(x){4,5}G, internal acidic -x-x[GS]xN[GA]xφoΩxφ and DRE motifs, and C-terminal AxDxGxPPxS and DxNDNxPxφ motifs (degenerated at the DxNDN position in the sixth copy).","i":[[22,125,"LEYSVPEETERGVAVGNLSADLRLPAAAMSSRNFRFLSSHRELYFGVDLPSGNLVVREPADREQLCRAKAACVLTYDLVLEDPLELHKIRIHVLDTNDNSPLFP"],[128,234,"DVQLHIPEFLTPGARFTLPNAQDDDEGSNGILSYSLSPSQHFRLDMGSRVDGSEYPELVLEKALDREQRATHLLVLTARDGGLPARSGDAQVTIIVVDTNDNAPVFE"],[235,341,"RSVYRTKVPETAPNGTVLFRVQALDPDEGSNGEVQYSLSNSTQAELRHRFHVHPKSGEVQVAASLGPPETLLEAYIEARDEGVFGLASTAKLLVEVTDVNDHAPELD"],[342,446,"FLTLSNPVPEDAAPGTVIALFSVKDEDLDSNGRVICGMSSAGPFQLTASFDNYYSLLIDGPLDREQISEYQVLITASDSGSPPLSTRRTITVSVADVNDNTPNFP"],[449,556,"QQELFVAENNGPGASLGRVFAQDPDLGKNGLVSYELLDVISEGPSASSLLAVESSSGAITAKTSFDFEQLRGFHFQVEGRDGGIPPRSATVTINLFVVDRNDNYPVIL"],[563,664,"GSVPVEIVPRSARTGHLVTKVVAEDADSGSNAWLSYHISRASDSSLFRISANIGELRTARLVLPTDAVKQRVVVVVRDHGDPPLSSSVTLGVLLSNSVPQLL"]]}],"s":"MVGCGVAVLCLWVSCGAAAGQLEYSVPEETERGVAVGNLSADLRLPAAAMSSRNFRFLSSHRELYFGVDLPSGNLVVREPADREQLCRAKAACVLTYDLVLEDPLELHKIRIHVLDTNDNSPLFPAGDVQLHIPEFLTPGARFTLPNAQDDDEGSNGILSYSLSPSQHFRLDMGSRVDGSEYPELVLEKALDREQRATHLLVLTARDGGLPARSGDAQVTIIVVDTNDNAPVFERSVYRTKVPETAPNGTVLFRVQALDPDEGSNGEVQYSLSNSTQAELRHRFHVHPKSGEVQVAASLGPPETLLEAYIEARDEGVFGLASTAKLLVEVTDVNDHAPELDFLTLSNPVPEDAAPGTVIALFSVKDEDLDSNGRVICGMSSAGPFQLTASFDNYYSLLIDGPLDREQISEYQVLITASDSGSPPLSTRRTITVSVADVNDNTPNFPQPQQELFVAENNGPGASLGRVFAQDPDLGKNGLVSYELLDVISEGPSASSLLAVESSSGAITAKTSFDFEQLRGFHFQVEGRDGGIPPRSATVTINLFVVDRNDNYPVILFPLPRNGSVPVEIVPRSARTGHLVTKVVAEDADSGSNAWLSYHISRASDSSLFRISANIGELRTARLVLPTDAVKQRVVVVVRDHGDPPLSSSVTLGVLLSNSVPQLLPDFEDVWEPGGQLSAQNLYLVIALACISFLFLGCLLFFVCTKLHQSPGCCAQSCCRSTEDLRYGSKMVSNPCMTSATIDVTTVERLSQTYLYRASLGLGSDNNSLLLRGEYNAADLRNLATGVGLNLPISCIQIRNRKGDHANVNAMPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ"},{"id":"SEQ_06611","a":"Q8IV63","g":"VRK3","d":"Serine/threonine-protein kinase VRK3","L":474,"m":[{"c":"SPQx[TL][RKS]x","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Five head-to-tail 7-residue repeats in a central polar/basic disordered region anchored by an invariant SPQ tripeptide followed by conserved [TL] at position 5 and basic/polar [RKS] at position 6.","i":[[108,114,"SPQKTRK"],[115,121,"SPQVTRG"],[122,128,"SPQKTSC"],[129,135,"SPQKTRQ"],[136,142,"SPQTLKR"]]}],"s":"MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSKRGLNSSFETSPKKVKWSSTVTSPRLSLFSDGDSSESEDTLSSSERSKGSGSRPPTPKSSPQKTRKSPQVTRGSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQKFSLKLDAKDGRLFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLRVSPYDPIGLPMVP"},{"id":"SEQ_06616","a":"Q9ULU4","g":"ZMYND8","d":"MYND-type zinc finger-containing chromatin reader ZMYND8","L":1186,"m":[{"c":"E[LV]CPxxYxAxC(x){5,10}WFC[PE][PE]C","u":"22-27","sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 22-27 aa cysteine-rich structured modules separated by ~122 residues, sharing ten fixed anchors (E, four cysteines, P, Y, A, W, F), an aliphatic [LV] position, and a C-terminal WFC[PE][PE]C motif across a short variable-length loop.","i":[[104,130,"ELCPRVYHAKCLRLTSEPEGDWFCPEC"],[253,274,"EVCPECYLAACQKRDNWFCEPC"]]},{"c":"[TP]LV[TS]S[TSV]","u":6,"sp":"periodic","x":"disordered_like","cf":"medium","why":"Three regularly spaced 6-residue repeats separated by 3-4 aa polar linkers in a Ser/Thr-rich disordered region otherwise depleted of leucine, anchored by an invariant hydrophobic LV dipeptide flanked by [TP] and [TS]S[TSV].","i":[[885,890,"TLVTST"],[894,899,"PLVTSS"],[904,909,"TLVSSV"]]}],"s":"MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSELRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQGSDHSRSNKSSWSSSDEKRGSTRSDHNTSTSTKSLLPKESRLDTFWD"},{"id":"SEQ_06623","a":"A4UGR9","g":"XIRP2","d":"Xin actin-binding repeat-containing protein 2","L":3374,"m":[{"c":"G[DN]ψxxx+Ωψ[FL]E[TN]QPψ-xψx(x){1,18}E-ψx[KRG]","u":"25-42","sp":"tandem","x":"structured_like","cf":"high","why":"Head-to-tail tandem array of 42 contiguous 25-42 aa repeats anchored by an N-terminal G[DN]ψ motif, a conserved central hydrophobic/aromatic core (canonically WLFETQPLDSIx in the first 28 copies and [FL]/LL variants in the C-terminal 14 copies), and a C-terminal acidic-aliphatic E-ψx[KRG] motif.","i":[[362,396,"ADVQQARYVFENTNDSSQKDLNSEREYLEWDEILK"],[397,436,"GEVQSIRWIFENQPLDSINNGSPDEGDISRGIADQEIIAG"],[437,473,"GDVKYTTWMFETQPIDTLGAYSSDTVENAEKIPELAR"],[474,511,"GDVCTARWMFETRPLDSMNKMHQSQEESAVTISKDITG"],[512,551,"GDVKTVRYMFETQHLDQLGQLHSVDEVHLLQLRSELKEIK"],[552,589,"GNVKRSIKCFETQPLYVIRDGSGQMLEIKTVHREDVEK"],[590,627,"GDVRTARWMFETQPLDTINKDITEIKVVRGISMEENVK"],[628,660,"GGVSKAKWLFETQPLEKIKESEEVIIEKEKIIG"],[661,694,"TDVSRKCWMFETQPLDILKEVPDADSLQREEIIG"],[695,731,"GDVQTTKHLFETLPIEALKDSPDIGKLQKITASEEEK"],[732,767,"GDVRHQKWIFETQPLEDIRKDKKEYTRTVKLEEVDR"],[768,798,"GDVKNYTHIFESNNLIKFDASHKIEVEGVTR"],[799,836,"GAVELNKSLFETTPLYAIQDPLGKYHQVKTVQQEEIVR"],[837,874,"GDVRSCRWLFETRPIDQFDESIHKFQIIRGISAQEIQT"],[875,913,"GNVKSAKWLFETQPLDSIKYFSDVEETESKTEQTRDIVK"],[914,946,"GDVKTCKWLFETQPMESLYEKVSLMTSSEEIHK"],[947,984,"GDVKTCTWLFETQPLDTIKDDSETAVKLQTVKQEEIQG"],[985,1019,"GDVRTACFLFETENLDSIQGEEVKEIKPVEMDIQA"],[1020,1058,"GDVSSMRYKFENQSLDSISSSSEEVLKKIKTLKTEDIQK"],[1059,1094,"GNVLNCRWLFENQPIDKIKESQEGDECVKTVTDIQG"],[1095,1131,"GDVRKGCFIFETFSLDEIKEESDYISTKKTITEEVIQ"],[1132,1169,"GDVKSYRMLFETQPLYAIQDREGSYHEVTTVKKEEVIH"],[1170,1206,"GDVRGTRWLFETKPLDSINKSETVYVIKSVTQEDIQK"],[1207,1240,"GDVSSVRYRFETQPLDQISEESHNIMPSIDHIQG"],[1241,1271,"GNVKTSRQFFESENFDKNNYIRTVSVNEIQK"],[1272,1309,"GNVKTSTWLFETHTMDELRGEGLEYENIKTVTQEDVQK"],[1310,1344,"GDVKQAVWLFENRTFDSIMEAHKGITKMTKEEIPP"],[1345,1374,"SDVKTTTWLFETTPLHEFNETRVEKIEIIG"],[1375,1402,"KSIKETLEDLYSQKVIQAPGIIIEADEI"],[1403,1427,"GDVRMAKYKLMNQASPEIQKEEIIR"],[1428,1455,"ADLRNIMVNLLSKRDCTEREILISEEEK"],[1456,1481,"GNVNLTKTQLLNRSTEFHAEKEEIVK"],[1482,1509,"GDVQQAIKNLFSEERSVKKGILIQEDEK"],[1510,1535,"GDINMTIYCLLHENDGDTIEREEVIG"],[1536,1565,"GDVKRTIHNLLSSTSNNKISERAKIDASER"],[1566,1607,"GNVQFFTTCIEAGALDYLKQLHTESNETLTAKKQEGEKEIIG"],[1608,1635,"GDVEGTKLLLKKRQSLVERTVSETDIIP"],[1636,1663,"GDVHNTVKVFMTEPQSTFGKIPKEEIIK"],[1664,1690,"GDLTSTLNSLSQAVNQKTVTKTEEIIK"],[1691,1717,"GNMLATLKSLKESSHRWKESKQPDAIP"],[1718,1744,"GDIEKAIECLEKATNTKTEILKKELLK"],[1745,1771,"DDLETSLRSLKEAQRSFKEVHKEGVIK"]]}],"s":"MSPESGHSRIFEATAGPNKPESGFAEDSAARGEGVSDLHEVVSLKERMARYQAAVSRGDCRSFSANMMEESEMCAVPGGLAKVKKQFEDEITSSRNTFAQYQYQHQNRSEQEAIHSSQVGTSRSSQEMARNEQEGSKVQKIDVHGTEMVSHLEKHTEEVNQASQFHQYVQETVIDTPEDEEIPKVSTKLLKEQFEKSAQEKILYSDKEMTTPAKQIKTESEYEETFKPSSVVSTSSTSCVSTSQRKETSTTRYSDHSVTSSTLAQINATSSGMTEEFPPPPPDVLQTSVDVTAFSQSPELPSPPRRLPVPKDVYSKQRNLYELNRLYKHIHPELRKNLEKDYISEVSEIVSSQMNSGSSVSADVQQARYVFENTNDSSQKDLNSEREYLEWDEILKGEVQSIRWIFENQPLDSINNGSPDEGDISRGIADQEIIAGGDVKYTTWMFETQPIDTLGAYSSDTVENAEKIPELARGDVCTARWMFETRPLDSMNKMHQSQEESAVTISKDITGGDVKTVRYMFETQHLDQLGQLHSVDEVHLLQLRSELKEIKGNVKRSIKCFETQPLYVIRDGSGQMLEIKTVHREDVEKGDVRTARWMFETQPLDTINKDITEIKVVRGISMEENVKGGVSKAKWLFETQPLEKIKESEEVIIEKEKIIGTDVSRKCWMFETQPLDILKEVPDADSLQREEIIGGDVQTTKHLFETLPIEALKDSPDIGKLQKITASEEEKGDVRHQKWIFETQPLEDIRKDKKEYTRTVKLEEVDRGDVKNYTHIFESNNLIKFDASHKIEVEGVTRGAVELNKSLFETTPLYAIQDPLGKYHQVKTVQQEEIVRGDVRSCRWLFETRPIDQFDESIHKFQIIRGISAQEIQTGNVKSAKWLFETQPLDSIKYFSDVEETESKTEQTRDIVKGDVKTCKWLFETQPMESLYEKVSLMTSSEEIHKGDVKTCTWLFETQPLDTIKDDSETAVKLQTVKQEEIQGGDVRTACFLFETENLDSIQGEEVKEIKPVEMDIQAGDVSSMRYKFENQSLDSISSSSEEVLKKIKTLKTEDIQKGNVLNCRWLFENQPIDKIKESQEGDECVKTVTDIQGGDVRKGCFIFETFSLDEIKEESDYISTKKTITEEVIQGDVKSYRMLFETQPLYAIQDREGSYHEVTTVKKEEVIHGDVRGTRWLFETKPLDSINKSETVYVIKSVTQEDIQKGDVSSVRYRFETQPLDQISEESHNIMPSIDHIQGGNVKTSRQFFESENFDKNNYIRTVSVNEIQKGNVKTSTWLFETHTMDELRGEGLEYENIKTVTQEDVQKGDVKQAVWLFENRTFDSIMEAHKGITKMTKEEIPPSDVKTTTWLFETTPLHEFNETRVEKIEIIGKSIKETLEDLYSQKVIQAPGIIIEADEIGDVRMAKYKLMNQASPEIQKEEIIRADLRNIMVNLLSKRDCTEREILISEEEKGNVNLTKTQLLNRSTEFHAEKEEIVKGDVQQAIKNLFSEERSVKKGILIQEDEKGDINMTIYCLLHENDGDTIEREEVIGGDVKRTIHNLLSSTSNNKISERAKIDASERGNVQFFTTCIEAGALDYLKQLHTESNETLTAKKQEGEKEIIGGDVEGTKLLLKKRQSLVERTVSETDIIPGDVHNTVKVFMTEPQSTFGKIPKEEIIKGDLTSTLNSLSQAVNQKTVTKTEEIIKGNMLATLKSLKESSHRWKESKQPDAIPGDIEKAIECLEKATNTKTEILKKELLKDDLETSLRSLKEAQRSFKEVHKEGVIKKDAKAVMAGSSGEQKTDIHQVAVQRNKNSLLQPKPGPFEPAAKWQGGADTLSQTMGKSCHGNLVEERTEVNLPKAPKGTVKIVIDREQNNDALEKSLRRLSNSHHKSNVLESGDKTGVWTDTTGEQHLRDEYMSRQLTSTVSVKNNLTTKESDRAVRELKKDDVFNSIQSAGKTVGKQQTYELRNDHQKMEGFHIKSPKKTKNIKILTDTQSSKPSPTQHPVSMPVGGTYDLSGDFQKQTLLKQETKYSNKDIKKKNINLQPMWQLLPVEQDTSNVTEMKVSEKSHNTFKATNKKRETDVHLKSQDFLMKTNTSTGLKMAMERSLNPINFNPENNVKESECPLPPPSPPPPPPSNASSEIEFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFESFPGLPLPPPPVDEKSERESSSMFLPPPPPPTPSQKPAHLLSSSAPEKHSGDFMQQYSQKEASNSQNSQAKIITGKTGVLPPPTLPKPKLPKHIKDNKNDFSPKVELATSLSDMECKITTSKDQKKVMVMTSSEHTETKQNVISKSLDERKQLSIDSANCLSHTVPGTSAPRKKQIAPLIKSHSFPESSGQQNPKPYMRKFKTPLMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQHITEVEKEMPLQKTNEEVSLSGIDSECTVVQPSPGSQSNARILGVCSDNQLSTTSPETVAAKRLHHVLAASEDKDKMKKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHLPQSKPISPNFKVKTIKLPTLDHTLNETDHSYESHKQQSEIDVQTFTKKQYLKTKKTEASTECSHKQSLAERHYQLPKKEKRVTVQLPTESIQKNQEDKLKMVPRKQREFSGSDRGKLPGSEEKNQGPSMIGRKEERLITERKHEHLKNKSAPKVVKQKVIDAHLDSQTQNFQQTQIQTAESKAEHKKLPQPYNSLQEEKCLEVKGIQEKQVFSNTKDSKQEITQNKSFFSSVKESQRDDGKGALNIVEFLRKREELQQILSRVKQFEAEPNKSGLKTFQTLLNTIPGWLISEDKREYAVHIAMENNLEKVKEEITHIKTQAEDMLVSYENIIQTAMMSSKTGKPGNKPTSLDETSSKVSNVHVSNNKNSEQKENKIAKEKTVQHQVAAHHEATVRSHVKTHQEIKLDDSNIPPPSLKTRPPSPTFITIESTARRTENPTKNELSQSPKKDSYVEPPPRRPMSQKSEIHRANTSPSPPRSRSEQLVRLKDTTAKLSKGAIPCPAATPVPIVEKRSEIIMSPATLRRQIKIETRGRDSPPTITIPVNINHAASGSFRESVDAQEEIRKVEKRATYVHKDGLNSTDHMVPDTESYDAVEIIRKVAVPPRLSEHTQRYEAANRTVQMAENFVNDPENEINRWFREFEHGPVSEAKSNRRVYAKGETNHNIQQESRTFCKEEFGLTSLGNTSFTDFSCKHPRELREKIPVKQPRICSETRSLSEHFSGMDAFESQIVESKMKTSSSHSSEAGKSGCDFKHAPPTYEDVIAGHILDISDSPKEVRKNFQKTWQESGRVFKGLGYATADASATEMRTTFQEESAFISEAAAPRQGNMYTLSKDSLSNGVPSGRQAEFS"},{"id":"SEQ_06651","a":"Q8N8I6","g":"LINC00482","d":"Putative uncharacterized protein encoded by LINC00482","L":264,"m":[{"c":"[GQ][PR]W[TY]R[AR]A","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 7-residue copies in P/G/R/A-rich disordered-like segments anchored by invariant W3, R5, and A7, with each remaining position conserved in two of three copies ([GQ]1, [PR]2, hydroxyl-bearing [TY]4, and [AR]6).","i":[[24,30,"QPWYRAA"],[124,130,"GRWTRRA"],[203,209,"GPWTRAA"]]}],"s":"MPRSLKRAQLRSLLPRPPAVSHTQPWYRAAHPTTSPTAASRDVHPASGAVPGPWLVEGTAVREGPQLQDAVPQRPTRPSKALWPAQMSAAPAIRLGQMVPGDTRGLWGPQGTLLTWTYRGGQGGRWTRRAEGPREGTFAEQRPHFQSSGAQQESRLAMGPPPLGLGDAAGDGRGQTGQEKGRAEGRQARKSACKCPRKGPNPGPWTRAAAWWGRLEGAKASAKGEQVRDPGGHLWEQGHVSPCARFNQGHSCGSPKVSHTTWVS"},{"id":"SEQ_06656","a":"Q9C0C2","g":"CNOT12","d":"CCR4-NOT transcription complex subunit 12","L":1729,"m":[{"c":"[QR][DEA][AV]xx[QG][DEG][WQ]-[FL][GRQ]K[RS][DA](x){2,3}[GR]xY[SAG]S","u":"21-22","sp":"tandem","x":"disordered_like","cf":"high","why":"Six head-to-tail 21-22 aa repeats in a polar/charged region anchored by invariant K, Y, and C-terminal S alongside conserved [WQ]-[FL]xK[RS][DA] and [GR]xY[SAG]S cores, with a 1-residue internal insertion in copy 5.","i":[[837,857,"QEADVQDWEFRKRDSQGTYSS"],[858,878,"RDAELQDQEFGKRDSLGTYSS"],[879,899,"RDVSLGDWEFGKRDSLGAYAS"],[900,920,"QDANEQGQDLGKRDHHGRYSS"],[921,942,"QDADEQDWEFQKRDVSLGTYGS"],[943,963,"RAAEPQEQEFGKSAWIRDYSS"]]},{"c":"[GAT][VA]G[QES]x[DG]W[TSG]xx[LVE]xxxxxx","u":17,"sp":"dispersed","x":"mixed","cf":"high","why":"Seven clustered 17 aa repeats separated by 4-18 aa G/S-rich linkers, anchored by invariant G and W positions within a conserved GVGQxDW[TSG] motif followed by an LGLRxxE-like segment.","i":[[1155,1171,"TAGSVDWTDQLGLRNLE"],[1188,1204,"AVGQMGWSGGLSLRDMN"],[1221,1237,"GVGEKDWTSDVNVKSKD"],[1254,1270,"GVGQTDWSGVEAGEFLK"],[1275,1291,"GVGQADWTPDLGLRNMA"],[1305,1321,"GVGQMDWGNNLGLRDLE"],[1338,1354,"GVGQMDWTQDLAPQNVE"]]}],"s":"MKVSTLRESSAMASPLPREMEEELVPTGSEPGDTRAKPPVKPKPRALPAKPALPAKPSLLVPVGPRPPRGPLAELPSARKMNMLAGPQPYGGSKRPLPFAPRPAVEASTGGEATQETGKEEAGKEEPPPLTPPARCAAPGGVRKAPAPFRPASERFAATTVEEILAKMEQPRKEVLASPDRLWGSRLTFNHDGSSRYGPRTYGTTTAPRDEDGSTLFRGWSQEGPVKSPAECREEHSKTPEERSLPSDLAFNGDLAKAASSELPADISKPWIPSSPAPSSENGGPASPGLPAEASGSGPGSPHLHPPDKSSPCHSQLLEAQTPEASQASPCPAVTPSAPSAALPDEGSRHTPSPGLPAEGAPEAPRPSSPPPEVLEPHSLDQPPATSPRPLIEVGELLDLTRTFPSGGEEEAKGDAHLRPTSLVQRRFSEGVLQSPSQDQEKLGGSLAALPQGQGSQLALDRPFGAESNWSLSQSFEWTFPTRPSGLGVWRLDSPPPSPITEASEAAEAAEAGNLAVSSREEGVSQQGQGAGSAPSGSGSSWVQGDDPSMSLTQKGDGESQPQFPAVPLEPLPTTEGTPGLPLQQAEERYESQEPLAGQESPLPLATREAALPILEPVLGQEQPAAPDQPCVLFADAPEPGQALPVEEEAVTLARAETTQARTEAQDLCRASPEPPGPESSSRWLDDLLASPPPSGGGARRGAGAELKDTQSPSTCSEGLLGWSQKDLQSEFGITGDPQPSSFSPSSWCQGASQDYGLGGASPRGDPGLGERDWTSKYGQGAGEGSTREWASRCGIGQEEMEASSSQDQSKVSAPGVLTAQDRVVGKPAQLGTQRSQEADVQDWEFRKRDSQGTYSSRDAELQDQEFGKRDSLGTYSSRDVSLGDWEFGKRDSLGAYASQDANEQGQDLGKRDHHGRYSSQDADEQDWEFQKRDVSLGTYGSRAAEPQEQEFGKSAWIRDYSSGGSSRTLDAQDRSFGTRPLSSGFSPEEAQQQDEEFEKKIPSVEDSLGEGSRDAGRPGERGSGGLFSPSTAHVPDGALGQRDQSSWQNSDASQEVGGHQERQQAGAQGPGSADLEDGEMGKRGWVGEFSLSVGPQREAAFSPGQQDWSRDFCIEASERSYQFGIIGNDRVSGAGFSPSSKMEGGHFVPPGKTTAGSVDWTDQLGLRNLEVSSCVGSGGSSEARESAVGQMGWSGGLSLRDMNLTGCLESGGSEEPGGIGVGEKDWTSDVNVKSKDLAEVGEGGGHSQARESGVGQTDWSGVEAGEFLKSRERGVGQADWTPDLGLRNMAPGAVCSPGESKELGVGQMDWGNNLGLRDLEVTCDPDSGGSQGLRGCGVGQMDWTQDLAPQNVELFGAPSEAREHGVGGVSQCPEPGLRHNGSLSPGLEARDPLEARELGVGETSGPETQGEDYSSSSLEPHPADPGMETGEALSFGASPGRCPARPPPSGSQGLLEEMLAASSSKAVARRESAASGLGGLLEEEGAGAGAAQEEVLEPGRDSPPSWRPQPDGEASQTEDVDGTWGSSAARWSDQGPAQTSRRPSQGPPARSPSQDFSFIEDTEILDSAMYRSRANLGRKRGHRAPVIRPGGTLGLSEAADSDAHLFQDSTEPRASRVPSSDEEVVEEPQSRRTRMSLGTKGLKVNLFPGLSPSALKAKLRPRNRSAEEGELAESKSSQKESAVQRSKSCKVPGLGKPLTLPPKPEKSSGSEGSSPNWLQALKLKKKKV"},{"id":"SEQ_06657","a":"Q8WV48","g":"CCDC107","d":"Coiled-coil domain-containing protein 107","L":283,"m":[{"c":"x[QTE]xW[ESN]","u":5,"sp":"tandem","x":"disordered_like","cf":"high","why":"Four tightly spaced tandem 5 aa repeats (0-1 aa gaps) in a C-terminal acidic/polar disordered region anchored by an invariant W, constrained [QTE] and [ESN] flanking positions, and small/polar intervening residues.","i":[[223,227,"SQAWE"],[229,233,"PTNWS"],[234,238,"TETWN"],[240,244,"ATSWE"]]}],"s":"MAGAVSLLGVVGLLLVSALSGVLGDRANPDLRAHPGNAAHPGSGATEPRRRPPLKDQRERTRAGSLPLGALYTAAVAAFVLYKCLQGKDETAVLHEEASKQQPLQSEQQLAQLTQQLAQTEQHLNNLMAQLDPLFERVTTLAGAQQELLNMKLWTIHELLQDSKPDKDMEASEPGEGSGGESAGGGDKVSETGTFLISPHTEASRPLPEDFCLKEDEEEIGDSQAWEEPTNWSTETWNLATSWEVGRGLRRRCSQAVAKGPSHSLGWEGGTTAEGRLKQSLFS"},{"id":"SEQ_06666","a":"Q96MF2","g":"STAC3","d":"SH3 and cysteine-rich domain-containing protein 3","L":364,"m":[{"c":"[KQ]I[TV]V(x){13,14}G[ER]KVGφFP[PT][ND]Fψxxψ","u":"32-33","sp":"dispersed","x":"structured_like","cf":"medium","why":"Two C-terminal structured repeat cores separated by 27 residues share an N-terminal [KQ]I[TV]V strand and a strongly conserved 15-residue C-terminal G[ER]KVGφFP[PT][ND]Fψxxψ block with seven invariant anchors (G, K, V, G, F, P, F) and three conserved hydrophobic positions.","i":[[273,304,"KITVIDDSNEEWWRGKIGEKVGFFPPNFIIRV"],[332,364,"QIVVQKGDEAGGYVKVYTGRKVGLFPTDFLEEI"]]}],"s":"MTEKEVLESPKPSFPAETRQSGLQRLKQLLRKGSTGTKEMELPPEPQANGEAVGAGGGPIYYIYEEEEEEEEEEEEPPPEPPKLVNDKPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEMQRCFGKIPPGFHRAYSSPLYSNQQYACVKDLSAANRNDPVFETLRTGVIMANKERKKGQADKKNPVAAMMEEEPESARPEEGKPQDGNPEGDKKAEKKTPDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVTRSFVGNREIGQITLKKDQIVVQKGDEAGGYVKVYTGRKVGLFPTDFLEEI"},{"id":"SEQ_06667","a":"Q8N196","g":"SIX5","d":"Homeobox protein SIX5","L":739,"m":[{"c":"x[APS]Q[VA][VL][PTG]","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Six hexapeptide repeats in the C-terminal Pro/Ala/Ser-rich disordered region feature an invariant Q anchor followed by [VA][VL][PTG] and preceded by [APS], including a contiguous three-copy head-to-tail tandem cluster (LPQVVPT-SQVVTL-PQAVG) flanked by three dispersed copies.","i":[[425,430,"LAQVVP"],[450,455,"APQVVP"],[475,480,"LPQVVP"],[481,486,"TSQVVT"],[487,492,"LPQAVG"],[573,578,"VSQVLP"]]},{"c":"[IV][LI]ψNG","u":5,"sp":"dispersed","x":"mixed","cf":"medium","why":"Three closely spaced copies within a 27-residue Gly/Pro/Ser-flanked segment each pair a tri-aliphatic [IV][LI]ψpatch directly with an invariant NG dipeptide.","i":[[321,325,"ILVNG"],[336,340,"VLLNG"],[343,347,"VIING"]]}],"s":"MATLPAEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTLQAAEGEAAAAAGAGAGAAAAGAEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYRLLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPCKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVALQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLPDPDPEGLLLGATAGGEVDEGLEAEAKVLTQLQSVPVEEPLEL"},{"id":"SEQ_06677","a":"Q96Q04","g":"LMTK3","d":"Serine/threonine-protein kinase LMTK3","L":1460,"m":[{"c":"[VA][LAS][EV]NGx[LQ]xxPxxx-+","u":15,"sp":"tandem","x":"disordered_like","cf":"high","why":"Six head-to-tail contiguous 15-aa repeats (residues 928-1017) within the C-terminal disordered region, anchored by invariant N4, G5, and P10 positions, conserved N-terminal [VA][LAS][EV] and L7/Q7 residues, and an invariant C-terminal acidic-basic (-+) dyad.","i":[[928,942,"VLENGDQRAPGIEEK"],[943,957,"AAENGALGSPEREEK"],[958,972,"VLENGELTPPRREEK"],[973,987,"ALENGELRSPEAGEK"],[988,1002,"VLVNGGLTPPKSEDK"],[1003,1017,"VSENGGLRFPRNTER"]]}],"s":"MPAPGALILLAAVSASGCLASPAHPDGFALGRAPLAPPYAVVLISCSGLLAFIFLLLTCLCCKRGDVGFKEFENPEGEDCSGEYTPPAEETSSSQSLPDVYILPLAEVSLPMPAPQPSHSDMTTPLGLSRQHLSYLQEIGSGWFGKVILGEIFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCWRPPAQRPSASDLQLQLTYLLSERPPRPPPPPPPPRDGPFPWPWPPAHSAPRPGTLSSPFPLLDGFPGADPDDVLTVTESSRGLNLECLWEKARRGAGRGGGAPAWQPASAPPAPHANPSNPFYEALSTPSVLPVISARSPSVSSEYYIRLEEHGSPPEPLFPNDWDPLDPGVPAPQAPQAPSEVPQLVSETWASPLFPAPRPFPAQSSASGSFLLSGWDPEGRGAGETLAGDPAEVLGERGTAPWVEEEEEEEEGSSPGEDSSSLGGGPSRRGPLPCPLCSREGACSCLPLERGDAVAGWGGHPALGCPHPPEDDSSLRAERGSLADLPMAPPASAPPEFLDPLMGAAAPQYPGRGPPPAPPPPPPPPRAPADPAASPDPPSAVASPGSGLSSPGPKPGDSGYETETPFSPEGAFPGGGAAEEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLPGPREKPTFVVQVSTEQLLMSLREDVTRNLLGEKGATARETGPRKAGRGPGNREKVPGLNRDPTVLGNGKQAPSLSLPVNGVTVLENGDQRAPGIEEKAAENGALGSPEREEKVLENGELTPPRREEKALENGELRSPEAGEKVLVNGGLTPPKSEDKVSENGGLRFPRNTERPPETGPWRAPGPWEKTPESWGPAPTIGEPAPETSLERAPAPSAVVSSRNGGETAPGPLGPAPKNGTLEPGTERRAPETGGAPRAPGAGRLDLGSGGRAPVGTGTAPGGGPGSGVDAKAGWVDNTRPQPPPPPLPPPPEAQPRRLEPAPPRARPEVAPEGEPGAPDSRAGGDTALSGDGDPPKPERKGPEMPRLFLDLGPPQGNSEQIKARLSRLSLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAPGPAEEDGEDEDEDEEEDEEAAAPGAAAGPRGPGRARAAPVPVVVSSADADAARPLRGLLKSPRGADEPEDSELERKRKMVSFHGDVTVYLFDQETPTNELSVQAPPEGDTDPSTPPAPPTPPHPATPGDGFPSNDSGFGGSFEWAEDFPLLPPPGPPLCFSRFSVSPALETPGPPARAPDARPAGPVEN"},{"id":"SEQ_06680","a":"Q6P597","g":"KLC3","d":"Kinesin light chain 3","L":504,"m":[{"c":"xPxx[AL]xx[LK][NH][NI]L[AV]xx[YC]xx[QR][GN]+Ωxx[AV]xx[LH]xxx[AI]Lxxx-xxx[GP]xx","u":42,"sp":"tandem","x":"structured_like","cf":"high","why":"Five head-to-tail 42-residue structured repeats spanning residues 203-412, anchored by invariant P2, L11, L32, basic +20, aromatic Ω21, acidic -36, and strongly conserved [NH][NI]L[AV] and [AI]L helical cores.","i":[[203,244,"IPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHC"],[245,286,"HPDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPE"],[287,328,"HPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGAD"],[329,370,"HPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGPH"],[371,412,"DPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLG"]]}],"s":"MSVQVAAPGSAGLGPERLSPEELVRQTRQVVQGLEALRAEHHGLAGHLAEALAGQGPAAGLEMLEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRSQARRLAQENVWLREELEETQRRLRASEESVAQLEEEKRHLEFLGQLRQYDPPAESQQSESPPRRDSLASLFPSEEEERKGPEAAGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGAPNTGTAGDAEQALRRSSSLSKIRESIRRGSEKLVSRLRGEAAAGAAGMKRAMSLNTLNVDAPRAPGTQFPSWHLDKAPRTLSASTQDLSPH"},{"id":"SEQ_06686","a":"Q9NW75","g":"GPATCH2","d":"G patch domain-containing protein 2","L":528,"m":[{"c":"[VI]GN+x[LM]","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 6-residue motifs in disordered segments (each positioned ~13-24 aa C-terminal to a basic K/R cluster), sharing an invariant GN core flanked by aliphatic [VI] at position 1, basic + at position 4, and [LM] at position 6.","i":[[153,158,"VGNRTL"],[373,378,"VGNKRM"],[470,475,"IGNRML"]]}],"s":"MFGAAGRQPIGAPAAGNSWHFSRTMEELVHDLVSALEESSEQARGGFAETGDHSRSISCPLKRQARKRRGRKRRSYNVHHPWETGHCLSEGSDSSLEEPSKDYRENHNNNKKDHSDSDDQMLVAKRRPSSNLNNNVRGKRPLWHESDFAVDNVGNRTLRRRRKVKRMAVDLPQDISNKRTMTQPPEGCRDQDMDSDRAYQYQEFTKNKVKKRKLKIIRQGPKIQDEGVVLESEETNQTNKDKMECEEQKVSDELMSESDSSSLSSTDAGLFTNDEGRQGDDEQSDWFYEKESGGACGITGVVPWWEKEDPTELDKNVPDPVFESILTGSFPLMSHPSRRGFQARLSRLHGMSSKNIKKSGGTPTSMVPIPGPVGNKRMVHFSPDSHHHDHWFSPGARTEHDQHQLLRDNRAERGHKKNCSVRTASRQTSMHLGSLCTGDIKRRRKAAPLPGPTTAGFVGENAQPILENNIGNRMLQNMGWTPGSGLGRDGKGISEPIQAMQRPKGLGLGFPLPKSTSATTTPNAGKSA"},{"id":"SEQ_06701","a":"A7XYQ1","g":"SOBP","d":"Sine oculis-binding protein homolog","L":873,"m":[{"c":"ψψC[AD]WC[QK][KH]ψxxx+xxLxφG(x){5,7}FCS[EA]KC[FL]xxx+xxφFx+","u":"41-43","sp":"dispersed","x":"structured_like","cf":"high","why":"Strongly conserved 41-43 aa two-copy cysteine-rich domain duplication separated by a 33 aa linker, anchored by invariant CxWC and FCSxKC motifs, a conserved LxφG turn before a 5-7 aa loop, and flanking aliphatic/aromatic/basic positions.","i":[[149,189,"IMCAWCQKVGIKRYSLSMGSEVKSFCSEKCFAACRRAYFKR"],[223,265,"LVCDWCKHIRHTKEYLDFGDGERRLQFCSAKCLNQYKMDIFYK"]]}],"s":"MAEMEKEGRPPENKRSRKPAHPVKREINEEMKNFAENTMNELLGWYGYDKVELKDGEDIEFRSYPTDGESRQHISVLKENSLPKPKLPEDSVISPYNISTGYSGLATGNGLSDSPAGSKDHGSVPIIVPLIPPPFIKPPAEDDVSNVQIMCAWCQKVGIKRYSLSMGSEVKSFCSEKCFAACRRAYFKRNKARDEDGHAENFPQQHYAKETPRLAFKNNCELLVCDWCKHIRHTKEYLDFGDGERRLQFCSAKCLNQYKMDIFYKETQANLPAGLCSTLHPPMENKAEGTGVQLLTPDSWNIPLTDARRKAPSPVATAGQSQGPGPSASTTVSPSDTANCSVTKIPTPVPKSIPISETPNIPPVSVQPPASIGPPLGVPPRSPPMVMTNRGPVPLPIFMEQQIMQQIRPPFIRGPPHHASNPNSPLSNPMLPGIGPPPGGPRNLGPTSSPMHRPMLSPHIHPPSTPTMPGNPPGLLPPPPPGAPLPSLPFPPVSMMPNGPMPVPQMMNFGLPSLAPLVPPPTLLVPYPVIVPLPVPIPIPIPIPHVSDSKPPNGFSSNGENFIPNAPGDSAAAGGKPSGHSLSPRDSKQGSSKSADSPPGCSGQALSLAPTPAEHGRSEVVDLTRRAGSPPGPPGAGGQLGFPGVLQGPQDGVIDLTVGHRARLHNVIHRALHAHVKAEREPSAAERRTCGGCRDGHCSPPAAGDPGPGAPAGPEAAAACNVIVNGTRGAAAEGAKSAEPPPEQPPPPPPPAPPKKLLSPEEPAVSELESVKENNCASNCHLDGEAAKKLMGEEALAGGDKSDPNLNNPADEDHAYALRMLPKTGCVIQPVPKPAEKAAMAPCIISSPMLSAGPEDLEPPLKRRCLRIRNQNK"},{"id":"SEQ_06704","a":"Q5THR3","g":"EFCAB6","d":"EF-hand calcium-binding domain-containing protein 6","L":1501,"m":[{"c":"xφxxx[FL]xxxDxxxxGxψxxx-φxxφψxxφ(x){2,3}ψ[TS]xx[EQ]φxxφφxxφ(x){7,8}φxΩxxFψxxφxx","u":"64-65","sp":"dispersed","x":"structured_like","cf":"high","why":"13 dispersed copies of a 64-65 aa paired helix-loop-helix (EF-hand pair) domain spanning the full protein, separated by 34-84 aa linkers. Each unit pairs a canonical N-terminal 12-aa acidic/glycine loop (DxxxxGxψxxx-) with a conserved ψ[TS]xx[EQ]φxxφφ inter-motif junction and a C-terminal helix-loop-helix ending in φxΩxxFψxxφ.","i":[[74,137,"ELQKAFQLLDTGQNLTVSKSELRRIITDFLMPLTREQFQDVLAQIPLSTSGTVPYLAFLSRFGG"],[176,239,"TVMKAFELIDVNKTGLVRPQELRRVLETFCMKLRDEEYEKFSKHYNIHKDTAVDYNVFLKNLSI"],[301,364,"KVEKALSAGDPCKGGYVSFNYLKIVLDTFVYQIPRRIFIQLMKRFGLKATTKINWKQFLTSFHE"],[407,470,"SLKKALLIINTKPDGPITREEFRYILNCMAVKLSDSEFKELMQMLDPGDTGVVNTSMFIDLIEE"],[508,571,"AFYNMLRSYDLGDTGRIGRNNFKKIMHVFCPFLTNAHFIKLCSKIQDIGSGRILYKKLLACIGI"],[638,701,"AFKKRFLDFSKEPNGKINVHDFKKVLEDTGMPMDDDQYALLTTKIGFEKEGMSYLDFAAGFEDP"],[745,808,"DPYSAFFKTDADRDGIINMHDLHRLLLHLLLNLKDDEFERFLGLLGLRLSVTLNFREFQNLCEK"],[851,914,"DLSKNFLETDNEGNGILRRRDIKNALYGFDIPLTPREFEKLWARYDTEGKGHITYQEFLQKLGI"],[968,1032,"DISKAFTKTDQSKTNYISICKMQEVLEECGCSLTEGELTHLLNSWGVSRHDNAINYLDFLRAVEN"],[1073,1136,"ALSTAFSALDKEDTGFVKATEFGQVLKDFCYKLTDNQYHYFLRKLRIHLTPYINWKYFLQNFSC"],[1180,1243,"AITQEFENFDTMKTNTISREEFRAICNRRVQILTDEQFDRLWNEMPVNAKGRLKYPDFLSRFSS"],[1327,1390,"QLLKECKEKDVARQGDINASDFLALVEKFNLDISKEECQQLIIKYDLKSNGKFAYCDFIQSCVL"],[1438,1501,"PMRRTFKSYDEAGTGLLSVADFRTVLRQYSINLSEEEFFHILEYYDKTLSSKISYNDFLRAFLQ"]]}],"s":"MCKMAIIPDWLRSHPHTRKFTHSRPHSSPCRVYSRNGSPNKFRSSSTTAVANPTLSSLDVKRILFQKITDRGDELQKAFQLLDTGQNLTVSKSELRRIITDFLMPLTREQFQDVLAQIPLSTSGTVPYLAFLSRFGGIDLYINGIKRGGGNEMNCCRTLRELEIQVGEKVFKNIKTVMKAFELIDVNKTGLVRPQELRRVLETFCMKLRDEEYEKFSKHYNIHKDTAVDYNVFLKNLSINNDLNLRYCMGNQEVSLENQQAKNSKKERLLGSASSEDIWRNYSLDEIERNFCLQLSKSYEKVEKALSAGDPCKGGYVSFNYLKIVLDTFVYQIPRRIFIQLMKRFGLKATTKINWKQFLTSFHEPQGLQVSSKGPLTKRNSINSRNESHKENIITKLFRHTEDHSASLKKALLIINTKPDGPITREEFRYILNCMAVKLSDSEFKELMQMLDPGDTGVVNTSMFIDLIEENCRMRKTSPCTDAKTPFLLAWDSVEEIVHDTITRNLQAFYNMLRSYDLGDTGRIGRNNFKKIMHVFCPFLTNAHFIKLCSKIQDIGSGRILYKKLLACIGIDGPPTVSPVLVPKDQLLSEHLQKDEQQQPDLSERTKLTEDKTTLTKKMTTEEVIEKFKKCIQQQDPAFKKRFLDFSKEPNGKINVHDFKKVLEDTGMPMDDDQYALLTTKIGFEKEGMSYLDFAAGFEDPPMRGPETTPPQPPTPSKSYVNSHFITAEECLKLFPRRLKESFRDPYSAFFKTDADRDGIINMHDLHRLLLHLLLNLKDDEFERFLGLLGLRLSVTLNFREFQNLCEKRPWRTDEAPQRLIRPKQKVADSELACEQAHQYLVTKAKNRWSDLSKNFLETDNEGNGILRRRDIKNALYGFDIPLTPREFEKLWARYDTEGKGHITYQEFLQKLGINYSPAVHRPCAEDYFNFMGHFTKPQQLQEEMKELQQSTEKAVAARDKLMDRHQDISKAFTKTDQSKTNYISICKMQEVLEECGCSLTEGELTHLLNSWGVSRHDNAINYLDFLRAVENSKSTGAQPKEKEESMPINFATLNPQEAVRKIQEVVESSQLALSTAFSALDKEDTGFVKATEFGQVLKDFCYKLTDNQYHYFLRKLRIHLTPYINWKYFLQNFSCFLEETADEWAEKMPKGPPPTSPKATADRDILARLHKAVTSHYHAITQEFENFDTMKTNTISREEFRAICNRRVQILTDEQFDRLWNEMPVNAKGRLKYPDFLSRFSSETAATPMATGDSAVAQRGSSVPDVSEGTRSALSLPTQELRPGSKSQSHPCTPASTTVIPGTPPLQNCDPIESRLRKRIQGCWRQLLKECKEKDVARQGDINASDFLALVEKFNLDISKEECQQLIIKYDLKSNGKFAYCDFIQSCVLLLKAKESSLMHRMKIQNAHKMKEAGAETPSFYSALLRIQPKIVHCWRPMRRTFKSYDEAGTGLLSVADFRTVLRQYSINLSEEEFFHILEYYDKTLSSKISYNDFLRAFLQ"},{"id":"SEQ_06711","a":"Q9BU19","g":"ZNF692","d":"Zinc finger protein 692","L":519,"m":[{"c":"φxC(x){2,4}C[GA]xx[FC]xxxxxψxxH(x){3,5}H","u":"23-26","sp":"periodic","x":"structured_like","cf":"high","why":"Array of 5 C2H2-type Cys2His2 zinc finger repeats separated by regular 5-aa linkers (8 aa before the fifth copy). Copies share invariant C..C and H..H metal-coordinating anchors, an N-terminal hydrophobic residue (φxC), and conserved internal structural positions ([GA] at +1, F/C at +4, and aliphatic ψ at +10 after the second Cys).","i":[[328,353,"MPCDFPGCGRIFSNRQYLNHHKKYQH"],[359,383,"FSCPEPACGKSFNFKKHLKEHMKLH"],[389,411,"YICEFCARSFRTSSNLVIHRRIH"],[417,439,"LQCEICGFTCRQKASLNWHQRKH"],[448,471,"FPCEFCGKRFEKPDSVAAHRSKSH"]]}],"s":"MASSPAVDVSCRRREKRRQLDARRSKCRIRLGGHMEQWCLLKERLGFSLHSQLAKFLLDRYTSSGCVLCAGPEPLPPKGLQYLVLLSHAHSRECSLVPGLRGPGGQDGGLVWECSAGHTFSWGPSLSPTPSEAPKPASLPHTTRRSWCSEATSGQELADLESEHDERTQEARLPRRVGPPPETFPPPGEEEGEEEEDNDEDEEEMLSDASLWTYSSSPDDSEPDAPRLLPSPVTCTPKEGETPPAPAALSSPLAVPALSASSLSSRAPPPAEVRVQPQLSRTPQAAQQTEALASTGSQAQSAPTPAWDEDTAQIGPKRIRKAAKRELMPCDFPGCGRIFSNRQYLNHHKKYQHIHQKSFSCPEPACGKSFNFKKHLKEHMKLHSDTRDYICEFCARSFRTSSNLVIHRRIHTGEKPLQCEICGFTCRQKASLNWHQRKHAETVAALRFPCEFCGKRFEKPDSVAAHRSKSHPALLLAPQESPSGPLEPCPSISAPGPLGSSEGSRPSASPQAPTLLPQQ"},{"id":"SEQ_06718","a":"P31629","g":"HIVEP2","d":"Transcription factor HIVEP2","L":2446,"m":[{"c":"YxCxxC[SGN]x[ASR][CF][AK][KT][PK][SG]xLxKHx+[ST](x){0,2}H","u":"23-25","sp":"dispersed","x":"structured_like","cf":"high","why":"Four C2H2-like Cys2His2 repeats with invariant Y, CxxC, L, K, and HxxH/HxxxxH anchors arranged as two homologous tandem pairs (connected by 5-aa T[GD][EV]RP linkers) duplicated near the N- and C-termini.","i":[[189,211,"YICPYCSRACAKPSVLKKHIRSH"],[217,241,"YPCIPCGFSFKTKSNLYKHRKSHAH"],[1799,1821,"YICEECGIRCKKPSMLKKHIRTH"],[1827,1851,"YVCKLCNFAFKTKGNLTKHMKSKAH"]]},{"c":"[DH][LV]SP[RM]+","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Seven tightly conserved 6-aa [DH][LV]SP[RM]+ repeats (accompanied by two degenerate flanking variants PVSPGK and APSPRR) clustered as a tandem quartet, a tandem pair, and a singleton within a C-terminal disordered region.","i":[[2069,2074,"DLSPRR"],[2075,2080,"HLSPRR"],[2081,2086,"DLSPMR"],[2087,2092,"HLSPRK"],[2104,2109,"DVSPRR"],[2110,2115,"HLSPRR"],[2128,2133,"DLSPRR"]]}],"s":"MDTGDTALGQKATSRSGETDKASGRWRQEQSAVIKMSTFGSHEGQRQPQIEPEQIGNTASAQLFGSGKLASPSEVVQQVAEKQYPPHRPSPYSCQHSLSFPQHSLPQGVMHSTKPHQSLEGPPWLFPGPLPSVASEDLFPFPIHGHSGGYPRKKISSLNPAYSQYSQKSIEQAEEAHKKEHKPKKPGKYICPYCSRACAKPSVLKKHIRSHTGERPYPCIPCGFSFKTKSNLYKHRKSHAHAIKAGLVPFTESAVSKLDLEAGFIDVEAEIHSDGEQSTDTDEESSLFAEASDKMSPGPPIPLDIASRGGYHGSLEESLGGPMKVPILIIPKSGIPLPNESSQYIGPDMLPNPSLNTKADDSHTVKQKLALRLSEKKGQDSEPSLNLLSPHSKGSTDSGYFSRSESAEQQISPPNTNAKSYEEIIFGKYCRLSPRNALSVTTTSQERAAMGRKGIMEPLPHVNTRLDVKMFEDPVSQLIPSKGDVDPSQTSMLKSTKFNSESRQPQIIPSSIRNEGKLYPANFQGSNPVLLEAPVDSSPLIRSNSVPTSSATNLTIPPSLRGSHSFDERMTGSDDVFYPGTVGIPPQRMLRRQAAFELPSVQEGHVEVEHHGRMLKGISSSSLKEKKLSPGDRVGYDYDVCRKPYKKWEDSETPKQNYRDISCLSSLKHGGEYFMDPVVPLQGVPSMFGTTCENRKRRKEKSVGDEEDTPMICSSIVSTPVGIMASDYDPKLQMQEGVRSGFAMAGHENLSHGHTERFDPCRPQLQPGSPSLVSEESPSAIDSDKMSDLGGRKPPGNVISVIQHTNSLSRPNSFERSESAELVACTQDKAPSPSETCDSEISEAPVSPEWAPPGDGAESGGKPSPSQQVQQQSYHTQPRLVRQHNIQVPEIRVTEEPDKPEKEKEAQSKEPEKPVEEFQWPQRSETLSQLPAEKLPPKKKRLRLADMEHSSGESSFESTGTGLSRSPSQESNLSHSSSFSMSFEREETSKLSALPKQDEFGKHSEFLTVPAGSYSLSVPGHHHQKEMRRCSSEQMPCPHPAEVPEVRSKSFDYGNLSHAPVSGAAASTVSPSRERKKCFLVRQASFSGSPEISQGEVGMDQSVKQEQLEHLHAGLRSGWHHGPPAVLPPLQQEDPGKQVAGPCPPLSSGPLHLAQPQIMHMDSQESLRNPLIQPTSYMTSKHLPEQPHLFPHQETIPFSPIQNALFQFQYPTVCMVHLPAQQPPWWQAHFPHPFAQHPQKSYGKPSFQTEIHSSYPLEHVAEHTGKKPAEYAHTKEQTYPCYSGASGLHPKNLLPKFPSDQSSKSTETPSEQVLQEDFASANAGSLQSLPGTVVPVRIQTHVPSYGSVMYTSISQILGQNSPAIVICKVDENMTQRTLVTNAAMQGIGFNIAQVLGQHAGLEKYPIWKAPQTLPLGLESSIPLCLPSTSDSVATLGGSKRMLSPASSLELFMETKQQKRVKEEKMYGQIVEELSAVELTNSDIKKDLSRPQKPQLVRQGCASEPKDGLQSGSSSFSSLSPSSSQDYPSVSPSSREPFLPSKEMLSGSRAPLPGQKSSGPSESKESSDELDIDETASDMSMSPQSSSLPAGDGQLEEEGKGHKRPVGMLVRMASAPSGNVADSTLLLTDMADFQQILQFPSLRTTTTVSWCFLNYTKPNYVQQATFKSSVYASWCISSCNPNPSGLNTKTTLALLRSKQKITAEIYTLAAMHRPGTGKLTSSSAWKQFTQMKPDASFLFGSKLERKLVGNILKERGKGDIHGDKDIGSKQTEPIRIKIFEGGYKSNEDYVYVRGRGRGKYICEECGIRCKKPSMLKKHIRTHTDVRPYVCKLCNFAFKTKGNLTKHMKSKAHMKKCLELGVSMTSVDDTETEEAENLEDLHKAAEKHSMSSISTDHQFSDAEESDGEDGDDNDDDDEDEDDFDDQGDLTPKTRSRSTSPQPPRFSSLPVNVGAVPHGVPSDSSLGHSSLISYLVTLPSIRVTQLMTPSDSCEDTQMTEYQRLFQSKSTDSEPDKDRLDIPSCMDEECMLPSEPSSSPRDFSPSSHHSSPGYDSSPCRDNSPKRYLIPKGDLSPRRHLSPRRDLSPMRHLSPRKEAALRREMSQRDVSPRRHLSPRRPVSPGKDITARRDLSPRRERRYMTTIRAPSPRRALYHNPPLSMGQYLQAEPIVLGPPNLRRGLPQVPYFSLYGDQEGAYEHPGSSLFPEGPNDYVFSHLPLHSQQQVRAPIPMVPVGGIQMVHSMPPALSSLHPSPTLPLPMEGFEEKKGASGESFSKDPYVLSKQHEKRGPHALQSSGPPSTPSSPRLLMKQSTSEDSLNATEREQEENIQTCTKAIASLRIATEEAALLGPDQPARVQEPHQNPLGSAHVSIRHFSRPEPGQPCTSATHPDLHDGEKDNFGTSQTPLAHSTFYSKSCVDDKQLDFHSSKELSSSTEESKDPSSEKSQLH"},{"id":"SEQ_06727","a":"Q5H9T9","g":"FSCB","d":"Fibrous sheath CABYR-binding protein","L":825,"m":[{"c":"[AV]xψ[QE]P[PL]xxEE[AT][PTL]","u":12,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Ten 12-residue proline/glutamate-rich repeats in the central disordered domain, anchored by invariant P5 and E9-E10 dipeptides plus conserved aliphatic/polar positions, including six identical head-to-tail AEVQPPPAEEAP copies at residues 608-679.","i":[[267,278,"AKIQPPLVEEAT"],[314,325,"VKVQPPPAEEAP"],[410,421,"AKVEPPTVEETL"],[422,433,"ADVQPLLPEEAP"],[608,619,"AEVQPPPAEEAP"],[620,631,"AEVQPPPAEEAP"],[632,643,"AEVQPPPAEEAP"],[644,655,"AEVQPPPAEEAP"],[656,667,"AEVQPPPAEEAP"],[668,679,"AEVQPPPAEEAP"]]},{"c":"[AL][EA]φx[SP][PL][PLS][ASG]-x[TSV][PTS]x[EDV]Exx","u":17,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Ten non-overlapping 17-residue repeats arranged in three sub-arrays flanking the 12-mer tract, sharing an N-terminal AEφx[SP]P core, central acidic-polar segment, and invariant E15.","i":[[331,347,"AEIQPPSAEESPSVELL"],[348,364,"AEILPPSAEESPSEEPP"],[365,381,"AEILPPPAEKSPSVELL"],[489,505,"AEARSPLSEETSAEEAH"],[506,522,"AEVQSPLAEETTAEEAS"],[540,556,"AEAQSPLSEETSAEEAP"],[574,590,"LELQPPSGEETTAEEAS"],[680,696,"AEVQSLPAEETPIEETL"],[697,713,"AAVHSPPADDVPAEEAS"],[736,752,"AEVSPPPSEQTPEDEAL"]]},{"c":"A[EA]IQLLAA[TI]E[PA][PS]A-E[TA]P","u":17,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three highly conserved 17-residue repeats interleaved within the central repeat domain, anchored by an invariant IQLLAA hydrophobic core and C-terminal A-E[TA]P motif.","i":[[472,488,"AEIQLLAATEPPADETP"],[523,539,"AEIQLLAAIEAPADETP"],[591,607,"AAIQLLAATEASAEEAP"]]}],"s":"MVGKSQQTDVIEKKKHMAIPKSSSPKATHRIGNTSGSKGSYSAKAYESIRVSSELQQTWTKRKHGQEMTSKSLQTDTIVEEKKEVKLVEETVVPEEKSADVREAAIELPESVQDVEIPPNIPSVQLKMDRSQQTSRTGYWTMMNIPPVEKVDKEQQTYFSESEIVVISRPDSSSTKSKEDALKHKSSGKIFASEHPEFQPATNSNEEIGQKNISRTSFTQETKKGPPVLLEDELREEVTVPVVQEGSAVKKVASAEIEPPSTEKFPAKIQPPLVEEATAKAEPRPAEETHVQVQPSTEETPDAEAATAVAENSVKVQPPPAEEAPLVEFPAEIQPPSAEESPSVELLAEILPPSAEESPSEEPPAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAPAKVEPPTVEETLADVQPLLPEEAPREEARELQLSTAMETPAEEAPTEFQSPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSPLAEETTAEEASAEIQLLAAIEAPADETPAEAQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLELQPPSGEETTAEEASAAIQLLAATEASAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQSLPAEETPIEETLAAVHSPPADDVPAEEASVDKHSPPADLLLTEEFPIGEASAEVSPPPSEQTPEDEALVENVSTEFQSPQVAGIPAVKLGSVVLEGEAKFEEVSKINSVLKDLSNTNDGQAPTLEIESVFHIELKQRPPEL"},{"id":"SEQ_06753","a":"Q5VX71","g":"SUSD4","d":"Sushi domain-containing protein 4","L":490,"m":[{"c":"CxxP(x){14,20}GxxφxφxCx[DEP]GΩ[KS]ψ(x){7,11}C(x){4,9}W(x){5,7}C","u":"56-61","sp":"periodic","x":"structured_like","cf":"high","why":"Four ~56-61 aa cysteine-rich structured repeats separated by short 2-5 aa linkers, each anchored by four conserved cysteines, an N-terminal CxxP motif, an internal GxxφxφxCx[DEP]GΩ[KS]ψ core, and a conserved tryptophan before the terminal cysteine.","i":[[57,117,"CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSIC"],[122,177,"CRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPIC"],[180,237,"CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRC"],[243,302,"CPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQVYC"]]}],"s":"MYHGMNPSNGDGFLEQQQQQQQPQSPQRLLAVILWFQLALCFGPAQLTGGFDDLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQVYCIKSEQTWPSTHETLLTTWKIVAFTATSVLLVLLLVILARMFQTKFKAHFPPRGPPRSSSSDPDFVVVDGVPVMLPSYDEAVSGGLSALGPGYMASVGQGCPLPVDDQSPPAYPGSGDTDTGPGESETCDSVSGSSELLQSLYSPPRCQESTHPASDNPDIIASTAEEVASTSPGIDIADEIPLMEEDP"},{"id":"SEQ_06756","a":"O75022","g":"LILRB3","d":"Leukocyte immunoglobulin-like receptor subfamily B member 3","L":631,"m":[{"c":"(x){3,4}[KT][PV][TS]Lxxxx[GS][PS][VT]ψ[SA]xGxxψTψxC[QG][GS]xx[EGQ]φxxΩxLxKEG(x){18,21}F[SPT]ψ[PSG][SP]ψ[TS][EPS][HSA][HN]x[GW]xΩ[RT]C[HY](x){6,9}[WL]S[EHA]PS-PL[EN]ψψ[MPV][TSA]G","u":"96-101","sp":"tandem","x":"structured_like","cf":"high","why":"Four head-to-tail 96-101 aa structured repeats (zero-residue gaps) sharing two conserved cysteines, fixed G/T/L/KEG/F anchors, aromatic-basic motifs before the second cysteine, and a C-terminal [WL]S[EHA]PS-PL[EN]ψψxxG signature.","i":[[24,119,"GPFPKPTLWAEPGSVISWGSPVTIWCQGSQEAQEYRLHKEGSPEPLDRNNPLEPKNKARFSIPSMTEHHAGRYRCHYYSSAGWSEPSDPLEMVMTG"],[120,220,"AYSKPTLSALPSPVVASGGNMTLRCGSQKGYHHFVLMKEGEHQLPRTLDSQQLHSRGFQALFPVGPVTPSHRWRFTCYYYYTNTPWVWSHPSDPLEILPSG"],[221,319,"VSRKPSLLTLQGPVLAPGQSLTLQCGSDVGYNRFVLYKEGERDFLQRPGQQPQAGLSQANFTLGPVSPSNGGQYRCYGAHNLSSEWSAPSDPLNILMAG"],[320,420,"QIYDTVSLSAQPGPTVASGENVTLLCQSWWQFDTFLLTKEGAAHPPLRLRSMYGAHKYQAEFPMSPVTSAHAGTYRCYGSYSSNPHLLSHPSEPLELVVSG"]]},{"c":"[EQ]x[NVS][LTI]YAx[VL]","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed 8-aa motifs in the C-terminal disordered region anchored by an invariant YA dipeptide, a conserved C-terminal aliphatic [VL] at +3, a constrained [LTI] position at -1, and an N-terminal [EQ] anchor.","i":[[510,517,"EENLYAAV"],[539,546,"QAVTYAPV"],[591,598,"QDVTYAQL"],[621,628,"EPSIYATL"]]}],"s":"MTPALTALLCLGLSLGPRTRVQAGPFPKPTLWAEPGSVISWGSPVTIWCQGSQEAQEYRLHKEGSPEPLDRNNPLEPKNKARFSIPSMTEHHAGRYRCHYYSSAGWSEPSDPLEMVMTGAYSKPTLSALPSPVVASGGNMTLRCGSQKGYHHFVLMKEGEHQLPRTLDSQQLHSRGFQALFPVGPVTPSHRWRFTCYYYYTNTPWVWSHPSDPLEILPSGVSRKPSLLTLQGPVLAPGQSLTLQCGSDVGYNRFVLYKEGERDFLQRPGQQPQAGLSQANFTLGPVSPSNGGQYRCYGAHNLSSEWSAPSDPLNILMAGQIYDTVSLSAQPGPTVASGENVTLLCQSWWQFDTFLLTKEGAAHPPLRLRSMYGAHKYQAEFPMSPVTSAHAGTYRCYGSYSSNPHLLSHPSEPLELVVSGHSGGSSLPPTGPPSTPGLGRYLEVLIGVSVAFVLLLFLLLFLLLRRQRHSKHRTSDQRKTDFQRPAGAAETEPKDRGLLRRSSPAADVQEENLYAAVKDTQSEDRVELDSQSPHDEDPQAVTYAPVKHSSPRREMASPPSSLSGEFLDTKDRQVEEDRQMDTEAAASEASQDVTYAQLHSLTLRRKATEPPPSQEGEPPAEPSIYATLAIH"},{"id":"SEQ_06763","a":"P63130","g":"ERVK-7","d":"Endogenous retrovirus group K member 7 Gag polyprotein","L":666,"m":[{"c":"PPx[AE]xQY","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three tandem 7-aa repeats separated by 1-aa linkers in the central proline/glutamine-rich disordered linker, anchored by an N-terminal PP dipeptide, an internal [AE] choice, and a C-terminal QY dipeptide.","i":[[206,212,"PPVAYQY"],[214,220,"PPAELQY"],[222,228,"PPPESQY"]]}],"s":"MGQTKSKIKSKYASYLSFIKILLKRGGVKVSTKNLIKLFQIIEQFCPWFPEQGTLDLKDWKRIGKELKQAGRKGNIIPLTVWNDWAIIKAALEPFQTEKDSVSVSDALGSCIIDCNENTRKKSQKETEGLHCEYVAEPVMAQSTQNVDYNQLQEVIYPETLKLEGKGPELVGPSESKPRGTSHLPAGQVPVTLQPQKQVKENKTQPPVAYQYWPPAELQYRPPPESQYGYPGMPPAPQGRAPYPQPPTRRLNPTAPPSRQGSELHEIIDKSRKEGDTEAWQFPVTLEPMPPGEGAQEGEPPTVEARYKSFSIKMLKDMKEGVKQYGPNSPYMRTLLDSIAHGHRLIPYDWEILAKSSLSPSQFLQFKTWWIDGVQEQVRRNRAANPPVNIDADQLLGIGQNWSTISQQALMQNEAIEQVRAICLRAWEKIQDPGSTCPSFNTVRQGSKEPYPDFVARLQDVAQKSIADEKARKVIVELMAYENANPECQSAIKPLKGKVPAGSDVISEYVKACDGIGGAMHKAMLMAQAITGVVLGGQVRTFGGKCYNCGQIGHLKKNCPVLNKQNITIQATTTGREPPDLCPRCKKGKHWASQCRSKFDKNGQPLSGNEQRGQPQAPQQTGAFPIQPFVPQGFQEQQPPLSQVFQGISQLPQYNNCPPPQAAVQQ"},{"id":"SEQ_06769","a":"Q5JTC6","g":"AMER1","d":"APC membrane recruitment protein 1","L":1135,"m":[{"c":"E[ATV]xx[RW]","u":5,"sp":"tandem","x":"mixed","cf":"high","why":"13-copy head-to-tail tandem 5-mer array (residues 582-646) anchored by an invariant N-terminal Glu (13/13), a conserved C-terminal Arg (12/13, with one Trp substitution), and Ala/Thr/Val at position 2, with position 3 restricted to His/Tyr/Arg/Gln.","i":[[582,586,"EARAR"],[587,591,"EAHAR"],[592,596,"EAHAR"],[597,601,"EAYTR"],[602,606,"EAYGR"],[607,611,"EAYAR"],[612,616,"EAHTW"],[617,621,"EAHGR"],[622,626,"EARTR"],[627,631,"EAQAR"],[632,636,"EVRCR"],[637,641,"ETQVR"],[642,646,"ETQAR"]]}],"s":"METQKDEAAQAKGAAASGSTREQTAEKGAKNKAAEATEGPTSEPSSSGPGRLKKTAMKLFGGKKGICTLPSFFGGGRSKGSGKGSSKKGLSKSKTHDGLSEAAHGPEDVVSEGTGFSLPLPELPCQFPSSQSAHGALETGSRCKTSVAGATEKAVAEKFPSMPKPKKGLKGFFSSIRRHRKSKVTGAEQSEPGAKGPERVRARPHEHVSSAPQVPCFEETFQAPRKENANPQDAPGPKVSPTPEPSPPATEKMACKDPEKPMEACASAHVQPKPAPEASSLEEPHSPETGEKVVAGEVNPPNGPVGDPLSLLFGDVTSLKSFDSLTGCGDIIAEQDMDSMTDSMASGGQRANRDGTKRSSCLVTYQGGGEEMALPDDDDEEEEEEEEVELEEEEEEVKEEEEDDDLEYLWETAQMYPRPNMNLGYHPTTSPGHHGYMLLDPVRSYPGLAPGELLTPQSDQQESAPNSDEGYYDSTTPGFEDDSGEALGLVRRDCLPRDSYSGDALYEFYEPDDSLENSPPGDDCLYDLHGRSSEMFDPFLNFEPFLSSRPPGAMETEEERLVTIQKQLLYWELRREQLEAQEARAREAHAREAHAREAYTREAYGREAYAREAHTWEAHGREARTREAQAREVRCRETQVRETQARQEKPVLEYQMRPLGPSVMGLAAGVSGTSQISHRGITSAFPTTASSEPDWRDFRPLEKRYEGTCSKKDQSTCLMQLFQSDAMFEPDMQEANFGGSPRRAYPTYSPPEDPEEEEVEKEGNATVSFSQALVEFTSNGNLFSSMSCSSDSDSSFTQNLPELPPMVTFDIADVERDGEGKCEENPEFHNDEDLAASLEAFELGYYHKHAFNNYHSRFYQGLPWGVSSLPRYLGLPGLHPRPPPAAMALNRRSRSLDTAETLEMELSNSHLVQGYLESDELQAQQEDSDEEDEEEEEGEWSRDSPLSLYTEPPGAYDWPAWAPCPLPVGPGPAWISPNQLDRPSSQSPYRQATCCIPPMTMSISLSVPESRAPGESGPQLARPSHLHLPMGPCYNLQPQASQSMRARPRDVLLPVDEPSCSSSSGGFSPSPLPQAKPVGITHGIPQLPRVRPEHPQPQPTHYGPSSLDLSKERAEQGASLATSYSSTAMNGNLAK"},{"id":"SEQ_06770","a":"P11532","g":"DMD","d":"Dystrophin","L":3685,"m":[{"c":"xxxxφxxφxxxxψxx[WF]ψxxx-xxφx(x){25,77}φxxψxxψxoxΩxxφxxxφxxxxxxxxx","u":"77-129","sp":"tandem","x":"structured_like","cf":"high","why":"24-copy tandem array of ~108-aa alpha-helical bundle repeats (interrupted only by three short P/T-rich flexible hinges) anchored by two highly conserved aromatic/tryptophan motifs: an N-terminal [WF]ψxxx-xxφ helix and a C-terminal ψxxψxoxΩxxφxxxφ helix.","i":[[339,447,"VNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHR"],[448,556,"VLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQD"],[557,660,"ILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEK"],[719,828,"EIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEY"],[829,937,"QNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSDLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFD"],[938,1045,"TLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEE"],[1046,1154,"QMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG"],[1155,1264,"GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEV"],[1265,1367,"WACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQ"],[1368,1474,"SIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES"],[1475,1568,"KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEK"],[1569,1676,"CLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLE"],[1677,1780,"YQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL"],[1781,1895,"KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDD"],[1896,1972,"IEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFA"],[2000,2101,"YLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDR"],[2102,2208,"SVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEE"],[2209,2318,"QKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA"],[2319,2423,"QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVKETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK"],[2473,2577,"ADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNE"],[2578,2686,"MLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEE"],[2687,2802,"THRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEA"],[2803,2931,"SSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDE"],[2932,3040,"TLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHE"]]},{"c":"KxφxxWVxxoxxxΩ[GP]xxxψxNφx[ST]xφoDGxxLxxLψxxxx[GP]xxφx(x){48,49}xIxxxΩQV","u":"101-102","sp":"dispersed","x":"structured_like","cf":"medium","why":"N-terminal pair of ~101-102 aa globular repeat units separated by a 17-aa linker, sharing an ungapped 45-aa N-terminal core with invariant K, WV, N, DG, and LxxLψ anchors plus a conserved C-terminal xIxxxΩQV motif.","i":[[19,120,"KTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQV"],[138,238,"KILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQV"]]}],"s":"MLWWEEVEDCYEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSDLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVKETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM"},{"id":"SEQ_06772","a":"Q9ULJ7","g":"ANKRD50","d":"Ankyrin repeat domain-containing protein 50","L":1429,"m":[{"c":"GxT[AP]LxφAAxx(x){0,5}GHxxψφ(x){0,1}xLψxxGAxx[ND]xxDxx","u":"32-38","sp":"tandem","x":"structured_like","cf":"high","why":"Head-to-tail tandem array of 18 structured 33-aa repeats (residues 512-1109; one copy carries a 5-aa internal loop insertion and the C-terminal cap copy is 32 aa) strongly anchored by GxT[AP]L, central AAxxGH, hydrophobic core doublets (ψφ and Lψ), and C-terminal GAxx[ND]xxD.","i":[[512,544,"DRTSCIVRQALEREDSIRTLLDNGASVNQCDSN"],[545,577,"GRTLLANAAYSGSLDVVNLLVSRGADLEIEDAH"],[578,610,"GHTPLTLAARQGHTKVVNCLIGCGANINHTDQD"],[611,643,"GWTALRSAAWGGHTEVVSALLYAGVKVDCADAD"],[644,676,"SRTALRAAAWGGHEDIVLNLLQHGAEVNKADNE"],[677,709,"GRTALIAAAYMGHREIVEHLLDHGAEVNHEDVD"],[710,747,"GRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKD"],[748,780,"GMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNN"],[781,813,"GRTPLLAAASMGHASVVNTLLFWGAAVDSIDSE"],[814,846,"GRTVLSIASAQGNVEVVRTLLDRGLDENHRDDA"],[847,879,"GWTPLHMAAFEGHRLICEALIEQGARTNEIDND"],[880,912,"GRIPFILASQEGHYDCVQILLENKSNIDQRGYD"],[913,945,"GRNALRVAALEGHRDIVELLFSHGADVNCKDAD"],[946,978,"GRPTLYILALENQLTMAEYFLENGANVEASDAE"],[979,1011,"GRTALHVSCWQGHMEMVQVLIAYHADVNAADNE"],[1012,1044,"KRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQ"],[1045,1077,"GATALCIAAQEGHIDVVQVLLEHGADPNHADQF"],[1078,1109,"GRTAMRVAAKNGHSQIIKLLEKYGASSLNGCS"]]}],"s":"MTNPWEEKVCKMAQTSLLQGKQFYCREWVFHKLQHCLQEKSNCCNSAVNAPSLVMNSGNNASGVSGKGAAWGVLLVGGPGSGKTALCTELLWPSSPASLQRGLHRQALAFHFCKAQDSDTLCVGGFIRGLVAQICRSGLLQGYEDKLRDPAVQSLLQPGECERNPAEAFKRCVLLPLLGMKPPQQSLYLLVDSVDEGCNITEGEQTSTSLSGTVAALLAGHHEFFPPWLLLLCSARKQSKAVTKMFTGFRKISLDDLRKAYIVKDVQQYILHRLDQEEALRQHLTKETAEMLNQLHIKSSGCFLYLERVLDGVVENFIMLREIRDIPGTLNGLYLWLCQRLFVRKQFAKVQPILNVILAACRPLTITELYHAVWTKNMSLTLEDFQRKLDILSKLLVDGLGNTKILFHYSFAEWLLDVKHCTQKYLCNAAEGHRMLAMSYTCQAKNLTPLEAQEFALHLINSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGGDMQPSLRGLPNGPTHAFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTATAQTVPIDSFHNLSFTEQIQQHSLPRSRSRQSIVSPSSTTQSLGQSHNSPSSEFEWSQVKPSLKSTKASKGGKSENSAKSGSAGKKAKQSNSSQPKVLEYEMTQFDRRGPIAKSGTAAPPKQMPAESQCKIMIPSAQQEIGRSQQQFLIHQQSGEQKKRNGIMTNPNYHLQSNQVFLGRVSVPRTMQDRGHQEVLEGYPSSETELSLKQALKLQIEGSDPSFNYKKETPL"},{"id":"SEQ_06773","a":"Q9UMN6","g":"KMT2B","d":"Histone-lysine N-methyltransferase 2B","L":2715,"m":[{"c":"CxxC(x){9,12}C(x){2,3}CxxxφHxxC(x){5,21}C(x){2,9}C","u":"42-53","sp":"dispersed","x":"structured_like","cf":"high","why":"Four dispersed 42-53 aa cysteine/histidine-rich structured repeats sharing an invariant eight-ligand CxxC...C-x(2,3)-C-x3-φ-H-x2-C...C-x(2,9)-C architecture (with copies 1 and 2 separated by only 2 aa and copies 3 and 4 separated by longer linkers).","i":[[1204,1249,"CLLCASKGLHELVFCQVCCDPFHPFCLEEAERPLPQHHDTWCCRRC"],[1252,1300,"CHVCGRKGRGSKHLLECERCRHAYHPACLGPSYPTRATRKRRHWICSAC"],[1341,1393,"CTRCYEDNDYESKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPDSVLYTCGPC"],[1641,1682,"CELCLKPGATVGCCLSSCLSNFHFMCARASYCIFQDDKKVFC"]]},{"c":"[LS]PPPPLxPPx[PT]","u":11,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Three head-to-tail tandem 11-aa repeats in the N-terminal proline-rich disordered region anchored by a conserved leucine at position 6 ([LS]PPPPL) with exact 11-residue periodicity.","i":[[401,411,"LPPPPLTPPAP"],[412,422,"SPPPPLPPPST"],[423,433,"SPPPPLCPPPP"]]}],"s":"MAAAAGGGSCPGPGSARGRFPGRPRGAGGGGGRGGRGNGAERVRVALRRGGGATGPGGAEPGEDTALLRLLGLRRGLRRLRRLWAGPRVQRGRGRGRGRGWGPSRGCVPEEESSDGESDEEEFQGFHSDEDVAPSSLRSALRSQRGRAPRGRGRKHKTTPLPPPRLADVAPTPPKTPARKRGEEGTERMVQALTELLRRAQAPQAPRSRACEPSTPRRSRGRPPGRPAGPCRRKQQAVVVAEAAVTIPKPEPPPPVVPVKHQTGSWKCKEGPGPGPGTPRRGGQSSRGGRGGRGRGRGGGLPFVIKFVSRAKKVKMGQLSLGLESGQGQGQHEESWQDVPQRRVGSGQGGSPCWKKQEQKLDDEEEEKKEEEEKDKEGEEKEERAVAEEMMPAAEKEEAKLPPPPLTPPAPSPPPPLPPPSTSPPPPLCPPPPPPVSPPPLPSPPPPPAQEEQEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPTPSTATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEAPEPEPPPADDSPAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEVSPHGAPALSNGPQTQAQLLQPLQALQTQLLPQALPPPQPQLQPPPSPQQMPPLEKARIAGVGSLPLSGVEEKMFSLLKRAKVQLFKIDQQQQQKVAASMPLSPGGQMEEVAGAVKQISDRGPVRSEDESVEAKRERPSGPESPVQGPRIKHVCRHAAVALGQARAMVPEDVPRLSALPLRDRQDLATEDTSSASETESVPSRSRRGKVEAAGPGGESEPTGSGGTLAHTPRRSLPSHHGKKMRMARCGHCRGCLRVQDCGSCVNCLDKPKFGGPNTKKQCCVYRKCDKIEARKMERLAKKGRTIVKTLLPWDSDESPEASPGPPGPRRGAGAGGPREEVVAHPGPEEQDSLLQRKSARRCVKQRPSYDIFEDSDDSEPGGPPAPRRRTPRENELPLPEPEEQSRPRKPTLQPVLQLKARRRLDKDALAPGPFASFPNGWTGKQKSPDGVHRVRVDFKEDCDLENVWLMGGLSVLTSVPGGPPMVCLLCASKGLHELVFCQVCCDPFHPFCLEEAERPLPQHHDTWCCRRCKFCHVCGRKGRGSKHLLECERCRHAYHPACLGPSYPTRATRKRRHWICSACVRCKSCGATPGKNWDVEWSGDYSLCPRCTQLYEKGNYCPICTRCYEDNDYESKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPDSVLYTCGPCAGAAQPRWREALSGALQGGLRQVLQGLLSSKVVGPLLLCTQCGPDGKQLHPGPCGLQAVSQRFEDGHYKSVHSFMEDMVGILMRHSEEGETPDRRAGGQMKGLLLKLLESAFGWFDAHDPKYWRRSTRLPNGVLPNAVLPPSLDHVYAQWRQQEPETPESGQPPGDPSAAFQGKDPAAFSHLEDPRQCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFEENDGSLKNVHAAVARGRQMRCELCLKPGATVGCCLSSCLSNFHFMCARASYCIFQDDKKVFCQKHTDLLDGKEIVNPDGFDVLRRVYVDFEGINFKRKFLTGLEPDAINVLIGSIRIDSLGTLSDLSDCEGRLFPIGYQCSRLYWSTVDARRRCWYRCRILEYRPWGPREEPAHLEAAEENQTIVHSPAPSSEPPGGEDPPLDTDVLVPGAPERHSPIQNLDPPLRPDSGSAPPPAPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDPDFPAPPRRSRRPSPLAPRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAPSPPPPEDLGPDFEDMEVVSGLSAADLDFAASLLGTEPFQEEIVAAGAMGSSHGGPGDSSEEESSPTSRYIHFPVTVVSAPGLAPSATPGAPRIEQLDGVDDGTDSEAEAVQQPRGQGTPPSGPGVVRAGVLGAAGDRARPPEDLPSEIVDFVLKNLGGPGDGGAGPREESLPPAPPLANGSQPSQGLTASPADPTRTFAWLPGAPGVRVLSLGPAPEPPKPATSKIILVNKLGQVFVKMAGEGEPVPPPVKQPPLPPTISPTAPTSWTLPPGPLLGVLPVVGVVRPAPPPPPPPLTLVLSSGPASPPRQAIRVKRVSTFSGRSPPAPPPYKAPRLDEDGEASEDTPQVPGLGSGGFSRVRMKTPTVRGVLDLDRPGEPAGEESPGPLQERSPLLPLPEDGPPQVPDGPPDLLLESQWHHYSGEASSSEEEPPSPDDKENQAPKRTGPHLRFEISSEDGFSVEAESLEGAWRTLIEKVQEARGHARLRHLSFSGMSGARLLGIHHDAVIFLAEQLPGAQRCQHYKFRYHQQGEGQEEPPLNPHGAARAEVYLRKCTFDMFNFLASQHRVLPEGATCDEEEDEVQLRSTRRATSLELPMAMRFRHLKKTSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIEDASNKLPCNCGAKRCRRFLN"},{"id":"SEQ_06774","a":"Q8TC56","g":"GARIN3","d":"Golgi-associated RAB2 interactor protein 3","L":605,"m":[{"c":"[AS]ψ[AV]GAAxxxxx[GSE]xx[STL]","u":15,"sp":"tandem","x":"mixed","cf":"high","why":"Five 15-aa repeats anchored by an invariant [AS]ψ[AV]GAA N-terminal core (with large aliphatic I/L/M at position 2 and fixed GAA at positions 4-6) followed by a polar/Ser-Thr-rich half. Copies 2-5 form a contiguous tandem array (2, 0, and 0 aa gaps) with copy 1 located one 14-aa diverged repeat unit upstream.","i":[[283,297,"AIAGAAMSPATGAMS"],[312,326,"ALAGAAIKNPGENES"],[329,343,"SMAGAANISSEGISL"],[344,358,"ALVGAASTSLEGTST"],[359,373,"SMAGAASLSQDSSLS"]]}],"s":"MSNESCLPYYTAHSYSSMSAFKTSMGDLQRQLYNRGEYNIFKYAPMFESNFIQINKKGEVIDVHNRVRMVTVGIVCTSPILPLPDVMVLAQPTKICEQHVRWGRFAKGRGRRPVKTLELTRLLPLKFVKISIHDHEKQQLRLKLATGRTFYLQLCPSSDTREDLFCYWEKLVYLLRPPVESYCSTPTLLSGDAPPEDNKSLVAAELHREGDQSETGLYKPCDVSAATSSAYAGGEGIQHASHGTASAASPSTSTPGAAEGGAARTAGGMAVAGTATGPRTDVAIAGAAMSPATGAMSIATTKSAGPGQVTTALAGAAIKNPGENESSKSMAGAANISSEGISLALVGAASTSLEGTSTSMAGAASLSQDSSLSAAFAGSITTSKCAAERTEGPAVGPLISTLQSEGYMSERDGSQKVSQPSAEVWNENKERREKKDRHPSRKSSHHRKAGESHRRRAGDKNQKASSHRSASGHKNTRDDKKEKGYSNVRGKRHGSSRKSSTHSSTKKESRTTQELGKNQSASSTGALQKKASKISSFLRSLRATPGSKTRVTSHDREVDIVAKMVEKQNIEAKVEKAQGGQELEMISGTMTSEKTEMIVFETKSI"},{"id":"SEQ_06778","a":"Q8WYL5","g":"SSH1","d":"Protein phosphatase Slingshot homolog 1","L":1049,"m":[{"c":"-SIxoψ(x){1,2}K[AP]GLV+[KQ][HR]T[KQ]EψE","u":"20-21","sp":"dispersed","x":"disordered_like","cf":"high","why":"Two-copy internal motif duplication in the long C-terminal disordered region (residues 811-830 and 939-959) sharing 9 exact residue identities (S, I, K, G, L, V, T, E, E) and 9 physicochemically or tightly constrained positions across a 20-21 aa span with a 1-2 residue internal linker.","i":[[811,830,"ESIIQLQKAGLVRKHTKELE"],[939,959,"DSIHSVRGKPGLVKQRTQEIE"]]}],"s":"MALVTLQRSPTPSAASSSASNSELEAGSEEDRKLNLSLSESFFMVKGAALFLQQGSSPQGQRSLQHPHKHAGDLPQHLQVMINLLRCEDRIKLAVRLESAWADRVRYMVVVYSSGRQDTEENILLGVDFSSKESKSCTIGMVLRLWSDTKIHLDGDGGFSVSTAGRMHIFKPVSVQAMWSALQVLHKACEVARRHNYFPGGVALIWATYYESCISSEQSCINEWNAMQDLESTRPDSPALFVDKPTEGERTERLIKAKLRSIMMSQDLENVTSKEIRNELEKQMNCNLKELKEFIDNEMLLILGQMDKPSLIFDHLYLGSEWNASNLEELQGSGVDYILNVTREIDNFFPGLFAYHNIRVYDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAYAMKEFGWPLEKAYNYVKQKRSITRPNAGFMRQLSEYEGILDASKQRHNKLWRQQTDSSLQQPVDDPAGPGDFLPETPDGTPESQLPFLDDAAQPGLGPPLPCCFRRLSDPLLPSPEDETGSLVHLEDPEREALLEEAAPPAEVHRPARQPQQGSGLCEKDVKKKLEFGSPKGRSGSLLQVEETEREEGLGAGRWGQLPTQLDQNLLNSENLNNNSKRSCPNGMEDDAIFGILNKVKPSYKSCADCMYPTASGAPEASRERCEDPNAPAICTQPAFLPHITSSPVAHLASRSRVPEKPASGPTEPPPFLPPAGSRRADTSGPGAGAALEPPASLLEPSRETPKVLPKSLLLKNSHCDKNPPSTEVVIKEESSPKKDMKPAKDLRLLFSNESEKPTTNSYLMQHQESIIQLQKAGLVRKHTKELERLKSVPADPAPPSRDGPASRLEASIPEESQDPAALHELGPLVMPSQAGSDEKSEAAPASLEGGSLKSPPPFFYRLDHTSSFSKDFLKTICYTPTSSSMSSNLTRSSSSDSIHSVRGKPGLVKQRTQEIETRLRLAGLTVSSPLKRSHSLAKLGSLTFSTEDLSSEADPSTVADSQDTTLSESSFLHEPQGTPRDPAATSKPSGKPAPENLKSPSWMSKS"},{"id":"SEQ_06782","a":"Q9ULH1","g":"ASAP1","d":"Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1","L":1129,"m":[{"c":"-L[PA][PQ]KPx","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Eight-copy tandem proline-rich array in the C-terminal disordered region (residues 929-994, separated by 0 or 2 aa linkers) anchored by strictly conserved L, K, and P positions and an N-terminal acidic (D/E) residue.","i":[[929,935,"ELPQKPP"],[938,944,"DLPPKPT"],[945,951,"ELAPKPQ"],[954,960,"DLPPKPG"],[961,967,"ELPPKPQ"],[970,976,"DLPPKPQ"],[979,985,"DLPPKPQ"],[988,994,"DLPPKPQ"]]},{"c":"G[EN]T[AV]L[HD]φ[AC]x[RM](x){8,11}[FL]Lx[QR]x[CK]xxxxxxxxx","u":"33-36","sp":"tandem","x":"structured_like","cf":"high","why":"Three head-to-tail 33-36 aa structured repeats (residues 601-702) defined by a conserved G[EN]T[AV]L N-terminal helix-turn signature and a second hydrophobic [FL]L-containing helix separated by an 8-11 aa loop.","i":[[601,636,"GETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTAL"],[637,669,"GNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQA"],[670,702,"GETALDIAKRLKATQCEDLLSQAKSGKFNPHVH"]]}],"s":"MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD"},{"id":"SEQ_06788","a":"Q8IZQ1","g":"WDFY3","d":"WD repeat and FYVE domain-containing protein 3","L":3526,"m":[{"c":"[LF]xxxx(x){0,5}x[IV]x[CA][ALC]xxxxxx(x){0,5}xx[IL][VT][GST][GCD]x(x){0,1}x[GTR]x[VIC]xxW","u":"30-37","sp":"dispersed","x":"structured_like","cf":"high","why":"Five C-terminal structured repeats of 30-37 aa anchored by an N-terminal [LF], an internal hydrophobic core ([IV]x[CA][ALC] and [IL][VT][GST][GCD]), and an invariant C-terminal W. The first four copies are closely arrayed with 10-18 aa linkers, whereas the fifth copy is separated by a 154 aa disordered insertion.","i":[[3076,3105,"LSEWGQILCAICPNPKLVITGGTSTVVCVW"],[3123,3154,"LLGHTDTVTCATASLAYHIIVSGSRDRTCIIW"],[3165,3195,"LRGHRAPVSALCINELTGDIVSCAGTYIHVW"],[3208,3244,"FTGRSQQIICCCMSEMNEWDTQNVIVTGHSDGVVRFW"],[3402,3437,"FDRKDNAHPAEVTALGISKDHSRILVGDSRGRVFSW"]]}],"s":"MNMVKRIMGRPRQEECSPQDNALGLMHLRRLFTELCHPPRHMTQKEQEEKLYMMLPVFNRVFGNAPPNTMTEKFSDLLQFTTQVSRLMVTEIRRRASNKSTEAASRAIVQFLEINQSEEASRGWMLLTTINLLASSGQKTVDCMTTMSVPSTLVKCLYLFFDLPHVPEAVGGAQNELPLAERRGLLQKVFVQILVKLCSFVSPAEELAQKDDLQLLFSAITSWCPPYNLPWRKSAGEVLMTISRHGLSVNVVKYIHEKECLSTCVQNMQQSDDLSPLEIVEMFAGLSCFLKDSSDVSQTLLDDFRIWQGYNFLCDLLLRLEQAKEAESKDALKDLVNLITSLTTYGVSELKPAGITTGAPFLLPGFAVPQPAGKGHSVRNVQAFAVLQNAFLKAKTSFLAQIILDAITNIYMADNANYFILESQHTLSQFAEKISKLPEVQNKYFEMLEFVVFSLNYIPCKELISVSILLKSSSSYHCSIIAMKTLLKFTRHDYIFKDVFREVGLLEVMVNLLHKYAALLKDPTQALNEQGDSRNNSSVEDQKHLALLVMETLTVLLQGSNTNAGIFREFGGARCAHNIVKYPQCRQHALMTIQQLVLSPNGDDDMGTLLGLMHSAPPTELQLKTDILRALLSVLRESHRSRTVFRKVGGFVYITSLLVAMERSLSCPPKNGWEKVNQNQVFELLHTVFCTLTAAMRYEPANSHFFKTEIQYEKLADAVRFLGCFSDLRKISAMNVFPSNTQPFQRLLEEDVISIESVSPTLRHCSKLFIYLYKVATDSFDSRAEQIPPCLTSESSLPSPWGTPALSRKRHAYHSVSTPPVYPPKNVADLKLHVTTSSLQSSDAVIIHPGAMLAMLDLLASVGSVTQPEHALDLQLAVANILQSLVHTERNQQVMCEAGLHARLLQRCSAALADEDHSLHPPLQRMFERLASQALEPMVLREFLRLASPLNCGAWDKKLLKQYRVHKPSSLSYEPEMRSSMITSLEGLGTDNVFSLHEDNHYRISKSLVKSAEGSTVPLTRVKCLVSMTTPHDIRLHGSSVTPAFVEFDTSLEGFGCLFLPSLAPHNAPTNNTVTTGLIDGAVVSGIGSGERFFPPPSGLSYSSWFCIEHFSSPPNNHPVRLLTVVRRANSSEQHYVCLAIVLSAKDRSLIVSTKEELLQNYVDDFSEESSFYEILPCCARFRCGELIIEGQWHHLVLVMSKGMLKNSTAALYIDGQLVNTVKLHYVHSTPGGSGSANPPVVSTVYAYIGTPPAQRQIASLVWRLGPTHFLEEVLPSSNVTTIYELGPNYVGSFQAVCMPCKDAKSEGVVPSPVSLVPEEKVSFGLYALSVSSLTVARIRKVYNKLDSKAIAKQLGISSHENATPVKLIHNSAGHLNGSARTIGAALIGYLGVRTFVPKPVATTLQYVGGAAAILGLVAMASDVEGLYAAVKALVCVVKSNPLASKEMERIKGYQLLAMLLKKKRSLLNSHILHLTFSLVGTVDSGHETSIIPNSTAFQDLLCDFEVWLHAPYELHLSLFEHFIELLTESSEASKNAKLMREFQLIPKLLLTLRDMSLSQPTIAAISNVLSFLLQGFPSSNDLLRFGQFISSTLPTFAVCEKFVVMEINNEEKLDTGTEEEFGGLVSANLILLRNRLLDILLKLIYTSKEKTSINLQACEELVKTLGFDWIMMFMEEHLHSTTVTAAMRILVVLLSNQSILIKFKEGLSGGGWLEQTDSVLTNKIGTVLGFNVGRSAGGRSTVREINRDACHFPGFPVLQSFLPKHTNVPALYFLLMALFLQQPVSELPENLQVSVPVISCRSKQGCQFDLDSIWTFIFGVPASSGTVVSSIHNVCTEAVFLLLGMLRSMLTSPWQSEEEGSWLREYPVTLMQFFRYLYHNVPDLASMWMSPDFLCALAATVFPFNIRPYSEMVTDLDDEVGSPAEEFKAFAADTGMNRSQSEYCNVGTKTYLTNHPAKKFVFDFMRVLIIDNLCLTPASKQTPLIDLLLEASPERSTRTQQKEFQTYILDSVMDHLLAADVLLGEDASLPITSGGSYQVLVNNVFYFTQRVVDKLWQGMFNKESKLLIDFIIQLIAQSKRRSQGLSLDAVYHCLNRTILYQFSRAHKTVPQQVALLDSLRVLTVNRNLILGPGNHDQEFISCLAHCLINLHVGSNVDGFGLEAEARMTTWHIMIPSDIEPDGSYSQDISEGRQLLIKAVNRVWTELIHSKKQVLEELFKVTLPVNERGHVDIATARPLIEEAALKCWQNHLAHEKKCISRGEALAPTTQSKLSRVSSGFGLSKLTGSRRNRKESGLNKHSLSTQEISQWMFTHIAVVRDLVDTQYKEYQERQQNALKYVTEEWCQIECELLRERGLWGPPIGSHLDKWMLEMTEGPCRMRKKMVRNDMFYNHYPYVPETEQETNVASEIPSKQPETPDDIPQKKPARYRRAVSYDSKEYYMRLASGNPAIVQDAIVESSEGEAAQQEPEHGEDTIAKVKGLVKPPLKRSRSAPDGGDEENQEQLQDQIAEGSSIEEEEKTDNATLLRLLEEGEKIQHMYRCARVQGLDTSEGLLLFGKEHFYVIDGFTMTATREIRDIETLPPNMHEPIIPRGARQGPSQLKRTCSIFAYEDIKEVHKRRYLLQPIAVEVFSGDGRNYLLAFQKGIRNKVYQRFLAVVPSLTDSSESVSGQRPNTSVEQGSGLLSTLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGETPAYHYGTHYSSAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNMADVKELIPEFFYLPEFLFNSNNFDLGCKQNGTKLGDVILPPWAKGDPREFIRVHREALECDYVSAHLHEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQLFKKPHPPKRVRSRLNGDNAGISVLPGSTSDKIFFHHLDNLRPSLTPVKELKEPVGQIVCTDKGILAVEQNKVLIPPTWNKTFAWGYADLSCRLGTYESDKAMTVYECLSEWGQILCAICPNPKLVITGGTSTVVCVWEMGTSKEKAKTVTLKQALLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLSFLTQLRGHRAPVSALCINELTGDIVSCAGTYIHVWSINGNPIVSVNTFTGRSQQIICCCMSEMNEWDTQNVIVTGHSDGVVRFWRMEFLQVPETPAPEPAEVLEMQEDCPEAQIGQEAQDEDSSDSEADEQSISQDPKDTPSQPSSTSHRPRAASCRATAAWCTDSGSDDSRRWSDQLSLDEKDGFIFVNYSEGQTRAHLQGPLSHPHPNPIEVRNYSRLKPGYRWERQLVFRSKLTMHTAFDRKDNAHPAEVTALGISKDHSRILVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQNCYYNLQHERGSEDGPRNC"},{"id":"SEQ_06803","a":"Q9NRF2","g":"SH2B1","d":"SH2B adapter protein 1","L":756,"m":[{"c":"[PV][PV][EV]EL[EV]","u":6,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Three tandem 6-aa repeats in the C-terminal G/A/P/E-rich disordered tail with invariant EL anchors at positions 4-5 and constrained P/V/E positions (including an exact tandem VPVVEL duplication preceded by degenerate VPEEL).","i":[[688,693,"VPEELV"],[694,699,"PVVELV"],[700,705,"PVVELE"]]}],"s":"MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEEGPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQEPTTSHDPPQPPEPPSWTDPPQPGAEEASRAPEVAAAAAAAAKERQEKEKAGGGGVPEELVPVVELVPVVELEEAIAPGSEAQGAGSGGDAGVPPMVQLQQSPLGGDGEEGGHPRAINNQYSFV"},{"id":"SEQ_06805","a":"P11137","g":"MAP2","d":"Microtubule-associated protein 2","L":1827,"m":[{"c":"GS[TL][DK]N[IA][KRH][YH]xP[KG]GGxV[QK]Ix[ST]xK[IL][DN][LF](x){4,5}[SA]+[CV]","u":"31-32","sp":"tandem","x":"mixed","cf":"high","why":"Three head-to-tail tandem 31-32 aa C-terminal repeats anchored by invariant GS, N, P[KG]GG, V[QK]I, and K[IL][DN][LF] motifs followed by a 4-5 residue linker and a conserved [SA]+[CV] C-terminal cap.","i":[[1678,1708,"GSTDNIKYQPKGGQVQIVTKKIDLSHVTSKC"],[1709,1740,"GSLKNIRHRPGGGRVKIESVKLDFKEKAQAKV"],[1741,1772,"GSLDNAHHVPGGGNVKIDSQKLNFREHAKARV"]]},{"c":"TP[GTH]TP[GP][ST]x","u":8,"sp":"periodic","x":"disordered_like","cf":"high","why":"Four closely spaced 8-aa repeats separated by regular 2-4 aa linkers within a C-terminal proline/threonine-rich disordered region, defined by a conserved TP[GTH]TP[GP][ST] core.","i":[[1592,1599,"TPTTPGST"],[1602,1609,"TPGTPPSY"],[1613,1620,"TPGTPGTP"],[1625,1632,"TPHTPGTP"]]}],"s":"MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGEHGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKSSIQELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEATKSIEPGSDYYELSDTRESVHESIDTMSPMHKNGDKEFQTGKESQPSPPAQEAGYSTLAQSYPSDLPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPVESKEEEQIEKVKATGEESTQAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSETVVEDSRTGLPPVTDENHVIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFSVDKEASAHISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDLSIPTDASSEKAEKGLSSVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATDERADVQMEFIQGPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQITDLGVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQPKGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL"},{"id":"SEQ_06810","a":"Q9HCI5","g":"MAGEE1","d":"Melanoma-associated antigen E1","L":957,"m":[{"c":"xPTxx-G[PL]STSV","u":12,"sp":"tandem","x":"disordered_like","cf":"high","why":"Contiguous head-to-tail array of 30 tandem 12-residue units across the N-terminal Pro/Thr/Ser-rich disordered region (residues 57-416), anchored by conserved PT, acidic-glycine (-G), [PL], and STSV positions.","i":[[57,68,"GLCASEGPSTSV"],[69,80,"LPTSAEGPSTFV"],[81,92,"PPTISEASSASG"],[93,104,"QPTISEGPGTSV"],[105,116,"LPTPSEGLSTSG"],[117,128,"PPTISKGLCTSV"],[129,140,"TLAASEGRNTSR"],[141,152,"PPTSSEEPSTSV"],[153,164,"PPTASEVPSTSL"],[165,176,"PPTPGEGTSTSV"],[177,188,"PPTAYEGPSTSV"],[189,200,"VPTPDEGPSTSV"],[201,212,"LPTPGEGPGTSV"],[213,224,"PLAATEGLSTSV"],[225,236,"QATPDEGPSTSV"],[237,248,"PPTATEGLSTPV"],[249,260,"PPTRDEGPSTSV"],[261,272,"PATPGEGPSTSV"],[273,284,"LPAASDGQSISL"],[285,296,"VPTRGKGSSTSV"],[297,308,"PPTATEGLSTSV"],[309,320,"QPTAGEGSSTSV"],[321,332,"PPTPGGGLSTSV"],[333,344,"PPTATEELSTSV"],[345,356,"PPTPGEGPSTSV"],[357,368,"LPIPGEGLSTSV"],[369,380,"PPTASDGSDTSV"],[381,392,"PPTPGEGASTLV"],[393,404,"QPTAPDGPGSSV"],[405,416,"LPNPGEGPSTLF"]]},{"c":"xLψQφφLψxDo[ST]KφPIxxxxψxxYIx+ExxxxFP-ψLxRAAxxLxxψΩxxELxxLDPxxH[ST]YxLφN+xxxxxxExψx-SPNxPxxxφLMxψLxxIFψxGNxA+E[AS]xψWxφLxxψGVQxxR+xxIxxxx(x){2,10}QRYψDxxxVxDxxPVxYEFφWGPR[AS][HR]LET[ST]KMKφL+ΩψA+IxxK-PxDWPxxYxEAψE--AxRA","u":"194-202","sp":"dispersed","x":"structured_like","cf":"high","why":"Large C-terminal internal domain duplication (~200 aa, separated by a 52-aa linker) showing ~33% sequence identity and collinear conservation of hydrophobic cores and signature motifs (FP-ψLxRAA, LDPxxH[ST]Y, IFψxGNxA+E, QRYψD, PVxYEFφWGPRxxLETxKMK, and DWPxxYxEAψE--AxRA) across a single 8-aa loop length difference.","i":[[497,698,"ELLQFLLVKDQSKYPIRESEMREYIVKEYRNQFPEILRRAAAHLECIFRFELRELDPEAHTYILLNKLGPVPFEGLEESPNGPKMGLLMMILGQIFLNGNQAKEAEIWEMLWRMGVQRERRLSIFGNPKRLLSVEFVWQRYLDYRPVTDCKPVEYEFFWGPRSHLETTKMKILKFMAKIYNKDPMDWPEKYNEALEEDAARA"],[751,944,"KLVQLFLLMDSTKLPIPKKGILYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYTLYNRREMEETEEIVDSPNRPGNNFLMQVLSFIFIMGNHARESAVWAFLRGLGVQAGRKHVITCRYLSQRYIDSLRVPDSDPVQYEFVWGPRARLETSKMKALRYVARIHRKEPQDWPQQYREAMEDEANRA"]]}],"s":"MSLVSQNSRRRRRRVAKATAHNSSWGEMQAPNAPGLPADVPGSDVPQGPSDSQILQGLCASEGPSTSVLPTSAEGPSTFVPPTISEASSASGQPTISEGPGTSVLPTPSEGLSTSGPPTISKGLCTSVTLAASEGRNTSRPPTSSEEPSTSVPPTASEVPSTSLPPTPGEGTSTSVPPTAYEGPSTSVVPTPDEGPSTSVLPTPGEGPGTSVPLAATEGLSTSVQATPDEGPSTSVPPTATEGLSTPVPPTRDEGPSTSVPATPGEGPSTSVLPAASDGQSISLVPTRGKGSSTSVPPTATEGLSTSVQPTAGEGSSTSVPPTPGGGLSTSVPPTATEELSTSVPPTPGEGPSTSVLPIPGEGLSTSVPPTASDGSDTSVPPTPGEGASTLVQPTAPDGPGSSVLPNPGEGPSTLFSSSASVDRNPSKCSLVLPSPRVTKASVDSDSEGPKGAEGPIEFEVLRDCESPNSISIMGLNTSRVAITLKPQDPMEQNVAELLQFLLVKDQSKYPIRESEMREYIVKEYRNQFPEILRRAAAHLECIFRFELRELDPEAHTYILLNKLGPVPFEGLEESPNGPKMGLLMMILGQIFLNGNQAKEAEIWEMLWRMGVQRERRLSIFGNPKRLLSVEFVWQRYLDYRPVTDCKPVEYEFFWGPRSHLETTKMKILKFMAKIYNKDPMDWPEKYNEALEEDAARAFAEGWQALPHFRRPFFEEAAAEVPSPDSEVSSYSSKYAPHSWPESRLESKARKLVQLFLLMDSTKLPIPKKGILYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYTLYNRREMEETEEIVDSPNRPGNNFLMQVLSFIFIMGNHARESAVWAFLRGLGVQAGRKHVITCRYLSQRYIDSLRVPDSDPVQYEFVWGPRARLETSKMKALRYVARIHRKEPQDWPQQYREAMEDEANRADVGHRQIFVHNFR"},{"id":"SEQ_06812","a":"Q96NW7","g":"LRRC7","d":"Leucine-rich repeat-containing protein 7","L":1575,"m":[{"c":"ψxxφxφxxNxφxxφPxxφxx[LC](x){2,3}","u":"23-24","sp":"tandem","x":"structured_like","cf":"high","why":"Head-to-tail tandem array of 17 structured repeats (residues 62-453; 24 aa in copy 1 and 23 aa in copies 2-17) anchored by strictly phased hydrophobic positions (ψxxφxφxxNxφxxφ), a conserved Asn at position 9, and a Pro-x-x-φ-x-x-[LC] C-terminal segment.","i":[[62,85,"ISVLDYSHCSLQQVPKEVFNFERT"],[86,108,"LEELYLDANQIEELPKQLFNCQA"],[109,131,"LRKLSIPDNDLSNLPTTIASLVN"],[132,154,"LKELDISKNGVQEFPENIKCCKC"],[155,177,"LTIIEASVNPISKLPDGFTQLLN"],[178,200,"LTQLYLNDAFLEFLPANFGRLVK"],[201,223,"LRILELRENHLKTLPKSMHKLAQ"],[224,246,"LERLDLGNNEFGELPEVLDQIQN"],[247,269,"LRELWMDNNALQVLPGSIGKLKM"],[270,292,"LVYLDMSKNRIETVDMDISGCEA"],[293,315,"LEDLLLSSNMLQQLPDSIGLLKK"],[316,338,"LTTLKVDDNQLTMLPNTIGNLSL"],[339,361,"LEEFDCSCNELESLPSTIGYLHS"],[362,384,"LRTLAVDENFLPELPREIGSCKN"],[385,407,"VTVMSLRSNKLEFLPEEIGQMQK"],[408,430,"LRVLNLSDNRLKNLPFSFTKLKE"],[431,453,"LAALWLSDNQSKALIPLQTEAHP"]]}],"s":"MMENLIRGRNPPQYQRSPCKEVRAALRKRPEEELQCLEMTTKRKIIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQPRGDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDENAGKVKDLSCQAPWERGQRGITLQPARLSGDCCTPWARCDQQIQDMPVPQNDPQLAWGCISGLQQERSMCTPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGVRVENSNPTANTEQTVKEKYEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPPKLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSGSSNTRVKVGSLQTTAKDAVHNSLWGNRIAPSFPQPLDSKPLLSQREAVPPGNIPQRPDRLPMSDTFTDNWTDGSHYDNTGFVAEETTAENANSNPLLSSKSRSTSSHGRRPLIRQDRIVGVPLELEQSTHRHTPETEVPPSNPWQNWTRTPSPFEDRTAFPSKLETTPTTSPLPERKEHIKESTEIPSPFSPGVPWEYHDSNPNRSLSNVFSQIHCRPESSKGVISISKSTERLSPLMKDIKSNKFKKSQSIDEIDIGTYKVYNIPLENYASGSDHLGSHERPDKMLGPEHGMSSMSRSQSVPMLDDEMLTYGSSKGPQQQKASMTKKVYQFDQSFNPQGSVEVKAEKRIPPPFQHNPEYVQQASKNIAKDLISPRAYRGYPPMEQMFSFSQPSVNEDAVVNAQFASQGARAGFLRRADSLVSATEMAMFRRVNEPHELPPTDRYGRPPYRGGLDRQSSVTVTESQFLKRNGRYEDEHPSYQEVKAQAGSFPVKNLTQRRPLSARSYSTESYGASQTRPVSARPTMAALLEKIPSDYNLGNYGDKPSDNSDLKTRPTPVKGEESCGKMPADWRQQLLRHIEARRLDRNAAYKHNTVNLGMLPYGGISAMHAGRSMTLNLQTKSKFDHQELPLQKTPSQQSNILDNGQEDVSPSGQWNPYPLGRRDVPPDTITKKAGSHIQTLMGSQSLQHRSREQQPYEGNINKVTIQQFQSPLPIQIPSSQATRGPQPGRCLIQTKGQRSMDGYPEQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKILQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQRELTV"},{"id":"SEQ_06873","a":"A6NEQ0","g":"RBMY1E","d":"RNA-binding motif protein, Y chromosome, family 1 member E","L":496,"m":[{"c":"[QR]ETR-YAPP[SH]R[GD][HY][AG]YRD[NY]GHS[NRS][RW][DH]E[HS][SY]SRGY[RS][NY][HR]x[SG][SY]","u":37,"sp":"tandem","x":"disordered_like","cf":"high","why":"Four contiguous head-to-tail 37-aa repeats in the R/Y/S/H/G-rich disordered central region with extreme multi-position conservation including fixed ETR-YAPPxR, YRDxGHS, and ExxSRGY anchors.","i":[[226,262,"QETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSS"],[263,299,"RETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNRRSS"],[300,336,"RETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSS"],[337,373,"RETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGY"]]}],"s":"MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRTSKSRGFAFITFENPADAKNAAKDMNGKSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSRGGTRGWLPSQEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSYRDALQRYGTAHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVCRKDQRNPPSLGRVLPDPREACGSSSYVASIVDGGESRSEKGDSSRY"},{"id":"SEQ_06875","a":"Q8WYR4","g":"RSPH1","d":"Radial spoke head 1 homolog","L":309,"m":[{"c":"x[NDT][GN][DAS][TRK]YxG[EST]Ωxxxxx[RKQ][HE]G[QHT][GA]xφx[FYH]","u":23,"sp":"tandem","x":"structured_like","cf":"high","why":"Five tandem 23-aa beta-hairpin-like structured repeats (0-1 aa gap) pairing a conserved N-terminal GxxYxG[EST]Ω motif with a C-terminal +HG[QH]GxΩxΩ motif (partially diverged in the fifth copy and flanked by more divergent N/C-terminal capping repeats).","i":[[39,61,"PNGDTYEGSYEFGKRHGQGIYKF"],[62,84,"KNGARYIGEYVRNKKHGQGTFIY"],[85,107,"PDGSRYEGEWANDLRHGHGVYYY"],[108,130,"INNDTYTGEWFAHQRHGQGTYLY"],[132,154,"ETGSKYVGTWVNGQQEGTAELIH"]]}],"s":"MSDLGSEELEEEGENDIGEYEGGRNEAGERHGRGRARLPNGDTYEGSYEFGKRHGQGIYKFKNGARYIGEYVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTYLYAETGSKYVGTWVNGQQEGTAELIHLNHRYQGKFLNKNPVGPGKYVFDVGCEQHGEYRLTDMERGEEEEEEELVTVVPKWKATQITELALWTPTLPKKPTSTDGPGQDAPGAESAGEPGEEAQALLEGFEGEMDMRPGDEDADVLREESREYDQEEFRYDMDEGNINSEEEETRQSDLQD"},{"id":"SEQ_06878","a":"P46821","g":"MAP1B","d":"Microtubule-associated protein 1B","L":2468,"m":[{"c":"YxY-xx[EGT]+[TI]T[RKS]x[PS]xx[SGE][GTD]","u":17,"sp":"tandem","x":"disordered_like","cf":"high","why":"Eight well-conserved 17-aa repeats in the C-terminal disordered region anchored by an invariant YxY[ED] N-terminal motif, a central [KR][TI]T[RKS]x[PS] core, and a [SGE][GTD] C-terminal turn. Five head-to-tail tandem copies and three head-to-tail tandem copies are separated in-register by a 34-aa (two-unit) degenerate segment, with divergent boundary remnants immediately flanking the array.","i":[[1887,1903,"YDYESYEKTTRTSDVGG"],[1904,1920,"YYYEKIERTTKSPSDSG"],[1921,1937,"YSYETIGKTTKTPEDGD"],[1938,1954,"YSYEIIEKTTRTPEEGG"],[1955,1971,"YSYDISEKTTSPPEVSG"],[2006,2022,"YSYETTEKITSFPESEG"],[2023,2039,"YSYETSTKTTRTPDTST"],[2040,2056,"YCYETAEKITRTPQAST"]]}],"s":"MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRAIGNIELGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVPGQKILHHRSDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFIEIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEMEGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNMLINGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNSDWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVGNTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQWTGTNKDKAEFILPNGQEVDLPISYLTSVSSLIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLSPKSDISPLTPRESSPLYSPTFSDSTSAVKEKTATCHSSSSPPIDAASAEPYGFRASVLFDTMQHHLALNRDLSTPGLEKDSGGKTPGDFSYAYQKPEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGKTTKTPEDGDYSYEIIEKTTRTPEEGGYSYDISEKTTSPPEVSGYSYEKTERSRRLLDDISNGYDDSEDGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTSTYCYETAEKITRTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGNDPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLASSSTVVMQDESFPACKIEL"},{"id":"SEQ_06926","a":"I3L273","g":"GFY","d":"Golgi-associated olfactory signaling regulator","L":518,"m":[{"c":"[HNR]P[EGD][SFP][PS][EGK]TP","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Six dispersed octapeptide repeats in the Pro/Ser/Thr-rich disordered N-terminal region anchored by invariant P2, T7, and P8 positions, predominantly HP at positions 1-2 (4/6 copies), and tightly constrained acidic/polar/proline internal positions.","i":[[58,65,"NPEFPGTP"],[98,105,"HPESPETP"],[130,137,"HPESSETP"],[146,153,"HPGSPETP"],[162,169,"RPEFPETP"],[234,241,"HPDPSKTP"]]}],"s":"MKSFSRILFLVFLLAGLRSKAAPSAPLPLGCGFPDMAHPSETSPLKGASENSKRDRLNPEFPGTPYPEPSKLPHTVSLETFPLDFTEPLNPDLRETPHPESPETPKADSLTTSISESLDMPKTNLSKMAHPESSETPTPGPTEMPHPGSPETPKPNFSKTSRPEFPETPNTDLMQTTPQESPEILQLNATEVSQAELPETSNTNPTKTPDPKSPEKHDLNSTETPNSEFLQALHPDPSKTPHPESHVTHNPSPTEISQTEFPTTYYQNATDVPRTSDPQISTSLYPETPVPFKDDATALNELSLNPKPGTPAAIQPDSPKLPTSDSPGMVELKAPQNSGPKESNVPPPSARIAGPPALPGRPSQLAPATLRAPQRHSRGEGVNTIIVVERVKETGVTLVGRPRGAAGGALCLFFAGTALLIGIFVLLWCLYRRAARQRPFAHHRLPDDGDEPVLHLDAPKDPYDLYFYAPDTWVPSHIATKQPPPTPPLPPKLPPPPRGGRPQRLEALSPATLPNNFV"},{"id":"SEQ_06927","a":"P56182","g":"RRP1","d":"Ribosomal RNA processing protein 1 homolog A","L":461,"m":[{"c":"ψAoRLφ(x){11,12}RK[LR][RL][KY][YK]ψψx+xQxφAGG(x){0,1}FxxDEψ","u":"40-42","sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved ~40-42 aa helix-turn-helix-like structural repeats near the N-terminus and central-C-terminal region sharing an N-terminal ψAoRLφ helix, a 11-12 aa linker, a basic amphipathic helix ending in an invariant AGG turn (RK[LR][RL][KY][YK]ψψx+xQxφAGG), and a C-terminal FxxDEψ motif.","i":[[13,52,"LAQRLAGNEQVTRDRAVRKLRKYIVARTQRAAGGFTHDEL"],[303,344,"VANRLFEMASRQSTPSQNRKRLYKVIRKLQDLAGGIFPEDEI"]]}],"s":"MVSRVQLPPEIQLAQRLAGNEQVTRDRAVRKLRKYIVARTQRAAGGFTHDELLKVWKGLFYCMWMQDKPLLQEELGRTISQLVHAFQTTEAQHLFLQAFWQTMNREWTGIDRLRLDKFYMLMRMVLNESLKVLKMQGWEERQIEELLELLMTEILHPSSQAPNGVKSHFIEIFLEELTKVGAEELTADQNLKFIDPFCRIAARTKDSLVLNNITRGIFETIVEQAPLAIEDLLNELDTQDEEVASDSDESSEGGERGDALSQKRSEKPPAGSICRAEPEAGEEQAGDDRDSGGPVLQFDYEAVANRLFEMASRQSTPSQNRKRLYKVIRKLQDLAGGIFPEDEIPEKACRRLLEGRRQKKTKKQKRLLRLQQERGKGEKEPPSPGMERKRSRRRGVGADPEARAEAGEQPGTAERALLRDQPRGRGQRGARQRRRTPRPLTSARAKAANVQEPEKKKKRRE"},{"id":"SEQ_06930","a":"Q9H0E3","g":"SAP130","d":"Histone deacetylase complex subunit SAP130","L":1048,"m":[{"c":"G[IL]QPAPψ[GS]T[QP]","u":10,"sp":"tandem","x":"disordered_like","cf":"high","why":"Tandem decapeptide repeat array in the central disordered region with invariant G1, Q3, P4, A5, P6, and T9 anchors and conserved aliphatic positions ([IL]2, ψ7); copies 1-3 are strictly head-to-tail and copy 4 immediately follows an 11-aa divergent repeat unit (GIHSATPINTQ).","i":[[560,569,"GIQPAPISTQ"],[570,579,"GIQPAPIGTP"],[580,589,"GIQPAPLGTQ"],[601,610,"GLQPAPMGTQ"]]}],"s":"MGPPRHPQAGEIEAGGAGGGRRLQVEMSSQQFPRLGAPSTGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTNLEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLDHKDRVLKLLNKNGTVKKVSKLKRKEKV"},{"id":"SEQ_06937","a":"P48552","g":"NRIP1","d":"Nuclear receptor-interacting protein 1","L":1158,"m":[{"c":"φLxxLL","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Seven dispersed copies of a short hydrophobic linear motif anchored by a leading bulky hydrophobic residue (L, V, or Y) and three invariant leucines in an LxxLL register, embedded within polar/Ser/Pro-enriched disordered sequence.","i":[[20,25,"YLEGLL"],[132,137,"LLASLL"],[379,384,"LLLHLL"],[500,505,"LLQLLL"],[712,717,"VLQLLL"],[818,823,"LLSRLL"],[935,940,"VLKQLL"]]}],"s":"MTHGEELGSDVHQDSIVLTYLEGLLMHQAAGGSGTAVDKKSAGHNEEDQNFNISGSAFPTCQSNGPVLNTHTYQGSGMLHLKKARLLQSSEDWNAAKRKRLSDSIMNLNVKKEALLAGMVDSVPKGKQDSTLLASLLQSFSSRLQTVALSQQIRQSLKEQGYALSHDSLKVEKDLRCYGVASSHLKTLLKKSKVKDQKPDTNLPDVTKNLIRDRFAESPHHVGQSGTKVMSEPLSCAARLQAVASMVEKRASPATSPKPSVACSQLALLLSSEAHLQQYSREHALKTQNANQAASERLAAMARLQENGQKDVGSYQLPKGMSSHLNGQARTSSSKLMASKSSATVFQNPMGIIPSSPKNAGYKNSLERNNIKQAANNSLLLHLLKSQTIPKPMNGHSHSERGSIFEESSTPTTIDEYSDNNPSFTDDSSGDESSYSNCVPIDLSCKHRTEKSESDQPVSLDNFTQSLLNTWDPKVPDVDIKEDQDTSKNSKLNSHQKVTLLQLLLGHKNEENVEKNTSPQGVHNDVSKFNTQNYARTSVIESPSTNRTTPVSTPPLLTSSKAGSPINLSQHSLVIKWNSPPYVCSTQSEKLTNTASNHSMDLTKSKDPPGEKPAQNEGAQNSATFSASKLLQNLAQCGMQSSMSVEEQRPSKQLLTGNTDKPIGMIDRLNSPLLSNKTNAVEENKAFSSQPTGPEPGLSGSEIENLLERRTVLQLLLGNPNKGKSEKKEKTPLRDESTQEHSERALSEQILMVKIKSEPCDDLQIPNTNVHLSHDAKSAPFLGMAPAVQRSAPALPVSEDFKSEPVSPQDFSFSKNGLLSRLLRQNQDSYLADDSDRSHRNNEMALLESKNLCMVPKKRKLYTEPLENPFKKMKNNIVDAANNHSAPEVLYGSLLNQEELKFSRNDLEFKYPAGHGSASESEHRSWARESKSFNVLKQLLLSENCVRDLSPHRSNSVADSKKKGHKNNVTNSKPEFSISSLNGLMYSSTQPSSCMDNRTFSYPGVVKTPVSPTFPEHLGCAGSRPESGLLNGCSMPSEKGPIKWVITDAEKNEYEKDSPRLTKTNPILYYMLQKGGNSVTSRETQDKDIWREASSAESVSQVTAKEELLPTAETKASFFNLRSPYNSHMGNNASRPHSANGEVYGLLGSVLTIKKESE"},{"id":"SEQ_06950","a":"Q9BXA9","g":"SALL3","d":"Sal-like protein 3","L":1300,"m":[{"c":"CxxCxxx[FLC]xxx[SGV][ANV]LxxHxxxH","u":21,"sp":"dispersed","x":"structured_like","cf":"high","why":"Nine conserved 21-aa C2H2 zinc-finger repeats defined by invariant CxxC and HxxxH coordination motifs and a fixed internal leucine, arranged in four dispersed clusters (eight of the nine forming four highly conserved TGE[RK]PF-linked finger pairs, plus one additional C-terminal finger in the second cluster).","i":[[422,442,"CRFCAKVFGSDSALQIHLRSH"],[450,470,"CNICGNRFSTKGNLKVHFQRH"],[681,701,"CVICHRVLSCQSALKMHYRTH"],[709,729,"CKICGRAFTTKGNLKTHFGVH"],[741,761,"CPICQKKFTNAVVLQQHIRMH"],[979,999,"CGVCGKPFACKSALEIHYRSH"],[1007,1027,"CALCRRGCSTMGNLKQHLLTH"],[1115,1135,"CQSCGKTFSSASALQIHERTH"],[1143,1163,"CTICGRAFTTKGNLKVHMGTH"]]}],"s":"MSRRKQAKPQHLKSDEELLPPDGAPEHAAPGEGAEDADSGPESRSGGEETSVCEKCCAEFFKWADFLEHQRSCTKLPPVLIVHEDAPAPPPEDFPEPSPASSPSERAESEAAEEAGAEGAEGEARPVEKEAEPMDAEPAGDTRAPRPPPAAPAPPTPAYGAPSTNVTLEALLSTKVAVAQFSQGARAAGGSGAGGGVAAAAVPLILEQLMALQQQQIHQLQLIEQIRSQVALMQRPPPRPSLSPAAAPSAPGPAPSQLPGLAALPLSAGAPAAAIAGSGPAAPAAFEGAQPLSRPESGASTPGGPAEPSAPAAPSAAPAPAAPAPAPAPQSAASSQPQSASTPPALAPGSLLGAAPGLPSPLLPQTSASGVIFPNPLVSIAATANALDPLSALMKHRKGKPPNVSVFEPKASAEDPFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNICGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEYLDNVPTCSGIPYGMSLPPEKPVTTWLDSKPVLPTVPTSVGLQLPPTVPGAHGYADSPSATPASRSPQRPSPASSECASLSPGLNHVESGVSATAESPQSLLGGPPLTKAEPVSLPCTNARAGDAPVGAQASAAPTSVDGAPTSLGSPGLPAVSEQFKAQFPFGGLLDSMQTSETSKLQQLVENIDKKMTDPNQCVICHRVLSCQSALKMHYRTHTGERPFKCKICGRAFTTKGNLKTHFGVHRAKPPLRVQHSCPICQKKFTNAVVLQQHIRMHMGGQIPNTPLPEGFQDAMDSELAYDDKNAETLSSYDDDMDENSMEDDAELKDAATDPAKPLLSYAGSCPPSPPSVISSIAALENQMKMIDSVMSCQQLTGLKSVENGSGESDRLSNDSSSAVGDLESRSAGSPALSESSSSQALSPAPSNGESFRSKSPGLGAPEEPQEIPLKTERPDSPAAAPGSGGAPGRAGIKEEAPFSLLFLSRERGKCPSTVCGVCGKPFACKSALEIHYRSHTKERPFVCALCRRGCSTMGNLKQHLLTHRLKELPSQLFDPNFALGPSQSTPSLISSAAPTMIKMEVNGHGKAMALGEGPPLPAGVQVPAGPQTVMGPGLAPMLAPPPRRTPKQHNCQSCGKTFSSASALQIHERTHTGEKPFGCTICGRAFTTKGNLKVHMGTHMWNNAPARRGRRLSVENPMALLGGDALKFSEMFQKDLAARAMNVDPSFWNQYAAAITNGLAMKNNEISVIQNGGIPQLPVSLGGSALPPLGSMASGMDKARTGSSPPIVSLDKASSETAASRPFTRFIEDNKEIGIN"},{"id":"SEQ_06952","a":"Q6W2J9","g":"BCOR","d":"BCL-6 corepressor","L":1755,"m":[{"c":"xxx[NQ][AD]GxxxL[HQ]xA[ACV]xx[DG][HWY][EL][EN][IV]V[LR]x[CL]L[ES](x){3,4}D[PV][NT]","u":"33-34","sp":"tandem","x":"structured_like","cf":"high","why":"Three head-to-tail 33-34 aa structural repeats near the C-terminus anchored by invariant G, L, A, V, L, and D positions alongside conserved [HQ], [IV]V, and C-terminal D[PV][NT] motifs, with a single-residue loop length difference in the first copy.","i":[[1458,1491,"VNKNAGETLLQRAARLGYEEVVLYCLENKICDVN"],[1492,1524,"HRDNAGYCALHEACARGWLNIVRHLLEYGADVN"],[1525,1557,"CSAQDGTRPLHDAVENDHLEIVRLLLSYGADPT"]]}],"s":"MLSATPLYGNVHSWMNSERVRMCGASEDRKILVNDGDASKARLELREENPLNHNVVDASTAHRIDGLAALSMDRTGLIREGLRVPGNIVYSSLCGLGSEKGREAATSTLGGLGFSSERNPEMQFKPNTPETVEASAVSGKPPNGFSAIYKTPPGIQKSAVATAEALGLDRPASDKQSPLNINGASYLRLPWVNPYMEGATPAIYPFLDSPNKYSLNMYKALLPQQSYSLAQPLYSPVCTNGERFLYLPPPHYVGPHIPSSLASPMRLSTPSASPAIPPLVHCADKSLPWKMGVSPGNPVDSHAYPHIQNSKQPRVPSAKAVTSGLPGDTALLLPPSPRPSPRVHLPTQPAADTYSEFHKHYARISTSPSVALSKPYMTVSSEFPAARLSNGKYPKAPEGGEGAQPVPGHARKTAVQDRKDGSSPPLLEKQTVTKDVTDKPLDLSSKVVDVDASKADHMKKMAPTVLVHSRAGSGLVLSGSEIPKETLSPPGNGCAIYRSEIISTAPSSWVVPGPSPNEENNGKSMSLKNKALDWAIPQQRSSSCPRMGGTDAVITNVSGSVSSAGRPASASPAPNANADGTKTSRSSVETTPSVIQHVGQPPATPAKHSSSTSSKGAKASNPEPSFKANENGLPPSSIFLSPNEAFRSPPIPYPRSYLPYPAPEGIAVSPLSLHGKGPVYPHPVLLPNGSLFPGHLAPKPGLPYGLPTGRPEFVTYQDALGLGMVHPMLIPHTPIEITKEEKPERRSRSHERARYEDPTLRNRFSEILETSSTKLHPDVPTDKNLKPNPNWNQGKTVVKSDKLVYVDLLREEPDAKTDTNVSKPSFAAESVGQSAEPPKPSVEPALQQHRDFIALREELGRISDFHETYTFKQPVFTVSKDSVLAGTNKENLGLPVSTPFLEPPLGSDGPAVTFGKTQEDPKPFCVGSAPPSVDVTPTYTKDGADEAESNDGKVLKPKPSKLAKRIANSAGYVGDRFKCVTTELYADSSQLSREQRALQMEGLQEDSILCLPAAYCERAMMRFSELEMKEREGGHPATKDSEMCKFSPADWERLKGNQDKKPKSVTLEEAIAEQNESERCEYSVGNKHRDPFEAPEDKDLPVEKYFVERQPVSEPPADQVASDMPHSPTLRVDRKRKVSGDSSHTETTAEEVPEDPLLKAKRRRVSKDDWPEREMTNSSSNHLEDPHYSELTNLKVCIELTGLHPKKQRHLLHLRERWEQQVSAADGKPGRQSRKEVTQATQPEAIPQGTNITEEKPGRKRAEAKGNRSWSEESLKPSDNEQGLPVFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAKQQKIKENQKTDVLCADEEEDCQAASLLQKYTDNSEKPSGKRLCKTKHLIPQESRRGLPLTGEYYVENADGKVTVRRFRKRPEPSSDYDLSPAKQEPKPFDRLQQLLPASQSTQLPCSSSPQETTQSRPMPPEARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDYLNDLQGRNDDDASGTWDFYGSSVCEPDDESGYDVLANPPGPEDQDDDDDAYSDVFEFEFSETPLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIFRCNFPNVEIVTIAEAEFYRQVSASLLFSCSKDLEAFNPESKELLDLVEFTNEIQTLLGSSVEWLHPSDLASDNYW"},{"id":"SEQ_06959","a":"A0A1B0GWB2","g":"PRRT1B","d":"Proline rich transmembrane protein 1B","L":263,"m":[{"c":"[AP][APS][ALQ]L[FY][PS][AP]","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four closely spaced copies in the central proline-rich disordered region centered on an invariant L followed by an aromatic [FY] anchor and flanked symmetrically by [AP]/[PS] proline-enriched positions.","i":[[115,121,"APLLYPP"],[133,139,"PSALFPP"],[140,146,"PAQLYPA"],[150,156,"PPALFSP"]]},{"c":"[KS][EP][AP][AT]PED[AP]xx[PQ]A","u":12,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three 12-aa copies in the N-terminal disordered tail (two head-to-tail tandem copies followed by a third copy 28 aa downstream) sharing an invariant PED core flanked by conserved [KS][EP][AP][AT] N-terminal and [PQ]A C-terminal positions.","i":[[17,28,"SPATPEDPRSPA"],[29,40,"KPAAPEDPQMPA"],[69,80,"SEPAPEDAPAQA"]]}],"s":"MEAGAGGAGSDTKGGGSPATPEDPRSPAKPAAPEDPQMPAQPALPQLPRRPRTLDEDGAPSEDGAAGGSEPAPEDAPAQAAGEAGPVSKAAAGGAPHIGFVGEPPPYAPPDPKAAPLLYPPFPQVPVVLQPAPSALFPPPAQLYPAAPTPPALFSPPAGAAFPFPVYNGPMAGVPGPATVEHRPLPKDYMMESVLVTLFCCLLTGLIAIVYSHEARAALGRGDLAQAEEASRKARSLVLFSLLFGVFVSTSWVIYVVVALYLP"},{"id":"SEQ_06969","a":"Q8NBJ4","g":"GOLM1","d":"Golgi membrane protein 1","L":401,"m":[{"c":"[EQ][EG]PxR-[QR][LV]","u":8,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 8-aa copies in the C-terminal disordered region (two nearly tandem separated by 1 aa and a third 36 aa downstream) anchored by invariant P3 and R5, conserved acidic D/E at position 6, aliphatic L/V at position 8, and constrained flanking polar/acidic choices.","i":[[263,270,"EEPQRDRL"],[272,279,"QEPGREQV"],[316,323,"EGPERDQL"]]}],"s":"MMGLGNGRRSMKSPPLVLAALVACIIVLGFNYWIASSRSVDLQTRIMELEGRVRRAAAERGAVELKKNEFQGELEKQREQLDKIQSSHNFQLESVNKLYQDEKAVLVNNITTGERLIRVLQDQLKTLQRNYGRLQQDVLQFQKNQTNLERKFSYDLSQCINQMKEVKEQCEERIEEVTKKGNEAVASRDLSENNDQRQQLQALSEPQPRLQAAGLPHTEVPQGKGNVLGNSKSQTPAPSSEVVLDSKRQVEKEETNEIQVVNEEPQRDRLPQEPGREQVVEDRPVGGRGFGGAGELGQTPQVQAALSVSQENPEMEGPERDQLVIPDGQEEEQEAAGEGRNQQKLRGEDDYNMDENEAESETDKQAALAGNDRNIDVFNVEDQKRDTINLLDQREKRNHTL"},{"id":"SEQ_06973","a":"Q5T7N3","g":"KANK4","d":"KN motif and ankyrin repeat domain-containing protein 4","L":995,"m":[{"c":"Gx[TS]A[LV]xφ(x){9,14}[VI]xxLL(x){12,13}","u":"33-38","sp":"tandem","x":"structured_like","cf":"high","why":"Five head-to-tail C-terminal repeats (33-38 aa, residues 824-995) anchored by an invariant Gx[TS]A[LV]xφ N-terminal motif and a conserved [VI]xxLL hydrophobic helix core, with a 5-residue loop insertion in the second copy. An independent central coiled-coil heptad tract (residues 349-400) is recorded in flags.","i":[[824,857,"GNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKA"],[858,895,"GYTAVMITPLASAETNEDMAVVWKLLREGNVNIQATQG"],[896,928,"GQTALMLGVSHDREDMVQALLSCQADVNLQDHD"],[929,962,"GSSALMVACHHGNVDLVRLLLAHPACDSSLTDKA"],[963,995,"GRTALSIALKSPTHMEIAGLLRAHAEQGRSLGL"]]}],"s":"MEKTDAKDQSSQGDEEKDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKQAKFSTLPRNFSLPDSGARPPAAPPLQNWSPVVPREASLGTQEQNQSPPLGNAPQASTSRSEVSYHRKALLAEATRQLEAAEPEDAELTFGSGRPQLLRASSMPATLLHSRASEEPGLSLGPPAPPALPPLQGEGSVCDGTFEPAEGLAGFHSSSPRASTRIPELVQEGAEPPEGVVKVPNHLPLPGPPFSFQNVLVVLEDKEDEHNAREAEVLFTPGSPTPSPPPLPSPIPENELLLEEIELNISEIPPPPPVEVDMRSIGIRVTEESLGLARVDPGSISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQFHQENAKDTQGQTDVMVNTDPVHGLLTRESCDKGIEVNLLGSMESESWGHRGEENGLLWGPDGHKQGNQSPAERVLLPQLSLPQGPEQVLTSSVHSFLSTELRIEEAGTEQEGGPQGGTRGAGGFLWGSDRKTPPAGREETSSNLPGKEHPGRPPSSPTDATIGQYVKKIQELLQEQWNCLEHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAHPPKEPPASSSSPPVEISPSTSLKSIMKKKDYGFRAGGNGTKKNLQFVGVNGGYETTSSEETSGEDSTPEDLSDSEAEKKCDGPDHKHVKDAHLTCEAGQGIPEGTCHAAQESGPGEEVPHSKAERYKPSEEFLNACRALSQHLPETGTTTDQLLRQSLNTISQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQGRSLGL"},{"id":"SEQ_06975","a":"O75038","g":"PLCH2","d":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2","L":1416,"m":[{"c":"QxψKQxFxEADx[ND]xxxxxxxxExφxφφxKψ","u":30,"sp":"periodic","x":"structured_like","cf":"high","why":"Paired 30-aa helix-loop-helix duplication (residues 172-201 and 208-237, separated by a 6-aa linker) sharing 9 identical anchor residues (Q, K, Q, F, E, A, D, E, K) and 5 conserved hydrophobic positions across both helices.","i":[[172,201,"QWLKQTFDEADKNGDGSLSIGEVLQLLHKL"],[208,237,"QRVKQMFREADTDDHQGTLGFEEFCAFYKM"]]}],"s":"MSGPWPSPDSRTKGTVAWLAEVLLWVGGSVVLSSEWQLGPLVERCMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSEGRQSEVFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLDSLIKESKIRDCEDPNNFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSKLKKAASVEEGDEGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDIEMEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQGVFNPNSEDPLPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWEETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQALGLKGLFLRGPKPGSLDSHAAGRPPARPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKGVADDVVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPAAVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSDPLWQRLEPCGHRDSVSSSSSMSSSDTVIDLSLPSLGLGRSRENLAGAHMGRLPPRPHSASAARPDLPPVTKSKSNPNLRATGQRPPIPDELQPRSLAPRMAGLPFRPPWGCLSLVGVQDCPVAAKSKSLGDLTADDFAPSFEGGSRRLSHSLGLPGGTRRVSGPGVRRDTLTEQLRWLTVFQQAGDITSPTSLGPAGEGVAGGPGFVRRSSSRSHSRVRAIASRARQAQERQQRLQGLGRQGPPEEERGTPEGACSVGHEGSVDAPAPSKGALGPASAAAENLVLLRL"},{"id":"SEQ_06980","a":"Q96KG9","g":"SCYL1","d":"N-terminal kinase-like protein","L":808,"m":[{"c":"(x){7,9}ψφPxφφ(x){13,16}ψxxφxxxL","u":"37-40","sp":"tandem","x":"structured_like","cf":"high","why":"Six contiguous head-to-tail 37-40 aa alpha-helical repeats spanning residues 305-537, anchored by a conserved N-helical hydrophobic-proline core (ψφPxφφ), an inter-helical Asp/Pro turn, C-helical hydrophobics, and an invariant C-terminal Leu.","i":[[305,341,"PEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFL"],[342,380,"SAEEYQQKIIPVVVKMFSSTDRAMRIRLLQQMEQFIQYL"],[381,419,"DEPTVNTQIFPHVVHGFLDTNPAIREQTVKSMLLLAPKL"],[420,459,"NEANLNVELMKHFARLQAKDEQGPIRCNTTVCLGKIGSYL"],[460,497,"SASTRHRVLTSAFSRATRDPFAPSRVAGVLGFAATHNL"],[498,537,"YSMNDCAQKILPVLCGLTVDPEKSVRDQAFKAIRSFLSKL"]]},{"c":"[DES]xWxx","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Six non-overlapping 5-aa acidic/polar Trp motifs (including two immediate head-to-tail pairs, DRWDD+EDWGS and DSWGE+DNWEG) dispersed across the C-terminal disordered tail (residues 642-762), anchored by a leading D/E/S, an invariant Trp, and small polar/acidic/Gly flanking residues.","i":[[642,646,"DRWDD"],[647,651,"EDWGS"],[664,668,"DDWST"],[691,695,"SDWSS"],[753,757,"DSWGE"],[758,762,"DNWEG"]]}],"s":"MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPELEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSSTDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKSMLLLAPKLNEANLNVELMKHFARLQAKDEQGPIRCNTTVCLGKIGSYLSASTRHRVLTSAFSRATRDPFAPSRVAGVLGFAATHNLYSMNDCAQKILPVLCGLTVDPEKSVRDQAFKAIRSFLSKLESVSEDPTQLEEVEKDVHAASSPGMGGAAASWAGWAVTGVSSLTSKLIRSHPTTAPTETNIPQRPTPEGVPAPAPTPVPATPTTSGHWETQEEDKDTAEDSSTADRWDDEDWGSLEQEAESVLAQQDDWSTGGQVSRASQVSNSDHKSSKSPESDWSSWEAEGSWEQGWQEPSSQEPPPDGTRLASEYNWGGPESSDKGDPFATLSARPSTQPRPDSWGEDNWEGLETDSRQVKAELARKKREERRREMEAKRAERKVAKGPMKLGARKLD"},{"id":"SEQ_06985","a":"Q96ME7","g":"ZNF512","d":"Zinc finger protein 512","L":567,"m":[{"c":"φxC(x){2,4}C(x){8,9}GφxxHψ(x){2,3}[HC]","u":"24-25","sp":"dispersed","x":"structured_like","cf":"high","why":"Six 24-25 aa C2H2/C2HC zinc-finger repeats arranged in three dispersed pairs (each pairing a C2HC unit with a C2H2 unit across residues 169-463), sharing invariant Cys2/His-[His/Cys] chelating anchors, a leading hydrophobic residue, and a conserved GφxxHψ core.","i":[[169,192,"VSCPTCQAVGRKTIEGLKKHMENC"],[197,220,"FTCHHCGKQLRSLAGMKYHVMANH"],[251,275,"LRCMRESCSSSFTSIMGYLYHVRKC"],[287,310,"LKCHHCGKPYRSKAGLAYHLRSEH"],[406,430,"IQCPNQGCEAVYSSVSGLKAHLGSC"],[440,463,"YKCLLCQKEFVSESGVKYHINSVH"]]}],"s":"MSSRLGAVPATSGPTTFKQQRSTRIVGAKNSRTQCSIKDNSFQYTIPHDDSLSGSSSASSCEPVSDFPASFRKSTYWMKMRRIKPAATSHVEGSGGVSAKGKRKPRQEEDEDYREFPQKKHKLYGRKQRPKTQPNPKSQARRIRKEPPVYAAGSLEEQWYLEIVDKGSVSCPTCQAVGRKTIEGLKKHMENCKQEMFTCHHCGKQLRSLAGMKYHVMANHNSLPILKAGDEIDEPSERERLRTVLKRLGKLRCMRESCSSSFTSIMGYLYHVRKCGKGAAELEKMTLKCHHCGKPYRSKAGLAYHLRSEHGPISFFPESGQPECLKEMNLESKSGGRVQRRSAKIAVYHLQELASAELAKEWPKRKVLQDLVPDDRKLKYTRPGLPTFSQEVLHKWKTDIKKYHRIQCPNQGCEAVYSSVSGLKAHLGSCTLGNFVAGKYKCLLCQKEFVSESGVKYHINSVHAEDWFVVNPTTTKSFEKLMKIKQRQQEEEKRRQQHRSRRSLRRRQQPGIELPETELSLRVGKDQRRNNEELVVSASCKEPEQEPVPAQFQKVKPPKTNHKRGRK"},{"id":"SEQ_06986","a":"O95206","g":"PCDH8","d":"Protocadherin-8","L":1070,"m":[{"c":"xxxφx(x){4,7}Gxφφxxφ(x){3,6}DxDxGxNGxxφxxφ(x){18,31}[LD]xE(x){5,8}LxφxxD[GR]GxPP(x){6,7}φxVxVxDxND[HN][AS]Pxxx","u":"94-110","sp":"tandem","x":"structured_like","cf":"high","why":"Six ~94-110 aa extracellular beta-sandwich-like repeats anchored by conserved DxDxGxNGxxφxxφ, [LD]xE, D[GR]GxPP, and C-terminal φxVxVxDxND[HN][AS]P motifs (the sixth membrane-proximal copy lacks the terminal DxNDxAP segment). Copies 1-3 and 4-6 pack essentially head-to-tail with a 42-aa A/P/G-rich linker separating copies 3 and 4.","i":[[34,136,"YSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFP"],[140,246,"IPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFP"],[250,355,"VAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIA"],[398,498,"TSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFT"],[501,610,"VYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLV"],[618,711,"SLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVT"]]}],"s":"MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGASAPGSPEEAARGAGPRPNMFDVLTFPGTGKAPFGSPAADAPPPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAPPVAVWKGHSFNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGHSDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEKVLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV"},{"id":"SEQ_06989","a":"P98095","g":"FBLN2","d":"Fibulin-2","L":1184,"m":[{"c":"[DQ]x[ND][ET]C(x){4,7}C(x){3,5}Cx[NT]xxGSφxC(x){1,6}C(x){2,3}[GN]Ω(x){6,8}C","u":"38-47","sp":"tandem","x":"structured_like","cf":"high","why":"Ten 6-cysteine repeats anchored by an N-terminal [DQ]x[ND][ET]C motif, an invariant-length Cx[NT]xxGSφxC core, and a C-terminal C(x){2,3}[GN]Ω(x){6,8}C loop. Copies 2-10 are arranged in tandem with 1-aa junctions following a 34-aa P/Q-rich linker after copy 1.","i":[[604,644,"DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTC"],[679,717,"QPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSC"],[719,762,"DINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGEC"],[764,808,"DVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNC"],[810,856,"DINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKC"],[858,899,"DVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGC"],[901,941,"DVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRC"],[943,980,"DVNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTC"],[982,1023,"DIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSC"],[1025,1068,"DVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKC"]]},{"c":"P[PE]L(x){1,2}NCIE[EA][AV]φ(x){4,5}CxxCxxxGCxx[EA]G[YH][QK]Y[YA](x){12,26}CxCPxxGGxφxC[QY][FQ]ψx(x){0,1}C","u":"63-76","sp":"tandem","x":"structured_like","cf":"high","why":"Two head-to-tail N-terminal cysteine-rich domain repeats sharing a 33-aa P[PE]L(x){1,2}NCIE...CxxCxxxGCxx[EA]G[YH][QK]Y[YA] N-terminal core and a C-terminal CxCPxxGGxφxC[QY][FQ]ψx(x){0,1}C subdomain.","i":[[39,114,"PPLENCIEEALEPGACCATCVQQGCACEGYQYYDCLQGGFVRGRVPAGQSYFVDFGSTECSCPPGGGKISCQFMLC"],[115,177,"PELPPNCIEAVVVADSCPQCGQVGCVHAGHKYAAGHTVHLPPCRACHCPDAGGELICYQLPGC"]]}],"s":"MVLLWEPAGAWLALGLALALGPSVAAAAPRQDCTGVECPPLENCIEEALEPGACCATCVQQGCACEGYQYYDCLQGGFVRGRVPAGQSYFVDFGSTECSCPPGGGKISCQFMLCPELPPNCIEAVVVADSCPQCGQVGCVHAGHKYAAGHTVHLPPCRACHCPDAGGELICYQLPGCHGNFSDAEEGDPERHYEDPYSYDQEVAEVEAATALGGEVQAGAVQAGAGGPPAALGGGSQPLSTIQAPPWPAVLPRPTAAAALGPPAPVQAKARRVTEDSEEEEEEEEEREEMAVTEQLAAGGHRGLDGLPTTAPAGPSLPIQEERAEAGARAEAGARPEENLILDAQATSRSTGPEGVTHAPSLGKAALVPTQAVPGSPRDPVKPSPHNILSTSLPDAAWIPPTREVPRKPQVLPHSHVEEDTDPNSVHSIPRSSPEGSTKDLIETCCAAGQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSCMAGVLGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQNSPARITHYQLNFQTGLLVPAHIFRIGPAPAFTGDTIALNIIKGNEEGYFGTRRLNAYTGVVYLQRAVLEPRDFALDVEMKLWRQGSVTTFLAKMHIFFTTFAL"},{"id":"SEQ_06990","a":"Q9NR30","g":"DDX21","d":"Nucleolar RNA helicase 2","L":783,"m":[{"c":"[GR][FP]RGQR[DES]G[GSN][RG]","u":10,"sp":"tandem","x":"disordered_like","cf":"high","why":"Four head-to-tail 10-aa repeats in the C-terminal R/G-rich disordered tail anchored by an invariant RGQRxG core, with copies 1-3 conserving the tighter [GR]FRGQR-G[SN]R motif and copy 4 forming a degenerate C-terminal unit.","i":[[723,732,"GFRGQREGSR"],[733,742,"GFRGQRDGNR"],[743,752,"RFRGQREGSR"],[753,762,"GPRGQRSGGG"]]},{"c":"[FS][PS]K[AST]K[KQS]φ[KRT]K[KN][AEK]EP[SI][EQ]x[DEK]ψ","u":18,"sp":"tandem","x":"disordered_like","cf":"high","why":"Four tandem 18-aa repeats (separated by 0-1 aa) in the N-terminal K/E/P/S-rich disordered region sharing invariant K (positions 3, 5, 9) and EP (positions 12-13) anchors alongside conserved internal hydrophobic (φ) and C-terminal aliphatic (ψ) positions, followed by a divergent partial fifth copy (APKPKKMKKEKE...).","i":[[52,69,"FPKAKQVKKKAEPSEVDM"],[71,88,"SPKSKKAKKKEEPSQNDI"],[89,106,"SPKTKSLRKKKEPIEKKV"],[108,125,"SSKTKKVTKNEEPSEEEI"]]}],"s":"MPGKLRSDAGLESDTAMKKGETLRKQTEEKEKKEKPKSDKTEEIAEEEETVFPKAKQVKKKAEPSEVDMNSPKSKKAKKKEEPSQNDISPKTKSLRKKKEPIEKKVVSSKTKKVTKNEEPSEEEIDAPKPKKMKKEKEMNGETREKSPKLKNGFPHPEPDCNPSEAASEESNSEIEQEIPVEQKEGAFSNFPISEETIKLLKGRGVTFLFPIQAKTFHHVYSGKDLIAQARTGTGKTFSFAIPLIEKLHGELQDRKRGRAPQVLVLAPTRELANQVSKDFSDITKKLSVACFYGGTPYGGQFERMRNGIDILVGTPGRIKDHIQNGKLDLTKLKHVVLDEVDQMLDMGFADQVEEILSVAYKKDSEDNPQTLLFSATCPHWVFNVAKKYMKSTYEQVDLIGKKTQKTAITVEHLAIKCHWTQRAAVIGDVIRVYSGHQGRTIIFCETKKEAQELSQNSAIKQDAQSLHGDIPQKQREITLKGFRNGSFGVLVATNVAARGLDIPEVDLVIQSSPPKDVESYIHRSGRTGRAGRTGVCICFYQHKEEYQLVQVEQKAGIKFKRIGVPSATEIIKASSKDAIRLLDSVPPTAISHFKQSAEKLIEEKGAVEALAAALAHISGATSVDQRSLINSNVGFVTMILQCSIEMPNISYAWKELKEQLGEEIDSKVKGMVFLKGKLGVCFDVPTASVTEIQEKWHDSRRWQLSVATEQPELEGPREGYGGFRGQREGSRGFRGQRDGNRRFRGQREGSRGPRGQRSGGGNKSNRSQNKGQKRSFSKAFGQ"},{"id":"SEQ_06992","a":"Q07889","g":"SOS1","d":"Son of sevenless homolog 1","L":1333,"m":[{"c":"[PG]P[PAL]ψPPR[QRE]","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed copies in the proline/serine-rich C-terminal disordered region (aa 1150-1296) share an invariant PxxPPR core with a conserved large aliphatic residue (V/I/L) at position 4, an N-terminal [PG]P cap, and a polar/charged [QRE] C-terminal residue.","i":[[1150,1157,"PPPVPPRR"],[1179,1186,"PPAIPPRQ"],[1211,1218,"PPLLPPRE"],[1289,1296,"GPPVPPRQ"]]}],"s":"MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDVEDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSANDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYARDILRPGFHDRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRLPGASNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAPNSPRTPLTPPPASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQVTLPHGPRSASVSSISLTKGTDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISDRTSISDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPPPQTPSPHGTRRHLPSPPLTQEVDLHSIAGPPVPPRQSTSQHIPKLPPKTYKREHTHPSMHRDGPPLLENAHSS"},{"id":"SEQ_06993","a":"O94993","g":"SOX30","d":"Transcription factor SOX-30","L":753,"m":[{"c":"AxxRLLQφ+P-xxLL[LQ]P","u":17,"sp":"dispersed","x":"mixed","cf":"high","why":"Two strongly conserved 17-aa copies in the N-terminal region (aa 66-113, separated by a 14-aa polar/alanine-rich linker) share 9 identical anchor positions (A, RLLQ, P, LL, P) and a conserved central φ+P- turn motif (VKPE/FRPD).","i":[[66,82,"AVRRLLQVKPEQVLLLP"],[96,112,"AQARLLQFRPDLRLLQP"]]},{"c":"PSxxIxxxxVPLT[PV]ψP[ST]","u":17,"sp":"dispersed","x":"mixed","cf":"medium","why":"Two closely spaced 17-aa copies separated by a 7-aa linker (aa 280-320) share N-terminal PSxxI anchors and a highly conserved C-terminal VPLT[PV]ψP[ST] block (with a divergent IPLTLHTVPP vestige 19 aa upstream).","i":[[280,296,"PSELIRLTKVPLTPVPT"],[304,320,"PSVKIETKDVPLTVLPS"]]}],"s":"MERARPEPPPQPRPLRPAPPPLPVEGTSFWAAAMEPPPSSPTLSAAASATLASSCGEAVASGLQPAVRRLLQVKPEQVLLLPQPQAQNEEAAASSAQARLLQFRPDLRLLQPPTASDGATSRPELHPVQPLALHVKAKKQKLGPSLDQSVGPRGAVETGPRASRVVKLEGPGPALGYFRGDEKGKLEAEEVMRDSMQGGAGKSPAAIREGVIKTEEPERLLEDCRLGAEPASNGLVHGSAEVILAPTSGAFGPHQQDLRIPLTLHTVPPGARIQFQGAPPSELIRLTKVPLTPVPTKMQSLLEPSVKIETKDVPLTVLPSDAGIPDTPFSKDRNGHVKRPMNAFMVWARIHRPALAKANPAANNAEISVQLGLEWNKLSEEQKKPYYDEAQKIKEKHREEFPGWVYQPRPGKRKRFPLSVSNVFSGTTQNIISTNPTTVYPYRSPTYSVVIPSLQNPITHPVGETSPAIQLPTPAVQSPSPVTLFQPSVSSAAQVAVQDPSLPVYPALPPQRFTGPSQTDTHQLHSEATHTVKQPTPVSLESANRISSSASTAHARFATSTIQPPREYSSVSPCPRSAPIPQASPIPHPHVYQPPPLGHPATLFGTPPRFSFHHPYFLPGPHYFPSSTCPYSRPPFGYGNFPSSMPECLSYYEDRYPKHEGIFSTLNRDYSFRDYSSECTHSENSRSCENMNGTSYYNSHSHSGEENLNPVPQLDIGTLENVFTAPTSTPSSIQQVNVTDSDEEEEEKVLRDL"},{"id":"SEQ_07006","a":"O43432","g":"EIF4G3","d":"Eukaryotic translation initiation factor 4 gamma 3","L":1585,"m":[{"c":"x[PQF]Yxx[PQ][PQG]","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Six closely spaced 7-aa repeats clustered in the N-terminal P/Q/G/Y-rich disordered region (residues 56-117, separated by 0-10 aa linkers), anchored by an invariant central Tyr, constrained [PQF] at position 2, predominant Pro at positions 1 and 4 (4/6 copies each), and C-terminal [PQ][PQG].","i":[[56,62,"MPYPVPQ"],[64,70,"PQYCIPQ"],[76,82,"PPYVGPP"],[83,89,"QQYPVQP"],[94,100,"PFYPGPG"],[111,117,"PFYPSQP"]]}],"s":"MNSQPQTRSPFFQRPQIQPPRATIPNSSPSIRPGAQTPTAVYQANQHIMMVNHLPMPYPVPQGPQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGDFPNAYGTPFYPSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEIMSGGGSRNPTPPIGRPTSTPTPPQQLPSQVPEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVLKSPSPVLRLVLSGEKKEQEGQTSETTAIVSIAELPLPPSPTTVSSVARSTIAAPTSSALSSQPIFTTAIDDRCELSSPREDTIPIPSLTSCTETSDPLPTNENDDDICKKPCSVAPNDIPLVSSTNLINEINGVSEKLSATESIVEIVKQEVLPLTLELEILENPPEEMKLECIPAPITPSTVPSFPPTPPTPPASPPHTPVIVPAAATTVSSPSAAITVQRVLEEDESIRTCLSEDAKEIQNKIEVEADGQTEEILDSQNLNSRRSPVPAQIAITVPKTWKKPKDRTRTTEEMLEAELELKAEEELSIDKVLESEQDKMSQGFHPERDPSDLKKVKAVEENGEEAEPVRNGAESVSEGEGIDANSGSTDSSGDGVTFPFKPESWKPTDTEGKKQYDREFLLDFQFMPACIQKPEGLPPISDVVLDKINQPKLPMRTLDPRILPRGPDFTPAFADFGRQTPGGRGVPLLNVGSRRSQPGQRREPRKIITVSVKEDVHLKKAENAWKPSQKRDSQADDPENIKTQELFRKVRSILNKLTPQMFNQLMKQVSGLTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLKVPMADKPGNTVNFRKLLLNRCQKEFEKDKADDDVFEKKQKELEAASAPEERTRLHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKTSSRIRFMLQDVIDLRLCNWVSRRADQGPKTIEQIHKEAKIEEQEEQRKVQQLMTKEKRRPGVQRVDEGGWNTVQGAKNSRVLDPSKFLKITKPTIDEKIQLVPKAQLGSWGKGSSGGAKASETDALRSSASSLNRFSALQPPAPSGSTPSTPVEFDSRRTLTSRGSMGREKNDKPLPSATARPNTFMRGGSSKDLLDNQSQEEQRREMLETVKQLTGGVDVERNSTEAERNKTRESAKPEISAMSAHDKAALSEEELERKSKSIIDEFLHINDFKEAMQCVEELNAQGLLHVFVRVGVESTLERSQITRDHMGQLLYQLVQSEKLSKQDFFKGFSETLELADDMAIDIPHIWLYLAELVTPMLKEGGISMRELTIEFSKPLLPVGRAGVLLSEILHLLCKQMSHKKVGALWREADLSWKDFLPEGEDVHNFLLEQKLDFIESDSPCSSEALSKKELSAEELYKRLEKLIIEDKANDEQIFDWVEANLDEIQMSSPTFLRALMTAVCKAAIIADSSTFRVDTAVIKQRVPILLKYLDSDTEKELQALYALQASIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKDPAEQNGKGVALKSVTAFFTWLREAEEESEDN"},{"id":"SEQ_07007","a":"Q96D09","g":"GPRASP2","d":"G protein-coupled receptor-associated sorting protein 2","L":838,"m":[{"c":"R[PS]K[TVD][EDR][ATV][QKR]xxx[GAQ][AS]","u":12,"sp":"tandem","x":"disordered_like","cf":"high","why":"Head-to-tail 8-copy tandem array of 12-residue units in the N-terminal disordered region anchored by invariant R1 and K3, conserved [PS]2, acidic/charged positions 4-7, and a C-terminal GA-like dipeptide.","i":[[37,48,"RPKVRTQATTGA"],[49,60,"RPKTETKSVPAA"],[61,72,"RPKTEAQAMSGA"],[73,84,"RPKTEVQVMGGA"],[85,96,"RPKTEAQGITGA"],[97,108,"RPKTDARAVGGA"],[109,120,"RSKTDAKAIPGA"],[121,132,"RPKDEAQAWAQS"]]},{"c":"EE[EG][AV]IxGS[WA]ΩW[AD][ER]x[EK][AS][SC]φ","u":18,"sp":"periodic","x":"disordered_like","cf":"high","why":"Three 18-residue repeats separated by regular 14-aa and 12-aa linkers, strongly anchored by an N-terminal EE[EG][AV]I tract, invariant GS and ΩW aromatic core, and a C-terminal hydrophobic residue.","i":[[382,399,"EEEVIIGSWFWAEKEASL"],[414,431,"EEGAIGGSAYWAEEKSSL"],[444,461,"EEEAIFGSWFWDRDEACF"]]},{"c":"[SF]RPRx+[EQ]EAxxxS","u":13,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 13-residue motifs in the central disordered region sharing an invariant RPR core, a conserved basic residue (+6), [EQ]EA triad, and C-terminal S.","i":[[210,222,"SRPRAREEASNES"],[268,280,"SRPRSKQEAYVDS"],[304,316,"FRPRVREEANIRS"]]},{"c":"[GS]FW[STV][GA]-[EN]To","u":9,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three non-overlapping 9-residue aromatic-acidic motifs in the central disordered region anchored by an invariant FW dipeptide, acidic position 6, invariant T8, and polar uncharged C-terminal residue.","i":[[223,231,"GFWSADETS"],[235,243,"SFWTGEETS"],[293,301,"SFWVGENTN"]]}],"s":"MTGAEIEPSAQAKPEKKAGEEVIAGPERENDVPLVVRPKVRTQATTGARPKTETKSVPAARPKTEAQAMSGARPKTEVQVMGGARPKTEAQGITGARPKTDARAVGGARSKTDAKAIPGARPKDEAQAWAQSEFGTEAVSQAEGVSQTNAVAWPLATAESGSVTKSKGLSMDRELVNVDAETFPGTQGQKGIQPWFGPGEETNMGSWCYSRPRAREEASNESGFWSADETSTASSFWTGEETSVRSWPREESNTRSRHRAKHQTNPRSRPRSKQEAYVDSWSGSEDEASNPFSFWVGENTNNLFRPRVREEANIRSKLRTNREDCFESESEDEFYKQSWVLPGEEANSRFRHRDKEDPNTALKLRAQKDVDSDRVKQEPRFEEEVIIGSWFWAEKEASLEGGASAICESEPGTEEGAIGGSAYWAEEKSSLGAVAREEAKPESEEEAIFGSWFWDRDEACFDLNPCPVYKVSDRFRDAAEELNASSRPQTWDEVTVEFKPGLFHGVGFRSTSPFGIPEEASEMLEAKPKNLELSPEGEEQESLLQPDQPSPEFTFQYDPSYRSVREIREHLRARESAESESWSCSCIQCELKIGSEEFEEFLLLMDKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIHMAPPYPNLNMIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGFLSLLTTANARTKFHVLKMLLNLSENPAVAKKLFSAKALSIFVGLFNIEETNDNIQIVIKMFQNISNIIKSGKMSLIDDDFSLEPLISAFREFEELAKQLQAQIDNQNDPEVGQQS"},{"id":"SEQ_07016","a":"O15050","g":"TRANK1","d":"TPR and ankyrin repeat-containing protein 1","L":2925,"m":[{"c":"Gx[TY][PVL]ψHφφφ(x){13,17}φL(x){5,11}[NT]xx[DEL]","u":"33-39","sp":"dispersed","x":"structured_like","cf":"high","why":"Four structured 33-39 aa repeats organized as two near-tandem pairs (residues 200-278 and 498-579) sharing an invariant G at position 1 and H at position 6 within a conserved N-terminal Gx[TY][PVL]ψHφφφ signature, an internal φL hydrophobic doublet, and a C-terminal [NT]xx[DEL] turn.","i":[[200,238,"GPYPLHALMRLCIQARENHLFRWLMDHKPEWKGRINQKD"],[241,278,"GCTVLHVVAAHSPGYLVKRQTEDVQMLLRFGADPTLLD"],[498,534,"GDTPLHAALHIFLEIKADIGFSFLSHLLDLFWSNPTE"],[547,579,"GNTLMHILFQKGMLKRVKKLLDLLVKFDINFNL"]]},{"c":"φx-A[ALF](x){11,18}[AT](x){9,22}","u":"26-39","sp":"tandem","x":"structured_like","cf":"high","why":"Seven contiguous head-to-tail 26-39 aa amphipathic two-helix repeats spanning residues 1796-2036, anchored by a strictly conserved N-terminal φx-A[ALF] motif (predominantly φx-AA) in the first helix and a small [AT] core position in the second helix.","i":[[1796,1834,"IRDAAYFYKRSQCYKDAFRCFEQIQEFDLALKMYCQEEL"],[1835,1866,"FEEAAIAVEKYEEMLKTKTLPISKLSYSASQF"],[1867,1904,"YLEAAAKYLSANKMKEMMAVLSKLDIEDQLVFLKSRKR"],[1905,1930,"LAEAADLLNREGRREEAALLMKQHGC"],[1931,1968,"LLEAARLTADKDFQASCLLGAARLNVARDSDIEHTKDI"],[1969,2001,"LREALDICYQTGQLSGIAEAHFLQGVILRDFQK"],[2002,2036,"LRDAFFKFDTLNHSAGVVEALYEAASQCEAEPEKI"]]}],"s":"MWDPRAARVPPRDLAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTYVKGYYRAGYSLLRLHQPYEAARMFFEGLRLVQRSQDQAPVADFLVGVFTTMSSDSIVLQSFLPCFDHIFTTGFPTEVWQSVIEKLAKKGLWHSFLLLSAKKDRLPRNIHVPELSLKSLFEKYVFIGLYEKMEQVPKLVQWLISIGASVETIGPYPLHALMRLCIQARENHLFRWLMDHKPEWKGRINQKDGDGCTVLHVVAAHSPGYLVKRQTEDVQMLLRFGADPTLLDRQSRSVVDVLKRNKNFKAIEKINSHLEKLATCSKDLSGFSNGDGPTSENDIFRKVLEQLVKYMNSGNRLLHKNFLKQEVVQRFLRLLSTLQEIPPDLVCDINQDCATTVFKFLLEKQRWPEVLLLLTRKVSGEPPLGDCLIKDCNFSDLDICTIIPHLSTWDQRKKQLLGCLIDSGALPDGLQESQERPVVTCLKHEDFELAFLLLTKGADPRAISLTEGDTPLHAALHIFLEIKADIGFSFLSHLLDLFWSNPTEFDYLNPNVQDSNGNTLMHILFQKGMLKRVKKLLDLLVKFDINFNLKNKEGKDARHRIKKNDSLLLAWNKALMENRRRSRQDSAAHLGKLSKSTAPGHTSQLKSQGSFKSVPCGATARTLPEGSAVPDSWETLPGTQVTRKEPGALRPCSLRDCLMQDITVLIQQVEVDPSFPEDCLQSSEPLEAGAGKEGKKDDKPTLGAGAPDCSEVGEGHAQVGLGALQLVPDDNRGKEGNDDQDDWSTQEIEACLQDFDNMTWEIECTSEMLKKLSSKVMTKVIKKKIILAIQQLGNGEWTQGLQKRLKHLKGSIQLFEAKLDKGARMLWELAIDFSPRCSENPEKIIATEQNTCAMEKSGRIYTEIIRIWDIVLDHCKLADSIKAICNAYNRGLSCVLRKKLKGINKGQVSANMKIQKRIPRCYVEDTEAEKGREHVNPEYFPPASAVETEYNIMKFHSFSTNMAFNILNDTTATVEYPFRVGELEYAVIDLNPRPLEPIILIGRSGTGKTTCCLYRLWKKFHVYWEKAEQAGSPLLAKQVWLKRRLEVEPGKESPGGEEEEEEEDEEEEDSIEVETVESIDEQEYEACAGGAGVEPAGDGQAAEVCAPEHPHQLEHLHQIFVTKNHVLCQEVQRNFIELSKSTKATSHYKPLDPNIHKLQDLRDENFPLFVTSKQLLLLLDASLPKPFFLRNEDGSLKRTIIGWSAQEESTIPSWQEDEEEAEVDGDYSEEDKAVEMRTGDSDPRVYVTFEVFKNEIWPKMTKGRTAYNPALIWKEIKSFLKGSFEALSCPHGRLTEEVYKKLGRKRCPNFKEDRSEIYSLFSLYQQIRSQKGYFDEEDVLYNISRRLSKLRVLPWSIHELYGDEIQDFTQAELALLMKCINDPNSMFLTGDTAQSIMKGVAFRFSDLRSLFHYASRNTIDKQCAVRKPKKIHQLYQNYRSHSGILNLASGVVDLLQFYFPESFDRLPRDSGLFDGPKPTVLESCSVSDLAILLRGNKRKTQPIEFGAHQVILVANETAKEKIPEELGLALVLTIYEAKGLEFDDVLLYNFFTDSEAYKEWKIISSFTPTSTDSREENRPLVEVPLDKPGSSQGRSLMVNPEMYKLLNGELKQLYTAITRARVNLWIFDENREKRAPAFKYFIRRDFVQVVKTDENKDFDDSMFVKTSTPAEWIAQGDYYAKHQCWKVAAKCYQKGGAFEKEKLALAHDTALSMKSKKVSPKEKQLEYLELAKTYLECKEPTLSLKCLSYAKEFQLSAQLCERLGKIRDAAYFYKRSQCYKDAFRCFEQIQEFDLALKMYCQEELFEEAAIAVEKYEEMLKTKTLPISKLSYSASQFYLEAAAKYLSANKMKEMMAVLSKLDIEDQLVFLKSRKRLAEAADLLNREGRREEAALLMKQHGCLLEAARLTADKDFQASCLLGAARLNVARDSDIEHTKDILREALDICYQTGQLSGIAEAHFLQGVILRDFQKLRDAFFKFDTLNHSAGVVEALYEAASQCEAEPEKILGLAPGGLEILLSLVRALKRVTNNAEKEMVKSCFEFFGISQVDAKYCQIAQNDPGPILRIIFDLDLNLREKKTKDHFLIMTDQVKLALNKHLLGRLCQITRSLLGKTYRGVCMRFIVGLKCEDENCEHFHRPLRRCEAKCLVQSKMNLVAINGLLLEAKKVFPKILAEELKEIDYILSTDMYGLCKSILDVLFPKHFHQRVLSENPMACKEILKPNYKSFRFYRFALKEYIHFLFENESARNRRESTDLWLSAMQAFLLSSNYPEEFEKLLHQEEDNYNRELKALESEKDERGRGRGSRIKGIEGKFGMLAPNRDDENMDKTHLCFIRLLENCIDQFYVYRNPEDYKRLFFRFMNVLIKRCKEPLIPSIGNTVALLEFQFIHCGVVLARLWKNVILCLPKSYIALLHYWEFLFSKKDKELGDVFSIIQEYKPKDVTRAIQDFRFHLSYLAKVLCGYENVNFNVLLDAFSEIDYVVSGEAERTLVLCLVMLVNAEEILQPYCKPLLYRHFREIESRLQLMSMDCPGQVPERLLKVVKRVLVAVNVKSVAEALQDLLFERDEEYLMDCDWRWDPVHTKGSIVRGLYYEEVRLNRLLCLDPVDYFAEPECEFGQDEMDELALEDRDHVLATILSQKQRKASIQRKLRRACLVVSLCISWRRRVGTQMERVREEAREPRAGNFKKADVDRTQCDLCGVKFTRGPENYFSPSKAFEGAASEVAVLSRAELEREECQERNSESYEQHIHLEHHQRQQVAYQKYSEFFHEKVDPAIDEGKLVVQDIEQSVWIHSHVGSKEHSHMLQKVQEHIKRVSDMVEDLYRRKAWAGAEEAMTRLVNILILSVRDARDWLMKTETRLKKEGIVQEDDYENEVEDFGELRPRRRSRKCGKQRKY"},{"id":"SEQ_07027","a":"O95359","g":"TACC2","d":"Transforming acidic coiled-coil-containing protein 2","L":2948,"m":[{"c":"EQSHEVQPG[AV]PPPPLPK","u":17,"sp":"tandem","x":"disordered_like","cf":"high","why":"Head-to-tail tandem 17-aa duplication in the N-terminal proline/polar-rich disordered region with 16 of 17 positions invariant (differing only by a conservative V/A substitution) anchoring a PPPPLPK core.","i":[[504,520,"EQSHEVQPGVPPPPLPK"],[521,537,"EQSHEVQPGAPPPPLPK"]]},{"c":"[GQ][ST]Y[NT][FL]DxD","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 8-aa motif instances in the C-terminal disordered region defined by invariant Y (pos 3) and DxD (pos 6,8) anchors flanked by conserved polar ([GQ][ST], [NT]) and hydrophobic ([FL]) positions, each also followed two residues downstream by an acidic residue.","i":[[2034,2041,"GTYNLDFD"],[2333,2340,"GTYTFDID"],[2365,2372,"QSYNFDPD"]]}],"s":"MGNENSTSDNQRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSASLDPCLVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEGCLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTLSDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRPEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEEACQRHPGASEAADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQQKMECWATSDAESPKLLASFPSAGEQGGEAGAAETGGSAGAGDPGKQQAPEKPGEATLSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDALLPARELGGIPRSTMDFSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVDSMPCLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKAGAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGEAEISHLALQDPASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGEEAVAQDRIPSGKQHQETSACDSPHGEDGPGDFAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGEVADTPLEPGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTAALHGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFASADALLSRLAHPVSLCGALDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALKLARQIALASRSHQDAKREAAHPTDVSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS"},{"id":"SEQ_07028","a":"Q5VZP5","g":"STYXL2","d":"Serine/threonine/tyrosine-interacting-like protein 2","L":1158,"m":[{"c":"[EL]x[AIL][ILY][EQA]xW[KQR]x[KRG]","u":10,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Five dispersed 10-aa amphipathic tryptophan-basic motifs embedded in the central and C-terminal disordered regions, anchored by an invariant W preceded one helical turn earlier by a hydrophobic doublet ([AIL][ILY]) and flanked by basic residues.","i":[[348,357,"EKLYEQWKKG"],[390,399,"ERIIQEWQSR"],[541,550,"LTALERWKIK"],[586,595,"LTAYQAWKLK"],[1135,1144,"EAIIAAWRRR"]]}],"s":"MATRKDTEEEQVVPSEEDEANVRAVQAHYLRSPSPSQYSMVSDAETESIFMEPIHLSSAIAAKQIINEELKPPGVRADAECPGMLESAEQLLVEDLYNRVREKMDDTSLYNTPCVLDLQRALVQDRQEAPWNEVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGVYTGPEFYTGLEIQYLGVEVDDFPEVDISQHFRKASEFLDEALLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEALMTVRKKRAIYPNEGFLKQLRELNEKLMEEREEDYGREGGSAEAEEGEGTGSMLGARVHALTVEEEDDSASHLSGSSLGKATQASKPLTLIDEEEEEKLYEQWKKGQGLLSDKVPQDGGGWRSASSGQGGEELEDEDVERIIQEWQSRNERYQAEGYRRWGREEEKEEESDAGSSVGRRRRTLSESSAWESVSSHDIWVLKQQLELNRPDHGRRRRADSMSSESTWDAWNERLLEIEKEASRRYHAKSKREEAADRSSEAGSRVREDDEDSVGSEASSFYNFCSRNKDKLTALERWKIKRIQFGFHKKDLGAGDSSGEPGAEEAVGEKNPSDVSLTAYQAWKLKHQKKVGSENKEEVVELSKGEDSALAKKRQRRLELLERSRQTLEESQSMASWEADSSTASGSIPLSAFWSADPSVSADGDTTSVLSTQSHRSHLSQAASNIAGCSTSNPTTPLPNLPVGPGDTISIASIQNWIANVVSETLAQKQNEMLLLSRSPSVASMKAVPAASCLGDDQVSMLSGHSSSSLGGCLLPQSQARPSSDMQSVLSCNTTLSSPAESCRSKVRGTSKPIFSLFADNVDLKELGRKEKEMQMELREKMSEYKMEKLASDNKRSSLFKKKKVKEDEDDGVGDGDEDTDSAIGSFRYSSRSNSQKPETDTCSSLAVCDHYASGSRVGKEMDSSINKWLSGLRTEEKPPFQSDWSGSSRGKYTRSSLLRETESKSSSYKFSKSQSEEQDTSSYHEANGNSVRSTSRFSSSSTREGREMHKFSRSTYNETSSSREESPEPYFFRRTPESSEREESPEPQRPNWARSRDWEDVEESSKSDFSEFGAKRKFTQSFMRSEEEGEKERTENREEGRFASGRRSQYRRSTDREEEEEMDDEAIIAAWRRRQEETRTKLQKRRED"},{"id":"SEQ_07041","a":"Q8NFI4","g":"ST13P5","d":"Putative protein FAM10A5","L":369,"m":[{"c":"xAxx[YK][KA]x[RA][AG]xxxxx[LD][GQ]xxxxAφx[DL]xxxAx[KE]ψ[ND][PY][DR]","u":34,"sp":"tandem","x":"structured_like","cf":"high","why":"Three head-to-tail 34-aa helical repeats with strictly conserved small alanine anchors at positions 2, 21, and 28, [AG] at position 9, conserved hydrophobic positions (22, 31), and a C-terminal [ND][PY][DR] turn motif.","i":[[113,146,"QANDKKVAAIEVLNDGELQKAIDLFTDAIKLNPR"],[147,180,"LAILYAKRASVFVKLQKPNAAIQDCDRAIEINPD"],[181,214,"SAQPYKWRGKAHRLLGHWEEAAHDLAFACKLDYD"]]},{"c":"[DN]Pxx[ML]xxφ[QS]","u":9,"sp":"dispersed","x":"structured_like","cf":"high","why":"Four C-terminal 9-aa amphipathic helical motifs anchored by an N-terminal [DN]P cap, aliphatic [ML] at position 5, bulky hydrophobic φ at position 8, and polar [QS] (predominantly Q) at position 9 separated by 0-4 aa linkers.","i":[[319,327,"DPEALAAMQ"],[328,336,"DPEVMVAFQ"],[341,349,"NPANMSKYQ"],[351,359,"NPKVMNLIS"]]}],"s":"MDPCKVNELRAFVKMCKQDPSVLHTEEMRFLREWVESMGGKVPPATQKAKSEENTKEEKPDSKKVEEDLKADEPSTEESDLEIDKEGVIEPDTDAPQEMGDENVEITEEMMDQANDKKVAAIEVLNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIQDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLAFACKLDYDEDASAMLKEVQPRAQKIAEHWRKYERKHEEREIKERIERVKKAQEEQERAQREEEARRQSGAHYGPFPGGFPGGMPGNFPGGMPGMGGDMPGMAGMPGLNEILSDPEALAAMQDPEVMVAFQDVAQNPANMSKYQSNPKVMNLISKLSAKFGGQA"},{"id":"SEQ_07053","a":"Q9UNF1","g":"MAGED2","d":"Melanoma-associated antigen D2","L":606,"m":[{"c":"[AG]RR[AVG][SLK]xx[LPR]x[AS]x[WMK]","u":12,"sp":"tandem","x":"mixed","cf":"high","why":"Five contiguous 12-aa head-to-tail repeats spanning 60 residues, anchored by an invariant RR dyad after [AG] at positions 1-3, small [AVG] at position 4, [AS] at position 10, and [WMK] at position 12.","i":[[202,213,"GRRVSKALMASM"],[214,225,"ARRASRGPIAFW"],[226,237,"ARRASRTRLAAW"],[238,249,"ARRALLSLRSPK"],[250,261,"ARRGKARRRAAK"]]},{"c":"[VA]S[KE][ADT]x[EGK]","u":6,"sp":"tandem","x":"disordered_like","cf":"high","why":"Five head-to-tail 6-aa repeats in the N-terminal disordered region anchored by a conserved [VA]S[KE] core (predominantly VSK) followed by small/polar [ADT] at position 4 and [EGK] at position 6.","i":[[45,50,"ASKALE"],[51,56,"VSEDVK"],[57,62,"VSKASG"],[63,68,"VSKATE"],[69,74,"VSKTPE"]]}],"s":"MSDTSESGAGLTRFQAEASEKDSSSMMQTLLTVTQNVEVPETPKASKALEVSEDVKVSKASGVSKATEVSKTPEAREAPATQASSTTQLTDTQVLAAENKSLAADTKKQNADPQAVTMPATETKKVSHVADTKVNTKAQETEAAPSQAPADEPEPESAAAQSQENQDTRPKVKAKKARKVKHLDGEEDGSSDQSQASGTTGGRRVSKALMASMARRASRGPIAFWARRASRTRLAAWARRALLSLRSPKARRGKARRRAAKLQSSQEPEAPPPRDVALLQGRANDLVKYLLAKDQTKIPIKRSDMLKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYILLSTLEPTDAGILGTTKDSPKLGLLMVLLSIIFMNGNRSSEAVIWEVLRKLGLRPGIHHSLFGDVKKLITDEFVKQKYLDYARVPNSNPPEYEFFWGLRSYYETSKMKVLKFACKVQKKDPKEWAAQYREAMEADLKAAAEAAAEAKARAEIRARMGIGLGSENAAGPCNWDEADIGPWAKARIQAGAEAKAKAQESGSASTGASTSTNNSASASASTSGGFSAGASLTATLTFGLFAGLGGAGASTSGSSGACGFSYK"},{"id":"SEQ_07072","a":"Q9P2Y4","g":"ZNF219","d":"Zinc finger protein 219","L":722,"m":[{"c":"xxCxxCxxxxxxxxxxxxH(x){3,4}H","u":"23-24","sp":"dispersed","x":"structured_like","cf":"high","why":"Nine C2H2-type repeats anchored by invariant CxxC and H(x){3,4}H coordinating pairs separated by a strict 12-residue core, typically preceded by an aromatic/His residue and containing conserved aliphatics (L/M in 8/9 copies) before and after the first His; arranged as four closely spaced pairs plus one C-terminal singleton separated by long proline-rich linkers.","i":[[57,79,"FPCPVCGKRFRFNSILALHLRAH"],[85,107,"FQCPHCGHRAAQRALLRSHLRTH"],[163,186,"FRCPYCKGKFRTSAERERHLHILH"],[189,212,"WKCGLCSFGSSQEEELLHHSLTAH"],[274,296,"FRCQVCGQSFTQSWFLKGHMRKH"],[302,324,"HACPVCGRCFKEPWFLKNHMKVH"],[498,520,"KDCPFCGKSFRSAHHLKVHLRVH"],[526,548,"YKCPHCDYAGTQSGSLKYHLQRH"],[646,668,"HRCLFCPFATGAPELMALHLQVH"]]}],"s":"MEGSRPRAPSGHLAPSPPAFDGELDLQRYSNGPAVSAGSLGMGAVSWSESRAGERRFPCPVCGKRFRFNSILALHLRAHPGAQAFQCPHCGHRAAQRALLRSHLRTHQPERPRSPAARLLLELEERALLREARLGRARSSGGMQATPATEGLARPQAPSSSAFRCPYCKGKFRTSAERERHLHILHRPWKCGLCSFGSSQEEELLHHSLTAHGAPERPLAATSAAPPPQPQPQPPPQPEPRSVPQPEPEPEPEREATPTPAPAAPEEPPAPPEFRCQVCGQSFTQSWFLKGHMRKHKASFDHACPVCGRCFKEPWFLKNHMKVHASKLGPLRAPGPASGPARAPQPPDLGLLAYEPLGPALLLAPAPTPAERREPPSLLGYLSLRAGEGRPNGEGAEPGPGRSFGGFRPLSSALPARARRHRAEEPEEEEEVVEAEEETWARGRSLGSLASLHPRPGEGPGHSASAAGAQARSTATQEENGLLVGGTRPEGGRGATGKDCPFCGKSFRSAHHLKVHLRVHTGERPYKCPHCDYAGTQSGSLKYHLQRHHREQRSGAGPGPPPEPPPPSQRGSAPQSGAKPSPQPATWVEGASSPRPPSSGAGPGSRRKPASPGRTLRNGRGGEAEPLDLSLRAGPGGEAGPGGALHRCLFCPFATGAPELMALHLQVHHSRRARGRRPPQADASPPYARVPSGETPPSPSQEGEEGSGLSRPGEAGLGGQER"},{"id":"SEQ_07078","a":"Q6UXX5","g":"ITIH6","d":"Inter-alpha-trypsin inhibitor heavy chain H6","L":1313,"m":[{"c":"xxxxxxx[KRG]Pxx[PLS]xxxx","u":16,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Eleven 16-residue repeats in the central Pro/Ser-rich disordered region (residues 717-966), including a two-copy tandem pair and a six-copy head-to-tail tandem block (residues 802-897) flanked by dispersed copies. Copies share an invariant central P preceded by a basic residue (K/R in 10/11 copies, G in one tandem copy), frequent upstream L/P positions, G-enrichment at +1, hydrophobic residues at +2, and a constrained [PLS] position at +3.","i":[[717,732,"AQPTLRTKPTILVPSN"],[733,748,"SGTLLPLKPGSLSHQN"],[757,772,"RTQVPPVKPGIPASPK"],[778,793,"CVTPLHSKPGAPSHPQ"],[802,817,"PKGLPQSRPGVSTLQV"],[818,833,"PKYPLHTRPRVPAPKT"],[834,849,"RNNMPHLGPGILLSKT"],[850,865,"PKILLSLKPSAPPHQI"],[866,881,"STSISLSKPETPNPHM"],[882,897,"PQTPLPPRPDRPRPPL"],[954,969,"RQVLGPSRPGVPTMSL"]]}],"s":"MSGWRYLICVSFLLTILLELTYQGPPVPASSSTKLLMTSYSMRSTVVSRYAHTLVTSVLFNPHAEAHEAIFDLDLPHLAFISNFTMTINNKVYIAEVKEKHQAKKIYEEAHQQGKTAAHVGIRDRESEKFRISTSLAAGTEVTFSLAYEELLQRHQGQYQLVVSLRPGQLVKRLSIEVTVSERTGISYVHIPPLRTGRLRTNAHASEVDSPPSTRIERGETCVRITYCPTLQDQSSISGSGIMADFLVQYDVVMEDIIGDVQIYDDYFIHYFAPRGLPPMEKNVVFVIDVSSSMFGTKMEQTKTAMNVILSDLQANDYFNIISFSDTVNVWKAGGSIQATIQNVHSAKDYLHCMEADGWTDVNSALLAAASVLNHSNQEPGRGPSVGRIPLIIFLTDGEPTAGVTTPSVILSNVRQALGHRVSLFSLAFGDDADFTLLRRLSLENRGIARRIYEDTDAALQLKGLYEEISMPLLADVRLNYLGGLVGASPWAVFPNYFGGSELVVAGQVQPGKQELGIHLAARGPKDQLLVAHHSEGATNNSQKAFGCPGEPAPNVAHFIRRLWAYVTIGELLDAHFQARDTTTRHLLAAKVLNLSLEYNFVTPLTSLVMVQPKQASEETRRQTSTSAGPDTIMPSSSSRHGLGVSTAQPALVPKVISPKSRPVKPKFYLSSTTTASTKKMLSSKELEPLGESPHTLSMPTYPKAKIPAQQDSGTLAQPTLRTKPTILVPSNSGTLLPLKPGSLSHQNPDILPTNSRTQVPPVKPGIPASPKADTVKCVTPLHSKPGAPSHPQLGALTSQAPKGLPQSRPGVSTLQVPKYPLHTRPRVPAPKTRNNMPHLGPGILLSKTPKILLSLKPSAPPHQISTSISLSKPETPNPHMPQTPLPPRPDRPRPPLPESLSTFPNTISSSTGPSSTTTTSVLGEPLPMPFTPTLPPGRFWHQYDLLPGPQRTRQVLGPSRPGVPTMSLLNSSRPTPEGSPPNLPILLPSSILPEAISLLLLPEELELLSESMVESKFVESLNPPAFYTFLTPDEDGSPNWDGNSEEILGGAGGSMESQGSSVGLAKGTLPSIFTFSSSVDGDPHFVIQIPHSEEKICFTLNGHPGDLLQLIEDPKAGLHVSGKLLGAPPRPGHKDQTRTYFQIITVTTDKPRAYTITISRSSISLRGEGTLRLSWDQPALLKRPQLELYVAAAARLTLRLGPYLEFLVLRHRYRHPSTLQLPHLGFYVANGSGLSPSARGLIGQFQHADIRLVTGPMGPCLRRHHGPDVPVILGKRLLKDSPRLLPRWASCWLVKRSHVELLLGHPYLSYVL"},{"id":"SEQ_07085","a":"Q9HCD6","g":"TANC2","d":"Protein TANC2","L":1990,"m":[{"c":"Gxx[PA]ψ(x){0,1}xxAxxxGxxxψVxφLψxxGAxψxxxxxx","u":"33-34","sp":"tandem","x":"structured_like","cf":"high","why":"Ten tandem 33-34 aa structural repeats (eight strictly head-to-tail pairs and two short 7-10 aa internal linkers) defined by conserved Gxx[PA]ψ N-terminal turns, central GxxxψVxφLψ hydrophobic cores with invariant Leu20, and GAxψ motifs.","i":[[884,917,"NNAPILCVQSHLGYTEMVALLLEFGANVDASSES"],[918,950,"GLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKN"],[951,983,"GQCALVHAALRGHLEVVKFLIQCDWTMAGQQQG"],[991,1023,"IQQALIAAASMGYTEIVSYLLDLPEKDEEEVER"],[1034,1066,"GETALTAAAGRGKLEVCRLLLEQGAAVAQPNRR"],[1067,1099,"GAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQ"],[1100,1132,"GRTPLMMAASEGHLGTVDFLLAQGASIALMDKE"],[1133,1165,"GLTALSWACLKGHLSVVRSLVDNGAATDHADKN"],[1166,1198,"GRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYS"],[1199,1231,"GMRPLDRAVGCRNTSVVVTLLKKGAKIGPATWA"]]},{"c":"[GN]x[HSQ]YRxSPP","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three closely clustered 9-aa copies in the C-terminal P/S/Q-rich disordered tail anchored by an invariant YRxSPP core (fixed Tyr, Arg, Ser, and Pro-Pro) and conserved [GN]x[HSQ] N-terminal flanking positions, with an intervening 1-aa-shorter GKEYPSPP variant.","i":[[1495,1503,"NSHYRPSPP"],[1511,1519,"GGSYRFSPP"],[1539,1547,"GPQYRASPP"]]},{"c":"SP[CT]STL","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three clustered hexapeptide repeats within a 46-aa segment of the N-terminal disordered region sharing five invariant positions (S, P, S, T, and C-terminal Leu anchor), including two identical Cys-containing SPCSTL copies.","i":[[129,134,"SPCSTL"],[145,150,"SPCSTL"],[169,174,"SPTSTL"]]}],"s":"MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGDAEQELGPPPSVDEAANTLMTRLGFLLGEKVTEVQPGDQYSMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPISTNATAKDCSYGAVTSPTSTLESRDSGIIATLTSYSENVERTKYAGESSKELGSGGNIKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVAATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVRFAPYRPPDISLKPLLFEVPSITTESVFVGRDWVFHEIDAQLQSSNASVNQGVVIVGNIGFGKTAIISRLVALSCHGTRMRQIASDSPHASPKHVDANRELPLTQPPSAHSSITSGSCPGTPEMRRRQEEAMRRLASQVVAYHYCQADNAYTCLVPEFVHNVAALLCRSPQLTAYREQLLREPHLQSMLSLRSCVQDPMASFRRGVLEPLENLHKERKIPDEDFIILIDGLNEAEFHKPDYGDTIVSFLSKMIGKFPSWLKLIVTVRTSLQEITKLLPFHRIFLDRLEENEAIDQDLQAYILHRIHSSSEIQNNISLNGKMDNTTFGKLSSHLKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYKVVPVSLSEVYLLQCNMKFPTQSSFDRVMPLLNVAVASLHPLTDEHIFQAINAGSIEGTLEWEDFQQRMENLSMFLIKRRDMTRMFVHPSFREWLIWREEGEKTKFLCDPRSGHTLLAFWFSRQEGKLNRQQTIELGHHILKAHIFKGLSKKVGVSSSILQGLWISYSTEGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMFYKKGKVKEAAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEECRQMQQPQQPPPPPQPQQQLPEEAEPEPQHEDIYSVQDIFEEEYLEQDVENVSIGLQTEARPSQGLPVIQSPPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTYQSTSPALSPTHQNSHYRPSPPHTSPAHQGGSYRFSPPPVGGQGKEYPSPPPSPLRRGPQYRASPPAESMSVYRSQSGSPVRYQQETSVSQLPGRPKSPLSKMAQRPYQMPQLPVAVPQQGLRLQPAKAQIVRSNQPSPAVHSSTVIPTGAYGQVAHSMASKYQSSQGDIGVSQSRLVYQGSIGGIVGDGRPVQHVQASLSAGAICQHGGLTKEDLPQRPSSAYRGGVRYSQTPQIGRSQSASYYPVCHSKLDLERSSSQLGSPDVSHLIRRPISVNPNEIKPHPPTPRPLLHSQSVGLRFSPSSNSISSTSNLTPTFRPSSSIQQMEIPLKPAYERSCDELSPVSPTQGGYPSEPTRSRTTPFMGIIDKTARTQQYPHLHQQNRTWAVSSVDTVLSPTSPGNLPQPESFSPPSSISNIAFYNKTNNAQNGHLLEDDYYSPHGMLANGSRGDLLERVSQASSYPDVKVARTLPVAQAYQDNLYRQLSRDSRQGQTSPIKPKRPFVESNV"},{"id":"SEQ_07088","a":"Q6DN12","g":"MCTP2","d":"Multiple C2 and transmembrane domain-containing protein 2","L":878,"m":[{"c":"ψψoψxψxx[GA]x[ND]ψ(x){6,9}-[PM]ΩxxφxL[GN][GDN](x){6,7}[TV]ψ[YC]K[NS]φNPxWx[EK]xφxφ[PH]φxxxxxxψxxxxφ[DW](x){6,8}-[FR]ψGxxxψxψ(x){19,25}G[VA]ψφψxψxL","u":"111-119","sp":"periodic","x":"structured_like","cf":"high","why":"Three ~111-119 aa globular domain repeats separated by regular ~42-44 aa linkers, anchored by conserved -[PM]ΩxxφxL, K[NS]φNPxW, -[FR]ψG, and C-terminal G[VA]ψφψxψxL beta-strand/turn motifs across all three copies.","i":[[195,313,"LLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLPIQSLDQKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDMGVIVLNLNL"],[357,467,"IISITLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTL"],[510,626,"ILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDL"]]}],"s":"MDLDKPSVWGSLKQRTRPLLINLSKKKVKKNPSKPPDLRARHHLDRRLSLSVPDLLEAEALAPEGRPYSGPQSSYTSVPSSLSTAGIFPKSSSSSLKQSEEELDWSQEEASHLHVVETDSEEAYASPAERRRVSSNGIFDLQKTSLGGDAPEEPEKLCGSSDLNASMTSQHFEEQSVPGEASDGLSNLPSPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLPIQSLDQKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFAVFLITVWNFELYMIPLALLLIFVYNFIRPVKGKVSSIQDSQESTDIDDEEDEDDKESEKKGLIERIYMVQDIVSTVQNVLEEIASFGERIKNTFNWTVPFLSSLACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDNNELLDFLSRVPSDVQKVQYAELKLCSSHSPLRKKRSAL"},{"id":"SEQ_07098","a":"Q9NQV8","g":"PRDM8","d":"PR domain zinc finger protein 8","L":689,"m":[{"c":"CxxC[NS]x[RS]F[QR]xxxx[LY][SV]xH[LM][RT](x){1,2}[CH]","u":"21-22","sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed zinc-finger-like repeats (one N-proximal and two near the C-terminus) anchored by invariant CxxC, F, and H positions plus a conserved [LY] hydrophobic core and C-terminal [CH] ligand separated by a 3-4 residue linker.","i":[[157,178,"CLECSQRFQFEFPYVAHLRFRC"],[627,647,"CAKCNASFRMTSDLVYHMRSH"],[668,688,"CPICNESFRERHHLSRHMTSH"]]},{"c":"+[GKR]SAF[STV]","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed hexapeptide motifs within the central Pro/Gly/Ser/Ala-rich disordered region sharing an invariant SAF core flanked by an N-terminal basic (+[GKR]) dipeptide and a C-terminal [STV] residue.","i":[[382,387,"KRSAFV"],[456,461,"RGSAFT"],[497,502,"RKSAFS"]]}],"s":"MEDTGIQRGIWDGDAKAVQQCLTDIFTSVYTTCDIPENAIFGPCVLSHTSLYDSIAFIALKSTDKRTVPYIFRVDTSAANGSSEGLMWLRLVQSARDKEEQNLEAYIKNGQLFYRSLRRIAKDEELLVWYGKELTELLLLCPSRSHNKMNGSSPYTCLECSQRFQFEFPYVAHLRFRCPKRLHSADISPQDEQGGGVGTKDHGGGGGGGKDQQQQQQEAPLGPGPKFCKAGPLHHYPSPSPESSNPSAAAGGSSAKPSTDFHNLARELENSRGGSSCSPAQSLSSGSGSGGGGGHQEAELSPDGIATGGGKGKRKFPEEAAEGGGGAGLVGGRGRFVERPLPASKEDLVCTPQQYRASGSYFGLEENGRLFAPPSPETGEAKRSAFVEVKKAARAASLQEEGTADGAGVASEDQDAGGGGGSSTPAAASPVGAEKLLAPRPGGPLPSRLEGGSPARGSAFTSVPQLGSAGSTSGGGGTGAGAAGGAGGGQGAASDERKSAFSQPARSFSQLSPLVLGQKLGALEPCHPADGVGPTRLYPAAADPLAVKLQGAADLNGGCGSLPSGGGGLPKQSPFLYATAFWPKSSAAAAAAAAAAAAGPLQLQLPSALTLLPPSFTSLCLPAQNWCAKCNASFRMTSDLVYHMRSHHKKEYAMEPLVKRRREEKLKCPICNESFRERHHLSRHMTSHN"},{"id":"SEQ_07125","a":"Q01954","g":"BNC1","d":"Zinc finger protein basonuclin-1","L":994,"m":[{"c":"CxφC[EKQ]KT[FY]x[DN][AK][CG][ST]φ+φH[HY][KN]x[MV]H[LV]+xxH[KT]C[KT][IV][EP]GCNxxF[PS]SxRSR[DN]RHSxN[LP]N(x){0,2}LH","u":"54-56","sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed 54-56 aa tandem double-C2H2 zinc-finger modules sharing invariant C/H coordination residues and ultra-conserved recognition motifs (KT[FY], GCNxxF[PS]SxRSR[DN]RHSxN[LP]N(x){0,2}LH), with a 2-residue loop insertion before the final LH in the first copy.","i":[[359,414,"CTACEKTFYDKGTLKIHYNAVHLKIKHKCTIEGCNMVFSSLRSRNRHSANPNPRLH"],[722,775,"CDICKKTFKNACSVKIHHKNMHVKEMHTCTVEGCNATFPSRRSRDRHSSNLNLH"],[930,983,"CHLCQKTYSNKGTFRAHYKTVHLRQLHKCKVPGCNTMFSSVRSRNRHSQNPNLH"]]}],"s":"MRRRPPSRGGRGAARARETRRQPRHRSGRRMAEAISCTLNCSCQSFKPGKINHRQCDQCKHGWVAHALSKLRIPPMYPTSQVEIVQSNVVFDISSLMLYGTQAIPVRLKILLDRLFSVLKQDEVLQILHALDWTLQDYIRGYVLQDASGKVLDHWSIMTSEEEVATLQQFLRFGETKSIVELMAIQEKEEQSIIIPPSTANVDIRAFIESCSHRSSSLPTPVDKGNPSSIHPFENLISNMTFMLPFQFFNPLPPALIGSLPEQYMLEQGHDQSQDPKQEVHGPFPDSSFLTSSSTPFQVEKDQCLNCPDAITKKEDSTHLSDSSSYNIVTKFERTQLSPEAKVKPERNSLGTKKGRVFCTACEKTFYDKGTLKIHYNAVHLKIKHKCTIEGCNMVFSSLRSRNRHSANPNPRLHMPMNRNNRDKDLRNSLNLASSENYKCPGFTVTSPDCRPPPSYPGSGEDSKGQPAFPNIGQNGVLFPNLKTVQPVLPFYRSPATPAEVANTPGILPSLPLLSSSIPEQLISNEMPFDALPKKKSRKSSMPIKIEKEAVEIANEKRHNLSSDEDMPLQVVSEDEQEACSPQSHRVSEEQHVQSGGLGKPFPEGERPCHRESVIESSGAISQTPEQATHNSERETEQTPALIMVPREVEDGGHEHYFTPGMEPQVPFSDYMELQQRLLAGGLFSALSNRGMAFPCLEDSKELEHVGQHALARQIEENRFQCDICKKTFKNACSVKIHHKNMHVKEMHTCTVEGCNATFPSRRSRDRHSSNLNLHQKALSQEALESSEDHFRAAYLLKDVAKEAYQDVAFTQQASQTSVIFKGTSRMGSLVYPITQVHSASLESYNSGPLSEGTILDLSTTSSMKSESSSHSSWDSDGVSEEGTVLMEDSDGNCEGSSLVPGEDEYPICVLMEKADQSLASLPSGLPITCHLCQKTYSNKGTFRAHYKTVHLRQLHKCKVPGCNTMFSSVRSRNRHSQNPNLHKSLASSPSHLQ"},{"id":"SEQ_07133","a":"O95835","g":"LATS1","d":"Serine/threonine-protein kinase LATS1","L":1130,"m":[{"c":"+[PS]x-AA(x){3,5}ψSKMS[TY][EQ]DPR[QR]x[QR]","u":"22-24","sp":"dispersed","x":"mixed","cf":"high","why":"Two strongly conserved 22-24 aa N-terminal modules anchored by a basic residue (+), an acidic-dialanine (-AA) helix segment, a 3-5 residue linker, and a signature ψSKMS[TY][EQ]DPR[QR]x[QR] cap motif.","i":[[43,66,"KPSDAAKAEHNMSKMSTEDPRQVR"],[129,150,"RSIEAAIEFISKMSYQDPRREQ"]]},{"c":"[KQ][AM]LQ-[IL][QR]","u":7,"sp":"dispersed","x":"structured_like","cf":"medium","why":"Three non-overlapping 7 aa amphipathic helical repeats in the N-terminal domain anchored by invariant LQ, flanked by [KQ][AM] N-terminally and acidic-aliphatic-polar (-[IL][QR]) positions C-terminally.","i":[[29,35,"QMLQEIR"],[76,82,"KALQEIR"],[104,110,"QMLQDLQ"]]}],"s":"MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSKPSDAAKAEHNMSKMSTEDPRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVNPQMLQDLQAAGFDEDMVIQALQKTNNRSIEAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQQSVNRKQSWKGSKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGYPPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQNVVPAGTVNRQPPPPYPLTAANGQSPSALQTGGSAAPSSYTNGSIPQSMMVPNRNSHNMELYNISVPGLQTNWPQSSSAPAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPFPEGTASNVTVMPPVAEAPNYQGPPPPYPKHLLHQNPSVPPYESISKPSKEDQPSLPKEDESEKSYENVDSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTFRRFFDDNGYPYNYPKPIEYEYINSQGSEQQSDEDDQNTGSEIKNRDLVYV"},{"id":"SEQ_07143","a":"Q13428","g":"TCOF1","d":"Treacle protein","L":1488,"m":[{"c":"[QE]xKxxx[KN]xxQx[KRG][AP]x[SPL]xxxxx[STP]xx[GKA]xx[PVS][AVT]x(x){9,57}-[DEN]SxSS[SE]E[EGS][SD][DSE][SDE](x){6,13}","u":"63-106","sp":"tandem","x":"disordered_like","cf":"high","why":"Ten contiguous head-to-tail disordered repeats (63-106 aa, residues 213-952) sharing a bipartite basic-to-acidic architecture: a conserved 19-residue N-terminal segment anchored by invariant K3 and Q10 ([QE]xKxxx[KN]xxQx[KRG][AP]x[SPL]xxxx), a variable Pro/Ala/Gly/Lys-rich middle segment (canonically ~28 aa, expanded in copy 9 via partial internal duplication), and a strongly conserved acidic serine-rich C-terminal block (-[DEN]SxSS[SE]E[EGS][SD][DSE][SDE] followed by an EAPA-like cap).","i":[[213,289,"EGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRS"],[290,360,"QVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL"],[361,425,"QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPA"],[426,495,"QAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAA"],[496,567,"QVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPA"],[568,630,"QEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAA"],[631,713,"QAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVG"],[714,779,"QAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPA"],[780,885,"QVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLA"],[886,952,"QVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSA"]]}],"s":"MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQTV"},{"id":"SEQ_07169","a":"Q15878","g":"CACNA1E","d":"Voltage-dependent R-type calcium channel subunit alpha-1E","L":2313,"m":[{"c":"F[EY]φxψψ[ASL]xψ[AI][AL][NS][CST]φ[ACV]ψ[AM]φ(x){17,20}xφF[ILT][GM]ψFx[FL]E[AMC][GSV][IL]Kψφ[AGD]xG[FLP][ILR](x){10,14}DF[GIV][VT][VT]ψ[GS][GAS][IL]x[AE]x(x){14,20}+φφRφφR[PIL]φK[ILT]xxxx[APY]x[IL][KQR][AIN][LV]φx[CST]φ[MV]x[AS]φ[KV]xψxxψ[GLC]φ[LV]φ[AFK]φφφφψ[FY]Aψ[IL][GA]ψ[EQ]φ[FY][GSK][GN](x){19,53}ψ[LM][LT][LV]F[QTR]xxT[GM]E[GAD]Wx[EQT][IV][LM][YQL][NHS](x){11,29}ψ[FY][FY][IV][PVS]φ[FIT]φ[FIV][GFC][NPS][FY][FLT]φ[LV]Nψ[FV][LV][GA]ψφx[GDI][ENT][FL][AQE]x","u":"231-274","sp":"dispersed","x":"structured_like","cf":"high","why":"Four large dispersed homologous structured-like repeats (231-274 aa) sharing six conserved hydrophobic segments separated by variable-length loops, anchored by invariant F/E/K/G, DF, periodic basic (+φφRφφR[PIL]φK), FxxxT[GM]E[GAD]W, and Nψ[FV] motifs.","i":[[91,356,"FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAK"],[478,708,"FYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLAN"],[1155,1428,"FEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQE"],[1480,1728,"FEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEY"]]},{"c":"-RRRRHHMS[MV]WE[PQ]R[ST]S[HQ]LR","u":19,"sp":"tandem","x":"disordered_like","cf":"high","why":"Head-to-tail 19-aa tandem duplication in the central polar/charged linker between the second and third large structured repeats, sharing 14/19 identical residues (RRRRHHMS, WE, R, S, LR) and conservative substitutions at four positions.","i":[[749,767,"DRRRRHHMSMWEPRSSHLR"],[768,786,"ERRRRHHMSVWEQRTSQLR"]]}],"s":"MARFGEAVVARPGSGDGDSDQSRNRQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRERRRRHHMSVWEQRTSQLRKHMQMSSQEALNREEAPTMNPLNPLNPLSSLNPLNAHPSLYRRPRAIEGLALGLALEKFEEERISRGGSLKGDGGDRSSALDNQRTPLSLGQREPPWLARPCHGNCDPTQQEAGGGEAVVTFEDRARHRQSQRRSRHRRVRTEGKESSSASRSRSASQERSLDEAMPTEGEKDHELRGNHGAKEPTIQEERAQDLRRTNSLMVSRGSGLAGGLDEADTPLVLPHPELEVGKHVVLTEQEPEGSSEQALLGNVQLDMGRVISQSEPDLSCITANTDKATTESTSVTVAIPDVDPLVDSTVVHISNKTDGEASPLKEAEIREDEEEVEKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQKNAPMFQRMEPSSLPQEIIANAKALPYLQQDPVSGLSGRSGYPSMSPLSPQDIFQLACMDPADDGQFQERQSLEPEVSELKSVQPSNHGIYLPSDTQEHAGSGRASSMPRLTVDPQVVTDPSSMRRSFSTIRDKRSNSSWLEEFSMERSSENTYKSRRRSYHSSLRLSAHRLNSDSGHKSDTHRSGGRERGRSKERKHLLSPDVSRCNSEERGTQADWESPERRQSRSPSEGRSQTPNRQGTGSLSESSIPSVSDTSTPRRSRRQLPPVPPKPRPLLSYSSLIRHAGSISPPADGSEEGSPLTSQALESNNACLTESSNSPHPQQSQHASPQRYISEPYLALHEDSHASDCGEEETLTFEAAVATSLGRSNTIGSAPPLRHSWQMPNGHYRRRRRGGPGPGMMCGAVNNLLSDTEEDDKC"},{"id":"SEQ_07171","a":"Q8IZU1","g":"FAM9A","d":"Protein FAM9A","L":332,"m":[{"c":"MEPVGRKRSRKAAKAQLEAQV[TR]AA","u":24,"sp":"dispersed","x":"mixed","cf":"high","why":"Near-exact 24-residue N-terminal duplication (23/24 identical positions, differing only at position 22 T/R) combining a basic disordered segment with an alanine-rich amphipathic segment, separated by a 19-aa polar linker.","i":[[1,24,"MEPVGRKRSRKAAKAQLEAQVTAA"],[44,67,"MEPVGRKRSRKAAKAQLEAQVRAA"]]}],"s":"MEPVGRKRSRKAAKAQLEAQVTAAQGATKEGSGIASNFPGQPTMEPVGRKRSRKAAKAQLEAQVRAAPAKKHTGKDPVRDECEERNPFTETREEDVTDEHGEREPFAEKDEHTGIHTMKLEHIAADIKKGLAAKREMIKIDKAAYRKTKNTIERALKKKQLKRQKRDYRHTRKLLNVLKEYIAEKQKDDEAEEAEAAAAAAEAAAAAEAAAAAAEVIVVEDEEEEEKEEEEEKEEEEEEGEEEGGGEEGEEGGGGGEGEETEEEEEEEEEEEEEEQIKAFQEKQKRWQQPTGVRSWRLREMKPLLEQLLKAAKDTKDNYCIISSSEESELDN"},{"id":"SEQ_07173","a":"A0A0J9YXQ4","g":"PNMA6E","d":"Paraneoplastic antigen Ma6E","L":647,"m":[{"c":"[AVT]GE[AGV]G[AG]","u":6,"sp":"tandem","x":"disordered_like","cf":"high","why":"Gapless head-to-tail array of 29 hexapeptide units (residues 121-294) anchored by strictly invariant G2 and E3 (29/29) and near-invariant G5 (28/29, one R substitution in AGEGRA), with constrained small/aliphatic choices at positions 1, 4, and 6 and zero prolines.","i":[[121,126,"AGEGGG"],[127,132,"AGEAGG"],[133,138,"VGEVGA"],[139,144,"AGEAGG"],[145,150,"TGEAGA"],[151,156,"TGEAGA"],[157,162,"AGEAGG"],[163,168,"AGEAGG"],[169,174,"VGEAGA"],[175,180,"AGEAGG"],[181,186,"AGEAGA"],[187,192,"AGEGGA"],[193,198,"AGEAGG"],[199,204,"AGEAGG"],[205,210,"VGEAGA"],[211,216,"AGEAGG"],[217,222,"AGEAGG"],[223,228,"VGEAGA"],[229,234,"AGEAGG"],[235,240,"AGEAGA"],[241,246,"AGEAGG"],[247,252,"AGEGRA"],[253,258,"AGEAGA"],[259,264,"AGEAGA"],[265,270,"VGEAGA"],[271,276,"AGEAGA"],[277,282,"VGEAGA"],[283,288,"AGEAGA"],[289,294,"VGEAGG"]]}],"s":"MALAMLRDWCRWMGANAERSLLILGIPDDCKEHEFQEAVRAALSPLGRYRVLTKHFRKELGAKAALVEFAEYLNRSLIPHQIPGNGGPWKVIFLPQVPVIEFQDMPSFPAQPQGQAVAKAAGEGGGAGEAGGVGEVGAAGEAGGTGEAGATGEAGAAGEAGGAGEAGGVGEAGAAGEAGGAGEAGAAGEGGAAGEAGGAGEAGGVGEAGAAGEAGGAGEAGGVGEAGAAGEAGGAGEAGAAGEAGGAGEGRAAGEAGAAGEAGAVGEAGAAGEAGAVGEAGAAGEAGAVGEAGGTNVTKAWVQPWRCTLQPVLENRAYRELRPFSRREQPGCEEESFESWVEHAKDMLQLWCHASEREKKRWLLESLGGPALEVVSGLLEEDTNLSALDCLAALGQVFRNQDTRMTSRLKFLTCTQGPQEGLFAFVVRLEGLLQRAVEKGAVCPALANYLRLQQVLSWARPSEALQDTLRGMQLEKRPPGFLGLLRLIREMEAWAAFPARSQQGVAWAAAPVESEDPAAAQASPAQGNASEAGPGAEDAAEAASATKEAARGAPAAGEGESAPAGPEGLGQARPIEVPWGSSPARMSSAVWVFPRGLSWGPEGLIQVRGQEARKPPLEGLQTILEEPENEDEDGAGDEGQPKSSQGK"},{"id":"SEQ_07186","a":"Q12872","g":"SFSWAP","d":"Splicing factor, suppressor of white-apricot homolog","L":951,"m":[{"c":"ψI-+xAxΩVxRoGφ[QK]FExxψ+AK(x){4,6}F-FLxxxHxφNxYYxFx[QK][KQ]","u":"46-48","sp":"dispersed","x":"structured_like","cf":"high","why":"Two-copy internal domain duplication (residues 212-259 and 459-504) separated by a ~200-aa proline/threonine-rich linker, sharing 17 identical anchor positions (I, A, V, R, G, F, E, A, K, F, F, L, H, N, Y, Y, F) and conserved hydrophobic/charged positions across two ungapped blocks flanking a 4-6 aa loop.","i":[[211,258,"IIERTASFVCRQGAQFEIMLKAKQARNSQFDFLRFDHYLNPYYKFIQK"],[459,504,"VIDKLAEYVARNGLKFETSVRAKNDQRFEFLQPWHQYNAYYEFKKQ"]]}],"s":"MYGASGGRAKPERKSGAKEEAGPGGAGGGGSRVELLVFGYACKLFRDDERALAQEQGQHLIPWMGDHKILIDRYDGRGHLHDLSEYDAEYSTWNRDYQLSEEEARIEALCDEERYLALHTDLLEEEARQEEEYKRLSEALAEDGSYNAVGFTYGSDYYDPSEPTEEEEPSKQREKNEAENLEENEEPFVAPLGLSVPSDVELPPTAKMHAIIERTASFVCRQGAQFEIMLKAKQARNSQFDFLRFDHYLNPYYKFIQKAMKEGRYTVLAENKSDEKKKSGVSSDNEDDDDEEDGNYLHPSLFASKKCNRLEELMKPLKVVDPDHPLAALVRKAQADSSTPTPHNADGAPVQPSQVEYTADSTVAAMYYSYYMLPDGTYCLAPPPPGIDVTTYYSTLPAGVTVSNSPGVTTTAPPPPGTTPLPPPTTAETSSGATSTTTTTSALAPVAAIIPPPPDVQPVIDKLAEYVARNGLKFETSVRAKNDQRFEFLQPWHQYNAYYEFKKQFFLQKEGGDSMQAVSAPEEAPTDSAPEKPSDAGEDGAPEDAAEVGARAGSGGKKEASSSKTVPDGKLVKASFAPISFAIKAKENDLLPLEKNRVKLDDDSDDDEESKEGQESSSSAANTNPAVAPPCVVVEEKKPQLTQEELEAKQAKQKLEDRLAAAAREKLAQASKESKEKQLQAERKRKAALFLQTLKNPLPEAEAGKIEESPFSVEESSTTPCPLLTGGRPLPTLEVKPPDRPSSKSKDPPREEEKEKKKKKHKKRSRTRSRSPKYHSSSKSRSRSHSKAKHSLPSAYRTVRRSRSRSRSPRRRAHSPERRREERSVPTAYRVSRSPGASRKRTRSRSPHEKKKKRRSRSRTKSKARSQSVSPSKQAAPRPAAPAAHSAHSASVSPVESRGSSQERSRGVSQEKEAQISSAIVSSVQSKITQDLMAKVRAMLAASKNLQTSAS"},{"id":"SEQ_07188","a":"P47974","g":"ZFP36L2","d":"mRNA decay activator protein ZFP36L2","L":494,"m":[{"c":"+YKTELCRxFxxxGxCxYGx+CxFφHxφxE","u":30,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 30-residue C-x8-C-x5-C-x3-H repeats separated by an 8-aa linker, sharing 15 identical anchor positions (including YKTELCR, three cysteines, YG, two phenylalanines, H, and C-terminal E) plus conserved basic and hydrophobic positions.","i":[[153,182,"RYKTELCRPFEESGTCKYGEKCQFAHGFHE"],[191,220,"KYKTELCRTFHTIGFCPYGPRCHFIHNADE"]]}],"s":"MSTTLLSAFYDVDFLCKTEKSLANLNLNNMLDKKAVGTPVAAAPSSGFAPGFLRRHSASNLHALAHPAPSPGSCSPKFPGAANGSSCGSAAAGGPTSYGTLKEPSGGGGTALLNKENKFRDRSFSENGDRSQHLLHLQQQQKGGGGSQINSTRYKTELCRPFEESGTCKYGEKCQFAHGFHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNADERRPAPSGGASGDLRAFGTRDALHLGFPREPRPKLHHSLSFSGFPSGHHQPPGGLESPLLLDSPTSRTPPPPSCSSASSCSSSASSCSSASAASTPSGAPTCCASAAAAAAAALLYGTGGAEDLLAPGAPCAACSSASCANNAFAFGPELSSLITPLAIQTHNFAAVAAAAYYRSQQQQQQQGLAPPAQPPAPPSATLPAGAAAPPSPPFSFQLPRRLSDSPVFDAPPSPPDSLSDRDSYLSGSLSSGSLSGSESPSLDPGRRLPIFSRLSISDD"},{"id":"SEQ_07191","a":"Q86UP3","g":"ZFHX4","d":"Zinc finger homeobox protein 4","L":3567,"m":[{"c":"CxxCxxxxxxxxxφxxH(x){3,5}[HC]","u":"21-23","sp":"dispersed","x":"structured_like","cf":"high","why":"Twenty-one dispersed and locally paired 21-23 aa structured repeats defined by an invariant CxxC motif, a fixed 12-residue central segment with a strictly conserved hydrophobic core position (φ at position 14), and a C-terminal H(x){3,5}[HC] motif.","i":[[280,301,"CFLCKLSFGYIRSFVTHAVHDH"],[615,636,"CPKCDTVLGSSRSLGGHMTMMH"],[646,667,"CPKCNWHYKYQQTLEAHMKEKH"],[701,723,"CEVCNYSTTTKGNLSIHMQSDKH"],[769,791,"CEVCDYETNVARNLRIHMTSEKH"],[919,941,"CKLCNYNTQLKANFQLHCKTDKH"],[975,997,"CNACDYYTNSVDKLRLHTTNHRH"],[1023,1045,"CAVCDYTTKVKLNLVQHVRSVKH"],[1174,1195,"CPYCNYNSRDQSRIQMHVLSQH"],[1203,1224,"CPLCQDVLSNKMHLQLHLTHLH"],[1354,1374,"CNHCSLAFKTMQKLQIHSQYH"],[1382,1403,"CNLCQRSFRTFQALKKHLEAGH"],[1498,1520,"CTVCKESFTQKNILLVHYNSVSH"],[1550,1572,"CSICNVAYSQSSTLEIHMRSVLH"],[1903,1924,"CGTCGKLFSNVLILKSHQEHVH"],[2269,2290,"CKKCNVVFPRIFDLITHQKKQC"],[2450,2470,"CDQCTVAFPTLELWQEHQHMH"],[2632,2653,"CPFCRALFKAKSALESHIRSRH"],[2964,2986,"CTLCGVKYSARLSIRDHIFSKQH"],[3356,3377,"CRKCQMMFTDEDAAVNHQKSFC"],[3400,3422,"CLACDVAISGNEALSQHLQSSLH"]]},{"c":"+[RS]xRTxφ[ST]xxQLx[IV]Lxxx[FY]xxxxxPxxxxxxxψxxxx[GN]Lxx+V[IV]x[VH]WF[QR]N[AT][RL]x+[EA]+[KQ]","u":57,"sp":"dispersed","x":"structured_like","cf":"high","why":"Four ungapped 57-residue structured repeats dispersed across the C-terminal half of the protein, anchored by invariant RT, QL, L, P, L, V, WF, and N residues along with tightly conserved hydrophobic and basic positions.","i":[[2085,2141,"KRPRTRITDDQLKILRAYFDINNSPSEEQIQEMAEKSGLSQKVIKHWFRNTLFKERQ"],[2182,2238,"RSSRTRFTDYQLRVLQDFFDTNAYPKDDEIEQLSTVLNLPTRVIVVWFQNARQKARK"],[2561,2617,"KRLRTTITPEQLEILYEKYLLDSNPTRKMLDHIAREVGLKKRVVQVWFQNTRARERK"],[2885,2941,"KRFRTQMSNLQLKVLKACFSDYRTPTMQECEMLGNEIGLPKRVVQVWFQNARAKEKK"]]},{"c":"Q[PN]QFLx[PS]x[FY][LI]","u":10,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 10-residue motifs located in Q/P-enriched linker regions, anchored by fixed QxQFL N-terminal residues and a C-terminal aromatic-aliphatic [FY][LI] dyad.","i":[[1665,1674,"QPQFLNPAFL"],[1689,1698,"QPQFLFPFYI"],[2475,2484,"QNQFLHSPFL"]]}],"s":"METCDSPPISRQENGQSTSKLCGTTQLDNEVPEKVAGMEPDRENSSTDDNLKTDERKSEALLGFSVENAAATQVTSAKEIPCNECATSFPSLQKYMEHHCPNARLPVLKDDNESEISELEDSDVENLTGEIVYQPDGSAYIIEDSKESGQNAQTGANSKLFSTAMFLDSLASAGEKSDQSASAPMSFYPQIINTFHIASSLGKPFTADQAFPNTSALAGVGPVLHSFRVYDLRHKREKDYLTSDGSAKNSCVSKDVPNNVDLSKFDGCVSDGKRKPVLMCFLCKLSFGYIRSFVTHAVHDHRMTLNDEEQKLLSNKCVSAIIQGIGKDKEPLISFLEPKKSTSVYPHFSTTNLIGPDPTFRGLWSAFHVENGDSLPAGFAFLKGSASTSSSAEQPLGITQMPKAEVNLGGLSSLVVNTPITSVSLSHSSSESSKMSESKDQENNCERPKESNVLHPNGECPVKSEPTEPGDEDEEDAYSNELDDEEVLGELTDSIGNKDFPLLNQSISPLSSSVLKFIEKGTSSSSATVSDDTEKKKQTAAVRASGSVASNYGISGKDFADASASKDSATAAHPSEIARGDEDSSATPHQHGFTPSTPGTPGPGGDGSPGSGIECPKCDTVLGSSRSLGGHMTMMHSRNSCKTLKCPKCNWHYKYQQTLEAHMKEKHPEPGGSCVYCKTGQPHPRLARGESYTCGYKPFRCEVCNYSTTTKGNLSIHMQSDKHLNNVQNLQNGNGEQVFGHSAPAPNTSLSGCGTPSPSKPKQKPTWRCEVCDYETNVARNLRIHMTSEKHMHNMMLLQQNMKQIQHNLHLGLAPAEAELYQYYLAQNIGLTGMKLENPADPQLMINPFQLDPATAAALAPGLGELSPYISDPALKLFQCAVCNKFTSDSLEALSVHVSSERSLPEEEWRAVIGDIYQCKLCNYNTQLKANFQLHCKTDKHMQKYQLVAHIKEGGKSNEWRLKCIAIGNPVHLKCNACDYYTNSVDKLRLHTTNHRHEAALKLYKHLQKQEGAVNPESCYYYCAVCDYTTKVKLNLVQHVRSVKHQQTEGLRKLQLHQQGLAPEEDNLSEIFFVKDCPPNELETASLGARTCDDDLTEQHEEAEGAIKPTAVAEDDEKDTSERDNSEGKNSNKDSVSVAGGTQPLLLAKEEDVATKRSKPTEDNKFCHEQFYQCPYCNYNSRDQSRIQMHVLSQHSVQPVICCPLCQDVLSNKMHLQLHLTHLHSVSPDCVEKLLMTVPVPDVMMPNSMLLPAAASEKSERDTPAAVTAEGSGKYSGESPMDDKSMAGLEDSKANVEVKNEEQKPTKEPLEVSEWNKNSSKDVKIPDTLQDQLNEQQKRQPLSVSDRHVYKYRCNHCSLAFKTMQKLQIHSQYHAIRAATMCNLCQRSFRTFQALKKHLEAGHPELSEAELQQLYASLPVNGELWAESETMSQDDHGLEQEMEREYEVDHEGKASPVGSDSSSIPDDMGSEPKRTLPFRKGPNFTMEKFLDPSRPYKCTVCKESFTQKNILLVHYNSVSHLHKLKKVLQEASSPVPQETNSNTDNKPYKCSICNVAYSQSSTLEIHMRSVLHQTKARAAKLEPSGHVAGGHSIAANVNSPGQGMLDSMSLAAVNSKDTHLDAKELNKKQTPDLISAQPAHHPPQSPAQIQMQLQHELQQQAAFFQPQFLNPAFLPHFPMTPEALLQFQQPQFLFPFYIPGTEFSLGPDLGLPGSATFGMPGMTGMAGSLLEDLKQQIQTQHHVGQTQLQILQQQAQQYQATQPQLQPQKQQQQPPPPQQQQQQQASKLLKQEQSNIVSADCQIMKDVPSYKEAEDISEKPEKPKQEFISEGEGLKEGKDTKKQKSLEPSIPPPRIASGARGNAAKALLENFGFELVIQYNENRQKVQKKGKSGEGENTDKLECGTCGKLFSNVLILKSHQEHVHGQFFPYAALEKFARQYREAYDKLYPISPSSPETPPPPPPPPPLPPAPPQPSSMGPVKIPNTVSTPLQAPPPTPPPPPPPPPPPPPPPPPPPPSAPPQVQLPVSLDLPLFPSIMMQPVQHPALPPQLALQLPQMDALSADLTQLCQQQLGLDPNFLRHSQFKRPRTRITDDQLKILRAYFDINNSPSEEQIQEMAEKSGLSQKVIKHWFRNTLFKERQRNKDSPYNFSNPPITVLEDIRIDPQPTSLEHYKSDASFSKRSSRTRFTDYQLRVLQDFFDTNAYPKDDEIEQLSTVLNLPTRVIVVWFQNARQKARKSYENQAETKDNEKRELTNERYIRTSNMQYQCKKCNVVFPRIFDLITHQKKQCYKDEDDDAQDESQTEDSMDATDQVVYKHCTVSGQTDAAKNAAAPAASSGSGTSTPLIPSPKPEPEKTSPKPEYPAEKPKQSDPSPPSQGTKPALPLASTSSDPPQASTAQPQPQPQPPKQPQLIGRPPSASQTPVPSSPLQISMTSLQNSLPPQLLQYQCDQCTVAFPTLELWQEHQHMHFLAAQNQFLHSPFLERPMDMPYMIFDPNNPLMTGQLLGSSLTQMPPQASSSHTTAPTTVAASLKRKLDDKEDNNCSEKEGGNSGEDQHRDKRLRTTITPEQLEILYEKYLLDSNPTRKMLDHIAREVGLKKRVVQVWFQNTRARERKGQFRAVGPAQSHKRCPFCRALFKAKSALESHIRSRHWNEGKQAGYSLPPSPLISTEDGGESPQKYIYFDYPSLPLTKIDLSSENELASTVSTPVSKTAELSPKNLLSPSSFKAECSEDVENLNAPPAEAGYDQNKTDFDETSSINTAISDATTGDEGNTEMESTTGSSGDVKPALSPKEPKTLDTLPKPATTPTTEVCDDKFLFSLTSPSIHFNDKDGDHDQSFYITDDPDDNADRSETSSIADPSSPNPFGSSNPFKSKSNDRPGHKRFRTQMSNLQLKVLKACFSDYRTPTMQECEMLGNEIGLPKRVVQVWFQNARAKEKKFKINIGKPFMINQGGTEGTKPECTLCGVKYSARLSIRDHIFSKQHISKVRETVGSQLDREKDYLAPTTVRQLMAQQELDRIKKASDVLGLTVQQPGMMDSSSLHGISLPTAYPGLPGLPPVLLPGMNGPSSLPGFPQNSNISAGMLGFPTSATSSPALSLSSAPTKPLLQTPPPPPPPPPPPPSSSLSGQQTEQQNKESEKKQTKPNKVKKIKEEELEATKPEKHPKKEEKISSALSVLGKVVGETHVDPIQLQALQNAIAGDPASFIGGQFLPYFIPGFASYFTPQLPGTVQGGYFPPVCGMESLFPYGPTMPQTLAGLSPGALLQQYQQYQQNLQESLQKQQKQQQEQQQKPVQAKTSKVESDQPQNSNDASETKEDKSTATESTKEEPQLESKSADFSDTYVVPFVKYEFICRKCQMMFTDEDAAVNHQKSFCYFGQPLIDPQETVLRVPVSKYQCLACDVAISGNEALSQHLQSSLHKEKTIKQAMRNAKEHVRLLPHSVCSPNPNTTSTSQSAASSNNTYPHLSCFSMKSWPNILFQASARRAASPPSSPPSLSLPSTVTSSLCSTSGVQTSLPTESCSDESDSELSQKLEDLDNSLEVKAKPASGLDGNFNSIRMDMFSV"},{"id":"SEQ_07203","a":"Q8N9V6","g":"ANKRD53","d":"Ankyrin repeat domain-containing protein 53","L":530,"m":[{"c":"[GS]xxxxx[FL][AVC]xxx[GDN](x){2,6}x[CW]φx[FVY][LC]x(x){2,3}xxxxxxxxxx","u":"33-37","sp":"tandem","x":"structured_like","cf":"high","why":"Five contiguous head-to-tail 33-37 aa structured repeats (residues 107-276) sharing a conserved N-terminal [GS]xxxxx[FL] segment (including canonical TPLHL/TAIHF cores in copies 2-4) and a conserved second hydrophobic helix motif x[CW]φx[FVY][LC]x.","i":[[107,139,"GSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDK"],[140,173,"GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN"],[174,210,"SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCN"],[211,243,"GSTPLHLAARDGLLDCVKVLVQSGANVHAQDAM"],[244,276,"GYKPIDFCKIWNHRACARFLKDAMWKKDKKDFA"]]},{"c":"[PKR]+P[IT]φ","u":5,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Three contiguous 5-residue tandem repeats (residues 371-385) within the C-terminal proline-rich disordered region, anchored by basic residues at positions 1-2, an invariant proline at position 3, [IT] at position 4, and a hydrophobic residue (Y/V/M) at position 5.","i":[[371,375,"PKPIY"],[376,380,"RKPTV"],[381,385,"KRPTM"]]}],"s":"MASAGSTARRAGSGSWHSERGEGRGARPQPTPSGSMQQANKVSLKATWTDAESKQPSQPLPDLADHLSAQATALARPRRPASLTPPRADPSPSKESDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFAREMTKMKMFKSQLTLMEHNYLIEYQKEHKILREAAIRKWLHGKLHPGHSLVSNTKQARATALSKTPEQRESQRSRSFHPSVDARLQCIPQPTEMPKPIYRKPTVKRPTMWNVSNNPARPPTTQISHSQGIRLGVHPDPTPEHDFSSFLEVRPDGHGGARLHTVDGHWVAPVPRLPFEVLLRMLYPRVWPYRMKVPQGFYPISMREVPRKRHLGDNTFWTDTLAMNLRDTFDEAFLAAVRSHQGLPTLPSPQTNP"},{"id":"SEQ_07209","a":"Q9BZ95","g":"NSD3","d":"Histone-lysine N-methyltransferase NSD3","L":1437,"m":[{"c":"C(x){2,7}C(x){0,16}C(x){2,4}C(x){2,3}[FY]H(x){2,4}Cψ(x){7,31}C(x){2,4}C","u":"33-70","sp":"dispersed","x":"structured_like","cf":"high","why":"Five copies (three clustered at residues 704-868 plus two dispersed at 917-949 and 1324-1367) of a cysteine-rich zinc-finger-like domain defined by four paired Cys/His motifs and an invariant [FY]H(x){2,4}Cψ core.","i":[[704,745,"CQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMEC"],[752,798,"CFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHC"],[799,868,"CSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVC"],[917,949,"CEKGGRLLCCESCPASFHPECLSIEMPEGCWNC"],[1324,1367,"CFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQC"]]},{"c":"ψVWxKψGoY[PR]WWP(x){25,26}FFxxxxxxxWVH[EQ]xRVxxY","u":"57-58","sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 57-58 aa dispersed domain copies anchored by an N-terminal ψVWxKψGoY[PR]WWP motif and a C-terminal FFxxxxxxxWVH[EQ]xRVxxY motif.","i":[[273,330,"LVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREY"],[963,1019,"IVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPY"]]}],"s":"MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYPATTEDLPPLTNGYPSSISVYETQTKYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEVQASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAPVSPEYWSKIKCKWESQDHGEEVKE"},{"id":"SEQ_07218","a":"O60469","g":"DSCAM","d":"Cell adhesion molecule DSCAM","L":2012,"m":[{"c":"xxxxxφxC(x){10,14}W(x){32,41}ΩxC(x){18,21}","u":"73-83","sp":"dispersed","x":"structured_like","cf":"high","why":"Ten structured ~73-83 aa repeats anchored by an invariant pair of cysteines, a conserved central W, an aromatic ΩxC motif, and flanking hydrophobic positions; nine copies form a closely spaced N-terminal array while the tenth copy recurs ~415 aa C-terminally.","i":[[39,121,"TTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAV"],[138,218,"GNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVS"],[239,311,"GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVK"],[328,403,"GSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLE"],[421,502,"AEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVR"],[518,595,"GRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKV"],[610,688,"GQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRV"],[704,786,"GKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKI"],[802,884,"GQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQE"],[1300,1378,"MKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQV"]]},{"c":"P(x){19,23}W(x){44,54}Yxφxψx[AV]x[NT]x[AIV]Gx[SGA]xx[SQ]xxφxxx","u":"91-99","sp":"dispersed","x":"structured_like","cf":"high","why":"Six structured ~91-99 aa repeats initiated by a conserved P and internal W anchor and terminating in an ungapped 23-residue Yxφxψx[AV]x[NT]x[AIV]Gx[SGA]xx[SQ]xxφxxx block, arranged as four tandem copies followed by two C-terminal copies after an intervening repeat unit.","i":[[885,978,"PPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTIT"],[984,1082,"PDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITT"],[1088,1183,"PSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTR"],[1189,1279,"PGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVE"],[1379,1469,"PPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAK"],[1475,1566,"PQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATL"]]}],"s":"MWILALSLFQSFANVFSEDLHSSLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNEGLKMLVTISCILVGVLLLFVLLLVVRRRRREQRLKRLRDAKSLAEMLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDDRSTVLLTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTRRNAKAGPTARNRYASQWTLNRPHPTISAHTLTTDWRLPTPRAAGSVDKESDSYSVSPSQDTDRARSSMVSTESASSTYEELARAYEHAKMEEQLRHAKFTITECFISDTSSEQLTAGTNEYTDSLTSSTPSESGICRFTASPPKPQDGGRVMNMAVPKAHRPGDLIHLPPYLRMDFLLNRGGPGTSRDLSLGQACLEPQKSRTLKRPTVLEPIPMEAASSASSTREGQSWQPGAVATLPQREGAELGQAAKMSSSQESLLDSRGHLKGNNPYAKSYTLV"},{"id":"SEQ_07223","a":"Q3KNS1","g":"PTCHD3","d":"Patched domain-containing protein 3","L":954,"m":[{"c":"[DQ]DAP[LPR][LPR][EP]","u":7,"sp":"periodic","x":"disordered_like","cf":"high","why":"Four clustered 7-residue repeats separated by short 1-3 aa linkers within the N-terminal P/E/D/S-enriched disordered tail, anchored by an invariant DAP core with conserved [DQ] N-terminal and [LPR]/[EP] C-terminal positions.","i":[[64,70,"QDAPLPE"],[72,78,"DDAPPRP"],[82,88,"DDAPRLP"],[92,98,"DDAPLPE"]]}],"s":"MPWVEPKPRPGPEQKPKLTKPDSATGPQWYQESQESESEGKQPPPGPLAPPKSPEPSGPLASEQDAPLPEGDDAPPRPSMLDDAPRLPLELDDAPLPEEETPEPTAICRHRHRCHTDCLEGLLSRTFQWLGWQVGAHPWIFLLAPLMLTAALGTGFLYLPKDEEEDLEEHYTPVGSPAKAERRFVQGHFTTNDSYRFSASRRSTEANFVSLLVVSYSDSLLDPATFAEVSKLDGAVQDLRVAREKGSQIQYQQVCARYRALCVPPNPILYAWQVNKTLNLSSISFPAYNHGRHPLYLTGFFGGYILGGSLGMGQLLLRAKAMRLLYYLKTEDPEYDVQSKQWLTHLLDQFTNIKNILALKKIEVVHFTSLSRQLEFEATSVTVIPVFHLAYILIILFAVTSCFRFDCIRNKMCVAAFGVISAFLAVVSGFGLLLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWHKTNLADDIRERMSNVYSKAAVSITITTITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFGAFMALDGKREVVCLCWLKKADPKWPSFKKFCCFPFGSVPDEHGTDIHPISLFFRDYFGPFLTRSESKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYFNVEENYFSDYGPRVMVIVTKKVDYWDKDVRQKLENCTKIFEKNVYVDKNLTEFWLDAYVQYLKGNSQDPNEKNTFMNNIPDFLSNFPNFQHDINISSSNEIISSRGFIQTTDVSSSAKKKILLFQLRRIAEDCQIPLMVYNQAFIYFDQYAAILEDTVRNVLVASAAMFIVSLLLIPYPLCSLWVTFAIGSVIVGVTGFMAFWKVNLDSISMINLVICIGFSFDFSVHISYAFVSSSQPSVNQKSVEALYLLGYPVLQSAISTIIGVCVLAAAKAYIFRTFFKIMFLVMIFGAAHGLIFIPVFLTFFGRFI"},{"id":"SEQ_07227","a":"O95622","g":"ADCY5","d":"Adenylate cyclase type 5","L":1261,"m":[{"c":"ψψFA[DS]I[AE]xF[ST][ES](x){13,17}LNEψφAxFDxψφ[AS](x){10,13}GxxYφ[AC]φSGL(x){34,39}M+ψGψxxG[PR]Vx[AC]GVψGφRKxQΩDψW[GS]NxVoψAo[HR]M-[AS]xGx[AP]xRIxψTxxxφoφL(x){22,23}[ET]xFL","u":"172-183","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of a large (~172-183 aa) globular domain separated by a central transmembrane/linker region, featuring five conserved secondary-structure blocks including a 54-residue ungapped core (M+ψG...QΩDψW...RIxψT...φoφL) separated by minor loop-length variations.","i":[[470,641,"ILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFL"],[1072,1254,"VMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFL"]]}],"s":"MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS"},{"id":"SEQ_07228","a":"Q9BRD0","g":"BUD13","d":"BUD13 homolog","L":619,"m":[{"c":"R[KRH]x[RQ]H[DGN][ST][PS][DG]x[SA]P","u":12,"sp":"tandem","x":"disordered_like","cf":"high","why":"Tandem array of 12-aa basic/proline-directed repeats in a central disordered region (residues 117-276) anchored by invariant R1, H5, and P12 alongside conserved basic, acidic, and S/T/P positions (with two 1-aa-indelled degenerate units skipped to preserve exact register).","i":[[117,128,"RHFRHDTPDSSP"],[129,140,"RRVRHGTPDPSP"],[141,152,"RKDRHDTPDPSP"],[153,164,"RRARHDTPDPSP"],[178,189,"RRIRHDSSDTSP"],[191,202,"RRARHDSPDPSP"],[204,215,"RRPQHNSSGASP"],[216,227,"RRVRHDSPDPSP"],[265,276,"RRARHDSPDLAP"]]},{"c":"D[SP]D[LI]S[PS]PR","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five non-overlapping 8-aa repeats dispersed across an adjacent C-terminal disordered segment (residues 321-410) with invariant D1, D3, S5, P7, and R8 anchors flanking a conserved aliphatic L/I4 core.","i":[[321,328,"DPDISPPR"],[353,360,"DSDLSSPR"],[371,378,"DSDLSPPR"],[387,394,"DSDLSPPR"],[403,410,"DSDLSPPR"]]}],"s":"MAAAPPLSKAEYLKRYLSGADAGVDRGSESGRKRRKKRPKPGGAGGKGMRIVDDDVSWTAISTTKLEKEEEEDDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFRHDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAAHMYSGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYAETVFRDKSGRKRNLKLERLEQRRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQEREGDPMANFIKKNKAKENKNKKVRPRYSGPAPPPNRFNIWPGYRWDGVDRSNGFEQKRFARLASKKAVEELAYKWSVEDM"},{"id":"SEQ_07254","a":"Q96MT3","g":"PRICKLE1","d":"Prickle-like protein 1","L":831,"m":[{"c":"C[ES][QAT]C(x){15,20}[CH]WH(x){2,4}[CH]FxCxxCxxxLx[DG]xxΩφx[QK][DQ]G[KRQ][IP][HFY]C(x){2,3}[HC]","u":"52-57","sp":"periodic","x":"structured_like","cf":"high","why":"Three 52-57 aa structured zinc-coordinating repeats separated by regular 8-aa linkers, anchored by N-terminal CxxC, central [CH]WH and [CH]FxCxxC knuckles, invariant L and G with an aromatic-hydrophobic dyad (Ωφ) in a fixed 16-aa core, and C-terminal [HFY]C(x){2,3}[HC].","i":[[126,182,"CEQCGLKINGGEVAVFASRAGPGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCGRH"],[191,242,"CSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCCGC"],[251,306,"CETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKASLLGCPFLPKQGQIYCSKTC"]]}],"s":"MPLEMEPKMSKLAFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQSLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAVMHAVCEQCGLKINGGEVAVFASRAGPGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKASLLGCPFLPKQGQIYCSKTCSLGEDVHASDSSDSAFQSARSRDSRRSVRMGKSSRSADQCRQSLLLSPALNYKFPGLSGNADDTLSRKLDDLSLSRQGTSFASEEFWKGRVEQETPEDPEEWADHEDYMTQLLLKFGDKSLFQPQPNEMDIRASEHWISDNMVKSKTELKQNNQSLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRRLQELELDHGASGYNHDETQWYEDSLECLSDLKPEQSVRDSMDSLALSNITGASVDGENKPRPSLYSLQNFEEMETEDCEKMSNMGTLNSSMLHRSAESLKSLSSELCPEKILPEEKPVHLPVLRRSKSQSRPQQVKFSDDVIDNGNYDIEIRQPPMSERTRRRVYNFEERGSRSHHHRRRRSRKSRSDNALNLVTERKYSPKDRLRLYTPDNYEKFIQNKSAREIQAYIQNADLYGQYAHATSDYGLQNPGMNRFLGLYGEDDDSWCSSSSSSSDSEEEGYFLGQPIPQPRPQRFAYYTDDLSSPPSALPTPQFGQRTTKSKKKKGHKGKNCIIS"},{"id":"SEQ_07268","a":"Q6WRI0","g":"IGSF10","d":"Immunoglobulin superfamily member 10","L":2623,"m":[{"c":"φxCxxxGxPx[PA]xxxW(x){20,29}G[TSK][LF]xφxxxxxx-x[GA]xΩxCx[AS]x[NS](x){13,14}","u":"70-80","sp":"dispersed","x":"structured_like","cf":"high","why":"Twelve 70-80 aa beta-sandwich domain repeats (two N-proximal copies and a C-terminal 10-repeat array separated by a long S/T/P-rich central stalk), anchored by invariant C3, G7, P9, and W15 N-terminal residues, an internal G[TSK][LF]xφ motif, and an invariant -x[GA]xΩxCx[AS]x[NS] disulfide core.","i":[[495,569,"LNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRITVV"],[593,662,"LPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSV"],[1668,1740,"LPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSV"],[1765,1838,"LKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVI"],[1862,1935,"LPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTME"],[1961,2033,"LNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSL"],[2058,2137,"VDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVI"],[2161,2231,"LDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVV"],[2259,2331,"FDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVL"],[2357,2428,"LNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEI"],[2452,2524,"LHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIV"],[2548,2623,"LHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI"]]},{"c":"xψx[LM]xxNxψxx[LI]xxxx[FV][SYV]x[LM]xxLx","u":24,"sp":"tandem","x":"structured_like","cf":"high","why":"Six N-terminal 24-aa leucine-rich repeats (five strictly head-to-tail copies followed by a sixth copy after an 8-aa loop) defined by invariant Asn7 and Leu23 anchors alongside conserved aliphatic/hydrophobic positions at 2, 4, 9, 12, 17, and 20.","i":[[61,84,"RINLGYNSLVRLMETDFSGLTKLE"],[85,108,"LLMLHSNGIHTIPDKTFSDLQALQ"],[109,132,"VLKMSYNKVRKLQKDTFYGLRSLT"],[133,156,"RLHMDHNNIEFINPEVFYGLNFLR"],[157,180,"LVHLEGNQLTKLHPDTFVSLSYLQ"],[189,212,"FLYLSDNFLTSLPQEMVSYMPDLD"]]}],"s":"MKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPDVIKCKKDRSPSSAQQCPLCMNPRTSKGKPLAMVSAAAFQCAKPTIDSSLKSKSLTILEDSSSAFISPQGFMAPFGSLTLNMTDQSGNEANMVCSIQKPSRTSPIAFTEENDYIVLNTSFSTFLVCNIDYGHIQPVWQILALYSDSPLILERSHLLSETPQLYYKYKQVAPKPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEMRPVKHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQRPLEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTSKRHNYRELTLQRRGDSTHRRFRENRRHFPPSARRIDPQHWAALLEKAKKNAMPDKRENTTVSPPPVVTQLPNIPGEEDDSSGMLALHEEFMVPATKALNLPARTVTADSRTISDSPMTNINYGTEFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKNINPTMSSQIQGTTNQHSSTVFPLLLGATEFQDSDQMGRGREHFQSRPPITVRTMIKDVNVKMLSSTTNKLLLESVNTTNSHQTSVREVSEPRHNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRRFGRQRKIGGRGRIISPYRTPVLRRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPRERLTTATAALSFPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTGAVMTYAPTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTIIAITRFSRRKIPWQQNFVNNHNPKGRLRNQHKVSLQKSTAVMLPKTSPALPRDKVSPFHFTTLSTSVMQIPSNTLTTAHHTTTKTHNPGSLPTKKELPFPPLNPMLPSIISKDSSTKSIISTQTAIPATTPTFPASVITYETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGFTTPTAMTPPVLTTAETSVKPSVSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIASETTLSSKSHQSTTTRKAIIRHSTIPPFLSSSATLMPVPISPPFTQRAVTDNVATPISGLMTNTVVKLHESSRHNAKPQQLVAEVATSPKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKSQNSKLTPSPWAENQFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSDFDKKPVQEATTSKLLPFDSLSRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI"},{"id":"SEQ_07274","a":"Q6UWP8","g":"SBSN","d":"Suprabasin","L":590,"m":[{"c":"φG[QH]Gφ[HN][HN][AG]φ[GS][QE][AVG][GW][KNR]E[ATV][GED]+","u":18,"sp":"tandem","x":"mixed","cf":"high","why":"Extensive 27-copy tandem array of 18-residue repeats spanning residues 32-529 (interrupted only by an 11-aa partial repeat at 86-96 and a 1-aa gap at 133), anchored by invariant Glu15, highly conserved Gly2/Gly4, hydrophobic positions 1/5/9, His/Asn dyad at positions 6-7, and basic C-terminal residue 18.","i":[[32,49,"VIEGINRGLSNAEREVGK"],[50,67,"ALDGINSGITHAGREVEK"],[68,85,"VFNGLSNMGSHTGKELDK"],[97,114,"VAHEINHGIGQAGKEAEK"],[115,132,"LGHGVNNAAGQVGKEADK"],[134,151,"IHHGVHHGANQAGSEAGK"],[152,169,"FGQGVDNAAGQAGNEAGR"],[170,187,"FGQGVHHAAGQAGNEAGR"],[188,205,"FGQGVHHAAGQAGNEAGR"],[206,223,"FGQGAHHGLSEGWKETEK"],[224,241,"FGQGIHHAAGQVGKEAEK"],[242,259,"FGQGAHHAAGQAGNEAGR"],[260,277,"FGQGVHHGLSEGWKETEK"],[278,295,"FGQGVHHTAGQVGKEAEK"],[296,313,"FGQGAHHAAGQAGNEAGR"],[314,331,"FGQGAHHAAGQAGNEAGR"],[332,349,"FGQGVHHGLSEGWKETEK"],[350,367,"FGQGVHHAASQFGKETEK"],[368,385,"LGHGVHHGVNEAWKEAEK"],[386,403,"FGQGVHHAASQVGKEEDR"],[404,421,"VVQGLHHGVSQAGREAGQ"],[422,439,"FGHDIHHTAGQAGKEGDI"],[440,457,"AVHGVQPGVHEAGKEAGQ"],[458,475,"FGQGVHHTLEQAGKEADK"],[476,493,"AVQGFHTGVHQAGKEAEK"],[494,511,"LGQGVNHAADQAGKEVEK"],[512,529,"LGQGAHHAAGQAGKELQN"]]}],"s":"MHLARLVGSCSLLLLLGALSGWAASDDPIEKVIEGINRGLSNAEREVGKALDGINSGITHAGREVEKVFNGLSNMGSHTGKELDKGVQGLNHGMDKVAHEINHGIGQAGKEAEKLGHGVNNAAGQVGKEADKLIHHGVHHGANQAGSEAGKFGQGVDNAAGQAGNEAGRFGQGVHHAAGQAGNEAGRFGQGVHHAAGQAGNEAGRFGQGAHHGLSEGWKETEKFGQGIHHAAGQVGKEAEKFGQGAHHAAGQAGNEAGRFGQGVHHGLSEGWKETEKFGQGVHHTAGQVGKEAEKFGQGAHHAAGQAGNEAGRFGQGAHHAAGQAGNEAGRFGQGVHHGLSEGWKETEKFGQGVHHAASQFGKETEKLGHGVHHGVNEAWKEAEKFGQGVHHAASQVGKEEDRVVQGLHHGVSQAGREAGQFGHDIHHTAGQAGKEGDIAVHGVQPGVHEAGKEAGQFGQGVHHTLEQAGKEADKAVQGFHTGVHQAGKEAEKLGQGVNHAADQAGKEVEKLGQGAHHAAGQAGKELQNAHNGVNQASKEANQLLNGNHQSGSSSHQGGATTTPLASGASVNTPFINLPALWRSVANIMP"},{"id":"SEQ_07298","a":"P22626","g":"HNRNPA2B1","d":"Heterogeneous nuclear ribonucleoproteins A2/B1","L":353,"m":[{"c":"KLFψGGψxx-TxExxLR[ND]YΩE[QE]ΩGKψxxxxψψxDxxSx+xRGFGFVTFxxxxxVDxφψφx+xH[ST]I[DN]G[RH]xφEx++Aψ[AS]R","u":78,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 78-aa globular repeats separated by a 13-aa linker, anchored by invariant KLFψGGψ, LR[ND]YΩE[QE]ΩGKψ, RGFGFVTF, H[ST]I[DN]G, and C-terminal E++Aψ[AS]R motifs.","i":[[22,99,"KLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAR"],[113,190,"KLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSR"]]}],"s":"MEKTLETVPLERKKREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGGGNFGGSPGYGGGRGGYGGGGPGYGNQGGGYGGGYDNYGGGNYGSGNYNDFGNYNQQPSNYGPMKSGNFGGSRNMGGPYGGGNYGPGGSGGSGGYGGRSRY"},{"id":"SEQ_07299","a":"Q4KMP7","g":"TBC1D10B","d":"TBC1 domain family member 10B","L":808,"m":[{"c":"KQEKER[QE]","u":7,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Six nearly identical 7-aa tandem copies (6 of 7 positions strictly invariant: KQEKER[QE], interrupted once by a 4-aa KERQ turn) embedded within a C-terminal E/K/R/Q-rich charged helical rod.","i":[[723,729,"KQEKERQ"],[730,736,"KQEKERQ"],[737,743,"KQEKERE"],[748,754,"KQEKERE"],[755,761,"KQEKERE"],[762,768,"KQEKERQ"]]}],"s":"METGTAPLVAPPRRHGAPAAPSPPPRGSRAGPVVVVAPGPPVTTATSAPVTLVAPGEARPAWVPGSAETSAPAPAPAPAPAPAVTGSTVVVLTLEASPEAPKPQLPSGPESPEPAAVAGVETSRALAAGADSPKTEEARPSPAPGPGTPTGTPTRTPSRTAPGALTAKPPLAPKPGTTVASGVTARSASGQVTGGHGAAAATSASAGQAPEDPSGPGTGPSGTCEAPVAVVTVTPAPEPAENSQDLGSTSSLGPGISGPRGQAPDTLSYLDSVSLMSGTLESLADDVSSMGSDSEINGLALRKTDKYGFLGGSQYSGSLESSIPVDVARQRELKWLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEVTNLPVTEALIERENAAQLKKWRETRGELQYRPSRRLHGSRAIHEERRRQQPPLGPSSSLLSLPGLKSRGSRAAGGAPSPPPPVRRASAGPAPGPVVTAEGLHPSLPSPTGNSTPLGSSKETRKQEKERQKQEKERQKQEKEREKERQKQEKEREKQEKEREKQEKERQKQEKKAQGRKLSLRRKADGPPGPHDGGDRPSAEARQDAYF"},{"id":"SEQ_07315","a":"O75112","g":"LDB3","d":"LIM domain-binding protein 3","L":727,"m":[{"c":"[TAS][PT][LK]C[GAH][HKG]C[ND]xxψ(x){1,2}G(x){1,2}φψxAψ[GR][RQH][ST]WHx[ET][EC]F[TVI]CAφC[KH]xxφxxxxFxx[EK]x[NGD]x[PV]φC[EK]+[CDH]φxoφ[FN]","u":"59-61","sp":"tandem","x":"structured_like","cf":"high","why":"Three head-to-tail tandem 59-61 aa Cys/His-rich structured repeats anchored by conserved CxxC, Aψ[GR][RQH][ST]WH, F[TVI]CAφC, F, and C[EK]+[CDH] zinc-coordinating motifs with a 2-aa loop expansion in the third copy.","i":[[548,606,"TPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFF"],[607,665,"APLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLF"],[666,726,"STKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHAHTIN"]]},{"c":"[TN]P[SA]P[AVS][PV][ATN]Y","u":8,"sp":"tandem","x":"disordered_like","cf":"high","why":"Six contiguous head-to-tail 8-aa repeats in the central Pro/Ser/Thr-rich disordered region anchored by invariant P2, P4, and C-terminal Y8 positions (predominantly TPSPAPAY).","i":[[430,437,"TPSPAPAY"],[438,445,"TPSPAPAY"],[446,453,"TPSPVPTY"],[454,461,"TPSPAPAY"],[462,469,"TPSPAPNY"],[470,477,"NPAPSVAY"]]}],"s":"MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMTHLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVAPSPSPEARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGARDLLGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGVGLPGGSLPIKDLAVDSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSSTPIEHAPVCTSQATTPLLPASAQPPAAASPSAASPPLATAAAHTAIASASTTAPASSPADSPRPQASSYSPAVAASSAPATHTSYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSPGANYSPTPYTPSPAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYNPAPSVAYSGGPAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPRGGPAYTPAGPQVPPLARGTVQRAERFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHAHTINL"},{"id":"SEQ_07339","a":"O43426","g":"SYNJ1","d":"Polyphosphatidylinositol phosphatase SYNJ1","L":1573,"m":[{"c":"Px[PIL]PxR","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five dispersed 6-residue proline-rich motif copies across the C-terminal disordered region (residues 1062-1382), anchored by invariant P at positions 1 and 4, a conserved [PIL] residue at position 3, and an invariant C-terminal R at position 6.","i":[[1062,1067,"PSLPIR"],[1120,1125,"PAPPQR"],[1196,1201,"PTIPPR"],[1284,1289,"PQPPPR"],[1377,1382,"PPIPAR"]]}],"s":"MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEVRKVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTTDNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLDDSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVNLLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLDYGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAKLKDGARSVTRTIQNNFFDSSKQEAIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSIKSSLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELLNRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGGIGAPPSPGVARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQVKTNGISDGKRESPLKIDPFEDLSFNLLAVSKAQLSVQTSPVPTPDPKRLIQLPSATQSNVLSSVSCMPTMPPIPARSQSQENMRSSPNPFITGLTRTNPFSDRTAAPGNPFRAKSEESEATSWFSKEEPVTISPFPSLQPLGHNKSRASSSLDGFKDSFDLQGQSTLKISNPKGWVTFEEEEDFGVKGKSKSACSDLLGNQPSSFSGSNLTLNDDWNKGTNVSFCVLPSRRPPPPPVPLLPPGTSPPVDPFTTLASKASPTLDFTER"},{"id":"SEQ_07342","a":"Q5VZL5","g":"ZMYM4","d":"Zinc finger MYM-type protein 4","L":1548,"m":[{"c":"CxxC(x){18,23}[FL]CxxxCxxx[YF]","u":"32-37","sp":"dispersed","x":"structured_like","cf":"high","why":"Ten dispersed 32-37 aa cysteine-rich repeats (separated by 9-75 aa linkers) share an invariant CxxC...CxxxC four-cysteine core flanked by a conserved hydrophobic [FL] before the third cysteine and a C-terminal aromatic [YF] anchor.","i":[[341,373,"CSGCKKILQKGQTAYQRKGSTQLFCSTLCLTGY"],[389,425,"CSSCSKDILNPKDVISAQFENTTTSKDFCSQSCLSTY"],[444,475,"CSMCQKNAVIRHEVNYQNVVHKLCSDACFSKF"],[486,521,"CENCGGYCYSGSGQCHMLQIEGQSKKFCSSSCITAY"],[531,565,"CALCKSLRSSAEMIENTNSLGKTELFCSVNCLSAY"],[579,611,"CNSCKTSAIPQYHLAMSDGSIRNFCSYSCVVAF"],[687,719,"CQHCNRLFATKPELLDYKGKMFQFCGKNCSDEY"],[729,760,"CEYCKIEKIVKETVRFSGADKSFCSEGCKLLY"],[775,806,"CSYCLQTSPKLVQNNLGGKVEEFCCEECMSKY"],[816,847,"CDACKRQGKLSESLKWRGEMKHFCNLLCILMF"]]}],"s":"MAEREVESGPRKRFEQKSGAVFDEIVENCGGIMDTEMSEDIDHNLTPTLDSMSYGMPNQTGSENSLLDEDDYFLNSGDLAGIPVVGSDNEDEQDFSSKDNLVSSIHTDDSLEVERRVTQHESDNENEIQIQNKLKKDFPKQFDQVSVFKSIRKDFSLVRENSKETFSGKEKNRDLTYEREKRLDKPHKDLDSRLKSSFFDKAANQVEETLHTHLPQTPETNFRDSSYPFANKESIGSELGNSFASNIRIKEEPLDDEYDKAMAPQQGLLDKIKDEPDNAQEYSHGQQQKTQEGELKISAVFSVSGSPLAPQLTTGFQPSLASSGMNKMLPSVPATAVRVSCSGCKKILQKGQTAYQRKGSTQLFCSTLCLTGYTVPPARPPPPLTKKTCSSCSKDILNPKDVISAQFENTTTSKDFCSQSCLSTYELKKKPIVTINTNSISTKCSMCQKNAVIRHEVNYQNVVHKLCSDACFSKFRSANNLTMNCCENCGGYCYSGSGQCHMLQIEGQSKKFCSSSCITAYKQKSAKITPCALCKSLRSSAEMIENTNSLGKTELFCSVNCLSAYRVKMVTSAGVQVQCNSCKTSAIPQYHLAMSDGSIRNFCSYSCVVAFQNLFNKPTGMNSSVVPLSQGQVIVSIPTGSTVSAGGGSTSAVSPTSISSSAAAGLQRLAAQSQHVGFARSVVKLKCQHCNRLFATKPELLDYKGKMFQFCGKNCSDEYKKINNVMAMCEYCKIEKIVKETVRFSGADKSFCSEGCKLLYKHDLAKRWGNHCKMCSYCLQTSPKLVQNNLGGKVEEFCCEECMSKYTVLFYQMAKCDACKRQGKLSESLKWRGEMKHFCNLLCILMFCNQQSVCDPPSQNNAANISMVQAASAGPPSLRKDSTPVIANVVSLASAPAAQPTVNSNSVLQGAVPTVTAKIIGDASTQTDALKLPPSQPPRLLKNKALLCKPITQTKATSCKPHTQNKECQTEDTPSQPQIIVVPVPVPVFVPIPLHLYTQYAPVPFGIPVPMPVPMLIPSSMDSEDKVTESIEDIKEKLPTHPFEADLLEMAEMIAEDEEKKTLSQGESQTSEHELFLDTKIFEKDQGSTYSGDLESEAVSTPHSWEEELNHYALKSNAVQEADSELKQFSKGETEQDLEADFPSDSFDPLNKGQGIQARSRTRRRHRDGFPQPRRRGRKKSIVAVEPRSLIQGAFQGCSVSGMTLKYMYGVNAWKNWVQWKNAKEEQGDLKCGGVEQASSSPRSDPLGSTQDHALSQESSEPGCRVRSIKLKEDILSCTFAELSLGLCQFIQEVRRPNGEKYDPDSILYLCLGIQQYLFENGRIDNIFTEPYSRFMIELTKLLKIWEPTILPNGYMFSRIEEEHLWECKQLGAYSPIVLLNTLLFFNTKYFQLKNVTEHLKLSFAHVMRRTRTLKYSTKMTYLRFFPPLQKQESEPDKLTVGKRKRNEDDEVPVGVEMAENTDNPLRCPVRLYEFYLSKCSESVKQRNDVFYLQPERSCVPNSPMWYSTFPIDPGTLDTMLTRILMVREVHEELAKAKSEDSDVELSD"},{"id":"SEQ_07350","a":"Q9Y6N7","g":"ROBO1","d":"Roundabout homolog 1","L":1651,"m":[{"c":"Px[DN]xxV[AST]x[GD]x[PST]φxφxC(x){3,4}GxPxP[TA][IV]xW[KRY]+(x){17,26}LxI(x){6,8}DxGxY[VIT]Cx[AGT]x[NT]xxG(x){6,9}xψx[IV]x","u":"81-95","sp":"periodic","x":"structured_like","cf":"high","why":"Five consecutive 81-95 aa structured repeats in the N-terminal region separated by short 7-14 aa linkers, anchored by invariant C, GxPxP, W, LxI, DxGxY[VIT]C, and C-terminal G/hydrophobic beta-strand positions.","i":[[74,168,"PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL"],[176,259,"PSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL"],[268,348,"PSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ"],[357,446,"PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVT"],[461,543,"PVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ"]]},{"c":"P[ST](x){16,32}ψ[SH]W(x){11,14}Yx[IV](x){23,28}I[KP]xLx[PK][GN]φxYxφx[VA][RA](x){5,7}Gφx[DS][PE]x[QK][IF]x","u":"89-110","sp":"periodic","x":"structured_like","cf":"high","why":"Three consecutive 89-110 aa structured repeats following the N-terminal repeat array and separated by 6-10 aa linkers, sharing conserved N-terminal P[ST], core ψ[SH]W and Yx[IV] aromatics, an I[KP]xLx[PK][GN]φxYxφx[VA][RA] motif, and a C-terminal Gφx[DS][PE]x[QK][IF]x segment.","i":[[561,649,"PSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS"],[659,768,"PTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFA"],[775,869,"PSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFI"]]}],"s":"MKWKHVPFLVMISLLSLSPNHLFLAQLIPDPEDVERGNDHGTPIPTSDNDDNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES"},{"id":"SEQ_07351","a":"Q9NUD5","g":"ZCCHC3","d":"Zinc finger CCHC domain-containing protein 3","L":403,"m":[{"c":"C[FN]xCGx[RE][GT]Hφ[SF]xxC","u":14,"sp":"periodic","x":"structured_like","cf":"high","why":"Three 14-aa C-terminal repeats separated by regular 4-5 aa linkers, strictly anchored by invariant CxxCGxxxHxxxxC cysteines, glycine, and histidine alongside conserved flanking physicochemical positions.","i":[[335,348,"CFKCGSRTHMSGSC"],[353,366,"CFRCGEEGHLSPYC"],[372,385,"CNLCGKRGHAFAQC"]]}],"s":"MATGGGAEEERKRGRPQLLPPARPAARGEEADGGREKMGWAQVVKNLAEKKGEFREPRPPRREEESGGGGGSAGLGGPAGLAAPDLGDFPPAGRGDPKGRRRDPAGEAVDPRKKKGAAEAGRRKKAEAAAAAMATPARPGEAEDAAERPLQDEPAAAAGPGKGRFLVRICFQGDEGACPTRDFVVGALILRSIGMDPSDIYAVIQIPGSREFDVSFRSAEKLALFLRVYEEKREQEDCWENFVVLGRSKSSLKTLFILFRNETVDVEDIVTWLKRHCDVLAVPVKVTDRFGIWTGEYKCEIELRQGEGGVRHLPGAFFLGAERGYSWYKGQPKTCFKCGSRTHMSGSCTQDRCFRCGEEGHLSPYCRKGIVCNLCGKRGHAFAQCPKAVHNSVAAQLTGVAGH"},{"id":"SEQ_07355","a":"Q9HCJ0","g":"TNRC6C","d":"Trinucleotide repeat-containing gene 6C protein","L":1936,"m":[{"c":"[NGS][STG][GAS]W[GDE]x[PST][PST]","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"25 dispersed (with locally clustered) 8-aa GW/WG-type motifs distributed across the extensive S/T/N/G/P-rich disordered regions, anchored by an invariant central W flanked by an N-terminal small/polar tripeptide ([NGS][STG][GAS]) and a C-terminal G/D/E position followed by acidic/polar and P/S/T-rich residues.","i":[[150,157,"NSHWGQQP"],[456,463,"NSVWGLSP"],[505,512,"GNAWDSGP"],[535,542,"SGAWGHPS"],[550,557,"NGEWGKPP"],[570,577,"STGWESPS"],[656,663,"NTGWGQTP"],[716,723,"VSGWVNAP"],[730,737,"NTGWGDSN"],[744,751,"PGVWGDSI"],[778,785,"SPTWGEPP"],[826,833,"GSGWDADS"],[837,844,"GSGWNDTT"],[848,855,"NSGWGNST"],[862,869,"GTNWGETL"],[899,906,"GTGWIGGP"],[917,924,"ATGWEEPS"],[938,945,"TSAWGDPS"],[1007,1014,"SSGWGEMP"],[1021,1028,"ENSWGEPS"],[1038,1045,"TAAWGKPP"],[1048,1055,"GSGWGDHP"],[1120,1127,"CSSWGNAP"],[1730,1737,"SSTWGASP"],[1902,1909,"SSLWGPPS"]]}],"s":"MEEKKKKKQEEKKKKEGAQKKAADQKTKVPEPTKTCSSQPQPAGTSTSTSTSTISSSNNGKRASASGQQPAASRYLPREVPPRFRQQEQKQLLKRGQPLPTGTLTSVSPTQGAGPAGVSPPPLPGAGTQHHPSKLQPDLSHSGLADHYENSHWGQQPTYRSEANCSWDKVIIDRTDKEAWPSITGTETESASECTTDTDSASNCGSENSSMATGSAQGNFTGHTKKTNGNNGTNGALVQSPSNQSALGAGGANSNGSAARVWGVATGSSSGLAHCSVSGGDGKMDTMIGDGRSQNCWGASNSNAGINLNLNPNANPAAWPVLGHEGTVATGNPSSICSPVSAIGQNMGNQNGNPTGTLGAWGNLLPQESTEPQTSTSQNVSFSAQPQNLNTDGPNNTNPMNSSPNPINAMQTNGLPNWGMAVGMGAIIPPHLQGLPGANGSSVSQVSGGSAEGISNSVWGLSPGNPATGNSNSGFSQGNGDTVNSALSAKQNGSSSAVQKEGSGGNAWDSGPPAGPGILAWGRGSGNNGVGNIHSGAWGHPSRSTSNGVNGEWGKPPNQHSNSDINGKGSTGWESPSVTSQNPTVQPGGEHMNSWAKAASSGTTASEGSSDGSGNHNEGSTGREGTGEGRRRDKGIIDQGHIQLPRNDLDPRVLSNTGWGQTPVKQNTAWEFEESPRSERKNDNGTEAWGCAATQASNSGGKNDGSIMNSTNTSSVSGWVNAPPAAVPANTGWGDSNNKAPSGPGVWGDSISSTAVSTAAAAKSGHAWSGAANQEDKSPTWGEPPKPKSQHWGDGQRSNPAWSAGGGDWADSSSVLGHLGDGKKNGSGWDADSNRSGSGWNDTTRSGNSGWGNSTNTKANPGTNWGETLKPGPQQNWASKPQDNNVSNWGGAASVKQTGTGWIGGPVPVKQKDSSEATGWEEPSPPSIRRKMEIDDGTSAWGDPSNYNNKTVNMWDRNNPVIQSSTTTNTTTTTTTTTSNTTHRVETPPPHQAGTQLNRSPLLGPVSSGWGEMPNVHSKTENSWGEPSSPSTLVDNGTAAWGKPPSSGSGWGDHPAEPPVAFGRAGAPVAASALCKPASKSMQEGWGSGGDEMNLSTSQWEDEEGDVWNNAASQESTSSCSSWGNAPKKGLQKGMKTSGKQDEAWIMSRLIKQLTDMGFPREPAEEALKSNNMNLDQAMSALLEKKVDVDKRGLGVTDHNGMAAKPLGCRPPISKESSVDRPTFLDKDGGLVEEPTPSPFLPSPSLKLPLSHSALPSQALGGIASGLGMQNLNSSRQIPSGNLGMFGNSGAAQARTMQQPPQPPVQPLNSSQPSLRAQVPQFLSPQVQAQLLQFAAKNIGLNPALLTSPINPQHMTMLNQLYQLQLAYQRLQIQQQMLQAQRNVSGSMRQQEQQVARTITNLQQQIQQHQRQLAQALLVKQPPPPPPPPHLSLHPSAGKSAMDSFPSHPQTPGLPDLQTKEQQSSPNTFAPYPLAGLNPNMNVNSMDMTGGLSVKDPSQSQSRLPQWTHPNSMDNLPSAASPLEQNPSKHGAIPGGLSIGPPGKSSIDDSYGRYDLIQNSESPASPPVAVPHSWSRAKSDSDKISNGSSINWPPEFHPGVPWKGLQNIDPENDPDVTPGSVPTGPTINTTIQDVNRYLLKSGGSSPPSSQNATLPSSSAWPLSASGYSSSFSSIASAPSVAGKLSDIKSTWSSGPTSHTQASLSHELWKVPRNSTAPTRPPPGLTNPKPSSTWGASPLGWTSSYSSGSAWSTDTSGRTSSWLVLRNLTPQIDGSTLRTLCLQHGPLITFHLNLTQGNAVVRYSSKEEAAKAQKSLHMCVLGNTTILAEFAGEEEVNRFLAQGQALPPTSSWQSSSASSQPRLSAAGSSHGLVRSDAGHWNAPCLGGKGSSELLWGGVPQYSSSLWGPPSADDSRVIGSPTPLTTLLPGDLLSGESL"},{"id":"SEQ_07362","a":"Q96PQ0","g":"SORCS2","d":"VPS10 domain-containing receptor SorCS2","L":1159,"m":[{"c":"ψxx[ST]xDxGxxΩ","u":11,"sp":"dispersed","x":"structured_like","cf":"high","why":"Five ungapped 11-residue copies dispersed across the structured N-terminal domain (residues 181-596) share invariant D6 and G8 anchors, a conserved [ST]4 position, an N-terminal large aliphatic residue (L/M), and a C-terminal aromatic residue (W/Y/F).","i":[[181,191,"LWRSSDFGTSY"],[231,241,"LFLSADEGATF"],[272,282,"LYVSSDLGKKW"],[544,554,"MYITSDCGHTW"],[586,596,"LKFSVDEGLTW"]]}],"s":"MAHRGPSRASKGPGPTARAPSPGAPPPPRSPRSRPLLLLLLLLGACGAAGRSPEPGRLGPHAQLTRVPRSPPAGRAEPGGGEDRQARGTEPGAPGPSPGPAPGPGEDGAPAAGYRRWERAAPLAGVASRAQVSLISTSFVLKGDATHNQAMVHWTGENSSVILILTKYYHADMGKVLESSLWRSSDFGTSYTKLTLQPGVTTVIDNFYICPTNKRKVILVSSSLSDRDQSLFLSADEGATFQKQPIPFFVETLIFHPKEEDKVLAYTKESKLYVSSDLGKKWTLLQERVTKDHVFWSVSGVDADPDLVHVEAQDLGGDFRYVTCAIHNCSEKMLTAPFAGPIDHGSLTVQDDYIFFKATSANQTKYYVSYRRNEFVLMKLPKYALPKDLQIISTDESQVFVAVQEWYQMDTYNLYQSDPRGVRYALVLQDVRSSRQAEESVLIDILEVRGVKGVFLANQKIDGKVMTLITYNKGRDWDYLRPPSMDMNGKPTNCKPPDCHLHLHLRWADNPYVSGTVHTKDTAPGLIMGAGNLGSQLVEYKEEMYITSDCGHTWRQVFEEEHHILYLDHGGVIVAIKDTSIPLKILKFSVDEGLTWSTHNFTSTSVFVDGLLSEPGDETLVMTVFGHISFRSDWELVKVDFRPSFSRQCGEEDYSSWELSNLQGDRCIMGQQRSFRKRKSTSWCIKGRSFTSALTSRVCECRDSDFLCDYGFERSSSSESSTNKCSANFWFNPLSPPDDCALGQTYTSSLGYRKVVSNVCEGGVDMQQSQVQLQCPLTPPRGLQVSIQGEAVAVRPGEDVLFVVRQEQGDVLTTKYQVDLGDGFKAMYVNLTLTGEPIRHRYESPGIYRVSVRAENTAGHDEAVLFVQVNSPLQALYLEVVPVIGLNQEVNLTAVLLPLNPNLTVFYWWIGHSLQPLLSLDNSVTTRFSDTGDVRVTVQAACGNSVLQDSRVLRVLDQFQVMPLQFSKELDAYNPNTPEWREDVGLVVTRLLSKETSVPQELLVTVVKPGLPTLADLYVLLPPPRPTRKRSLSSDKRLAAIQQVLNAQKISFLLRGGVRVLVALRDTGTGAEQLGGGGGYWAVVVLFVIGLFAAGAFILYKFKRKRPGRTVYAQMHNEKEQEMTSPVSHSEDVQGAVQGNHSGVVLSINSREMHSYLVS"},{"id":"SEQ_07371","a":"Q9UKA4","g":"AKAP11","d":"A-kinase anchor protein 11","L":1901,"m":[{"c":"[FY][AS]xx[LV][AVS]xxxφxxxxxxφ","u":17,"sp":"dispersed","x":"mixed","cf":"high","why":"Dispersed 17-residue amphipathic helical motif occurring 11 times across the protein, anchored by an invariant N-terminal [FY][AS]xx[LV][AVS] signature, conserved hydrophobic positions at residues 10 and 17, and a small residue (A/G/S/T) at position 13, separated by variable-length disordered linkers.","i":[[553,569,"FAADLVEKSFGSAFKDL"],[646,662,"FAADLAEELVFEGIMEV"],[689,705,"YAKDLSESVIQEAFIEL"],[875,891,"FSAAVVHTIVNETLESM"],[938,954,"FADRLSKSIIKHSIDKS"],[1198,1214,"FAEALATHILSLATEMA"],[1259,1275,"FAGDLAAEVITEAEKIA"],[1367,1383,"YANRLAYRSVKSGLQEA"],[1457,1473,"FSTSLVHSITKDAKEEL"],[1543,1559,"YAKKVVDDTLELTLGST"],[1684,1700,"FAESLATETMTAAVTNV"]]}],"s":"MATFRNNHMKTKASVRKSFSEDVFQSVKSLLQSQKELCSVTAEDCLQQDEHANLTEVTFLGFNEETDAAHIQDLAAVSLELPDILNSLHFCSLNENEIICMKNINKPLDISSDPLNQSHPSGMLCVMRVSPTSPRLRIDFIFSLLSKYATGIRYTLDTFLHQKHQLETTDEDDDDTNQSVSSIEDDFVTAFEHLEEEETSKPYNDGMNITVLRSQCDAASQTVTGHHLETHDLKILISSGQQKSLAKPSTSSVNVLGHKELPSVKTSVTTSISEPWTQRSFYRSSNASDKDSDLQKTFFSSSPAYSSESECSSPSPVIFLDEEGYQKSLKAKLELPKIPVMKDDIEDSDSEVSEFFDSFDQFDELEQTLETCLFNKDPVIGKSSQRKGHKHGKSCMNPQKFKFDRPALPANVRKPTPRKPESPYGNLCDAPDSPRPVKASREDSGLFSPIRSSAFSPLGGCTPAECFCQTDIGGDRIHENHDSVYYTYEDYAKSISCEVLGSVLRTHHTNTLSNINSIKHGENKTVTFKHGNLDQKNKSKNKSLMIKDSIQKFAADLVEKSFGSAFKDLQKGVSSCTNALYHLAIKLTSSVLQMAFDELRRQRAFSLKERAISGLANFLVSEALSNALKDLQYVKKQIFTNTVARFAADLAEELVFEGIMEVCQFSYPQTPASPQCGSFDFEDKVVKLYAKDLSESVIQEAFIELSQVDVTFTTKAAVSVSTDNIKYVSAESVVPSTQAVTFSPSFHNQAIMVTKPVQEYKKEYTVQQALFCTSGIVTSIPVPLAGSALLPYHISSTACQAKAHLSSDDSNSNGDSAQVHIATKNREEKAACLRNICLPSEHNPGNQNDFKPTNDDIEMQSSSKLPNDPAIISNFSAAVVHTIVNETLESMTSLEVTKMVDERTDYLTKSLKEKTPPFSHCDQAVLQCSEASSNKDMFADRLSKSIIKHSIDKSKSVIPNIDKNAVYKESLPVSGEESQLTPEKSPKFPDSQNQLTHCSLSAAKDCVPECKVSMVHGSSLETLPSCPAVTGQKSDLKESAKDQPLKKHNLNSTSLEALSFGQENPFPHSHTFSSTALTCVDGLHVEDKQKVRDRNVIPDTPPSTPLVPSRASSEWDIKKLTKKLKGELAKEFAPATPPSTPHNSSVGSLSENEQNTIEKEEFMLKLMRSLSEEVESSESGELPEVDVKSEHSGKKVQFAEALATHILSLATEMAASHLDNKIIQEPKVKNPCLNVQSQRSVSPTFLNPSDENLKTLCNFAGDLAAEVITEAEKIAKVRNCMLFKQKKNSCYADGDEDYKVEEKLDIEAVVHPREVDPFILSLPPSSCMSGLMYKYPSCESVTDEYAGHLIQILKQEGGNSELIMDQYANRLAYRSVKSGLQEAAKTTKVQCNSRMFPVPSSQVKTNKELLMFSNKEHHQEADKKRQSKRNEGYFCKNQTCERTLDPYRNEVSQLYSFSTSLVHSITKDAKEELTASLVGLPKSLTDSCLFEKSGYEEDNECHVTPELPKSLQPSSQNHRFYHSTGSLNGYGCGDNVVQAVEQYAKKVVDDTLELTLGSTVFRVSETTKSADRVTYAEKLSPLTGQACRYCDLKELHNCTGNSSQHFFRQGSLASSKPASNPKFSSRYQKSRIFHLSVPQIHVNLDKKAVLAEKIVAEAIEKAERELSSTSLAADSGIGQEGASFAESLATETMTAAVTNVGHAVSSSKEIEDFQSTESVSSQQMNLSIGDDSTGSWSNLSFEDEHQDESSSFHHLSESNGNSSSWSSLGLEGDLYEDNLSFPTSDSDGPDDKDEEHEDEVEGLGQDGKTLLITNIDMEPCTVDPQLRIILQWLIASEAEVAELYFHDSANKEFMLLSKQLQEKGWKVGDLLQAVLQYYEVMEKASSEERCKSLFDWLLENA"},{"id":"SEQ_07376","a":"Q9ULU8","g":"CADPS","d":"Calcium-dependent secretion activator 1","L":1353,"m":[{"c":"NLPx[VN]","u":5,"sp":"tandem","x":"disordered_like","cf":"high","why":"Four tandem 5-aa repeats (three head-to-tail copies of NLP[NK]V followed after a 1-residue P linker by a fourth NLPVN copy) located in a proline-rich central linker, anchored by a strictly invariant NLP tripeptide and a conserved V/N C-terminal position.","i":[[1014,1018,"NLPNV"],[1019,1023,"NLPNV"],[1024,1028,"NLPKV"],[1030,1034,"NLPVN"]]}],"s":"MLDPSSSEEESDEIVEEESGKEVLGSAPSGARLSPSRTSEGSAGSAGLGGGGAGAGAGVGAGGGGGSGASSGGGAGGLQPSSRAGGGRPSSPSPSVVSEKEKEELERLQKEEEERKKRLQLYVFVMRCIAYPFNAKQPTDMARRQQKISKQQLQTVKDRFQAFLNGETQIMADEAFMNAVQSYYEVFLKSDRVARMVQSGGCSANDSREVFKKHIEKRVRSLPEIDGLSKETVLSSWMAKFDAIYRGEEDPRKQQARMTASAASELILSKEQLYEMFQNILGIKKFEHQLLYNACQLDNPDEQAAQIRRELDGRLQMADQIARERKFPKFVSKEMENMYIEELKSSVNLLMANLESMPVSKGGEFKLQKLKRSHNASIIDMGEESENQLSKSDVVLSFSLEVVIMEVQGLKSLAPNRIVYCTMEVEGGEKLQTDQAEASKPTWGTQGDFSTTHALPAVKVKLFTESTGVLALEDKELGRVILHPTPNSPKQSEWHKMTVSKNCPDQDLKIKLAVRMDKPQNMKHSGYLWAIGKNVWKRWKKRFFVLVQVSQYTFAMCSYREKKAEPQELLQLDGYTVDYTDPQPGLEGGRAFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSHKPVPPTQVQKLNAKGGNVPQLDAPISQFYADRAQKHGMDEFISSNPCNFDHASLFEMVQRLTLDHRLNDSYSCLGWFSPGQVFVLDEYCARNGVRGCHRHLCYLRDLLERAENGAMIDPTLLHYSFAFCASHVHGNRPDGIGTVTVEEKERFEEIKERLRVLLENQITHFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPQEEVKTVIRKCLEQAALVNYSRLSEYAKIEENQKDAENVGRLITPAKKLEDTIRLAELVIEVLQQNEEHHAEPHVDKGEAFAWWSDLMVEHAETFLSLFAVDMDAALEVQPPDTWDSFPLFQLLNDFLRTDYNLCNGKFHKHLQDLFAPLVVRYVDLMESSIAQSIHRGFERESWEPVKSLTSNLPNVNLPNVNLPKVPNLPVNIPLGIPQMPTFSAPSWMAAIYDADNGSGTSEDLFWKLDALQTFIRDLHWPEEEFGKHLEQRLKLMASDMIESCVKRTRIAFEVKLQKTSRSTDFRVPQSICTMFNVMVDAKAQSTKLCSMEMGQEHQYHSKIDELIEETVKEMITLLVAKFVTILEGVLAKLSRYDEGTLFSSFLSFTVKAASKYVDVPKPGMDVADAYVTFVRHSQDVLRDKVNEEMYIERLFDQWYNSSMNVICTWLTDRMDLQLHIYQLKTLIRMVKKTYRDFRLQGVLDSTLNSKTYETIRNRLTVEEATASVSEGGGLQGISMKDSDEEDEEDD"},{"id":"SEQ_07377","a":"P23471","g":"PTPRZ1","d":"Receptor-type tyrosine-protein phosphatase zeta","L":2315,"m":[{"c":"KNR[YT]xxIxxx[DH][RE]SRV(x){9,12}TDYINA[NS]Y[VI][DM]GYxxxxxΩI[AI][AT]Q[GH]PL[KL][SH]T[AI][EK]DFWRMIW-HN[VA][EQ][LV]ψVMI[TP](x){11,12}YWP(x){80,84}GP[VM][VI]VHxxxGxxx[TA]GTΩxxLxx[ML][LM][QH]Qψ[QE][HK]E[GN][TS]V[ND]ψΩxφ[LA]K[HM]I[RN][SL]xRxxψφx[TD][EI]EQYxFψxx[TV]ψψxφψ[LS]","u":"234-242","sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 234-242 aa C-terminal globular domain duplications separated by a 56-aa linker, sharing invariant KNR...SRV, TDYINA, DFWRMIW-HN, YWP, GP[VM][VI]VH, and QYxFψ core signature blocks.","i":[[1753,1994,"KNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAIL"],[2051,2284,"KNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVS"]]}],"s":"MRILKRFLACIQLLCVCRLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPKQSPINIDEDLTQVNVNLKKLKFQGWDKTSLENTFIHNTGKTVEINLTNDYRVSGGVSEMVFKASKITFHWGKCNMSSDGSEHSLEGQKFPLEMQIYCFDADRFSSFEEAVKGKGKLRALSILFEVGTEENLDFKAIIDGVESVSRFGKQAALDPFILLNLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFKDTVSISESQLAVFCEVLTMQQSGYVMLMDYLQNNFREQQYKFSRQVFSSYTGKEEIHEAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGAILNNLLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPELIGTEEIIKEEEEGKDIEEGAIVNPGRDSATNQIRKKEPQISTTTHYNRIGTKYNEAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVTELPPHTVEGTSASLNDGSKTVLRSPHMNLSGTAESLNTVSITEYEEESLLTSFKLDTGAEDSSGSSPATSAIPFISENISQGYIFSSENPETITYDVLIPESARNASEDSTSSGSEESLKDPSMEGNVWFPSSTDITAQPDVGSGRESFLQTNYTEIRVDESEKTTKSFSAGPVMSQGPSVTDLEMPHYSTFAYFPTEVTPHAFTPSSRQQDLVSTVNVVYSQTTQPVYNGETPLQPSYSSEVFPLVTPLLLDNQILNTTPAASSSDSALHATPVFPSVDVSFESILSSYDGAPLLPFSSASFSSELFRHLHTVSQILPQVTSATESDKVPLHASLPVAGGDLLLEPSLAQYSDVLSTTHAASETLEFGSESGVLYKTLMFSQVEPPSSDAMMHARSSGPEPSYALSDNEGSQHIFTVSYSSAIPVHDSVGVTYQGSLFSGPSHIPIPKSSLITPTASLLQPTHALSGDGEWSGASSDSEFLLPDTDGLTALNISSPVSVAEFTYTTSVFGDDNKALSKSEIIYGNETELQIPSFNEMVYPSESTVMPNMYDNVNKLNASLQETSVSISSTKGMFPGSLAHTTTKVFDHEISQVPENNFSVQPTHTVSQASGDTSLKPVLSANSEPASSDPASSEMLSPSTQLLFYETSASFSTEVLLQPSFQASDVDTLLKTVLPAVPSDPILVETPKVDKISSTMLHLIVSNSASSENMLHSTSVPVFDVSPTSHMHSASLQGLTISYASEKYEPVLLKSESSHQVVPSLYSNDELFQTANLEINQAHPPKGRHVFATPVLSIDEPLNTLINKLIHSDEILTSTKSSVTGKVFAGIPTVASDTFVSTDHSVPIGNGHVAITAVSPHRDGSVTSTKLLFPSKATSELSHSAKSDAGLVGGGEDGDTDDDGDDDDDDRGSDGLSIHKCMSCSSYRESQEKVMNDSDTHENSLMDQNNPISYSLSENSEEDNRVTSVSSDSQTGMDRSPGKSPSANGLSQKHNDGKEENDIQTGSALLPLSPESKAWAVLTSDEESGSGQGTSDSLNENETSTDFSFADTNEKDADGILAAGDSEITPGFPQSPTSSVTSENSEVFHVSEAEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSLDSNGAALPDGNIAESLESLV"},{"id":"SEQ_07380","a":"Q9UHL9","g":"GTF2IRD1","d":"General transcription factor II-I repeat domain-containing protein 1","L":959,"m":[{"c":"LR[KE]xV[EQK]xψF[ND]xxY[AGS][EK]A[LI]GxxxxVx[VL]PYxxφxxxP[EGD]x[VL]x[VI]xG[LI]P[EDP][GKD][IL][PAS][FL]+xP[CNA]xΩ[GD]xxxLxxIL[EAK]xxxx[IV]x[FM]xψx[RN]","u":75,"sp":"dispersed","x":"structured_like","cf":"high","why":"Five gapless 75-aa globular repeat units separated by variable disordered linkers (22-148 aa), anchored by invariant LR, V, F, Y, A, G, V, PY, P, G, P, +xP, L, and IL positions plus conserved hydrophobic cores.","i":[[128,202,"LRKMVEEVFDVLYSEALGRASVVPLPYERLLREPGLLAVQGLPEGLAFRRPAEYDPKALMAILEHSHRIRFKLKR"],[351,425,"LRECVQILFNSRYAEALGLDHMVPVPYRKIACDPEAVEIVGIPDKIPFKRPCTYGVPKLKRILEERHSIHFIIKR"],[565,639,"LRKQVELLFNTRYAKAIGISEPVKVPYSKFLMHPEELFVVGLPEGISLRRPNCFGIAKLRKILEASNSIQFVIKR"],[705,779,"LREQVQDLFNKKYGEALGIKYPVQVPYKRIKSNPGSVIIEGLPPGIPFRKPCTFGSQNLERILAVADKIKFTVTR"],[802,876,"LREQVKELFNEKYGEALGLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVIIN"]]}],"s":"MALLGKRCDVPTNGCGPDRWNSAFTRKDEIITSLVSALDSMCSALSKLNAEVACVAVHDESAFVVGTEKGRMFLNARKELQSDFLRFCRGPPWKDPEAEHPKKVQRGEGGGRSLPRSSLEHGSDVYLLRKMVEEVFDVLYSEALGRASVVPLPYERLLREPGLLAVQGLPEGLAFRRPAEYDPKALMAILEHSHRIRFKLKRPLEDGGRDSKALVELNGVSLIPKGSRDCGLHGQAPKVPPQDLPPTATSSSMASFLYSTALPNHAIRELKQEAPSCPLAPSDLGLSRPMPEPKATGAQDFSDCCGQKPTGPGGPLIQNVHASKRILFSIVHDKSEKWDAFIKETEDINTLRECVQILFNSRYAEALGLDHMVPVPYRKIACDPEAVEIVGIPDKIPFKRPCTYGVPKLKRILEERHSIHFIIKRMFDERIFTGNKFTKDTTKLEPASPPEDTSAEVSRATVLDLAGNARSDKGSMSEDCGPGTSGELGGLRPIKIEPEDLDIIQVTVPDPSPTSEEMTDSMPGHLPSEDSGYGMEMLTDKGLSEDARPEERPVEDSHGDVIRPLRKQVELLFNTRYAKAIGISEPVKVPYSKFLMHPEELFVVGLPEGISLRRPNCFGIAKLRKILEASNSIQFVIKRPELLTEGVKEPIMDSQGTASSLGFSPPALPPERDSGDPLVDESLKRQGFQENYDARLSRIDIANTLREQVQDLFNKKYGEALGIKYPVQVPYKRIKSNPGSVIIEGLPPGIPFRKPCTFGSQNLERILAVADKIKFTVTRPFQGLIPKPDEDDANRLGEKVILREQVKELFNEKYGEALGLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVIINQLQPFAEICNDAKVPAKDSSIPKRKRKRVSEGNSVSSSSSSSSSSSSNPDSVASANQISLVQWPMYMVDYAGLNVQLPGPLNY"},{"id":"SEQ_07384","a":"P16989","g":"YBX3","d":"Y-box-binding protein 3","L":372,"m":[{"c":"[RN][RP]xYR[RP]xY[RYN]xR[RG]x[PG][PR][PY][RHP]","u":17,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed 17-aa R/Y/P-rich modules across the disordered C-terminal region separated by 23-43 aa linkers, sharing invariant YR, Y, and R anchors in register along with a C-terminal proline-arginine cluster.","i":[[174,190,"RRRYRRGYYGRRRGPPR"],[225,241,"RPQYRPQYRQRRFPPYH"],[284,300,"NPTYRPRYRSRGPPRPR"],[326,342,"RRGYRRPYNYRRRPRPP"]]}],"s":"MSEAGEATTTTTTTLPQAPTEAAAAAPQDPAPKSPVGSGAPQAAAPAPAAHVAGNPGGDAAPAATGTAAAASLATAAGSEDAEKKVLATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPDGVPVEGSRYAADRRRYRRGYYGRRRGPPRNYAGEEEEEGSGSSEGFDPPATDRQFSGARNQLRRPQYRPQYRQRRFPPYHVGQTFDRRSRVLPHPNRIQAGEIGEMKDGVPEGAQLQGPVHRNPTYRPRYRSRGPPRPRPAPAVGEAEDKENQQATSGPNQPSVRRGYRRPYNYRRRPRPPNAPSQDGKEAKAGEAPTENPAPPTQQSSAE"},{"id":"SEQ_07400","a":"Q9NVR5","g":"DNAAF2","d":"Protein kintoun","L":837,"m":[{"c":"EψxφxxxxP(x){0,2}ψLR[ST]xxxxAxxxxxxψxxx(x){11,24}SLPY[SP]ψxxGRxxAxxoxxRxxψφxxψ","u":"65-80","sp":"dispersed","x":"structured_like","cf":"medium","why":"Two dispersed copies of a 65-80 aa globular domain separated by a proline-rich linker, sharing an N-terminal EψxφxxxxP-turn and ψLR[ST]xxxxA helix followed after a variable loop by an ungapped 26-aa C-terminal core anchored by SLPY, GR, A, R, and conserved aliphatic/hydrophobic positions.","i":[[66,145,"EVRFVHPEPGHVLRTSLDGARRCFVNVCSNALVGAPSSRPGSGGDRGAAPGSHWSLPYSLAPGREYAGRSSSRYMVYDVV"],[282,346,"ELVITIELPLLRSAEQAALEVTRKLLCLDSRKPDYRLRLSLPYPVDDGRGKAQFNKARRQLVVTL"]]}],"s":"MAKAAASSSLEDLDLSGEEVQRLTSAFQDPEFRRMFSQYAEELTDPENRRRYEAEITALERERGVEVRFVHPEPGHVLRTSLDGARRCFVNVCSNALVGAPSSRPGSGGDRGAAPGSHWSLPYSLAPGREYAGRSSSRYMVYDVVFHPDALALARRHEGFRQMLDATALEAVEKQFGVKLDRRNAKTLKAKYKGTPEAAVLRTPLPGVIPARPDGEPKGPLPDFPYPYQYPAAPGPRAPSPPEAALQPAPTEPRYSVVQRHHVDLQDYRCSRDSAPSPVPHELVITIELPLLRSAEQAALEVTRKLLCLDSRKPDYRLRLSLPYPVDDGRGKAQFNKARRQLVVTLPVVLPAARREPAVAVAAAAPEESADRSGTDGQACASAREGEAGPARSRAEDGGHDTCVAGAAGSGVTTLGDPEVAPPPAAAGEERVPKPGEQDLSRHAGSPPGSVEEPSPGGENSPGGGGSPCLSSRSLAWGSSAGRESARGDSSVETREESEGTGGQRSACAMGGPGTKSGEPLCPPLLCNQDKETLTLLIQVPRIQPQSLQGDLNPLWYKLRFSAQDLVYSFFLQFAPENKLSTTEPVISISSNNAVIELAKSPESHGHWREWYYGVNNDSLEERLFVNEENVNEFLEEVLSSPFKQSMSLTPPLIEVLQVTDNKIQINAKLQECSNSDQLQGKEERVNEESHLTEKEYIEHCNTPTTDSDSSIAVKALQIDSFGLVTCFQQESLDVSQMILGKSQQPESKMQSEFIKEKSATCSNEEKDNLNESVITEEKETDGDHLSSLLNKTTVHNIPGFDSIKETNMQDGSVQVIKDHVTNCAFSFQNSLLYDLD"},{"id":"SEQ_07430","a":"O15018","g":"PDZD2","d":"PDZ domain-containing protein 2","L":2839,"m":[{"c":"xxxxψxxxK[ET](x){2,7}GL[GS][FIL](x){10,29}xx[IL]x[VI]xxψxxx[GS]xAxxx[GS]xψxx[GR]Dx[IL]LxψN[GS]xxψx[GH]φxxxx[AV]xxxφ(x){4,6}[GH]xxxLxψxx[KRH]","u":"87-112","sp":"dispersed","x":"structured_like","cf":"high","why":"Six dispersed globular domain repeats (four in the N-terminal third and two at the C-terminus; the first copy carries a basic loop insertion) anchored by N-terminal ψxxxK and GL[GS][FIL] motifs, an un-gapped 37-residue core containing fixed A and [GR]Dx[IL]LxψN[GS], and a C-terminal [GH]xxxLxψxx[KRH] strand.","i":[[67,178,"EICTVYLTKELGDTETVGLSFGNIPVFGDYGEKRRGGKKRKTHQGPVLDVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRR"],[331,418,"RIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASK"],[583,672,"VISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTK"],[725,813,"IVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRH"],[2620,2706,"VCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKK"],[2747,2835,"DALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRKH"]]}],"s":"MPITQDNAVLHLPLLYQWLQNSLQEGGDGPEQRLCQAAIQKLQEYIQLNFAVDESTVPPDHSPPEMEICTVYLTKELGDTETVGLSFGNIPVFGDYGEKRRGGKKRKTHQGPVLDVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFKHKAHSTYNGNSSNSSEPGETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGCEVSSDPSTELENGPDPELGNGHVFQLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAPLTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEEGSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQRKVGCYDANDASDEEEFDREGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEERPRKTLVSKAISAPLLGSSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSGSSSAPKLEYTVRTDTQSPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGSQTVNLTGRANDPCDLDSRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELASALSHLDASHLTENLPKAASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVSRPENPSQPASPRVTKCKARSPVRLPHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRVAALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLEGADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAARSPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQPSVLDSINPDKHFTVNKNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSSDPESLTEAPRASARDGWSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQAAICPASAKVLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHADISTSQNHRPSCAEETTEVTSASSAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLDDETLNQYETSINAAASLSSFSVDVPKNGESVLENLHISESQDLDDLLQKPKMIARRPIMAWFKEINKHNQGTHLRSKTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLENKDLSKKSPAEMLLTNGQKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISPQTSHKTLSKAVSQRLHVADHEDPDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIRTFVSPLTSPKPVPEQGMWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAASRNGMSVAGNRQSEPRLASHVAADTAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAVSETVCGNKPAESDRRGGCLAQGNCQEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSRSFSMAKLASSSSSLQTAIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPATRTYSMPAQFSSHFGREGHPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSVKPLLDTSRNLPATDEGDIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIKSFENLANADRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSCSENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLASPVKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRRSPGPPAGGVSCPEKGGNRACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQLLVSAGDQQRLQSVLSSVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRKHRNSS"},{"id":"SEQ_07452","a":"Q6ZUX3","g":"TOGARAM2","d":"TOG array regulator of axonemal microtubules protein 2","L":1019,"m":[{"c":"xxxxxφxxxx[STA]x(x){7,8}[VI]xxx[AV]φxx[LF]xxφφxxφ","u":"35-36","sp":"dispersed","x":"structured_like","cf":"medium","why":"Five well-conserved 35-36 aa helix-turn-helix units within a larger C-terminal alpha-solenoid domain share a conserved Helix A hydrophobic/small register and a strongly constrained 16-aa amphipathic Helix B core ([VI]xxx[AV]φxx[LF]xxφφxxφ) separated by a 7-8 residue turn.","i":[[527,562,"GKLHDVCLVVTGEVTNLRSKVSHLAISTLGDLFQAL"],[604,639,"TLARSLVVLTSAGVYHRNPLIRKYAAEHLSAVLEQI"],[802,837,"AHLVQVFDAFTPRLQDSNKKVNQWALESFAKMIPLL"],[843,878,"PMLLSIIITVADNLNSKNSGIYAAAVAVLDAMVESL"],[902,936,"VTDRLAVLVASVYPRKPQAVERHVLPILWHFLNTA"]]}],"s":"MGTRDDVPEAKVLVPVAVYCGSIPRTSAGPRVLPPGSINSSLPHGEGSLQPEPRALLNNEEPSQLLRGLGQLGGLKLDTPSKGWQARNGHPRNLRALSLGDQPLVLLPSPESEANSVARDTIQIKDKLKKRRLSEGLAASSRASLDPGGGPQGVPLHSTIPRATSQRLLRVPRPMPLIQSIPTTPEASGVKEKGLDLPGSIPGPHELRPGAQEAQISWQYLHCNDEKMQKSLGAIVIPPIPKARTVAATPSRVPGSLPSPLPPGQGVLTGLRAPRTRLARGSGPREKTPASLEPKPLASPIRDRPAAAKKPALPFSQSAPTLTAFSFDCAREACPPLKEEDQKEIGTKIQVTISKSAREKMQLKQMKEMELLRRLEEPRTGQELTSQCLGSQRAFMKEGLLPLRGSGTLSVPTRLSGPCRNDVSIILRKWASRASLPSIPISRQEPRFARHASANSLPAVLTLGSPEWEEEEEMDLRACKELRPFSNPELGLRDALQCLNSSDWQMKEKGLVSIQRLAACHSEVLTGKLHDVCLVVTGEVTNLRSKVSHLAISTLGDLFQALKKNMDQEAEEIARCLLQKMADTNEFIQRAAGQSLRAMVENVTLARSLVVLTSAGVYHRNPLIRKYAAEHLSAVLEQIGAEKLLSGTRDSTDMLVHNLVRLAQDSNQDTRFYGRKMVNILMANTKFDAFLKQSLPSYDLQKVMAAIKQQGIEDNDELPSAKGRKVLRSLVVCENGLPIKEGLSCNGPRLVGLRSTLQGRGEMVEQLRELTRLLEAKDFRSRMEGVGQLLELCKAKTELVTAHLVQVFDAFTPRLQDSNKKVNQWALESFAKMIPLLRESLHPMLLSIIITVADNLNSKNSGIYAAAVAVLDAMVESLDNLCLLPALAGRVRFLSGRAVLDVTDRLAVLVASVYPRKPQAVERHVLPILWHFLNTATRNGTLPGPSGNIRGVVCRLSRSLQEHMGSRLLDFAASQPKHVLKTLQELLDSESLGGSRKATDRGVAPDSKTTGSSYPFQLD"},{"id":"SEQ_07453","a":"P34910","g":"EVI2B","d":"Protein EVI2B","L":448,"m":[{"c":"[SDP][LFI]PPxxxx","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Six dispersed proline-rich linear motifs clustered in the C-terminal S/D/E/P-enriched disordered tail (residues 337-446), all sharing a conserved [SDP][LFI]PP N-terminal core (4/6 S at position 1, bulky hydrophobic L/F/I at position 2, invariant PP at positions 3-4) followed by acidic (D/E) and aliphatic/aromatic residues.","i":[[337,344,"DLPPPPPL"],[372,379,"SLPPSLDC"],[394,401,"SFPPLDSL"],[404,411,"PLPPVDFM"],[427,434,"SIPPNSDQ"],[439,446,"SLPPPPAE"]]}],"s":"MDPKYFILILFCGHLNNTFFSKTETITTEKQSQPTLFTSSMSQVLANSQNTTGNPLGQPTQFSDTFSGQSISPAKVTAGQPTPAVYTSSEKPEAHTSAGQPLAYNTKQPTPIANTSSQQAVFTSARQLPSARTSTTQPPKSFVYTFTQQSSSVQIPSRKQITVHNPSTQPTSTVKNSPRSTPGFILDTTSNKQTPQKNNYNSIAAILIGVLLTSMLVAIIIIVLWKCLRKPVLNDQNWAGRSPFADGETPDICMDNIRENEISTKRTSIISLTPWKPSKSTLLADDLEIKLFESSENIEDSNNPKTEKIKDQVNGTSEDSADGSTVGTAVSSSDDADLPPPPPLLDLEGQESNQSDKPTMTIVSPLPNDSTSLPPSLDCLNQDCGDHKSEIIQSFPPLDSLNLPLPPVDFMKNQEDSNLEIQCQEFSIPPNSDQDLNESLPPPPAELL"},{"id":"SEQ_07454","a":"Q8TD57","g":"DNAH3","d":"Dynein axonemal heavy chain 3","L":4116,"m":[{"c":"G[PDI]x[GM][TGS]G+oxxx[KN]x[LFS][ALT](x){33,64}φφ[CIF]φDxx[NVI]","u":"56-87","sp":"periodic","x":"structured_like","cf":"high","why":"Four large structured repeats recur at ~280-365 aa intervals across residues 1428-2493, each anchored by an N-terminal glycine-rich G[PDI]x[GM][TGS]G+o motif with invariant G1/G6 and conserved basic-polar positions, a 33-64 aa internal segment, and a C-terminal hydrophobic strand followed by an invariant Asp (φφ[CIF]φDxx[NVI]).","i":[[1429,1484,"GPAGTGKTETTKDLAKALAKQCVVFNCSDGLDYKAMGKFFKGLAQAGAWACFDEFN"],[1710,1796,"GDPMGGKTSAYKVLAAALGDLHAANQMEEFAVEYKIINPKAITMGQLYGCFDQVSHEWMDGVLANAFREQASSLSDDRKWIIFDGPV"],[2074,2144,"GPTGTGKSAITNNFLLHLPKNTYLPNCINFSARTSANQTQDIIMSKLDRRRKGLFGPPIGKKAVVFVDDLN"],[2434,2496,"GIGGSGRQSAAKLSTFMNAYELYQIEITKNYAGNDWREDLKKIILQVGVATKSTVFLFADNQI"]]}],"s":"MGATGRLELTLAAPPHPGPAFQRSKARETQGEEEGSEMQIAKSDSIHHMSHSQGQPELPPLPASANEEPSGLYQTVMSHSFYPPLMQRTSWTLAAPFKEQHHHRGPSDSIANNYSLMAQDLKLKDLLKVYQPATISVPRDRTGQGLPSSGNRSSSEPMRKKTKFSSRNKEDSTRIKLAFKTSIFSPMKKEVKTSLTFPGSRPMSPEQQLDVMLQQEMEMESKEKKPSESDLERYYYYLTNGIRKDMIAPEEGEVMVRISKLISNTLLTSPFLEPLMVVLVQEKENDYYCSLMKSIVDYILMDPMERKRLFIESIPRLFPQRVIRAPVPWHSVYRSAKKWNEEHLHTVNPMMLRLKELWFAEFRDLRFVRTAEILAGKLPLQPQEFWDVIQKHCLEAHQTLLNKWIPTCAQLFTSRKEHWIHFAPKSNYDSSRNIEEYFASVASFMSLQLRELVIKSLEDLVSLFMIHKDGNDFKEPYQEMKFFIPQLIMIKLEVSEPIIVFNPSFDGCWELIRDSFLEIIKNSNGIPKLKYIPLKFSFTAAAADRQCVKAAEPGEPSMHAAATAMAELKGYNLLLGTVNAEEKLVSDFLIQTFKVFQKNQVGPCKYLNVYKKYVDLLDNTAEQNIAAFLKENHDIDDFVTKINAIKKRRNEIASMNITVPLAMFCLDATALNHDLCERAQNLKDHLIQFQVDVNRDTNTSICNQYSHIADKVSEVPANTKELVSLIEFLKKSSAVTVFKLRRQLRDASERLEFLMDYADLPYQIEDIFDNSRNLLLHKRDQAEMDLIKRCSEFELRLEGYHRELESFRKREVMTTEEMKHNVEKLNELSKNLNRAFAEFELINKEEELLEKEKSTYPLLQAMLKNKVPYEQLWSTAYEFSIKSEEWMNGPLFLLNAEQIAEEIGNMWRTTYKLIKTLSDVPAPRRLAENVKIKIDKFKQYIPILSISCNPGMKDRHWQQISEIVGYEIKPTETTCLSNMLEFGFGKFVEKLEPIGAAASKEYSLEKNLDRMKLDWVNVTFSFVKYRDTDTNILCAIDDIQMLLDDHVIKTQTMCGSPFIKPIEAECRKWEEKLIRIQDNLDAWLKCQATWLYLEPIFSSEDIIAQMPEEGRKFGIVDSYWKSLMSQAVKDNRILVAADQPRMAEKLQEANFLLEDIQKGLNDYLEKKRLFFPRFFFLSNDELLEILSETKDPLRVQPHLKKCFEGIAKLEFTDNLEIVGMISSEKETVPFIQKIYPANAKGMVEKWLQQVEQMMLASMREVIGLGIEAYVKVPRNHWVLQWPGQVVICVSSIFWTQEVSQALAENTLLDFLKKSNDQIAQIVQLVRGKLSSGARLTLGALTVIDVHARDVVAKLSEDRVSDLNDFQWISQLRYYWVAKDVQVQIITTEALYGYEYLGNSPRLVITPLTDRCYRTLMGALKLNLGGAPEGPAGTGKTETTKDLAKALAKQCVVFNCSDGLDYKAMGKFFKGLAQAGAWACFDEFNRIEVEVLSVVAQQILSIQQAIIRKLKTFIFEGTELSLNPTCAVFITMNPGYAGRAELPDNLKALFRTVAMMVPDYALIGEISLYSMGFLDSRSLAQKIVATYRLCSEQLSSQHHYDYGMRAVKSVLTAAGNLKLKYPEENESVLLLRALLDVNLAKFLAQDVPLFQGIISDLFPGVVLPKPDYEVFLKVLNDNIKKMKLQPVPWFIGKIIQIYEMMLVRHGYMIVGDPMGGKTSAYKVLAAALGDLHAANQMEEFAVEYKIINPKAITMGQLYGCFDQVSHEWMDGVLANAFREQASSLSDDRKWIIFDGPVDAIWIENMNTVLDDNKKLCLMSGEIIQMNSKMSLIFEPADLEQASPATVSRCGMIYMEPHQLGWKPLKDSYMDTLPSSLTKEHKELVNDMFMWLVQPCLEFGRLHCKFVVQTSPIHLAFSMMRLYSSLLDEIRAVEEEEMELGEGLSSQQIFLWLQGLFLFSLVWTVAGTINADSRKKFDVFFRNLIMGMDDNHPRPKSVKLTKNNIFPERGSIYDFYFIKQASGHWETWTQYITKEEEKVPAGAKVSELIIPTMETARQSFFLKTYLDHEIPMLFVGPTGTGKSAITNNFLLHLPKNTYLPNCINFSARTSANQTQDIIMSKLDRRRKGLFGPPIGKKAVVFVDDLNMPAKEVYGAQPPIELLRQWIDHGYWFDKKDTTRLDIVDMLLVTAMGPPGGGRNDITGRFTRHLNIISINAFEDDILTKIFSSIVDWHFGKGFDVMFLRYGKMLVQATKTIYRDAVENFLPTPSKSHYVFNLRDFSRVIQGVLLCPHTHLQDVEKCIRLWIHEVYRVFYDRLIDKEDRQVFFNMVKETTSNCFKQTIEKVLIHLSPTGKIVDDNIRSLFFGDYFKPESDQKIYDEITDLKQLTVVMEHYLEEFNNISKAPMSLVMFRFAIEHISRICRVLKQDKGHLLLVGIGGSGRQSAAKLSTFMNAYELYQIEITKNYAGNDWREDLKKIILQVGVATKSTVFLFADNQIKDESFVEDINMLLNTGDVPNIFPADEKADIVEKMQTAARTQGEKVEVTPLSMYNFFIERVINKISFSLAMSPIGDAFRNRLRMFPSLINCCTIDWFQSWPTDALELVANKFLEDVELDDNIRVEVVSMCKYFQESVKKLSLDYYNKLRRHNYVTPTSYLELILTFKTLLNSKRQEVAMMRNRYLTGLQKLDFAASQVAVMQRELTALQPQLILTSEETAKMMVKIEAETREADGKKLLVQADEKEANVAAAIAQGIKNECEGDLAEAMPALEAALAALDTLNPADISLVKSMQNPPGPVKLVMESICIMKGMKPERKPDPSGSGKMIEDYWGVSKKILGDLKFLESLKTYDKDNIPPLTMKRIRERFINHPEFQPAVIKNVSSACEGLCKWVRAMEVYDRVAKVVAPKRERLREAEGKLAAQMQKLNQKRAELKLVVDRLQALNDDFEEMNTKKKDLEENIEICSQKLVRAEKLISGLGGEKDRWTEAARQLGIRYTNLTGDVLLSSGTVAYLGAFTVDYRVQCQNQWLAECKDKVIPGFSDFSLSHTLGDPIKIRAWQIAGLPVDSFSIDNGIIVSNSRRWALMIDPHGQANKWIKNMEKANKLAVIKFSDSNYMRMLENALQLGTPVLIENIGEELDASIEPILLKATFKQQGVEYMRLGENIIEYSRDFKLYITTRLRNPHYLPEVAVKVCLLNFMITPLGLQDQLLGIVAAKEKPELEEKKNQLIVESAKNKKHLKEIEDKILEVLSMSKGNILEDETAIKVLSSSKVLSEEISEKQKVASMTETQIDETRMGYKPVAVHSATIFFCISDLANIEPMYQYSLTWFINLYMHSLTHSTKSEELNLRIKYIIDHFTLSIYNNVCRSLFEKDKLLFSLLLTIGIMKQKKEITEEVWYFLLTGGIALDNPYPNPAPQWLSEKAWAEIVRASALPKLHGLMEHLEQNLGEWKLIYDSAWPHEEQLPGSWKFSQGLEKMVILRCLRPDKMVPAVREFIAEHMGKLYIEAPTFDLQGSYNDSSCCAPLIFVLSPSADPMAGLLKFADDLGMGGTRTQTISLGQGQGPIAAKMINNAIKDGTWVVLQNCHLAASWMPTLEKICEEVIVPESTNARFRLWLTSYPSEKFPVSILQNGIKMTNEPPKGLRANLLRSYLNDPISDPVFFQSCAKAVMWQKMLFGLCFFHAVVQERRNFGPLGWNIPYEFNESDLRISMWQIQMFLNDYKEVPFDALTYLTGECNYGGRVTDDKDRRLLLSLLSMFYCKEIEEDYYSLAPGDTYYIPPHGSYQSYIDYLRNLPITAHPEVFGLHENADITKDNQETNQLFEGVLLTLPRQSGGSGKSPQEVVEELAQDILSKLPRDFDLEEVMKLYPVVYEESMNTVLRQELIRFNRLTKVVRRSLINLGRAIKGQVLMSSELEEVFNSMLVGKVPAMWAAKSYPSLKPLGGYVADLLARLTFFQEWIDKGPPVVFWISGFYFTQSFLTGVSQNYARKYTIPIDHIGFEFEVTPQETVMENNPEDGAYIKGLFLEGARWDRKTMQIGESLPKILYDPLPIIWLKPGESAMFLHQDIYVCPVYKTSARRGTLSTTGHSTNYVLSIELPTDMPQKHWINRGVASLCQLDN"},{"id":"SEQ_07470","a":"Q96JQ0","g":"DCHS1","d":"Protocadherin-16","L":3298,"m":[{"c":"(x){6,16}[PE]xxx[PA]PG[TS]xψxxψxAxD[PA]DxGxNGxφ[TS]YxL(x){7,16}FxψDxx[TS]Gxψxψxx[PA]LDRE(x){2,5}φxLxψxAxDxG[SA]PPxxATxψxψxψxxDxND[NH]APxF","u":"98-120","sp":"tandem","x":"structured_like","cf":"high","why":"27 head-to-tail structured repeats (98-120 aa) span residues 46-2925, anchored by conserved PG[TS], AxD[PA]DxGxNGxφ[TS]YxL, FxψDxx[TS]G, [PA]LDRE, AxDxG[SA]PP, and C-terminal DxND[NH]APxF motifs alternating with aliphatic beta-strand cores. A separate scan of the N-terminal leader and C-terminal disordered/mixed tail (residues 2960-3298) found no additional multi-position repeat family (>=5 aa, >=3 copies).","i":[[46,143,"SLDLQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQRDRYRFTAVTPDGATVEVTVRVADINDHAPAF"],[144,255,"PQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAF"],[256,362,"NQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSM"],[363,472,"TVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAF"],[473,578,"DRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQF"],[579,685,"QRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNPPQF"],[686,790,"YPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIF"],[791,894,"EQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAF"],[895,1000,"PAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRF"],[1001,1105,"NSPTYRVDLPSGTTAGTQVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRL"],[1106,1211,"SEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTF"],[1212,1322,"LQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPP"],[1323,1436,"DLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAF"],[1437,1546,"ARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF"],[1547,1649,"ASPSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTF"],[1650,1751,"QQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTF"],[1752,1855,"GSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAF"],[1856,1960,"PVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTF"],[1961,2069,"PTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFP"],[2070,2171,"RASSEATIRENAPPGTPIVSPRAVHAGGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRF"],[2172,2277,"LRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTI"],[2278,2376,"PQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDVNDNAPAF"],[2377,2482,"SQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSF"],[2483,2602,"TLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVF"],[2603,2706,"TRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVNDHGPAF"],[2707,2813,"PLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVF"],[2814,2925,"LAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYLRVDSRAPGSGTATSGGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTVDITHT"]]}],"s":"MQKELGIVPSCPGMKSPRPHLLLPLLLLLLLLLGAGVPGAWGQAGSLDLQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQRDRYRFTAVTPDGATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYLRVDSRAPGSGTATSGGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTVDITHTALGLAPDLNLLLVGAVAASLGVVVVLALAALVLGLVRARSRKAEAAPGPMSQAAPLASDSLQKLGREPPSPPPSEHLYHQTLPSYGGPGAGGPYPRGGSLDPSHSSGRGSAEAAEDDEIRMINEFPRVASVASSLAARGPDSGIQQDADGLSDTSCEPPAPDTWYKGRKAGLLLPGAGATLYREEGPPATATAFLGGCGLSPAPTGDYGFPADGKPCVAGALTAIVAGEEELRGSYNWDYLLSWCPQFQPLASVFTEIARLKDEARPCPPAPRIDPPPLITAVAHPGAKSVPPKPANTAAARAIFPPASHRSPISHEGSLSSAAMSPSFSPSLSPLAARSPVVSPFGVAQGPSASALSAESGLEPPDDTELHI"},{"id":"SEQ_07480","a":"Q71F78","g":"LCA10","d":"Putative lung carcinoma-associated protein 10","L":164,"m":[{"c":"CPxxD","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"All four cysteines in this 164-aa proline/glycine-rich disordered sequence form an invariant C-P-x-x-D motif, occurring once as an exact head-to-tail tandem pair (CPVHDCPSWD) near the N-terminus and twice as dispersed copies centrally.","i":[[4,8,"CPVHD"],[9,13,"CPSWD"],[72,76,"CPEPD"],[100,104,"CPAQD"]]}],"s":"MSSCPVHDCPSWDPERLEPVETGSRGALRLRGGAPGSAAGFRASIWGPAGYPSPVGLGHPASLPRPAYSPRCPEPDARHGWGSGSNAGYRGPDRAGRTPCPAQDREGRSSSPVPPPRLKAMTSQARKQNGGALIDTVDWTREAPDSDPVMSMQKTQKPQTTVGQ"},{"id":"SEQ_07485","a":"Q8N4P6","g":"LRRC71","d":"Leucine-rich repeat-containing protein 71","L":559,"m":[{"c":"[LI]xx[LV][SN]LxxNxφ(x){4,6}xxxxxx[LV]","u":"22-24","sp":"dispersed","x":"structured_like","cf":"high","why":"Six leucine-rich repeat units featuring a tightly conserved 11-residue N-terminal beta-strand/turn core ([LI]xx[LV][SN]LxxNxφ with invariant L6 and N9), a 4-6 residue loop, and an amphipathic helical segment ending in [LV], split into a four-copy N-terminal cluster and two C-terminal copies separated by a long disordered linker.","i":[[197,218,"LRKVSLEGNPLPEQSYHKLMAL"],[222,244,"IAHLSLRNNNIDDRGAQLLGQAL"],[254,276,"LVSLNLGFNHIGDEGAGYIADGL"],[282,304,"LLWLSLAHNRIQDKGALKLAEVL"],[474,496,"LLHLNLIRNRITEVGLEGFLATV"],[515,538,"LLWLSLAKNCFAPQCPAYAIIQEL"]]}],"s":"MSSEQSAPGASPRAPRPGTQKSSGAVTKKGERAAKEKPATVLPPVGEEEPKSPEEYQCSGVLETDFAELCTRWGYTDFPKVVNRPRPHPPFVPSASLSEKATLDDPRLSGSCSLNSLESKYVFFRPTIQVELEQEDSKSVKEIYIRGWKVEERILGVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLRAFELTHTEVVERRRLLLEKGTQERSRSPSSSRHGDSKTDREKSQMVGISNSALVDKTDKTQTMKTPKGLGKKKEKSWELAKKEEKLGSGQSPTQGTPKKEDATKAGKGKVTIPEQKPSRAKGIKIGSREKRSILLESELVVEATEVVNPLLEPVEHRDGKVFMPGNKVLLHLNLIRNRITEVGLEGFLATVQYQMQFSKAKSASKGPVGLLWLSLAKNCFAPQCPAYAIIQELMLPRDPIKAKLREDEAMAFFP"},{"id":"SEQ_07504","a":"Q02383","g":"SEMG2","d":"Semenogelin-2","L":582,"m":[{"c":"[GA]x[KQ]xxx[KQ]x[VG][SP][KQ]x[SI]φxxQxExxψx[GN]KoQx[QE][VT]x[IN]xxQx[QK]xx[GY][HQR][KN]xxxx[SR]xx[SH][SA]xxx[EQ]xxL[NHS]x","u":60,"sp":"tandem","x":"disordered_like","cf":"high","why":"Six head-to-tail 60-aa tandem repeats in a polar/charged disordered-like region, anchored by invariant Q17, E19, aliphatic ψ22, K25, Q27, Q35, and L58 alongside highly conserved SKGSISI, QDQEHG, and SSSTEERxL submotifs (with more divergent N- and C-terminal remnant copies flanking the main array).","i":[[181,240,"AQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHP"],[241,300,"AHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHH"],[301,360,"GEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNC"],[361,420,"GEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNS"],[421,480,"GEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNY"],[481,540,"GGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSH"]]}],"s":"MKSIILFVLSLLLILEKQAAVMGQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSHEQKGRYKQESSESHNIVITEHEVAQDDHLTQQYNEDRNPIST"},{"id":"SEQ_07505","a":"Q9UMZ2","g":"SYNRG","d":"Synergin gamma","L":1314,"m":[{"c":"D[DSG]Fx-F","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Seven dispersed copies of an acidic-aromatic short linear motif within the central disordered region (aa 453-1027), defined by invariant D1, F3, and F6 anchors, a conserved acidic [DE]5 position, and an adjacent N-terminal DD dipeptide across all instances.","i":[[456,461,"DDFQDF"],[472,477,"DSFSDF"],[568,573,"DGFTDF"],[668,673,"DDFGEF"],[689,694,"DDFADF"],[774,779,"DDFADF"],[1022,1027,"DDFGEF"]]},{"c":"[DT]KYx[AV][FL]+","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four non-overlapping dispersed 7-aa motifs in the same central disordered region (aa 512-749) featuring invariant K2 and Y3 anchors flanked by [DT]1, small aliphatic [AV]5, bulky hydrophobic [FL]6, and basic [KR]7 (with degenerate DLKYAAF and DKYKDL variants further C-terminal).","i":[[512,518,"DKYAVFK"],[537,543,"DKYSAFR"],[710,716,"DKYDALK"],[743,749,"TKYDVFR"]]}],"s":"MALRPGAGSGGGGAAGAGAGSAGGGGFMFPVAGGIRPPQAGLMPMQQQGFPMVSVMQPNMQGIMGMNYSSQMSQGPIAMQAGIPMGPMPAAGMPYLGQAPFLGMRPPGPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKSRDDALEAIKGNLDGFSRDAKMHPTPASHPKKPGPSLEEKFLVSCDISTSGQEQIKLNTSEVGHKALGPGSSKKYPSLMASNGVAVDGCVSGTTTAEAENTSDQNLSIEESGVGVFPSQDPAQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANRTTPGKLTKEELYTVLAMIAVTQRGVPAMSPDALNQFPAAPIPTLSGFSMTLPTPVSQPTVIPSGPAGSMPLSLGQPVMGINLVGPVGGAAAQASSGFIPTYPANQVVKPEEDDFQDFQDASKSGSLDDSFSDFQELPASSKTSNSQHGNSAPSLLMPLPGTKALPSMDKYAVFKGIAADKSSENTVPPGDPGDKYSAFRELEQTAENKPLGESFAEFRSAGTDDGFTDFKTADSVSPLEPPTKDKTFPPSFPSGTIQQKQQTQVKNPLNLADLDMFSSVNCSSEKPLSFSAVFSTSKSVSTPQSTGSAATMTALAATKTSSLADDFGEFSLFGEYSGLAPVGEQDDFADFMAFSNSSISSEQKPDDKYDALKEEASPVPLTSNVGSTVKGGQNSTAASTKYDVFRQLSLEGSGLGVEDLKDNTPSGKSDDDFADFHSSKFSSINSDKSLGEKAVAFRHTKEDSASVKSLDLPSIGGSSVGKEDSEDALSVQFDMKLADVGGDLKHVMSDSSLDLPTVSGQHPPAADIEDLKYAAFGSYSSNFAVSTLTSYDWSDRDDATQGRKLSPFVLSAGSGSPSATSILQKKETSFGSSENITMTSLSKVTTFVSEDALPETTFPALASFKDTIPQTSEQKEYENRDYKDFTKQDLPTAERSQEATCPSPASSGASQETPNECSDDFGEFQSEKPKISKFDFLVATSQSKMKSSEEMIKSELATFDLSVQGSHKRSLSLGDKEISRSSPSPALEQPFRDRSNTLNEKPALPVIRDKYKDLTGEVEENERYAYEWQRCLGSALNVIKKANDTLNGISSSSVCTEVIQSAQGMEYLLGVVEVYRVTKRVELGIKATAVCSEKLQQLLKDIDKVWNNLIGFMSLATLTPDENSLDFSSCMLRPGIKNAQELACGVCLLNVDSRSRKEEKPAEEHPKKAFNSETDSFKLAYGGHQYHASCANFWINCVEPKPPGLVLPDLL"},{"id":"SEQ_07523","a":"Q96K30","g":"RITA1","d":"RBPJ-interacting and tubulin-associated protein 1","L":269,"m":[{"c":"Rx+xxYR(x){5,6}SYxDE[ST]LFGS","u":"22-23","sp":"dispersed","x":"mixed","cf":"high","why":"Strongly conserved 2-copy 22-23 aa internal duplication anchored by an N-terminal Rx+xxYR motif and a highly conserved C-terminal SYxDE[ST]LFGS block separated by a 5-6 residue variable linker. The two copies are separated by a 53-residue proline/serine-enriched linker.","i":[[20,41,"RCRGGYRVKARTSYVDETLFGS"],[95,117,"RKKNKYRPISHTPSYCDESLFGS"]]}],"s":"MKTPVELAVSGMQTLGLQHRCRGGYRVKARTSYVDETLFGSPAGTRPTPPDFDPPWVEKANRTRGVGKEASKALGAKGSCETTPSRGSTPTLTPRKKNKYRPISHTPSYCDESLFGSRSEGASFGAPRMAKGDAAKLRALLWTPPPTPRGSHSPRPREAPLRAIHPAGPSKTEPGPAADSQKLSMGGLHSSRPLKRGLSHSLTHLNVPSTGHPATSAPHTNGPQDLRPSTSGVTFRSPLVTSRARSVSISVPSTPRRGGATQKPKPPWK"},{"id":"SEQ_07527","a":"Q13127","g":"REST","d":"RE1-silencing transcription factor","L":1097,"m":[{"c":"[KRG]xφxCxxCx[YR]xxxxxxxφxxHφ(x){2,3}Hxxx","u":"28-29","sp":"dispersed","x":"structured_like","cf":"high","why":"Nine 28-29 aa structured repeats defined by invariant CxxC and HxxxH/HxxxxH coordination pairs alongside three conserved hydrophobic core positions (φ at positions 3, 18, and 22), organized as a central 6-copy tandem array flanked by two N-terminal copies and one C-terminal copy.","i":[[157,184,"KPFRCKPCQYEAESEEQFVHHIRVHSAK"],[214,241,"GPIRCDRCGYNTNRYDHYTAHLKHHTRA"],[246,273,"RVYKCIICTYTTVSEYHWRKHLRNHFPR"],[274,301,"KVYTCGKCNYFSDRKNNYVQHVRTHTGE"],[302,329,"RPYKCELCPYSSSQKTHLTRHMRTHSGE"],[330,358,"KPFKCDQCSYVASNQHEVTRHARQVHNGP"],[359,386,"KPLNCPHCDYKTADRSNFKKHVELHVNP"],[387,415,"RQFNCPVCDYAASKKCNLQYHFKSKHPTC"],[1058,1085,"GDFVCIFCDRSFRKGKDYSKHLNRHLVN"]]},{"c":"[MI]xx[AV]Qx[EGV]x[AV][QKH]x[ERG][LPS]xP","u":15,"sp":"tandem","x":"disordered_like","cf":"high","why":"Ten 15-aa repeats in the central proline/glutamine-enriched disordered region anchored by N-terminal M/I, invariant Q5 and P15, and two conserved [AV] positions (4 and 9), packed predominantly head-to-tail (0-1 aa gaps across the C-terminal eight copies and 5-6 aa linkers between the first three).","i":[[634,648,"MEHAQMEGAQIRPAP"],[654,668,"MEVVQEGPAQKELLP"],[675,689,"MVGAQIVLAHMELPP"],[691,705,"METAQTEVAQMGPAP"],[706,720,"MEPAQMEVAQVESAP"],[721,735,"MQVVQKEPVQMELSP"],[737,751,"MEVVQKEPVQIELSP"],[753,767,"MEVVQKEPVKIELSP"],[769,783,"IEVVQKEPVQMELSP"],[785,799,"MGVVQKEPAQREPPP"]]}],"s":"MATQVMGQSSGGGGLFTSSGNIGMALPNDMYDLHDLSKAELAAPQLIMLANVALTGEVNGSCCDYLVGEERQMAELMPVGDNNFSDSEEGEGLEESADIKGEPHGLENMELRSLELSVVEPQPVFEASGAPDIYSSNKDLPPETPGAEDKGKSSKTKPFRCKPCQYEAESEEQFVHHIRVHSAKKFFVEESAEKQAKARESGSSTAEEGDFSKGPIRCDRCGYNTNRYDHYTAHLKHHTRAGDNERVYKCIICTYTTVSEYHWRKHLRNHFPRKVYTCGKCNYFSDRKNNYVQHVRTHTGERPYKCELCPYSSSQKTHLTRHMRTHSGEKPFKCDQCSYVASNQHEVTRHARQVHNGPKPLNCPHCDYKTADRSNFKKHVELHVNPRQFNCPVCDYAASKKCNLQYHFKSKHPTCPNKTMDVSKVKLKKTKKREADLPDNITNEKTEIEQTKIKGDVAGKKNEKSVKAEKRDVSKEKKPSNNVSVIQVTTRTRKSVTEVKEMDVHTGSNSEKFSKTKKSKRKLEVDSHSLHGPVNDEESSTKKKKKVESKSKNNSQEVPKGDSKVEENKKQNTCMKKSTKKKTLKNKSSKKSSKPPQKEPVEKGSAQMDPPQMGPAPTEAVQKGPVQVEPPPPMEHAQMEGAQIRPAPDEPVQMEVVQEGPAQKELLPPVEPAQMVGAQIVLAHMELPPPMETAQTEVAQMGPAPMEPAQMEVAQVESAPMQVVQKEPVQMELSPPMEVVQKEPVQIELSPPMEVVQKEPVKIELSPPIEVVQKEPVQMELSPPMGVVQKEPAQREPPPPREPPLHMEPISKKPPLRKDKKEKSNMQSERARKEQVLIEVGLVPVKDSWLLKESVSTEDLSPPSPPLPKENLREEASGDQKLLNTGEGNKEAPLQKVGAEEADESLPGLAANINESTHISSSGQNLNTPEGETLNGKHQTDSIVCEMKMDTDQNTRENLTGINSTVEEPVSPMLPPSAVEEREAVSKTALASPPATMAANESQEIDEDEGIHSHEGSDLSDNMSEGSDDSGLHGARPVPQESSRKNAKEALAVKAAKGDFVCIFCDRSFRKGKDYSKHLNRHLVNVYYLEEAAQGQE"},{"id":"SEQ_07536","a":"Q9UJY5","g":"GGA1","d":"ADP-ribosylation factor-binding protein GGA1","L":639,"m":[{"c":"[SA][LG]LD[DL]xx[LM]","u":8,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 8-aa acidic-leucine motifs embedded in the central P/S/T/Q-rich disordered region (residues 318-425), sharing an invariant LD core, constrained [SA][LG] N-terminal and [DL] post-core positions, and a C-terminal aliphatic [LM] residue.","i":[[318,325,"ALLDLSGL"],[355,362,"SLLDDELM"],[418,425,"SGLDDLDL"]]}],"s":"MEPAMEPETLEARINRATNPLNKELDWASINGFCEQLNEDFEGPPLATRLLAHKIQSPQEWEAIQALTVLETCMKSCGKRFHDEVGKFRFLNELIKVVSPKYLGSRTSEKVKNKILELLYSWTVGLPEEVKIAEAYQMLKKQGIVKSDPKLPDDTTFPLPPPRPKNVIFEDEEKSKMLARLLKSSHPEDLRAANKLIKEMVQEDQKRMEKISKRVNAIEEVNNNVKLLTEMVMSHSQGGAAAGSSEDLMKELYQRCERMRPTLFRLASDTEDNDEALAEILQANDNLTQVINLYKQLVRGEEVNGDATAGSIPGSTSALLDLSGLDLPPAGTTYPAMPTRPGEQASPEQPSASVSLLDDELMSLGLSDPTPPSGPSLDGTGWNSFQSSDATEPPAPALAQAPSMESRPPAQTSLPASSGLDDLDLLGKTLLQQSLPPESQQVRWEKQQPTPRLTLRDLQNKSSSCSSPSSSATSLLHTVSPEPPRPPQQPVPTELSLASITVPLESIKPSNILPVTVYDQHGFRILFHFARDPLPGRSDVLVVVVSMLSTAPQPIRNIVFQSAVPKVMKVKLQPPSGTELPAFNPIVHPSAITQVLLLANPQKEKVRLRYKLTFTMGDQTYNEMGDVDQFPPPETWGSL"},{"id":"SEQ_07565","a":"A6NEF3","g":"GOLGA6L4","d":"Golgin subfamily A member 6-like protein 4","L":574,"m":[{"c":"ERLLEEVEKLLEQER[RQ]QEEQERLLER","u":26,"sp":"tandem","x":"mixed","cf":"high","why":"Three contiguous 26-residue tandem duplications with 25 of 26 positions strictly invariant (varying only at R/Q in position 16), combining conserved di-leucine/valine hydrophobic anchors with E/R/Q/K-rich helical segments.","i":[[323,348,"ERLLEEVEKLLEQERRQEEQERLLER"],[349,374,"ERLLEEVEKLLEQERQQEEQERLLER"],[375,400,"ERLLEEVEKLLEQERRQEEQERLLER"]]},{"c":"E[ED]RL[RCH]E[QH]","u":7,"sp":"tandem","x":"mixed","cf":"high","why":"Seventeen head-to-tail 7-residue repeats with invariant E-x-R-L-x-E architecture, nearly fixed E and Q at positions 2 and 7, and a specific R/C/H choice at position 5 that distinguishes this duplicated array from a generic charged rod.","i":[[198,204,"EERLREQ"],[205,211,"EERLREQ"],[212,218,"EERLREQ"],[219,225,"EDRLHEQ"],[226,232,"EERLREQ"],[233,239,"EERLCEQ"],[240,246,"EERLREH"],[247,253,"EERLCEQ"],[254,260,"EERLCEQ"],[261,267,"EERLREQ"],[268,274,"EERLHEQ"],[275,281,"EERLREQ"],[282,288,"EERLCEQ"],[289,295,"EERLREQ"],[296,302,"EERLCEQ"],[303,309,"EERLREQ"],[310,316,"EERLCEQ"]]}],"s":"MWPQPRFPPHPAMSEKTQQGKLAAAKKKLKAYWQRKSPGIPAGANRKKKINGSSPDTATSGGYHSPGDSATGIYGEGRASSTTLEDLESQYQELAVALDSSSAIISQLTENINSLVRTSKEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLREQEERLREQEDRLHEQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLEEVEKLLEQERQQEEQERLLERERLLEEVEKLLEQERRQEEQERLLERERLLDEVEELLDEVEELLEQERLRQQDERLWQQETLQELERLRELERLRELERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKELKKSGGAEEPRGSESAAAARPVAGAPVPQGAWMCGQAGWTPQEHPGLSGEAVGTGEAAGGAGEAACHSFRAAENRELNITII"},{"id":"SEQ_07566","a":"Q5SSJ5","g":"HP1BP3","d":"Heterochromatin protein 1-binding protein 3","L":553,"m":[{"c":"ψ-xφψxxAφx[AR]xx[QE][PK][KS]x[AC]Sxxφψ+KYψxxx[YH]Pxxxxxx[RQ]xxLLKx[AT]L[KQ]+xxx[RN]Gxψ[EK]QψxGKGφSG[ST]F[QV]ψ","u":70,"sp":"dispersed","x":"structured_like","cf":"high","why":"Three ungapped 70-residue globular domain repeats separated by 28-aa and 13-aa linkers, anchored by strictly conserved A, S, +KYψ, [YH]P, LLKx[AT]L[KQ]+, Gxψ[EK]Qψ, and C-terminal GKGφSG[ST]F[QV]ψ signature motifs.","i":[[161,230,"MDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLELERRGYLLKQALKRELNRGVIKQVKGKGASGSFVV"],[259,328,"LEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQL"],[342,411,"MEYAILSAIAAMNEPKTCSTTALKKYVLENHPGTNSNYQMHLLKKTLQKCEKNGWMEQISGKGFSGTFQL"]]}],"s":"MATDTSQGELVHPKALPLIVGAQLIHADKLGEKVEDSTMPIRRTVNSTRETPPKSKLAEGEEEKPEPDISSEESVSTVEEQENETPPATSSEAEQPKGEPENEEKEENKSSEETKKDEKDQSKEKEKKVKKTIPSWATLSASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLELERRGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSRKTPQKSRNRKNRSSAVDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGTNSNYQMHLLKKTLQKCEKNGWMEQISGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSEDEEPPPKRRLQKKTPAKSPGKAASVKQRGSKPAPKVSAAQRGKARPLPKKAPPKAKTPAKKTRPSSTVIKKPSGGSSKKPATSARKEVKLPGKGKSTMKKSFRVKK"},{"id":"SEQ_07568","a":"Q5VYP0","g":"SPATA31A3","d":"Spermatogenesis-associated protein 31A3","L":1347,"m":[{"c":"V[AS]xPxxx[NQ]xxxxxxLPE[TN](x){1,2}PxxPxLRRQLE","u":"30-31","sp":"dispersed","x":"disordered_like","cf":"high","why":"Two-copy 30-31 aa internal duplication separated by a 17-residue linker, strongly anchored by an N-terminal V[AS]xP motif, a conserved in-phase LPE[TN] turn after a 10-aa spacer, and a highly conserved C-terminal PxxPxLRRQLE segment (13 identical positions overall).","i":[[523,553,"VACPASQNKVQALSLPETQHPEWPLLRRQLE"],[571,600,"VSTPNLPQESLTSILPENFPVSPELRRQLE"]]}],"s":"MENLPFPLKLLSASSLNAPSSTPWVLDIFLTLVFALGFFFLLLPYLSYFRCDDPPSPSPGKRKCPVGRRRRPRGRMKNHSLRAGRECRRGLEETSDLLSQLQSLLGPHLDKGDFGQLSGPDPPGEVGERAPDGASQSSHEPMEDAAPILSLLASPDPQAKHPQDLASTPSPGPMTTSVSSLSASQPPEPSLPLEHPSPEPPALFPHPPHTPDPLACSLPPPKGFTAPPLRDSTLITPSHCDSVALPLGTVPQSLSPHEDLVASVPAISGLGGSNSHVSASSRWQETARTSCAFNSSVQQDHLSRHPPETCQMEAGSLFLLSSDGQNVVGIQVTETAKVNIWEEKENVGSFTNRMTPEKHLNSLRNLAKSLDAEQDTTNPKPFWNMGENSKQLPGPQKLSDPRLWQESFWKNYSQLFWGLPSLHSESLVANAWVTDRSYTLQSPPFLFNEMSNVCPIQRETTMSPLLFQAQPLSHLGPECQPFISSTPQFRPTPMAQAEAQAHLQSSFPVLSPAFPSLIQNTGVACPASQNKVQALSLPETQHPEWPLLRRQLEGRLALPSRVQKSQDVFSVSTPNLPQESLTSILPENFPVSPELRRQLEQHIKKWIIQHWGNLGRIQESLDLMQLQDESPGTSQAKGKPSPWQSSMSTGESSKEAQKVKFQLERDPCPHLGQILGETPQNLSRDMKSFPRKVLGVTSEELERNLRKPLRSDSGSDLLRCTERTHIENILKAHMGRNLGQTNEGLIPVRVRRSWLAVNQALPVSNTHVKTSNLAAPKSGKACVNTAQVLSFLEPCTQQGLGAHIVRFWAKHRWGLPLRVLKPIQCFKLEKVSSLSLTQLAGPSSATCESGAGSEVEVDMFLRKPPMASLRKQVLTKASDHMPESLLASSPAWKQFQRAPRGIPSWNDHEPLKPPPAGQEGRWPSKPLTYSLTGSTQQSRSLGAQSSKAGETREAVPQCRVPLETCMLANLQATSEDVHGFEAPGTSKSSLHPRVSVSQDPRKLCLMEEVVSEFEPGMATKSETQPQVCAAVVLLPDGQASVVPHASENLVSQVPQGHLQSMPTGNMRASQELHDLMAARRSKLVHEEPRKPNCQGSCKSQRPMFPPIHKSEKFRKPNLEKHEERLEGLRTPQLTPVRKTEDTHQDEGVQLLPSKKQPPSVSPFGENIKQIFQWIFSKKKSKPAPVTAESQKTVKNRSCVYSSSAEAQGLMTAVGQMLDEKMSLCHARHASKVNQHKQKFQAPVCGFPCNHRHLFYSEHGRILSYAASSQQATLKSQGCPNRDRQIRNQQPLKSVRCNNEQWGLRHPQILHPKKAVSPVSPPQHWPKTSGASSHHHHCPRHCLLWEGI"},{"id":"SEQ_07589","a":"Q9BRR8","g":"GPATCH1","d":"G patch domain-containing protein 1","L":931,"m":[{"c":"ΩxP[DK][DN][VN][TV]","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three-copy local tandem repeat array in a disordered acidic/proline-rich segment anchored by an N-terminal aromatic residue (Y/F) and fixed Pro at position 3 followed by conserved charged/polar/valyl-threonyl positions, with minor 1-residue indel variation between head-to-tail copies 1-2 and copy 3 after a 3-aa linker.","i":[[210,216,"YLPDNVT"],[217,223,"FAPKDVT"],[227,233,"FTPKDNV"]]}],"s":"MAARDSDSEEDLVSYGTGLEPLEEGERPKKPIPLQDQTVRDEKGRYKRFHGAFSGGFSAGYFNTVGSKEGWTPSTFVSSRQNRADKSVLGPEDFMDEEDLSEFGIAPKAIVTTDDFASKTKDRIREKARQLAAATAPIPGATLLDDLITPAKLSVGFELLRKMGWKEGQGVGPRVKRRPRRQKPDPGVKIYGCALPPGSSEGSEGEDDDYLPDNVTFAPKDVTPVDFTPKDNVHGLAYKGLDPHQALFGTSGEHFNLFSGGSERAGDLGEIGLNKGRKLGISGQAFGVGALEEEDDDIYATETLSKYDTVLKDEEPGDGLYGWTAPRQYKNQKESEKDLRYVGKILDGFSLASKPLSSKKIYPPPELPRDYRPVHYFRPMVAATSENSHLLQVLSESAGKATPDPGTHSKHQLNASKRAELLGETPIQGSATSVLEFLSQKDKERIKEMKQATDLKAAQLKARSLAQNAQSSRAQLSPAAAAGHCSWNMALGGGTATLKASNFKPFAKDPEKQKRYDEFLVHMKQGQKDALERCLDPSMTEWERGRERDEFARAALLYASSHSTLSSRFTHAKEEDDSDQVEVPRDQENDVGDKQSAVKMKMFGKLTRDTFEWHPDKLLCKRFNVPDPYPDSTLVGLPRVKRDKYSVFNFLTLPETASLPTTQASSEKVSQHRGPDKSRKPSRWDTSKHEKKEDSISEFLSLARSKAEPPKQQSSPLVNKEEEHAPELSANQTVNKDVDAQAEGEGSRPSMDLFRAIFASSSDEKSSSSEDEQGDSEDDQAGSGEANFQSSQDTDLGETSSVAHALVPAPQEPPPSFPIQKMQIDEREEFGPRLPPVFCPNARQTLEVPQKEKHKKNKDKHKAKKEHRRKKEKKKKHRKHKHKGKQKNKKPEKSSSSESSDSSDSQSDEETADVSPQELLRRLKSLPLRRQ"},{"id":"SEQ_07591","a":"Q7Z7M9","g":"GALNT5","d":"Polypeptide N-acetylgalactosaminyltransferase 5","L":940,"m":[{"c":"Cψ(x){6,8}ψxψxxCD(x){6,10}[KT]W","u":"25-27","sp":"dispersed","x":"structured_like","cf":"high","why":"Three C-terminal cysteine-rich subdomain repeats (25-27 aa, separated by 10 and 24 aa linkers) anchored by an invariant N-terminal Cψ pair, a conserved aliphatic-flanked CD motif (ψxψxxCD), and a C-terminal [KT]W aromatic core.","i":[[822,848,"CISIENTTVILEDCDGSKELQQFNYTW"],[858,882,"CIAPIPDKGAVRLHPCDNRNKGLKW"],[908,932,"CLEGNFSQKILKVAACDPVKPYQKW"]]}],"s":"MNRIRKFFRGSGRVLAFIFVASVIWLLFDMAALRLSFSEINTRVIKEDIVRRERIGFRVQPDQGKIFYSSIKEMKPPLRGHGKGAWGKENVRKTEESVLKVEVDLDQTQRERKMQNALGRGKVVPLWHPAHLQTLPVTPNKQKTDGRGTKPEASSHQGTPKQTTAQGAPKTSFIAAKGTQVVKISVHMGRVSLKQEPRKSHSPSSDTSKLAAERDLNVTISLSTDRPKQRSQAVANERAHPASTAVPKSGEAMALNKTKTQSKEVNANKHKANTSLPFPKFTVNSNRLRKQSINETPLGSLSKDDGARGAHGKKLNFSESHLVIITKEEEQKADPKEVSNSKTKTIFPKVLGKSQSKHISRNRSEMSSSSLAPHRVPLSQTNHALTGGLEPAKINITAKAPSTEYNQSHIKALLPEDSGTHQVLRIDVTLSPRDPKAPGQFGRPVVVPHGKEKEAERRWKEGNFNVYLSDLIPVDRAIEDTRPAGCAEQLVHNNLPTTSVIMCFVDEVWSTLLRSVHSVINRSPPHLIKEILLVDDFSTKDYLKDNLDKYMSQFPKVRILRLKERHGLIRARLAGAQNATGDVLTFLDSHVECNVGWLEPLLERVYLSRKKVACPVIEVINDKDMSYMTVDNFQRGIFVWPMNFGWRTIPPDVIAKNRIKETDTIRCPVMAGGLFSIDKSYFFELGTYDPGLDVWGGENMELSFKVWMCGGEIEIIPCSRVGHIFRNDNPYSFPKDRMKTVERNLVRVAEVWLDEYKELFYGHGDHLIDQGLDVGNLTQQRELRKKLKCKSFKWYLENVFPDLRAPIVRASGVLINVALGKCISIENTTVILEDCDGSKELQQFNYTWLRLIKCGEWCIAPIPDKGAVRLHPCDNRNKGLKWLHKSTSVFHPELVNHIVFENNQQLLCLEGNFSQKILKVAACDPVKPYQKWKFEKYYEA"},{"id":"SEQ_07592","a":"A8MZF0","g":"PRR33","d":"Proline-rich protein 33","L":331,"m":[{"c":"E[PQ]EVP[AT][PL]T","u":8,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three head-to-tail 8-aa tandem repeats (positions 217-240) in a proline/acidic disordered region, anchored by five invariant positions (E1, E3, V4, P5, T8) and constrained two-residue choices at the remaining positions.","i":[[217,224,"EPEVPTPT"],[225,232,"EQEVPAPT"],[233,240,"EQEVPALT"]]}],"s":"MGPQVVASAPEPTRPPSGFVPVSGGGGTHVTQVHIQLAPSPHNGTPEPPRTAPEVGSNSQDGDATPSPPRAQPLVPVAHIRPLPTTVQAASPLPEEPPVPRPPPGFQASVPREASARVVVPIAPTCRSLESSPHSLVPMGPGREHLEEPPMAGPAAEAERVSSPAWASSPTPPSGPHPCPVPKVAPKPRLSGWTWLKKQLLEEAPEPPCPEPRQSLEPEVPTPTEQEVPAPTEQEVPALTAPRAPASRTSRMWDAVLYRMSVAEAQGRLAGPSGGEHTPASLTRLPFLYRPRFNARKLQEATRPPPTVRSILELSPQPKNFNRTATGWRLQ"},{"id":"SEQ_07612","a":"Q13635","g":"PTCH1","d":"Protein patched homolog 1","L":1447,"m":[{"c":"AGψψψψφL(x){10,12}LIGI(x){7,8}Vψxφφ[AS]ψG[VI]GV-xxφxψAxAF(x){3,4}GxxxR","u":"59-61","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of a ~60-aa multi-transmembrane core present in both halves of the protein, anchored by N-terminal AGψψψψφL, central LIGI, a highly conserved 21-aa G[VI]GV-xxφxψAxAF transmembrane signature, and a C-terminal GxxxR motif.","i":[[472,530,"AGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKR"],[1053,1113,"AGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNR"]]}],"s":"MASAGNAAEPQDRGGGGSGCIGAPGRPAGGGRRRRTGGLRRAAAPDRDYLHRPSYCDAAFALEQISKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN"},{"id":"SEQ_07620","a":"Q9Y2K7","g":"KDM2A","d":"Lysine-specific demethylase 2A","L":1162,"m":[{"c":"xxxφxψ[ASR]xx(x){15,16}","u":"24-25","sp":"tandem","x":"structured_like","cf":"high","why":"Eight C-terminal 24-25 aa structured repeats anchored by invariant hydrophobic/aliphatic core positions (φxψ at positions 4-6, predominantly L/I-D-L) followed by a conserved [ASR] residue, frequent Cys at position 9, and downstream aliphatic residues; units are arranged head-to-tail with two short internal linkers (14 aa and 6 aa).","i":[[930,953,"WTKIDLSRCKAIVPQALSGIIKRQ"],[954,978,"PVSLDLSWTNISKKQLTWLVNRLPG"],[979,1002,"LKDLLLAGCSWSAVSALSTSSCPL"],[1003,1026,"LRTLDLRWAVGIKDPQIRDLLTPP"],[1041,1065,"MTDFRLAGLDITDATLRLIIRHMPL"],[1066,1089,"LSRLDLSHCSHLTDQSSNLLTAVG"],[1096,1119,"LTELNMAGCNKLTDQTLIYLRRIA"],[1121,1144,"VTLIDLRGCKQITRKACEHFISDL"]]}],"s":"MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRHSPRVLVQHCPARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCKQITRKACEHFISDLSINSLYCLSDEKLIQKIS"},{"id":"SEQ_07628","a":"Q9P209","g":"CEP72","d":"Centrosomal protein of 72 kDa","L":647,"m":[{"c":"LxxLx[SE]L(x){6,9}[IL](x){8,11}","u":"22-26","sp":"tandem","x":"structured_like","cf":"high","why":"Four contiguous head-to-tail N-terminal 22-26 aa structured repeats defined by a strict LxxLx[SE]L N-terminal anchor motif and an internal [IL] hydrophobic core position separated by variable 6-9 aa and 8-11 aa segments.","i":[[27,52,"LAELQSLSIPGTYQEKITHLGHSLMS"],[53,74,"LTGLKSLDLSRNSLVSLEGIQY"],[75,96,"LTALESLNLYYNCISSLAEVFR"],[97,121,"LHALTELVDVDFRLNPVVKVEPDYR"]]}],"s":"MARAGPRLVLSEEAVRAKSGLGPHRDLAELQSLSIPGTYQEKITHLGHSLMSLTGLKSLDLSRNSLVSLEGIQYLTALESLNLYYNCISSLAEVFRLHALTELVDVDFRLNPVVKVEPDYRLFVVHLLPKLQQLDDRPVRASERKASRLHFASEDSLDSKESVPASLKEGRPHHPRAKCTEALAKQSLVMDADDEAVLNLIAECEWDLGRPPGSTSFSQKGREADSRGSQESRHLLSPQLVQYQCGDSGKQGRETRRSSCRGCCLEKMPWSQLCGELPPLYGAEPEASRAPRPHTYFTPHPDSMDTEDSASSQKLDLSGEMVPGPLPAPGKCRKRRMPVGRFQTFSDQEGLGCPERTHGSSVPKESLSRQDSSESRNGRTLSQPEASETEEQRSRGVTDTREPSPGSHSALPGKKTALQAALLETLLDLVDRSWGGCRSLHSNEAFLAQARHILSSVEEFTAAQDSSAMVGEDVGSLALESKSLQSRLAEQQQQHAREMSEVTAELHHTHKELDDLRQHLDKSLEENSRLKSLLLSMKKEVKSADTAATLNLQIAGLQTSVKRLCGEIVELKQHLEHYDKIQELTQMLQESHSSLVSTNEHLLQELSQVRAQHRAEVEQMHWSYQELKKTMALFPHSSASHGGCQAC"},{"id":"SEQ_07630","a":"O43572","g":"AKAP10","d":"A-kinase anchor protein 10, mitochondrial","L":662,"m":[{"c":"ICxE[DG]G(x){2,3}PNCFxxxxxxφΩ[ST][AT]MExxxφxxFLxSxxΩxKYxx-ψψxS","u":"47-48","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of a 47-48 aa structured segment sharing 16 identical anchor positions (IC, E, G, PNCF, ME, FL, S, KY, S) and conserved hydrophobic/aromatic/acidic positions with a 1-residue loop length difference.","i":[[328,375,"ICGEDGQVDPNCFVLAQSIVFSAMEQEHFSEFLRSHHFCKYQIEVLTS"],[465,511,"ICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYKYLNDLIHS"]]},{"c":"LxxψLxxxxφLxYFxxΩMExxxφxxψψxFWLxA-oFxS","u":38,"sp":"dispersed","x":"structured_like","cf":"high","why":"Non-overlapping 2-copy duplication of an ungapped 38 aa structured helical segment anchored by fixed L, YF, ΩME, FWLxA-oFxS motifs and conserved aliphatic/hydrophobic core positions.","i":[[126,163,"LEQVLHDTIVLPYFIQFMELRRMEHLVKFWLEAESFHS"],[380,417,"LADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQS"]]}],"s":"MRGAGPSPRQSPRTLRPDPGPAMSFFRRKVKGKEQEKTSDVKSIKASISVHSPQKSTKNHALLEAAGPSHVAINAISANMDSFSSSRTATLKKQPSHMEAAHFGDLGRSCLDYQTQETKSSLSKTLEQVLHDTIVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQSSLAEPVSPSKKHETTASFLTDSLDKRLEDSGSAQLFMTHSEGIDLNNRTNSTQNHLLLSQECDSAHSLRLEMARAGTHQVSMETQESSSTLTVASRNSPASPLKELSGKLMKSIEQDAVNTFTKYISPDAAKPIPITEAMRNDIIARICGEDGQVDPNCFVLAQSIVFSAMEQEHFSEFLRSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYKYLNDLIHSVRGDEFLGGNVSLTAPGSVGPPDESHPGSSDSSASQSSVKKASIKILKNFDEAIIVDAASLDPESLYQRTYAGKMTFGRVSDLGQFIRESEPEPDVRKSKGSMFSQAMKKWVQGNTDEAQEELAWKIAKMIVSDIMQQAQYDQPLEKSTKL"},{"id":"SEQ_07631","a":"Q76L83","g":"ASXL2","d":"Putative Polycomb group protein ASXL2","L":1435,"m":[{"c":"φ[KPR][FI][HP][PV]Sx[IVT]SP","u":10,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three tandem 10 aa repeats (0 and 1 aa gaps) within a proline/serine-rich disordered region, anchored by invariant S at position 6 and C-terminal SP plus conserved N-terminal hydrophobic/proline/aromatic positions.","i":[[619,628,"LKIPVSRISP"],[629,638,"MPFHPSQVSP"],[640,649,"ARFPVSITSP"]]}],"s":"MREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGLKEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKRKVSSSSPQSGCPSPTIPAGKVISPSQKHSKKALKQALKQQQQKKQQQQCRPSISISSNQHLSLKTVKAASDSVPAKPATWEGKQSDGQTGSPQNSNSSFSSSVKVENTLLGLGKKSFQRSERLHTRQMKRTKCADIDVETPDSILVNTNLRALINKHTFSVLPGDCQQRLLLLLPEVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPEMQVRIRQEIEKEKKVEPWKEQFFESYYGQSSGLSLEDSKKLTASPSDPKVKKTPAEQPKSMPVSEASLIRIVPVVSQSECKEEALQMSSPGRKEECESQGEVQPNFSTSSEPLLSSALNTHELSSILPIKCPKDEDLLEQKPVTSAEQESEKNHLTTASNYNKSESQESLVTSPSKPKSPGVEKPIVKPTAGAGPQETNMKEPLATLVDQSPESLKRKSSLTQEEAPVSWEKRPRVTENRQHQQPFQVSPQPFLNRGDRIQVRKVPPLKIPVSRISPMPFHPSQVSPRARFPVSITSPNRTGARTLADIKAKAQLVKAQRAAAAAAAAAAAAASVGGTIPGPGPGGGQGPGEGGEGQTARGGSPGSDRVSETGKGPTLELAGTGSRGGTRELLPCGPETQPQSETKTTPSQAQPHSVSGAQLQQTPPVPPTPAVSGACTSVPSPAHIEKLDNEKLNPTRATATVASVSHPQGPSSCRQEKAPSPTGPALISGASPVHCAADGTVELKAGPSKNIPNPSASSKTDASVPVAVTPSPLTSLLTTATLEKLPVPQVSATTAPAGSAPPSSTLPAASSLKTPGTSLNMNGPTLRPTSSIPANNPLVTQLLQGKDVPMEQILPKPLTKVEMKTVPLTAKEERGMGALIATNTTENSTREEVNERQSHPATQQQLGKTLQSKQLPQVPRPLQLFSAKELRDSSIDTHQYHEGLSKATQDQILQTLIQRVRRQNLLSVVPPSQFNFAHSGFQLEDISTSQRFMLGFAGRRTSKPAMAGHYLLNISTYGRGSESFRRTHSVNPEDRFCLSSPTEALKMGYTDCKNATGESSSSKEDDTDEESTGDEQESVTVKEEPQVSQSAGKGDTSSGPHSRETLSTSDCLASKNVKAEIPLNEQTTLSKENYLFTRGQTFDEKTLARDLIQAAQKQMAHAVRGKAIRSSPELFSSTVLPLPADSPTHQPLLLPPLQTPKLYGSPTQIGPSYRGMINVSTSSDMDHNSAVPGSQVSSNVGDVMSFSVTVTTIPASQAMNPSSHGQTIPVQAFSEENSIEGTPSKCYCRLKAMIMCKGCGAFCHDDCIGPSKLCVSCLVVR"},{"id":"SEQ_07643","a":"Q9Y6I3","g":"EPN1","d":"Epsin-1","L":576,"m":[{"c":"DPW[GRT][GPS]","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Nine copies anchored by an invariant DPW core followed by conserved small/turn-promoting positions ([GRT][GPS]), with one N-terminal copy and an eight-copy cluster separated by variable Pro/Ala/Gly/Ser-rich linkers.","i":[[31,35,"DPWGP"],[274,278,"DPWGG"],[294,298,"DPWGG"],[306,310,"DPWGG"],[319,323,"DPWRP"],[332,336,"DPWGG"],[349,353,"DPWGS"],[367,371,"DPWTP"],[377,381,"DPWGG"]]},{"c":"--[LA][QR]LQ[LM]A[LI]xxS+[ER]E","u":15,"sp":"periodic","x":"mixed","cf":"high","why":"Three regularly spaced (~10 aa linker) 15-residue amphipathic motifs sharing an N-terminal acidic pair (--), central hydrophobic/polar core (LQ[LM]A[LI]), and C-terminal S+[ER]E cap.","i":[[184,198,"EELQLQLALAMSKEE"],[209,223,"DDAQLQLALSLSREE"],[234,248,"DDLRLQMAIEESKRE"]]},{"c":"[ST]NPF[LQ][PL]","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed C-terminal copies in a Pro/Gly-rich disordered tail anchored by an invariant NPF core flanked by [ST] at -1 and [LQ][PL] at +1/+2.","i":[[501,506,"SNPFLP"],[517,522,"TNPFQP"],[571,576,"TNPFLL"]]}],"s":"MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEELQLQLALAMSKEEADQPPSCGPEDDAQLQLALSLSREEHDKEERIRRGDDLRLQMAIEESKRETGGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPFLL"},{"id":"SEQ_07649","a":"O60239","g":"SH3BP5","d":"SH3 domain-binding protein 5","L":455,"m":[{"c":"LxKKψx+AψxxSKPYΩEφ+","u":19,"sp":"dispersed","x":"structured_like","cf":"high","why":"Strongly conserved 19-aa internal duplication within the N-terminal helical bundle/coiled-coil region (~110 aa apart), sharing 9 identical anchors (L, KK, A, SKPY, E) and 6 physicochemically conserved positions (ψ, +, Ω, φ).","i":[[87,105,"LVKKIGKAVEDSKPYWEAR"],[197,215,"LEKKLKRAINKSKPYFELK"]]}],"s":"MDAALKRSRSEEPAEILPPARDEEEEEEEGMEQGLEEEEEVDPRIQGELEKLNQSTDDINRRETELEDARQKFRSVLVEATVKLDELVKKIGKAVEDSKPYWEARRVARQAQLEAQKATQDFQRATEVLRAAKETISLAEQRLLEDDKRQFDSAWQEMLNHATQRVMEAEQTKTRSELVHKETAARYNAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLTLAKGEYKMALKNLEMISDEIHERRRSSAMGPRGCGVGAEGSSTSVEDLPGSKPEPDAISVASEAFEDDSCSNFVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVVRPGSLDLPSPVSLSEFGMMFPVLGPRSECSGASSPECEVERGDRAEGAENKTSDKANNNRGLSSSSGSGGSSKSQSSTSPEGQALENRMKQLSLQCSKGRDGIIADIKMVQIG"},{"id":"SEQ_07667","a":"Q8IYM0","g":"FAM186B","d":"Protein FAM186B","L":893,"m":[{"c":"Wxx[EL]-xxx[QE][QES]xx+","u":13,"sp":"tandem","x":"mixed","cf":"high","why":"Four tandem 13-residue repeats (0-1 aa gaps, preceded by a slightly shorter divergent copy WEEEFGREMRRQL) anchored by an invariant N-terminal W, a constrained [EL] position followed by an invariant acidic (-) residue at position 5, conserved polar/acidic [QE][QES] positions, and a C-terminal basic (+) residue.","i":[[493,505,"WLEEEEMWQQRQK"],[507,519,"WALLEQEHQEKLR"],[521,533,"WNLEDLAREQQRR"],[534,546,"WVQLEKEQESPRR"]]}],"s":"MEKDDPPQLVTPTSVKAIILRIEAAQLTRAQEDISTQLSDILDNVNCVINRFQEELGYDLKENAKSQQRDPKGKKRFILLEKIASFSKDAMMKEKHLYDILRWLGDWGDTLTYEIGPRKSEEEAAALDEWIEVTEKVLPLSLIATKRGIESLTALCSTLIEGQKKRSQVSKRTFWQGWQGRSPQTSPSHPQPLSPEQMLQDQHTMNTKASEVTSMLQELLDSTMFSKGEVRAIRYMATVVENLNKALILQHKENRSLETKYRHLQMQATKELSSQRLHFQQFMEVLESRRDALLKQVEILGGRYHDLLLMKQALEFQLKKAQNATGQAEDLAEVSVDSPGPSERETLPRKETVMEESQQEPMKEEQLFSPLPPSPMAMIRDSGAIAAGHQPLSTMTVRSRVADVFGSKDTESLEPVLLPLVDRRFPKKWERPVAESLGHKDKDQEDYFQKGGLQIKFHCSKQLSLESSRQVTSESQEEPWEEEFGREMRRQLWLEEEEMWQQRQKKWALLEQEHQEKLRQWNLEDLAREQQRRWVQLEKEQESPRREPEQLGEDVERRIFTPTSRWRDLEKAELSLVPAPSRTQSAHQSRRPHLPMSPSTQQPALGKQRPMSSVEFTYRPRTRRVPTKPKKSASFPVTGTSIRRLTWPSLQISPANIKKKVYHMDMEAQRKNLQLLSEESELRLPHYLRSKALELTTTTMELGALRLQYLCHKYIFYRRLQSLRQEAINHVQIMKETEASYKAQNLYIFLENIDRLQSLRLQAWTDKQKGLEEKHRECLSSMVTMFPKLQLEWNVHLNIPEVTSPKPKKCKLPAASPRHIRPSGPTYKQPFLSRHRACVPLQMARQQGKQMEAVWKTEVASSSYAIEKKTPASLPRDQLRGHPDIPRLLTLDV"},{"id":"SEQ_07676","a":"Q92667","g":"AKAP1","d":"A-kinase anchor protein 1, mitochondrial","L":903,"m":[{"c":"NEE[GS]LDR","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Five contiguous head-to-tail 7-residue repeats in an acidic disordered region with six invariant positions (NEE-LDR) flanking a constrained [GS] choice.","i":[[306,312,"NEESLDR"],[313,319,"NEEGLDR"],[320,326,"NEEGLDR"],[327,333,"NEESLDR"],[334,340,"NEEGLDR"]]}],"s":"MAIQFRSLFPLALPGMLALLGWWWFFSRKKGHVSSHDEQQVEAGAVQLRADPAIKEPLPVEDVCPKVVSTPPSVTEPPEKELSTVSKLPAEPPALLQTHPPCRRSESSGILPNTTDMRLRPGTRRDDSTKLELALTGGEAKSIPLECPLSSPKGVLFSSKSAEVCKQDSPFSRVPRKVQPGYPVVPAEKRSSGERARETGGAEGTGDAVLGEKVLEEALLSREHVLELENSKGPSLASLEGEEDKGKSSSSQVVGPVQEEEYVAEKLPSRFIESAHTELAKDDAAPAPPVADAKAQDRGVEGELGNEESLDRNEEGLDRNEEGLDRNEESLDRNEEGLDRNEEIKRAAFQIISQVISEATEQVLATTVGKVAGRVCQASQLQGQKEESCVPVHQKTVLGPDTAEPATAEAAVAPPDAGLPLPGLPAEGSPPPKTYVSCLKSLLSSPTKDSKPNISAHHISLASCLALTTPSEELPDRAGILVEDATCVTCMSDSSQSVPLVASPGHCSDSFSTSGLEDSCTETSSSPRDKAITPPLPESTVPFSNGVLKGELSDLGAEDGWTMDAEADHSGGSDRNSMDSVDSCCSLKKTESFQNAQAGSNPKKVDLIIWEIEVPKHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGSQHHVDKALNLIGKKFKELNLTNIYAPPLPSLALPSLPMTSWLMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEITVICAAPGADGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQGAEVLLDSVMPLSDDDQFSPEADAAMSEMTGNTALLAQVTSYSPTGLPLIQLWSVVGDEVVLINRSLVERGLAQWVDSYYTSL"},{"id":"SEQ_07692","a":"O60304","g":"ZNF500","d":"Zinc finger protein 500","L":480,"m":[{"c":"[GA]-+PYxCxxCG+[GR]Fxxx[ST]x[LF]xxH[QR]R[TV]Hx","u":28,"sp":"tandem","x":"structured_like","cf":"high","why":"Five contiguous 28-residue repeats defined by strictly invariant PY, CxxCG, F, and HxRxH anchors together with conserved [GA]-+ linker residues and an internal [LF] hydrophobic position.","i":[[321,348,"ADKPYTCPECGKGFSKTSHLTKHQRTHT"],[349,376,"GERPYKCLVCGKGFSDRSNFSTHQRVHT"],[377,404,"GEKPYPCPECGKRFSQSSSLVIHRRTHS"],[405,432,"GERPYACTQCGKRFNNSSHFSAHRRTHT"],[433,460,"GEKPYTCPACGRGFRRGTDLHKHQRTHM"]]}],"s":"MATVPGLQPLPTLEQDLEQEEILIVKVEEDFCLEEEPSVETEDPSPETFRQLFRLFCYQEVAGPREALSRLWELCCRWLRPELRTKEQILELLVLEQFLTVLPGEIQARVREQQPESGEEAVVLVEGLQRKPRKHRQRGSELLSDDEVPLGIGGQFLKHQAEAQPEDLSLEEEARFSSQQPPAQLSHRPQRGPLLWPERGPPAPRHQEMASASPFLSAWSQVPVNLEDVAVYLSGEEPRCMDPAQRDAPLENEGPGIQLEDGGDGREDAPLRMEWYRVLSARCQGPGHPLPGQRPAPVRGLVRPDQPRGGPPPGRRASHGADKPYTCPECGKGFSKTSHLTKHQRTHTGERPYKCLVCGKGFSDRSNFSTHQRVHTGEKPYPCPECGKRFSQSSSLVIHRRTHSGERPYACTQCGKRFNNSSHFSAHRRTHTGEKPYTCPACGRGFRRGTDLHKHQRTHMGAGSLPTLQPVAPGGPGAKA"},{"id":"SEQ_07699","a":"O00213","g":"APBB1","d":"Amyloid beta precursor protein binding family B member 1","L":710,"m":[{"c":"Px[ST]xxψLHxQ(x){4,9}ψRφφ(x){1,4}VGRD(x){3,6}FAΩψφ(x){8,9}CHψFxCE(x){4,8}SLxEφ(x){7,8}Rxx+CL","u":"76-77","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal C-terminal duplication of a 76-77 aa structured domain separated by a 73 aa linker, anchored by 21 identical positions (including Px[ST]xxψLHxQ, VGRD, FAΩψφ, CHψFxCE, SLxEφ, and Rxx+CL) and conserved hydrophobic/basic positions.","i":[[436,512,"PQSQALLHAQPIISIRVWGVGRDSGRERDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRNARCL"],[587,662,"PATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCL"]]}],"s":"MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGPEPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSELELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLPEPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRERDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP"},{"id":"SEQ_07703","a":"Q5VUA4","g":"ZNF318","d":"Zinc finger protein 318","L":2279,"m":[{"c":"SAD[RH][RC]SS[VD][DP][HR]x[FL]","u":12,"sp":"tandem","x":"disordered_like","cf":"high","why":"Four head-to-tail 12-aa tandem repeats (residues 629-676) in a polar/charged disordered linker, anchored by invariant N-terminal SAD and internal SS motifs, basic/His positions ([RH]4, [HR]10), and a C-terminal bulky hydrophobic residue ([FL]12).","i":[[629,640,"SADRRSSVDRYF"],[641,652,"SADHCSSVDHRF"],[653,664,"SADRCSSVDHCF"],[665,676,"SADRRSSDPHRL"]]},{"c":"xSPS[PG][PH]R[GA]RR","u":10,"sp":"tandem","x":"disordered_like","cf":"high","why":"Four contiguous head-to-tail 10-aa tandem repeats (residues 58-97) in the N-terminal R/S/P-rich disordered region, defined by invariant SPS, R7, and C-terminal RR anchors flanking a conserved [PG][PH] core and [GA]8.","i":[[58,67,"RSPSGHRGRR"],[68,77,"ASPSPPRGRR"],[78,87,"VSPSPPRARR"],[88,97,"GSPSPPRGRR"]]}],"s":"MYRSSARSSVSSHRPKDDGGGGPRSGRSSGSSSGPARRSSPPPPPSGSSSRTPARRPRSPSGHRGRRASPSPPRGRRVSPSPPRARRGSPSPPRGRRLFPPGPAGFRGSSRGESRADYARDGRGDHPGDSGSRRRSPGLCSDSLEKSLRITVGNDHFCVSTPERRRLSDRLGSPVDNLEDMDRDDLTDDSVFTRSSQCSRGLERYISQEEGPLSPFLGQLDEDYRTKETFLHRSDYSPHISCHDELLRGTERNREKLKGYSIRSEERSREAKRPRYDDTVKINSMGGDHPSFTSGTRNYRQRRRSPSPRFLDPEFRELDLARRKREEEEERSRSLSQELVGVDGGGTGCSIPGLSGVLTASEPGYSLHRPEEVSVMPKKSILKKRIEVDIMEPSMQLESFSSSTSSSQDHPLYSGHPSLPLSGAIAAFASEIENKGTMVETALKEPQGNLYQWGPLPGIPKDNSPLREKFGSFLCHKDNLDLKAEGPERHTDFLLPHERASQDGSGFSRILSMLADSTSTQEKRRRSFPDIEDEEKFLYGDEEEDLKAESVPKPLGSSESEVMRQKASSLPSSAPAVKLESLEETNPEYAKIHDLLKTIGLDIGVAEISQLAARTQERLHGKKPSLRSSADRRSSVDRYFSADHCSSVDHRFSADRCSSVDHCFSADRRSSDPHRLESREAHHSNTHSPEVSHPHPPSPVDPYLLTKNSPPFLKSDHPVGHISGPEVVGSGFQSSVAVRCMLPSAPSAPIRLPHTAALSQFHMPRASQFAAARIPPNYQGPAIPPASFDAYRHYMAYAASRWPMYPTSQPSNHPVPEPHRIMPITKQATRSRPNLRVIPTVTPDKPKQKESLRGSIPAAQVPVQVSIPSLIRYNPEKISDEKNRASQKQKVIEEREKLKNDREARQKKMYYLRTELERLHKQQGEMLRKKRREKDGHKDPLLVEVSRLQDNIMKDIAELRQEAEEAEKKQSELDKVAQILGINIFDKSQKSLSDSREPTEKPGKAEKSKSPEKVSSFSNSSSNKESKVNNEKFRTKSPKPAESPQSATKQLDQPTAAYEYYDAGNHWCKDCNTICGTMFDFFTHMHNKKHTQTLDPYNRPWASKTQSEAKQDAIKRTDKITVPAKGSEFLVPISGFYCQLCEEFLGDPISGEQHVKGHQHNEKYKKYVDENPLYEERRNLDRQAGLAVVLETERRRQSELKRKLSEKPKEEKKEKKAKAVKEVKEDDKVSEKLEDQLSEGRNSPEKAENKRNTGIKLQLKEEVKKESPTSSSFGKFSWKKPEKEEEKSSLVTPSISKEEILESSKDKEDGKTEAGKAKPIKIKLSGKTVVAHTSPWMPVVTTSTQTKIRPNLPIPSTVLRKSCSATMSKPAPLNTFLSIKSSGTTAKPLPVVKESSADLLLPPDIISKAFGGEEVILKGSPEEKVVLAEKSEPSHLPEQILPPPPPPPPPPPPPPPVIPHPAAPSAAQANAILAPVKSNPVVSQTLSPGFVGPNILNPVLPVAIMASAQPAAIPSDETAPGVSESDRDQTLFSVLVRPPPPLSSVFSEQAKKLEKRNSCLATANAKDLYDIFYSSGGKGAPETKGAPETKLSGGPLANGENSNLSRTKSSDTSSTSPLNSSASQEELHQDEGLVAAPIVSNSEKPIAKTLVALGKWSVVEHVGPKSTGSTYGFLQPLTRLCQSRPYETITPKTDTLAIWTSSSFQSDTSRDISPEKSELDLGEPGPPGVEPPPQLLDIQCKESQKLVEIHLRESVNQDKESQELRKSEDCRESEIETNTELKERVKELSEGIVDEGVSTSIGPHSIDDSNLNHGNRYMWEGEVKQPNLLMIDKEAEQSNKLMTGSETPSKVVIKLSPQACSFTKAKLDSFLSEARSLLNPQDTPVKISAPELLLHSPARSAMCLTGSPQEQGVSVVSEEGLENSAPESASRTSRYRSLKLKRERSKDFQVKKIYELAVWDENKKRPETWESPEKPKTEALELQDVHPELTVTIESKALEDFEATDLKVEELTALGNLGDMPVDFCTTRVSPAHRSPTVLCQKVCEENSVSPIGCNSSDPADFEPIPSFSGFPLDSPKTLVLDFETEGERNSPNPRSVRIPSPNILKTGLTENVDRGLGGLEGTHQALDLLAGGMMPEEVKESSQLDKQESLGLELKTINSAGLGPSPCLPDLVDFVTRTSGVQKDKLCSPLSEPGDPSKCSSLELGPLQLEISNASTTEVAILQVDDDSGDPLNLVKAPVSRSPPREQVIEDNMVPQGMPEQETTVGAIQDHTESSVHN"},{"id":"SEQ_07713","a":"Q96I25","g":"RBM17","d":"Splicing factor 45","L":401,"m":[{"c":"AAI[AP]PP(x){0,14}xYEE[DQ][SD]RPRSx[ST]","u":"18-32","sp":"tandem","x":"disordered_like","cf":"high","why":"Head-to-tail tandem duplication (separated by a 2-aa SK linker) in the central disordered region sharing two strongly conserved anchor blocks—an N-terminal AAI[AP]PP motif and a C-terminal YEE[DQ][SD]RPRSx[ST] motif (12 identical positions across 18 aligned columns)—with a 14-aa insertion in the first copy.","i":[[173,204,"AAIAPPTSLVEKDKELPRDFPYEEDSRPRSQS"],[207,224,"AAIPPPVYEEQDRPRSPT"]]}],"s":"MSLYDDLGVETSDSKTEGWSKNFKLLQSQLQVKKAALTQAKSQRTKQSTVLAPVIDLKRGGSSDDRQIVDTPPHVAAGLKDPVPSGFSAGEVLIPLADEYDPMFPNDYEKVVKRQREERQRQRELERQKEIEEREKRRKDRHEASGFARRPDPDSDEDEDYERERRKRSMGGAAIAPPTSLVEKDKELPRDFPYEEDSRPRSQSSKAAIPPPVYEEQDRPRSPTGPSNSFLANMGGTVAHKIMQKYGFREGQGLGKHEQGLSTALSVEKTSKRGGKIIVGDATEKDASKKSDSNPLTEILKCPTKVVLLRNMVGAGEVDEDLEVETKEECEKYGKVGKCVIFEIPGAPDDEAVRIFLEFERVESAIKAVVDLNGRYFGGRVVKACFYNLDKFRVLDLAEQV"},{"id":"SEQ_07714","a":"Q5HY64","g":"FAM47C","d":"Putative protein FAM47C","L":1035,"m":[{"c":"[PL]EPP[EK]T[GR]VS[HS]L[RHC]","u":12,"sp":"tandem","x":"disordered_like","cf":"high","why":"Extensive head-to-tail tandem array of 12-residue proline-rich repeats (residues 188-825, with two 13-residue single-amino-acid insertion variants LEPPKTRRVSSLR and LEPPKTGRVSSLC immediately preceding the final 12-mer copy) anchored by nearly invariant EPP, T, VS, and L positions.","i":[[188,199,"PRPPETRVSCLP"],[200,211,"PEPPKTPVSSLR"],[212,223,"PEPPETGVSHLR"],[224,235,"PQPPKTQVSSLH"],[236,247,"LEPPETGVSHLR"],[248,259,"PEPPKTQVSSLH"],[260,271,"LEPPETGVSHLY"],[272,283,"LEPPGTGVSHLC"],[284,295,"PEPPKTRVSHLH"],[296,307,"REPPETGVPDLC"],[308,319,"LEPPKSRVSHLR"],[320,331,"PEPSETGVSHLH"],[332,343,"PEPPKTLVSSLH"],[344,355,"PEPPETGVSHLC"],[356,367,"PEPPETRVSPLR"],[368,379,"QLPPEAGVSHLC"],[380,391,"PEPPKTRVPPLR"],[392,403,"PETPKNGVSPLF"],[404,415,"PEPPKTRISNLR"],[416,427,"SEPPKIGVSHLC"],[428,439,"LEPPKTRGSHLR"],[440,451,"PEPPETGVSHLR"],[452,463,"PEPPKTRVSSLH"],[464,475,"LEPPETGVSHLC"],[476,487,"PEPPEKDVSHLR"],[488,499,"PEPPDTGVSHLC"],[500,511,"PEPPKTRVSHLR"],[512,523,"PEPSETGVSHLR"],[524,535,"PEPPKILVSSLH"],[536,547,"QAPPESSVSHLR"],[548,559,"PEPPETGVSHLR"],[560,571,"PEPPKTRMYSLR"],[572,583,"PEPPDTGVSHLC"],[584,595,"PEPPKTRVSSLP"],[596,607,"PEPPETGVSHLC"],[608,619,"PEPPETRVSHLR"],[620,631,"PEPPETGVSHLR"],[632,643,"PEPPKTRMYSLR"],[644,655,"PEPPNTGVSHLC"],[656,667,"PEPPKTRVSSLP"],[668,679,"PEPPETGVSHLC"],[680,691,"PEPPETRVSHLR"],[692,703,"PEPPETGVSRLH"],[704,715,"PEPPKTRVSSLH"],[716,727,"AEPPESRVSHLC"],[728,739,"PEPPETGVSHLR"],[740,751,"PEPPKPRVSSLR"],[752,763,"PEPLETRVSHLR"],[764,775,"PEPPETGVSHLH"],[776,787,"PELPKPRVSSLH"],[814,825,"PEPTKTGASHLK"]]}],"s":"MGDQRPQDRPSSPGMDSTPWYCDKPPSKYFAKRKHRRLRFPPVDTQNWVFVTEGMDDFRYGCQSPEDTLVCRRDEFLLPKISLRGPQADPKSRKKKLLKKAALFSKLSPAQPARKAFVEEVEAQLMTKHPLAMYPNLGEDMPPDLLLQVLKPLDPERKLEDAGSCEGQEKTTDEPTEPGKYPCGEFSPRPPETRVSCLPPEPPKTPVSSLRPEPPETGVSHLRPQPPKTQVSSLHLEPPETGVSHLRPEPPKTQVSSLHLEPPETGVSHLYLEPPGTGVSHLCPEPPKTRVSHLHREPPETGVPDLCLEPPKSRVSHLRPEPSETGVSHLHPEPPKTLVSSLHPEPPETGVSHLCPEPPETRVSPLRQLPPEAGVSHLCPEPPKTRVPPLRPETPKNGVSPLFPEPPKTRISNLRSEPPKIGVSHLCLEPPKTRGSHLRPEPPETGVSHLRPEPPKTRVSSLHLEPPETGVSHLCPEPPEKDVSHLRPEPPDTGVSHLCPEPPKTRVSHLRPEPSETGVSHLRPEPPKILVSSLHQAPPESSVSHLRPEPPETGVSHLRPEPPKTRMYSLRPEPPDTGVSHLCPEPPKTRVSSLPPEPPETGVSHLCPEPPETRVSHLRPEPPETGVSHLRPEPPKTRMYSLRPEPPNTGVSHLCPEPPKTRVSSLPPEPPETGVSHLCPEPPETRVSHLRPEPPETGVSRLHPEPPKTRVSSLHAEPPESRVSHLCPEPPETGVSHLRPEPPKPRVSSLRPEPLETRVSHLRPEPPETGVSHLHPELPKPRVSSLHLEPPKTRRVSSLRLEPPKTGRVSSLCPEPTKTGASHLKELFQEGTSSTMECVSDSLQRRHTSRKLRDFKWAGDLGVNEESISSLFDFTPECRATYQDQKNKKANECSSGLKYSMELDEMDEVKFFSQEKDLDGKIQNAPNSHSAQHVKMGYGAWYLKPKLGKKLRSDEPLIDPKLVLEKPDEPDILDGLYGPIAFKDFILSKGYEMPGIIQRLFARRGWTYDSVKTPIQRAMQVYKYKEDVTDASEED"},{"id":"SEQ_07721","a":"Q8NFP9","g":"NBEA","d":"Neurobeachin","L":2946,"m":[{"c":"xxx[HD](x){10,18}xψ[IV][CST]Gxxx[GAK]xxxφx","u":"28-36","sp":"dispersed","x":"structured_like","cf":"high","why":"Five C-terminal beta-propeller-like repeats (28-36 aa) anchored by an N-terminal [HD] turn residue, an invariant G preceded by a conserved aliphatic-polar beta-strand core (ψ[IV][CST]G), and a C-terminal hydrophobic-aromatic/His dyad (φ plus W/F/Y/H) separated by variable internal loops and linkers.","i":[[2678,2705,"INAHCFVVTADNRYILICGFWDKSFRVY"],[2716,2751,"VFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLW"],[2776,2807,"LTGHDHEVVCVSVCAELGLVISGAKEGPCLVH"],[2860,2889,"EINDSTRAILLSSDGQNLVTGGDNGVVEVW"],[2901,2931,"PGCDAGIRAMDLSHDQRTLITGMASGSIVAF"]]}],"s":"MASEKPGPGPGLEPQPVGLIAVGAAGGGGGGSGGGGTGGSGMGELRGASGSGSVMLPAGMINPSVPIRNIRMKFAVLIGLIQVGEVSNRDIVETVLNLLVGGEFDLEMNFIIQDAESITCMTELLEHCDVTCQAEIWSMFTAILRKSVRNLQTSTEVGLIEQVLLKMSAVDDMIADLLVDMLGVLASYSITVKELKLLFSMLRGESGIWPRHAVKLLSVLNQMPQRHGPDTFFNFPGCSAAAIALPPIAKWPYQNGFTLNTWFRMDPLNNINVDKDKPYLYCFRTSKGVGYSAHFVGNCLIVTSLKSKGKGFQHCVKYDFQPRKWYMISIVHIYNRWRNSEIRCYVNGQLVSYGDMAWHVNTNDSYDKCFLGSSETADANRVFCGQLGAVYVFSEALNPAQIFAIHQLGPGYKSTFKFKSESDIHLAEHHKQVLYDGKLASSIAFTYNAKATDAQLCLESSPKENASIFVHSPHALMLQDVKAIVTHSIHSAIHSIGGIQVLFPLFAQLDNRQLNDSQVETTVCATLLAFLVELLKSSVAMQEQMLGGKGFLVIGYLLEKSSRVHITRAVLEQFLSFAKYLDGLSHGAPLLKQLCDHILFNPAIWIHTPAKVQLSLYTYLSAEFIGTATIYTTIRRVGTVLQLMHTLKYYYWVINPADSSGITPKGLDGPRPSQKEIISLRAFMLLFLKQLILKDRGVKEDELQSILNYLLTMHEDENIHDVLQLLVALMSEHPASMIPAFDQRNGIRVIYKLLASKSESIWVQALKVLGYFLKHLGHKRKVEIMHTHSLFTLLGERLMLHTNTVTVTTYNTLYEILTEQVCTQVVHKPHPEPDSTVKIQNPMILKVVATLLKNSTPSAELMEVRRLFLSDMIKLFSNSRENRRCLLQCSVWQDWMFSLGYINPKNSEEQKITEMVYNIFRILLYHAIKYEWGGWRVWVDTLSIAHSKVTYEAHKEYLAKMYEEYQRQEEENIKKGKKGNVSTISGLSSQTTGAKGGMEIREIEDLSQSQSPESETDYPVSTDTRDLLMSTKVSDDILGNSDRPGSGVHVEVHDLLVDIKAEKVEATEVKLDDMDLSPETLVGGENGALVEVESLLDNVYSAAVEKLQNNVHGSVGIIKKNEEKDNGPLITLADEKEDLPNSSTSFLFDKIPKQEEKLLPELSSNHIIPNIQDTQVHLGVSDDLGLLAHMTGSVDLTCTSSIIEEKEFKIHTTSDGMSSISERDLASSTKGLEYAEMTATTLETESSSSKIVPNIDAGSIISDTERSDDGKESGKEIRKIQTTTTTQAVQGRSITQQDRDLRVDLGFRGMPMTEEQRRQFSPGPRTTMFRIPEFKWSPMHQRLLTDLLFALETDVHVWRSHSTKSVMDFVNSNENIIFVHNTIHLISQMVDNIIIACGGILPLLSAATSPTGSKTELENIEVTQGMSAETAVTFLSRLMAMVDVLVFASSLNFSEIEAEKNMSSGGLMRQCLRLVCCVAVRNCLECRQRQRDRGNKSSHGSSKPQEVPQSVTATAASKTPLENVPGNLSPIKDPDRLLQDVDINRLRAVVFRDVDDSKQAQFLALAVVYFISVLMVSKYRDILEPQRETTRTGSQPGRNIRQEINSPTSTVVVIPSIPHPSLNHGFLAKLIPEQSFGHSFYKETPAAFPDTIKEKETPTPGEDIQVESSIPHTDSGIGEEQVASILNGAELETSTGPDAMSELLSTLSSEVKKSQESLTENPSETLKPATSISSISQTKGINVKEILKSLVAAPVEIAECGPEPIPYPDPALKRETQAILPMQFHSFDRSVVVPVKKPPPGSLAVTTVGATTAGSGLPTGSTSNIFAATGATPKSMINTTGAVDSGSSSSSSSSSFVNGATSKNLPAVQTVAPMPEDSAENMSITAKLERALEKVAPLLREIFVDFAPFLSRTLLGSHGQELLIEGLVCMKSSTSVVELVMLLCSQEWQNSIQKNAGLAFIELINEGRLLCHAMKDHIVRVANEAEFILNRQRAEDVHKHAEFESQCAQYAADRREEEKMCDHLISAAKHRDHVTANQLKQKILNILTNKHGAWGAVSHSQLHDFWRLDYWEDDLRRRRRFVRNAFGSTHAEALLKAAIEYGTEEDVVKSKKTFRSQAIVNQNAETELMLEGDDDAVSLLQEKEIDNLAGPVVLSTPAQLIAPVVVAKGTLSITTTEIYFEVDEDDSAFKKIDTKVLAYTEGLHGKWMFSEIRAVFSRRYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQLYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPGNFRDLSKPIGALNPKRAVFYAERYETWEDDQSPPYHYNTHYSTATSTLSWLVRIEPFTTFFLNANDGKFDHPDRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYNLGVREDEVVVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLCFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLFAVNRWHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKRQITDLVDQSIQINAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTITGDLLRALEGPENCLFPRLISVSSEGHCIIYYERGRFSNFSINGKLLAQMEINDSTRAILLSSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMASGSIVAFNIDFNRWHYEHQNRY"},{"id":"SEQ_07726","a":"Q8NC56","g":"LEMD2","d":"LEM domain-containing protein 2","L":503,"m":[{"c":"R[LP]R[GDE]-[AE]","u":6,"sp":"tandem","x":"disordered_like","cf":"high","why":"Six contiguous tandem copies of a 6-residue motif in the N-terminal disordered region anchored by invariant R at positions 1 and 3, L/P at position 2, G/D/E at position 4, an invariant acidic residue at position 5, and A/E at position 6.","i":[[37,42,"RLRGEA"],[43,48,"RLRDEE"],[49,54,"RLREEA"],[55,60,"RPRGEE"],[61,66,"RLREEA"],[67,72,"RLREDA"]]}],"s":"MAGLSDLELRRELQALGFQPGPITDTTRDVYRNKLRRLRGEARLRDEERLREEARPRGEERLREEARLREDAPLRARPAAASPRAEPWLSQPASGSAYATPGAYGDIRPSAASWVGSRGLAYPARPAQLRRRASVRGSSEEDEDARTPDRATQGPGLAARRWWAASPAPARLPSSLLGPDPRPGLRATRAGPAGAARARPEVGRRLERWLSRLLLWASLGLLLVFLGILWVKMGKPSAPQEAEDNMKLLPVDCERKTDEFCQAKQKAALLELLHELYNFLAIQAGNFECGNPENLKSKCIPVMEAQEYIANVTSSSSAKFEAALTWILSSNKDVGIWLKGEDQSELVTTVDKVVCLESAHPRMGVGCRLSRALLTAVTNVLIFFWCLAFLWGLLILLKYRWRKLEEEEQAMYEMVKKIIDVVQDHYVDWEQDMERYPYVGILHVRDSLIPPQSRRRMKRVWDRAVEFLASNESRIQTESHRVAGEDMLVWRWTKPSSFSDSER"},{"id":"SEQ_07738","a":"Q2TB10","g":"ZNF800","d":"Zinc finger protein 800","L":664,"m":[{"c":"CxxCxxxxxxxxxψxxH(x){3,4}[HC]","u":"21-22","sp":"dispersed","x":"structured_like","cf":"high","why":"Seven dispersed 21-22 aa C2H2/C2HC zinc-finger-like repeats sharing an invariant CxxC N-terminal pair, a conserved large aliphatic (L/V) 10 residues after the second Cys, and a H(x){3,4}[HC] C-terminal pair.","i":[[71,92,"CKLCRSLFRGLPNLITHKKFYC"],[232,253,"CCLCRKEFNSRRGVRRHIRKVH"],[289,310,"CPVCCKSFATKANVRRHFDEVH"],[361,382,"CLLCKRKYSSQIMLKRHMQIVH"],[488,508,"CKLCKRQFTSKQNLTKHIELH"],[521,542,"CPLCTYETRRKRDVIRHITVVH"],[620,640,"CNKCGKAFAKKTYLEHHKKTH"]]}],"s":"MPLRDKYCQTDHHHHGCCEPVYILEPGDPPLLQQPLQTSKSGIQQIIECFRSGTKQLKHILLKDVDTIFECKLCRSLFRGLPNLITHKKFYCPPSLQMDDNLPDVNDKQSQAINDLLEAIYPSVDKREYIIKLEPIETNQNAVFQYISRTDNPIEVTESSSTPEQTEVQIQETSTEQSKTVPVTDTEVETVEPPPVEIVTDEVAPTSDEQPQESQADLETSDNSDFGHQLICCLCRKEFNSRRGVRRHIRKVHKKKMEELKKYIETRKNPNQSSKGRSKNVLVPLSRSCPVCCKSFATKANVRRHFDEVHRGLRRDSITPDIATKPGQPLFLDSISPKKSFKTRKQKSSSKAEYNLTACKCLLCKRKYSSQIMLKRHMQIVHKITLSGTNSKREKGPNNTANSSEIKVKVEPADSVESSPPSITHSPQNELKGTNHSNEKKNTPAAQKNKVKQDSESPKSTSPSAAGGQQKTRKPKLSAGFDFKQLYCKLCKRQFTSKQNLTKHIELHTDGNNIYVKFYKCPLCTYETRRKRDVIRHITVVHKKSSRYLGKITASLEIRAIKKPIDFVLNKVAKRGPSRDEAKHSDSKHDGTSNSPSKKYEVADVGIEVKVTKNFSLHRCNKCGKAFAKKTYLEHHKKTHKANASNSPEGNKTKGRSTRSKALV"},{"id":"SEQ_07744","a":"P0CJ90","g":"DUX4L7","d":"Double homeobox protein 4-like protein 7","L":424,"m":[{"c":"GRR+RxφφT[PG]SQ[ST]xφLxxxFE+[ND]xΩPGIA[TA]RExLAxxxGψPE[PS]RψQIWFQNxR[SA]R","u":55,"sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of a 55-residue structured domain separated by a 20-residue linker, exhibiting 60% sequence identity (33/55 identical positions including GRR, SQ, FE, PGIA, GψPE, and QIWFQN) with no indels.","i":[[19,73,"GRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSR"],[94,148,"GRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRAR"]]}],"s":"MALPTPSDSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQHRRESRPWPGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARHPGQGGRAPAQAGGLCSAAPGGGHPAPSWVAFAHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGVSQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLPGPCAVAQPGPAQAGPQGQGVLAPPTSQGSPWWGWGRGPQVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQEPAPWSALPCGLLLDELLASPEFLQQAQPLLETEAPGELEASEEAASLEAPLSEEEYRALLEEL"},{"id":"SEQ_07764","a":"Q9NWS9","g":"ZNF446","d":"Zinc finger protein 446","L":450,"m":[{"c":"+x[YH]xC[ES][QED]CG[RC][GSA]F[DS]WKS[QV][FL]VIH[RH]+[TSG]H[TR]","u":26,"sp":"dispersed","x":"structured_like","cf":"high","why":"Three highly conserved 26-aa CxxC...HxxxH repeats anchored by invariant C-x2-C-G, F-[DS]-W-K-S, and V-I-H-[RH]-+-x-H positions, separated by a 37-aa linker between copies 1-2 and a 2-aa gap between copies 2-3.","i":[[330,355,"KPYTCEQCGRGFDWKSVFVIHHRTHT"],[393,418,"RSYPCEECGCSFSWKSQLVIHRKSHT"],[421,446,"RRHFCSDCGRAFDWKSQLVIHRKGHR"]]}],"s":"MPSPLGPPCLPVMDPETTLEEPETARLRFRGFCYQEVAGPREALARLRELCCQWLQPEAHSKEQMLEMLVLEQFLGTLPPEIQAWVRGQRPGSPEEAAALVEGLQHDPGQLLGWITAHVLKQEVLPAAQKTEEPLGSPHPSGTVESPGEGPQDTRIEGSVQLSCSVKEEPNVDGQEVAPSSPPLAAQSPEGNHGHQEPASTSFHPPRIQEEWGLLDRSQKELYWDAMLEKYGTVVSLGLPPHQPEAQAQSELGMLLTGTGVCRSLRSGNESEGPPGCPEAQPPQGPGPAAWEGLSGAATPAPTVRPGTPPVPTQPTPAETRLEPAATPRKPYTCEQCGRGFDWKSVFVIHHRTHTSGPGVQSPGLATGESTEKPPQGEVAFPHHPRRSLTGPRSYPCEECGCSFSWKSQLVIHRKSHTGQRRHFCSDCGRAFDWKSQLVIHRKGHRPEVP"},{"id":"SEQ_07768","a":"Q9NUA8","g":"ZBTB40","d":"Zinc finger and BTB domain-containing protein 40","L":1239,"m":[{"c":"φxCxxCxxxΩxxxxxψxxH(x){3,4}[HC]","u":"23-24","sp":"periodic","x":"structured_like","cf":"high","why":"Fourteen C2H2-type (with one N-terminal C2HC variant) zinc-finger repeats in the C-terminal half featuring invariant CxxC and H(x){3,4}[HC] coordination anchors plus conserved aromatic (F/Y in 13/14 copies) and aliphatic (L/M in 12/14 copies) core positions, arranged predominantly with regular 4-7 aa linkers interrupted by two 17 aa inter-cluster linkers.","i":[[736,758,"FICKACDKSFHFYCRLKVHMKRC"],[766,789,"VQCKECSETKDSKKELDKHQLEAH"],[807,830,"VTCDLCGREFAHASGMQYHKLTEH"],[836,858,"FSCEECGAKFAANSTLKNHLRLH"],[864,887,"FMCKHCLMTFTQASALAYHTKKKH"],[893,915,"YACQYCDAVFAQSIELSRHVRTH"],[921,944,"YVCRDCGKGFRQANGLSIHLHTFH"],[950,973,"YDCKKCRMSFPTLQDHRKHIHEVH"],[978,1000,"HPCPTCGKIFSAPSMLERHVVTH"],[1006,1028,"FSCGICNKAYQQLSGLWYHNRTH"],[1046,1069,"LQCSSCDKTFPNTIEHKKHIKAEH"],[1075,1098,"HECDQCKELFPTPALLQVHVKCQH"],[1104,1127,"FRCLYCAATFRFPGALQHHVTTEH"],[1135,1158,"FPCELCGELFTSQAQLDSHLESEH"]]},{"c":"xxxxxx[FLI]L(x){2,4}xxψxxxφxxxxxxφxxxxxx(x){5,9}xxψxxx[CL]xxx(x){4,6}xxxxxxψxxxxxxx(x){8,10}LL(x){7,8}Pxxxxφxxx[RL]","u":"93-97","sp":"periodic","x":"structured_like","cf":"high","why":"Four internal duplications of a ~93-97 aa multi-helical domain in the central region (residues 238-664) separated by regular 15-17 aa polar/proline-rich linkers, sharing conserved hydrophobic helix registers as well as invariant LL and Pxxxxφxxx[RL] C-terminal anchors.","i":[[238,330,"HYQLNFLLENEGVFSDALMVTQDVLKKLEMCSEIKGPQKEMIVKCFEGEGGHSAFQRILGKVREESLDVQTVVSLLRLYQYSNPAVKTALLDR"],[348,443,"KTLSVLLLEHKEDLIQCVTQLRPIMESLETAKEEFLTGTEKRVILNCCEGRTPKETIENLLHRMTEEKTLTAEGLVKLLQAVKTTFPNLGLLLEKL"],[459,555,"DDYGTELLRRYHENLSEIFTDNQILLKMISHMTSLAPGEREVMEKLVKRDSGSGGFNSLISAVLEKQTLSATAIWQLLLVVQETKTCPLDLLMEEIR"],[572,664,"HATLETILRHNQLILEAIQQKIEYKLFTSEEEHLAETVKEILSIPSETASPEASLRAVLSRAMEKSVPAIEICHLLCSVHKSFPGLQPVMQEL"]]}],"s":"MELPNYSRQLLQQLYTLCKEQQFCDCTISIGTIYFRAHKLVLAAASLLFKTLLDNTDTISIDASVVSPEEFALLLEMMYTGKLPVGKHNFSKIISLADSLQMFDVAVSCKNLLTSLVNCSVQGQVVRDVSAPSSETFRKEPEKPQVEILSSEGAGEPHSSPELAATPGGPVKAETEEAAHSVSQEMSVNSPTAQESQRNAETPAETPTTAEACSPSPAVQTFSEAKKTSTEPGCERKHYQLNFLLENEGVFSDALMVTQDVLKKLEMCSEIKGPQKEMIVKCFEGEGGHSAFQRILGKVREESLDVQTVVSLLRLYQYSNPAVKTALLDRKPEDVDTVQPKGSTEEGKTLSVLLLEHKEDLIQCVTQLRPIMESLETAKEEFLTGTEKRVILNCCEGRTPKETIENLLHRMTEEKTLTAEGLVKLLQAVKTTFPNLGLLLEKLQKSATLPSTTVQPSPDDYGTELLRRYHENLSEIFTDNQILLKMISHMTSLAPGEREVMEKLVKRDSGSGGFNSLISAVLEKQTLSATAIWQLLLVVQETKTCPLDLLMEEIRREPGADAFFRAVTTPEHATLETILRHNQLILEAIQQKIEYKLFTSEEEHLAETVKEILSIPSETASPEASLRAVLSRAMEKSVPAIEICHLLCSVHKSFPGLQPVMQELAYIGVLTKEDGEKETWKVSNKFHLEANNKEDEKAAKEDSQPGEQNDQGETGSLPGQQEKEASASPDPAKKSFICKACDKSFHFYCRLKVHMKRCRVAKSKQVQCKECSETKDSKKELDKHQLEAHGAGGEPDAPKKKKKRLPVTCDLCGREFAHASGMQYHKLTEHFDEKPFSCEECGAKFAANSTLKNHLRLHTGDRPFMCKHCLMTFTQASALAYHTKKKHSEGKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHPCPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEHADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHPKVMSTETQAAASQMAQVIQTPEPVAPTEQVITLEETQLAGSQVFVTLPDSQASQASSELVAVTVEDLLDGTVTLICGEAK"},{"id":"SEQ_07772","a":"Q13698","g":"CACNA1S","d":"Voltage-dependent L-type calcium channel subunit alpha-1S","L":1873,"m":[{"c":"IVxxxxFxxφψφφxψφφ[NS][CST]φ[ACS]ψ[AG](x){24,27}F[ST]xEφφ[LM]Kψ(x){12,16}[FW]Nx[FL]Dxx[IV]Vxx[GS]ψφ(x){13,38}φ[FL]RxφR[LV][LM]Rxφ+φxxxφx[GS][LV]xx[LV][LV]x[CST]φφx[AS]φxx[IL]xxψφL[LV]xxφφxφ[IM][FY]Ax[IL]Gψ[EQ][LM]F[GK][GK](x){13,54}F[DQ][NT][FV]xx[AS]ψψ[LST][LV][FY]x[CV]xTxE[ADG]Wxxψ[LM](x){14,30}[FY]F[IV]xφφψ[CL]xx[FY]φψψNψ[FV][LV][AG]φφxxx[FL]","u":"237-291","sp":"dispersed","x":"structured_like","cf":"high","why":"Four large homologous hydrophobic multi-segment domain duplications separated by variable linkers (47-129 aa), each sharing six conserved core blocks anchored by invariant motifs including N-terminal IVxxxxF, F[ST]xEφφ[LM]Kψ, [FW]Nx[FL]D, periodic RxxRxxRxx+ amphipathic segments coupled to Ax[IL]Gψ[EQ][LM]F[GK][GK], a conserved F[DQ][NT][FV]...TxE[ADG]W segment, and a C-terminal [FY]F[IV]...Nψ[FV][LV][AG]φφxxx[FL] helix.","i":[[47,337,"IVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEF"],[428,664,"IVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNL"],[795,1068,"IVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTF"],[1114,1384,"IVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNF"]]}],"s":"MEPSSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSKGLPDKSEEEKSTMAKKLEQKPKGEGIPTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPPVMANQRPLQFAEIEMEEMESPVFLEDFPQDPRTNPLARANTNNANANVAYGNSNHSNSHVFSSVHYEREFPEETETPATRGRALGQPCRVLGPHSKPCVEMLKGLLTQRAMPRGQAPPAPCQCPRVESSMPEDRKSSTPGSLHEETPHSRSTRENTSRCSAPATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKGREAPEGMASSLGCLNLGSSLGSLDQHQGSQETLIPPRL"},{"id":"SEQ_07776","a":"Q9BRL6","g":"SRSF8","d":"Serine/arginine-rich splicing factor 8","L":282,"m":[{"c":"SxY[GSR]x","u":5,"sp":"tandem","x":"disordered_like","cf":"high","why":"Unbroken 11-copy head-to-tail pentapeptide array within the C-terminal polar/charged disordered region, defined by invariant S at position 1, an invariant aromatic Y anchor at position 3, constrained [GSR] at position 4, and strong R/P enrichment at flanking positions (canonical S[RP]YSR).","i":[[148,152,"SRYRG"],[153,157,"SRYSR"],[158,162,"SPYSR"],[163,167,"SPYSR"],[168,172,"SRYSR"],[173,177,"SPYSR"],[178,182,"SRYRE"],[183,187,"SRYGG"],[188,192,"SHYSS"],[193,197,"SGYSN"],[198,202,"SRYSR"]]}],"s":"MSCGRPPPDVDGMITLKVDNLTYRTSPDSLRRVFEKYGRVGDVYIPREPHTKAPRGFAFVRFHDRRDAQDAEAAMDGAELDGRELRVQVARYGRRDLPRSRQGEPRGRSRGGGYGRRSRSYGRRSRSPRRRHRSRSRGPSCSRSRSRSRYRGSRYSRSPYSRSPYSRSRYSRSPYSRSRYRESRYGGSHYSSSGYSNSRYSRYHSSRSHSKSGSSTSSRSASTSKSSSARRSKSSSVSRSRSRSRSSSMTRSPPRVSKRKSKSRSRSKRPPKSPEEEGQMSS"},{"id":"SEQ_07799","a":"O60481","g":"ZIC3","d":"Zinc finger protein ZIC 3","L":467,"m":[{"c":"C(x){2,14}C(x){3,6}[FY]xxxxxxxxH(x){3,4}H","u":"21-34","sp":"periodic","x":"structured_like","cf":"high","why":"Five periodic 21-34 aa repeats defined by two invariant N-terminal cysteines, a conserved aromatic ([FY]) positioned exactly eight residues before an invariant histidine, and a second invariant histidine 3-4 residues C-terminal. Copies 2-5 are separated by conserved 7-residue T[GS][ED]KP[FY]x linkers (and copy 1 by a 10-residue linker).","i":[[253,286,"CKWIDEAQLSRPKKSCDRTFSTMHELVTHVTMEH"],[297,322,"CYWEECPREGKSFKAKYKLVNHIRVH"],[330,352,"CPFPGCGKIFARSENLKIHKRTH"],[360,382,"CEFEGCDRRFANSSDRKKHMHVH"],[390,410,"CKVCDKSYTHPSSLRKHMKVH"]]}],"s":"MTMLLDGGPQFPGLGVGSFGAPRHHEMPNREPAGMGLNPFGDSTHAAAAAAAAAAFKLSPAAAHDLSSGQSSAFTPQGSGYANALGHHHHHHHHHHHTSQVPSYGGAASAAFNSTREFLFRQRSSGLSEAASGGGQHGLFAGSASSLHAPAGIPEPPSYLLFPGLHEQGAGHPSPTGHVDNNQVHLGLRGELFGRADPYRPVASPRTDPYAAGAQFPNYSPMNMNMGVNVAAHHGPGAFFRYMRQPIKQELSCKWIDEAQLSRPKKSCDRTFSTMHELVTHVTMEHVGGPEQNNHVCYWEECPREGKSFKAKYKLVNHIRVHTGEKPFPCPFPGCGKIFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYICKVCDKSYTHPSSLRKHMKVHESQGSDSSPAASSGYESSTPPAIASANSKDTTKTPSAVQTSTSHNPGLPPNFNEWYV"},{"id":"SEQ_07818","a":"Q96JM2","g":"ZNF462","d":"Zinc finger protein 462","L":2506,"m":[{"c":"φxCxxC(x){9,10}φxxH(x){3,4}H","u":"23-25","sp":"dispersed","x":"structured_like","cf":"high","why":"34 copies of a structured 23-25 aa repeat anchored by a conserved N-terminal hydrophobic/aromatic residue (33/34 φ, 30/34 Y/F), an invariant CxxC pair, a strictly conserved hydrophobic residue three positions upstream of an invariant H(x){3,4}H motif, distributed across the sequence with variable linkers from 5 to >200 residues.","i":[[4,27,"LQCDGCDFRAPSYEDLKAHIQDVH"],[108,131,"FQCKFCVRYFRSKNLLIEHTRKVH"],[162,185,"FSCQFCTYKSPRRARIIKHQKMYH"],[243,266,"FCCEWCSYQTPRRERWCDHMMKKH"],[439,462,"FQCPFCPFLTMHRRSISRHIENIH"],[470,492,"YKCDECPFTCKSSLKLGAHKQCH"],[600,623,"YKCTMCNYSTTTLKGLRVHQQHKH"],[843,866,"YYCKHCDFNNKSARSVSTHYQRMH"],[886,909,"YRCLECYIDYTNFEDLQQHYGEHH"],[925,948,"YRCRFCSYTSPNVRSLMPHYQRMH"],[1030,1053,"YDCDVCSFASPNMHSVLVHYQKKH"],[1114,1137,"YYCKHCSYSNRSVVGVLVHYQKRH"],[1193,1216,"FFCQHCDYGNRTVKGVLIHYQKKH"],[1265,1288,"LKCRQCSYTSPYFYALRKHIKKDH"],[1312,1335,"YHCEWCIYSHTEPNGLLLHYQRRH"],[1369,1392,"YRCRDCVFEAVSIWDITNHYQAFH"],[1470,1493,"YQCTVCQSEYNNLHGLLTHYGKKH"],[1515,1538,"YKCRHCPYINTRIHGVLTHYQKRH"],[1577,1600,"YRCKLCPYTHGTLEKLKIHYEKYH"],[1660,1683,"FRCQLCKYFCSTRKGIARHYRIKH"],[1697,1720,"FKCALCAYTNPIRKGLAAHYQKRH"],[1767,1790,"KKCSLCSFQSFSKKGIVSHYMKRH"],[1846,1870,"FRCIKCFKLSFSTAELLCMHYTDHH"],[1892,1914,"YQCKHCDSKLQSTAELTSHLNIH"],[1968,1990,"YKCKFCVEVHPTLRAICNHLRKH"],[2025,2048,"YSCQYCSFVSAFRHNLDRHMQTHH"],[2054,2077,"FRCKLCSFKSSYNSRLKTHILKAH"],[2083,2106,"YKCSWCSFSTMTISQLKEHSLKVH"],[2191,2214,"LHCEFCEFSSGYIQSIRRHYRDKH"],[2220,2243,"FKCKDCSFYTGFKSAFTMHVEAGH"],[2254,2276,"LRCPLCLYHTKYKRNMIDHIVLH"],[2300,2322,"FRCDKCTFTCSSDESLQQHIEKH"],[2328,2351,"YKCQLCYYETKHTEELDSHLRDEH"],[2414,2436,"FPCEFCGRAFSQGSEWERHVLRH"]]}],"s":"MEVLQCDGCDFRAPSYEDLKAHIQDVHTAFLQPTDVAEDNVNELRCGSVNASNQTEVEFSSIKDEFAIAEDLSGQNATSLGTGGYYGHSPGYYGQHIAANPKPTNKFFQCKFCVRYFRSKNLLIEHTRKVHGAQAEGSSSGPPVPGSLNYNIMMHEGFGKVFSCQFCTYKSPRRARIIKHQKMYHKNNLKETTAPPPAPAPMPDPVVPPVSLQDPCKELPAEVVERSILESMVKPLTKSRGNFCCEWCSYQTPRRERWCDHMMKKHRSMVKILSSLRQQQEGTNLPDVPNKSAPSPTSNSTYLTMNAASREIPNTTVSNFRGSMGNSIMRPNSSASKFSPMSYPQMKPKSPHNSGLVNLTERSRYGMTDMTNSSADLETNSMLNDSSSDEELNEIDSENGLSAMDHQTSGLSAEQLMGSDGNKLLETKGIPFRRFMNRFQCPFCPFLTMHRRSISRHIENIHLSGKTAVYKCDECPFTCKSSLKLGAHKQCHTGTTSDWDAVNSQSESISSSLNEGVVSYESSSINGRKSGVMLDPLQQQQPPQPPPPPPPPPPSQPQPLQQPQPPQLQPPHQVPPQPQTQPPPTQQPQPPTQAAPLHPYKCTMCNYSTTTLKGLRVHQQHKHSFCDNLPKFEGQPSSLPLENETDSHPSSSNTVKKSQTSILGLSSKNNFVAKASRKLANDFPLDLSPVKKRTRIDEIASNLQSKINQTKQQEDAVINVEDDEEEEEDNEVEIEVELDREEEPTEPIIEVPTSFSAQQIWVRDTSEPQKEPNFRNITHDYNATNGAEIELTLSEDEEDYYGSSTNLKDHQVSNTALLNTQTPIYGTEHNSENTDFGDSGRLYYCKHCDFNNKSARSVSTHYQRMHPYIKFSFRYILDPNDHSAVYRCLECYIDYTNFEDLQQHYGEHHPEAMNVLNFDHSDLIYRCRFCSYTSPNVRSLMPHYQRMHPTVKINNAMIFSSYVVEQQEGLNTESQTLREILNSAPKNMATSTPVARGGGLPATFNKNTPKTFTPECENQKDPLVNTVVVYDCDVCSFASPNMHSVLVHYQKKHPEEKASYFRIQKTMRMVSVDRGSALSQLSFEVGAPMSPKMSNMGSPPPPQPPPPDLSTELYYCKHCSYSNRSVVGVLVHYQKRHPEIKVTAKYIRQAPPTAAMMRGVEGPQGSPRPPAPIQQLNRSSSERDGPPVENEMFFCQHCDYGNRTVKGVLIHYQKKHRDFKANADVIRQHTATIRSLCDRNQKKPASCVLVSPSNLERDKTKLRALKCRQCSYTSPYFYALRKHIKKDHPALKATVTSIMRWAFLDGLIEAGYHCEWCIYSHTEPNGLLLHYQRRHPEHYVDYTYMATKLWAGPDPSPPSLTMPAEAKTYRCRDCVFEAVSIWDITNHYQAFHPWAMNGDESVLLDIIKEKDAVEKPILSSEELAGPVNCENSIPTPFPEQEAECPEDARLSPEKSLQLASANPAISSTPYQCTVCQSEYNNLHGLLTHYGKKHPGMKVKAADFAQDIDINPGAVYKCRHCPYINTRIHGVLTHYQKRHPSIKVTAEDFVHDVEQSADISQNDVEETSRIFKQGYGAYRCKLCPYTHGTLEKLKIHYEKYHNQPEFDVFSQSPPKLPVPLEPEMTTEVSPSQVSITEEEVGEEPVSTSHFSTSHLVSHTVFRCQLCKYFCSTRKGIARHYRIKHNNVRAQPEGKNNLFKCALCAYTNPIRKGLAAHYQKRHDIDAYYTHCLAASRTISDKPNKVIIPSPPKDDSPQLSEELRRAVEKKKCSLCSFQSFSKKGIVSHYMKRHPGVFPKKQHASKLGGYFTAVYADEHEKPTLMEEEERGNFEKAEVEGEAQEIEWLPFRCIKCFKLSFSTAELLCMHYTDHHSRDLKRDFIILGNGPRLQNSTYQCKHCDSKLQSTAELTSHLNIHNEEFQKRAKRQERRKQLLSKQKYADGAFADFKQERPFGHLEEVPKIKERKVVGYKCKFCVEVHPTLRAICNHLRKHVQYGNVPAVSAAVKGLRSHERSHLALAMFTREDKYSCQYCSFVSAFRHNLDRHMQTHHGHHKPFRCKLCSFKSSYNSRLKTHILKAHAGEHAYKCSWCSFSTMTISQLKEHSLKVHGKALTLPRPRIVSLLSSHSHHSSQKATPAEEVEDSNDSSYSEPPDVQQQLNHYQSAALARNNSRVSPVPLSGAAAGTEQKTEAVLHCEFCEFSSGYIQSIRRHYRDKHGGKKLFKCKDCSFYTGFKSAFTMHVEAGHSAVPEEGPKDLRCPLCLYHTKYKRNMIDHIVLHREERVVPIEVCRSKLSKYLQGVVFRCDKCTFTCSSDESLQQHIEKHNELKPYKCQLCYYETKHTEELDSHLRDEHKVSRNFELVGRVNLDQLEQMKEKMESSSSDDEDKEEEMNSKAEDRELMRFSDHGAALNTEKRFPCEFCGRAFSQGSEWERHVLRHGMALNDTKQVSREEIHPKEIMENSVKMPSIEEKEDDEAIGIDFSLKNETVAICVVTADKSLLENAEAKKE"},{"id":"SEQ_07822","a":"Q16665","g":"HIF1A","d":"Hypoxia-inducible factor 1-alpha","L":826,"m":[{"c":"MxφK(x){3,5}W(x){2,5}TxxxxψY[DN]T[NK]ooQPQC","u":"28-29","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of a 28-29 aa structured segment separated by a 96 aa linker, anchored by 10 invariant residues (N-terminal M and K, internal W and T, and a C-terminal YxTxooQPQC signature) alongside conserved hydrophobic/aliphatic positions and two short variable-length loops.","i":[[182,210,"MNIKSATWKVLHCTGHIHVYDTNSNQPQC"],[307,334,"MLAKRGGYVWVETQATVIYNTKNSQPQC"]]}],"s":"MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN"},{"id":"SEQ_07826","a":"P13569","g":"CFTR","d":"Cystic fibrosis transmembrane conductance regulator","L":1480,"m":[{"c":"ψLxxIoFxIxxGQxψ[AG]ψφGxTG[AS]GK[ST][ST]LLxφφψxxLx(x){27,29}xxφIFxx[ST]Ω(x){26,36}φVLx-GGxxLSxGx+xxψxLAR[AS]VφxxAxψφLLDxPx[GA]xLDxψTxxxIx(x){10,11}TxILxxx+ψExψxxxxxφLψψxE","u":"182-193","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of a ~185-residue structured domain in the first and second halves of the protein sharing highly conserved signature blocks including GxTG[AS]GK[ST][ST]LL, φIFxx[ST]Ω, LSxGx+xxψxLAR[AS]V, and φLLDxPx[GA]xLD separated by minor variable-length loops.","i":[[440,621,"VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHE"],[1226,1418,"ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEE"]]},{"c":"R+xSψφ","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Six dispersed copies clustered within the central polar/charged disordered linker (residues 659-801), defined by an invariant N-terminal R followed by a basic residue (+), an invariant S at position 4, and conserved C-terminal aliphatic/hydrophobic positions (ψφ).","i":[[657,662,"RRNSIL"],[697,702,"RKNSIL"],[709,714,"RKFSIV"],[734,739,"RRLSLV"],[765,770,"RRQSVL"],[792,797,"RKVSLA"]]}],"s":"MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL"},{"id":"SEQ_07828","a":"A6NNC1","g":"P12LL_HUMAN","d":"Putative POM121-like protein 1-like","L":897,"m":[{"c":"AQ[SR]SE[IV]RYN[HQ][TR]SQTSxT[SR]S[SC]xKRNA[IS]SSS(x){0,2}[YH]SST[GE]GL[PQ][GE]LK[QR]RRGPASS[RH]CQL[TA][LH]S[YS]S[KN]TVSED[RG]PQAVSSGH(x){0,1}RCE[KN][GK]A[DG]TAPGQT[IL]AP[TR]GG[SY]PRSQ[DA]SRP[RH](x){0,42}INSAL[HY]VEDKAI[PS]DCRPSRPSHTLSSLATGASGGPPVSKAPTMDAQQDRPKSQD[SC]LGL[LV]APLASAAEV[PS]STAPVSGKKHRPPGPLFSSSDPLPATS[YS]HS[RG]D[TS]AQ[VD]TSLIPA[TP]FT[AP]ASRDAG[MI]RR","u":"225-268","sp":"periodic","x":"mixed","cf":"high","why":"Three highly conserved 225-268 aa internal duplications separated by regular 44-47 aa homologous linkers; copies share >75-95% sequence identity across extensive invariant blocks (including SE[IV]RYN, RRGPASS, DCRPSRPSHTLSSLATGASGGPPVSKAPTMDAQQDRPKSQD, STAPVSGKKHRPPGPLFSSSDPLPATS, and ASRDAG[MI]RR), with copy 1 carrying a 42-aa internal insertion.","i":[[56,323,"AQSSEIRYNHTSQTSWTSSSTKRNAISSSYSSTGGLPGLKQRRGPASSRCQLTLSYSKTVSEDRPQAVSSGHTRCEKGADTAPGQTIAPTGGSPRSQDSRPRRRKIPLLPRRRGEPLMLPPPLELGYRVTAEDLHLEKETAFQRINSALHVEDKAIPDCRPSRPSHTLSSLATGASGGPPVSKAPTMDAQQDRPKSQDSLGLLAPLASAAEVPSTAPVSGKKHRPPGPLFSSSDPLPATSYHSRDTAQVTSLIPATFTAASRDAGMRR"],[368,594,"AQRSEVRYNQRSQTSRTRSCLKRNASSSSSSHSSTEGLQELKRRRGPASSHCQLAHSSSNTVSEDGPQAVSSGHRCENKAGTAPGQTLAPRGGSPRSQASRPHINSALYVEDKAISDCRPSRPSHTLSSLATGASGGPPVSKAPTMDAQQDRPKSQDCLGLVAPLASAAEVPSTAPVSGKKHRPPGPLFSSSDPLPATSSHSRDSAQVTSLIPATFTAASRDAGMRR"],[642,866,"AQRSEVRYNQRSQTSRTRSCLKRNASSSSHSSTEGLQELKRRRGPASSHCQLAHSSSNTVSEDGPQAVSSGHRCENKAGTAPGQTLAPRGGYPRSQASRPRINSALHVEDKAISDCRPSRPSHTLSSLATGASGGPPVSKAPTMDAQQDRPKSQDCLGLLAPLASAAEVSSTAPVSGKKHRPPGPLFSSSDPLPATSSHSGDSAQDTSLIPAPFTPASRDAGIRR"]]}],"s":"MPEQDKDPRVQENPDDQRTVPEVTGDARSAFWPLRDNGGPSPFVPRPGPLQTDLHAQSSEIRYNHTSQTSWTSSSTKRNAISSSYSSTGGLPGLKQRRGPASSRCQLTLSYSKTVSEDRPQAVSSGHTRCEKGADTAPGQTIAPTGGSPRSQDSRPRRRKIPLLPRRRGEPLMLPPPLELGYRVTAEDLHLEKETAFQRINSALHVEDKAIPDCRPSRPSHTLSSLATGASGGPPVSKAPTMDAQQDRPKSQDSLGLLAPLASAAEVPSTAPVSGKKHRPPGPLFSSSDPLPATSYHSRDTAQVTSLIPATFTAASRDAGMRRTRSAPAAATAAPPPSTLNNTSGSLLNAVDGGPSHFLASATAAARAQRSEVRYNQRSQTSRTRSCLKRNASSSSSSHSSTEGLQELKRRRGPASSHCQLAHSSSNTVSEDGPQAVSSGHRCENKAGTAPGQTLAPRGGSPRSQASRPHINSALYVEDKAISDCRPSRPSHTLSSLATGASGGPPVSKAPTMDAQQDRPKSQDCLGLVAPLASAAEVPSTAPVSGKKHRPPGPLFSSSDPLPATSSHSRDSAQVTSLIPATFTAASRDAGMRRTRPGTSAPAAAAAALPPSTLNPTSGSLLNAVDGGPSHFLASATAAARAQRSEVRYNQRSQTSRTRSCLKRNASSSSHSSTEGLQELKRRRGPASSHCQLAHSSSNTVSEDGPQAVSSGHRCENKAGTAPGQTLAPRGGYPRSQASRPRINSALHVEDKAISDCRPSRPSHTLSSLATGASGGPPVSKAPTMDAQQDRPKSQDCLGLLAPLASAAEVSSTAPVSGKKHRPPGPLFSSSDPLPATSSHSGDSAQDTSLIPAPFTPASRDAGIRRMFRVRNCLRGLGLFLLVFSFFFLLTWASFSF"},{"id":"SEQ_07838","a":"Q9BY12","g":"SCAPER","d":"S phase cyclin A-associated protein in the endoplasmic reticulum","L":1400,"m":[{"c":"ψxxxxxx[GSC][LV][LIT]xxxxxxxxxφx","u":21,"sp":"dispersed","x":"structured_like","cf":"high","why":"Seven 21-aa alpha-solenoid (Armadillo/HEAT-like) core helices across the C-terminal domain (residues 950-1354) anchored by a conserved central [GSC][LV][LIT] motif (predominantly GLL/GVL/SLL), N-terminal aliphatic anchor, amphipathic hydrophobic register, and frequent His at position 11 and C-terminal Thr at position 21.","i":[[952,972,"IAFQAAGGLTALEHILQAVVP"],[1045,1065,"VFEGLTTGLLKVSAVVLGCLI"],[1103,1123,"ISYVVNMGLIDKLCACFLSVQ"],[1134,1154,"IFLQHAAGLLHAMCTLCFAVT"],[1175,1195,"LQATDLAGVLHMLYCVLFHGT"],[1258,1278,"CSQVSCESLLHEVIVCVGYFT"],[1334,1354,"ILEQEMSCVLLATFIQDLAQT"]]}],"s":"MMASFQRSNSHDKVRRIVAEEGRTARNLIAWSVPLESKDDDGKPKCQTGGKSKRTIQGTHKTTKQSTAVDCKITSSTTGDKHFDKSPTKTRHPRKIDLRARYWAFLFDNLRRAVDEIYVTCESDQSVVECKEVLMMLDNYVRDFKALIDWIQLQEKLEKTDAQSRPTSLAWEVKKMSPGRHVIPSPSTDRINVTSNARRSLNFGGSTGTVPAPRLAPTGVSWADKVKAHHTGSTASSEITPAQSCPPMTVQKASRKNERKDAEGWETVQRGRPIRSRSTAVMPKVSLATEATRSKDDSDKENVCLLPDESIQKGQFVGDGTSNTIESHPKDSLHSCDHPLAEKTQFTVSTLDDVKNSGSIRDNYVRTSEISAVHIDTECVSVMLQAGTPPLQVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQVQVQDSGSWANNKVSALDRTLGEITRILEKENVADQIAFQAAGGLTALEHILQAVVPATNVNTVLRIPPKSLCNAINVYNLTCNNCSENCSDVLFSNKITFLMDLLIHQLTVYVPDENNTILGRNTNKQVFEGLTTGLLKVSAVVLGCLIANRPDGNCQPATPKIPTQEMKNKPSQGDPFNNRVQDLISYVVNMGLIDKLCACFLSVQGPVDENPKMAIFLQHAAGLLHAMCTLCFAVTGRSYSIFDNNRQDPTGLTAALQATDLAGVLHMLYCVLFHGTILDPSTASPKENYTQNTIQVAIQSLRFFNSFAALHLPAFQSIVGAEGLSLAFRHMASSLLGHCSQVSCESLLHEVIVCVGYFTVNHPDNQVIVQSGRHPTVLQKLCQLPFQYFSDPRLIKVLFPSLIAACYNNHQNKIILEQEMSCVLLATFIQDLAQTPGQAENQPYQPKGKCLGSQDYLELANRFPQQAWEEARQFFLKKEKK"},{"id":"SEQ_07839","a":"Q6ZUM4","g":"ARHGAP27","d":"Rho GTPase-activating protein 27","L":889,"m":[{"c":"W(x){8,9}+[PV][FY][FY]YNPx[TD][GS]x[TV]xWEx[PE]","u":"26-27","sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed 26-27 aa repeats anchored by an N-terminal W, a central +[PV][FY][FY]YNP aromatic-proline turn motif, and a C-terminal WEx[PE] signature separated by proline/serine-rich linkers.","i":[[252,278,"WETHTDAGTGRPYYYNPDTGVTTWESP"],[305,331,"WGQYWDEESRRVFFYNPLTGETAWEDE"],[417,442,"WVRLEDPHGKPYFYNPEDSSVRWELP"]]}],"s":"MAADVVGDVYVLVEHPFEYTGKDGRRVAIRPNERYRLLRRSTEHWWHVRREPGGRPFYLPAQYVRELPALGNPAAAAPPGPHPSPAAPEPLAYDYRFVSAAATAGPDGAPEESGGRASSLCGPAQRGAATQRSSLAPGLPACLYLRPAAPVRPAQSLNDLACAAVSPPAGLLGSSGSFKACSVAGSWVCPRPLARSDSENVYEVIQDLHVPPPEESAEQVDDPPEPVYANIERQPRATSPGAAAAPLPSPVWETHTDAGTGRPYYYNPDTGVTTWESPFEAAEGAASPATSPASVDSHVSLETEWGQYWDEESRRVFFYNPLTGETAWEDEAENEPEEELEMQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYNPEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH"},{"id":"SEQ_07840","a":"Q8TF05","g":"PPP4R1","d":"Serine/threonine-protein phosphatase 4 regulatory subunit 1","L":950,"m":[{"c":"ψxxxφxxφxxD(x){3,5}VRxxxxxxφxxxxxxx","u":"30-32","sp":"dispersed","x":"structured_like","cf":"high","why":"Nine canonical 30-32 aa amphipathic helix-turn-helix repeats split across N-terminal and C-terminal helical arrays separated by a central disordered linker, defined by phased hydrophobic positions (ψ1, φ5, φ8), an invariant D11, a conserved VR inter-helical turn, and a conserved hydrophobic anchor 7 residues after VR.","i":[[87,117,"VLERISRLADDSEPTVRAELMEQVPHIALFC"],[132,162,"LLPIVVRYLADQNNQVRKTSQAALLALLEQE"],[213,244,"ILPRFCEMCCDCRMFHVRKVCAANFGDICSVV"],[253,283,"LLPRFFQLCSDNVWGVRKACAECFMAVSCAT"],[292,322,"LSALFINLISDPSRWVRQAAFQSLGPFISTF"],[664,694,"LRETYETLASDMQWKVRRTLAFSIHELAVIL"],[703,732,"LVPIFNGFLKDLDEVRIGVLKHLHDFLKLL"],[782,812,"LRPIALNLCADKVSSVRWISYKLVSEMVKKL"],[866,896,"LMPHLLTLANDRVPNVRVLLAKTLRQTLLEK"]]}],"s":"MADLSLLQEDLQEDADGFGVDDYSSESDVIIIPSALDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIELTAPDSNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQVRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEIDLDIELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLDAHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQDVVPQALLDQYLSMTDPSRAQTVDTEIAKHCAYSLPGVALTLGRQNWHCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELVENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTLRQTLLEKDYFLASASCHQEAVEQTIMALQMDRDSDVKYFASIHPASTKISEDAMSTASSTY"},{"id":"SEQ_07843","a":"Q86TM6","g":"SYVN1","d":"E3 ubiquitin-protein ligase synoviolin","L":617,"m":[{"c":"x[PAL]φPP","u":5,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Seven non-overlapping copies of a 5-residue proline-hydrophobic motif occur across two proline-rich disordered clusters (residues 375-393 and 454-478), anchored by a conserved bulky hydrophobic/aromatic residue (F, W, L, or V) preceding an invariant PP dyad and predominantly P at position 2.","i":[[375,379,"PPFPP"],[383,387,"PLWPP"],[389,393,"GPFPP"],[454,458,"FPFPP"],[463,467,"MPLPP"],[469,473,"FAFPP"],[474,478,"MPVPP"]]}],"s":"MFRTAVMMAASLALTGAVVAHAYYLKHQFYPTVVYLTKSSPSMAVLYIQAFVLVFLLGKVMGKVFFGQLRAAEMEHLLERSWYAVTETCLAFTVFRDDFSPRFVALFTLLLFLKCFHWLAEDRVDFMERSPNISWLFHCRIVSLMFLLGILDFLFVSHAYHSILTRGASVQLVFGFEYAILMTMVLTIFIKYVLHSVDLQSENPWDNKAVYMLYTELFTGFIKVLLYMAFMTIMIKVHTFPLFAIRPMYLAMRQFKKAVTDAIMSRRAIRNMNTLYPDATPEELQAMDNVCIICREEMVTGAKRLPCNHIFHTSCLRSWFQRQQTCPTCRMDVLRASLPAQSPPPPEPADQGPPPAPHPPPLLPQPPNFPQGLLPPFPPGMFPLWPPMGPFPPVPPPPSSGEAVAPPSTSAAALSRPSGAATTTAAGTSATAASATASGPGSGSAPEAGPAPGFPFPPPWMGMPLPPPFAFPPMPVPPAGFAGLTPEELRALEGHERQHLEARLQSLRNIHTLLDAAMLQINQYLTVLASLGPPRPATSVNSTEETATTVVAAASSTSIPSSEATTPTPGASPPAPEMERPPAPESVGTEEMPEDGEPDAAELRRRRLQKLESPVAH"},{"id":"SEQ_07863","a":"Q9Y219","g":"JAG2","d":"Protein jagged-2","L":1238,"m":[{"c":"C(x){3,5}C(x){2,4}GxC(x){3,7}ΩxCxCPxGΩxGxxC","u":"29-34","sp":"periodic","x":"structured_like","cf":"high","why":"Fifteen 29-34 aa six-cysteine repeats occur with regular ~6 aa inter-unit linkers (interrupted once by an insertion-bearing divergent copy), anchored by six invariant cysteines including a fixed CxC pair and a conserved C-terminal PxGΩxGxxC motif.","i":[[245,273,"CKQGCNLLHGGCTVPGECRCSYGWQGRFC"],[276,304,"CVPYPGCVHGSCVEPWQCNCETNWGGLLC"],[311,344,"CGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNC"],[351,382,"CTSNPCANGGSCHEVPSGFECHCPSGWSGPTC"],[389,420,"CASNPCAAGGTCVDQVDGFECICPEQWVGATC"],[427,458,"CEGKPCLNAFSCKNLIGGYYCDCIPGWKGINC"],[465,495,"CRGQCQHGGTCKDLVNGYQCVCPRGFGGRHC"],[502,533,"CASSPCHSGGLCEDLADGFHCHCPQGFSGPLC"],[540,571,"CEPSPCRNGARCYNLEGDYYCACPDDFGGKNC"],[640,671,"CLGQPCRNGGTCIDEVDAFRCFCPSGWEGELC"],[678,709,"CLPDPCHSRGRCYDLVNDFYCACDDGWKGKTC"],[716,747,"CDAYTCSNGGTCYDSGDTFRCACPPGWKGSTC"],[755,786,"CLPNPCVNGGTCVGSGASFSCICRDGWEGRTC"],[793,824,"CNPLPCYNGGICVDGVNWFRCECAPGFAGPDC"],[831,862,"CQSSPCAYGATCVDEINGYRCSCPPGRAGPRC"]]}],"s":"MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSSTGLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRNPIERPGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHKFTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE"},{"id":"SEQ_07864","a":"O00221","g":"NFKBIE","d":"NF-kappa-B inhibitor epsilon","L":500,"m":[{"c":"GxTxψHψAx(x){9,12}LLxxGA(x){8,19}","u":"33-43","sp":"tandem","x":"structured_like","cf":"high","why":"Six contiguous head-to-tail tandem repeats of 33-35 aa (with one 43 aa copy containing an internal proline/glycine-rich loop insertion), anchored by an invariant HψA core within an N-terminal GxTxψHψA motif, a central hydrophobic doublet, and a conserved GA turn.","i":[[259,293,"GDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNL"],[294,326,"YQTALHLAVHLDQPGAVRALVLKGASRALQDRH"],[327,369,"GDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQ"],[370,403,"GLACLHIATLQKNQPLMELLLRNGADIDVQEGTS"],[404,436,"GKTALHLAVETQERGLVQFLLQAGAQVDARMLN"],[437,469,"GCTPLHLAAGRGLMGISSTLCKAGADSLLRNVE"]]}],"s":"MNQRRSESRPGNHRLQAYAEPGKGDSGGAGPLSGSARRGRGGGGAIRVRRPCWSGGAGRGGGPAWAVRLPTVTAGWTWPALRTLSSLRAGPSEPHSPGRRPPRAGRPLCQADPQPGKAARRSLEPDPAQTGPRPARAAGMSEARKGPDEAEESQYDSGIESLRSLRSLPESTSAPASGPSDGSPQPCTHPPGPVKEPQEKEDADGERADSTYGSSSLTYTLSLLGGPEAEDPAPRLPLPHVGALSPQQLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDLTEESLVLLPFDDLKISGKLLLCTD"},{"id":"SEQ_07873","a":"Q53EL6","g":"PDCD4","d":"Programmed cell death protein 4","L":469,"m":[{"c":"φxKxxψxxψxEYφxxGDxoEφxExL+-Lxψ[GP]xφxxxψxφxAψxψφLE[GS](x){2,5}ExTxKψψxDL","u":"60-63","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of a 60-63 aa multi-helical domain segment sharing 16 identical anchor positions (including EY, GD, L+-L, A...LE, and ExTxK...DL) and 17 physicochemically conserved core/turn positions across a minor 2-5 aa loop variation.","i":[[164,226,"FEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDL"],[327,386,"LVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDL"]]}],"s":"MDVENEQILNVNPADPDNLSDSLFSGDEENAGTEEIKNEINGNWISASSINEARINAKAKRRLRKNSSRDSGRGDSVSDSGSDALRSGLTVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSRGRKRFVSEGDGGRLKPESY"},{"id":"SEQ_07875","a":"P34810","g":"CD68","d":"Macrosialin","L":354,"m":[{"c":"[HNS][PR][AT]T[KT]SH[GK][NT][ATV]T(x){0,1}H[PR]T[ST][NT][ST][GT][AT]TS[HQP]G[FP][ST][ST][AS][AT]H","u":"29-30","sp":"tandem","x":"disordered_like","cf":"high","why":"Three head-to-tail tandem 29-30 aa repeats in the N-terminal S/T/P-rich disordered region anchored by invariant SH, H, and S[HQP]G...H motifs (with copies 2 and 3 sharing >80% identity).","i":[[51,79,"HRTTKSHKTTTHRTTTTGTTSHGPTTATH"],[80,109,"NPTTTSHGNVTVHPTSNSTATSQGPSTATH"],[110,139,"SPATTSHGNATVHPTSNSTATSPGFTSSAH"]]},{"c":"[LF]GQSFSC[SP]oxxxIL[SL]P","u":16,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two non-overlapping 16-aa extracellular/juxtamembrane repeats separated by a 21-aa linker and strongly conserved at 9 identical anchor residues including an invariant GQSFSC hexapeptide and C-terminal ILxP motif.","i":[[271,286,"LGQSFSCSNSSIILSP"],[308,323,"FGQSFSCPSDRSILLP"]]}],"s":"MRLAVLFSGALLGLLAAQGTGNDCPHKKSATLLPSFTVTPTVTESTGTTSHRTTKSHKTTTHRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSNSTATSQGPSTATHSPATTSHGNATVHPTSNSTATSPGFTSSAHPEPPPPSPSPSPTSKETIGDYTWTNGSQPCVHLQAQIQIRVMYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQKVVYLSYMAVEYNVSFPHAAQWTFSAQNASLRDLQAPLGQSFSCSNSSIILSPAVHLDLLSLRLQAAQLPHTGVFGQSFSCPSDRSILLPLIIGLILLGLLALVLIAFCIIRRRPSAYQAL"},{"id":"SEQ_07895","a":"Q96J02","g":"ITCH","d":"E3 ubiquitin-protein ligase Itchy homolog","L":903,"m":[{"c":"PLP[PE]GWExRx[DT]xxG[RI]xYΩV[DN]Hxx+xT[TQ]Ωx[RD]P","u":31,"sp":"dispersed","x":"structured_like","cf":"high","why":"Four strongly conserved 31-aa structured repeat units in the central region anchored by invariant PLP, GWE, R, G, YΩV, H, T, Ω, and C-terminal P positions, separated by variable linkers (1, 49, and 9 aa).","i":[[327,357,"PLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP"],[359,389,"PLPPGWERRVDNMGRIYYVDHFTRTTTWQRP"],[439,469,"PLPPGWEKRTDSNGRVYFVNHNTRITQWEDP"],[479,509,"PLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP"]]}],"s":"MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNTNSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSENGVSLCLPRLECNSAISAHCNLCLPGLSDSPISASRVAGFTGASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE"},{"id":"SEQ_07901","a":"A6NE01","g":"FAM186A","d":"Protein FAM186A","L":2351,"m":[{"c":"Gψ[PT][LF]TPQQAQ[AE]L","u":12,"sp":"tandem","x":"disordered_like","cf":"high","why":"Contiguous 48-copy head-to-tail tandem array of highly conserved 12-residue units (residues 1072-1647) anchored by G at position 1, aliphatic ψ at position 2, hydrophobic [LF] at position 4, a near-invariant TPQQAQ core, and [AE]L at positions 11-12.","i":[[1072,1083,"CIHLTPQQAQEV"],[1084,1095,"GITLTPQQAQAQ"],[1096,1107,"GITLTLQQAQEL"],[1108,1119,"GIPLTPQQAQAL"],[1120,1131,"EILFTPQQAQAL"],[1132,1143,"GIPLTPQQTQVQ"],[1144,1155,"GITLTPQQDQAP"],[1156,1167,"GISLTTQQAQKL"],[1168,1179,"GIPLTPQQAQAL"],[1180,1191,"GIPLTPQQAQEL"],[1192,1203,"GIPLTPQQAQAL"],[1204,1215,"RVSLTPQQAQEL"],[1216,1227,"GIPLTPQQAQAL"],[1228,1239,"GITLTLQQAQQL"],[1240,1251,"GIPLTPQQAQAL"],[1252,1263,"GITLTPKQVQEL"],[1264,1275,"GIPLTPQQAQAL"],[1276,1287,"GITLTPKQAQEL"],[1288,1299,"GIPLNPQQAQTL"],[1300,1311,"GIPLTPKQAQAL"],[1312,1323,"GIPFTPQQAQAL"],[1324,1335,"GIPLTPQQAQTQ"],[1336,1347,"EITLTPQQAQAL"],[1348,1359,"GMPLTTQQAQEL"],[1360,1371,"GIPLTPQHAQAL"],[1372,1383,"GMPLTTQQAQEL"],[1384,1395,"GIPLTPQQAQAL"],[1396,1407,"GMPLTTQQAQEL"],[1408,1419,"GIPLTPQQAQEL"],[1420,1431,"GIPFTPQQAQAQ"],[1432,1443,"EITLTPQQAQAL"],[1444,1455,"GMPLTAQQAQEL"],[1456,1467,"GITLTPQQAQEL"],[1468,1479,"GIPLTPQQAQAL"],[1480,1491,"GIPLIPPQAQEL"],[1492,1503,"GIPLTPQQAQAL"],[1504,1515,"GILLIPPQAQEL"],[1516,1527,"GIPLTPQQAQAL"],[1528,1539,"GIPLIPPQAQEL"],[1540,1551,"GIPLTPQQVQAL"],[1552,1563,"GIPLIPPQAQEL"],[1564,1575,"EIPLTPQQAQAL"],[1576,1587,"GIPLTPQQAQEL"],[1588,1599,"GIPLTPQQAQEL"],[1600,1611,"GIPLTPQQAQAQ"],[1612,1623,"GIPLTPQQAQAL"],[1624,1635,"GISLTPQQAQAQ"],[1636,1647,"GITLTPQQAQAL"]]},{"c":"xx[PLS]x[STA][PS]G[QK]x[LPF]xx","u":12,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Distinct C-terminal proline-rich 12-residue repeat family (residues 1769-1946) occurring in tandem clusters separated by diverged 12-mer/10-mer linker units, anchored by an invariant G at position 7 within a conserved [PS]G[QK] core and flanking proline/hydrophobic positions.","i":[[1769,1780,"QGPFAPGKPLEM"],[1781,1792,"GILSEPGKLGAP"],[1793,1804,"QTLRSSGQTLVY"],[1817,1828,"QAPPSPGQLPIS"],[1829,1840,"RAPPTPGQPFIA"],[1841,1852,"GVPPTSGQIPSL"],[1853,1864,"WAPLSPGQPLVP"],[1901,1912,"QAPSTPGQHLAT"],[1935,1946,"WPSPAPGKPQKS"]]}],"s":"MFFKMKNEIDNDPESEKCIKDSTIMRREPQNILSPLMLPNLEIPFSVKDIISRIERAQLHRAREDIDMQLSEIMNNVHRIMTRYTLVFNSSSERNVSLTEHKKKQRTNFLEKMATYAKTIEIREKTLANILAWLEEWNDVLSEMTLMDVDEHHHWIAQMELLPDTLKAIENNVKILSRFSTSFLDEKKKQKKKILSRGTLWKSWKERVIKRPSTARALRPDQMISDQLATNTKVSEIQGMLQELIGTTMFSTLENNAIKYISSTIVNLSTALSMLNDELKCVNFQSSTVYAHETSEAEKELSLKIIRDLSNENEMLQQKLQDAEEKCEQLIRSKIVIEQLYAKLSTSSTLKVLPGPSPQSSRAIIKVGDTEDNMDNILDKELENIVDEVQRKETKDSGIKWDSTISYTAQAERTPDLTELRQQPVASEDISEDSTKDNVSLKKGDFYQEDETDEYQSWKRSHKKATYVYETSGPNLSDNKSGQKVSEAKPSQYYELQVLKKKRKEMKSFSEDKSKSPTEAKRKHLSLTETKSQGGKSGTSMMMLEQFRKVKRESPFDKRPTAAEIKVEPTTESLDKEGKGEIRSLVEPLSMIQFDDTAEPQKGKIKGKKHHISSGTITSKEEKTEEKEELTKQVKSHQLVKSLSRVAKETSESTRVLESPDGKSEQSNLEEFQEAIMAFLKQKIDNIGKAFDKKTVPKEEELLKRAEAEKLGIIKAKMEEYFQKVAETVTKILRKYKDTKKEEQVGEKPIKQKKVVSFMPGLHFQKSPISAKSESSTLLSYESTDPVINNLIQMILAEIESERDIPTVSTVQKDHKEKEKQRQEQYLQEGQEQMSGMSLKQQLLGERNLLKEHYEKISENWEEKKAWLQMKEGKQEQQSQKQWQEEEMWKEEQKQATPKQAEQEEKQKQRGQEEEELPKSSLQRLEEGTQKMKTQGLLLEKENGQMRQIQKEAKHLGPHRRREKGKEKQKPERGLEDLERQIKTKDQMQMKETQPKELEKMVIQTPMTLSPRWKSVLKDVQRSYEGKEFQRNLKTLENLPDEKEPISITPPPSLQYSLPGALPISGQPLTKCIHLTPQQAQEVGITLTPQQAQAQGITLTLQQAQELGIPLTPQQAQALEILFTPQQAQALGIPLTPQQTQVQGITLTPQQDQAPGISLTTQQAQKLGIPLTPQQAQALGIPLTPQQAQELGIPLTPQQAQALRVSLTPQQAQELGIPLTPQQAQALGITLTLQQAQQLGIPLTPQQAQALGITLTPKQVQELGIPLTPQQAQALGITLTPKQAQELGIPLNPQQAQTLGIPLTPKQAQALGIPFTPQQAQALGIPLTPQQAQTQEITLTPQQAQALGMPLTTQQAQELGIPLTPQHAQALGMPLTTQQAQELGIPLTPQQAQALGMPLTTQQAQELGIPLTPQQAQELGIPFTPQQAQAQEITLTPQQAQALGMPLTAQQAQELGITLTPQQAQELGIPLTPQQAQALGIPLIPPQAQELGIPLTPQQAQALGILLIPPQAQELGIPLTPQQAQALGIPLIPPQAQELGIPLTPQQVQALGIPLIPPQAQELEIPLTPQQAQALGIPLTPQQAQELGIPLTPQQAQELGIPLTPQQAQAQGIPLTPQQAQALGISLTPQQAQAQGITLTPQQAQALGVPITPVNAWVSAVTLTSEQTHALESPMNLEQAQEQLLKLGVPLTLDKAHTLGSPLTLKQVQWSHRPFQKSKASLPTGQSIISRLSPSLRLSLASSAPTAEKSSIFGVSSTPLQISRVPLNQGPFAPGKPLEMGILSEPGKLGAPQTLRSSGQTLVYGGQSTSAQFPAPQAPPSPGQLPISRAPPTPGQPFIAGVPPTSGQIPSLWAPLSPGQPLVPEASSIPGDLLESGPLTFSEQLQEFQPPATAEQSPYLQAPSTPGQHLATWTLPGRASSLWIPPTSRHPPTLWPSPAPGKPQKSWSPSVAKKRLAIISSLKSKSVLIHPSAPDFKVAQVPFTTKKFQMSEVSDTSEETQILRDTFAIESFRTFQSHFTKYRTPVYQTPYTDERALLTLMKPTTSPSSLTTLLRTSQISPLEWYQKSRFPPIDKPWILSSVSDTKKPKVMVPPSSPQELEEKRYFVDVEAQKKNLILLNQAIKTCGLPSQLHTMARTLIIEILHMDTVQLGYLFRKYIAYRLIQHARNNIMKRLKAIQNTGKGYEARNLHMMLSRLDDYGKKVMQVWTEKQKSLGQKRNQCLKKMIHVFNQLKKIHELNLSQPIPLIIEEKQIPASTTFVQKPFLKLLMEEDRTSDICKKFRQQEDQTEAIWNVDLSTSSYPIAEKTSMHSLWAQLGGYPDIPRLLQLEVQSTFRKSLASLQSRVKKIPK"},{"id":"SEQ_07905","a":"Q9P227","g":"ARHGAP23","d":"Rho GTPase-activating protein 23","L":1491,"m":[{"c":"LxS-PR[ST]PxAΩx-PGxRVPP","u":20,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Internal 20-residue duplication in the proline/serine-rich disordered region sharing 12 identical anchors (L, S, P, R, A, G, V) and 4 conservative acidic/polar/aromatic positions (D/E, S/T, W/F) separated by a 24-aa linker.","i":[[215,234,"LPSDPRSPAAWSDPGLRVPP"],[260,279,"LSSEPRTPRAFPEPGSRVPP"]]}],"s":"MNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRHFIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATRSAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDPGSDSTTCSSAKSKGSWAPKKEPYAREMLAISFISAVNRKRKKRREARGLGSSTDDDSEQEAHKPGAGATAPGTQERPQGPLPGAVAPEAPGRLSPPAAPEERPAADTRSIVSGYSTLSTMDRSVCSGASGRRAGAGDEADDERSELSHVETDTEGAAGAGPGGRLTRRPSFSSHHLMPCDTLARRRLARGRPDGEGAGRGGPRAPEPPGSASSSSQESLRPPAAALASRPSRMEALRLRLRGTADDMLAVRLRRPLSPETRRRRSSWRRHTVVVQSPLTDLNFNEWKELGGGGPPEPAGARAHSDNKDSGLSSLESTKARAPSSAASQPPAPGDTGSLQSQPPRRSAASRLHQCL"},{"id":"SEQ_07907","a":"Q8TD94","g":"KLF14","d":"Krueppel-like factor 14","L":323,"m":[{"c":"[HF][QS]C(x){2,4}CxKxΩx+S[SD][HE]LxxHxR[TR]H","u":"23-25","sp":"periodic","x":"structured_like","cf":"high","why":"Three periodic 23-25 aa CxxC/CxxxxC...HxxxH repeats anchored by invariant Cys pairs, conserved K, aromatic (Y/F), basic, S, L, R, and His pairs, separated by regular 5-aa TGE[RK][PR] linkers.","i":[[195,219,"HQCPFPGCTKAYYKSSHLKSHQRTH"],[225,249,"FSCDWLDCDKKFTRSDELARHYRTH"],[255,277,"FSCPLCPKQFSRSDHLTKHARRH"]]}],"s":"MSAAVACLDYFAAECLVSMSAGAVVHRRPPDPEGAGGAAGSEVGAAPPESALPGPGPPGPASVPQLPQVPAPSPGAGGAAPHLLAASVWADLRGSSGEGSWENSGEAPRASSGFSDPIPCSVQTPCSELAPASGAAAVCAPESSSDAPAVPSAPAAPGAPAASGGFSGGALGAGPAPAADQAPRRRSVTPAAKRHQCPFPGCTKAYYKSSHLKSHQRTHTGERPFSCDWLDCDKKFTRSDELARHYRTHTGEKRFSCPLCPKQFSRSDHLTKHARRHPTYHPDMIEYRGRRRTPRIDPPLTSEVESSASGSGPGPAPSFTTCL"},{"id":"SEQ_07913","a":"Q6BDS2","g":"BLTP3A","d":"Bridge-like lipid transfer protein family member 3A","L":1440,"m":[{"c":"TK-Aφ[HS][AL]","u":7,"sp":"dispersed","x":"mixed","cf":"high","why":"Three tightly conserved 7-aa repeats in a local amphipathic island within the central disordered region (preceded immediately by a partial TKDA cap), anchored by invariant T1, K2, and A4, acidic [DE]3, bulky hydrophobic φ5 (L/V/F), and constrained C-terminal [HS][AL]; copies 2 and 3 are head-to-tail while copy 1 is separated by a 4-aa linker (TMDL).","i":[[1029,1035,"TKEALHA"],[1040,1046,"TKEAVSL"],[1047,1053,"TKDAFSL"]]},{"c":"[QT]GSP[LA]xNo","u":8,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three 8-aa motifs within the Ser/Pro-rich disordered region (one N-proximal copy and a near-tandem C-proximal pair separated by YG) sharing an invariant GSP core and N7 anchor flanked by polar [QT]1, small/aliphatic [LA]5, and C-terminal polar o8.","i":[[860,867,"TGSPLQNQ"],[1159,1166,"QGSPLVNN"],[1169,1176,"QGSPAANS"]]}],"s":"MAGIIKKQILKHLSRFTKNLSPDKINLSTLKGEGQLTNLELDEEVLQNVLELPTWLAITRVYCNRASIRIQWTKLKTHPICLCLDKVEVEMKTCEDPRPPNGQSPIALASGQSEYGFAEKVVEGMFIIVNSITIKIHSKAFHASFELWQLQGYSVNPNWQQSDLRLTRITDPCRGEVLTFKEITWQTLRIEADATDNGDQDPVTTPLRLITNQGRIQIALKRRTKDCNVISSKLMFLLDDLLWVLTDSQLKAMMKYAESLSEAMEKSAHQRKSLAPEPVQITPPAPSAQQSWAQAFGGSQGNSNSSSSRLSQYFEKFDVKESSYHLLISRLDLHICDDSQSREPGVSANRLMGGAMQLTFRKMAFDYYPFHWAGDSCKHWVRHCEAMETRGQWAQKLVMEFQSKMEKWHEETGLKPPWHLGVDSLFRRKADSLSSPRKNPLERSPSQGRQPAFQPPAWNRLRSSCMVVRVDDLDIHQVSTAGQPSKKPSTLLSCSRKLHNLPTQVSAIHIEFTEYYFPDNQELPVPCPNLYIQLNGLTFTMDPVSLLWGNLFCLDLYRSLEQFKAIYKLEDSSQKDEHLDIRLDAFWLKVSFPLEKRERAELHRPQALVFSASGMIATNTRHAPHCSCSDLQSLFRGFAAAEFFHSNYDHFPKVPGGFSLLHMLFLHHAFQMDSCLPQPNTLPPQRPKASWDLWSVHFTQISLDFEGTENFKGHTLNFVAPFPLSIWACLPLRWQQAQARKLLLASEGRLKPSASFGSPVQSEALAPDSMSHPRSKTEHDLKSLSGLTEVMEILKEGSSGMDNKGPLTELEDVADVHMLVHSPAHVRVRLDHYQYLALLRLKEVLQRLQEQLTKDTESMTGSPLQNQTACIGVLFPSAEVALLMHPAPGAVDADSAGSDSTSLVDSELSPSEDRELKSDASSDQGPASPEKVLEESSIENQDVSQERPHSNGELQDSGPLAQQLAGKGHEAVESLQAKKLSRTQASSSPAALKPPAGRETAVNGQGELIPLKNIEGELSSAIHMTKDATKEALHATMDLTKEAVSLTKDAFSLGRDRMTSTMHKMLSLPPAKEPMAKTDEGVAAPVSGGAARLRFFSMKRTVSQQSFDGVSLDSSGPEDRISVDSDGSDSFVMLLESESGPESVPPGSLSNVSDNAGVQGSPLVNNYGQGSPAANSSVSPSGEDLIFHPVSVLVLKVNEVSFGIEVRGEDLTVALQAEELTLQQLGTVGLWQFLHGQCPGTCFQESSTLKTGHIRPAVGLRFEVGPGAAVHSPLASQNGFLHLLLHGCDLELLTSVLSGLGPFLEDEEIPVVVPMQIELLNSSITLKDDIPPIYPTSPGPIPITLAMEHVVLKRSDDGVFHIGAAAQDKPSAEVLKSEKRQPPKEQVFLVPTGEVFEQQVKELPILQKELIETKQALANANQDKEKLLQEIRKYNPFFEL"},{"id":"SEQ_07916","a":"Q58EX2","g":"SDK2","d":"Protein sidekick-2","L":2172,"m":[{"c":"P(x){1,4}P(x){13,17}φx[WF](x){12,16}Ωxψ(x){33,55}Yxφxψxxφ[NT]xx[GY]x[GSP](x){9,13}","u":"93-118","sp":"tandem","x":"structured_like","cf":"high","why":"Thirteen tandem ~93-118 aa structured repeats spanning residues 593-1918, anchored by an N-terminal P-x(1,4)-P cap, conserved φx[WF] and Ωxψ core motifs, and a C-terminal Yx[φT]xψxxx[NT]xx[GY]x[GSP] signature separated by 2-5 aa linkers.","i":[[593,685,"PEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSL"],[690,787,"PTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTL"],[791,891,"PTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTH"],[895,988,"PGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGV"],[993,1092,"PGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTL"],[1095,1196,"PPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRE"],[1199,1296,"PSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERT"],[1301,1397,"PGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKR"],[1400,1497,"PQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTL"],[1501,1618,"PDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFV"],[1623,1719,"PTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQT"],[1724,1819,"PSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTG"],[1825,1918,"PGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSV"]]},{"c":"(x){14,15}φx[CF](x){6,13}W(x){15,24}[LY]xIxxxxxx[DH]xGx[YF]x[CV](x){18,21}","u":"80-87","sp":"dispersed","x":"structured_like","cf":"high","why":"Six N-terminal ~80-87 aa structured repeats (residues 32-587, separated by 7-16 aa linkers) defined by an invariant W, a conserved [LY]xIxxxxxx[DH]xGx[YF]x[CV] signature, and paired cysteines in five of the six copies (substituted by F/V in the second copy).","i":[[32,111,"PVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAY"],[124,203,"VSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTV"],[220,305,"PPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVL"],[314,398,"PERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVT"],[407,493,"GPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVW"],[501,587,"PPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVR"]]}],"s":"MWGLLIWTLLALHQIRAARAQDDVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKANPFYEEWWFLVVIALVGLIFILLLVFVLIIRGQSKKYAKKTDSGNSAKSGALGHSEMMSLDESSFPALELNNRRLSVKNSFCRKNGLYTRSPPRPSPGSLHYSDEDVTKYNDLIPAESSSLTEKPSEISDSQGSDSEYEVDSNHQKAHSFVNHYISDPTYYNSWRRQQKGISRAQAYSYTESDSGEPDHTTVTNSTSTQQGSLFRPKASRTPTPQNPPNPPSQQSTLYRPPSSLAPGSRAPIAGFSSFV"},{"id":"SEQ_07965","a":"Q5SV97","g":"PERM1","d":"PGC-1 and ERR-induced regulator in muscle protein 1","L":790,"m":[{"c":"[MVT]A[VL]S[TI]P[AI]S[EK][PH][QG][PSL][DS]","u":13,"sp":"tandem","x":"disordered_like","cf":"high","why":"Tandem array of 8 central disordered repeats (residues 298-411, separated by 0-2 aa RD/TD linkers) anchored by invariant A2, S4, P6, and S8 positions alongside conserved N-terminal aliphatic and C-terminal [EK]PQxD architecture.","i":[[298,310,"MAVSTPASEPQPD"],[313,325,"MAVSTPASEPQSD"],[328,340,"MAVSTPASEPQPD"],[343,355,"MAVSTPASEPQPD"],[358,370,"MAVSIPASKPQSD"],[371,383,"TAVSTPASEPQSS"],[384,396,"VALSTPISKPQLD"],[399,411,"VAVSTPASKHGLD"]]},{"c":"φP-φ[YC]E[FH]FFx","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed aromatic-acidic motifs in the C-terminal proline/acidic disordered region (residues 580-665) sharing a conserved φP-[ED]-φ-[YC]-E core immediately preceding a tri-phenylalanine cluster (with a single H insertion before FFF in the third copy).","i":[[580,589,"LPEAYEFFFC"],[612,621,"WPDMCEFFFP"],[656,665,"IPEVYEHFFF"]]}],"s":"MENFQYSVQLSDQDWAEFSATADECGLLQAGLASGDELLSSDIDQGDSSGSSPPRAPPLPTGQLAAGGRSRRGCEEEDVATQQPVSRSQGEPVLALGTGQQTPSTSARAEAPPSLGPGASPPSQFSSCPGPASSGDQMQRLLQGPAPRPPGEPPGSPKSPGHSTGSQRPPDSPGAPPRSPSRKKRRAVGAKGGGHTGASASAQTGSPLLPAASPETAKLMAKAGQEELGPGPAGAPEPGPRSPVQEDRPGPGLGLSTPVPVTEQGTDQIRTPRRAKLHTVSTTVWEALPDVSRAKSDMAVSTPASEPQPDRDMAVSTPASEPQSDRDMAVSTPASEPQPDTDMAVSTPASEPQPDRDMAVSIPASKPQSDTAVSTPASEPQSSVALSTPISKPQLDTDVAVSTPASKHGLDVALPTAGPVAKLEVASSPPVSEAVPRMTESSGLVSTPVPRADAAGLAWPPTRRAGPDVVEMEAVVSEPSAGAPGCCSGAPALGLTQVPRKKKVRFSVAGPSPNKPGSGQASARPSAPQTATGAHGGPGAWEAVAVGPRPHQPRILKHLPRPPPSAVTRVGPGSSFAVTLPEAYEFFFCDTIEENEEAEAAAAGQDPAGVQWPDMCEFFFPDVGAQRSRRRGSPEPLPRADPVPAPIPGDPVPISIPEVYEHFFFGEDRLEGVLGPAVPLPLQALEPPRSASEGAGPGTPLKPAVVERLHLALRRAGELRGPVPSFAFSQNDMCLVFVAFATWAVRTSDPHTPDAWKTALLANVGTISAIRYFRRQVGQGRRSHSPSPSS"},{"id":"SEQ_07973","a":"Q15746","g":"MYLK","d":"Myosin light chain kinase, smooth muscle","L":1914,"m":[{"c":"φxx[GN]xxxxφx[CGV]xφx[GS]x[PQ]x[PAI]x[VIC]xW(x){29,33}[DH]x[GA]xYx[CIL]x[AVL]xNxxGxxxxxxxψxψ","u":"76-80","sp":"dispersed","x":"structured_like","cf":"high","why":"Nine dispersed 76-80 aa structured repeats anchored by invariant W, Y, N, and G positions along with conserved cysteines, proline-containing N-terminal segments, and hydrophobic beta-strand cores.","i":[[44,123,"IKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTV"],[172,250,"VKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSI"],[425,504,"VKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQV"],[525,600,"VIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTV"],[634,712,"VMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTV"],[732,811,"ASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLML"],[1109,1187,"VAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTV"],[1249,1327,"VRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTV"],[1820,1899,"VVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIV"]]},{"c":"Pψ[GS]NA[KQ]P[ASD][GE][PTN]LK","u":12,"sp":"tandem","x":"disordered_like","cf":"high","why":"Five head-to-tail tandem 12-aa repeats within the central disordered linker, anchored by invariant P1, N4, A5, P7, L11, and K12 positions including two identical PMGNAKPAETLK copies.","i":[[1013,1024,"PLSNAQPSGPLK"],[1025,1036,"PVGNAKPAETLK"],[1037,1048,"PMGNAKPAETLK"],[1037,1048,"PMGNAKPAETLK"],[1049,1060,"PMGNAKPDENLK"]]},{"c":"[QT]xDFR[DAS][LNV]L[GQA][KRG][KQ]","u":11,"sp":"periodic","x":"disordered_like","cf":"high","why":"Four 11-aa motifs within the central disordered region occurring at an exact 28-residue start-to-start period (17-aa linkers), anchored by an invariant DFRxxL core and flanking polar/basic positions.","i":[[894,904,"QLDFRDLLGKK"],[922,932,"QMDFRANLQRQ"],[950,960,"QVDFRSVLAKK"],[978,988,"TPDFRSVLGGK"]]}],"s":"MGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSANRSFVRETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQEVEQLDFRDLLGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGEGEEEEE"},{"id":"SEQ_07983","a":"A2RUR9","g":"CCDC144A","d":"Coiled-coil domain-containing protein 144A","L":1427,"m":[{"c":"[SY]xG[SYF][PQ][GY][DS][QW]W","u":9,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three head-to-tail 9-aa repeats in the N-terminal disordered tail anchored by invariant G (position 3) and C-terminal W (position 9), with strong internal conservation (GDQW in copies 1-2, YSWW in copy 3, and G[YF]P in copies 2-3).","i":[[28,36,"SVGSQGDQW"],[37,45,"YLGYPGDQW"],[46,54,"SSGFPYSWW"]]},{"c":"-[GS]xxVGN(x){0,2}D[DS]-GLN(x){2,3}IPRK[EK][NR]","u":"21-24","sp":"dispersed","x":"disordered_like","cf":"medium","why":"Two highly conserved 21-24 aa disordered motifs flanking the N- and C-terminal boundaries of the central coiled-coil domain, sharing 11 identical anchor residues (VGN, D, GLN, IPRK) and conserved acidic positions separated by two short variable-length polar linkers.","i":[[547,567,"DGTTVGNDDDGLNQQIPRKEN"],[1331,1354,"ESPCVGNLNDSEGLNRKHIPRKKR"]]}],"s":"MASWGGEKRGGAEGSPKPAVYATRKTPSVGSQGDQWYLGYPGDQWSSGFPYSWWKNSVGSESKHGEGALDQPQHDVRLEDLGELHRAARSGDVPGVEHILAPGDTGVDKRDRKKSIQQLVPEYKEKQTPESLPQNNNPDWHPTNLTLSDETCQRSKNLKVDDKCPSVSPSMPENQSATKELGQMNLTEREKMDTGVVLLSGNDTLHDLCQSQLPENKESKEAEQDSELTSEEEQERLKGCENKQPQKTSQEPEMAKDCDREDIPIYPVLPHVQKSEEMWIEQGKLEWKNQLKLVINELKQRFGEIYEKYKIPACPEEEPLLDNSTRGTDVKDIPFNLTNNIPGCEEEDASEISVSVVFETFPEQKEPSLKNIIHPYYHPYSGSQEHVCQSSSKFHLHENKLDCDNDNKPGIGHIFSTDKNFHNDASTKKARNPEVVMVEMKEDQEFDLQMTKNMNQNSDSGSTNNYKSLKPKLENLSSLPPDSDRTSEVYLHEELQQDMQKFKNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTELSGTLTDGTTVGNDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSKLKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLHLDAENEVLQLQQTLFSMKAIQKQCETLQKNKKQLKQEVVNLKSYMERNMLERGKAEWHKLLIEERARKEIEEKLNEAILTLQKQAAVSHEQLVQLREDNTTSIKTQMELTIKDLESEISRIKTSQADFNKTELERYKELYLEEVKVRESLSNELSRTNEMIAEVSTQLTVEKEQTRSRSLFTAYATRPVLESPCVGNLNDSEGLNRKHIPRKKRSALKDMESYLLKMQQKLQNDLTAEVAGSSQTGLHRIPQCSSFSSSSLHLLLCSICQPFFLILQLLLNMNLDPI"},{"id":"SEQ_07988","a":"Q9P273","g":"TENM3","d":"Teneurin-3","L":2699,"m":[{"c":"C(x){3,4}CxxxGx[CY](x){2,5}G(x){1,2}CxCxx[GN]ΩxGxxC","u":"27-31","sp":"periodic","x":"structured_like","cf":"high","why":"Array of eight cysteine-rich 27-31 aa repeats (pos 521-776) separated by regular 4-6 aa linkers, anchored by five invariant cysteines (plus a sixth C/Y position), three conserved glycines, and a conserved [GN]Ω aromatic motif.","i":[[518,544,"CPRNCHGNGECVSGTCHCFPGFLGPDC"],[549,575,"CPVLCSGNGQYSKGRCLCFSGWKGTEC"],[582,609,"CIDPQCGGRGICIMGSCACNSGYKGESC"],[614,641,"CIDPGCSNHGVCIHGECHCSPGWGGSNC"],[648,676,"CPDQCSGHGTYLQESGSCTCDPNWTGPDC"],[681,707,"CSVDCGSHGVCMGGTCRCEEGWTGPAC"],[712,738,"CHPRCAEHGTCKDGKCECSQGWNGEHC"],[743,773,"CPGLCNSNGRCTLDQNGWHCVCQPGWRGAGC"]]},{"c":"φxYDxx[GD]xψ","u":9,"sp":"dispersed","x":"structured_like","cf":"high","why":"Eight occurrences across the C-terminal beta-shell region (pos 1631-2281, including a tightly spaced ~21-aa periodic cluster at 2104-2181) defined by an invariant YD dipeptide flanked by an N-terminal hydrophobic residue and C-terminal [GD]xψ positions.","i":[[1630,1638,"FDYDSEGRL"],[1841,1849,"VDYDGQGRI"],[1881,1889,"FEYDMWDRL"],[2104,2112,"IQYDNMGRV"],[2130,2138,"YEYDVDGQL"],[2151,2159,"YNYDLNGNL"],[2173,2181,"LRYDLRDRI"],[2273,2281,"LYYDLQGHL"]]},{"c":"[DTN][GNQ]x[LI]YφxDx[NTG]","u":10,"sp":"dispersed","x":"structured_like","cf":"high","why":"Six beta-propeller-like blade core motifs distributed across residues 1181-1523, anchored by invariant Y and D positions alongside conserved [LI]φ hydrophobic core residues and flanking polar/glycine positions.","i":[[1183,1192,"DGSLYVGDFN"],[1225,1234,"TGDLYVSDTN"],[1294,1303,"NGLIYFVDGT"],[1354,1363,"DNSIYVLDNN"],[1482,1491,"DGTLYIADLG"],[1518,1527,"DQELYIFDIN"]]}],"s":"MDVKERRPYCSLTKSRREKERRYTNSSADNEECRVPTQKSYSSSETLKAFDHDSSRLLYGNRVKDLVHREADEFTRQGQNFTLRQLGVCEPATRRGLAFCAEMGLPHRGYSISAGSDADTENEAVMSPEHAMRLWGRGVKSGRSSCLSSRSNSALTLTDTEHENKSDSENEQPASNQGQSTLQPLPPSHKQHSAQHHPSITSLNRNSLTNRRNQSPAPPAALPAELQTTPESVQLQDSWVLGSNVPLESRHFLFKTGTGTTPLFSTATPGYTMASGSVYSPPTRPLPRNTLSRSAFKFKKSSKYCSWKCTALCAVGVSVLLAILLSYFIAMHLFGLNWQLQQTENDTFENGKVNSDTMPTNTVSLPSGDNGKLGGFTQENNTIDSGELDIGRRAIQEIPPGIFWRSQLFIDQPQFLKFNISLQKDALIGVYGRKGLPPSHTQYDFVELLDGSRLIAREQRSLLETERAGRQARSVSLHEAGFIQYLDSGIWHLAFYNDGKNAEQVSFNTIVIESVVECPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPGCSNHGVCIHGECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGPACNQRACHPRCAEHGTCKDGKCECSQGWNGEHCTIEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQNQPYCRGLPDPQDIISQSLQSPSQQAAKSFYDRISFLIGSDSTHVIPGESPFNKSLASVIRGQVLTADGTPLIGVNVSFFHYPEYGYTITRQDGMFDLVANGGASLTLVFERSPFLTQYHTVWIPWNVFYVMDTLVMKKEENDIPSCDLSGFVRPNPIIVSSPLSTFFRSSPEDSPIIPETQVLHEETTIPGTDLKLSYLSSRAAGYKSVLKITMTQSIIPFNLMKVHLMVAVVGRLFQKWFPASPNLAYTFIWDKTDAYNQKVYGLSEAVVSVGYEYESCLDLTLWEKRTAILQGYELDASNMGGWTLDKHHVLDVQNGILYKGNGENQFISQQPPVVSSIMGNGRRRSISCPSCNGQADGNKLLAPVALACGIDGSLYVGDFNYVRRIFPSGNVTSVLELSSNPAHRYYLATDPVTGDLYVSDTNTRRIYRPKSLTGAKDLTKNAEVVAGTGEQCLPFDEARCGDGGKAVEATLMSPKGMAVDKNGLIYFVDGTMIRKVDQNGIISTLLGSNDLTSARPLTCDTSMHISQVRLEWPTDLAINPMDNSIYVLDNNVVLQITENRQVRIAAGRPMHCQVPGVEYPVGKHAVQTTLESATAIAVSYSGVLYITETDEKKINRIRQVTTDGEISLVAGIPSECDCKNDANCDCYQSGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKNKPLLNSMNFYEVASPTDQELYIFDINGTHQYTVSLVTGDYLYNFSYSNDNDITAVTDSNGNTLRIRRDPNRMPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLELVLFTYHGNSGLLATKSDETGWTTFFDYDSEGRLTNVTFPTGVVTNLHGDMDKAITVDIESSSREEDVSITSNLSSIDSFYTMVQDQLRNSYQIGYDGSLRIIYASGLDSHYQTEPHVLAGTANPTVAKRNMTLPGENGQNLVEWRFRKEQAQGKVNVFGRKLRVNGRNLLSVDFDRTTKTEKIYDDHRKFLLRIAYDTSGHPTLWLPSSKLMAVNVTYSSTGQIASIQRGTTSEKVDYDGQGRIVSRVFADGKTWSYTYLEKSMVLLLHSQRQYIFEYDMWDRLSAITMPSVARHTMQTIRSIGYYRNIYNPPESNASIITDYNEEGLLLQTAFLGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDETAGVLKTVNLQSDGFICTIRYRQIGPLIDRQIFRFSEDGMVNARFDYSYDNSFRVTSMQGVINETPLPIDLYQFDDISGKVEQFGKFGVIYYDINQIISTAVMTYTKHFDAHGRIKEIQYEIFRSLMYWITIQYDNMGRVTKREIKIGPFANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYDLNGNLHLLNPSNSARLTPLRYDLRDRITRLGDVQYRLDEDGFLRQRGTEIFEYSSKGLLTRVYSKGSGWTVIYRYDGLGRRVSSKTSLGQHLQFFYADLTYPTRITHVYNHSSSEITSLYYDLQGHLFAMEISSGDEFYIASDNTGTPLAVFSSNGLMLKQIQYTAYGEIYFDSNIDFQLVIGFHGGLYDPLTKLIHFGERDYDILAGRWTTPDIEIWKRIGKDPAPFNLYMFRNNNPASKIHDVKDYITDVNSWLVTFGFHLHNAIPGFPVPKFDLTEPSYELVKSQQWDDIPPIFGVQQQVARQAKAFLSLGKMAEVQVSRRRAGGAQSWLWFATVKSLIGKGVMLAVSQGRVQTNVLNIANEDCIKVAAVLNNAFYLENLHFTIEGKDTHYFIKTTTPESDLGTLRLTSGRKALENGINVTVSQSTTVVNGRTRRFADVEMQFGALALHVRYGMTLDEEKARILEQARQRALARAWAREQQRVRDGEEGARLWTEGEKRQLLSAGKVQGYDGYYVLSVEQYPELADSANNIQFLRQSEIGRR"},{"id":"SEQ_07993","a":"Q9UN72","g":"PCDHA7","d":"Protocadherin alpha-7","L":937,"m":[{"c":"(x){4,12}[YLR]xψ(x){15,18}Dx[DG]xxxxxxψxxx[LF](x){23,28}ψDx[ET](x){16,19}P(x){5,7}[VL]x[VI]x[VL]x-(x){3,4}[AP]Pxφ","u":"105-113","sp":"tandem","x":"structured_like","cf":"high","why":"Six head-to-tail tandem ~105-113 aa structured repeats spanning residues 29-678, anchored by internal Dx[DG]xxxxxxψxxx[LF] and ψDx[ET] motifs, a conserved P-turn, and an alternating aliphatic [VL]x[VI]x[VL]x strand followed by a C-terminal DxNDN[AP]Px[FL] motif in copies 1-5 (diverging to ESGQAPKA in the terminal 6th copy).","i":[[29,133,"GQLHYSVPEEAKHGNFVGRIAQDLGLELAELVPRLFRAVCKFRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVERPLQVFHVDVEVKDINDNPPVF"],[134,242,"PATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVF"],[243,350,"DRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQL"],[351,455,"TLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAF"],[456,565,"AQPEYTVFVKENNPPGCHIFTVSAGDADAQKNALVSYSLVELRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL"],[566,678,"LAPRVGGTGGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPVAAGASIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPSLTATATVLVSLVESGQAPKA"]]}],"s":"MVCPNGYDPGGRHLLLFIIILAAWEAGRGQLHYSVPEEAKHGNFVGRIAQDLGLELAELVPRLFRAVCKFRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVERPLQVFHVDVEVKDINDNPPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNALVSYSLVELRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPVAAGASIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPSLTATATVLVSLVESGQAPKASSRASLGIAGPETELVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAPSSEGACSLVKPTLVCSSAVGSWSFSQQRRQRVCSGEGPPKTDLMAFSPSLPQGPSSTDNPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ"},{"id":"SEQ_08009","a":"Q2PPJ7","g":"RALGAPA2","d":"Ral GTPase-activating protein subunit alpha-2","L":1873,"m":[{"c":"xφxxφ[LI]xxxxxxPN[ETK][YI]xxxx[LA]xxxxxxxxxxxxx","u":34,"sp":"dispersed","x":"structured_like","cf":"medium","why":"Four 34-aa alpha-solenoid (HEAT-like) helix-turn-helix repeats in the central structured region (one upstream copy at 996-1029 and three regularly spaced ~42-aa repeats spanning 1103-1220), anchored by a conserved hydrophobic N-terminal helix core (φxxφ[LI]), an invariant inter-helix PN[ETK][YI] turn kink, and a conserved hydrophobic C-terminal helix core (including strong pairwise conservation between EAVTVLGSLVCFPNT and EAINVIGVTLKFPNK).","i":[[993,1026,"MFASWLFKAATLPNEYKEGKLQAYRLICAMMTRR"],[1100,1133,"EAVTVLGSLVCFPNTYQEIPLLQSVPEVNEAITG"],[1141,1174,"LINILLKNATEEPNEYARCIAVCSLGVWICEELA"],[1184,1217,"EAINVIGVTLKFPNKIVAQVACDVLQLLVSYWEK"]]}],"s":"MFSRRSHGDVKKSTQKVLDPKKDVLTRLKHLRALLDNVDANDLKQFFETNYSQIYFIFYENFIALENSLKLKGNNKSQREELDSILFLFEKILQFLPERIFFRWHYQSIGSTLKKLLHTGNSIKIRCEGIRLFLLWLQALQTNCAEEQVLIFACLVPGFPAVMSSRGPCTLETLINPSPSVADVKIYPEEITPLLPAISGEKIAEDQTCFFLQILLKYMVIQAASLEWKNKENQDTGFKFLFTLFRKYYLPHLFPSFTKLTNIYKPVLDIPHLRPKPVYITTTRDNENIYSTKIPYMAARVVFIKWIVTFFLEKKYLTATQNTKNGVDVLPKIIQTVGGGAVQERAPELDGGGPTEQDKSHSNSSTLSDRRLSNSSLCSIEEEHRMVYEMVQRILLSTRGYVNFVNEVFHQAFLLPSCEIAVTRKVVQVYRKWILQDKPVFMEEPDRKDVAQEDAEKLGFSETDSKEASSESSGHKRSSSWGRTYSFTSAMSRGCVTEEENTNVKAGVQALLQVFLTNSANIFLLEPCAEVPVLLKEQVDACKAVLIIFRRMIMELTMNKKTWEQMLQILLRITEAVMQKPKDKQIKDLFAQSLAGLLFRTLMVAWIRANLCVYISRELWDDFLGVLSSLTEWEELINEWANIMDSLTAVLARTVYGVEMTNLPLDKLSEQKEKKQRGKGCVLDPQKGTTVGRSFSLSWRSHPDVTEPMRFRSATTSGAPGVEKARNIVRQKATEVEECQQSENAPAAGSGHLTVGQQQQVLRSSSTSDIPEPLCSDSSQGQKAENTQNSSSSEPQPIQENKGHVKREHEGITILVRRSSSPAELDLKDDLQQTQGKCRERQKSESTNSDTTLGCTNEAELSMGPWQTCEEDPELNTPTDVVADADARHWLQLSPTDASNLTDSSECLTDDCSIIAGGSLTGWHPDSAAVLWRRVLGILGDVNNIQSPKIHARVFCYLYELWYKLAKIRDNLAISLDNQSSPSPPVLIPPLRMFASWLFKAATLPNEYKEGKLQAYRLICAMMTRRQDVLPNSDFLVHFYLVMHLGLTSEDQDILNTIIRHCPPRFFSLGFPGFSMLVGDFITAAARVLSTDILTAPRSEAVTVLGSLVCFPNTYQEIPLLQSVPEVNEAITGTEDVKHYLINILLKNATEEPNEYARCIAVCSLGVWICEELAQCTSHPQVKEAINVIGVTLKFPNKIVAQVACDVLQLLVSYWEKLQMFETSLPRKMAEILVATVAFLLPSAEYSSVETDKKFIVSLLLCLLDWCMALPVSVLLHPVSTAVLEEQHSARAPLLDYIYRVLHCCVCGSSTYTQQSHYILTLADLSSTDYDPFLPLANVKSSEPVQYHSSAELGNLLTVEEEKKRRSLELIPLTARMVMAHLVNHLGHYPLSGGPAILHSLVSENHDNAHVEGSELSFEVFRSPNLQLFVFNDSTLISYLQTPTEGPVGGSPVGSLSDVRVIVRDISGKYSWDGKVLYGPLEGCLAPNGRNPSFLISSWHRDTFGPQKDSSQVEEGDDVLDKLLENIGHTSPECLLPSQLNLNEPSLTPCGMNYDQEKEIIEVILRQNAQEDEYIQSHNFDSAMKVTSQGQPSPVEPRGPFYFCRLLLDDLGMNSWDRRKNFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAGLGWEVDLSTHCGFMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPSDSDDSLTKKLRHLGNDEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFIAITKKPEVPFFGPLFDGAIVSGKLLPSLVCATCINASRAVKCLIPLYQSFYEERALYLEAIIQNHREVMTFEDFAAQVFSPSPSYSLSGTD"},{"id":"SEQ_08012","a":"P25440","g":"BRD2","d":"Bromodomain-containing protein 2","L":801,"m":[{"c":"KxG+ψ[ST]xQLxxxxxψψxxφLxK(x){2,4}ΩAWPFxxPVDAxxLGLxDYHxIIKxPMDψ[GS]TψKR+ψENxxYxxAoExφxDφxxMF[ST]NCYxYNxPxxDψVφMAxxLxxψFxx+φAxMPxE","u":"113-115","sp":"dispersed","x":"structured_like","cf":"high","why":"Two highly conserved ~113-115 aa structured domain copies separated by a ~158 aa proline/polar-rich linker, sharing extensive fixed anchors (including AWPF, PVDA, LGL, DYH, IIKxPMD, MF[ST]NCYxY, and MPxE) and hydrophobic core positions across the entire fold with a minor 2-residue loop length difference.","i":[[71,183,"KPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQE"],[342,456,"KKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDE"]]}],"s":"MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG"},{"id":"SEQ_08024","a":"Q5VY43","g":"PEAR1","d":"Platelet endothelial aggregation receptor 1","L":1037,"m":[{"c":"CxCxxGΩxGxxC(x){3,4}CPxGxΩGxxC(x){2,3}CxC(x){4,6}CxxxxGx","u":"42-46","sp":"tandem","x":"structured_like","cf":"high","why":"Fourteen head-to-tail tandem 42-46 aa cysteine-rich repeats anchored by an invariant eight-cysteine register (CxC...C...C...C...CxC...C), conserved GΩxG dyads in the first two subdomains, and an invariant penultimate glycine.","i":[[120,162,"CQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKSGV"],[163,204,"CSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGA"],[205,247,"CFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGS"],[248,290,"CSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQ"],[291,333,"CRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFPANGA"],[334,379,"CLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGE"],[380,422,"CSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGL"],[423,465,"CQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGE"],[466,508,"CVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGA"],[509,551,"CTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGR"],[552,594,"CQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGN"],[595,636,"CVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGT"],[637,679,"CYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGS"],[680,722,"CICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPETGA"]]}],"s":"MSPPLCPLLLLAVGLRLAGTLNPSDPNTCSFWESFTTTTKESHSRPFSLLPSEPCERPWEGPHTCPQPTVVYRTVYRQVVKTDHRQRLQCCHGFYESRGFCVPLCAQECVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPETGACVCPPGHSGAPCRIGIQEPFTVMPTTPVAYNSLGAVIGIAVLGSLVVALVALFIGYRHWQKGKEHHHLAVAYSSGRLDGSEYVMPDVPPSYSHYYSNPSYHTLSQCSPNPPPPNKVPGPLFASLQNPERPGGAQGHDNHTTLPADWKHRREPPPGPLDRGSSRLDRSYSYSYSNGPGPFYNKGLISEEELGASVASLSSENPYATIRDLPSLPGGPRESSYMEMKGPPSGSPPRQPPQFWDSQRRRQPQPQRDSGTYEQPSPLIHDRDSVGSQPPLPPGLPPGHYDSPKNSHIPGHYDLPPVRHPPSPPLRRQDR"},{"id":"SEQ_08027","a":"Q7Z5Q1","g":"CPEB2","d":"Cytoplasmic polyadenylation element-binding protein 2","L":589,"m":[{"c":"RK(x){0,1}ψFVGGψPxxψxxxEψxφxφxRφx(x){16,17}PKGφ[AG]xψφFoxxoSφxAφIAxφ","u":65,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two 65 aa structured domain repeats separated by a 42 aa linker, strongly conserved across both core submotifs (N-terminal RK-ψFVGGψP-helix and C-terminal PKGφ[AG]xψφF-SφxAφIAxφ motif).","i":[[332,396,"RKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACI"],[439,503,"RKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARF"]]}],"s":"MPPPSPDSENGFYPGLPSSMNPAFFPSFSPVSPHGCTGLSVPTSGGGGGGFGGPFSATAVPPPPPPAMNIPQQQPPPPAAPQQPQSRRSPVSPQLQQQHQAAAAAFLQQRNSYNHHQPLLKQSPWSNHQSSGWGTGSMSWGAMHGRDHRRTGNMGIPGTMNQISPLKKPFSGNVIAPPKFTRSTPSLTPKSWIEDNVFRTDNNSNTLLPLQVRSSLQLPAWGSDSLQDSWCTAAGTSRIDQDRSRMYDSLNMHSLENSLIDIMRAEHDPLKGRLSYPHPGTDNLLMLNGRSSLFPIDDGLLDDGHSDQVGVLNSPTCYSAHQNGERIERFSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGDIDKRVEVKPYVLDDQMCDECQGARCGGKFAPFFCANVTCLQYYCEFCWANIHSRAGREFHKPLVKEGADRPRQIHFRWN"},{"id":"SEQ_08063","a":"P0C879","g":"YJ018_HUMAN","d":"Putative uncharacterized protein FLJ43185","L":139,"m":[{"c":"[GR]PR[PV][FV]","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed copies in a proline/arginine/serine-rich disordered sequence share a fixed PR anchor flanked by [GR] at position 1, [PV] at position 4, and [FV] at position 5, arranged as two N-terminal [GR]PRPF copies (followed by PTPR/SSSPR) and two C-terminal [GR]PR[PV]V copies (extended by ARG).","i":[[17,21,"GPRPF"],[50,54,"RPRPF"],[67,71,"GPRPV"],[108,112,"RPRVV"]]}],"s":"MYNPWQVGASLAPARAGPRPFPTPRARPPDCSGGHAPSGFPALGLRTAQRPRPFSSSPRSASGRLRGPRPVARGPAHSSSPTGLPAYLPPAAALDSQTSAPTVSPVTRPRVVARGKTPRVSLAGLETLSSLLHQQQLFD"},{"id":"SEQ_08082","a":"O95428","g":"PAPLN","d":"Papilin","L":1278,"m":[{"c":"W(x){4,5}W[SAG]xCSx[STE]C[GS][GSV]GxxxRx[VR]xC(x){7,16}C(x){9,13}CxxxxC","u":"51-59","sp":"dispersed","x":"structured_like","cf":"high","why":"Five 51-59 aa cysteine-rich repeats anchored by an N-terminal W(x){4,5}WxxCSxxCGGGxxxRxxxC motif and a C-terminal C(x){9,13}CxxxxC disulfide-like signature, with one N-terminal copy and four clustered central copies.","i":[[29,79,"WGPWSQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPARSHRSCRTESC"],[308,360,"WSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPC"],[366,424,"WKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC"],[427,480,"WSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDC"],[488,538,"WHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQPC"]]},{"c":"P[SRT]ψ[VT](x){3,4}G[QD]xxRψxC(x){10,11}W[QS]+[DN]G[QL]Pψ[SQ][SA][DP][RG]H[RQ]ψ[QH](x){1,3}DG[ST]LψIxxψxxxDxGxY[ST]C(x){12,13}[QE]ψ+ψψ","u":"80-81","sp":"dispersed","x":"structured_like","cf":"high","why":"Three 80-81 aa structured repeats in the C-terminal region sharing invariant C, W, G, P, H, DGT/SL, and DxGxY[ST]C anchors plus a C-terminal [QE]ψ+ψψ hydrophobic-basic motif separated by 54 aa and 9 aa linkers.","i":[[916,995,"PSLVQAALGQLVRLSCSDDTAPESQAAWQKDGQPISSDRHRLQFDGSLIIHPLQAEDAGTYSCGSTRPGRDSQKIQLRII"],[1050,1130,"PRVVDASPGQRIRMTCRAEGFPPPAIEWQRDGQPVSSPRHQLQPDGSLVISRVAVEDGGFYTCVAFNGQDRDQRWVQLRVL"],[1140,1220,"PTVTVPEGDTARLLCVVAGESVNIRWSRNGLPVQADGHRVHQSPDGTLLIYNLRARDEGSYTCSAYQGSQAVSRSTEVKVV"]]},{"c":"C[RQ]xSx[HYF]GCC[PY]Dx[VH][TSA][AVT][AS]xGPxxxGC","u":24,"sp":"dispersed","x":"structured_like","cf":"high","why":"Three ungapped 24 aa repeats defined by four invariant cysteines including a central GCC[PY]D motif, a conserved Sx[HYF] N-terminal core, and a C-terminal GPxxxGC segment separated by 4 aa and 37 aa linkers.","i":[[630,653,"CRHSPHGCCPDGHTASLGPQWQGC"],[658,681,"CQQSRYGCCPDRVSVAEGPHHAGC"],[719,742,"CRGSQFGCCYDNVATAAGPLGEGC"]]}],"s":"MRLLLLVPLLLAPAPGSSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPARSHRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENFYYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDANDLSRGYNQILIVPMGATSILIDEAAASRNFLAVKNVRGEYYLNGHWTIEAARALPAASTILHYERGAEGDLAPERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPCPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQPCHLPQEVPSMQDVHTPASNPWMPLGPQESPASDSRGQWWAAQEHPSARGDHRGERGDPRGDQGTHLSALGPAPSLQQPPYQQPLRSGSGPHDCRHSPHGCCPDGHTASLGPQWQGCPGAPCQQSRYGCCPDRVSVAEGPHHAGCTKSYGGDSTGGMPRSRAVASTVHNTHQPQAQQNEPSECRGSQFGCCYDNVATAAGPLGEGCVGQPSHAYPVRCLLPSAHGSCADWAARWYFVASVGQCNRFWYGGCHGNANNFASEQECMSSCQGSLHGPRRPQPGASGRSTHTDGGGSSPAGEQEPSQHRTGAAVQRKPWPSGGLWRQDQQPGPGEAPHTQAFGEWPWGQELGSRAPGLGGDAGSPAPPFHSSSYRISLAGVEPSLVQAALGQLVRLSCSDDTAPESQAAWQKDGQPISSDRHRLQFDGSLIIHPLQAEDAGTYSCGSTRPGRDSQKIQLRIIGGDMAVLSEAELSRFPQPRDPAQDFGQAGAAGPLGAIPSSHPQPANRLRLDQNQPRVVDASPGQRIRMTCRAEGFPPPAIEWQRDGQPVSSPRHQLQPDGSLVISRVAVEDGGFYTCVAFNGQDRDQRWVQLRVLGELTISGLPPTVTVPEGDTARLLCVVAGESVNIRWSRNGLPVQADGHRVHQSPDGTLLIYNLRARDEGSYTCSAYQGSQAVSRSTEVKVVSPAPTAQPRDPGRDCVDQPELANCDLILQAQLCGNEYYSSFCCASCSRFQPHAQPIWQ"},{"id":"SEQ_08084","a":"Q5T3I0","g":"GPATCH4","d":"G patch domain-containing protein 4","L":446,"m":[{"c":"[TA][ER]E[AV]ESRAx[AST][DG]xxSRx(x){0,2}+KRQQ[QH](x){0,1}[EK][EK]E[DR]","u":"26-29","sp":"periodic","x":"disordered_like","cf":"high","why":"Three periodic 26-29 aa repeats in the C-terminal disordered region separated by regular 12-15 aa linkers (~40-41 aa start-to-start period), anchored by an invariant E[AV]ESRA core and downstream +KRQQ[QH]..E[DR] module (which also has diverged N-terminal echoes around positions 205-302).","i":[[321,346,"TEEVESRAYADPCSRRKKRQQQEEED"],[362,390,"TREAESRACSDGRSRKSKKKRQQHQEEED"],[402,429,"AREAESRAHTGSSSRGKRKRQQHPKKER"]]}],"s":"MNVTPEVKSRGMKFAEEQLLKHGWTQGKGLGRKENGITQALRVTLKQDTHGVGHDPAKEFTNHWWNELFNKTAANLVVETGQDGVQIRSLSKETTRYNHPKPNLLYQKFVKMATLTSGGEKPNKDLESCSDDDNQGSKSPKILTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETVLGGGTREAESRACSDGRSRKSKKKRQQHQEEEDILDVRDEKDGGAREAESRAHTGSSSRGKRKRQQHPKKERAGVSTVQKAKKKQKKRD"},{"id":"SEQ_08098","a":"H0YM25","g":"GOLGA6L22","d":"Golgin subfamily A member 6-like protein 22","L":854,"m":[{"c":"[ER]QEE[KM]ψx","u":7,"sp":"tandem","x":"structured_like","cf":"high","why":"Extensive C-terminal tandem array (positions 291-852) of 68 sequence-specific 7-aa units (with occasional 6-aa shortened variants and higher-order ~49-70 aa duplications) anchored by conserved Q2, E3-E4, [KM]5, and strictly conserved large aliphatic ψ6 (I/M/V), distinct from generic unanchored E/K/R rods.","i":[[291,297,"QQEEKMW"],[298,304,"RQEEKIQ"],[305,311,"EWEEKIQ"],[312,318,"EQEEKIR"],[319,325,"EQEEKIR"],[326,332,"EQEEKMR"],[333,339,"RQEEMMW"],[340,346,"EKEEKMR"],[347,353,"RQEEMMW"],[354,360,"EKEEKIR"],[361,367,"ELEEKMH"],[380,386,"QEEEKIR"],[393,399,"EQEAKMW"],[400,406,"RQEEKIR"],[407,413,"EQEEKIR"],[414,420,"EQEKKMW"],[421,427,"RQEEKIH"],[446,452,"RQEEKIR"],[459,465,"RQKEKMH"],[466,472,"EQEEKIR"],[473,479,"KQEEKVW"],[480,486,"RQEEKMH"],[487,493,"DQEEKIR"],[494,500,"EQEEKVW"],[501,507,"RQEEKIR"],[514,520,"EQEEKMW"],[521,527,"RQEEKIR"],[528,534,"EQEEKIR"],[541,547,"REEEKMH"],[560,566,"EQEDKMW"],[567,573,"RQEEKIR"],[574,580,"EQEEKVW"],[581,587,"RQEEKIR"],[595,601,"EQEEKMW"],[602,608,"KQEEKIR"],[609,615,"EQEEKIR"],[616,622,"EQEEKIR"],[623,629,"EQEEKIR"],[630,636,"EQEEMMQ"],[637,643,"EQEEKMG"],[644,650,"EQEEKMQ"],[657,663,"RQEEKIR"],[664,670,"EQEEKIR"],[671,677,"EQKEKIR"],[678,684,"EQEEKIW"],[685,691,"EQEEKIR"],[692,698,"EQEEMMQ"],[699,705,"EQEEKMG"],[706,712,"EQEEKIW"],[713,719,"EQEEKMQ"],[720,726,"EQEEKMR"],[727,733,"RQEEKIR"],[734,740,"EQEKKIR"],[741,747,"EQEEKIR"],[748,754,"EQEEMMQ"],[755,761,"EQEEKMG"],[762,768,"EQEEKMQ"],[769,775,"EQEEKMR"],[776,782,"RQEEKIR"],[783,789,"EQEKKIR"],[790,796,"EQEEKIR"],[797,803,"EQEEMMQ"],[804,810,"EQEEKMW"],[811,817,"EQEEKMC"],[818,824,"EQEEKMQ"],[825,831,"EQEEKMR"],[832,838,"RQEEKMW"],[846,852,"QQEEKMQ"]]},{"c":"PHLPTH","u":6,"sp":"tandem","x":"disordered_like","cf":"high","why":"Six exact head-to-tail tandem copies of the 6-aa motif PHLPTH in the N-terminal tail (positions 7-42), anchored by invariant P, H, L, and T positions.","i":[[7,12,"PHLPTH"],[13,18,"PHLPTH"],[19,24,"PHLPTH"],[25,30,"PHLPTH"],[31,36,"PHLPTH"],[37,42,"PHLPTH"]]}],"s":"MLMWPQPHLPTHPHLPTHPHLPTHPHLPTHPHLPTHPHLPTHPMMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTSPETTTSGGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVTTQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEKKREQEEKMWRQEEKIREQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMGEQEEKIWEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEH"},{"id":"SEQ_08129","a":"P54198","g":"HIRA","d":"Protein HIRA","L":1017,"m":[{"c":"xxxx[HD](x){7,9}[WI]xxx[GD]xxφ[AL][STV][GCQ][GSA](x){1,3}D(x){2,3}ψxφ[WL]x","u":"33-38","sp":"dispersed","x":"structured_like","cf":"high","why":"Five beta-propeller-like structural repeats in the N-terminal domain anchored by N-terminal H/D, central [WI]xxx[GD]xxφ[AL][STV], invariant D, and C-terminal ψxφ[WL]x hydrophobic-aromatic core, separated by variable linkers including a divergent loop-inserted region before the fifth copy.","i":[[7,44,"TWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWN"],[65,98,"QMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWK"],[126,159,"ILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWN"],[169,202,"TLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWR"],[324,356,"HELFDKSIMDISWTLNGLGILVCSMDGSVAFLD"]]}],"s":"MKLLKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQDELGDPLSEEEKSRIHQSTYGKSLAIMTEAQLSTAVIENPEMLKYQRRQQQQQLDQKSAATREMGSATSVAGVVNGESLEDIRKNLLKKQVETRTADGRRRITPLCIAQLDTGDFSTAFFNSIPLSGSLAGTMLSSHSSPQLLPLDSSTPNSFGASKPCTEPVVAASARPAGDSVNKDSMNATSTPAALSPSVLTTPSKIEPMKAFDSRFTERSKATPGAPALTSMTPTAVERLKEQNLVKELRPRDLLESSSDSDEKVPLAKASSLSKRKLELEVETVEKKKKGRPRKDSRLMPVSLSVQSPAALTAEKEAMCLSAPALALKLPIPSPQRAFTLQVSSDPSMYIEVENEVTVVGGVKLSRLKCNREGKEWETVLTSRILTAAGSCDVVCVACEKRMLSVFSTCGRRLLSPILLPSPISTLHCTGSYVMALTAAATLSVWDVHRQVVVVKEESLHSILAGSDMTVSQILLTQHGIPVMNLSDGKAYCFNPSLSTWNLVSDKQDSLAQCADFRSSLPSQDAMLCSGPLAIIQGRTSNSGRQAARLFSVPHVVQQETTLAYLENQVAAALTLQSSHEYRHWLLVYARYLVNEGFEYRLREICKDLLGPVHYSTGSQWESTVVGLRKRELLKELLPVIGQNLRFQRLFTECQEQLDILRDK"},{"id":"SEQ_08135","a":"O94856","g":"NFASC","d":"Neurofascin","L":1347,"m":[{"c":"xx[LI]xC(x){11,13}W(x){32,40}YxCx[AT](x){12,15}ψxV","u":"70-78","sp":"periodic","x":"structured_like","cf":"high","why":"Six regularly spaced ~70-78 aa structured repeats in the N-terminal half defined by invariant disulfide-like cysteines, a conserved core tryptophan, a YxCx[AT] signature, and C-terminal ψxV.","i":[[59,136,"ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQV"],[158,233,"LTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKV"],[264,333,"LLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRV"],[354,425,"GRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSV"],[448,518,"TRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEV"],[539,609,"VQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV"]]},{"c":"P(x){12,16}φx[LI]xW(x){12,14}Y(x){25,38}P(x){3,4}Yx[FIL]xψx[AVS](x){4}G","u":"77-87","sp":"dispersed","x":"structured_like","cf":"high","why":"Five ~77-87 aa beta-sandwich-like repeats (four closely spaced plus a fifth separated by a Pro/Thr/Ala-rich low-complexity linker) anchored by conserved N-terminal P, φx[LI]xW, central Y, and C-terminal P(x){3,4}Yx[FIL]xψx[AVS](x){4}G.","i":[[631,709,"PRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVG"],[731,808,"PGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYVVGQTPVYVPYEIRVQAENDFG"],[829,915,"PTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRG"],[935,1014,"PRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVG"],[1115,1191,"PDEQSIWNVTVLPNSKWANITWKHNFGPGTDFVVEYIDSNHTKKTVPVKAQAQPIQLTDLYPGMTYTLRVYSRDNEG"]]},{"c":"[EN][ES]D[GD]S[FL]","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 6-aa acidic-polar-hydrophobic motifs in the C-terminal disordered tail anchored by invariant D and S and conserved C-terminal [FL] (each immediately followed within 1-3 residues by a tyrosine: EEDGSFDY, ESDDSLVDY, NEDGSFIGQY).","i":[[1263,1268,"EEDGSF"],[1293,1298,"ESDDSL"],[1310,1315,"NEDGSF"]]}],"s":"MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAPPTLPPTTVGATGAVSSTDATAIAATTEATTVPIIPTVAPTTIATTTTVATTTTTTAAATTTTESPPTTTSGTKIHESAPDEQSIWNVTVLPNSKWANITWKHNFGPGTDFVVEYIDSNHTKKTVPVKAQAQPIQLTDLYPGMTYTLRVYSRDNEGISSTVITFMTSTAYTNNQADIATQGWFIGLMCAIALLVLILLIVCFIKRSRGGKYPVREKKDVPLGPEDPKEEDGSFDYSDEDNKPLQGSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDGSFIGQYTVKKDKEETEGNESSEATSPVNAIYSLA"},{"id":"SEQ_08150","a":"Q66K41","g":"ZNF385C","d":"Zinc finger protein 385C","L":422,"m":[{"c":"φxCxxCxψx[FV]NS[AE]oQ[AL]x[AQ]Hxx[GS]x+H","u":25,"sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed, gapless 25-aa C2H2-type repeats anchored by invariant CxxC and Hxxxx+H coordination motifs plus a strongly conserved internal NS[AE]oQ[AL]x[AQ]H recognition segment.","i":[[77,101,"ISCNICHLRFNSANQAEAHYKGHKH"],[221,245,"LYCPTCKVTVNSASQLQAHNTGAKH"],[290,314,"FHCALCQLQVNSETQLKQHMSSRRH"]]}],"s":"MLLGPASGAPSPLLASLPLPTRPLQPPLDFKHLLAFHFNGAAPLSLFPNFSTMDPVQKAVISHTFGVPSPLKKKLFISCNICHLRFNSANQAEAHYKGHKHARKLKAVEAAKSKQRPHTQAQDGAVVSPIPTLASGAPGEPQSKVPAAPPLGPPLQPPPTPDPTCREPAHSELLDAASSSSSSSCPPCSPEPGREAPGPEPAAAAVGSSMSGEGRSEKGHLYCPTCKVTVNSASQLQAHNTGAKHRWMMEGQRGAPRRSRGRPVSRGGAGHKAKRVTGGRGGRQGPSPAFHCALCQLQVNSETQLKQHMSSRRHKDRLAGKTPKPSSQHSKLQKHAALAVSILKSKLALQKQLTKTLAARFLPSPLPTAATAICALPGPLALRPAPTAATTLFPAPILGPALFRTPAGAVRPATGPIVLAPY"},{"id":"SEQ_08154","a":"Q15751","g":"HERC1","d":"Probable E3 ubiquitin-protein ligase HERC1","L":4861,"m":[{"c":"xxxx(x){0,1}[WFC]G(x){4,6}[LC]xx[GA](x){21,26}Gxx(x){0,1}[STC]φ[AV]φxxx[GNP]","u":"49-55","sp":"tandem","x":"structured_like","cf":"high","why":"Fourteen 49-55 aa structured beta-propeller-like repeats organized into two head-to-tail 7-copy tandem arrays (N-terminal and C-terminal), anchored by a conserved [WFC]G...LxxG glycine-rich motif, an invariant internal G, and a C-terminal [STC]φ[AV]φxxx[GNP] beta-strand signature.","i":[[373,422,"EVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDG"],[423,477,"SVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEG"],[478,530,"EVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDG"],[531,580,"ELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDG"],[581,633,"RTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTG"],[634,684,"QVYAWGCGACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDN"],[685,737,"EVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWTALP"],[3998,4046,"DVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANG"],[4047,4101,"TVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESG"],[4102,4153,"EVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDG"],[4154,4205,"KLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADG"],[4206,4258,"SMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDG"],[4259,4310,"HVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNG"],[4311,4362,"DVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAPP"]]},{"c":"[LIS]xxH(x){1,3}ψxxxx[WF](x){4,15}[LI][LA]φ[TVA](x){6,9}ψxψ[WV]","u":"32-43","sp":"dispersed","x":"structured_like","cf":"high","why":"Five non-overlapping 32-43 aa structured repeats in the C-terminal half separated by variable linkers, defined by an N-terminal H(x){1,3}ψxxxx[WF] motif, a hydrophobic [LI][LA]φ[TVA] core strand, and a C-terminal ψxψ[WV] anchor.","i":[[3424,3455,"LEAHQNRVMTCVWCNKKGLLATSGNDGTIRVW"],[3523,3565,"IQPHWVSALAWPEEGPATAWSGESPELLLVGRMDGSLGLIEVV"],[3622,3653,"IDAHKDTLISMKWDPTGHILMTCAKEDSVKLW"],[3665,3703,"SLCHPSIVNGIAWCRLPGKGSKLQLLMATGCQSGLVCVW"],[3743,3774,"LRGHITPVRTVAFSSDGLALVSGGLGGLMNIW"]]}],"s":"MATMIPPVKLKWLEHLNSSWITEDSESIATREGVAVLYSKLVSNKEVVPLPQQVLCLKGPQLPDFERESLSSDEQDHYLDALLSSQLALAKMVCSDSPFAGALRKRLLVLQRVFYALSNKYHDKGKVKQQQHSPESSSGSADVHSVSERPRSSTDALIEMGVRTGLSLLFALLRQSWMMPVSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKIPPMGLDCLSQVTTFLKGVTIPNSGADTLGRRLASELLLGLAAQRGSLRYLLEWIEMALGASAVVHTMEKGKLLSSQEGMISFDCFMTILMQMRRSLGSSADRSQWREPTRTSDGLCSLYEAALCLFEEVCRMASDYSRTCASPDSIQTGDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWTALPRDRQVVAWHRPYCVDLEESTFSHLRSFLERYCDKINSEIPPLPFPSSREHHSFLKLCLKLLSNHLALALAGGVATSILGRQAGPLRNLLFRLMDSTVPDEIQEVVIETLSVGATMLLPPLRERMELLHSLLPQGPDRWESLSKGQRMQLDIILTSLQDHTHVASLLGYSSPSDAADLSSVCTGYGNLSDQPYGTQSCHPDTHLAEILMKTLLRNLGFYTDQAFGELEKNSDKFLLGTSSSENSQPAHLHELLCSLQKQLLAFCHINNISENSSSVALLHKHLQLLLPHATDIYSRSANLLKESPWNGSVGEKLRDVIYVSAAGSMLCQIVNSLLLLPVSVARPLLSYLLDLLPPLDCLNRLLPAADLLEDQELQWPLHGGPELIDPAGLPLPQPAQSWVWLVDLERTIALLIGRCLGGMLQGSPVSPEEQDTAYWMKTPLFSDGVEMDTPQLDKCMSCLLEVALSGNEEQKPFDYKLRPEIAVYVDLALGCSKEPARSLWISMQDYAVSKDWDSATLSNESLLDTVSRFVLAALLKHTNLLSQACGESRYQPGKHLSEVYRCVYKVRSRLLACKNLELIQTRSSSRDRWISENQDSADVDPQEHSFTRTIDEEAEMEEQAERDREEGHPEPEDEEEEREHEVMTAGKIFQCFLSAREVARSRDRDRMNSGAGSGARADDPPPQSQQERRVSTDLPEGQDVYTAACNSVIHRCALLILGVSPVIDELQKRREEGQLQQPSTSASEGGGLMTRSESLTAESRLVHTSPNYRLIKSRSESDLSQPESDEEGYALSGRRNVDLDLAASHRKRGPMHSQLESLSDSWARLKHSRDWLCNSSYSFESDFDLTKSLGVHTLIENVVSFVSGDVGNAPGFKEPEESMSTSPQASIIAMEQQQLRAELRLEALHQILVLLSGMEEKGSISLAGSRLSSGFQSSTLLTSVRLQFLAGCFGLGTVGHTGGKGESGRLHHYQDGIRAAKRNIQIEIQVAVHKIYQQLSATLERALQANKHHIEAQQRLLLVTVFALSVHYQPVDVSLAISTGLLNVLSQLCGTDTMLGQPLQLLPKTGVSQLSTALKVASTRLLQILAITTGTYADKLSPKVVQSLLDLLCSQLKNLLSQTGVLHMASFGEGEQEDGEEEEKKVDSSGETEKKDFRAALRKQHAAELHLGDFLVFLRRVVSSKAIQSKMASPKWTEVLLNIASQKCSSGIPLVGNLRTRLLALHVLEAVLPACESGVEDDQMAQIVERLFSLLSDCMWETPIAQAKHAIQIKEKEQEIKLQKQGELEEEDENLPIQEVSFDPEKAQCCLVENGQILTHGSGGKGYGLASTGVTSGCYQWKFYIVKENRGNEGTCVGVSRWPVHDFNHRTTSDMWLYRAYSGNLYHNGEQTLTLSSFTQGDFITCVLDMEARTISFGKNGEEPKLAFEDVDAAELYPCVMFYSSNPGEKVKICDMQMRGTPRDLLPGDPICSPVAAVLAEATIQLIRILHRTDRWTYCINKKMMERLHKIKICIKESGQKLKKSRSVQSREENEMREEKESKEEEKGKHTRHGLADLSELQLRTLCIEVWPVLAVIGGVDAGLRVGGRCVHKQTGRHATLLGVVKEGSTSAKVQWDEAEITISFPTFWSPSDTPLYNLEPCEPLPFDVARFRGLTASVLLDLTYLTGVHEDMGKQSTKRHEKKHRHESEEKGDVEQKPESESALDMRTGLTSDDVKSQSTTSSKSENEIASFSLDPTLPSVESQHQITEGKRKNHEHMSKNHDVAQSEIRAVQLSYLYLGAMKSLSALLGCSKYAELLLIPKVLAENGHNSDCASSPVVHEDVEMRAALQFLMRHMVKRAVMRSPIKRALGLADLERAQAMIYKLVVHGLLEDQFGGKIKQEIDQQAEESDPAQQAQTPVTTSPSASSTTSFMSSSLEDTTTATTPVTDTETVPASESPGVMPLSLLRQMFSSYPTTTVLPTRRAQTPPISSLPTSPSDEVGRRQSLTSPDSQSARPANRTALSDPSSRLSTSPPPPAIAVPLLEMGFSLRQIAKAMEATGARGEADAQNITVLAMWMIEHPGHEDEEEPQSGSTADSRPGAAVLGSGGKSNDPCYLQSPGDIPSADAAEMEEGFSESPDNLDHTENAASGSGPSARGRSAVTRRHKFDLAARTLLARAAGLYRSVQAHRNQSRREGISLQQDPGALYDFNLDEELEIDLDDEAMEAMFGQDLTSDNDILGMWIPEVLDWPTWHVCESEDREEVVVCELCECSVVSFNQHMKRNHPGCGRSANRQGYRSNGSYVDGWFGGECGSGNPYYLLCGTCREKYLAMKTKSKSTSSERYKGQAPDLIGKQDSVYEEDWDMLDVDEDEKLTGEEEFELLAGPLGLNDRRIVPEPVQFPDSDPLGASVAMVTATNSMEETLMQIGCHGSVEKSSSGRITLGEQAAALANPHDRVVALRRVTAAAQVLLARTMVMRALSLLSVSGSSCSLAAGLESLGLTDIRTLVRLMCLAAAGRAGLSTSPSAMASTSERSRGGHSKANKPISCLAYLSTAVGCLASNAPSAAKLLVQLCTQNLISAATGVNLTTVDDSIQRKFLPSFLRGIAEENKLVTSPNFVVTQALVALLADKGAKLRPNYDKSEVEKKGPLELANALAACCLSSRLSSQHRQWAAQQLVRTLAAHDRDNQTTLQTLADMGGDLRKCSFIKLEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWNVTKKQYSLQQTCVFNRLEGDAEESLGSPSDPSFSPVSWSISGKYLAGALEKMVNIWQVNGGKGLVDIQPHWVSALAWPEEGPATAWSGESPELLLVGRMDGSLGLIEVVDVSTMHRRELEHCYRKDVSVTCIAWFSEDRPFAVGYFDGKLLLGTKEPLEKGGIVLIDAHKDTLISMKWDPTGHILMTCAKEDSVKLWGSISGCWCCLHSLCHPSIVNGIAWCRLPGKGSKLQLLMATGCQSGLVCVWRIPQDTTQTNVTSAEGWWEQESNCQDGYRKSSGAKCVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWSLRDGSVLQTVVIGSGAIQTTVWIPEVGVAACSNRSKDVLVVNCTAEWAAANHVLATCRTALKQQGVLGLNMAPCMRAFLERLPMMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWLECFSTTIKAAEALTNGAQFPESFTVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDTVPPQYGALREVSIHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTDY"},{"id":"SEQ_08157","a":"Q96AP0","g":"ACD","d":"Adrenocortical dysplasia protein homolog","L":458,"m":[{"c":"TP[RS][SL][PS]xxS[RCH]","u":9,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Three contiguous head-to-tail 9-residue repeats in the central Pro/Ser/Thr-rich disordered region anchored by invariant N-terminal TP and position-8 Ser residues alongside constrained [RS][SL][PS] core positions.","i":[[327,335,"TPRSPHASR"],[336,344,"TPSSPLQSC"],[345,353,"TPSLSPRSH"]]}],"s":"MAGSGRLVLRPWIRELILGSETPSSPRAGQLLEVLQDAEAAVAGPSHAPDTSDVGATLLVSDGTHSVRCLVTREALDTSDWEEKEFGFRGTEGRLLLLQDCGVHVQVAEGGAPAEFYLQVDRFSLLPTEQPRLRVPGCNQDLDVQKKLYDCLEEHLSESTSSNAGLSLSQLLDEMREDQEHQGALVCLAESCLTLEGPCTAPPVTHWAASRCKATGEAVYTVPSSMLCISENDQLILSSLGPCQRTQGPELPPPDPALQDLSLTLIASPPSSPSSSGTPALPGHMSSEESGTSISLLPALSLAAPDPGQRSSSQPSPAICSAPATLTPRSPHASRTPSSPLQSCTPSLSPRSHVPSPHQALVTRPQKPSLEFKEFVGLPCKNRPPFPRTGATRGAQEPCSVWEPPKRHRDGSAFQYEYEPPCTSLCARVQAVRLPPQLMAWALHFLMDAQPGSEPTPM"},{"id":"SEQ_08161","a":"Q9Y4B6","g":"DCAF1","d":"DDB1- and CUL4-associated factor 1","L":1507,"m":[{"c":"xx[FP][SNH]xxxxxxψxx[TAG](x){1,8}[LI][WY][DNG]ψx[ST]","u":"21-28","sp":"periodic","x":"structured_like","cf":"high","why":"Five periodic beta-propeller blade repeats in the C-terminal structured domain (residues 1099-1284) anchored by an N-terminal [FP][SNH] turn motif, a conserved central aliphatic strand residue (ψxx[TAG]), a short 1-8 aa loop, and a strongly conserved C-terminal [LI][WY][DNG]ψx[ST] motif.","i":[[1099,1124,"CAFSARERFLMLGTCTGQLKLYNVFS"],[1141,1168,"LEPSRDGSLLLTSATWSQPLSALWGMKS"],[1182,1207,"VEFSKHSQDRVIGTKGDIAHIYDIQT"],[1228,1248,"ATFNPTDDLVLNDGVLWDVRS"],[1264,1284,"GVFHPNGLEVIINTEIWDLRT"]]}],"s":"MTTVVVHVDSKAELTTLLEQWEKEHGSGQDMVPILTRMSQLIEKETEEYRKGDPDPFDDRHPGRADPECMLGHLLRILFKNDDFMNALVNAYVMTSREPPLNTAACRLLLDIMPGLETAVVFQEKEGIVENLFKWAREADQPLRTYSTGLLGGAMENQDIAANYRDENSQLVAIVLRRLRELQLQEVALRQENKRPSPRKLSSEPLLPLDEEAVDMDYGDMAVDVVDGDQEEASGDMEISFHLDSGHKTSSRVNSTTKPEDGGLKKNKSAKQGDRENFRKAKQKLGFSSSDPDRMFVELSNSSWSEMSPWVIGTNYTLYPMTPAIEQRLILQYLTPLGEYQELLPIFMQLGSRELMMFYIDLKQTNDVLLTFEALKHLASLLLHNKFATEFVAHGGVQKLLEIPRPSMAATGVSMCLYYLSYNQDAMERVCMHPHNVLSDVVNYTLWLMECSHASGCCHATMFFSICFSFRAVLELFDRYDGLRRLVNLISTLEILNLEDQGALLSDDEIFASRQTGKHTCMALRKYFEAHLAIKLEQVKQSLQRTEGGILVHPQPPYKACSYTHEQIVEMMEFLIEYGPAQLYWEPAEVFLKLSCVQLLLQLISIACNWKTYYARNDTVRFALDVLAILTVVPKIQLQLAESVDVLDEAGSTVSTVGISIILGVAEGEFFIHDAEIQKSALQIIINCVCGPDNRISSIGKFISGTPRRKLPQNPKSSEHTLAKMWNVVQSNNGIKVLLSLLSIKMPITDADQIRALACKALVGLSRSSTVRQIISKLPLFSSCQIQQLMKEPVLQDKRSDHVKFCKYAAELIERVSGKPLLIGTDVSLARLQKADVVAQSRISFPEKELLLLIRNHLISKGLGETATVLTKEADLPMTAASHSSAFTPVTAAASPVSLPRTPRIANGIATRLGSHAAVGASAPSAPTAHPQPRPPQGPLALPGPSYAGNSPLIGRISFIRERPSPCNGRKIRVLRQKSDHGAYSQSPAIKKQLDRHLPSPPTLDSIITEYLREQHARCKNPVATCPPFSLFTPHQCPEPKQRRQAPINFTSRLNRRASFPKYGGVDGGCFDRHLIFSRFRPISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATWSQPLSALWGMKSVFDMKHSFTEDHYVEFSKHSQDRVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLVLNDGVLWDVRSAQAIHKFDKFNMNISGVFHPNGLEVIINTEIWDLRTFHLLHTVPALDQCRVVFNHTGTVMYGAMLQADDEDDLMEERMKSPFGSSFRTFNATDYKPIATIDVKRNIFDLCTDTKDCYLAVIENQGSMDALNMDTVCRLYEVGRQRLAEDEDEEEDQEEEEQEEEDDDEDDDDTDDLDELDTDQLLEAELEEDDNNENAGEDGDNDFSPSDEELANLLEEGEDGEDEDSDADEEVELILGDTDSSDNSDLEDDIILSLNE"},{"id":"SEQ_08166","a":"Q9BXT6","g":"MOV10L1","d":"RNA helicase Mov10l1","L":1211,"m":[{"c":"[TR]V(x){3,4}ψ[TS]xxxxxxGxψxxx[IT][YF]F[ST][SL]-[AS]ψ(x){8,10}G[DQ]xVxA[VE][VY](x){17,20}φ","u":"63-64","sp":"dispersed","x":"structured_like","cf":"high","why":"Three N-terminal ~64-aa structured repeats anchored by an invariant Gxψxxx[IT][YF]F[ST][SL]-[AS]ψ core, an N-terminal [TR]V(x){3,4}ψ[TS] motif, and a C-terminal G[DQ]xVxA[VE][VY] motif; copy 1 is separated from the nearly head-to-tail copies 2-3 (1-aa gap) by a 16-aa linker.","i":[[39,102,"TVRGVVTRYCSDYGMIDDMIYFSSDAVTSRVLLNVGQEVIAVVEENKVSNGLKAIRVEAVSDKW"],[118,180,"RVLIGCVTSLVEGAGCISQTTYFSLESVCEGFEPCKGDWVEAEYRIRPGTWSSEATSVKPLRY"],[182,245,"RVDKVCISSLCGRNGVLEESIFFTLDSLKLPDGYTPRRGDVVNAVVVESSQSCYVWRALCMTLV"]]},{"c":"[TV]Iφψ[KE]NKGDIxxxxV[TS]xxxxxx-xxx[KQ]","u":27,"sp":"tandem","x":"structured_like","cf":"medium","why":"Two tandem 27-aa repeats separated by a 2-aa linker immediately C-terminal to the 64-aa repeat array, sharing an identical NKGDI pentapeptide flanked by conserved hydrophobic ([TV]Iφψ), aliphatic-polar (V[TS]), and acidic (-) positions.","i":[[262,288,"TILLKNKGDIEVTQVTHFGTLKEGRSK"],[291,317,"VIWIENKGDIPQNLVSCKLAGWDKSKQ"]]}],"s":"MLSLAAKLVAFFWRTADTPREEAGQLEPELAEGDTKLKTVRGVVTRYCSDYGMIDDMIYFSSDAVTSRVLLNVGQEVIAVVEENKVSNGLKAIRVEAVSDKWEDDSRNHGSPSDCGPRVLIGCVTSLVEGAGCISQTTYFSLESVCEGFEPCKGDWVEAEYRIRPGTWSSEATSVKPLRYKRVDKVCISSLCGRNGVLEESIFFTLDSLKLPDGYTPRRGDVVNAVVVESSQSCYVWRALCMTLVKRRDAAPVHEATHFYGTILLKNKGDIEVTQVTHFGTLKEGRSKTMVIWIENKGDIPQNLVSCKLAGWDKSKQFRFQMLDKDQMCPVVSFVSVPEKENSSDENINSLNSHTKNKTSQMSESSLVNNRGISPGDCTCKGENGEKDNILSRKQMTEPEPGGLVPPGGKTFIVVICDGKNPGRCKELLLLCFSDFLIGRYLEVNVISGEESLIAAREPFSWKKLKSSQALTSAKTTVVVTAQKRNSRRQLPSFLPQYPIPDRLRKCVEQKIDILTFQPLLAELLNMSNYKEKFSTLLWLEEIYAEMELKEYNMSGIILRRNGDLLVLEVPGLAEGRPSLYAGDKLILKTQEYNGHAIEYISYVTEIHEEDVTLKINPEFEQAYNFEPMDVEFTYNRTTSRRCHFALEHVIHLGVKVLFPEEIILQSPQVTGNWNHAQDTKSSGQSTSKKNRKTMTDQAEHGTEERRVGDKDLPVLAPFTAEMSDWVDEIQTPKARKMEFFNPVLNENQKLAVKRILSGDCRPLPYILFGPPGTGKTVTIIEAVLQVHFALPDSRILVCAPSNSAADLVCLRLHESKVLQPATMVRVNATCRFEEIVIDAVKPYCRDGEDIWKASRFRIIITTCSSSGLFYQIGVRVGHFTHVFVDEAGQASEPECLIPLGLMSDISGQIVLAGDPMQLGPVIKSRLAMAYGLNVSFLERLMSRPAYQRDENAFGACGAHNPLLVTKLVKNYRSHEALLMLPSRLFYHRELEVCADPTVVTSLLGWEKLPKKGFPLIFHGVRGSEAREGKSPSWFNPAEAVQVLRYCCLLAHSISSQVSASDIGVITPYRKQVEKIRILLRNVDLMDIKVGSVEEFQGQEYLVIIISTVRSNEDRFEDDRYFLGFLSNSKRFNVAITRPKALLIVLGNPHVLVRDPCFGALLEYSITNGVYMGCDLPPALQSLQNCGEGVADPSYPVVPESTGPEKHQEPS"},{"id":"SEQ_08169","a":"P08575","g":"PTPRC","d":"Receptor-type tyrosine-protein phosphatase C","L":1306,"m":[{"c":"AEFQ[SR]ψP[RS]φ[FR]SxxxxxxxxxxxN[QK][NS]KNRxxxψψPYDYNRV[EP]L(x){10,29}YINAS[YF]Ixxxx[EK]P[RE]xφIAAQGP[RL][DK]ETψ[DG]DFW[RQ]MI[WF][EQ][QR]K[AV][TK]VIVMψTxxxxxxxx[KI]CA[EQ]YW(x){7,10}GDψxVxxxxxxxxx[DT]Y[IT]ψxxφxψxxK[ER]K(x){4,5}V[TY][HQ]φQ[FY]T[SN]W[PS]xxxψP[EA]-P[HK][LE]Lψ[KS]ψxxxV[NK](x){8,18}PψψψHC[SR][AD]G[VS][GQ][RQ]TG[TI][YF]xxψxxψLExxExExxVDψ[YF]xxVxxLR+xRxxMV[QS][VT]xxQY[IQ]φψ[HY][QD][AV]ψ(x){2,3}Y","u":"258-284","sp":"dispersed","x":"structured_like","cf":"high","why":"Two large C-terminal structured domain repeats separated by a 33-aa linker, exhibiting extensive sequence conservation across multiple signature blocks including AEFQ, KNRxxxψψPYDYNRV[EP]L, YINAS[YF]I, IAAQGP...DFW...VIVMψT, CA[EQ]YW, and PψψψHCxxGxxxTG, with an acidic loop insertion in copy 2.","i":[[655,912,"AEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY"],[946,1229,"AEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTY"]]}],"s":"MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS"},{"id":"SEQ_08173","a":"Q96N67","g":"DOCK7","d":"Dedicator of cytokinesis protein 7","L":2140,"m":[{"c":"[ST][HY]xxxGFYG[TE]+FG(x){0,2}--xxxVφK-","u":"22-24","sp":"periodic","x":"structured_like","cf":"high","why":"Two adjacent 22-24 aa C-terminal structural repeats separated by a 9-aa linker, anchored by an invariant GFYG...FG aromatic-glycine core with a conserved basic residue, a 0-2 aa variable turn, a di-acidic pair, and a C-terminal VφK- motif.","i":[[1841,1864,"TYFRVGFYGTKFGDLDEQEFVYKE"],[1874,1895,"SHRLEGFYGERFGEDVVEVIKD"]]}],"s":"MAERRAFAQKISRTVAAEVRKQISGQYSGSPQLLKNLNIVGNISHHTTVPLTEAVDPVDLEDYLITHPLAVDSGPLRDLIEFPPDDIEVVYSPRDCRTLVSAVPEESEMDPHVRDCIRSYTEDWAIVIRKYHKLGTGFNPNTLDKQKERQKGLPKQVFESDEAPDGNSYQDDQDDLKRRSMSIDDTPRGSWACSIFDLKNSLPDALLPNLLDRTPNEEIDRQNDDQRKSNRHKELFALHPSPDEEEPIERLSVPDIPKEHFGQRLLVKCLSLKFEIEIEPIFASLALYDVKEKKKISENFYFDLNSEQMKGLLRPHVPPAAITTLARSAIFSITYPSQDVFLVIKLEKVLQQGDIGECAEPYMIFKEADATKNKEKLEKLKSQADQFCQRLGKYRMPFAWTAIHLMNIVSSAGSLERDSTEVEISTGERKGSWSERRNSSIVGRRSLERTTSGDDACNLTSFRPATLTVTNFFKQEGDRLSDEDLYKFLADMRRPSSVLRRLRPITAQLKIDISPAPENPHYCLTPELLQVKLYPDSRVRPTREILEFPARDVYVPNTTYRNLLYIYPQSLNFANRQGSARNITVKVQFMYGEDPSNAMPVIFGKSSCSEFSKEAYTAVVYHNRSPDFHEEIKVKLPATLTDHHHLLFTFYHVSCQQKQNTPLETPVGYTWIPMLQNGRLKTGQFCLPVSLEKPPQAYSVLSPEVPLPGMKWVDNHKGVFNVEVVAVSSIHTQDPYLDKFFALVNALDEHLFPVRIGDMRIMENNLENELKSSISALNSSQLEPVVRFLHLLLDKLILLVIRPPVIAGQIVNLGQASFEAMASIINRLHKNLEGNHDQHGRNSLLASYIHYVFRLPNTYPNSSSPGPGGLGGSVHYATMARSAVRPASLNLNRSRSLSNSNPDISGTPTSPDDEVRSIIGSKGLDRSNSWVNTGGPKAAPWGSNPSPSAESTQAMDRSCNRMSSHTETSSFLQTLTGRLPTKKLFHEELALQWVVCSGSVRESALQQAWFFFELMVKSMVHHLYFNDKLEAPRKSRFPERFMDDIAALVSTIASDIVSRFQKDTEMVERLNTSLAFFLNDLLSVMDRGFVFSLIKSCYKQVSSKLYSLPNPSVLVSLRLDFLRIICSHEHYVTLNLPCSLLTPPASPSPSVSSATSQSSGFSTNVQDQKIANMFELSVPFRQQHYLAGLVLTELAVILDPDAEGLFGLHKKVINMVHNLLSSHDSDPRYSDPQIKARVAMLYLPLIGIIMETVPQLYDFTETHNQRGRPICIATDDYESESGSMISQTVAMAIAGTSVPQLTRPGSFLLTSTSGRQHTTFSAESSRSLLICLLWVLKNADETVLQKWFTDLSVLQLNRLLDLLYLCVSCFEYKGKKVFERMNSLTFKKSKDMRAKLEEAILGSIGARQEMVRRSRGQLGTYTIASPPERSPSGSAFGSQENLRWRKDMTHWRQNTEKLDKSRAEIEHEALIDGNLATEANLIILDTLEIVVQTVSVTESKESILGGVLKVLLHSMACNQSAVYLQHCFATQRALVSKFPELLFEEETEQCADLCLRLLRHCSSSIGTIRSHASASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSQNFNEEFLRRSLKTILTYAEEDLELRETTFPDQVQDLVFNLHMILSDTVKMKEHQEDPEMLIDLMYRIAKGYQTSPDLRLTWLQNMAGKHSERSNHAEAAQCLVHSAALVAEYLSMLEDRKYLPVGCVTFQNISSNVLEESAVSDDVVSPDEEGICSGKYFTESGLVGLLEQAAASFSMAGMYEAVNEVYKVLIPIHEANRDAKKLSTIHGKLQEAFSKIVHQSTGWERMFGTYFRVGFYGTKFGDLDEQEFVYKEPAITKLAEISHRLEGFYGERFGEDVVEVIKDSNPVDKCKLDPNKAYIQITYVEPYFDTYEMKDRITYFDKNYNLRRFMYCTPFTLDGRAHGELHEQFKRKTILTTSHAFPYIKTRVNVTHKEEIILTPIEVAIEDMQKKTQELAFATHQDPADPKMLQMVLQGSVGTTVNQGPLEVAQVFLSEIPSDPKLFRHHNKLRLCFKDFTKRCEDALRKNKSLIGPDQKEYQRELERNYHRLKEALQPLINRKIPQLYKAVLPVTCHRDSFSRMSLRKMDL"},{"id":"SEQ_08184","a":"O75170","g":"PPP6R2","d":"Serine/threonine-protein 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2).","i":[[886,896,"VTAAPAVAVPP"],[918,928,"VSSALAVAVPL"],[934,944,"VTAAPAMVATL"]]}],"s":"MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDPPLDMEEKVRFKYPNTACELLTCDVPQISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGNLIARKTEQVITFLKKKDKFISLVLKHIGTSALMDLLLRLVSCVEPAGLRQDVLHWLNEEKVIQRLVELIHPSQDEDRQSNASQTLCDIVRLGRDQGSQLQEALEPDPLLTALESQDCVEQLLKNMFDGDRTESCLVSGTQVLLTLLETRRVGTEGLVDSFSQGLERSYAVSSSVLHGIEPRLKDFHQLLLNPPKKKAILTTIGVLEEPLGNARLHGARLMAALLHTNTPSINQELCRLNTMDLLLDLFFKYTWNNFLHFQVELCIAAILSHAAREERTEASGSESRVEPPHENGNRSLETPQPAASLPDNTMVTHLFQKCCLVQRILEAWEANDHTQAAGGMRRGNMGHLTRIANAVVQNLERGPVQTHISEVIRGLPADCRGRWESFVEETLTETNRRNTVDLVSTHHLHSSSEDEDIEGAFPNELSLQQAFSDYQIQQMTANFVDQFGFNDEEFADQDDNINAPFDRIAEINFNIDADEDSPSAALFEACCSDRIQPFDDDEDEDIWEDSDTRCAARVMARPRFGAPHASESCSKNGPERGGQDGKASLEAHRDAPGAGAPPAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGVVRDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGPEKASQASYFAVSPASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAASAMDAVSRGPGREAPPLPTVARTEEAVGRVGCADSRLLSPACPAPKEVTAAPAVAVPPEATVAITTALSKAGPAIPTPAVSSALAVAVPLGPIMAVTAAPAMVATLGTVTKDGKTDAPPEGAALNGPV"},{"id":"SEQ_08187","a":"P07814","g":"EPRS1","d":"Bifunctional glutamate/proline--tRNA ligase","L":1512,"m":[{"c":"L[YF][DN]xVAxQG-VVR[EK]LK[AT][EK]K[AS]PKxxψ[DN]xAVxxLL[SQ]LKA[EQ]YK[ES][KL][TI]GxEY[KI]P","u":49,"sp":"dispersed","x":"structured_like","cf":"high","why":"Three highly conserved 49-aa structured repeats in the central region separated by 24-aa and 29-aa polar/proline-rich linkers, anchored by invariant VAxQG-VVRxLK, a central PK turn, AVxxLL[SQ]LKA[EQ]YK, and C-terminal GxEY[KI]P.","i":[[753,801,"LYNRVAVQGDVVRELKAKKAPKEDVDAAVKQLLSLKAEYKEKTGQEYKP"],[826,874,"LYDEVAAQGEVVRKLKAEKSPKAKINEAVECLLSLKAQYKEKTGKEYIP"],[904,952,"LFDKVASQGEVVRKLKTEKAPKDQVDIAVQELLQLKAQYKSLIGVEYKP"]]}],"s":"MATLSLTVNSGDPPLGALLAVEHVKDDVSISVEEGKENILHVSENVIFTDVNSILRYLARVATTAGLYGSNLMEHTEIDHWLEFSATKLSSCDSFTSTINELNHCLSLRTYLVGNSLSLADLCVWATLKGNAAWQEQLKQKKAPVHVKRWFGFLEAQQAFQSVGTKWDVSTTKARVAPEKKQDVGKFVELPGAEMGKVTVRFPPEASGYLHIGHAKAALLNQHYQVNFKGKLIMRFDDTNPEKEKEDFEKVILEDVAMLHIKPDQFTYTSDHFETIMKYAEKLIQEGKAYVDDTPAEQMKAEREQRIDSKHRKNPIEKNLQMWEEMKKGSQFGQSCCLRAKIDMSSNNGCMRDPTLYRCKIQPHPRTGNKYNVYPTYDFACPIVDSIEGVTHALRTTEYHDRDEQFYWIIEALGIRKPYIWEYSRLNLNNTVLSKRKLTWFVNEGLVDGWDDPRFPTVRGVLRRGMTVEGLKQFIAAQGSSRSVVNMEWDKIWAFNKKVIDPVAPRYVALLKKEVIPVNVPEAQEEMKEVAKHPKNPEVGLKPVWYSPKVFIEGADAETFSEGEMVTFINWGNLNITKIHKNADGKIISLDAKLNLENKDYKKTTKVTWLAETTHALPIPVICVTYEHLITKPVLGKDEDFKQYVNKNSKHEELMLGDPCLKDLKKGDIIQLQRRGFFICDQPYEPVSPYSCKEAPCVLIYIPDGHTKEMPTSGSKEKTKVEATKNETSAPFKERPTPSLNNNCTTSEDSLVLYNRVAVQGDVVRELKAKKAPKEDVDAAVKQLLSLKAEYKEKTGQEYKPGNPPAEIGQNISSNSSASILESKSLYDEVAAQGEVVRKLKAEKSPKAKINEAVECLLSLKAQYKEKTGKEYIPGQPPLSQSSDSSPTRNSEPAGLETPEAKVLFDKVASQGEVVRKLKTEKAPKDQVDIAVQELLQLKAQYKSLIGVEYKPVSATGAEDKDKKKKEKENKSEKQNKPQKQNDGQRKDPSKNQGGGLSSSGAGEGQGPKKQTRLGLEAKKEENLADWYSQVITKSEMIEYHDISGCYILRPWAYAIWEAIKDFFDAEIKKLGVENCYFPMFVSQSALEKEKTHVADFAPEVAWVTRSGKTELAEPIAIRPTSETVMYPAYAKWVQSHRDLPIKLNQWCNVVRWEFKHPQPFLRTREFLWQEGHSAFATMEEAAEEVLQILDLYAQVYEELLAIPVVKGRKTEKEKFAGGDYTTTIEAFISASGRAIQGGTSHHLGQNFSKMFEIVFEDPKIPGEKQFAYQNSWGLTTRTIGVMTMVHGDNMGLVLPPRVACVQVVIIPCGITNALSEEDKEALIAKCNDYRRRLLSVNIRVRADLRDNYSPGWKFNHWELKGVPIRLEVGPRDMKSCQFVAVRRDTGEKLTVAENEAETKLQAILEDIQVTLFTRASEDLKTHMVVANTMEDFQKILDSGKIVQIPFCGEIDCEDWIKKTTARDQDLEPGAPSMGAKSLCIPFKPLCELQPGAKCVCGKNPAKYYTLFGRSY"},{"id":"SEQ_08195","a":"Q86TC9","g":"MYPN","d":"Myopalladin","L":1320,"m":[{"c":"Px[FI]xxx[LP]xxxx[VA]xEGxx[VC]x[LF][DET]Cx[VI]xGφP[PSV]PxφxWxx[DEN][GN]xxψxxxx[DES]xxxψ(x){5,13}[CHA][STC]LxIxxxxxxDxGx[YF][TSK][CIL]xAxNxxGxxSx[STI][AGL]x[LI]x[VI]","u":"90-98","sp":"dispersed","x":"structured_like","cf":"high","why":"Five 90-98 aa structured repeat units separated by variable linkers (8-412 aa), defined by invariant P, EG, C, GφP[PSV]P, W, LI, DxGx[YF], AxNxxGxxS anchors and conserved hydrophobic core positions flanking a short 5-13 aa central variable loop.","i":[[269,358,"PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI"],[435,532,"PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV"],[945,1036,"PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMV"],[1073,1163,"PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV"],[1172,1263,"PVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI"]]}],"s":"MQDDSIEASTSISQLLRESYLAETRHRGNNERSRAEPSSNPCHFGSPSGAAEGGGGQDDLPDLSAFLSQEELDESVNLARLAINYDPLEKADETQARKRLSPDQMKHSPNLSFEPNFCQDNPRSPTSSKESPQEAKRPQYCSETQSKKVFLNKAADFIEELSSLFKSHSSKRIRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSEASSEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQLQQLHNQVLLEQHQLQNPPPSSPKEFPFSMTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGGLSIQNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRPSGSRYGSLTSKGLDIFSAFSSMESTMVYSCSSRSVVESDEL"},{"id":"SEQ_08197","a":"Q8WYB5","g":"KAT6B","d":"Histone acetyltransferase KAT6B","L":2073,"m":[{"c":"S[ST]LxxNxxxK[GA]LφDGL[ST][KH]φΩTxo[GP]x[GS]R+","u":28,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Strongly conserved 28-aa internal duplication embedded in the N-terminal Ser/Thr/Pro-rich disordered region, sharing 10 identical anchors (S, L, N, K, L, D, G, L, T, R) and 11 physicochemically conserved positions including a 12-aa K[GA]LφDGL[ST][KH]φΩT amphipathic core.","i":[[423,450,"STLKVNKKTKGLIDGLTKFFTPSPDGRR"],[532,559,"SSLTTNSQLKALFDGLSHIYTTQGQSRK"]]},{"c":"PP[PM][NL]L","u":5,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Three tandem copies (separated by 2 and 0 aa within TPPPNLTPPPMNLPPPLL) in the C-terminal disordered region with a conserved N-terminal PP[PM] core anchored by a fixed C-terminal leucine.","i":[[1880,1884,"PPPNL"],[1887,1891,"PPMNL"],[1892,1896,"PPPLL"]]}],"s":"MVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGTFPKSAKGSRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYGSLDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCIECKTCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVTSDEGSMNAFTGRGSPGRGQKTKVCTTPSSGHAASGKDSSSRLAVTDPTRPGATTKITTTSTYISASTLKVNKKTKGLIDGLTKFFTPSPDGRRSRGEIIDFSKHYRPRKKVSQKQSCTSHVLATGTTQKLKPPPSSLPPPTPISGQSPSSQKSSTATSSPSPQSSSSQCSVPSLSSLTTNSQLKALFDGLSHIYTTQGQSRKKGHPSYAPPKRMRRKTELSSTAKSKAHFFGKRDIRSRFISHSSSSSWGMARGSIFKAIAHFKRTTFLKKHRMLGRLKYKVTPQMGTPSPGKGSLTDGRIKPDQDDDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQTWYSSPYPQEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVDGNMSKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTKNDEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQHQRQGFGRFLIDFSYLLSRREGQAGSPEKPLSDLGRLSYLAYWKSVILEYLYHHHERHISIKAISRATGMCPHDIATTLQHLHMIDKRDGRFVIIRREKLILSHMEKLKTCSRANELDPDSLRWTPILISNAAVSEEEREAEKEAERLMEQASCWEKEEQEILSTRANSRQSPAKVQSKNKYLHSPESRPVTGERGQLLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSPPRLTKPQSVAIKRKRPFVLKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMPQLEPTCEIEVEEDGRKPVLRKAFQHQPGKKRQTEEEEGKDNHCFKNADPCRNNMNDDSSNLKEGSKDNPEPLKCKQVWPKGTKRGLSKWRQNKERKTGFKLNLYTPPETPMEPDEQVTVEEQKETSEGKTSPSPIRIEEEVKETGEALLPQEENRREETCAPVSPNTSPGEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEELPRESFKEVLENQETFLDLNVQPGHSNPEVLMDCGVDLTASCNSEPKELAGDPEAVPESDEEPPPGEQAQKQDQKNSKEVDTEFKEGNPATMEIDSETVQAVQSLTQESSEQDDTFQDCAETQEACRSLQNYTRADQSPQIATTLDDCQQSDHSSPVSSVHSHPGQSVRSVNSPSVPALENSYAQISPDQSAISVPSLQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGNGSSQNSCSYSNLTSSSLTQSSCAVTQQMSNISGSCSMLQQTSISSPPTCSVKSPQGCVVERPPSSSQQLAQCSMAANFTPPMQLAEIPETSNANIGLYERMGQSDFGAGHYPQPSATFSLAKLQQLTNTLIDHSLPYSHSAAVTSYANSASLSTPLSNTGLVQLSQSPHSVPGGPQAQATMTPPPNLTPPPMNLPPPLLQRNMAASNIGISHSQRLQTQIASKGHISMRTKSASLSPAAATHQSQIYGRSQTVAMQGPARTLTMQRGMNMSVNLMPAPAYNVNSVNMNMNTLNAMNGYSMSQPMMNSGYHSNHGYMNQTPQYPMQMQMGMMGTQPYAQQPMQTPPHGNMMYTAPGHHGYMNTGMSKQSLNGSYMRR"},{"id":"SEQ_08214","a":"Q9UBZ9","g":"REV1","d":"Translesion synthesis protein REV1","L":1251,"m":[{"c":"[LF]xALP[AP]x[LS][QR]","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three non-overlapping 9-residue repeats within the C-terminal disordered region (residues 943-1029) anchored by an invariant ALP core, an N-terminal bulky hydrophobic [LF], and conserved downstream [AP]x[LS][QR] positions, with copies 1 and 3 also sharing wider flanking similarity.","i":[[943,951,"LEALPPDLR"],[1007,1015,"LIALPAFSQ"],[1021,1029,"FAALPAELQ"]]}],"s":"MRRGGWRKRAENDGWETWGGYMAAKVQKLEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYTDPSAEELRKLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVIRPEWIVESIKAGRLLSYIPYQLYTKQSSVQKGLSFNPVCRPEDPLPGPSNIAKQLNNRVNHIVKKIETENEVKVNGMNSWNEEDENNDFSFVDLEQTSPGRKQNGIPHPRGSTAIFNGHTPSSNGALKTQDCLVPMVNSVASRLSPAFSQEEDKAEKSSTDFRDCTLQQLQQSTRNTDALRNPHRTNSFSLSPLHSNTKINGAHHSTVQGPSSTKSTSSVSTFSKAAPSVPSKPSDCNFISNFYSHSRLHHISMWKCELTEFVNTLQRQSNGIFPGREKLKKMKTGRSALVVTDTGDMSVLNSPRHQSCIMHVDMDCFFVSVGIRNRPDLKGKPVAVTSNRGTGRAPLRPGANPQLEWQYYQNKILKGKAADIPDSSLWENPDSAQANGIDSVLSRAEIASCSYEARQLGIKNGMFFGHAKQLCPNLQAVPYDFHAYKEVAQTLYETLASYTHNIEAVSCDEALVDITEILAETKLTPDEFANAVRMEIKDQTKCAASVGIGSNILLARMATRKAKPDGQYHLKPEEVDDFIRGQLVTNLPGVGHSMESKLASLGIKTCGDLQYMTMAKLQKEFGPKTGQMLYRFCRGLDDRPVRTEKERKSVSAEINYGIRFTQPKEAEAFLLSLSEEIQRRLEATGMKGKRLTLKIMVRKPGAPVETAKFGGHGICDNIARTVTLDQATDNAKIIGKAMLNMFHTMKLNISDMRGVGIHVNQLVPTNLNPSTCPSRPSVQSSHFPSGSYSVRDVFQVQKAKKSTEEEHKEVFRAAVDLEISSASRTCTFLPPFPAHLPTSPDTNKAESSGKWNGLHTPVSVQSRLNLSIEVPSPSQLDQSVLEALPPDLREQVEQVCAVQQAESHGDKKKEPVNGCNTGILPQPVGTVLLQIPEPQESNSDAGINLIALPAFSQVDPEVFAALPAELQRELKAAYDQRQRQGENSTHQQSASASVPKNPLLHLKAAVKEKKRNKKKKTIGSPKRIQSPLNNKLLNSPAKTLPGACGSPQKLIDGFLKHEGPPAEKPLEELSASTSGVPGLSSLQSDPAGCVRPPAPNLAGAVEFNDVKTLLREWITTISDPMEEDILQVVKYCTDLIEEKDLEKLDLVIKYMKRLMQQSVESVWNMAFDFILDNVQVVLQQTYGSTLKVT"},{"id":"SEQ_08223","a":"Q9P2R6","g":"RERE","d":"Arginine-glutamic acid dipeptide repeats protein","L":1566,"m":[{"c":"[IL]RER[EM]","u":5,"sp":"tandem","x":"mixed","cf":"high","why":"Five contiguous head-to-tail pentapeptide repeats (residues 1299-1323, bracketed by DPT and KPG) anchored at position 1 by bulky aliphatic [IL] followed by an invariant R-E-R triad and C-terminal E (diverging to M in the terminal copy). Unlike the unanchored E/K/R-rich single alpha-helical rod flagged at residues 1160-1208, this array maintains a strict 5-residue periodicity anchored by Ile/Leu.","i":[[1299,1303,"IRERE"],[1304,1308,"LRERE"],[1309,1313,"IRERE"],[1314,1318,"IRERE"],[1319,1323,"LRERM"]]}],"s":"MTADKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLEGGAKNYAESDHSEDEDNDNNSATAEESTKKNKKKPPKKKSRYERTDTGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPALCDPPACSLPVASQPPQHLSEAGRGPVGSKRDHLLMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTYHAAALRGKCNISHFSDIFAAREFKARVDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCDLLMYLRAARSMAAFAGMCDGGSTEDGCVAASRDDTTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKCWTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTPEAASSRAHRRHRRQAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFYMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPAANPMEHFARHSALTIPPTAGPHPFASFHPGLNPLERERLALAGPQLRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSAGPVHPLVDPLTAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGAIPPPMSAAHQLQAMHAQSAELQRLAMEQQWLHGHPHMHGGHLPSQEDYYSRLKKEGDKQL"},{"id":"SEQ_08232","a":"Q8NEZ4","g":"KMT2C","d":"Histone-lysine N-methyltransferase 2C","L":4911,"m":[{"c":"[DV]PYxxxxxTP[RH][PS]","u":12,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Ten conserved 12-residue repeats in the central proline/serine/glutamine-rich disordered region (residues 1897-2309) anchored by invariant P2, Y3, T9, and P10 alongside strongly constrained [DV]1, [RH]11, and [PS]12 positions and frequent PP dipeptides in the central linker (with two additional diverged DSY variants nearby).","i":[[1896,1907,"DPYAKMVGTPRP"],[1961,1972,"DPYAKPPDTPRP"],[2070,2081,"DPYERPALTPRP"],[2092,2103,"DPYSQPPLTPHP"],[2129,2140,"DPYSQPPGTPRP"],[2157,2168,"DPYSQPPGTPRP"],[2172,2183,"DPYSQQPQTPRP"],[2201,2212,"DPYAHPPGTPRP"],[2216,2227,"VPYSQPPATPRP"],[2297,2308,"DPYDQSPMTPRS"]]},{"c":"CxxC(x){9,11}φφCxxCxxxYHxφCψ(x){10,11}GW[QKR]CxxC","u":"45-48","sp":"dispersed","x":"structured_like","cf":"high","why":"Four 45-48 aa cysteine-rich structured repeats arranged as two head-to-tail tandem pairs (2 aa intra-pair gap) separated by a ~522 aa disordered region, conserving seven cysteines, an invariant YH dipeptide, hydrophobic loop anchors, and a C-terminal GW[QKR]CxxC motif.","i":[[344,388,"CAVCDSPGDLLDQFFCTTCGQHYHGMCLDIAVTPLKRAGWQCPEC"],[391,435,"CQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNC"],[960,1007,"CVVCGSFGQGAEGRLLACSQCGQCYHPYCVSIKITKVVLSKGWRCLEC"],[1010,1054,"CEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWC"]]},{"c":"C[AV]FC[KH][HK]xGATxxCxxxxCToψYHΩ[PT]CA(x){13,14}LCP[EM]H","u":"45-46","sp":"dispersed","x":"structured_like","cf":"high","why":"Two highly conserved 45-46 aa cysteine/histidine-rich structured modules near the N- and C-terminal regions (residues 287-332 and 4462-4506) sharing 18 identical anchor positions including C[AV]FC, GAT, CT..YH..CA, and LCP[EM]H.","i":[[285,330,"CAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEH"],[4462,4506,"CVFCHKTGATSGCHRFRCTNIYHFTCAIKAQCMFFKDKTMLCPMH"]]},{"c":"CP[FV]CxxxY(x){8,10}CxxC[KD]RW[VM]HxxC(x){17,18}C[MS][YM]C","u":"50-51","sp":"dispersed","x":"structured_like","cf":"high","why":"Two non-overlapping 50-51 aa cysteine-rich structured modules located immediately C-terminal to each tandem pair of GW-containing repeats, anchored by seven conserved cysteines, an N-terminal CP[FV]CxxxY motif, a central CxxC[KD]RW[VM]HxxC core, and a C-terminal C[MS][YM]C motif.","i":[[467,517,"CPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYC"],[1087,1136,"CPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMC"]]}],"s":"MSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIKEQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDNSNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQMEEPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQFFCTTCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSSSQWHHNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIAELTTDYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVDSEDLKMSSEVKHICGEDQIEDKMEVTENIEVVTHQITVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLVIERLQGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKADVSSSPTPSSDLPSHDMLHNYPSALSSSAGNIMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRPRGAGLSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHPYCVSIKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYTQCAPCASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVPSSDCCESSLVAQIVTKVKELDPPKTYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREAVDDETKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDGWSEQLPDTLVDESVSVTESTEKIKKRYRKRKNKLEETFPAYLQEAFFGKDLLDTSRQSKISLDNLSEDGAQLLYKTNMNTGFLDPSLDPLLSSSSAPTKSGTHGPADDPLADISEVLNTDDDILGIISDDLAKSVDHSDIGPVTDDPSSLPQPNVNQSSRPLSEEQLDGILSPELDKMVTDGAILGKLYKIPELGGKDVEDLFTAVLSPANTQPTPLPQPPPPTQLLPIHNQDAFSRMPLMNGLIGSSPHLPHNSLPPGSGLGTFSAIAQSSYPDARDKNSAFNPMASDPNNSWTSSAPTVEGENDTMSNAQRSTLKWEKEEALGEMATVAPVLYTNINFPNLKEEFPDWTTRVKQIAKLWRKASSQERAPYVQKARDNRAALRINKVQMSNDSMKRQQQQDSIDPSSRIDSELFKDPLKQRESEHEQEWKFRQQMRQKSKQQAKIEATQKLEQVKNEQQQQQQQQFGSQHLLVQSGSDTPSSGIQSPLTPQPGNGNMSPAQSFHKELFTKQPPSTPTSTSSDDVFVKPQAPPPPPAPSRIPIQDSLSQAQTSQPPSPQVFSPGSSNSRPPSPMDPYAKMVGTPRPPPVGHSFSRRNSAAPVENCTPLSSVSRPLQMNETTANRPSPVRDLCSSSTTNNDPYAKPPDTPRPVMTDQFPKSLGLSRSPVVSEQTAKGPIAAGTSDHFTKPSPRADVFQRQRIPDSYARPLLTPAPLDSGPGPFKTPMQPPPSSQDPYGSVSQASRRLSVDPYERPALTPRPIDNFSHNQSNDPYSQPPLTPHPAVNESFAHPSRAFSQPGTISRPTSQDPYSQPPGTPRPVVDSYSQSSGTARSNTDPYSQPPGTPRPTTVDPYSQQPQTPRPSTQTDLFVTPVTNQRHSDPYAHPPGTPRPGISVPYSQPPATPRPRISEGFTRSSMTRPVLMPNQDPFLQAAQNRGPALPGPLVRPPDTCSQTPRPPGPGLSDTFSRVSPSAARDPYDQSPMTPRSQSDSFGTSQTAHDVADQPRPGSEGSFCASSNSPMHSQGQQFSGVSQLPGPVPTSGVTDTQNTVNMAQADTEKLRQRQKLREIILQQQQQKKIAGRQEKGSQDSPAVPHPGPLQHWQPENVNQAFTRPPPPYPGNIRSPVAPPLGPRYAVFPKDQRGPYPPDVASMGMRPHGFRFGFPGGSHGTMPSQERFLVPPQQIQGSGVSPQLRRSVSVDMPRPLNNSQMNNPVGLPQHFSPQSLPVQQHNILGQAYIELRHRAPDGRQRLPFSAPPGSVVEASSNLRHGNFIPRPDFPGPRHTDPMRRPPQGLPNQLPVHPDLEQVPPSQQEQGHSVHSSSMVMRTLNHPLGGEFSEAPLSTSVPSETTSDNLQITTQPSDGLEEKLDSDDPSVKELDVKDLEGVEVKDLDDEDLENLNLDTEDGKVVELDTLDNLETNDPNLDDLLRSGEFDIIAYTDPELDMGDKKSMFNEELDLPIDDKLDNQCVSVEPKKKEQENKTLVLSDKHSPQKKSTVTNEVKTEVLSPNSKVESKCETEKNDENKDNVDTPCSQASAHSDLNDGEKTSLHPCDPDLFEKRTNRETAGPSANVIQASTQLPAQDVINSCGITGSTPVLSSLLANEKSDNSDIRPSGSPPPPTLPASPSNHVSSLPPFIAPPGRVLDNAMNSNVTVVSRVNHVFSQGVQVNPGLIPGQSTVNHSLGTGKPATQTGPQTSQSGTSSMSGPQQLMIPQTLAQQNRERPLLLEEQPLLLQDLLDQERQEQQQQRQMQAMIRQRSEPFFPNIDFDAITDPIMKAKMVALKGINKVMAQNNLGMPPMVMSRFPFMGQVVTGTQNSEGQNLGPQAIPQDGSITHQISRPNPPNFGPGFVNDSQRKQYEEWLQETQQLLQMQQKYLEEQIGAHRKSKKALSAKQRTAKKAGREFPEEDAEQLKHVTEQQSMVQKQLEQIRKQQKEHAELIEDYRIKQQQQCAMAPPTMMPSVQPQPPLIPGATPPTMSQPTFPMVPQQLQHQQHTTVISGHTSPVRMPSLPGWQPNSAPAHLPLNPPRIQPPIAQLPIKTCTPAPGTVSNANPQSGPPPRVEFDDNNPFSESFQERERKERLREQQERQRIQLMQEVDRQRALQQRMEMEQHGMVGSEISSSRTSVSQIPFYSSDLPCDFMQPLGPLQQSPQHQQQMGQVLQQQNIQQGSINSPSTQTFMQTNERRQVGPPSFVPDSPSIPVGSPNFSSVKQGHGNLSGTSFQQSPVRPSFTPALPAAPPVANSSLPCGQDSTITHGHSYPGSTQSLIQLYSDIIPEEKGKKKRTRKKKRDDDAESTKAPSTPHSDITAPPTPGISETTSTPAVSTPSELPQQADQESVEPVGPSTPNMAAGQLCTELENKLPNSDFSQATPNQQTYANSEVDKLSMETPAKTEEIKLEKAETESCPGQEEPKLEEQNGSKVEGNAVACPVSSAQSPPHSAGAPAAKGDSGNELLKHLLKNKKSSSLLNQKPEGSICSEDDCTKDNKLVEKQNPAEGLQTLGAQMQGGFGCGNQLPKTDGGSETKKQRSKRTQRTGEKAAPRSKKRKKDEEEKQAMYSSTDTFTHLKQQNNLSNPPTPPASLPPTPPPMACQKMANGFATTEELAGKAGVLVSHEVTKTLGPKPFQLPFRPQDDLLARALAQGPKTVDVPASLPTPPHNNQEELRIQDHCGDRDTPDSFVPSSSPESVVGVEVSRYPDLSLVKEEPPEPVPSPIIPILPSTAGKSSESRRNDIKTEPGTLYFASPFGPSPNGPRSGLISVAITLHPTAAENISSVVAAFSDLLHVRIPNSYEVSSAPDVPSMGLVSSHRINPGLEYRQHLLLRGPPPGSANPPRLVSSYRLKQPNVPFPPTSNGLSGYKDSSHGIAESAALRPQWCCHCKVVILGSGVRKSFKDLTLLNKDSRESTKRVEKDIVFCSNNCFILYSSTAQAKNSENKESIPSLPQSPMRETPSKAFHQYSNNISTLDVHCLPQLPEKASPPASPPIAFPPAFEAAQVEAKPDELKVTVKLKPRLRAVHGGFEDCRPLNKKWRGMKWKKWSIHIVIPKGTFKPPCEDEIDEFLKKLGTSLKPDPVPKDYRKCCFCHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVYETQAGALINVELALRRGLQMKCVFCHKTGATSGCHRFRCTNIYHFTCAIKAQCMFFKDKTMLCPMHKPKGIHEQELSYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHTIGQLLPQQMQAFHSPKALFPVGYEASRLYWSTRYANRRCRYLCSIEEKDGRPVFVIRIVEQGHEDLVLSDISPKGVWDKILEPVACVRKKSEMLQLFPAYLKGEDLFGLTVSAVARIAESLPGVEACENYTFRYGRNPLMELPLAVNPTGCARSEPKMSAHVKRFVLRPHTLNSTSTSKSFQSTVTGELNAPYSKQFVHSKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCVAEVVTFERGHKIIISSSRRIQKGEELCYDYKFDFEDDQHKIPCHCGAVNCRKWMN"},{"id":"SEQ_08265","a":"Q86XP3","g":"DDX42","d":"ATP-dependent RNA helicase DDX42","L":938,"m":[{"c":"RHx-[GSN]","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Seven clustered 5-residue repeats in the C-terminal Arg/His/Gly/Ser-rich disordered tail anchored by an invariant N-terminal RH dipeptide, a conserved acidic residue (D/E) at position 4, and a small polar residue (G/S/N) at position 5, separated by short 1-7 residue linkers (including two additional degenerate RH[SG][HG][GS] copies within the same array).","i":[[827,831,"RHSDS"],[833,837,"RHGDG"],[839,843,"RHGDG"],[845,849,"RHPES"],[852,856,"RHTDG"],[858,862,"RHGEN"],[870,874,"RHGEN"]]}],"s":"MNWNKGGPGTKRGFGFGGFAISAGKKEEPKLPQQSHSAFGATSSSSGFGKSAPPQLPSFYKIGSKRANFDEENAYFEDEEEDSSNVDLPYIPAENSPTRQQFHSKPVDSDSDDDPLEAFMAEVEDQAARDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYMAENPTAGVVQEEEEDNLEYDSDGNPIAPTKKIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTPIQCQGVPVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELEPGDGPIAVIVCPTRELCQQIHAECKRFGKAYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNNNVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGFGNTGNISGAPVTYPSAGAQGVNNTASGNNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDGHRHGENRHGGSAGRHGENRGANDGRNGESRKEAFNRESKMEPKMEPKVDSSKMDKVDSKTDKTADGFAVPEPPKRKKSRWDS"},{"id":"SEQ_08269","a":"Q9H3U7","g":"SMOC2","d":"SPARC-related modular calcium-binding protein 2","L":446,"m":[{"c":"V[FV]IPECxxxGxYxxVQCHxxTGYCWCV(x){2,3}oGRPI[SP]GTxxxxxoP+C","u":"46-47","sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 46-47 aa cysteine-rich structured domains separated by an 81-residue linker, sharing five invariant cysteines and extensive multi-position sequence identity (V[FV]IPEC, VQCH, TGYCWCV, GRPI[SP]GT, and C-terminal P+C) across a minor 2-3 residue internal loop.","i":[[108,153,"VFIPECNDDGTYSQVQCHSYTGYCWCVTPNGRPISGTAVAHKTPRC"],[235,281,"VVIPECAHGGLYKPVQCHPSTGYCWCVLVDTGRPIPGTSTRYEQPKC"]]}],"s":"MLLPQLCWLPLLAGLLPPVPAQKFSALTFLRVDQDKDKDCSLDCAGSPQKPLCASDGRTFLSRCEFQRAKCKDPQLEIAYRGNCKDVSRCVAERKYTQEQARKEFQQVFIPECNDDGTYSQVQCHSYTGYCWCVTPNGRPISGTAVAHKTPRCPGSVNEKLPQREGTGKTDDAAAPALETQPQGDEEDIASRYPTLWTEQVKSRQNKTNKNSVSSCDQEHQSALEEAKQPKNDNVVIPECAHGGLYKPVQCHPSTGYCWCVLVDTGRPIPGTSTRYEQPKCDNTARAHPAKARDLYKGRQLQGCPGAKKHEFLTSVLDALSTDMVHAASDPSSSSGRLSEPDPSHTLEERVVHWYFKLLDKNSSGDIGKKEIKPFKRFLRKKSKPKKCVKKFVEYCDVNNDKSISVQELMGCLGVAKEDGKADTKKRHTPRGHAESTSNRQPRKQG"},{"id":"SEQ_08272","a":"Q9BXP5","g":"SRRT","d":"Serrate RNA effector molecule homolog","L":876,"m":[{"c":"-[YW]DRxR","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Four dispersed 6-aa copies in the N-terminal disordered region (residues 7-62, separated by 9-14 aa linkers) anchored by an acidic-aromatic -[YW] pair followed by invariant D and R-x-R positions; medium confidence due to surrounding R/D/E compositional bias.","i":[[7,12,"EYDRRR"],[22,27,"DYDRSR"],[42,47,"EWDRGR"],[57,62,"DYDRNR"]]}],"s":"MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDRNRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDVHIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWNLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWASEPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVERDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKKFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQILPPGLTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFRGQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF"},{"id":"SEQ_08276","a":"Q8NDV7","g":"TNRC6A","d":"Trinucleotide repeat-containing gene 6A protein","L":1962,"m":[{"c":"[GSP][TGS]xxWGx[PS]","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Dispersed 8-aa tryptophan-glycine motif occurring across S/T/G/P-rich disordered regions, anchored by an invariant WG dipeptide flanked N-terminally by [GSP][TGS] and C-terminally by [PS] at +2 after G (with predominantly acidic/polar residues at +1 and several additional degenerate GW/WG variants nearby).","i":[[309,316,"STGPWGFS"],[749,756,"GTEAWGSS"],[918,925,"PSQGWGDP"],[1004,1011,"GTSAWGDP"],[1056,1063,"SGSGWGEP"],[1077,1084,"GTSAWGKP"],[1087,1094,"SGPSWGEP"],[1100,1107,"STSTWGSS"],[1767,1774,"PGSSWGES"],[1915,1922,"GTSLWGTP"],[1925,1932,"STSLWGPP"]]}],"s":"MRELEAKATKDVERNLSRDLVQEEEQLMEEKKKKKDDKKKKEAAQKKATEQKIKVPEQIKPSVSQPQPANSNNGTSTATSTNNNAKRATANNQQPQQQQQQQQPQQQQPQQQPQPQPQQQQPQQQPQALPRYPREVPPRFRHQEHKQLLKRGQHFPVIAANLGSAVKVLNSQSESSALTNQQPQNNGEVQNSKNQSDINHSTSGSHYENSQRGPVSSTSDSSTNCKNAVVSDLSEKEAWPSAPGSDPELASECMDADSASSSESERNITIMASGNTGGEKDGLRNSTGLGSQNKFVVGSSSNNVGHGSSTGPWGFSHGAIISTCQVSVDAPESKSESSNNRMNAWGTVSSSSNGGLNPSTLNSASNHGAWPVLENNGLALKGPVGSGSSGINIQCSTIGQMPNNQSINSKVSGGSTHGTWGSLQETCESEVSGTQKVSFSGQPQNITTEMTGPNNTTNFMTSSLPNSGSVQNNELPSSNTGAWRVSTMNHPQMQAPSGMNGTSLSHLSNGESKSGGSYGTTWGAYGSNYSGDKCSGPNGQANGDTVNATLMQPGVNGPMGTNFQVNTNKGGGVWESGAANSQSTSWGSGNGANSGGSRRGWGTPAQNTGTNLPSVEWNKLPSNQHSNDSANGNGKTFTNGWKSTEEEDQGSATSQTNEQSSVWAKTGGTVESDGSTESTGRLEEKGTGESQSRDRRKIDQHTLLQSIVNRTDLDPRVLSNSGWGQTPIKQNTAWDTETSPRGERKTDNGTEAWGSSATQTFNSGACIDKTSPNGNDTSSVSGWGDPKPALRWGDSKGSNCQGGWEDDSAATGMVKSNQWGNCKEEKAAWNDSQKNKQGWGDGQKSSQGWSVSASDNWGETSRNNHWGEANKKSSSGGSDSDRSVSGWNELGKTSSFTWGNNINPNNSSGWDESSKPTPSQGWGDPPKSNQSLGWGDSSKPVSSPDWNKQQDIVGSWGIPPATGKPPGTGWLGGPIPAPAKEEEPTGWEEPSPESIRRKMEIDDGTSAWGDPSKYNYKNVNMWNKNVPNGNSRSDQQAQVHQLLTPASAISNKEASSGSGWGEPWGEPSTPATTVDNGTSAWGKPIDSGPSWGEPIAAASSTSTWGSSSVGPQALSKSGPKSMQDGWCGDDMPLPGNRPTGWEEEEDVEIGMWNSNSSQELNSSLNWPPYTKKMSSKGLSGKKRRRERGMMKGGNKQEEAWINPFVKQFSNISFSRDSPEENVQSNKMDLSGGMLQDKRMEIDKHSLNIGDYNRTVGKGPGSRPQISKESSMERNPYFDKDGIVADESQNMQFMSSQSMKLPPSNSALPNQALGSIAGLGMQNLNSVRQNGNPSMFGVGNTAAQPRGMQQPPAQPLSSSQPNLRAQVPPPLLSPQVPVSLLKYAPNNGGLNPLFGPQQVAMLNQLSQLNQLSQISQLQRLLAQQQRAQSQRSVPSGNRPQQDQQGRPLSVQQQMMQQSRQLDPNLLVKQQTPPSQQQPLHQPAMKSFLDNVMPHTTPELQKGPSPINAFSNFPIGLNSNLNVNMDMNSIKEPQSRLRKWTTVDSISVNTSLDQNSSKHGAISSGFRLEESPFVPYDFMNSSTSPASPPGSIGDGWPRAKSPNGSSSVNWPPEFRPGEPWKGYPNIDPETDPYVTPGSVINNLSINTVREVDHLRDRNSGSSSSLNTTLPSTSAWSSIRASNYNVPLSSTAQSTSARNSDSKLTWSPGSVTNTSLAHELWKVPLPPKNITAPSRPPPGLTGQKPPLSTWDNSPLRIGGGWGNSDARYTPGSSWGESSSGRITNWLVLKNLTPQIDGSTLRTLCMQHGPLITFHLNLPHGNALVRYSSKEEVVKAQKSLHMCVLGNTTILAEFASEEEISRFFAQSQSLTPSPGWQSLGSSQSRLGSLDCSHSFSSRTDLNHWNGAGLSGTNCGDLHGTSLWGTPHYSTSLWGPPSSSDPRGISSPSPINAFLSVDHLGGGGESM"},{"id":"SEQ_08283","a":"Q9P2P5","g":"HECW2","d":"E3 ubiquitin-protein ligase HECW2","L":1572,"m":[{"c":"LPxxWEφ+xDx[HQ]G+φFΩVDHxoRTTTΩxxPxφP","u":33,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two highly conserved 33-aa structured domain repeats separated by a 145-aa linker, sharing 16 identical anchor positions (LP, WE, D, G, F, VDH, RTTT, and C-terminal PxφP prolines) alongside conserved aromatic (Ω), hydrophobic (φ), polar (o), and basic (+) positions.","i":[[809,841,"LPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAP"],[987,1019,"LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLP"]]}],"s":"MASSAREHLLFVRRRNPQMRYTLSPENLQSLAAQSSMPENMTLQRANSDTDLVTSESRSSLTASMYEYTLGQAQNLIIFWDIKEEVDPSDWIGLYHIDENSPANFWDSKNRGVTGTQKGQIVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITVKNPAVMMGAEGMEGGASGNLHSRKLVSFTLSDLRAVGLKKGMFFNPDPYLKMSIQPGKKSSFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLTDVLEIEIKDKFAKSRPIIKRFLGKLTIPVQRLLERQAIGDQMLSYNLGRRLPADHVSGYLQFKVEVTSSVHEDASPEAVGTILGVNSVNGDLGSPSDDEDMPGSHHDSQVCSNGPVSEDSAADGTPKHSFRTSSTLEIDTEELTSTSSRTSPPRGRQDSLNDYLDAIEHNGHSRPGTATCSERSMGASPKLRSSFPTDTRLNAMLHIDSDEEDHEFQQDLGYPSSLEEEGGLIMFSRASRADDGSLTSQTKLEDNPVENEEASTHEAASFEDKPENLPELAESSLPAGPAPEEGEGGPEPQPSADQGSAELCGSQEVDQPTSGADTGTSDASGGSRRAVSETESLDQGSEPSQVSSETEPSDPARTESVSEASTRPEGESDLECADSSCNESVTTQLSSVDTRCSSLESARFPETPAFSSQEEEDGACAAEPTSSGPAEGSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGSLEGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVSRYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLLLQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVHRQHLTRQRSHSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYNDKIVAFLRQPNIFEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE"},{"id":"SEQ_08290","a":"P16403","g":"H1-2","d":"Histone H1.2","L":213,"m":[{"c":"[ST]PKK[SA][AK]","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three 6-aa repeats in the C-terminal disordered tail anchored by an invariant PKK core preceded by a conserved polar [ST] residue (scarce in the surrounding K/A/P-rich tail) and followed by [SA][AK].","i":[[146,151,"TPKKSA"],[154,159,"TPKKAK"],[173,178,"SPKKAK"]]},{"c":"[AV]xKPKKAA","u":8,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three non-overlapping 8-aa repeats in the C-terminal disordered tail sharing an invariant KPKKAA hexapeptide core and a conserved N-terminal aliphatic [AV] residue.","i":[[135,142,"AKKPKKAA"],[179,186,"VAKPKKAA"],[202,209,"VVKPKKAA"]]}],"s":"MSETAPAAPAAAPPAEKAPVKKKAAKKAGGTPRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKVKKAGGTKPKKPVGAAKKPKKAAGGATPKKSAKKTPKKAKKPAAATVTKKVAKSPKKAKVAKPKKAAKSAAKAVKPKAAKPKVVKPKKAAPKKK"},{"id":"SEQ_08292","a":"Q05215","g":"EGR4","d":"Early growth response protein 4","L":589,"m":[{"c":"K[AP]F[AQ]C(x){2,4}CxRF[AS]RSD[EH][LK]x[RT]Hx+[ITV]H[TL]","u":"26-28","sp":"tandem","x":"structured_like","cf":"high","why":"Three tandem 26-28 aa C-terminal repeats separated by 2-aa G[HE] linkers, strongly anchored by invariant K, F, C-(x){2,4}-C, RF, RSD, and H-x-+-x-H positions.","i":[[481,508,"KAFACPVESCVRSFARSDELNRHLRIHT"],[511,536,"KPFQCRICLRNFSRSDHLTTHVRTHT"],[539,564,"KPFACDVCGRRFARSDEKKRHSKVHL"]]}],"s":"MAVARGVGSPEPAPPQLYKWGGCGLGEPGSALERRGAAARGRCGRARAPRLPDSFPRGECPKPGARAPRSVRCGEPLPPASPPPARPQAQRARPRAPHSRRRAMLHLSEFSEPDALLVKSTEGCCAEPSAELPRLPARDAPAATGYPGAGDFLSWALNSCGASGDLADSCFLEGPAPTPPPGLSYSGSFFIQAVPEHPHDPEALFNLMSGILGLAPFPGPEAAASRSPLDAPFPAGSDALLPGPPDLYSPDLGAAPFPEAFWEASPCAGAPSQCLYEPQLSPPDVKPGLRAPPASPALDAVSAFKGPYAPWELLSVGAPGNCGSQGDYQAAPEARFPVIGTKIEDLLSISCPAELPAVPANRLYPSGAYDAFPLAPGDLGEGAEGLPGLLTPPSGEGGSSGDGGEFLASTQPQLSPLGLRSAAAADFPKPLVADIPGSSGVAAPPVPPPPPTPFPQAKARRKGRRGGKCSTRCFCPRPHAKAFACPVESCVRSFARSDELNRHLRIHTGHKPFQCRICLRNFSRSDHLTTHVRTHTGEKPFACDVCGRRFARSDEKKRHSKVHLKQKARAEERLKGLGFYSLGLSFASL"},{"id":"SEQ_08307","a":"Q9NSV4","g":"DIAPH3","d":"Protein diaphanous homolog 3","L":1193,"m":[{"c":"PPPPPL[PG]","u":7,"sp":"periodic","x":"disordered_like","cf":"medium","why":"Three periodic 7-aa motifs in the central proline/glycine-rich disordered linker separated by 10-11 aa spacers, each anchored at the C-terminus of a pentaproline run by an invariant L followed by [PG].","i":[[576,582,"PPPPPLP"],[594,600,"PPPPPLP"],[611,617,"PPPPPLG"]]}],"s":"MERHQPRLHHPAQGSAAGTPYPSSASLRGCRESKMPRRKGPQHPPPPSGPEEPGEKRPKFHLNIRTLTDDMLDKFASIRIPGSKKERPPLPNLKTAFASSDCSAAPLEMMENFPKPLSENELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYINTASKTGSLKRSRQISPQEFIHELKMGSADERLVTCLESLRVSLTSNPVSWVESFGHEGLGLLLDILEKLISGKIQEKVVKKNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRFFCIVEGLRHNSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLEEFEEKASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVESNRKKETELLGSFSKNESVPEVEALLARLRAL"},{"id":"SEQ_08309","a":"Q8NEN9","g":"PDZD8","d":"PDZ domain-containing protein 8","L":1154,"m":[{"c":"TW(x){8,13}WT+xxxoCψFxφxφCH(x){13,34}C[LG]AT(x){4,6}[YT]L[SK][KN]LRLE","u":"57-81","sp":"dispersed","x":"structured_like","cf":"high","why":"Two dispersed copies of a long cysteine-rich structured domain sharing an N-terminal TW anchor, a conserved 16-residue WT+xxxoCψFxφxφCH core, and a C-terminal C[LG]AT(x){4,6}[YT]L[SK][KN]LRLE motif separated by a variable-length internal cysteine-containing segment.","i":[[678,758,"TWESSEILYRNKLGKWTRTRASCLFDIEACHRYLNIALWCRDPFKLGGLICLGHVSLKLEDVALGCLATSNTEYLSKLRLE"],[852,908,"TWCDYCKKKVWTKAASQCMFCAYVCHKKCQEKCLAETSVCGATDRRIDRTLKNLRLE"]]}],"s":"MGLLLMILASAVLGSFLTLLAQFFLLYRRQPEPPADEAARAGEGFRYIKPVPGLLLREYLYGGGRDEEPSGAAPEGGATPTAAPETPAPPTRETCYFLNATILFLFRELRDTALTRRWVTKKIKVEFEELLQTKTAGRLLEGLSLRDVFLGETVPFIKTIRLVRPVVPSATGEPDGPEGEALPAACPEELAFEAEVEYNGGFHLAIDVDLVFGKSAYLFVKLSRVVGRLRLVFTRVPFTHWFFSFVEDPLIDFEVRSQFEGRPMPQLTSIIVNQLKKIIKRKHTLPNYKIRFKPFFPYQTLQGFEEDEEHIHIQQWALTEGRLKVTLLECSRLLIFGSYDREANVHCTLELSSSVWEEKQRSSIKTVELIKGNLQSVGLTLRLVQSTDGYAGHVIIETVAPNSPAAIADLQRGDRLIAIGGVKITSTLQVLKLIKQAGDRVLVYYERPVGQSNQGAVLQDNFGQLEENFLSSSCQSGYEEEAAGLTVDTESRELDSEFEDLASDVRAQNEFKDEAQSLSHSPKRVPTTLSIKPLGAISPVLNRKLAVGSHPLPPKIQSKDGNKPPPLKTSEITDPAQVSKPTQGSAFKPPVPPRPQAKVPLPSADAPNQAEPDVLVEKPEKVVPPPLVDKSAEKQAKNVDAIDDAAAPKQFLAKQEVAKDVTSETSCPTKDSSDDRQTWESSEILYRNKLGKWTRTRASCLFDIEACHRYLNIALWCRDPFKLGGLICLGHVSLKLEDVALGCLATSNTEYLSKLRLEAPSPKAIVTRTALRNLSMQKGFNDKFCYGDITIHFKYLKEGESDHHVVTNVEKEKEPHLVEEVSVLPKEEQFVGQMGLTENKHSFQDTQFQNPTWCDYCKKKVWTKAASQCMFCAYVCHKKCQEKCLAETSVCGATDRRIDRTLKNLRLEGQETLLGLPPRVDAEASKSVNKTTGLTRHIINTSSRLLNLRQVSKTRLSEPGTDLVEPSPKHTPNTSDNEGSDTEVCGPNSPSKRGNSTGIKLVRKEGGLDDSVFIAVKEIGRDLYRGLPTEERIQKLEFMLDKLQNEIDQELEHNNSLVREEKETTDTRKKSLLSAALAKSGERLQALTLLMIHYRAGIEDIETLESLSLDQHSKKISKYTDDTEEDLDNEISQLIDSQPFSSISDDLFGPSESV"},{"id":"SEQ_08319","a":"Q9NUL3","g":"STAU2","d":"Double-stranded RNA-binding protein Staufen homolog 2","L":570,"m":[{"c":"xxψxx[ILN]xxxx(x){0,11}[EK][RS]G(x){0,1}[PM][PA](x){2,32}+xFxx[QR]ψxψG[EN]xxφx[GS][ET]Gx[STN]x[KQ]x(x){0,3}[ANR][AQ][AQ]xxφ[LN]xxLx","u":"61-85","sp":"dispersed","x":"structured_like","cf":"high","why":"Four dispersed globular domain repeats separated by 25-35 aa linkers, anchored by invariant F, two invariant G positions, and a C-terminal L alongside conserved [EK][RS]Gx[PM][PA], +xFxx[QR]ψxψG, and [AQ][AQ]xxφ[LN]xxL blocks (with a 30-aa internal loop insertion in copy 2).","i":[[11,71,"CLVNELARFNRVQPQYKLLNERGPAHSKMFSVQLSLGEQTWESEGSSIKKAQQAVANKALT"],[96,180,"PTVELNGLAMKRGEPAIYRPLDPKPFPNYRANYNFRGMYNQRYHCPVPKIFYVQLTVGNNEFFGEGKTRQAARHNAAMKALQALQ"],[210,273,"SLVFEIALKRNMPVSFEVIKESGPPHMKSFVTRVSVGEFSAEGEGNSKKLSKKRAATTVLQELK"],[310,374,"SRLAQIQQAKKEKEPDYVLLSERGMPRRREFVMQVKVGNEVATGTGPNKKIAKKNAAEAMLLQLG"]]}],"s":"MANPKEKTAMCLVNELARFNRVQPQYKLLNERGPAHSKMFSVQLSLGEQTWESEGSSIKKAQQAVANKALTESTLPKPVQKPPKSNVNNNPGSITPTVELNGLAMKRGEPAIYRPLDPKPFPNYRANYNFRGMYNQRYHCPVPKIFYVQLTVGNNEFFGEGKTRQAARHNAAMKALQALQNEPIPERSPQNGESGKDVDDDKDANKSEISLVFEIALKRNMPVSFEVIKESGPPHMKSFVTRVSVGEFSAEGEGNSKKLSKKRAATTVLQELKKLPPLPVVEKPKLFFKKRPKTIVKAGPEYGQGMNPISRLAQIQQAKKEKEPDYVLLSERGMPRRREFVMQVKVGNEVATGTGPNKKIAKKNAAEAMLLQLGYKASTNLQDQLEKTGENKGWSGPKPGFPEPTNNTPKGILHLSPDVYQEMEASRHKVISGTTLGYLSPKDMNQPSSSFFSISPTSNSSATIARELLMNGTSSTAEAIGLKGSSPTPPCSPVQPSKQLEYLARIQGFQAALSALKQFSEQGLDPIDGAMNIEKGSLEKQAKHLREKADNNQAPPGSIAQDCKKSNSAV"},{"id":"SEQ_08324","a":"Q53FE4","g":"C4orf17","d":"Uncharacterized protein C4orf17","L":359,"m":[{"c":"xPP[TN][VF][KT]","u":6,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Three head-to-tail tandem hexamer repeats in the C-terminal disordered region sharing an in-register PP dipeptide anchor followed by conserved polar ([TN]) and hydrophobic ([VF]) positions, with the first two copies sharing five identical residues (PPTVK).","i":[[245,250,"KPPTVK"],[251,256,"SPPTVK"],[257,262,"LPPNFT"]]}],"s":"MNLNPPTSALQIEGKGSHIMARNVSCFLVRHTPHPRRVCHIKGLNNIPICTVNDDENAFGTLWGVGQSNYLEKNRIPFANCSYPSSTAVQESPVRGMSPAPNGAKVPPRPHSEPSRKIKECFKTSSENPLVIKKEEIKAKRPPSPPKACSTPGSCSSGMTSTKNDVKANTICIPNYLDQEIKILAKLCSILHTDSLAEVLQWLLHATSKEKEWVSALIHSELAEINLLTHHRRNTSMEPAAETGKPPTVKSPPTVKLPPNFTAKSKVLTRDTEGDQPTRVSSQGSEENKEVPKEAEHKPPLLIRRNNMKIPVAEYFSKPNSPPRPNTQESGSAKPVSARSIQEYNLCPQRACYPSTHRR"},{"id":"SEQ_08326","a":"P78524","g":"DENND2B","d":"DENN domain-containing protein 2B","L":1137,"m":[{"c":"+[ST]F-[FY]","u":5,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed pentapeptide motifs within the N-terminal/central aromatic-depleted disordered region with strict conservation across all five positions: basic (+), hydroxyl ([ST]), invariant F, acidic (-), and aromatic ([FY]).","i":[[218,222,"KTFDF"],[392,396,"RTFEY"],[448,452,"KSFEF"]]}],"s":"MTMTANKNSSITHGAGGTKAPRGTLSRSQSVSPPPVLSPPRSPIYPLSDSETSACRYPSHSSSRVLLKDRHPPAPSPQNPQDPSPDTSPPTCPFKTASFGYLDRSPSACKRDAQKESVQGAAQDVAGVAACLPLAQSTPFPGPAAGPRGVLLTRTGTRAHSLGIREKISAWEGRREASPRMSMCGEKREGSGSEWAASEGCPSLGCPSVVPSPCSSEKTFDFKGLRRMSRTFSECSYPETEEEGEALPVRDSFYRLEKRLGRSEPSAFLRGHGSRKESSAVLSRIQKIEQVLKEQPGRGLPQLPSSCYSVDRGKRKTGTLGSLEEPAGGASVSAGSRAVGVAGVAGEAGPPPEREGSGSTKPGTPGNSPSSQRLPSKSSLDPAVNPVPKPKRTFEYEADKNPKSKPSNGLPPSPTPAAPPPLPSTPAPPVTRRPKKDMRGHRKSQSRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSKSTLEENAYEDIVGDLPKENPYEDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSPPTQLSLKPNSQSLRSGNWSERKSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLSTTSELLSSRRARRIPKLVQRINSIYNAKRGKKRLKKLSMSSIETASLRDENSESESDSDDRFKAHTQRLVHIQSMLKRAPSYRTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSYQFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN"},{"id":"SEQ_08330","a":"Q9BYJ9","g":"YTHDF1","d":"YTH domain-containing family protein 1","L":559,"m":[{"c":"APxPQ[QA]","u":6,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Three contiguous head-to-tail hexapeptide repeats in the central proline/glutamine-rich disordered region sharing four strictly invariant positions (A1, P2, P4, Q5) and a constrained [QA]6 C-terminal position.","i":[[283,288,"APVPQQ"],[289,294,"APSPQA"],[295,300,"APQPQQ"]]},{"c":"PYL[ST][GST]","u":5,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed pentapeptide motifs clustered within the polar N-terminal disordered region (residues 36-88, alongside a closely related PYSLN variant) anchored by an invariant PYL core followed by two small/hydroxyl positions.","i":[[36,40,"PYLTG"],[54,58,"PYLSS"],[84,88,"PYLTT"]]}],"s":"MSATSVDTQRTKGQDNKVQNGSLHQKDTVHDNDFEPYLTGQSNQSNSYPSMSDPYLSSYYPPSIGFPYSLNEAPWSTAGDPPIPYLTTYGQLSNGDHHFMHDAVFGQPGGLGNNIYQHRFNFFPENPAFSAWGTSGSQGQQTQSSAYGSSYTYPPSSLGGTVVDGQPGFHSDTLSKAPGMNSLEQGMVGLKIGDVSSSAVKTVGSVVSSVALTGVLSGNGGTNVNMPVSKPTSWAAIASKPAKPQPKMKTKSGPVMGGGLPPPPIKHNMDIGTWDNKGPVPKAPVPQQAPSPQAAPQPQQVAQPLPAQPPALAQPQYQSPQQPPQTRWVAPRNRNAAFGQSGGAGSDSNSPGNVQPNSAPSVESHPVLEKLKAAHSYNPKEFEWNLKSGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDSAFRCMSSKGPVYLLFSVNGSGHFCGVAEMKSPVDYGTSAGVWSQDKWKGKFDVQWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIISSYKHTTSIFDDFAHYEKRQEEEEVVRKERQSRNKQ"},{"id":"SEQ_08332","a":"Q96IW2","g":"SHD","d":"SH2 domain-containing adapter protein D","L":340,"m":[{"c":"[FY]xxPΩ-","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five dispersed hexapeptide motifs across the N-terminal disordered region anchored by an N-terminal [FY] aromatic, a fixed proline at position 4, a second aromatic (Y/F/W) at position 5, and an invariant acidic residue (D/E) at position 6.","i":[[42,47,"FEDPYE"],[106,111,"YLDPFD"],[123,128,"YMEPYD"],[144,149,"YDTPYE"],[181,186,"YDQPWE"]]}],"s":"MAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYRAQKNLDFEDPYEDAESRLEPDPAGPGDSKNPGDAKYGSPKHRLIKVEAADMARAKALLGGPGEELEADTEYLDPFDAQPHPAPPDDGYMEPYDAQWVMSELPGRGVQLYDTPYEEQDPETADGPPSGQKPRQSRMPQEDERPADEYDQPWEWKKDHISRAFAVQFDSPEWERTPGSAKELRRPPPRSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP"},{"id":"SEQ_08333","a":"Q00653","g":"NFKB2","d":"Nuclear factor NF-kappa-B p100 subunit","L":900,"m":[{"c":"[GH]x[TSY][PA]ψ[HD]L[AT](x){7,13}[LI][VL](x){12,18}","u":"33-40","sp":"tandem","x":"structured_like","cf":"high","why":"Seven 33-40 aa structured repeats (six contiguous head-to-tail copies from residues 488-700 plus a seventh copy after a 29-aa polar linker) defined by a highly conserved N-terminal GxTPψHLA signature and a central [LI][VL] hydrophobic pair.","i":[[488,526,"GDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHL"],[527,559,"HQTPLHLAVITGQTSVVSFLLRVGADPALLDRH"],[560,599,"GDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFE"],[600,633,"GLYPVHLAVRARSPECLDLLVDSGAEVEATERQG"],[634,667,"GRTALHLATEMEELGLVTHLVTKLRANVNARTFA"],[668,700,"GNTPLHLAAGLGYPTLTRLLLKAGADIHAENEE"],[730,762,"GHTPLDLTCSTKVKTLLLNAAQNTMEPPLTPPS"]]}],"s":"MESCYNPGLDGIIEYDDFKLNSSIVEPKEPAPETADGPYLVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGICAVSVGPKDMTAQFNNLGVLHVTKKNMMGTMIQKLQRQRLRSRPQGLTEAEQRELEQEAKELKKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQKDDIEVRFYEDDENGWQAFGDFSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPLVEDKEEVQRKRRKALPTFSQPFGGGSHMGGGSGGAAGGYGGAGGGGSLGFFPSSLAYSPYQSGAGPMGCYPGGGGGAQMAATVPSRDSGEEAAEPSAPSRTPQCEPQAPEMLQRAREYNARLFGLAQRSARALLDYGVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKDTRSSFRGHTPLDLTCSTKVKTLLLNAAQNTMEPPLTPPSPAGPGLSLGDTALQNLEQLLDGPEAQGSWAELAERLGLRSLVDTYRQTTSPSGSLLRSYELAGGDLAGLLEALSDMGLEEGVRLLRGPETRDKLPSTAEVKEDSAYGSQSVEQEAEKLGPPPEPPGGLCHGHPQPQVH"},{"id":"SEQ_08336","a":"Q86TB3","g":"ALPK2","d":"Alpha-protein kinase 2","L":2170,"m":[{"c":"P+[IL]LESSVDP[IV]DExx[LV]","u":16,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Highly conserved 16-residue internal duplication in the central disordered region, anchored by 10 identical residues (P..LESSVDP.DE) and 4 conservative basic/aliphatic positions (+, [IL], [IV], [LV]) separated by a 44-residue linker.","i":[[1336,1351,"PRLLESSVDPVDEKEL"],[1396,1411,"PKILESSVDPIDEISV"]]}],"s":"MKDSEGPQRPPLCFLSTLLSQKVPEKSDAVLRCIISGQPKPEVTWYKNGQAIDGSGIISNYEFFENQYIHVLHLSCCTKNDAAVYQISAKNSFGMICCSASVEVECSSENPQLSPNLEDDRDRGWKHETGTHEEERANQIDEKEHPYKEEESISPGTPRSADSSPSKSNHSLSLQSLGNLDISVSSSENPLGVKGTRHTGEAYDPSNTEEIANGLLFLNSSHIYEKQDRCCHKTVHSMASKFTDGDLNNDGPHDEGLRSSQQNPKVQKYISFSLPLSEATAHIYPGDSAVANKQPSPQLSSEDSDSDYELCPEITLTYTEEFSDDDLEYLECSDVMTDYSNAVWQRNLLGTEHVFLLESDDEEMEFGEHCLGGCEHFLSGMGCGSRVSGDAGPMVATAGFCGHHSQPQEVGVRSSRVSKHGPSSPQTGMTLILGPHQDGTSSVTEQGRYKLPTAPEAAENDYPGIQGETRDSHQAREEFASDNLLNMDESVRETEMKLLSGESENSGMSQCWETAADKRVGGKDLWSKRGSRKSARVRQPGMKGNPKKPNANLRESTTEGTLHLCSAKESAEPPLTQSDKRETSHTTAAATGRSSHADARECAISTQAEQEAKTLQTSTDSVSKEGNTNCKGEGMQVNTLFETSQVPDWSDPPQVQVQETVRETISCSQMPAFSEPAGEESPFTGTTTISFSNLGGVHKENASLAQHSEVKPCTCGPQHEEKQDRDGNIPDNFREDLKYEQSISEANDETMSPGVFSRHLPKDARADFREPVAVSVASPEPTDTALTLENVCDEPRDREAVCAMECFEAGDQGTCFDTIDSLVGRPVDKYSPQEICSVDTELAEGQNKVSDLCSSNDKTLEVFFQTQVSETSVSTCKSSKDGNSVMSPLFTSTFTLNISHTASEGATGENLAKVENSTYPLASTVHAGQEQPSPSNSGGLDETQLLSSENNPLVQFKEGGDKSPSPSAADTTATPASYSSIVSFPWEKPTTLTANNECFQATRETEDTSTVTIATEVHPAKYLAVSIPEDKHAGGTEERFPRASHEKVSQFPSQVQLDHILSGATIKSTKELLCRAPSVPGVPHHVLQLPEGEGFCSNSPLQVDNLSGDKSQTVDRADFRSYEENFQERGSETKQGVQQQSLSQQGSLSAPDFQQSLPTTSAAQEERNLVPTAHSPASSREGAGQRSGWGTRVSVVAETAGEEDSQALSNVPSLSDILLEESKEYRPGNWEAGNKLKIITLEASASEIWPPRQLTNSESKASDGGLIIPDKVWAVPDSLKADAVVPELAPSEIAALAHSPEDAESALADSRESHKGEEPTISVHWRSLSSRGFSQPRLLESSVDPVDEKELSVTDSLSAASETGGKENVNNVSQDQEEKQLKMDHTAFFKKFLTCPKILESSVDPIDEISVIEYTRAGKPEPSETTPQGAREGGQSNDGNMGHEAEIQPAILQVPCLQGTILSENRISRSQEGSMKQEAEQIQPEEAKTAIWQVLQPSEGGERIPSGCSIGQIQESSDGSLGEAEQSKKDKAELISPTSPLSSCLPIMTHASLGVDTHNSTGQIHDVPENDIVEPRKRQYVFPVSQKRGTIENERGKPLPSSPDLTRFPCTSSPEGNVTDFLISHKMEEPKIEVLQIGETKPPSSSSSSAKTLAFISGERELEKAPKLLQDPCQKGTLGCAKKSREREKSLEARAGKSPGTLTAVTGSEEVKRKPEAPGSGHLAEGVKKKILSRVAALRLKLEEKENIRKNSAFLKKMPKLETSLSHTEEKQDPKKPSCKREGRAPVLLKKIQAEMFPEHSGNVKLSCQFAEIHEDSTICWTKDSKSIAQVQRSAGDNSTVSFAIVQASPKDQGLYYCCIKNSYGKVTAEFNLTAEVLKQLSSRQDTKGCEEIEFSQLIFKEDFLHDSYFGGRLRGQIATEELHFGEGVHRKAFRSTVMHGLMPVFKPGHACVLKVHNAIAYGTRNNDELIQRNYKLAAQECYVQNTARYYAKIYAAEAQPLEGFGEVPEIIPIFLIHRPENNIPYATVEEELIGEFVKYSIRDGKEINFLRRESEAGQKCCTFQHWVYQKTSGCLLVTDMQGVGMKLTDVGIATLAKGYKGFKGNCSMTFIDQFKALHQCNKYCKMLGLKSLQNNNQKQKQPSIGKSKVQTNSMTIKKAGPETPGEKKT"},{"id":"SEQ_08356","a":"Q9C0J8","g":"WDR33","d":"pre-mRNA 3' end processing protein WDR33","L":1336,"m":[{"c":"xxxxxxxxφxxφxφx(x){3,4}xφφxxx(x){4,6}xxφ[WF]x","u":"34-36","sp":"periodic","x":"structured_like","cf":"high","why":"Seven periodic 34-36 aa beta-propeller-like structured repeats separated by regular 7-9 aa linkers, anchored by conserved hydrophobic beta-strand positions, an N-terminal [AG]H dyad in copies 2-7, and a C-terminal φ[WF]x motif.","i":[[114,147,"STNKVKCPVFVVRWTPEGRRLVTGASSGEFTLWN"],[156,189,"ILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQ"],[197,230,"MFQAHKEAIREASFSPTDNKFATCSDDGTVRIWD"],[239,274,"ILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWD"],[283,316,"TLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFD"],[326,360,"VFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWH"],[370,403,"MEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFWT"]]},{"c":"PQEψRG","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Four non-overlapping occurrences of a 6-residue motif in the central Pro/Gly/Gln-rich disordered region with five invariant anchor positions (P, Q, E, R, G) flanking a conserved large aliphatic residue (M/I/L).","i":[[807,812,"PQEMRG"],[824,829,"PQEMRG"],[830,835,"PQEIRG"],[849,854,"PQELRG"]]}],"s":"MATEIGSPPRFFHMPRFQHQAPRQLFYKRPDFAQQQAMQQLTFDGKRMRKAVNRKTIDYNPSVIKYLENRIWQRDQRDMRAIQPDAGYYNDLVPPIGMLNNPMNAVTTKFVRTSTNKVKCPVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFWTRNRPGDKMRDRYNLNLLPGMSEDGVEYDDLEPNSLAVIPGMGIPEQLKLAMEQEQMGKDESNEIEMTIPGLDWGMEEVMQKDQKKVPQKKVPYAKPIPAQFQQAWMQNKVPIPAPNEVLNDRKEDIKLEEKKKTQAEIEQEMATLQYTNPQLLEQLKIERLAQKQVEQIQPPPSSGTPLLGPQPFPGQGPMSQIPQGFQQPHPSQQMPMNMAQMGPPGPQGQFRPPGPQGQMGPQGPPLHQGGGGPQGFMGPQGPQGPPQGLPRPQDMHGPQGMQRHPGPHGPLGPQGPPGPQGSSGPQGHMGPQGPPGPQGHIGPQGPPGPQGHLGPQGPPGTQGMQGPPGPRGMQGPPHPHGIQGGPGSQGIQGPVSQGPLMGLNPRGMQGPPGPRENQGPAPQGMIMGHPPQEMRGPHPPGGLLGHGPQEMRGPQEIRGMQGPPPQGSMLGPPQELRGPPGSQSQQGPPQGSLGPPPQGGMQGPPGPQGQQNPARGPHPSQGPIPFQQQKTPLLGDGPRAPFNQEGQSTGPPPLIPGLGQQGAQGRIPPLNPGQGPGPNKGDSRGPPNHHMGPMSERRHEQSGGPEHGPERGPFRGGQDCRGPPDRRGPHPDFPDDFSRPDDFHPDKRFGHRLREFEGRGGPLPQEEKWRRGGPGPPFPPDHREFSEGDGRGAARGPPGAWEGRRPGDERFPRDPEDPRFRGRREESFRRGAPPRHEGRAPPRGRDGFPGPEDFGPEENFDASEEAARGRDLRGRGRGTPRGGRKGLLPTPDEFPRFEGGRKPDSWDGNREPGPGHEHFRDTPRPDHPPHDGHSPASRERSSSLQGMDMASLPPRKRPWHDGPGTSEHREMEAPGGPSEDRGGKGRGGPGPAQRVPKSGRSSSLDGEHHDGYHRDEPFGGPPGSGTPSRGGRSGSNWGRGSNMNSGPPRRGASRGGGRGR"},{"id":"SEQ_08368","a":"Q8TD26","g":"CHD6","d":"ATP-dependent chromatin remodeler CHD6","L":2715,"m":[{"c":"ψPV(x){0,1}WW-(x){4,5}+[DS]LLIGxφKHGφxRx[DN]xφ(x){2,3}DPxL[CS]FL-xφ","u":"41-42","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of a 41-42 aa structured domain separated by ~258 residues, sharing 17 identical anchor positions (PV, WW, LLIG, KHG, R, DP, L, FL) and conserved hydrophobic and charged positions across three short variable loops.","i":[[1272,1312,"IPVDWWDAEADKSLLIGVFKHGYERYNAMRADPALCFLEKV"],[1571,1612,"LPVWWECGKHDRDLLIGTAKHGLNRTDCYIMNDPQLSFLDAY"]]},{"c":"GMDL[ISV][FG][IL]","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 7-aa motifs within the P/S/G-enriched C-terminal disordered region sharing an invariant GMDL tetrapeptide core followed by a constrained hydrophobic C-terminal tail ([ISV][FG][IL]), with a degenerate AMDLS variant nearby.","i":[[2253,2259,"GMDLSGI"],[2297,2303,"GMDLIFL"],[2475,2481,"GMDLVGL"]]}],"s":"MKMKIQKKEKQLSNLKVLNHSPMSDASVNFDYKSPSPFDCSTDQEEKIEDVASHCLPQKDLYTAEEEAATLFPRKMTSHNGMEDSGGGGTGVKKKRKKKEPGDQEGAAKGSKDREPKPKRKREPKEPKEPRKAKEPKKAKEHKEPKQKDGAKKARKPREASGTKEAKEKRSCTDSAARTKSRKASKEQGPTPVEKKKKGKRKSETTVESLELDQGLTNPSLRSPEESTESTDSQKRRSGRQVKRRKYNEDLDFKVVDDDGETIAVLGAGRTSALSASTLAWQAEEPPEDDANIIEKILASKTVQEVHPGEPPFDLELFYVKYRNFSYLHCKWATMEELEKDPRIAQKIKRFRNKQAQMKHIFTEPDEDLFNPDYVEVDRILEVAHTKDAETGEEVTHYLVKWCSLPYEESTWELEEDVDPAKVKEFESLQVLPEIKHVERPASDSWQKLEKSREYKNSNQLREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIFLRGIHGPFLIIAPLSTITNWEREFRTWTEMNAIVYHGSQISRQMIQQYEMVYRDAQGNPLSGVFKFHVVITTFEMILADCPELKKIHWSCVIIDEAHRLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETAFLEEFGDLKTEEQVKKLQSILKPMMLRRLKDDVEKNLAPKQETIIEVELTNIQKKYYRAILEKNFSFLTKGANQHNMPNLINTMMELRKCCNHPYLINGAEEKILEDFRKTHSPDAPDFQLQAMIQAAGKLVLIDKLLPKLIAGGHKVLIFSQMVRCLDILEDYLIQRRYTYERIDGRVRGNLRQAAIDRFCKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKLGLDKAVLQDINRKGGTNGVQQLSKMEVEDLLRKGAYGALMDEEDEGSKFCEEDIDQILQRRTHTITIQSEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKIAELDTEAKNEKESLVIDRPRVRKQTKHYNSFEEDELMEFSELDSDSDERPTRSRRLNDKARRYLRAECFRVEKNLLIFGWGRWKDILTHGRFKWHLNEKDMEMICRALLVYCVKHYKGDEKIKSFIWELITPTKDGQAQTLQNHSGLSAPVPRGRKGKKTKNQLLIPELKDADWLATCNPEVVLHDDGYKKHLKQHCNKVLLRVRMLYYLKAEILGEAAEKAFEGSPARELDVPLPDIDYMEIPVDWWDAEADKSLLIGVFKHGYERYNAMRADPALCFLEKVGMPDEKSLSAEQGVTDGTSDIPERGNTDKEDNAEDKVDGLQKQTESSSDGGDGVFSEKKDDSRAAQDGSDPDKSPWPVSSALTARLRRLVTVYQRCNRKELCRPEILGPGNQGYWVQEEMFRRTSEMDLINKEAQKRWTRREQADFYRTVSSFGVVYDQEKKTFDWTQFRIISRLDKKSDESLEQYFYSFVAMCRNVCRLPTWKDGGPPDTTIYVEPITEERAARTLYRIELLRKVREQVLKCPQLHERLQLCRPSLYLPVWWECGKHDRDLLIGTAKHGLNRTDCYIMNDPQLSFLDAYRNYAQHKRSGTQAPGNLCCLYQTNSKLYESLTYSQMSRTSESLENEPENLVRVESRDDHLSLPDVTCENFISKVQDVISINHDESLLPESLESMMYGKKVLSQEPSSFQESPSTNTESRKDVITISISKDGNCQSGGPEAEIASGPTFMGSLEAGGVAQANIKNGKHLLMSISKEGELCCSEAGQRPENIGQLEAKCLASPSLNPGNESGFVDMCSLSVCDSKRNLSSDQQLIDLLENKSLESKLILSQNHSDEEEEEEENEEENLAMAVGMGERPEVLHLTEPTTNISREKNQGFQDETKKGSLEVANQTPGLQRAFPAPAACQCHCKHMERWMHGLENDEFEIEKPKAYIPDLFKSKTNTIAMEGEPTAIPSQPFKVKHELLKEPWKESAEGQNVFPTYPLEGSELKSEDMDFENKDDYDRDGNCHSQDYPGKYSEEESKSSTSGITGDIGDELQEARAPTIAQLLQEKTLYSFSEWPKDRVIINRLDNICHVVLKGKWPSSQQYEPSGTLPTPVLTSSAGSRTSLSEPEAAEHSFSNGAALAAQIHKESFLAPVFTKDEQKHRRPYEFEVERDAKARGLEQFSATHGHTPIILNGWHGESAMDLSCSSEGSPGATSPFPVSASTPKIGAISSLQGALGMDLSGILQAGLIHPVTGQIVNGSLRRDDAATRRRRGRRKHVEGGMDLIFLKEQTLQAGILEVHEDPGQATLSTTHPEGPGPATSAPEPATAASSQAEKSIPSKSLLDWLRQQADYSLEVPGFGANFSDKPKQRRPRCKEPGKLDVSSLSGEERVPAIPKEPGLRGFLPENKFNHTLAEPILRDTGPRRRGRRPRSELLKAPSIVADSPSGMGPLFMNGLIAGMDLVGLQNMRNMPGIPLTGLVGFPAGFATMPTGEEVKSTLSMLPMMLPGMAAVPQMFGVGGLLSPPMATTCTSTAPASLSSTTKSGTAVTEKTAEDKPSSHDVKTDTLAEDKPGPGPFSDQSEPAITTSSPVAFNPFLIPGVSPGLIYPSMFLSPGMGMALPAMQQARHSEIVGLESQKRKKKKTKGDNPNSHPEPAPSCEREPSGDENCAEPSAPLPAEREHGAQAGEGALKDSNNDTN"},{"id":"SEQ_08386","a":"Q7Z572","g":"SPATA21","d":"Spermatogenesis-associated protein 21","L":469,"m":[{"c":"[AT][PS]VP[AT]SxP","u":8,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 8-residue copies in the central proline/serine-rich disordered region share invariant V3, P4, S6, and P8 anchors alongside constrained [AT]1, [PS]2, and [AT]5 positions, with the first and third copies sharing a PVPTSxP core.","i":[[118,125,"TPVPTSAP"],[132,139,"ASVPASGP"],[156,163,"APVPTSMP"]]}],"s":"MDNRNTQMYTEEEKTVNPFLPSTPGPKKAKGGGEAVETHPAPGPLPPPEVRDIGERREPDRAQQQPQKPAVAAGTQSLGNFRQGFMKCLLEVEKMEASHRRASKARSQTAQKSPRTLTPVPTSAPSLPQTPASVPASGPSWARLPAPGPEPAPMGAPVPTSMPCPVLLGPALDLGWRRMELLHQSSERTLSYAKARQEPEEQSLQKLYQNREKSEEQLTLKQEEAFRSYFEIFNGPGEVDAQSLKNILLLMGFSVTLAQVEDALMSADVNGDGRVDFKDFLAVMTDTRRFFCSVEQNALSDMAPHNPHTLLFEILSLLVEMLALPEAVLEEITNYYQKKLKEGTCKAQEMEAAVGRLRLQKLPYNPQQEESSEVPERKVLSILSRLKQQNYAPNLQSPYAQVPCILLCPQLDKKMVRRQPSNHYALDQCTPPGLDPDIRSPFFQSGSQGNREHNSDSRKWLSSVPARTH"},{"id":"SEQ_08387","a":"P0DJD0","g":"RGPD1","d":"RANBP2-like and GRIP domain-containing protein 1","L":1748,"m":[{"c":"[HY]FEPVVxψP-xVEψx[ST]GEExExVψΩSxxφxLΩRΩDx-ψxQWKERGψG[DN]ψKILxNxxNxxxRψψMRRDQVLKψCANHxITxxMoLxxψxG[ST]-RφWψWxAxDFxDG-xKψE[HR]LAφxFKxx-ψA-xFKxxF-E","u":130,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two-copy 130-aa internal domain duplication in the C-terminal half separated by a 167-aa disordered linker, sharing >50% ungapped sequence identity with invariant blocks such as FEPVV, WKERGψG[DN]ψKIL, MRRDQVLKψCANH, and WψWxAxDFxDG.","i":[[1021,1150,"HFEPVVQMPEKVELVTGEEGEKVLYSQGVKLFRFDAEISQWKERGLGNLKILKNEVNGKPRMLMRRDQVLKVCANHWITTTMNLKPLSGSDRAWMWLASDFSDGDAKLERLAAQFKTPELAEEFKQKFEE"],[1318,1447,"YFEPVVPLPDLVEVSSGEENEQVVFSHRAELYRYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMSLQNMKGTERVWVWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDE"]]},{"c":"xFxF[GS]x","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Six dispersed FxFG/FxFSF-type short motifs distributed across all three Ser/Thr/Gly/Pro-enriched disordered regions flanking the duplicated domains, anchored by a conserved FxF aromatic dyad followed by G or S (with a third F whenever S occupies position 5).","i":[[906,911,"GFKFGI"],[967,972,"GFQFGK"],[1275,1280,"GFNFSF"],[1522,1527,"KFVFGS"],[1541,1546,"PFAFGN"],[1553,1558,"LFGFSF"]]}],"s":"MNVMGFNTDRLAWTRNKLRGFYFAKLYYEAKEYDLAKKYVCTYLSVQERDPRAHRFLGLLYELEENTEKAVECYRRSLELNPPQKDLVLKIAELLCKNDVTDGRAKYWVERAAKLFPGSPAIYKLKEHLLDCEGEDGWNKLFDWIQSELYVRPDDVHMNIRLVELYRSNKRLKDAVARCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYANLMLLTLSTRDVQESRELLESFDSALQSAKSSLGGNDELSATFLEMKGHFYMHAGSLLLKMGQHGNNVQWQALSELAALCYVIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLNLSRGKQDFLKEVVETFANKSGQSVLYNALFSSQSSKDTSFLGSDDIGNIDVQEPELEDLARYDVGAIQAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPQETSRLETNAPESICILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKRLCTERQKSWWDAVCTLIHRKAVPGNSAELRLVVQHEINTLRAQEKHGLQPALLVHWAKCLQKMGRGLNSSYDQQEYIGRSVHYWKKVLPLLKIIKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAVHGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDAVFPEEQEECKNYLRKTRDYLIKIIDDSDSNLSVVKKLPVPLESVKEMLKSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTPSPTKYSLSPSKSYKYSPKTPPRWAEDQNSLRKMICQEVKAITKLNSSKSASRHRWPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKGSSNTEFKSTKEGFSIAVSADGFKFGISEPGNQEKKSEKPLENDTGFQAQDISGQKNGRGVIFGQTSSTFTFADVAKSTSGEGFQFGKKDPNFKGFSGAGEKLFSSQCGKMANKANTSGDFEKDDDACKTEDSDDIHFEPVVQMPEKVELVTGEEGEKVLYSQGVKLFRFDAEISQWKERGLGNLKILKNEVNGKPRMLMRRDQVLKVCANHWITTTMNLKPLSGSDRAWMWLASDFSDGDAKLERLAAQFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGPTLEWDNYDLREDALDDNVSSSSVHDSPLASSPVRKNIFRFDESTTGFNFSFKSALSLSKSPAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAELYRYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMSLQNMKGTERVWVWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPRESPCGKIAVAVLEETTRERTDVIQGDDVADAASEVEVSSTSETTTKAVVSPPKFVFGSESVKRIFSSEKSNPFAFGNSSATGSLFGFSFNAPLKSNDSETSSVAQSGSESKVEPKKCELSKNSDIEQSSDSKVKNLSASFPMEESSINYTFKTPEKEPPLWHAEFTKEELVQKLSSTTKSADQLNGLLRETEATSAVLMEQIKLLKSEIRRLERNQEESAANVEHLKNVLLQFIFLKPGSERESLLPVINTMLQLSPEEKGKLAAVAQGLQETSIPKKK"},{"id":"SEQ_08400","a":"P0DX01","g":"GOLGA6L25","d":"Golgin subfamily A member 6-like protein 25","L":826,"m":[{"c":"QEEKψx[ER]","u":7,"sp":"tandem","x":"mixed","cf":"high","why":"Extensive C-terminal tandem array of 66 conserved 7-aa units (positions 278-825, punctuated only by occasional 6-aa single-residue deletions) anchored by fixed QEE, K, and aliphatic I/M/V at position 5, further organized into four ~90%-identical 56-aa higher-order duplications at the C-terminus.","i":[[278,284,"QEEKMWR"],[285,291,"QEEKIQE"],[292,298,"REEKIQE"],[299,305,"QEEKIRE"],[306,312,"QEEKMRR"],[313,319,"QEEMMWE"],[320,326,"KEEKMRR"],[327,333,"QEEMMWE"],[334,340,"KEEKIRE"],[341,347,"LEEKMHE"],[354,360,"QEEKRQE"],[373,379,"QEAKMWR"],[380,386,"QEEKIRE"],[387,393,"QEEKIRE"],[394,400,"QEKKMWR"],[401,407,"QEEKIHE"],[426,432,"QEEKIRE"],[439,445,"QKEKMHE"],[446,452,"QEEKIRK"],[453,459,"QEEKVWR"],[460,466,"QEEKMHD"],[467,473,"QEEKIRE"],[474,480,"QEEKVWR"],[481,487,"QEEKIRE"],[488,494,"QEEKMWR"],[495,501,"QEEKIRE"],[508,514,"EEEKMHE"],[527,533,"QEDKMWR"],[534,540,"QEEKIRE"],[541,547,"QEEKVWR"],[548,554,"QEEKIRE"],[555,561,"QEEKRQE"],[562,568,"QEEKMWK"],[569,575,"QEEKIRE"],[576,582,"QEEKIRE"],[589,595,"QEEKIRE"],[596,602,"QEEMMQE"],[603,609,"QEEKMGE"],[610,616,"QEEKMQE"],[623,629,"QEEKIRE"],[630,636,"QEEKIRE"],[637,643,"QKEKIRE"],[644,650,"QEEKIWE"],[651,657,"QEEKIRE"],[658,664,"QEEMMQE"],[665,671,"QEEKMGE"],[672,678,"QEEKMWE"],[679,685,"QEEEMQE"],[686,692,"QEEKMRR"],[693,699,"QEEKIRE"],[700,706,"QEKKIRE"],[707,713,"QEEKIRE"],[714,720,"QEEMMQE"],[721,727,"QEEKMGE"],[728,734,"QEGKMCE"],[735,741,"QEAKMQE"],[742,748,"QEEKMRR"],[749,755,"QEEKIRE"],[756,762,"QEKKIRE"],[763,769,"QEEKIRE"],[770,776,"QEEMMQE"],[777,783,"QEEKMWE"],[784,790,"QEEKMCE"],[791,797,"QEEKMQE"],[798,804,"QEEKMRR"],[805,811,"QEEKMRE"],[819,825,"QEEKMQE"]]},{"c":"PHLPTH","u":6,"sp":"tandem","x":"disordered_like","cf":"high","why":"Four 100%-identical head-to-tail tandem copies of the 6-residue PHLPTH motif in the N-terminal disordered tail (positions 5-28).","i":[[5,10,"PHLPTH"],[11,16,"PHLPTH"],[17,22,"PHLPTH"],[23,28,"PHLPTH"]]}],"s":"MWPQPHLPTHPHLPTHPHLPTHPHLPTHPMMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIREQEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQEH"},{"id":"SEQ_08403","a":"Q9UKV0","g":"HDAC9","d":"Histone deacetylase 9","L":1011,"m":[{"c":"[PL]ψx+TxSxP","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 9-aa motifs in the central Ser/Pro-rich disordered region share invariant T, S, and C-terminal P anchors, a conserved basic residue (+), and an N-terminal [PL]ψ hydrophobic pair.","i":[[214,222,"PLRKTASEP"],[445,453,"PLNRTQSAP"],[605,613,"LVSRTHSSP"]]}],"s":"MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSMSLKFS"},{"id":"SEQ_08407","a":"O95104","g":"SCAF4","d":"SR-related and CTD-associated factor 4","L":1147,"m":[{"c":"ΩG[NR]Rx","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four 5-aa repeats clustered in the C-terminal polar/charged disordered region (one tandem pair and two dispersed copies) feature an N-terminal aromatic anchor (F/Y/W), invariant G and R positions, and a constrained [NR] choice.","i":[[1000,1004,"FGRRS"],[1005,1009,"FGNRV"],[1016,1020,"YGNRN"],[1033,1037,"WGRRS"]]},{"c":"[LP][PR]PGFxP","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three closely spaced 7-aa motifs in the central proline-rich disordered region are anchored by an invariant PGF triad and C-terminal P, flanked N-terminally by constrained [LP][PR] positions.","i":[[707,713,"PPPGFGP"],[725,731,"LRPGFNP"],[734,740,"LPPGFLP"]]},{"c":"[MP][MP]PPHx[MQ][KRH]","u":8,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three 8-aa repeats separated by 7-11 aa linkers in the Met/Pro/Gly-rich disordered region pair an N-terminal [MP][MP] dipeptide with an invariant PPH core and C-terminal [MQ][KRH] positions.","i":[[865,872,"MPPPHLQR"],[880,887,"PMPPHMMH"],[899,906,"MPPPHGMK"]]}],"s":"MDAVNAFNQELFSLMDMKPPISRAKMILITKAAIKAIKLYKHVVQIVEKFIKKCKPEYKVPGLYVIDSIVRQSRHQFGTDKDVFGPRFSKNITATFQYLYLCPSEDKSKIVRVLNLWQKNGVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQPCIQEVKRHMSDNRKSRSRSASRSPKRRRSRSGSRSRRSRHRRSRSRSRDRRRHSPRSRSQERRDREKERERRQKGLPQVKPETASVCSTTLWVGQLDKRTTQQDVASLLEEFGPIESINMIPPRGCAYIVMVHRQDAYRALQKLSRGNYKVNQKSIKIAWALNKGIKADYKQYWDVELGVTYIPWDKVKPEELESFCEGGMLDSDTLNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNSTIAGINEDTTKDLSIGNPIPTVVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPPPSQQPPPTQQQPQQFRNDNRQQFNSGRDQERFGRRSFGNRVENDRERYGNRNDDRDNSNRDRREWGRRSPDRDRHRDLEERNRRSSGHRDRERDSRDRESRREKEEARGKEKPEVTDRAGGNKTVEPPISQVGNVDTASELEKGVSEAAVLKPSEELPAEATSSVEPEKDSGSAAEAPR"},{"id":"SEQ_08419","a":"Q9UHJ3","g":"SFMBT1","d":"Scm-like with four MBT domains protein 1","L":866,"m":[{"c":"[SDE]Wx-φL(x){25,31}[MS][KR]LExxxxxxxxxxx[VIP][AV]Tψxxxxxxx[LY]xLxxx[GD](x){16,20}[LI][FYH][PH]ψ[GQ]W[CAS]xx[NQ][GK]xx[LI]x[PAT]P","u":"97-106","sp":"periodic","x":"structured_like","cf":"high","why":"Four periodic 97-106 aa globular domain repeats separated by regular 8-10 aa linkers across residues 21-453, anchored by an N-terminal [SDE]Wx-φL motif and a conserved ~67 aa core ([MS][KR]LE...[VIP][AV]Tψ...[LY]xL...ψ[GQ]W...P).","i":[[21,120,"SWEDYLEETGSTAVPYGSFKHVDTRLQNGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYGEDRRADFWCDIRKADLYPIGWCEQNKKTLEAP"],[129,232,"DWDEFLRQTLIGACSPPVPLLEGLRNGRNPLDLIAPGSRLECQAFQDSLSTWIVTVVENIGGRLKLRYEGLESSDNYEHWLYYLDPFLHHVGWAAQQGYELQPP"],[243,348,"EWQEILAKVKEEEEEPLPSYLFKDKQVIGIHTFSVNMKLEAVDPWSPFGISPATVVKVFDEKYFLVEMDDLRPENHARRSFVCHADSPGIFPVQWSLKNGLHISPP"],[357,453,"DWADYLKQCGAEAAPQRCFPPLISEHEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPIPECIVSVESMDIFPLGWCETNGHPLSTP"]]}],"s":"MNGEQQLDADAGSGMEEVELSWEDYLEETGSTAVPYGSFKHVDTRLQNGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYGEDRRADFWCDIRKADLYPIGWCEQNKKTLEAPEGIRDKVSDWDEFLRQTLIGACSPPVPLLEGLRNGRNPLDLIAPGSRLECQAFQDSLSTWIVTVVENIGGRLKLRYEGLESSDNYEHWLYYLDPFLHHVGWAAQQGYELQPPSAIRHLKNEAEWQEILAKVKEEEEEPLPSYLFKDKQVIGIHTFSVNMKLEAVDPWSPFGISPATVVKVFDEKYFLVEMDDLRPENHARRSFVCHADSPGIFPVQWSLKNGLHISPPPGYPSQDFDWADYLKQCGAEAAPQRCFPPLISEHEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPIPECIVSVESMDIFPLGWCETNGHPLSTPRRARVYKQRKIAVVQPEKQVPSSRTVHEGLRNQELNSTESVMINGKYCCPKIYFNHRCFSGPYLNKGRIAELPQCVGPGNCVLVLREVLTLLINAAYKPSRVLRELQLDKDSVWHGCGEVLKAKYKGKSYRATVEIVKTADRVTEFCRQTCIKLECCPNLFGPRMVLDKCSENCSVLTKTKYTHYYGKKKNKRIGRPPGGHSNLACALKKASKRRKRRKNVFVHKKKRSSASVDNTPAGSPQGSGGEDEDDPDEGDDDSLSEGSTSEQQDELQEESEMSEKKSCSSSPTQSEISTSLPPDRQRRKRELRTFSFSDDENKPPSPKEIRIEVAERLHLDSNPLKWSVADVVRFIRSTDCAPLARIFLDQEIDGQALLLLTLPTVQECMDLKLGPAIKLCHHIERIKFAFYEQFAN"},{"id":"SEQ_08441","a":"Q8WWV6","g":"FCAMR","d":"High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor","L":532,"m":[{"c":"TPAA[DG]ψW[TI][LS][GM]","u":10,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three head-to-tail tandem 10-aa repeats in the central disordered region anchored by an invariant N-terminal TPAA tetrapeptide and a conserved W following a large aliphatic residue (M/V).","i":[[365,374,"TPAAGMWTLG"],[375,384,"TPAADVWILG"],[385,394,"TPAADVWTSM"]]}],"s":"MPLFLILCLLQGSSFALPQKRPHPRWLWEGSLPSRTHLRAMGTLRPSSPLCWREESSFAAPNSLKGSRLVSGEPGGAVTIQCHYAPSSVNRHQRKYWCRLGPPRWICQTIVSTNQYTHHRYRDRVALTDFPQRGLFVVRLSQLSPDDIGCYLCGIGSENNMLFLSMNLTISAGPASTLPTATPAAGELTMRSYGTASPVANRWTPGTTQTLGQGTAWDTVASTPGTSKTTASAEGRRTPGATRPAAPGTGSWAEGSVKAPAPIPESPPSKSRSMSNTTEGVWEGTRSSVTNRARASKDRREMTTTKADRPREDIEGVRIALDAAKKVLGTIGPPALVSETLAWEILPQATPVSKQQSQGSIGETTPAAGMWTLGTPAADVWILGTPAADVWTSMEAASGEGSAAGDLDAATGDRGPQATLSQTPAVGPWGPPGKESSVKRTFPEDESSSRTLAPVSTMLALFMLMALVLLQRKLWRRRTSQEAERVTLIQMTHFLEVNPQADQLPHVERKMLQDDSLPAGASLTAPERNPGP"},{"id":"SEQ_08443","a":"Q6NT46","g":"GAGE2A","d":"G antigen 2A","L":116,"m":[{"c":"[NT]PEE[GV][EK]","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three 6-aa proline-acidic motif copies in a short disordered sequence, comprising two identical TPEEGE segments (positions 39-44 and 106-111) and an immediately adjacent head-to-tail variant NPEEVK (100-105) sharing a conserved [NT]PEE core.","i":[[39,44,"TPEEGE"],[100,105,"NPEEVK"],[106,111,"TPEEGE"]]}],"s":"MSWRGRSTYRPRPRRYVEPPEMIGPMRPEQFSDEVEPATPEEGEPATQRQDPAAAQEGQDEGASAGQGPKPEAHSQEQGHPQTGCECEDGPDGQEMDPPNPEEVKTPEEGEKQSQC"},{"id":"SEQ_08449","a":"Q13033","g":"STRN3","d":"Striatin-3","L":797,"m":[{"c":"xxxxxH(x){2,9}xxφxxxxxxxxφ[ST]xxx[DT]xxφxφΩ[NDV]","u":"32-39","sp":"periodic","x":"structured_like","cf":"high","why":"Seven C-terminal ~35-aa beta-propeller-like repeats separated by short 7-18 aa inter-blade loops, anchored by an invariant N-terminal H, conserved internal hydrophobic positions (φ), a central [ST]xxx[DT] turn motif, and a C-terminal φxφΩ[NDV] signature.","i":[[474,508,"YTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWN"],[527,561,"YTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWN"],[580,614,"GTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWN"],[626,660,"NGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYD"],[678,709,"LQSNNHINRVVSHPTLPVTITAHEDRHIKFFD"],[717,751,"HSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN"],[759,797,"QEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV"]]}],"s":"MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQYLQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQILNGGESPKQKGQEIKRSSGDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKIGNEGLAADLTDDPDTEEALKEFDFLVTAEDGEGAGEARSSGDGTEWDKDDLSPTAEVWDVDQGLISKLKEQYKKERKGKKGVKRANRTKLYDMIADLGDDELPHIPSGIINQSRSASTRMTDHEGARAEEAEPITFPSGGGKSFIMGSDDVLLSVLGLGDLADLTVTNDADYSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV"},{"id":"SEQ_08452","a":"O60936","g":"NOL3","d":"Nucleolar protein 3","L":208,"m":[{"c":"EPEPELE[PA]E[AP]","u":10,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three non-overlapping 10-aa acidic-proline repeats in the disordered C-terminal tail punctuated in exact register by a conserved hydrophobic leucine (L) anchor and constrained C-terminal [PA]E[AP] positions, separated by 8-aa and 2-aa linkers.","i":[[152,161,"EPEPELEAEA"],[170,179,"EPEPELEPEA"],[182,191,"EPEPELEPEP"]]}],"s":"MGNAQERPSETIDRERKRLVETLQADSGLLLDALLARGVLTGPEYEALDALPDAERRVRRLLLLVQGKGEAACQELLRCAQRTAGAPDPAWDWQHVGPGYRDRSYDPPCPGHWTPEAPGSGTTCPGLPRASDPDEAGGPEGSEAVQSGTPEEPEPELEAEASKEAEPEPEPEPELEPEAEAEPEPELEPEPDPEPEPDFEERDESEDS"},{"id":"SEQ_08457","a":"Q69YH5","g":"CDCA2","d":"Cell division cycle-associated protein 2","L":1023,"m":[{"c":"[ST]PxxF","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Six dispersed copies in the disordered N-terminal half share a conserved [ST]P proline-directed N-terminal anchor and fixed C-terminal F anchor, with strong internal enrichment for charged residues (D/E/K in 5/6) at position 3 and small polar residues (T/S/N in 5/6) at position 4.","i":[[47,51,"TPDTF"],[53,57,"SPLNF"],[68,72,"TPESF"],[291,295,"SPDTF"],[321,325,"TPKTF"],[400,404,"SPEVF"]]}],"s":"MDANSKDKPPETKESAMNNAGNASFILGTGKIVTPQKHAELPPNPCTPDTFKSPLNFSTVTVEQLGITPESFVRNSAGKSSSYLKKCRRRSAVGARGSPETNHLIRFIARQQNIKNARKSPLAQDSPSQGSPALYRNVNTLRERISAFQSAFHSIKENEKMTGCLEFSEAGKESEMTDLTRKEGLSACQQSGFPAVLSSKRRRISYQRDSDENLTDAEGKVIGLQIFNIDTDRACAVETSVDLSEISSKLGSTQSGFLVEESLPLSELTETSNALKVADCVVGKGSSDAVSPDTFTAEVSSDAVPDVRSPATPACRRDLPTPKTFVLRSVLKKPSVKMCLESLQEHCNNLYDDDGTHPSLISNLPNCCKEKEAEDEENFEAPAFLNMRKRKRVTFGEDLSPEVFDESLPANTPLRKGGTPVCKKDFSGLSSLLLEQSPVPEPLPQPDFDDKGENLENIEPLQVSFAVLSSPNKSSISETLSGTDTFSSSNNHEKISSPKVGRITRTSNRRNQLVSVVEESVCNLLNTEVQPCKEKKINRRKSQETKCTKRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKKPLLSPIPELPEVPEMTPSIPSIRRLGSGYFSSNGKLEEVKTPKNPVKRKDLLRHDPDLHMHQGYDKYDVSEFCSYIKSSSSLGNATSDEDPNTNIMNINENKNIPKAKNKSESENEPKAGTDSPVSCASVTEERVASDSPKPALTLQQGQEFSAGGQNAENLCQFFKISPDLNIKCERKDDFLGAAEGKLQCNRLMPNSQKDCHCLGDVLIENTKESKSQSEDLGRKPMESSSVVSCRDRKDRRRSMCYSDGRSLHLEKNGNHTPSSSVGSSVEISLENSELFKDLSDAIEQTFQRRNSETKVRRSTRLQKDLENEGLVWISLPLPSTSQKAKRRTICTFDSSGFESMSPIKETVSSRQKPQMAPPVSDPENSQGPAAGSSDEPGKRRKSFCISTLANTKATSQFKGYRRRSSLNGKGESSLTALERIEHNGERKQ"},{"id":"SEQ_08478","a":"Q07955","g":"SRSF1","d":"Serine/arginine-rich splicing factor 1","L":248,"m":[{"c":"Rψφx[GS][GN]LPPxxxxxDψxDxφxxφGxψ(x){12,13}φxFVxxED(x){20,22}ψRVxφ(x){0,2}PR","u":"74-77","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of a ~75-aa globular domain separated by a 31-aa glycine-rich linker, strongly anchored across four conserved sub-motifs: N-terminal Rψφx[GS][GN]LPP, DψxDxφxxφGxψ, central φxFVxxED, and C-terminal ψRVxφ(x){0,2}PR.","i":[[17,90,"RIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVEFEDPRDAEDAVYGRDGYDYDGYRLRVEFPR"],[122,198,"RVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRDGTGVVEFVRKEDMTYAVRKLDNTKFRSHEGETAYIRVKVDGPR"]]}],"s":"MSGGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVEFEDPRDAEDAVYGRDGYDYDGYRLRVEFPRSGRGTGRGGGGGGGGGAPRGRYGPPSRRSENRVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRDGTGVVEFVRKEDMTYAVRKLDNTKFRSHEGETAYIRVKVDGPRSPSYGRSRSRSRSRSRSRSRSNSRSRSYSPRRSRGSPRYSPRHSRSRSRT"},{"id":"SEQ_08481","a":"P12109","g":"COL6A1","d":"Collagen alpha-1(VI) chain","L":1028,"m":[{"c":"P[VAI]D[LI]x[FI][VL]LD[TSG]S[EA]S[VI][AG][LS](x){30,37}[AV][GA][AV][LV][HQ]YS(x){57,59}[LA][IL][VL]φ[TS]DG(x){18,24}[VI][KQE][VI][FV][SV]V[AGV][IV](x){6,10}[PD][RHQ][LI][SNR][IV][IL](x){35,41}[QK][VI]","u":"197-212","sp":"dispersed","x":"structured_like","cf":"high","why":"Three large (~200 aa) globular repeats share conserved hydrophobic beta-strand cores and key anchor motifs including N-terminal P[VAI]D..LDxSxS, central YS and φ[TS]DG motifs, and a C-terminal hydrophobic strand/helix module. Copy 1 is separated from tandem-adjacent copies 2 and 3 by an extended central G-x-y triplet tract (flagged separately as collagen_gxy).","i":[[35,246,"PVDLFFVLDTSESVALRLKPYGALVDKVKSFTKRFIDNLRDRYYRCDRNLVWNAGALHYSDEVEIIQGLTRMPGGRDALKSSVDAVKYFGKGTYTDCAIKKGLEQLLVGGSHLKENKYLIVVTDGHPLEGYKEPCGGLEDAVNEAKHLGVKVFSVAITPDHLEPRLSIIATDHTYRRNFTAADWGQSRDAEEAISQTIDTIVDMIKNNVEQV"],[613,809,"PIDLLFVLDSSESIGLQNFEIAKDFVVKVIDRLSRDELVKFEPGQSYAGVVQYSHSQMQEHVSLRSPSIRNVQELKEAIKSLQWMAGGTFTGEALQYTRDQLLPPSPNNRIALVITDGRSDTQRDTTPLNVLCSPGIQVVSVGIKDVFDFIPGSDQLNVISCQGLAPSQGRPGLSLVKENYAELLEDAFLKNVTAQI"],[827,1025,"PADITILLDGSASVGSHNFDTTKRFAKRLAERFLTAGRTDPAHDVRVAVVQYSGTGQQRPERASLQFLQNYTALASAVDAMDFINDATDVNDALGYVTRFYREASSGAAKKRLLLFSDGNSQGATPAAIEKAVQEAQRAGIEIFVVVVGRQVNEPHIRVLVTGKTAEYDVAYGESHLFRVPSYQALLRGVFHQTVSRKV"]]}],"s":"MRAARALLPLLLQACWTAAQDEPETPRAVAFQDCPVDLFFVLDTSESVALRLKPYGALVDKVKSFTKRFIDNLRDRYYRCDRNLVWNAGALHYSDEVEIIQGLTRMPGGRDALKSSVDAVKYFGKGTYTDCAIKKGLEQLLVGGSHLKENKYLIVVTDGHPLEGYKEPCGGLEDAVNEAKHLGVKVFSVAITPDHLEPRLSIIATDHTYRRNFTAADWGQSRDAEEAISQTIDTIVDMIKNNVEQVCCSFECQPARGPPGLRGDPGFEGERGKPGLPGEKGEAGDPGRPGDLGPVGYQGMKGEKGSRGEKGSRGPKGYKGEKGKRGIDGVDGVKGEMGYPGLPGCKGSPGFDGIQGPPGPKGDPGAFGLKGEKGEPGADGEAGRPGSSGPSGDEGQPGEPGPPGEKGEAGDEGNPGPDGAPGERGGPGERGPRGTPGTRGPRGDPGEAGPQGDQGREGPVGVPGDPGEAGPIGPKGYRGDEGPPGSEGARGAPGPAGPPGDPGLMGERGEDGPAGNGTEGFPGFPGYPGNRGAPGINGTKGYPGLKGDEGEAGDPGDDNNDIAPRGVKGAKGYRGPEGPQGPPGHQGPPGPDECEILDIIMKMCSCCECKCGPIDLLFVLDSSESIGLQNFEIAKDFVVKVIDRLSRDELVKFEPGQSYAGVVQYSHSQMQEHVSLRSPSIRNVQELKEAIKSLQWMAGGTFTGEALQYTRDQLLPPSPNNRIALVITDGRSDTQRDTTPLNVLCSPGIQVVSVGIKDVFDFIPGSDQLNVISCQGLAPSQGRPGLSLVKENYAELLEDAFLKNVTAQICIDKKCPDYTCPITFSSPADITILLDGSASVGSHNFDTTKRFAKRLAERFLTAGRTDPAHDVRVAVVQYSGTGQQRPERASLQFLQNYTALASAVDAMDFINDATDVNDALGYVTRFYREASSGAAKKRLLLFSDGNSQGATPAAIEKAVQEAQRAGIEIFVVVVGRQVNEPHIRVLVTGKTAEYDVAYGESHLFRVPSYQALLRGVFHQTVSRKVALG"},{"id":"SEQ_08483","a":"Q9H7Z3","g":"NRDE2","d":"Nuclear exosome regulator NRDE2","L":1164,"m":[{"c":"xxx[LP]Wxxφφxφ(x){7,13}xxx[FYL]xxxx","u":"26-32","sp":"dispersed","x":"structured_like","cf":"high","why":"Seven amphipathic bi-helical repeats (five canonical 29-aa units in the C-terminal half plus two N-terminal copies with slight inter-helical loop variation) are anchored by an invariant [LP]W pair and phased hydrophobic positions (φφxφ) in the first segment followed by a conserved [FYL] anchor in the second segment. Copies occur in a mix of dispersed and closely spaced/tandem arrangements.","i":[[324,349,"DTQLWMAFVAFQDEVMKSPGLYAIEE"],[414,445,"NTALWQKYLLFCQSQFSTFSISKIHSLYGKCL"],[779,807,"NFCLWKQYAHLEWLLGNTEDARKVFDTAL"],[997,1025,"NQVLWRSYVQIQNKSHSASKTRRFFDTIT"],[1030,1058,"PLEPWLFAIEAEKLRKRLVETVQRLDGRE"],[1088,1116,"CPLLWRMYLNFLVSLGNKERSKGVFYKAL"],[1117,1145,"QNCPWAKVLYLDAVEYFPDEMQEILDLMT"]]}],"s":"MALFPAFAGLSEAPDGGSSRKELDWLSNPSFCVGSITSLSQQTEAAPAHVSEGLPLTRSHLKSESSDESDTNKKLKQTSRKKKKEKKKKRKHQHHKKTKRKHGPSSSSRSETDTDSEKDKPSRGVGGSKKESEEPNQGNNAAADTGHRFVWLEDIQAVTGETFRTDKKPDPANWEYKSLYRGDIARYKRKGDSCLGINPKKQCISWEGTSTEKKHSRKQVERYFTKKSVGLMNIDGVAISSKTEPPSSEPISFIPVKDLEDAAPVTTWLNPLGIYDQSTTHWLQGQGPPEQESKQPDAQPDSESAALKAKVEEFNRRVRENPRDTQLWMAFVAFQDEVMKSPGLYAIEEGEQEKRKRSLKLILEKKLAILERAIESNQSSVDLKLAKLKLCTEFWEPSTLVKEWQKLIFLHPNNTALWQKYLLFCQSQFSTFSISKIHSLYGKCLSTLSAVKDGSILSHPALPGTEEAMFALFLQQCHFLRQAGHSEKAISLFQAMVDFTFFKPDSVKDLPTKGQVEFFEPFWDSGEPRAGEKGARGWKAWMHQQERGGWVVINPDEDDDEPEEDDQEIKDKTLPRWQIWLAAERSRDQRHWRPWRPDKTKKQTEEDCEDPERQVLFDDIGQSLIRLSSHDLQFQLVEAFLQFLGVPSGFTPPASCLYLAMDENSIFDNGLYDEKPLTFFNPLFSGASCVGRMDRLGYPRWTRGQNREGEEFIRNVFHLVMPLFSGKEKSQLCFSWLQYEIAKVIWCLHTKNKKRLKSQGKNCKKLAKNLLKEPENCNNFCLWKQYAHLEWLLGNTEDARKVFDTALGMAGSRELKDSDLCELSLLYAELEVELSPEVRRAATARAVHILTKLTESSPYGPYTGQVLAVHILKARKAYEHALQDCLGDSCVSNPAPTDSCSRLISLAKCFMLFQYLTIGIDAAVQIYEQVFAKLNSSVFPEGSGEGDSASSQSWTSVLEAITLMHTSLLRFHMKVSVYPLAPLREALSQALKLYPGNQVLWRSYVQIQNKSHSASKTRRFFDTITRSAKPLEPWLFAIEAEKLRKRLVETVQRLDGREIHATIPETGLMHRIQALFENAMRSDSGSQCPLLWRMYLNFLVSLGNKERSKGVFYKALQNCPWAKVLYLDAVEYFPDEMQEILDLMTEKELRVRLPLEELELLLED"},{"id":"SEQ_08489","a":"Q6S545","g":"POTEH","d":"POTE ankyrin domain family member H","L":545,"m":[{"c":"LRSKMGKWC[CR]HCF[AP][CW]CRGSGK[SN][NK]VG[TP][SW]GD[HY]DDSA[MF][KM][TE]","u":37,"sp":"tandem","x":"mixed","cf":"high","why":"Four head-to-tail 37-aa repeats in the N-terminal region showing near-identical sequence conservation across cysteine-aromatic (WCxHCFxxCR) and polar/acidic (GSGKxxVGxxGDxDDSA) segments.","i":[[20,56,"LRSKMGKWCRHCFAWCRGSGKSNVGTSGDHDDSAMKT"],[57,93,"LRSKMGKWCCHCFPWCRGSGKSNVGTSGDHDDSAMKT"],[94,130,"LRSKMGKWCCHCFPCCRGSGKSNVGTSGDHDDSAMKT"],[131,167,"LRSKMGKWCCHCFPCCRGSGKNKVGPWGDYDDSAFME"]]},{"c":"xx[GK]xT[AP][LR]xx[AG]xxxxxxxxxxφL[LIS]xxxxxxxxxx","u":33,"sp":"tandem","x":"structured_like","cf":"high","why":"Six contiguous 33-aa structured repeats in exact register anchored by a conserved T[AP][LR]xx[AG] motif and a hydrophobic φL[LIS] core.","i":[[208,240,"KQKRTALHLASANGNSEVVKLLLDRRCQLNILD"],[241,273,"NKKRTALTKAVQCQEDECALMLLEHGTDPNIPD"],[274,306,"EYGNTALHYAIYNEDKLMAKALLLYGADIESKN"],[307,339,"KHGLTPLLLGVHEQKQQVVKFLIKKKANLNALD"],[340,372,"RYGRTALILAVCCGSASIVSLLLEQNIDVSSQD"],[373,405,"LSGQTAREYAVSSRHNVICQLLSDYKEKQILKV"]]}],"s":"MVAEAGSMPAASSVKKPFGLRSKMGKWCRHCFAWCRGSGKSNVGTSGDHDDSAMKTLRSKMGKWCCHCFPWCRGSGKSNVGTSGDHDDSAMKTLRSKMGKWCCHCFPCCRGSGKSNVGTSGDHDDSAMKTLRSKMGKWCCHCFPCCRGSGKNKVGPWGDYDDSAFMEPRYHVRREDLDKLHRAAWWGKVPRKDLIVMLKDTDMNKKDKQKRTALHLASANGNSEVVKLLLDRRCQLNILDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTALHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSRHNVICQLLSDYKEKQILKVSSENSNPEQDLKLTSEEESQRLKGSENSQPEEMSQEPEINKGGDRKVEEEMKKHGSTHMGFPENLTNGATADNGDDGLIPPRKSRTPESQQFPDTENEQYHSDEQNDTQKQLSEEQNTGILQDEILIHEEKQIEVAENEF"},{"id":"SEQ_08499","a":"Q96IQ9","g":"ZNF414","d":"Zinc finger protein 414","L":312,"m":[{"c":"[GN]+x[FI]xC(x){2,4}CxxxF[PR][ST]xxxLφxH[LS]xx[HC]","u":"26-28","sp":"dispersed","x":"structured_like","cf":"high","why":"Three conserved 26-28 aa cysteine/histidine-anchored repeats separated by short variable linkers (8 aa and 3 aa), featuring fixed C-x(2,4)-C, F, L, and H-[LS]-x-x-[HC] positions.","i":[[106,133,"GKQIPCSSPGCCLSFPSVRDLAQHLRTH"],[142,169,"GKLFRCSALSCTETFPSMQELVAHSKLH"],[173,198,"NRYFKCENCLLRFRTHRSLFKHLHVC"]]}],"s":"MEEKPSGPIPDMLATAEPSSSETDKEVLSPAVPAAAPSSSMSEEPGPEQAATPPVWERGGAGGMQQGSSPAPDSCQPGPGPSPGLTSIVSGTSEDLRPPRRRPPPGKQIPCSSPGCCLSFPSVRDLAQHLRTHCPPTQSLEGKLFRCSALSCTETFPSMQELVAHSKLHYKPNRYFKCENCLLRFRTHRSLFKHLHVCAEHAQSPAPPPPPALDREPPAPERPPEVDPASAPGLPFPLLEPFTTPAPAPTGPFLPYLNPAPFGLSPPRLRPFLAAAPGPPASSAAVWKKSQGAGSSPRRPQGGSDAPSGACR"},{"id":"SEQ_08504","a":"Q9Y5H7","g":"PCDHA5","d":"Protocadherin alpha-5","L":936,"m":[{"c":"(x){14,25}φxxxx[AV]xDx[DG]xxxxxxψxxxφ(x){23,28}ψDx[ET](x){16,19}P(x){0,1}L(x){4,5}ψx[VI]x[VL]x-(x){4,5}Pxφ","u":"104-113","sp":"tandem","x":"structured_like","cf":"high","why":"Six head-to-tail tandem 104-113 aa structured-like repeats sharing multi-block sequence architecture: an N-terminal φxxxx[AV]xDx[DG]xxxxxxψxxxφ segment, a central ψDx[ET] motif, and a C-terminal P(x){0,1}L-led alternating aliphatic strand (ψx[VI]x[VL]x-) ending in Pxφ (with DxNDN preceding Pxφ in copies 1-5).","i":[[29,132,"QLHYSIPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKGRGDLLEVNLQNGILFVNSRIDREELCRRRAECSIHLEVIVDRPLQVFHVEVAVKDINDNPPRF"],[133,241,"SRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRLNPNEYFDLDVKTNEEETNFLELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEF"],[242,349,"DKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEM"],[350,454,"AITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAF"],[455,564,"AQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPAL"],[565,677,"LVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPFRVGLYTGEISTTRSLDETEAPRHRLLVLVKDHGEPPLTATATVLVSLVESGQAPKA"]]}],"s":"MVYSRRGSLGSRLLLLWLLLAYWKAGSGQLHYSIPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKGRGDLLEVNLQNGILFVNSRIDREELCRRRAECSIHLEVIVDRPLQVFHVEVAVKDINDNPPRFSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRLNPNEYFDLDVKTNEEETNFLELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPFRVGLYTGEISTTRSLDETEAPRHRLLVLVKDHGEPPLTATATVLVSLVESGQAPKASSRASAGAVGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAQPTEAVCTRGKPTLLCSSAVGSWSYSQQRRQRVCSGEAPPKTDLMAFSPSLPQGPTSTDNPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ"},{"id":"SEQ_08505","a":"Q9UJQ4","g":"SALL4","d":"Sal-like protein 4","L":1053,"m":[{"c":"[HFN]xCxxCxxx[FL]xxxxx[FL]xxHxxx[HC]","u":23,"sp":"dispersed","x":"structured_like","cf":"high","why":"Eight 23-aa repeats defined by invariant C at positions 3 and 6, conserved hydrophobic [FL] anchors at positions 10 and 16, invariant H at position 19, and [HC] at position 23, arranged as one N-terminal singlet plus three dispersed clusters linked internally by short 5-9 aa linkers (including conserved TGE[RK]P pairs).","i":[[72,94,"HVCEKCCAEFFSISEFLEHKKNC"],[382,404,"HKCKYCSKVFGTDSSLQIHLRSH"],[410,432,"FVCSVCGHRFTTKGNLKVHFHRH"],[566,588,"NECLICHRVLSCQSSLKMHYRTH"],[594,616,"FQCKICGRAFSTKGNLKTHLGVH"],[626,648,"HSCPICQKKFTNAVMLQQHIRMH"],[870,892,"HGCTRCGKNFSSASALQIHERTH"],[898,920,"FVCNICGRAFTTKGNLKVHYMTH"]]}],"s":"MSRRKQAKPQHINSEEDQGEQQPQQQTPEFADAAPAAPAAGELGAPVNHPGNDEVASEDEATVKRLRREETHVCEKCCAEFFSISEFLEHKKNCTKNPPVLIMNDSEGPVPSEDFSGAVLSHQPTSPGSKDCHRENGGSSEDMKEKPDAESVVYLKTETALPPTPQDISYLAKGKVANTNVTLQALRGTKVAVNQRSADALPAPVPGANSIPWVLEQILCLQQQQLQQIQLTEQIRIQVNMWASHALHSSGAGADTLKTLGSHMSQQVSAAVALLSQKAGSQGLSLDALKQAKLPHANIPSATSSLSPGLAPFTLKPDGTRVLPNVMSRLPSALLPQAPGSVLFQSPFSTVALDTSKKGKGKPPNISAVDVKPKDEAALYKHKCKYCSKVFGTDSSLQIHLRSHTGERPFVCSVCGHRFTTKGNLKVHFHRHPQVKANPQLFAEFQDKVAAGNGIPYALSVPDPIDEPSLSLDSKPVLVTTSVGLPQNLSSGTNPKDLTGGSLPGDLQPGPSPESEGGPTLPGVGPNYNSPRAGGFQGSGTPEPGSETLKLQQLVENIDKATTDPNECLICHRVLSCQSSLKMHYRTHTGERPFQCKICGRAFSTKGNLKTHLGVHRTNTSIKTQHSCPICQKKFTNAVMLQQHIRMHMGGQIPNTPLPENPCDFTGSEPMTVGENGSTGAICHDDVIESIDVEEVSSQEAPSSSSKVPTPLPSIHSASPTLGFAMMASLDAPGKVGPAPFNLQRQGSRENGSVESDGLTNDSSSLMGDQEYQSRSPDILETTSFQALSPANSQAESIKSKSPDAGSKAESSENSRTEMEGRSSLPSTFIRAPPTYVKVEVPGTFVGPSTLSPGMTPLLAAQPRRQAKQHGCTRCGKNFSSASALQIHERTHTGEKPFVCNICGRAFTTKGNLKVHYMTHGANNNSARRGRKLAIENTMALLGTDGKRVSEIFPKEILAPSVNVDPVVWNQYTSMLNGGLAVKTNEISVIQSGGVPTLPVSLGATSVVNNATVSKMDGSQSGISADVEKPSATDGVPKHQFPHFLEENKIAVS"},{"id":"SEQ_08508","a":"Q15772","g":"SPEG","d":"Striated muscle preferentially expressed protein kinase","L":3267,"m":[{"c":"[FVL]xxxxxxxx[VL](x){17,19}ψxW(x){25,35}[DH]xGφ[YL]xxx[ALI]x[NT]xx[GD](x){3,4}[CS]x[AV]x[LV]xφx","u":"82-91","sp":"dispersed","x":"structured_like","cf":"high","why":"Nine dispersed 82-91 aa globular repeats distributed across N-terminal, central, and C-terminal regions, anchored by an N-terminal [FVL] cap and conserved aliphatic position, an invariant W core, and a highly conserved C-terminal [DH]xGφ[YL]xxx[ALI]x[NT]xx[GD]...[CS]x[AV]x[LV]xφx signature.","i":[[45,126,"FLRPLKNAAVCAGSDVRLRVVVSGTPQPSLRWFRDGQLLPAPAPEPSCLWLRRCGAQDAGVYSCMAQNERGRASCEAVLTVL"],[724,812,"FEIPLQNVVVAPGADVLLKCIITANPPPQVSWHKDGSALRSEGRLLLRAEGERHTLLLREARAADAGSYMATATNELGQATCAASLTVR"],[871,960,"FKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEVR"],[970,1059,"VLAPLQDVDVGAGEMALFECLVAGPTDVEVDWLCRGRLLQPALLKCKMHFDGRKCKLLLTSVHEDDSGVYTCKLSTAKDELTCSARLTVR"],[1066,1154,"FTRLLEDVEVLEGRAARFDCKISGTPPPVVTWTHFGCPMEESENLRLRQDGGLHSLHIAHVGSEDEGLYAVSAVNTHGQAHCSAQLYVE"],[1190,1278,"FLRPLQDLEVGLAKEAMLECQVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDVHRLVFPAVGPQHAGVYKSVIANKLGKAACYAHLYVT"],[1393,1482,"LDKPDIVYVVEGQPASVTVTFNHVEAQVVWRSCRGALLEARAGVYELSQPDDDQYCLRICRVSRRDMGALTCTARNRHGTQTCSVTLELA"],[1487,1575,"FESIMEDVEVGAGETARFAVVVEGKPLPDIMWYKDEVLLTESSHVSFVYEENECSLVVLSTGAQDGGVYTCTAQNLAGEVSCKAELAVH"],[2586,2676,"FHIKLKDQVLLEGEAATLLCLPAACPAPHISWMKDKKSLRSEPSVIIVSCKDGRQLLSIPRAGKRHAGLYECSATNVLGSITSSCTVAVAR"]]},{"c":"YxxxxExxRGxFxφψRxxxExxxGxxF[AV]AKφψPxxxxxKxxxxxExxψLxxLxH-xψψxxHEAΩxxxRxLVψψxExC(x){21,22}YMxQψLxGψxYLHxxHVLHLDψKP-NLLψ(x){7,11}IxDFG[NS]AQ(x){12,14}GTxEFψAPEψVxxxPψxxxTDIWxxGVψxΩψxL[ST]GxSPF(x){32,33}FLxKVLx(x){4,5}RP[ST]xxxxLxHPW[FL]","u":"253-254","sp":"dispersed","x":"structured_like","cf":"high","why":"Two large (~253-254 aa) dispersed structured duplications separated by ~1100 aa, displaying extensive collinear conservation across numerous invariant multi-residue blocks including RGxF, F[AV]AKφψP, HEAΩ, HVLHLDψKP-NLLψ, DFG[NS]AQ, GTxEFψAPEψV, TDIWxxGV, and C-terminal HPW[FL].","i":[[1601,1854,"YDIHQEIGRGAFSYLRRIVERSSGLEFAAKFIPSQAKPKASARREARLLARLQHDCVLYFHEAFERRRGLVIVTELCTEELLERIARKPTVCESEIRAYMRQVLEGIHYLHQSHVLHLDVKPENLLVWDGAAGEQQVRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQDRLRPTAEETLEHPWF"],[2966,3218,"YTFLEEKARGRFGVVRACRENATGRTFVAKIVPYAAEGKRRVLQEYEVLRTLHHERIMSLHEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATYMVQLLQGLDYLHGHHVLHLDIKPDNLLLAPDNALKIVDFGSAQPYNPQALRPLGHRTGTLEFMAPEMVKGEPIGSATDIWGAGVLTYIMLSGRSPFYEPDPQETEARIVGGRFDAFQLYPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWL"]]}],"s":"MQKARGTRGEDAGTRAPPSPGVPPKRAKVGAGGGAPVAVAGAPVFLRPLKNAAVCAGSDVRLRVVVSGTPQPSLRWFRDGQLLPAPAPEPSCLWLRRCGAQDAGVYSCMAQNERGRASCEAVLTVLEVGDSETAEDDISDVQGTQRLELRDDGAFSTPTGGSDTLVGTSLDTPPTSVTGTSEEQVSWWGSGQTVLEQEAGSGGGTRRLPGSPRQAQATGAGPRHLGVEPLVRASRANLVGASWGSEDSLSVASDLYGSAFSLYRGRALSIHVSVPQSGLRREEPDLQPQLASEAPRRPAQPPPSKSALLPPPSPRVGKRSPPGPPAQPAATPTSPHRRTQEPVLPEDTTTEEKRGKKSKSSGPSLAGTAESRPQTPLSEASGRLSALGRSPRLVRAGSRILDKLQFFEERRRSLERSDSPPAPLRPWVPLRKARSLEQPKSERGAPWGTPGASQEELRAPGSVAERRRLFQQKAASLDERTRQRSPASDLELRFAQELGRIRRSTSREELVRSHESLRATLQRAPSPREPGEPPLFSRPSTPKTSRAVSPAAAQPPSPSSAEKPGDEPGRPRSRGPAGRTEPGEGPQQEVRRRDQFPLTRSRAIQECRSPVPPPAADPPEARTKAPPGRKREPPAQAVRFLPWATPGLEGAAVPQTLEKNRAGPEAEKRLRRGPEEDGPWGPWDRRGARSQGKGRRARPTSPELESSDDSYVSAGEEPLEAPVFEIPLQNVVVAPGADVLLKCIITANPPPQVSWHKDGSALRSEGRLLLRAEGERHTLLLREARAADAGSYMATATNELGQATCAASLTVRPGGSTSPFSSPITSDEEYLSPPEEFPEPGETWPRTPTMKPSPSQNRRSSDTGSKAPPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEVRAHPESRSLAVLAPLQDVDVGAGEMALFECLVAGPTDVEVDWLCRGRLLQPALLKCKMHFDGRKCKLLLTSVHEDDSGVYTCKLSTAKDELTCSARLTVRPSLAPLFTRLLEDVEVLEGRAARFDCKISGTPPPVVTWTHFGCPMEESENLRLRQDGGLHSLHIAHVGSEDEGLYAVSAVNTHGQAHCSAQLYVEEPRTAASGPSSKLEKMPSIPEEPEQGELERLSIPDFLRPLQDLEVGLAKEAMLECQVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDVHRLVFPAVGPQHAGVYKSVIANKLGKAACYAHLYVTDVVPGPPDGAPQVVAVTGRMVTLTWNPPRSLDMAIDPDSLTYTVQHQVLGSDQWTALVTGLREPGWAATGLRKGVQHIFRVLSTTVKSSSKPSPPSEPVQLLEHGPTLEEAPAMLDKPDIVYVVEGQPASVTVTFNHVEAQVVWRSCRGALLEARAGVYELSQPDDDQYCLRICRVSRRDMGALTCTARNRHGTQTCSVTLELAEAPRFESIMEDVEVGAGETARFAVVVEGKPLPDIMWYKDEVLLTESSHVSFVYEENECSLVVLSTGAQDGGVYTCTAQNLAGEVSCKAELAVHSAQTAMEVEGVGEDEDHRGRRLSDFYDIHQEIGRGAFSYLRRIVERSSGLEFAAKFIPSQAKPKASARREARLLARLQHDCVLYFHEAFERRRGLVIVTELCTEELLERIARKPTVCESEIRAYMRQVLEGIHYLHQSHVLHLDVKPENLLVWDGAAGEQQVRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQDRLRPTAEETLEHPWFKTQAKGAEVSTDHLKLFLSRRRWQRSQISYKCHLVLRPIPELLRAPPERVWVTMPRRPPPSGGLSSSSDSEEEELEELPSVPRPLQPEFSGSRVSLTDIPTEDEALGTPETGAATPMDWQEQGRAPSQDQEAPSPEALPSPGQEPAAGASPRRGELRRGSSAESALPRAGPRELGRGLHKAASVELPQRRSPSPGATRLARGGLGEGEYAQRLQALRQRLLRGGPEDGKVSGLRGPLLESLGGRARDPRMARAASSEAAPHHQPPLENRGLQKSSSFSQGEAEPRGRHRRAGAPLEIPVARLGARRLQESPSLSALSEAQPSSPARPSAPKPSTPKSAEPSATTPSDAPQPPAPQPAQDKAPEPRPEPVRASKPAPPPQALQTLALPLTPYAQIIQSLQLSGHAQGPSQGPAAPPSEPKPHAAVFARVASPPPGAPEKRVPSAGGPPVLAEKARVPTVPPRPGSSLSSSIENLESEAVFEAKFKRSRESPLSLGLRLLSRSRSEERGPFRGAEEEDGIYRPSPAGTPLELVRRPERSRSVQDLRAVGEPGLVRRLSLSLSQRLRRTPPAQRHPAWEARGGDGESSEGGSSARGSPVLAMRRRLSFTLERLSSRLQRSGSSEDSGGASGRSTPLFGRLRRATSEGESLRRLGLPHNQLAAQAGATTPSAESLGSEASATSGSSAPGESRSRLRWGFSRPRKDKGLSPPNLSASVQEELGHQYVRSESDFPPVFHIKLKDQVLLEGEAATLLCLPAACPAPHISWMKDKKSLRSEPSVIIVSCKDGRQLLSIPRAGKRHAGLYECSATNVLGSITSSCTVAVARVPGKLAPPEVPQTYQDTALVLWKPGDSRAPCTYTLERRVDGESVWHPVSSGIPDCYYNVTHLPVGVTVRFRVACANRAGQGPFSNSSEKVFVRGTQDSSAVPSAAHQEAPVTSRPARARPPDSPTSLAPPLAPAAPTPPSVTVSPSSPPTPPSQALSSLKAVGPPPQTPPRRHRGLQAARPAEPTLPSTHVTPSEPKPFVLDTGTPIPASTPQGVKPVSSSTPVYVVTSFVSAPPAPEPPAPEPPPEPTKVTVQSLSPAKEVVSSPGSSPRSSPRPEGTTLRQGPPQKPYTFLEEKARGRFGVVRACRENATGRTFVAKIVPYAAEGKRRVLQEYEVLRTLHHERIMSLHEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATYMVQLLQGLDYLHGHHVLHLDIKPDNLLLAPDNALKIVDFGSAQPYNPQALRPLGHRTGTLEFMAPEMVKGEPIGSATDIWGAGVLTYIMLSGRSPFYEPDPQETEARIVGGRFDAFQLYPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWLQDAYLMKLRRQTLTFTTNRLKEFLGEQRRRRAEAATRHKVLLRSYPGGP"},{"id":"SEQ_08516","a":"O43281","g":"EFS","d":"Embryonal Fyn-associated substrate","L":561,"m":[{"c":"xYxxP","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Nine dispersed 5-residue YxxP repeats clustered across the central proline-rich disordered region (residues 87-256), where all 9 tyrosines carry an invariant +3 Pro anchor, a strictly constrained Pro or large aliphatic (V/I/L) residue at -1, mostly acidic D/E at +1 (including a 4-copy Y[DV]VP core), and small/aliphatic hydrophobics (V/I/A) in 8/9 copies at +2.","i":[[87,91,"PYPAP"],[100,104,"VYVVP"],[127,131,"IYKIP"],[147,151,"VYDVP"],[162,166,"PYDCP"],[187,191,"PYDVP"],[216,220,"IYAAP"],[232,236,"LYEAP"],[252,256,"IYDVP"]]}],"s":"MAIATSTQLARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLLPAGPAPKPSLSPASPAQPGSPYPAPDHSNEDQEVYVVPPPARPCPTSGPPAGPCPPSPDLIYKIPRASGTQLAAPRDALEVYDVPPTALRVPSSGPYDCPASFSHPLTRVAPQPPGEDDAPYDVPLTPKPPAELEPDLEWEGGREPGPPIYAAPSNLKRASALLNLYEAPEELLADGEGGGTDEGIYDVPLLGPEAPPSPEPPGALASHDQDTLAQLLARSPPPPHRPRLPSAESLSRRPLPALPVPEAPSPSPVPSPAPGRKGSIQDRPLPPPPPRLPGYGGPKVEGDPEGREMEDDPAGHHNEYEGIPMAEEYDYVHLKGMDKAQGSRPPDQACTGDPELPERGMPAPQEALSPGEPLVVSTGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSKRVVVAAHRLVFVGDTLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQCVTELAGQALQFTTLLTSLAP"},{"id":"SEQ_08522","a":"O15020","g":"SPTBN2","d":"Spectrin beta chain, non-erythrocytic 2","L":2390,"m":[{"c":"(x){5,11}φxxxΩxxφxxxxxx+xxxL(x){2,17}φxxxxxxxxWψxxxxxxφ(x){4,6}[GP]xxφxxφxxφx[KRQ][HKR]xxφ(x){21,38}","u":"89-114","sp":"tandem","x":"structured_like","cf":"high","why":"Sixteen head-to-tail tandem copies of an ~106-aa structured alpha-helical repeat span residues 387-2078, anchored by two conserved aromatic/tryptophan positions (Ω and Wψ separated by ~33 residues), periodic hydrophobic core residues (φ/L), a central [GP]-containing turn, and a basic/histidine ([KRQ][HKR]) cluster.","i":[[387,497,"REGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYH"],[498,611,"DIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQL"],[612,716,"VSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGAS"],[717,822,"QASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPE"],[823,927,"VQSRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKD"],[928,1033,"RIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQA"],[1034,1140,"VAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQC"],[1141,1247,"LFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHAD"],[1248,1352,"KIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKA"],[1353,1458,"LVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGE"],[1459,1560,"VERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAG"],[1561,1663,"PELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPEST"],[1664,1769,"RISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAAR"],[1770,1876,"ATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAE"],[1877,1989,"EIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLS"],[1990,2078,"QLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTAL"]]}],"s":"MSSTLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQSRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASVPPGDLVGGQTASDTTWDGTQPRPPPSTQAPSVNGVCTDGEPSQPLLGQQRLEHSSFPEGPGPGSGDEANGPRGERQTRTRGPAPSAMPQSRSTESAHAATLPPRGPEPSAQEQMEGMLCRKQEMEAFGKKAANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSASGEPEEPVVPSTTRGMTRAMTMPPVSPVGAEGPVVLRSKDGREREREKRFSFFKKNK"},{"id":"SEQ_08533","a":"O14795","g":"UNC13B","d":"Protein unc-13 homolog B","L":1591,"m":[{"c":"ψ[CT][IV]xV[KV]xAxx[LQ](x){8,11}ΩV[ET][LV]x[MV](x){16,20}W(x){3,7}F[HM]F(x){8,12}[IL]x[IV]xV[KW][DN](x){28,37}WxxL(x){8,21}[IT]xLx[IT]xx[EI][IL]","u":"126-129","sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed ~126-129 aa structured domain repeats (N-terminal, central, and C-terminal) sharing conserved hydrophobic/beta-strand cores and aromatic anchors, including ψ[CT][IV]xV[KV]xAxx[LQ], ΩV[ET][LV]x[MV], W(x){3,7}F[HM]F, [IL]x[IV]xV[KW][DN], WxxL, and [IT]xLx[IT]xx[EI][IL].","i":[[4,129,"LCVRVKRAKFQGSPDKFNTYVTLKVQNVKSTTVAVRGDQPSWEQDFMFEISRLDLGLSVEVWNKGLIWDTMVGTVWIALKTIRQSDEEGPGEWSTLEAETLMKDDEICGTRNPTPHKILLDTRFEL"],[602,730,"ITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLQISVEI"],[1440,1565,"VTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFLLGNEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLTILRIL"]]}],"s":"MSLLCVRVKRAKFQGSPDKFNTYVTLKVQNVKSTTVAVRGDQPSWEQDFMFEISRLDLGLSVEVWNKGLIWDTMVGTVWIALKTIRQSDEEGPGEWSTLEAETLMKDDEICGTRNPTPHKILLDTRFELPFDIPEEEARYWTYKWEQINALGADNEYSSQEESQRKPLPTAAAQCSFEDPDSAVDDRDSDYRSETSNSFPPPYHTASQPNASVHQFPVPVRSPQQLLLQGSSRDSCNDSMQSYDLDYPERRAISPTSSSRYGSSCNVSQGSSQLSELDQYHEQDDDHRETDSIHSCHSSHSLSRDGQAGFGEQEKPLEVTGQAEKEAACEPKEMKEDATTHPPPDLVLQKDHFLGPQESFPEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDSMPDLRRKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYFDETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQGPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALEEHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENEDVSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRRFAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASAAQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQLIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQGSGVDDPVGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFLLGNEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLTILRILSQRSNDEVAREFVKLKSESRSTEEGS"},{"id":"SEQ_08546","a":"Q99590","g":"SCAF11","d":"Protein SCAF11","L":1463,"m":[{"c":"SP[KRN][KRN]-[TSI]x[RKQ][EG]x+[RKQ][SP][QRE][SP]x","u":16,"sp":"tandem","x":"disordered_like","cf":"high","why":"Six head-to-tail tandem 16-residue repeats in a central disordered S/P/R/K/E-rich region (residues 802-897), anchored by an invariant N-terminal SP dipeptide, an invariant acidic position (- at pos 5), an invariant basic position (+ at pos 11), and strongly conserved basic/polar positions (pos 3-4, 8-9, 12-15).","i":[[802,817,"SPNKDTPQEKKRPQSP"],[818,833,"SPRRETGKESRKSQSP"],[834,849,"SPKNESARGRKKSRSQ"],[850,865,"SPKKDIARERRQSQSR"],[866,881,"SPKRDTTRESRRSESL"],[882,897,"SPRRETSRENKRSQPR"]]}],"s":"MKKKTVCTLNMGDKKYEDMEGEENGDNTISTGLLYSEADRCPICLNCLLEKEVGFPESCNHVFCMTCILKWAETLASCPIDRKPFQAVFKFSALEGYVKVQVKKQLRETKDKKNENSFEKQVSCHENSKSCIRRKAIVREDLLSAKVCDLKWIHRNSLYSETGGKKNAAIKINKPQRSNWSTNQCFRNFFSNMFSSVSHSGESSFTYRAYCTEFIEASEISALIRQKRHELELSWFPDTLPGIGRIGFIPWNVETEVLPLISSVLPRTIFPTSTISFEHFGTSCKGYALAHTQEGEEKKQTSGTSNTRGSRRKPAMTTPTRRSTRNTRAETASQSQRSPISDNSGCDAPGNSNPSLSVPSSAESEKQTRQAPKRKSVRRGRKPPLLKKKLRSSVAAPEKSSSNDSVDEETAESDTSPVLEKEHQPDVDSSNICTVQTHVENQSANCLKSCNEQIEESEKHTANYDTEERVGSSSSESCAQDLPVLVGEEGEVKKLENTGIEANVLCLESEISENILEKGGDPLEKQDQISGLSQSEVKTDVCTVHLPNDFPTCLTSESKVYQPVSCPLSDLSENVESVVNEEKITESSLVEITEHKDFTLKTEELIESPKLESSEGEIIQTVDRQSVKSPEVQLLGHVETEDVEIIATCDTFGNEDFNNIQDSENNLLKNNLLNTKLEKSLEEKNESLTEHPRSTELPKTHIEQIQKHFSEDNNEMIPMECDSFCSDQNESEVEPSVNADLKQMNENSVTHCSENNMPSSDLADEKVETVSQPSESPKDTIDKTKKPRTRRSRFHSPSTTWSPNKDTPQEKKRPQSPSPRRETGKESRKSQSPSPKNESARGRKKSRSQSPKKDIARERRQSQSRSPKRDTTRESRRSESLSPRRETSRENKRSQPRVKDSSPGEKSRSQSRERESDRDGQRRERERRTRKWSRSRSHSRSPSRCRTKSKSSSFGRIDRDSYSPRWKGRWANDGWRCPRGNDRYRKNDPEKQNENTRKEKNDIHLDADDPNSADKHRNDCPNWITEKINSGPDPRTRNPEKLKESHWEENRNENSGNSWNKNFGSGWVSNRGRGRGNRGRGTYRSSFAYKDQNENRWQNRKPLSGNSNSSGSESFKFVEQQSYKRKSEQEFSFDTPADRSGWTSASSWAVRKTLPADVQNYYSRRGRNSSGPQSGWMKQEEETSGQDSSLKDQTNQQVDGSQLPINMMQPQMNVMQQQMNAQHQPMNIFPYPVGVHAPLMNIQRNPFNIHPQLPLHLHTGVPLMQVATPTSVSQGLPPPPPPPPPSQQVNYIASQPDGKQLQGIPSSSHVSNNMSTPVLPAPTAAPGNTGMVQGPSSGNTSSSSHSKASNAAVKLAESKVSVAVEASADSSKTDKKLQIQEKAAQEVKLAIKPFYQNKDITKEEYKEIVRKAVDKVCHSKSGEVNSTKVANLVKAYVDKYKYSRKGSQKKTLEEPVSTEKNIG"},{"id":"SEQ_08558","a":"Q14511","g":"NEDD9","d":"Enhancer of filamentation 1","L":834,"m":[{"c":"φY[DQA][VI]Pxx","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Eleven dispersed copies across the central Pro/Gly-rich disordered region (residues 91-350) share invariant Y2 and P5 anchors, a flanking N-terminal hydrophobic residue (predominantly V/I, often preceded by G), constrained [DQA]3 and [VI]4 core positions, and a C-terminal PP[ST] preference in seven copies (with two additional divergent variants VYEYPSR and DYDFPPP nearby).","i":[[91,97,"LYQVPNP"],[105,111,"IYQVPPS"],[117,123,"IYQVPTG"],[131,137,"VYQVPPS"],[176,182,"VYDIPPS"],[188,194,"VYDIPPS"],[213,219,"VYDIPPT"],[222,228,"VYAIPPS"],[260,266,"VYDIPPT"],[316,322,"AYDVPRG"],[344,350,"VYDVPLH"]]}],"s":"MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPMQETASSHEQPASGLMQQTFGQQKLYQVPNPQAAPRDTIYQVPPSYQNQGIYQVPTGHGTQEQEVYQVPPSVQRSIGGTSGPHVGKKVITPVRTGHGYVYEYPSRYQKDVYDIPPSHTTQGVYDIPPSSAKGPVFSVPVGEIKPQGVYDIPPTKGVYAIPPSACRDEAGLREKDYDFPPPMRQAGRPDLRPEGVYDIPPTCTKPAGKDLHVKYNCDIPGAAEPVARRHQSLSPNHPPPQLGQSVGSQNDAYDVPRGVQFLEPPAETSEKANPQERDGVYDVPLHNPPDAKGSRDLVDGINRLSFSSTGSTRSNMSTSSTSSKESSLSASPAQDKRLFLDPDTAIERLQRLQQALEMGVSSLMALVTTDWRCYGYMERHINEIRTAVDKVELFLKEYLHFVKGAVANAACLPELILHNKMKRELQRVEDSHQILSQTSHDLNECSWSLNILAINKPQNKCDDLDRFVMVAKTVPDDAKQLTTTINTNAEALFRPGPGSLHLKNGPESIMNSTEYPHGGSQGQLLHPGDHKAQAHNKALPPGLSKEQAPDCSSSDGSERSWMDDYDYVHLQGKEEFERQQKELLEKENIMKQNKMQLEHHQLSQFQLLEQEITKPVENDISKWKPSQSLPTTNSGVSAQDRQLLCFYYDQCETHFISLLNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVTAQDIRNKVMNSSNQLCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF"},{"id":"SEQ_08575","a":"O15013","g":"ARHGEF10","d":"Rho guanine nucleotide exchange factor 10","L":1369,"m":[{"c":"-[ES]xIYD[DL][VL]","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed copies in the N- and C-terminal disordered tails share an invariant IYD core flanked by a conserved N-terminal acidic residue (D/E), [ES] at position 2, and C-terminal [DL][VL] aliphatic-rich positions.","i":[[235,242,"EEAIYDDV"],[252,259,"DEMIYDDV"],[1303,1310,"DSTIYDLL"]]}],"s":"MRPPGFLSRAPSLNRAERGIWSCSMDQREPLPPAPAENEMKYDTNNNEEEEGEQFDFDSGDEIPEADRQAPSAPETGGAGASEAPAPTGGEDGAGAETTPVAEPTKLVLPMKVNPYSVIDITPFQEDQPPTPVPSAEEENVGLHVPCGYLVPVPCGYAVPSNLPLLLPAYSSPVIICATSLDEEAETPEVTEDRQPNSLSSEEPPTSEDQVGREDSALARWAADPANTAWMENPEEAIYDDVPRENSDSEPDEMIYDDVENGDEGGNSSLEYGWSSSEFESYEEQSDSECKNGIPRSFLRSNHKKQLSHDLTRLKEHYEKKMRDLMASTVGVVEIQQLRQKHELKMQKLVKAAKDGTKDGLERTRAAVKRGRSFIRTKSLIAQDHRSSLEEEQNLFIDVDCKHPEAILTPMPEGLSQQQVVRRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKVLSERKLKTVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKQEQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHDSRVMSSQRYLLKWSVPLGHVDAIEYGSSAGTGEHSRHLAVHPPESLAVVANAKPNKVYMGPGQLYQDLQNLLHDLNVIGQITQLIGNLKGNYQNLNQSVAHDWTSGLQRLILKKEDEIRAADCCRIQLQLPGKQDKSGRPTFFTAVFNTFTPAIKESWVNSLQMAKLALEEENHMGWFCVEDDGNHIKKEKHPLLVGHMPVMVAKQQEFKIECAAYNPEPYLNNESQPDSFSTAHGFLWIGSCTHQMGQIAIVSFQNSTPKVIECFNVESRILCMLYVPVEEKRREPGAPPDPETPAVRASDVPTICVGTEEGSISIYKSSQGSKKVRLQHFFTPEKSTVMSLACTSQSLYAGLVNGAVASYARAPDGSWDSEPQKVIKLGVLPVRSLLMMEDTLWAASGGQVFIISVETHAVEGQLEAHQEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLPGHQRLSVTSLLVCHGLLMVGTSLGVLVALPVPRLQGIPKVTGRGMVSYHAHNSPVKFIVLATALHEKDKDKSRDSLAPGPEPQDEDQKDALPSGGAGSSLSQGDPDAAIWLGDSLGSMTQKSDLSSSSGSLSLSHGSSSLEHRSEDSTIYDLLKDPVSLRSKARRAKKAKASSALVVCGGQGHRRVHRKARQPHQEELAPTVMVWQIPLLNI"},{"id":"SEQ_08576","a":"O14545","g":"TRAFD1","d":"TRAF-type zinc finger domain-containing protein 1","L":582,"m":[{"c":"C(x){1,2}CxxxφxxxxφxxH(x){3,5}C","u":"20-22","sp":"dispersed","x":"structured_like","cf":"high","why":"Seven C2HC-type repeats (five clustered near the N-terminus with 3-6 aa linkers and two dispersed centrally) share invariant C-C-H-C metal-coordinating anchors, a strict 11-residue central segment with two conserved hydrophobic core positions, and minor 1-2 or 3-5 residue loop variation.","i":[[13,32,"CDNCKKEIPVFNFTIHEIHC"],[39,60,"CPTCKEPFPKSDMETHMAAEHC"],[64,83,"CKCNKKLEKRLLKKHEETEC"],[90,109,"CQHCDLELSILKLKEHEDYC"],[116,135,"CGNCGRNVLVKDLKTHPEVC"],[293,312,"CEFCEELYPEELLIDHQTSC"],[370,389,"CEFCGVQLEEEVLFHHQDQC"]]}],"s":"MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHCQVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNCGRNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDPPMRLPRRPLRAFESDVFHNRTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGEESANLDFMLALSLQNEGQASSVAEQDFWRAVCEADQSHGGPRSLSDIKGAADEIMLPCEFCEELYPEELLIDHQTSCNPSRALPSLNTGSSSPRGVEEPDVIFQNFLQQAASNQLDSLMGLSNSHPVEESIIIPCEFCGVQLEEEVLFHHQDQCDQRPATATNHVTEGIPRLDSQPQETSPELPRRRVRHQGDLSSGYLDDTKQETANGPTSCLPPSRPINNMTATYNQLSRSTSGPRPGCQPSSPCVPKLSNSDSQDIQGRNRDSQNGAIAPGHVSVIRPPQNLYPENIVPSFSPGPSGRYGASGRSEGGRNSRVTPAAANYRSRTAKAKPSKQQGAGDAEEEEEE"},{"id":"SEQ_08584","a":"Q2M3V2","g":"SOWAHA","d":"Ankyrin repeat domain-containing protein SOWAHA","L":549,"m":[{"c":"[SG]GΩT[AP]LHφAAxxG(x){1,2}ExAφxLψxV(x){2,4}GA[PQ]V[DH]V[NR][AD][RH]S[HG]","u":"36-39","sp":"tandem","x":"structured_like","cf":"high","why":"Two strongly conserved 36-39 aa tandem repeats (residues 345-419) anchored by an N-terminal [SG]GΩT[AP]LHφAA motif, a hydrophobic core (AφxLψxV), and a conserved C-terminal GA[PQ]V[DH]V[NR][AD][RH]S[HG] segment.","i":[[345,383,"SGFTALHWAAKSGDGEMALQLVEVARRSGAPVDVNARSH"],[384,419,"GGYTPLHLAALHGHEDAAVLLVVRLGAQVHVRDHSG"]]}],"s":"MALAAAAAAAAAGVSQAAVLGFLQEHGGKVRNSELLSRFKPLLDAGDPRGRAARRDRFKQFVNNVAVVKELDGVKFVVLRKKPRPPEPEPAPFGPPGAAAQPSKPTSTVLPRSASAPGAPPLVRVPRPVEPPGDLGLPTEPQDTPGGPASEPAQPPGERSADPPLPALELAQATERPSADAAPPPRAPSEAASPCSDPPDAEPGPGAAKGPPQQKPCMLPVRCVPAPATLRLRAEEPGLRRQLSEEPSPRSSPLLLRRLSVEESGLGLGLGPGRSPHLRRLSRAGPRLLSPDAEELPAAPPPSAVPLEPSEHEWLVRTAGGRWTHQLHGLLLRDRGLAAKRDFMSGFTALHWAAKSGDGEMALQLVEVARRSGAPVDVNARSHGGYTPLHLAALHGHEDAAVLLVVRLGAQVHVRDHSGRRAYQYLRPGSSYALRRLLGDPGLRGTTEPDATGGGSGSLAARRPVQVAATILSSTTSAFLGVLADDLMLQDLARGLKKSSSFSKFLSASPMAPRKKTKIRGGLPAFSEISRRPTPGPLAGLVPSLPPTT"},{"id":"SEQ_08592","a":"O75475","g":"PSIP1","d":"PC4 and SFRS1-interacting protein","L":530,"m":[{"c":"[PKR]RGR[PK]","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 5-aa repeats clustered in the central polar/proline-rich disordered region (residues 147-199), sharing an invariant RGR core flanked by basic/proline residues and each preceded closely by a PK dipeptide.","i":[[146,150,"RRGRK"],[179,183,"KRGRP"],[193,197,"PRGRP"]]}],"s":"MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETEISLKDSTLDN"},{"id":"SEQ_08596","a":"A6NDE8","g":"GAGE12H","d":"G antigen 12H","L":117,"m":[{"c":"Exx[ST][PQ]E[EQ]G[EH][PK][AQ][ST][GQ]C","u":14,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 14-aa repeats in the P/E/Q/G-rich C-terminal disordered region (residues 37-117) anchored by invariant E (pos 1, 6), G (pos 8), and C-terminal C (pos 14) positions along with conserved [ST] positions (pos 4, 12); copies 1 and 3 are particularly closely related across TPEEGE.","i":[[37,50,"EPATPEEGEPATQC"],[73,86,"EAHSQEQGHPQTGC"],[104,117,"EVKTPEEGEKQSQC"]]}],"s":"MSWRGRSTYYWPRPRRYVQPPEMIGPMRPEQFSDEVEPATPEEGEPATQCQDPAAAQKGEDEGASAGQGPKPEAHSQEQGHPQTGCECEDGPDGQEMDPPNPEEVKTPEEGEKQSQC"},{"id":"SEQ_08600","a":"Q8N8E2","g":"ZNF513","d":"Zinc finger protein 513","L":541,"m":[{"c":"[FY]xCxxCx[FY]x[SCT]xxxx[NH][LY]xRHxxxH","u":23,"sp":"dispersed","x":"structured_like","cf":"high","why":"Eight 23-aa C2H2-like repeats arranged in two clusters (3 and 5 copies separated internally by conserved 5-aa [ST]G[ED]KP linkers and split by a 131-aa middle region), anchored by invariant CxxC, R, and HxxxH positions alongside [FY] aromatic anchors.","i":[[150,172,"YSCRLCTFVSHYSSHLKRHMQTH"],[178,200,"FRCGRCPYASAQLVNLTRHTRTH"],[206,228,"YRCPHCPFACSSLGNLRRHQRTH"],[360,382,"FACSLCPFATHYPNHLARHMKTH"],[388,410,"FRCARCPYASAHLDNLKRHQRVH"],[416,438,"YKCPLCPYACGNLANLKRHGRIH"],[444,466,"FRCSLCNYSCNQSMNLKRHMLRH"],[472,494,"FRCATCAYTTGHWDNYKRHQKVH"]]}],"s":"MPRRKQSHPQPVKCEGVKVDTEDSLDEGPGALVLESDLLLGQDLEFEEEEEEEEGDGNSDQLMGFERDSEGDSLGARPGLPYGLSDDESGGGRALSAESEVEEPARGPGEARGERPGPACQLCGGPTGEGPCCGAGGPGGGPLLPPRLLYSCRLCTFVSHYSSHLKRHMQTHSGEKPFRCGRCPYASAQLVNLTRHTRTHTGEKPYRCPHCPFACSSLGNLRRHQRTHAGPPTPPCPTCGFRCCTPRPARPPSPTEQEGAVPRRPEDALLLPDLSLHVPPGGASFLPDCGQLRGEGEGLCGTGSEPLPELLFPWTCRGCGQELEEGEGSRLGAAMCGRCMRGEAGGGASGGPQGPSDKGFACSLCPFATHYPNHLARHMKTHSGEKPFRCARCPYASAHLDNLKRHQRVHTGEKPYKCPLCPYACGNLANLKRHGRIHSGDKPFRCSLCNYSCNQSMNLKRHMLRHTGEKPFRCATCAYTTGHWDNYKRHQKVHGHGGAGGPGLSASEGWAPPHSPPSVLSSRGPPALGTAGSRAVHTDSS"},{"id":"SEQ_08616","a":"A6NNT2","g":"C16orf96","d":"Uncharacterized protein C16orf96","L":1141,"m":[{"c":"KD[GVD][AVD]PK[DE][RA]xx","u":10,"sp":"tandem","x":"disordered_like","cf":"high","why":"Eight head-to-tail tandem 10-aa repeats in a charged disordered region composed of alternating KD[GVD][AVD]P and KDRxx (7/8 copies) sub-motifs with invariant K, D, and P anchors.","i":[[475,484,"KDGAPKDRTR"],[485,494,"KDGVPKDRGG"],[495,504,"KDVDPKDRAH"],[505,514,"KDDVPKDRGG"],[515,524,"KDVDPKDRAH"],[525,534,"KDDVPKDRGG"],[535,544,"KDGDPKDRVG"],[545,554,"KDGAPKEAQP"]]},{"c":"WPxxxx","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Six 6-aa motifs in the upstream proline-rich disordered region (four tightly clustered in a tandem/quasi-tandem array at residues 386-410 and two flanking copies) anchored by an invariant WP dipeptide followed by hydrophobic/basic [LRVA] and [LPVW] positions.","i":[[367,372,"WPVLGP"],[386,391,"WPALPR"],[393,398,"WPLPQG"],[399,404,"WPRVGS"],[405,410,"WPLWDL"],[434,439,"WPRPLQ"]]}],"s":"MSFSLTFTELANIAIPQCGVLNFKALHLLLHGILEHIHMAELKKVLSGDEDFLQTSQVVIMPREGDAQPILNPMKRLSNVFDHVVSRLDKLENQLALLQDLPSTAQLLEASQGTARPVQDLWHLIKLRKMVEGHDEVMAKSMQTLQDLLTDLHALQVTITALRKEVDMLKNMLDKVHPERMDIFAEDFKIQNWKMVALQREVASLQNKFKTIPKTEDMVLWSGLHDAMFTSEIGSSPLDLWQSVEQLPEAALAQTTKYLEATRAIQVSEPVQNPQLLQTVWHYEVPELLPEGSSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPVLGPVPAPGAQPPPLGDWPALPRRWPLPQGWPRVGSWPLWDLGVLRPTQPQPSRAPPPATEFGSLWPRPLQPYQSRQGEALQLAAVQVKGEENDVPSLRGLRERARKDGAPKDRTRKDGVPKDRGGKDVDPKDRAHKDDVPKDRGGKDVDPKDRAHKDDVPKDRGGKDGDPKDRVGKDGAPKEAQPKAPQSALHRLKTTAAIAAAAAAAYAAATSSAAQAAKVAAKFVKDAPATKMAAIATDTAAAGPLGVFADVLGAGPSRGATESQILGDDSEIYEILSPSYSAASIGPDPALSQAMVATKQAMSPEDKKRAVKYSMSHIAQIPVKHDSLKEEFAQLSCNLNQRLSYLANMGGPSSLGTTVDILQKKIGSLQKSRLKEEELERIWGNQIEMMKDRYITLDKAVENLQIRMDEFKTLQAQIKRLEMNKVNKSTMEEELREKADRSALAGKASRVDLETVALELNEMIQGILFKVTIHEDSWKKAMEELSKDVNTKLVHSDLDPLKKEMEEVWKIVRKLLIEGLRLDPDSAAGFRRKLFKRVKCISCDRPVEMMTGPQLITIRKAHLLSRLRPASANSCEYLQRQQMREQQWLQLQDLGIQEDCQQDWGDGPQNATSLKCKSCNLLTLYPYGDPHVIDYDSAEVDILGVDGILYKGRVNSQRGAQPLAVAKELAAVKAPSPPSQSLYDRVHSSALFGAICPPLCPRSSACSAASGPHLTMPARPPSLPPLLLLPPLIPSLRDPQQAPGSTRLSRAPHIESRVGRKPPEEPANP"},{"id":"SEQ_08623","a":"P0C7V8","g":"DCAF8L2","d":"DDB1- and CUL4-associated factor 8-like protein 2","L":631,"m":[{"c":"xx(x){3,5}φxxφxx(x){6,8}[LF][ALV]xxxxD(x){2,3}[VI]xxφxxxx","u":"34-37","sp":"periodic","x":"structured_like","cf":"high","why":"Seven periodic ~34-37 aa beta-propeller-like repeats separated by short 8-21 aa linkers, anchored by conserved hydrophobic strand positions (φxxφ, [LF][ALV], [VI]xxφ, often W/F/Y) and an invariant central Asp (D).","i":[[226,259,"DHVGCVNTVHFNQRGTRLASSGDDLKVIVWDWVR"],[269,304,"GHTNNVFQAKFLPNCGDSTLAMCARDGQVRVAELIN"],[316,350,"QHRGPAHKLALEPDSPYKFLTSGEDAVVFTIDLRQ"],[364,398,"DKKVGLYTITVNPANTYQFAVGGQDQFVRIYDQRK"],[420,453,"DFPTNITCVVYSHDGTELLASYNDDDIYLFNSSH"],[465,501,"GHRNNTTVKGVNFYGPRSEFVVSGSDCGHIFFWEKSS"],[510,544,"GSREGTINCLEPHPYLPVLACSGLDHDVKIWTPTA"]]}],"s":"MSHQEGSTDGLPDLGTESLFSSPEEQSGAVAATEASSDIDIATSELSVTVTGDGSDSRDGGFPNDASTENRSSDQESASEDIELESLEDFEHFLMSGESLFHYPLVGEEETEREEEDEEIQEEGGEEEEEEEEEEEEEEEEEEEEEEQPRAGPQGSGGNHEQYSLEEDQALEEWVSSETSALPRPRWQVVTALHQRQLGSRPRFVYEACGARAFVQRFRLQYRLADHVGCVNTVHFNQRGTRLASSGDDLKVIVWDWVRQRPVLNFESGHTNNVFQAKFLPNCGDSTLAMCARDGQVRVAELINASYFNNTKCVAQHRGPAHKLALEPDSPYKFLTSGEDAVVFTIDLRQDRPASKVVVTRENDKKVGLYTITVNPANTYQFAVGGQDQFVRIYDQRKIDKKENNGVLKKFTPHHLVNCDFPTNITCVVYSHDGTELLASYNDDDIYLFNSSHSDGAQYSKRFKGHRNNTTVKGVNFYGPRSEFVVSGSDCGHIFFWEKSSCQIIQFLKGSREGTINCLEPHPYLPVLACSGLDHDVKIWTPTAKAATELTGLKKVIKKNKWERDEDSLHHGSLFDQYMLWFLLRHVTQRGRHQDWRSGEAEFPDEESDESSSTSETSEEEVQDRVQCMPS"},{"id":"SEQ_08627","a":"O00401","g":"WASL","d":"Actin nucleation-promoting factor WASL","L":505,"m":[{"c":"+xALLDQIR[EQ]G[AI]QLKxV","u":17,"sp":"dispersed","x":"mixed","cf":"high","why":"Two highly conserved 17 aa amphipathic helical repeats separated by an 11 aa linker in the C-terminal region, sharing 12 identical positions (ALLDQIR, G, QLK, V) plus conserved N-terminal basic (+) and internal [EQ]/[AI] substitutions.","i":[[406,422,"KAALLDQIREGAQLKKV"],[434,450,"RDALLDQIRQGIQLKSV"]]},{"c":"PPPPP[SAN]R","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five clustered copies of a 7 aa proline-rich motif within the central disordered region, anchored at the C-terminus by a small/polar [SAN] position (predominantly Ser) and an invariant Arg (R).","i":[[278,284,"PPPPPSR"],[299,305,"PPPPPAR"],[310,316,"PPPPPSR"],[323,329,"PPPPPSR"],[335,341,"PPPPPNR"]]}],"s":"MSSVQQQPPPPRRVTNVGSLLLTPQENESLFTFLGKKCVTMSSAVVQLYAADRNCMWSKKCSGVACLVKDNPQRSYFLRIFDIKDGKLLWEQELYNNFVYNSPRGYFHTFAGDTCQVALNFANEEEAKKFRKAVTDLLGRRQRKSEKRRDPPNGPNLPMATVDIKNPEITTNRFYGPQVNNISHTKEKKKGKAKKKRLTKADIGTPSNFQHIGHVGWDPNTGFDLNNLDPELKNLFDMCGISEAQLKDRETSKVIYDFIEKTGGVEAVKNELRRQAPPPPPPSRGGPPPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLGVGPVAPPPPPPPPPPPGPPPPPGLPSDGDHQVPTTAGNKAALLDQIREGAQLKKVEQNSRPVSCSGRDALLDQIRQGIQLKSVADGQESTPPTPAPTSGIVGALMEVMQKRSKAIHSSDEDEDEDDEEDFEDDDEWED"},{"id":"SEQ_08630","a":"Q13435","g":"SF3B2","d":"Splicing factor 3B subunit 2","L":895,"m":[{"c":"[GS][TAV]PVPR","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 6 aa proline-basic motifs occurring in proline-rich/inter-domain linker regions, sharing an invariant PVPR core preceded by small [GS][TAV] residues (with the first two copies sharing an extended MG[TA]PVPRP octamer).","i":[[200,205,"GTPVPR"],[240,245,"GAPVPR"],[497,502,"SVPVPR"]]}],"s":"MATEHPEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQTGIVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFPMAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMGAPVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDARSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKKPQRVRGVSSESSGDREKDSTRSRGSDSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKLENSAAPKKKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDVTAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREALQEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETRLKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSPIPESCSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGELEPSDEESSEEEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAGMETPELIELRKKKIEEAMDGSETPQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGPAPELQGVEVALAPEELELDPMAMTQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQKKRKAQPQDSRGGSKKYKEFKF"},{"id":"SEQ_08632","a":"A8MU46","g":"SMTNL1","d":"Smoothelin-like protein 1","L":494,"m":[{"c":"[AEG]S[QG][EQK](x){7,8}[KS]xEPK[EA]xxx[KED]E[ESD][AT][KL]x","u":"26-27","sp":"tandem","x":"disordered_like","cf":"high","why":"Four 26-27 aa repeats in the central E/K/A/P-rich disordered region anchored by an N-terminal S[QG] motif, an invariant internal EPK[EA] motif, and a conserved C-terminal [KED]E[ESD][AT][KL]x motif; copies 2-4 are strictly head-to-tail tandem while copy 1 lies 13 aa upstream across a half-repeat linker.","i":[[107,133,"GSQEMTGRKEETKSEPKEAEEKESTLA"],[147,173,"ESGQKADANDRDKPEPKATVEEEDAKT"],[174,200,"ASQEETGQRKECSTEPKEKATDEEAKA"],[201,226,"ESQKAVVEDEAKAEPKEPDGKEEAKH"]]}],"s":"MEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYRSLVQKGLVKTKKK"},{"id":"SEQ_08636","a":"Q8IX03","g":"WWC1","d":"Protein KIBRA","L":1113,"m":[{"c":"ELPL(x){0,2}GWEEAxDxxxxxYΩIDHoo+TToφxDPRxxΩ","u":"35-37","sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved N-terminal 35-37 aa structured domain repeats separated by a 12 aa linker, sharing 19 identical positions (including ELPL, GWEEA, IDH, TT, and DPR) plus conserved aromatic and polar/basic positions.","i":[[5,41,"ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRY"],[54,88,"ELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQW"]]}],"s":"MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVHLQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIKSLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAEKVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPRKWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLHSQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSKVEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSLSSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQLGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGATRIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDASDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRWYNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLEDSWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSPTVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVRNSLERRSVRMKRPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKELKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKDVHRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV"},{"id":"SEQ_08656","a":"Q8NCU4","g":"CCDC191","d":"Coiled-coil domain-containing protein 191","L":936,"m":[{"c":"x[AV]xx[HF][YCS]xxx[LI][LQ][KRW][KRI](x){1,2}φxxW[FLK]xxxxxx[KLQ]x","u":"27-28","sp":"periodic","x":"structured_like","cf":"high","why":"Five closely spaced 27-28 aa helical repeats in the C-terminal region separated by 0-7 aa linkers, anchored by conserved [AV], [HF], [LI][LQ], a mostly basic dyad, a conserved hydrophobic position (φ), and an invariant tryptophan (W).","i":[[739,766,"IAKEHYERVLLRKKGLEPWKRLRMQSKQ"],[770,796,"VAEEHYSLFLQRKYMLTWFQRSQESLA"],[801,827,"QADQFYSQILLKRVIQSWLQYVIDLQE"],[828,854,"EVRKFCVHFLQKKIFRAWFNMVREVKI"],[862,888,"IAAEHSDRRILWITLRTWKKFVKFMKE"]]}],"s":"MLLAPQGRSFSKKRMGLNRWKRFTRKPSPKPTFGPDSVEHWIKRVEKASEFAVSNAFFTRNSDLPRSPWGQITDLKTSEQIEDHDEIYAEAQELVNDWLDTKLKQELASEEEGDAKNTVSSVTIMPEANGHLKYDKFDDLCGYLEEEEESTTVQKFIDHLLHKNVVDSAMMEDLGRKENQDKKQQKDPRLTMEMRHKQVKENRLRREKELEYQRIEKTLKKSAFLEAQCLVQEEKKRKALEAKKEEEEIQREMVKLRREIIERRRTVKAAWKIEKKRQEENSQNSSEKVMFQSTHILPDEEKMVKERKRKLKEVLIQTFKENQQCQKRYFAAWHKLILDHRIKLGKAGTLSDWKIQLKVLRAWRDYTRFQKLERETQALENDLREENRKQQLATEYNRKQVLRHCFTEWQHWHGAELLKRELALTKEETRKKMDALLQAASLGKLSANGLSGISLPEEATAMVGPPVKNGQETAVPPLWEKPPLGSSGCMLSPPLGRTTTGNLQGSLQNVSLSAPGNKQHKTLGAEPSQQPGSNETLRTTSQKAEPLCLGHFHNRHVFQQQLIEKQKKKLQEQQKTILELKKNLQLAEAQWAAEHALAVTEAQSHLLSKPREEEPRTCQMLVNSPVASPGTEGRSDSRNSLSGLRRKPKQLMTPHPILKAMEERAIQRAECRRILAEKKKKQEEEKLAQLKAQEEERQKREAEEKEAQLERKREEKRLKKMKELEKQKRIKRNQQLEAIAKEHYERVLLRKKGLEPWKRLRMQSKQNIQVAEEHYSLFLQRKYMLTWFQRSQESLARKMAQADQFYSQILLKRVIQSWLQYVIDLQEEVRKFCVHFLQKKIFRAWFNMVREVKIDSQGKHEIAAEHSDRRILWITLRTWKKFVKFMKEERVKEERRQQLRRKVVEILPDFQVPGRYHELYQQSDTWSLSKTSLVNE"},{"id":"SEQ_08659","a":"Q569K4","g":"ZNF385B","d":"Zinc finger protein 385B","L":471,"m":[{"c":"C[ENS]ψCxψxφNSxxQ[AL][EQK]xHxx[GS][KRS][KRS]H[KRA]x[KRM]V","u":27,"sp":"dispersed","x":"structured_like","cf":"high","why":"Four dispersed 27 aa repeats separated by variable disordered linkers (36-101 aa), sharing invariant CxxC, NSxxQ, HxxxxH, and C-terminal V anchors alongside conserved aliphatic/hydrophobic core positions and basic residues.","i":[[36,62,"CEVCNIQLNSAAQAQVHSNGKSHRKRV"],[159,185,"CNVCQLRFNSDSQAEAHYKGSKHAKKV"],[287,313,"CSLCKVAVNSLSQLEAHNTGSKHKTMV"],[350,376,"CEICDVHVNSEIQLKQHISSRRHKDRV"]]}],"s":"MNMANFLRGFEEKGIKNDRPEDQLSKEKKKILFSFCEVCNIQLNSAAQAQVHSNGKSHRKRVKQLSDGQPPPPAQASPSSNSSTGSTCHTTTLPALVRTPTLMMQPSLDIKPFMSFPVDSSSAVGLFPNFNTMDPVQKAVINHTFGVSIPPKKKQVISCNVCQLRFNSDSQAEAHYKGSKHAKKVKALDATKNKPKMVPSKDSAKANPSCSITPITGNNSDKSEDKGKLKASSSSQPSSSESGSFLLKSGTTPLPPGAATSPSKSTNGAPGTVVESEEEKAKKLLYCSLCKVAVNSLSQLEAHNTGSKHKTMVEARNGAGPIKSYPRPGSRLKMQNGSKGSGLQNKTFHCEICDVHVNSEIQLKQHISSRRHKDRVAGKPLKPKYSPYNKLQRSPSILAAKLAFQKDMMKPLAPAFLSSPLAAAAAVSSALSLPPRPSASLFQAPAIPPALLRPGHGPIRATPASILFAPY"},{"id":"SEQ_08680","a":"Q8N377","g":"YJ004_HUMAN","d":"Putative uncharacterized protein LOC387726","L":158,"m":[{"c":"TPA[SN][SC][SG][ST]AAPP","u":11,"sp":"tandem","x":"disordered_like","cf":"high","why":"Six head-to-tail tandem 11-residue repeats in the N-terminal Pro/Ser/Thr/Ala-rich disordered region, anchored by invariant TPA and AAPP motifs flanking a 4-residue [SN][SC][SG][ST] segment.","i":[[13,23,"TPASSSSAAPP"],[24,34,"TPASSSSAAPP"],[35,45,"TPASSSSAAPP"],[46,56,"TPANCSTAAPP"],[57,67,"TPANCSTAAPP"],[68,78,"TPASSGSAAPP"]]}],"s":"MDFRQISPTTCTTPASSSSAAPPTPASSSSAAPPTPASSSSAAPPTPANCSTAAPPTPANCSTAAPPTPASSGSAAPPTPAPDHWWMEAPHHWLPGLLARCGSRQLPSSVGLACFGTAAVPRKPVNWACQGSHGELEASQVGSGKAGPCTPHPSLLGF"},{"id":"SEQ_08686","a":"O43149","g":"ZZEF1","d":"Zinc finger ZZ-type and EF-hand domain-containing protein 1","L":2961,"m":[{"c":"-ψψNψ-φ[ST]CDxCxxψφxx[HR]RφxCxxCxDφDLCxxCΩφ","u":37,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two ungapped 37-residue cysteine-rich modules separated by a 12-aa linker, anchored by seven strictly aligned cysteines (CDxC...CxxC...CxxC), conserved N, D, R, and L positions, and a conserved N-terminal -ψψNψ-φ[ST] motif.","i":[[1775,1811,"DLLNVDISCDGCDEIAPWHRYRCLQCSDMDLCKTCFL"],[1824,1860,"EMVNMEFTCDHCQGLIIGRRMNCNVCDDFDLCYGCYA"]]},{"c":"+ESHxYxNNxxxxxxφxxPGAxYφxψxFDxxCxTExxxDxLxφ(x){17,18}KW(x){6,8}GxxLxΩxFxSDxSxoEWGY+FTVTAxxL","u":"98-99","sp":"dispersed","x":"structured_like","cf":"high","why":"Dispersed ~98-99 aa internal domain duplication separated by ~1500 residues, sharing strongly conserved N-terminal (+ESHxYxNN and PGAxYφxψxFDxxCxTE), central KW, and C-terminal (LxΩxFxSDxSxoEWGY+FTVTAxxL) sequence blocks with minor loop-length variation.","i":[[1097,1195,"KESAHNYENNCHEVSVFVSPGATYFEVEFDDRCETEKRYDYLEFTDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHSDSSHNEWGYKFTVTACGL"],[2702,2799,"RESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDELAMSSSSDFQQDRHSFSGSQQKWKDFELPGDTLYYRFTSDMSNTEWGYRFTVTAGHL"]]}],"s":"MGNAPSHSSEDEAAAAGGEGWGPHQDWAAVSGTTPGPGVAAPALPPAAALLEPARLREAAAALLPTPPCESLVSRHRGALFRWLEERLGRGEESVTLEQFRELLEARGAGCSSEQFEEAFAQFDAEGDGTVDAENMLEALKNSSGANLQGELSHIIRQLQACSLVPGFTDIFSESKEGLDIHSSMILRFLHRNRLSSAVMPYPMLEHCNNMCTMRSSVLKESLDQLVQKEKESPGDLTRSPEMDKLKSVAKCYAYIETSSNSADIDKMTNGETSSYWQSDGSACSHWIRLKMKPDVVLRHLSIAVAATDQSYMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDTRIHGLRAVGFQRVKKSGVSVSDASAIWYWSLLTSLVTASMETNPAFVQTVLHNTQKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAFALARGSVAKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKYGKPLQLTLQACDVKGKEDKSGPENLLVEPWTRDGFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIGAQCGLVFAYNSSSDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGWFELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLTISGYLRPARAEAEQSVTCAHCRKDTEESVCGATLLLRTLQFIQQLAHDLVQQKESGLKYKSFLDFAGLDLQIFWNFYSKLKQNPREECVSAQTLLLQLLQSCFSVLQGDVLAASEEEKAPIQSPKGVEAAKELYTHLCDVVDKVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRRNHLFTMMNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLAKMNISEVLAVMDTLVSVAARECELLMLSGAPGEVGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDLAVDLIEKYVGQFLASMRAILESLFSQYSGKTIVERLCNSVFSMAARQLVIFLLDFCTLDIPHCVLLREFSVLTELLKKLCSGPEGGLRKLDVETWQQEQPVVLHTWTKESAHNYENNCHEVSVFVSPGATYFEVEFDDRCETEKRYDYLEFTDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHSDSSHNEWGYKFTVTACGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVRQLGSNMVVPQAKMALVLSSPLWKPVFRHQVCPELELEASWPTHPHRNSKEVKNIPDDPCRHFLLDFAQSEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQKYVNSGGKIALSEEFAQVYSLADGIRIWMLEMKQKSLMSLGNEAEEKHSSEATEVNPESLAKECIEKSLLLLKFLPTGISSKESCEKLETADETSHLQPLNKRQRTSSVVEEHFQASVSPTEAAPPATGDQSPGLGTQPKLPSSSGLPAADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSMEEARLVPTVKEKYPVLKDVMDFIKDQSLSHRSVVKVLSLRKAQAQSILEVLKITQHCAESLGQPHCFHPPFILFLLELLTCQKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSLNDRSLLPALSCVQTALLHLLDMGWEPNDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSEWMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVDISCDGCDEIAPWHRYRCLQCSDMDLCKTCFLGGVKPEGHGDDHEMVNMEFTCDHCQGLIIGRRMNCNVCDDFDLCYGCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASAEDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGKGLKALALLGVLPDGDSSLEDQALPVTVPTGASEEQLEKKAVQGAELSEAGNGKRAVHEEIRPVDFKQRNKADKGVSLSKDPSCQTQISDSPADASPPTGLPDAEDSEVSSQKPIEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGPTVPLIDLEHVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDSSIVPDGWKTTHLLFSLGAVCLDSRVGLDWACSMAEILRSLNSAPLWRDVIATFTDHCIKQLPFQLKHTNIFTLLVLVGFPQVLCVGTRCVYMDNANEPHNVIILKHFTEKNRAVIVDVKTRKRKTVKDYQLVQKGGGQECGDSRAQLSQYSQHFAFIASHLLQSSMDSHCPEAVEATWVLSLALKGLYKTLKAHGFEEIRATFLQTDLLKLLVKKCSKGTGFSKTWLLRDLEILSIMLYSSKKEINALAEHGDLELDERGDREEEVERPVSSPGDPEQKKLDPLEGLDEPTRICFLMAHDALNAPLHILRAIYELQMKKTDYFFLEVQKRFDGDELTTDERIRSLAQRWQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISSTESELQQSYAKQRRSKSAALLHKELNCKSKRAVRDYLFRVNEATAVLYARHVLASLLAEWPSHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLGTMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDELAMSSSSDFQQDRHSFSGSQQKWKDFELPGDTLYYRFTSDMSNTEWGYRFTVTAGHLGRFQTGFEILKQMLSEERVVPHLPLAKIWEWLVGVACRQTGHQRLKAIHLLLRIVRCCGHSDLCDLALLKPLWQLFTHMEYGLFEDVTQPGILLPLHRALTELFFVTENRAQELGVLQDYLLALTTDDHLLRCAAQALQNIAAISLAINYPNKATRLWNVEC"},{"id":"SEQ_08699","a":"Q9Y3R0","g":"GRIP1","d":"Glutamate receptor-interacting protein 1","L":1128,"m":[{"c":"xx[VT]xφ(x){6,7}[LF]Gφxψ(x){8,14}ψ(x){14,17}ψxx[GY]Dxψx[ASQ]ψ[ND](x){10}[EDL]φxxφ[LI](x){6,8}φxLxψx","u":"80-88","sp":"dispersed","x":"structured_like","cf":"high","why":"Seven 80-88 aa globular repeat units distributed in clusters (three N-terminal, three central, and one C-terminal) separated by short 13-17 aa linkers within clusters and long 137-251 aa disordered linkers between clusters. Each copy shares an invariant multi-element core including an N-terminal [LF]Gφxψ motif, a central ψxx[GY]Dxψx[ASQ]ψ[ND] signature with an invariant Asp, an amphipathic [EDL]φxxφ[LI] segment, and a C-terminal φxLxψx hydrophobic motif with an invariant Leu.","i":[[52,133,"TVVELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVE"],[151,235,"VEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIE"],[251,333,"LLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEIL"],[471,558,"TEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIE"],[572,655,"FHVKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIR"],[672,752,"YTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIK"],[1004,1083,"KVTLYKDSDMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGGLKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVIS"]]}],"s":"MIAVSFKCRCQILRRLTKDESPYTKSASQTKPPDGALAVRRQSIPEEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHVKIQRSDRQLTWDSWASNHSSLHTNHHYNTYHPDHCRVPALTFPKAPPPNSPPALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAVDSWDGSAIDTSYGTQGTSFQASGYNFNTYDWRSPKQRGSLSPVTKPRSQTYPDVGLSYEDWDRSTASGFAGAADSAETEQEENFWSQALEDLETCGQSGILRELEEKADRRVSLRNMTLLATIMSGSTMSLNHEAPTPRSQLGRQASFQERSSSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSDMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGGLKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISRNPLASQKSIDQQSLPGDWSEQNSAFFQQPSHGGNLETREPTNTL"},{"id":"SEQ_08704","a":"Q8TDT2","g":"GPR152","d":"Probable G protein-coupled receptor 152","L":470,"m":[{"c":"[DN][PLS][TVM][AL]QP[QR]x","u":8,"sp":"tandem","x":"disordered_like","cf":"high","why":"Seven head-to-tail 8-aa repeats in the C-terminal P/Q/S/T-rich disordered tail anchored by an invariant QP dipeptide, conserved [AL]QP[QR] core, and strictly alternating D/N start and hydrophobic/S end positions forming a higher-order 16-aa dimeric pattern.","i":[[353,360,"DPVAQPQV"],[361,368,"NPTLQPRS"],[369,376,"DPTAQPQL"],[377,384,"NPTAQPQS"],[385,392,"DPTAQPQL"],[393,400,"NLMAQPQS"],[401,408,"DSVAQPQA"]]}],"s":"MDTTMEADLGATGHRPRTELDDEDSYPQGGWDTVFLVALLLLGLPANGLMAWLAGSQARHGAGTRLALLLLSLALSDFLFLAAAAFQILEIRHGGHWPLGTAACRFYYFLWGVSYSSGLFLLAALSLDRCLLALCPHWYPGHRPVRLPLWVCAGVWVLATLFSVPWLVFPEAAVWWYDLVICLDFWDSEELSLRMLEVLGGFLPFLLLLVCHVLTQATACRTCHRQQQPAACRGFARVARTILSAYVVLRLPYQLAQLLYLAFLWDVYSGYLLWEALVYSDYLILLNSCLSPFLCLMASADLRTLLRSVLSSFAAALCEERPGSFTPTEPQTQLDSEGPTLPEPMAEAQSQMDPVAQPQVNPTLQPRSDPTAQPQLNPTAQPQSDPTAQPQLNLMAQPQSDSVAQPQADTNVQTPAPAASSVPSPCDEASPTPSSHPTPGALEDPATPPASEGESPSSTPPEAAPGAGPT"},{"id":"SEQ_08706","a":"Q53TS8","g":"CATSPERT","d":"Cation channel sperm-associated targeting subunit tau","L":1820,"m":[{"c":"[SG]Q[IV]Ix[NA][IF]P[AEI][DY][ST][FL][SL]E[GS]","u":15,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five 15-aa repeats anchored by fixed Q2, I4, P8, and E14 plus strongly conserved aliphatic/aromatic ([IV]3, [IF]7, [FL]12) and polar ([SG]1, [ST]11, [GS]15) positions; four copies form a head-to-tail tandem array (residues 749-808) followed by a fifth dispersed copy 118 aa downstream (residues 927-941) in a P/S/E/K-rich disordered region.","i":[[749,763,"SQIIKNIPADSFSEG"],[764,778,"SQIIENIPADSLLEG"],[779,793,"GQVIKNIPEYSLSEG"],[794,808,"GQIIKNIPADSFLES"],[927,941,"SQIIQAFPIDTLLES"]]},{"c":"LSxxLxxΩLxxLSEoEψxHLKx-LSKxψQxφφψE+LSxSGxψTKxxLxxIxQxψxLψN","u":58,"sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of a 58-aa amphipathic helical segment separated by 110 aa, sharing 27 identical anchors (including LS, LSE, HLK, LSK, Q, E+LSxSG, TK, L, I, Q, L, N) and 11 additional conserved hydrophobic/polar/charged positions with zero gaps.","i":[[1129,1186,"LSPKLRVFLEELSESEVKHLKSELSKQIQHYLVERLSESGHITKEDLPKIYQNLYLMN"],[1298,1355,"LSKSLQNYLIALSENELLHLKADLSKHLQSLFIEKLSKSGLMTKKQLEGINQHINLLN"]]}],"s":"MEPPQETNRPFSTLDNRSGQVQVLSATPLLQRNPYSSPDIMHIKGSEASSVPYALNQGTTALPKNKNQEGTGHRLLNMLRKTLKESDSEELEITQETPNLVPFGDVVGCLGIHIKNCRHFMPKISLQHYANLFIRISINKAVKCTKMCSLLSKNDEKNTVIKFDEVKYFSVQVPRRYDDKRNNILLELIQYDNREKRAFLLGSVQIHLYEVIQKGCFIEEVQVLHGNIFVCRLEVEFMFSYGNFGYGFSHQLKPLQKITEPSMFMNLAPPPERTDPVTKVITPQTVEYPAFLSPDLNVTVGTPAVQSSNQPSVVRLEKLQQQPRERLEKMKKEYRNLNTWIDKANYLESILMPKLEHKDSEETNIDEASENTKSNHPEEELENIVGVDIPLVNEEAETTANELLDNDSEKGLTIPTLNQSDQDNSTADASKNDESTPSPTEVHSLCTISNQETIKAGRIPPLGERQSESMPDRKMKNVFFPLEVKLKDNYPSILKADSSLSEVAFSPKEYNSPSFRPEYIEFKPKFQFQKFNKNGFDPFLRNINKMSVRKRKDQDIYKYRNILGAEVIEHEDQDPPYPAQSKTAGPANTTWAHDPNIFTTKMLETENKLAPDPTINTIKGLDTKNSLKENLPNVSLPSIKGESSRAGNVQANTCHLSKSLNFTPHIEYLKQSMILKSILSENLQDLSDKLFSKPEVSMNSEAREKSSSPLLSIHDKSSSSMEDNVLEKKQDLNNWLSEKDILNSKTTLSQIIKNIPADSFSEGSQIIENIPADSLLEGGQVIKNIPEYSLSEGGQIIKNIPADSFLESGPGQSPEVEEHVSKKHFEADERDFPIKKNSSTKKKHLISEVPNSKSGSSGTVHDYIMRQIFTAPIFSELEIEVKEPSETPMNLENQLPTPWKRSLSSHILFHEENADEIELPQPRSATSQIIQAFPIDTLLESGIIKVIELDKEHHKSSLLGTGITSPKGNLKDSQEYYSEIRSETEPLSEQSIPIIPKDTTSVSRAEFIQEDQNMFPQDSSYYSIANKELYLPRNGQRLCKDKNDLSSTLESLTNSLMDKLSESDEIMLKSFLKNIFNVFFKYNHSERRGQPEKELERLIQPSFTSDTEHLEELQEDFDKADKLDRKPILSPKLRVFLEELSESEVKHLKSELSKQIQHYLVERLSESGHITKEDLPKIYQNLYLMNEKAEQKGPNSFQGKYSETVKEIMSFVNNFNHHFIDKHLEIKLRSFLKEILQNYFLKNISESSLFNETASETIYPNISSLRTKSVSISFHELEQDISKGSFGRRFEINMKYPLSKSLQNYLIALSENELLHLKADLSKHLQSLFIEKLSKSGLMTKKQLEGINQHINLLNSSSIPLKYIKTHLPFRDDCHFVEKHSEKQNKYSRIVQQTTLQTVSEDKLREAELIREKEKKYFPLQNLKGNSSLIKEQKSYYTKEEAKTPSLIKVQPSSNENIQASPLSKSSEILTDILLKKLRKEHVFTQLPQAENSVHKTEIQDPYSWGGKSKITQSKAWCEKTLKMKSLDRKEHVNIYKWTVQEKPEAVLTSYPRIPNARMPREDEYLNRITFPSWQSSTLTHFNTETGEKSKLEDQYCQTLKGNNNNNKKHLVTFAQYKKEIQTLYIKPDEICSEKCAKFPEIQSFQYKVVEDEKNLKPHLFPELFKIEDLKPKVRKERDRVAQPKKSFNKIVRILPTTLPTTRIHLKKSVPRTLLHWTARRTIHDCSDKFEDLHDMTSFTHLKKVKSRSRLLGKSSDDIHNHARHSARPYTAPEVNKQRESYSGKFTSRRMVSSGLVHINDKTSDYEMHKMRPKKIKRGY"},{"id":"SEQ_08709","a":"Q9NW68","g":"BSDC1","d":"BSD domain-containing protein 1","L":430,"m":[{"c":"[AV]VKEK(x){0,5}SSxAxExMK+xL[TS]-FxxV[VI]","u":"24-29","sp":"dispersed","x":"structured_like","cf":"high","why":"Strongly conserved N-terminal internal duplication of a 24-29 aa helical motif separated by a 13-aa linker, sharing 13 identical anchors (VKEK, SS, A, E, MK, L, F, V) and 5 conservative substitutions ([AV], +, [TS], -, [VI]) across a 0-5 aa variable loop.","i":[[20,43,"AVKEKSSEALEFMKRDLTEFTQVV"],[57,85,"VVKEKLATEGSSGATEKMKKGLSDFLGVI"]]}],"s":"MAEGEDVGWWRSWLQQSYQAVKEKSSEALEFMKRDLTEFTQVVQHDTACTIAATASVVKEKLATEGSSGATEKMKKGLSDFLGVISDTFAPSPDKTIDCDVITLMGTPSGTAEPYDGTKARLYSLQSDPATYCNEPDGPPELFDAWLSQFCLEEKKGEISELLVGSPSIRALYTKMVPAAVSHSEFWHRYFYKVHQLEQEQARRDALKQRAEQSISEEPGWEEEEEELMGISPISPKEAKVPVAKISTFPEGEPGPQSPCEENLVTSVEPPAEVTPSESSESISLVTQIANPATAPEARVLPKDLSQKLLEASLEEQGLAVDVGETGPSPPIHSKPLTPAGHTGGPEPRPPARVETLREEAPTDLRVFELNSDSGKSTPSNNGKKGSSTDISEDWEKDFDLDMTEEEVQMALSKVDASGELEDVEWEDWE"},{"id":"SEQ_08719","a":"Q7M4L6","g":"SHF","d":"SH2 domain-containing adapter protein F","L":423,"m":[{"c":"YxxPΩ-","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed copies in the N-terminal disordered region share an invariant N-terminal Tyr and pos-4 Pro followed by a conserved aromatic residue (F/Y/W) and C-terminal acidic residue (D/E), with polar/acidic residues (D/E/T/Q) at position 3.","i":[[108,113,"YADPFD"],[137,142,"YMEPYE"],[164,169,"YDTPYE"],[201,206,"YDQPWE"]]}],"s":"MQQEGGPVRSAPCRTGTLEGSRQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHREPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL"},{"id":"SEQ_08733","a":"Q96D71","g":"REPS1","d":"RalBP1-associated Eps domain-containing protein 1","L":796,"m":[{"c":"ψ[ST]Dx[EQ]xxYYx[DN]xF(x){17,18}EφFxxxxLPxxxψxxIφELxxφx+xGφφxxx[QE]FxφAφ[KH]LVφφxxoGΩxL","u":"79-80","sp":"dispersed","x":"structured_like","cf":"high","why":"Two dispersed copies of a ~80-residue structured domain anchored by conserved D, YY, F, EφF, LP, IφEL, Gφφ, F, A, LV, and GΩxL positions across both halves, separated by a ~195-residue disordered linker.","i":[[6,85,"LSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPL"],[281,359,"ITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDL"]]},{"c":"P[PL][PA][PV]PP+P","u":8,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed proline-rich motifs in the C-terminal disordered region sharing an upstream P[PL][PA][PV] segment and an invariant PP+P core (the only three PP[KR]P occurrences in the protein, with the first two extending identically as PPxxPPRPQPS).","i":[[546,553,"PPPPPPRP"],[584,591,"PPAVPPRP"],[695,702,"PLAPPPKP"]]}],"s":"MEGLTLSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHAASYSSDSENQGSYSGVIPPPPGRGQVKKGSVSHDTVQPRTSADAQEPASPVVSPQQSPPTSPHTWRKHSRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHSPPPPQENWVSFADTPPTSTLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEQWETFSERSSSSQTLTQFDSNIAPADPDTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNPTSPLLVKPSDLLEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGSNVTRQRSHSGTSPDNTAPPPPPPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPAVHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQDDEAEKHPEVLPAEKASDPASSLRVAKTDSKTEEKTAASAPANVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDVLEERISLEVQLEQLRPFSHL"},{"id":"SEQ_08734","a":"Q8IZX4","g":"TAF1L","d":"Transcription initiation factor TFIID subunit 1-like","L":1826,"m":[{"c":"SxIL-oIψ(x){5,6}ψPx[ST]xPFHxPVNxKφVxDYYKψIxxPψDL[EQ]TψRxNψxKxxYxSRExFx-xψxLIψxNSφxYNGPxxoφTxxxQxψψxψCxxxψxEx--xLxxLEKxI","u":"110-111","sp":"dispersed","x":"structured_like","cf":"high","why":"Two highly conserved ~110-residue globular domain copies separated by a 12-aa linker, sharing invariant signature blocks (PFHxPVN, DYYK, PψDL[EQ]TψRxN, SRExF, NSφxYNGP, C, LEKxI) and conserved hydrophobic core positions throughout, with a single 1-residue loop length difference near the N-terminus.","i":[[1405,1514,"SSILESIINDMRDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAI"],[1527,1637,"SFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNICYQTITEYDEHLTQLEKDI"]]}],"s":"MRPGCDLLLRAAATVTAAIMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDDECKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDESQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSESGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVAEWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLADENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLDDDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQGLRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAKVSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSREWEEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQEEELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNICYQTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTSRDASVFQDESNLSVLDISTATPEKQMCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPAPEGGDGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDVGYGGIRPKQPFMLQHASGEHKDGHGK"},{"id":"SEQ_08742","a":"O43159","g":"RRP8","d":"Ribosomal RNA-processing protein 8","L":456,"m":[{"c":"S[DA]S[EA]E[EDV][EGV](x){1,2}[RG]K+KC[QPH]K[QKH][AG][PSL]xx","u":"20-21","sp":"tandem","x":"disordered_like","cf":"high","why":"Four head-to-tail 20-21 aa tandem repeats in the N-terminal disordered region anchored by an N-terminal S[DA]S[EA]E acidic patch and a strongly conserved [RG]K+KC[QPH]K[QKH][AG] basic-cysteine core, with a 1-2 residue length variation in the central spacer.","i":[[62,82,"SDSEEEEEERKKKCPKKASFA"],[83,103,"SASAEVGKKGKKKCQKQGPPC"],[104,123,"SDSEEEVERKKKCHKQALVG"],[124,143,"SDSAEDEKRKRKCQKHAPIN"]]}],"s":"MFEEPEWAEAAPVAAGLGPVISRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLCISDSEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQALVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPPHTLSRKQWRNRQKNKRRCKNKFQPPQVPDQAPAEAPTEKTEVSPVPRTDSHEARAGALRARMAQRLDGARFRYLNEQLYSGPSSAAQRLFQEDPEAFLLYHRGFQSQVKKWPLQPVDRIARDLRQRPASLVVADFGCGDCRLASSIRNPVHCFDLASLDPRVTVCDMAQVPLEDESVDVAVFCLSLMGTNIRDFLEEANRVLKPGGLLKVAEVSSRFEDVRTFLRAVTKLGFKIVSKDLTNSHFFLFDFQKTGPPLVGPKAQLSGLQLQPCLYKRR"},{"id":"SEQ_08761","a":"Q9BQE9","g":"BCL7B","d":"B-cell CLL/lymphoma 7 protein family member B","L":202,"m":[{"c":"[EQ]P[PV][TP]Lxx[EQ]","u":8,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three 8-aa proline-leucine motifs clustered in the C-terminal disordered region sharing fixed P2 and L5 anchors, flanking [EQ] residues at positions 1 and 8, and a constrained [PV][TP] dipeptide core.","i":[[135,142,"QPPTLGQE"],[157,164,"EPPTLTKE"],[165,172,"EPVPLETQ"]]}],"s":"MSGRSVRAETRSRAKDDIKKVMAAIEKVRKWEKKWVTVGDTSLRIFKWVPVTDSKEKEKSKSNSSAAREPNGFPSDASANSSLLLEFQDENSNQSSVSDVYQLKVDSSTNSSPSPQQSESLSPAHTSDFRTDDSQPPTLGQEILEEPSLPSSEVADEPPTLTKEEPVPLETQVVEEEEDSGAPPLKRFCVDQPTVPQTASES"},{"id":"SEQ_08768","a":"Q71H61","g":"ILDR2","d":"Immunoglobulin-like domain-containing receptor 2","L":639,"m":[{"c":"CxCCPxSCCC","u":10,"sp":"periodic","x":"mixed","cf":"medium","why":"Two closely spaced juxtamembrane 10-aa cysteine-rich repeats separated by a 3-aa linker (YVR) that share 8 of 10 identical anchor residues (six cysteines, P5, and S7), making chance occurrence implausible.","i":[[209,218,"CQCCPHSCCC"],[222,231,"CPCCPDSCCC"]]}],"s":"MDRVLLRWISLFWLTAMVEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQGSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPEWVFVGLVLLGVFLFFVLVGICWCQCCPHSCCCYVRCPCCPDSCCCPQALYEAGKAAKAGYPPSVSGVPGPYSIPSVPLGGAPSSGMLMDKPHPPPLAPSDSTGGSHSVRKGYRIQADKERDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAMEYNKEDRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHEARGGSRFERSESRAHSGFYQDDSLEEYYGQRSRSREPLTDADRGWAFSPARRRPAEDAHLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYYAWSPPGTYKAGSSQDDQEDASDDALPPYSELELTRGPSYRGRDLPYHSNSEKKRKKEPAKKTNDFPTRMSLVV"},{"id":"SEQ_08771","a":"P19419","g":"ELK1","d":"ETS domain-containing protein Elk-1","L":428,"m":[{"c":"[ST]P[SV][LSV]L","u":5,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five non-overlapping copies in the Pro/Ser/Thr-rich C-terminal disordered region anchored by invariant P2 and L5, strict [ST]1 and [SV]3 choices, and [LSV]4 (with an upstream L also preceding four of five copies); includes one head-to-tail pair (TPVLL-TPSSL) and three variably spaced copies.","i":[[324,328,"SPSLL"],[353,357,"TPSLL"],[363,367,"TPVLL"],[368,372,"TPSSL"],[417,421,"TPVVL"]]}],"s":"MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSTMPNVAPAAIHAAPGDTVSGKPGTPKGAGMAGPGGLARSSRNEYMRSGLYSTFTIQSLQPQPPPHPRPAVVLPSAAPAGAAAPPSGSRSTSPSPLEACLEAEEAGLPLQVILTPPEAPNLKSEELNVEPGLGRALPPEVKVEGPKEELEVAGERGFVPETTKAEPEVPPQEGVPARLPAVVMDTAGQAGGHAASSPEISQPQKGRKPRDLELPLSPSLLGGPGPERTPGSGSGSGLQAPGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP"},{"id":"SEQ_08793","a":"Q9Y5U2","g":"TSSC4","d":"U5 small nuclear ribonucleoprotein TSSC4","L":329,"m":[{"c":"G[GL][AQ]EVEALS(x){9,20}GL[LP]P(x){1,2}TV(x){1,2}FH(x){3,9}[QK]RSRD[IH]F","u":"39-56","sp":"dispersed","x":"disordered_like","cf":"high","why":"Two-copy dispersed internal duplication between the N- and C-terminal disordered-like regions sharing collinear conserved blocks (GxxEVEALS, GL[LP]P, TV, FH, and [QK]RSRD[IH]F; 18 identical anchor positions overall) separated by variable P/G/S-rich linkers.","i":[[42,97,"GGAEVEALSPMGLPGEEDSGPDEPPSPPSGLLPATVQPFHLRGMSSTFSQRSRDIF"],[277,315,"GLQEVEALSGSVHSGSVPGLPPVETVGFHGSRKRSRDHF"]]}],"s":"MAEAGTGEPSPSVEGEHGTEYDTLPSDTVSLSDSDSDLSLPGGAEVEALSPMGLPGEEDSGPDEPPSPPSGLLPATVQPFHLRGMSSTFSQRSRDIFDCLEGAARRAPSSVAHTSMSDNGGFKRPLAPSGRSPVEGLGRAHRSPASPRVPPVPDYVAHPERWTKYSLEDVTEVSEQSNQATALAFLGSQSLAAPTDCVSSFNQDPSSCGEGRVIFTKPVRGVEARHERKRVLGKVGEPGRGGLGNPATDRGEGPVELAHLAGPGSPEAEEWGSHHGGLQEVEALSGSVHSGSVPGLPPVETVGFHGSRKRSRDHFRNKSSSPEDPGAEV"},{"id":"SEQ_08797","a":"Q9NR99","g":"MXRA5","d":"Matrix-remodeling-associated protein 5","L":2828,"m":[{"c":"[GE]xxxxφxCxxxxxxxxxxxW(x){20,29}[GR]xLxφxxxxxx-x[GV]x[YL]xCx[AVM]x[NVT]xx[GE](x){11,12}","u":"77-85","sp":"dispersed","x":"structured_like","cf":"high","why":"Twelve ~80-residue globular repeat units (two N-proximal copies and a ten-copy C-terminal array separated by ~17-21 aa linkers) anchored by invariant Cys and Trp in the N-terminal half and a conserved GxLxφ......-xGxYxC motif in the C-terminal half.","i":[[494,573,"GGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQ"],[592,669,"GESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITVT"],[1868,1947,"ETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTV"],[1965,2043,"GDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVA"],[2062,2140,"GLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQ"],[2161,2239,"GGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVV"],[2258,2342,"GGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVV"],[2361,2437,"GDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNV"],[2459,2536,"GSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVL"],[2557,2634,"GHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVG"],[2652,2730,"GETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIA"],[2748,2828,"GNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHVF"]]},{"c":"x[LI]xxxxφ(x){2,10}φxxψxxφxφxxNxφx","u":"24-32","sp":"tandem","x":"structured_like","cf":"high","why":"Seven contiguous head-to-tail 24-aa repeats (one 32-aa copy with an 8-residue loop insertion) near the N-terminus featuring a periodic hydrophobic spine and an invariant Asn anchor.","i":[[45,68,"SLASVPAGIAKHVERINLGFNSIQ"],[69,92,"ALSETSFAGLTKLELLMIHGNEIP"],[93,116,"SIPDGALRDLSSLQVFKFSYNKLR"],[117,140,"VITGQTLQGLSNLMRLHIDHNKIE"],[141,164,"FIHPQAFNGLTSLRLLHLEGNLLH"],[165,196,"QLHPSTFSTFTFLDYFRLSTIRHLYLAENMVR"],[197,220,"TLPASMLRNMPLLENLYLQGNPWT"]]},{"c":"xQSSx[SK]F","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three closely clustered 7-residue copies at the C-terminal end of the central Ser/Pro/Thr-rich disordered region anchored by invariant Gln at position 2, a central SS pair, and C-terminal Phe.","i":[[1812,1818,"TQSSISF"],[1823,1829,"VQSSGSF"],[1830,1836,"HQSSSKF"]]}],"s":"MPKRAHWGALSVVLILLWGHPRVALACPHPCACYVPSEVHCTFRSLASVPAGIAKHVERINLGFNSIQALSETSFAGLTKLELLMIHGNEIPSIPDGALRDLSSLQVFKFSYNKLRVITGQTLQGLSNLMRLHIDHNKIEFIHPQAFNGLTSLRLLHLEGNLLHQLHPSTFSTFTFLDYFRLSTIRHLYLAENMVRTLPASMLRNMPLLENLYLQGNPWTCDCEMRWFLEWDAKSRGILKCKKDKAYEGGQLCAMCFSPKKLYKHEIHKLKDMTCLKPSIESPLRQNRSRSIEEEQEQEEDGGSQLILEKFQLPQWSISLNMTDEHGNMVNLVCDIKKPMDVYKIHLNQTDPPDIDINATVALDFECPMTRENYEKLWKLIAYYSEVPVKLHRELMLSKDPRVSYQYRQDADEEALYYTGVRAQILAEPEWVMQPSIDIQLNRRQSTAKKVLLSYYTQYSQTISTKDTRQARGRSWVMIEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITVTKKGSGLPSKRGRRPGAKALSRVREDIVEDEGGSGMGDEENTSRRLLHPKDQEVFLKTKDDAINGDKKAKKGRRKLKLWKHSEKEPETNVAEGRRVFESRRRINMANKQINPERWADILAKVRGKNLPKGTEVPPLIKTTSPPSLSLEVTPPFPAISPPSASPVQTVTSAEESSADVPLLGEEEHVLGTISSASMGLEHNHNGVILVEPEVTSTPLEEVVDDLSEKTEEITSTEGDLKGTAAPTLISEPYEPSPTLHTLDTVYEKPTHEETATEGWSAADVGSSPEPTSSEYEPPLDAVSLAESEPMQYFDPDLETKSQPDEDKMKEDTFAHLTPTPTIWVNDSSTSQLFEDSTIGEPGVPGQSHLQGLTDNIHLVKSSLSTQDTLLIKKGMKEMSQTLQGGNMLEGDPTHSRSSESEGQESKSITLPDSTLGIMSSMSPVKKPAETTVGTLLDKDTTTATTTPRQKVAPSSTMSTHPSRRRPNGRRRLRPNKFRHRHKQTPPTTFAPSETFSTQPTQAPDIKISSQVESSLVPTAWVDNTVNTPKQLEMEKNAEPTSKGTPRRKHGKRPNKHRYTPSTVSSRASGSKPSPSPENKHRNIVTPSSETILLPRTVSLKTEGPYDSLDYMTTTRKIYSSYPKVQETLPVTYKPTSDGKEIKDDVATNVDKHKSDILVTGESITNAIPTSRSLVSTMGEFKEESSPVGFPGTPTWNPSRTAQPGRLQTGIPVTTSGENLTDPPLLKELEDVDFTSEFLSSLTVSTPFHQEEAGSSTTLSSIKVEVASSQAETTTLDQDHLETTVAILLSETRPQNHTPTAARMKEPASSSPSTILMSLGQTTTTKPALPSPRISQASRDSKENVFLNYVGNPETEATPVNNEGTQHMSGPNELSTPSSDQDAFNLSTKLELEKQVFGSRSLPRGPDSQRQDGRVHASHQLTRVPAKPILPTATVRLPEMSTQSASRYFVTSQSPRHWTNKPEITTYPSGALPENKQFTTPRLSSTTIPLPLHMSKPSIPSKFTDRRTDQFNGYSKVFGNNNIPEARNPVGKPPSPRIPHYSNGRLPFFTNKTLSFPQLGVTRRPQIPTSPAPVMRERKVIPGSYNRIHSHSTFHLDFGPPAPPLLHTPQTTGSPSTNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHVF"},{"id":"SEQ_08799","a":"P0CJ86","g":"DUX4L3","d":"Double homeobox protein 4-like protein 3","L":424,"m":[{"c":"GRR+RxφφT[PG]SQ[ST]xφLxxxFE+[ND]xΩPGIAxRExLAxxxGψPExRψQIWFQNxRxR","u":55,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two highly conserved 55-residue globular repeat units in the N-terminal half separated by a 20-residue linker, anchored by identical multi-residue blocks (GRR+R, SQ, FE+, ΩPGIA, RExLA, GψPE, and RψQIWFQNxRxR) and conserved hydrophobic core positions.","i":[[19,73,"GRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSR"],[94,148,"GRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRAR"]]}],"s":"MALPTPSDSTLPAEARGRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQHRRESRPWPGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARHPGQGGRAPAQAGGLCSAAPGGGHPAPSWVAFAHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGVSQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLPGPCAVAQPGPAQAGPQGQGVLAPPTSQGSPWWGWGRGPQVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQEPAPWSALPCGLLLDELLASPEFLQQAQPLLETEAPGELEASEEAASLEAPLSEEEYRALLEEL"},{"id":"SEQ_08813","a":"P27816","g":"MAP4","d":"Microtubule-associated protein 4","L":1152,"m":[{"c":"[DN]xxxxxxx[EDN]φxxx[KNE]","u":14,"sp":"tandem","x":"disordered_like","cf":"high","why":"17-copy 14-aa repeat organized primarily in two head-to-tail tandem arrays (residues 249-346 and 449-574, plus one unit at 409-422), anchored by N-terminal D/N, a conserved acidic/polar+hydrophobic pair ([EDN]φ, predominantly E-V/M) at positions 9-10, and a C-terminal K in 15 of 17 copies.","i":[[249,262,"DMAPSKETEMALAK"],[263,276,"DMALATKTEVALAK"],[277,290,"DMESPTKLDVTLAK"],[291,304,"DMQPSMESDMALVK"],[305,318,"DMELPTEKEVALVK"],[319,332,"DVRWPTETDVSSAK"],[333,346,"NVVLPTETEVAPAK"],[409,422,"DLVLLSEIEVAQAN"],[449,462,"DMTLPPETNVILTK"],[463,476,"DKALPLEAEVAPVK"],[477,490,"DMAQLPETEIAPAK"],[491,504,"DVAPSTVKEVGLLK"],[505,518,"DMSPLSETEMALGK"],[519,532,"DVTPPPETEVVLIK"],[533,546,"NVCLPPEMEVALTE"],[547,560,"DQVPALKTEAPLAK"],[561,574,"DGVLTLANNVTPAK"]]},{"c":"[SA]K[VC]GSxxN[IV][KG]HxP[GA]GGx[VA][KQ]x[EQ]","u":21,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four C-terminal 21-aa repeats separated by variable linkers (48, 10, and 11 aa) with strong multi-position conservation including [SA]K[VC]GS, N[IV][KG]HxP[GA]GG, and C-terminal [VA][KQ]x[EQ].","i":[[937,957,"SKVGSTENIKHQPGGGRAKVE"],[1006,1026,"SKCGSKDNIKHVPGGGNVQIQ"],[1037,1057,"SKCGSKANIKHKPGGGDVKIE"],[1069,1089,"AKVGSLDNVGHLPAGGAVKTE"]]},{"c":"KETERASPIKMDLAPSKDMGPPKENK","u":26,"sp":"tandem","x":"disordered_like","cf":"high","why":"Exact 100%-identical 26-aa head-to-tail tandem duplication (residues 352-403) embedded between the two blocks of 14-aa repeats.","i":[[352,377,"KETERASPIKMDLAPSKDMGPPKENK"],[378,403,"KETERASPIKMDLAPSKDMGPPKENK"]]}],"s":"MADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGSPTEFLEEKMAYQEYPNSQNWPEDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGMSPCNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLELAKEIEMASEERPPAQALEIMMGLKTTDMAPSKETEMALAKDMALATKTEVALAKDMESPTKLDVTLAKDMQPSMESDMALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSELSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEAPLCPGPPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGDQREAQTLDSQIQETSI"},{"id":"SEQ_08825","a":"P32242","g":"OTX1","d":"Homeobox protein OTX1","L":354,"m":[{"c":"LxFNS[AP]DCLDYK-(x){1,7}[SA][SA]W+","u":"18-24","sp":"tandem","x":"mixed","cf":"high","why":"Head-to-tail C-terminal tandem duplication (residues 309-350) with 11 identical anchor residues (L, F, N, S, D, C, L, D, Y, K, W) and conserved flanking charges (- and +), differing in length due to a poly-alanine loop insertion (PGAAAAS vs Q) in the first copy.","i":[[309,332,"LAFNSADCLDYKEPGAAAASSAWK"],[333,350,"LNFNSPDCLDYKDQASWR"]]}],"s":"MMSYLKQPPYGMNGLGLAGPAMDLLHPSVGYPATPRKQRRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQSGSGTKSRPAKKKSSPVRESSGSESSGQFTPPAVSSSASSSSSASSSSANPAAAAAAGLGGNPVAAASSLSTPAASSIWSPASISPGSAPASVSVPEPLAAPSNTSCMQRSVAAGAATAAASYPMSYGQGGSYGQGYPTPSSSYFGGVDCSSYLAPMHSHHHPHQLSPMAPSSMAGHHHHHPHAHHPLSQSSGHHHHHHHHHHQGYGGSGLAFNSADCLDYKEPGAAAASSAWKLNFNSPDCLDYKDQASWRFQVL"},{"id":"SEQ_08846","a":"Q14966","g":"ZNF638","d":"Zinc finger protein 638","L":1978,"m":[{"c":"φψ[LH]ψ[TSD][EN]LP[EN][DK]G(x){10,12}FG[KG][VL]x[DH]x[LV]φψ[PS]x[RH][KN][KE]Aφ[LI][EQ]ψxx[KP][EA][AS]xoxψxxΩ(x){8,9}G(x){7,9}P","u":"72-73","sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed ~72-73 aa globular domain repeats sharing conserved hydrophobic beta/alpha core positions and invariant LPxxxG, FG, central A...Ω, and C-terminal G(x){7,9}P anchors.","i":[[677,749,"VLLITELPEDGCTEEDVRKLFQPFGKVNDVLIVPYRKEAYLEMEFKEAITAIMKYIETTPLTIKGKSVKICVP"],[906,978,"VMLVSNLPNKGYSVEEVYDLAKPFGGLKDILILSSHKKAYIEINRKAAESMVKFYTCFPVLMDGNQLSISMAP"],[1010,1081,"FVHLDNLPEDGLQCVLCVGLQFGKVDHHVFISNRNKAILQLDSPESAQSMYSFLKQNPQNIGDHMLTCSLSP"]]},{"c":"[LF][VF]T[VL]DEψx-","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Eight dispersed copies of a tightly conserved 9-aa motif in the C-terminal acidic disordered region, anchored by an invariant T[VL]DE core, flanking N-terminal hydrophobics ([LF][VF]), position-7 aliphatic (ψ), and C-terminal acidic residue (-) followed by an acidic tract.","i":[[1541,1549,"FVTVDEVIE"],[1598,1606,"FVTLDEIGE"],[1618,1626,"LVTVDEVID"],[1642,1650,"LFTLDELID"],[1680,1688,"LVTVDEIGE"],[1733,1741,"LVTVDEIQD"],[1748,1756,"LVTLDEVTE"],[1774,1782,"FVTVDEVGE"]]}],"s":"MSRPRFNPRGDFPLQRPRAPNPSGMRPPGPFMRPGSMGLPRFYPAGRARGIPHRFAGHESYQNMGPQRMNVQVTQHRTDPRLTKEKLDFHEAQQKKGKPHGSRWDDEPHISASVAVKQSSVTQVTEQSPKVQSRYTKESASSILASFGLSNEDLEELSRYPDEQLTPENMPLILRDIRMRKMGRRLPNLPSQSRNKETLGSEAVSSNVIDYGHASKYGYTEDPLEVRIYDPEIPTDEVENEFQSQQNISASVPNPNVICNSMFPVEDVFRQMDFPGESSNNRSFFSVESGTKMSGLHISGGQSVLEPIKSVNQSINQTVSQTMSQSLIPPSMNQQPFSSELISSVSQQERIPHEPVINSSNVHVGSRGSKKNYQSQADIPIRSPFGIVKASWLPKFSHADAQKMKRLPTPSMMNDYYAASPRIFPHLCSLCNVECSHLKDWIQHQNTSTHIESCRQLRQQYPDWNPEILPSRRNEGNRKENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFISRYRSRSRSRSPYRIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGTEFNKQKHLEAADKGHSPAQKPKTSSGTKPSVKPTSATKSDSNLGGHSIRCKSKNLEDDTLSECKQVSDKAVSLQRKLRKEQSLHYGSVLLITELPEDGCTEEDVRKLFQPFGKVNDVLIVPYRKEAYLEMEFKEAITAIMKYIETTPLTIKGKSVKICVPGKKKAQNKEVKKKTLESKKVSASTLKRDADASKAVEIVTSTSAAKTGQAKASVAKVNKSTGKSASSVKSVVTVAVKGNKASIKTAKSGGKKSLEAKKTGNVKNKDSNKPVTIPENSEIKTSIEVKATENCAKEAISDAALEATENEPLNKETEEMCVMLVSNLPNKGYSVEEVYDLAKPFGGLKDILILSSHKKAYIEINRKAAESMVKFYTCFPVLMDGNQLSISMAPENMNIKDEEAIFITLVKENDPEANIDTIYDRFVHLDNLPEDGLQCVLCVGLQFGKVDHHVFISNRNKAILQLDSPESAQSMYSFLKQNPQNIGDHMLTCSLSPKIDLPEVQIEHDPELEKESPGLKNSPIDESEVQTATDSPSVKPNELEEESTPSIQTETLVQQEEPCEEEAEKATCDSDFAVETLELETQGEEVKEEIPLVASASVSIEQFTENAEECALNQQMFNSDLEKKGAEIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMVEAVAEVEKNETVSEILPSTCIVTLVPGIPTGDEKTVDKKNISEKKGNMDEKEEKEFNTKETRMDLQIGTEKAEKNEGRMDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTSILAVSDVSSSKPSIKAVIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLLKPTSARSGLAESSSKFKPTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQETEARPSIMKRDDSNNKTLAEQNTKNPKSTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVNPSQAKQNPLKGKRKETLKNVPFSELNLKKKKGKTSTPRGVEGELSFVTLDEIGEEEDAAAHLAQALVTVDEVIDEEELNMEEMVKNSNSLFTLDELIDQDDCISHSEPKDVTVLSVAEEQDLLKQERLVTVDEIGEVEELPLNESADITFATLNTKGNEGDTVRDSIGFISSQVPEDPSTLVTVDEIQDDSSDLHLVTLDEVTEEDEDSLADFNNLKEELNFVTVDEVGEEEDGDNDLKVELAQSKNDHPTDKKGNRKKRAVDTKKTKLESLSQVGPVNENVMEEDLKTMIERHLTAKTPTKRVRIGKTLPSEKAVVTEPAKGEEAFQMSEVDEESGLKDSEPERKRKKTEDSSSGKSVASDVPEELDFLVPKAGFFCPICSLFYSGEKAMTNHCKSTRHKQNTEKFMAKQRKEKEQNEAEERSSR"},{"id":"SEQ_08848","a":"Q5T0F9","g":"CC2D1B","d":"Coiled-coil and C2 domain-containing protein 1B","L":858,"m":[{"c":"[AD][AL]LxxRxxxY[RKQ]xA[AG]φ[SQ]A+x[AGS][GQ]-xx[KRQ]A+xxxR[GIV][ALG]Kxφxxxψxxx[RE]xG[RQ][KP]ψ[ND]xxxψPx[PA]","u":57,"sp":"dispersed","x":"structured_like","cf":"high","why":"Four gapless 57-aa repeats dispersed across the central region, anchored by invariant L3, R6, Y10, A13, A17, A26, R31, K34, G46, and P55 alongside conserved basic (+18, +27), acidic (-22), and hydrophobic/aliphatic (φ15, φ36, ψ40, ψ49, ψ54) positions.","i":[[168,224,"ALLEERIHNYREAAASAKEAGEAAKARRCERGLKTLESQLASVRRGRKINEDEIPPP"],[281,337,"ALLSSRQREYKVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAMPPA"],[386,442,"DALQQRLNKYREAGIQARSGGDERKARMHERIAKQYQDAIRAHRAGRKVNFAELPVP"],[538,594,"ALLEARKLQYQRAALQAKRSQDLEQAKAYLRVAKWLEAQIIQARSGRPVDLSKVPSP"]]}],"s":"MMPGPRPRKGPQARGQGVAAAKQMGLFMEFGPEDMLLGMDEAEDDEDLEAELLALTGEAQTTGKKPAPKGQAPLPMAHIEKLAADCMRDVEEEEEEEGLEEDAELLTELQEVLGVDEETEPLDGDEVADPGGSEEENGLEDTEPPVQTAVLTASAPAAQAGASQGLHALLEERIHNYREAAASAKEAGEAAKARRCERGLKTLESQLASVRRGRKINEDEIPPPVALGKRPLAPQEPANRSPETDPPAPPALESDNPSQPETSLPGISAQPVSDLDPDPRALLSSRQREYKVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAMPPAPEDLKPQQASQAPTAPSVIPPAVERVQPVMAPDVPATPVAPTESQTVLDALQQRLNKYREAGIQARSGGDERKARMHERIAKQYQDAIRAHRAGRKVNFAELPVPPGFPPIPGLESTMGVEEDAVAATLAAAEKLASAEDSAPADKDEDEPPGHLQGEPPAQAPVAKKPARPTVPSSQRLPEPRASSSKESPSPSVREQLALLEARKLQYQRAALQAKRSQDLEQAKAYLRVAKWLEAQIIQARSGRPVDLSKVPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQQEKCLLFSKQFMHQGNVAETTRFEKLAQDRKKQLEILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTEMHLIIVRGMNLPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNINRNHRGFKRVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKPTGGKLEVKVRLREPLSGQDVQMVTENWLVLEPRGL"},{"id":"SEQ_08858","a":"P55316","g":"FOXG1","d":"Forkhead box protein G1","L":489,"m":[{"c":"[ALS][STL][VLN]PC[SGE]","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Four non-overlapping 6-aa motifs in the C-terminal disordered tail centered on an invariant PC dipeptide (accounting for all four cysteines outside the structured central domain) with conserved polar/aliphatic N-flanking ([ALS][STL][VLN]) and small/polar/acidic C-flanking ([SGE]) residues.","i":[[386,391,"ASVPCG"],[392,397,"LSVPCS"],[401,406,"SLNPCS"],[449,454,"STLPCE"]]}],"s":"MLDMGDRKEVKMIPKSSFSINSLVPEAVQNDNHHASHGHHNSHHPQHHHHHHHHHHHPPPPAPQPPPPPQQQQPPPPPPPAPQPPQTRGAPAADDDKGPQQLLLPPPPPPPPAAALDGAKADGLGGKGEPGGGPGELAPVGPDEKEKGAGAGGEEKKGAGEGGKDGEGGKEGEKKNGKYEKPPFSYNALIMMAIRQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSSDDVFIGGTTGKLRRRSTTSRAKLAFKRGARLTSTGLTFMDRAGSLYWPMSPFLSLHHPRASSTLSYNGTTSAYPSHPMPYSSVLTQNSLGNNHSFSTANGLSVDRLVNGEIPYATHHLTAAALAASVPCGLSVPCSGTYSLNPCSVNLLAGQTSYFFPHVPHPSMTSQSSTSMSARAASSSTSPQAPSTLPCESLRPSLPSFTTGLSGGLSDYFTHQNQGSSSNPLIH"},{"id":"SEQ_08866","a":"Q6ZN04","g":"MEX3B","d":"RNA-binding protein MEX3B","L":569,"m":[{"c":"V[AG]xψVGxxGxxIKxψxxxTTYIxTPxRxxEPVFxVTGxxE[DN]VxxARxEI","u":50,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 50-residue globular domain repeats (50% sequence identity across 25 fixed positions including VxxGxxGxxIK, TxTYIxTPxR, EPVFxVTG, and ExVxxARxEI) separated by a 47-residue linker.","i":[[78,127,"VAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFVVTGRKEDVAMARREI"],[172,221,"VGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEI"]]}],"s":"MPSSLFADLERNGSGGGGGGSSGGGETLDDQRALQLALDQLSLLGLDSDEGASLYDSEPRKKSVNMTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFVVTGRKEDVAMARREIISAAEHFSMIRASRNKNTALNGAVPGPPNLPGQTTIQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEAHIALRTGGIIELTDENDFHANGTDVGFDLHHGSGGSGPGSLWSKPTPSITPTPGRKPFSSYRNDSSSSLGSASTDSYFGGGTSSSAAATQRLADYSPPSPALSFAHNGNNNNNGNGYTYTAGGEASVPSPDGCPELQPTFDPAPAPPPGAPLIWAQFERSPGGGPAAPVSSSCSSSASSSASSSSVVFPGGGASAPSNANLGLLVHRRLHPGTSCPRLSPPLHMAPGAGEHHLARRVRSDPGGGGLAYAAYANGLGAQLPGLQPSDTSGSSSSSSSSSSSSSSSSGLRRKGSRDCSVCFESEVIAALVPCGHNLFCMECANRICEKSEPECPVCHTAVTQAIRIFS"},{"id":"SEQ_08880","a":"Q8TD55","g":"PLEKHO2","d":"Pleckstrin homology domain-containing family O member 2","L":490,"m":[{"c":"SET(x){10,13}PPxxψLx-KLK[VA]Sφ","u":"27-30","sp":"dispersed","x":"disordered_like","cf":"high","why":"Internal duplication within the central disordered region anchored by an N-terminal SET tripeptide and a strongly conserved C-terminal 14-residue amphipathic motif (PPxxψLx-KLK[VA]Sφ) separated by a 10-13 aa Pro/Glu-rich linker.","i":[[248,274,"SETPAEEDSGSEQPPNSVLPDKLKVSW"],[296,325,"SETSEAAPREGGKPPTPPPKILSEKLKASM"]]}],"s":"MEEEGVKEAGEKPRGAQMVDKAGWIKKSSGGLLGFWKDRYLLLCQAQLLVYENEDDQKCVETVELGSYEKCQDLRALLKRKHRFILLRSPGNKVSDIKFQAPTGEEKESWIKALNEGINRGKNKAFDEVKVDKSCALEHVTRDRVRGGQRRRPPTRVHLKEVASAASDGLLRLDLDVPDSGPPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAEGTPGTPPKDATTSTALPPWDLPPQFHPRCSSLGDLLGEGPRHPLQPRERLYRAQLEVKVASEQTEKLLNKVLGSEPAPVSAETLLSQAVEQLRQATQVLQEMRDLGELSQEAPGLREKRKELVTLYRRSAP"},{"id":"SEQ_08883","a":"Q96AY4","g":"TTC28","d":"Tetratricopeptide repeat protein 28","L":2481,"m":[{"c":"xxxA[YLH]x[NSG][LM]Gxx[YFH]xxψGxΩxxAψxx[HY]xQxLxψAxxψx(x){4,7}","u":"40-43","sp":"tandem","x":"structured_like","cf":"high","why":"Unbroken head-to-tail tandem array of 23 alpha-solenoid-like 40-aa repeats (one copy 43 aa due to a 3-residue C-terminal loop insertion) spanning residues 233-1155, flanked by three divergent N/C-terminal capping copies. Copies share strong multi-position anchors including [NSG][LM]G, an inter-helical ψG turn, ΩxxAψ, and [HY]xQxLxψA.","i":[[233,272,"RGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTG"],[273,312,"ECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREA"],[313,352,"ASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELS"],[353,392,"EARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKRE"],[393,432,"EARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAI"],[433,472,"EMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAA"],[473,512,"EGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAA"],[513,552,"QGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRAS"],[553,592,"QASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQS"],[593,632,"EARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEG"],[633,672,"EGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLS"],[673,712,"QAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQA"],[713,752,"KFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRL"],[753,792,"EASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPG"],[793,832,"ECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSL"],[833,875,"EAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLD"],[876,915,"RGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQD"],[916,955,"QAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFN"],[956,995,"KAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRAL"],[996,1035,"ESDAACGLGGVYQQMGEYDTALQYHQLDLQIAEETNNPTC"],[1036,1075,"QGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAA"],[1076,1115,"KTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRRED"],[1116,1155,"EAKIRHGLGLSLWASGNLEEAQHQLYRASALFETIRHEAQ"]]}],"s":"MEQSPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQLYRASALFETIRHEAQLSTDYKLSLFDLQTSSYQALQRVLVSLGHHDEALAVAERGRTRAFADLLVERQTGQQDSDPYSPVTIDQILEMVNGQRGLVLYYSLAAGYLYSWLLAPGAGIVKFHEHYLGENTVENSSDFQASSSVTLPTATGSALEQHIASVREALGVESHYSRACASSETESEAGDIMDQQFEEMNNKLNSVTDPTGFLRMVRRNNLFNRSCQSMTSLFSNTVSPTQDGTSSLPRRQSSFAKPPLRALYDLLIAPMEGGLMHSSGPVGRHRQLILVLEGELYLIPFALLKGSSSNEYLYERFGLLAVPSIRSLSVQSKSHLRKNPPTYSSSTSMAAVIGNPKLPSAVMDRWLWGPMPSAEEEAYMVSELLGCQPLVGSVATKERVMSALTQAECVHFATHISWKLSALVLTPSMDGNPASSKSSFGHPYTIPESLRVQDDASDGESISDCPPLQELLLTAADVLDLQLPVKLVVLGSSQESNSKVTADGVIALTRAFLAAGAQCVLVSLWPVPVAASKMFIHAFYSSLLNGLKASAALGEAMKVVQSSKAFSHPSNWAGFMLIGSDVKLNSPSSLIGQALTEILQHPERARDALRVLLHLVEKSLQRIQNGQRNAMYTSQQSVENKVGGIPGWQALLTAVGFRLDPPTSGLPAAVFFPTSDPGDRLQQCSSTLQSLLGLPNPALQALCKLITASETGEQLISRAVKNMVGMLHQVLVQLQAGEKEQDLASAPIQVSISVQLWRLPGCHEFLAALGFDLCEVGQEEVILKTGKQANRRTVHFALQSLLSLFDSTELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFSPTGADSIASDAISVYSLSSIASSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRSTLPRSQLPPQTRPAGNKDEEEYEGFSIISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSSKGSISTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLDPQELAQKILEETQSHLIAVERLQRSGGQVSKSNNPEDGVQAPSSTAVFRASETSAFSRPVLSHQKSQPSPVTVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPGCDSQTSQLDQPLFKLKYPSSPYSAHISKSPRNMSPSSGHQSPAGSAPSPALSYSSAGSARSSPADAPDIDKLKMAAIDEKVQAVHNLKMFWQSTPQHSTGPMKIFRGAPGTMTSKRDVLSLLNLSPRHNKKEEGVDKLELKELSLQQHDGAPPKAPPNGHWRTETTSLGSLPLPAGPPATAPARPLRLPSGNGYKFLSPGRFFPSSKC"},{"id":"SEQ_08896","a":"Q9HC35","g":"EML4","d":"Echinoderm microtubule-associated protein-like 4","L":981,"m":[{"c":"(x){8,11}xxx[LVA]xx(x){4,6}xxψxxx(x){4,15}φxx[WLY]x","u":"34-45","sp":"dispersed","x":"structured_like","cf":"high","why":"Ten structured ~34-45 aa beta-propeller-like repeats spanning residues 303-877, anchored by frequent N-terminal [GA]H dipeptides, conserved aliphatic beta-strand cores ([LVA] and ψ), [AT]G/[GS]xD turns, and C-terminal φxx[WLY][DNSTK] (predominantly WD) motifs.","i":[[303,347,"RHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWD"],[355,395,"QIIGLGTFERGVGCLDFSKADSGVHLCIIDDSNEHMLTVWD"],[403,437,"AEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWT"],[450,483,"FGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWS"],[503,537,"KQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWD"],[586,620,"IEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWN"],[628,661,"WTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLD"],[666,703,"DLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYV"],[714,749,"YGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWD"],[828,863,"HKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWK"]]}],"s":"MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGANRKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEKSHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTPTPPPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPCNEISKEQAKATLLEDQQDPSPSS"},{"id":"SEQ_08904","a":"Q6ZQQ2","g":"SPATA31D1","d":"Spermatogenesis-associated protein 31D1","L":1576,"m":[{"c":"[HKM]LExxφ(x){3,7}[FLR]WGLP[SRL]x[HIV]x[EK]S[LIQ]","u":"21-25","sp":"dispersed","x":"mixed","cf":"high","why":"Four dispersed 21-25 aa repeats between residues 495 and 927 sharing an invariant N-terminal LE, an amphipathic 7- or 11-residue helical spacer, an invariant WGLP core, and a C-terminal [EK]S[LIQ] (predominantly ESL/ESI) motif.","i":[[495,515,"HLEQKYVQLFWGLPSLHSESL"],[623,647,"HLEWNVLQKVQESLWGLPSVVQKSQ"],[686,710,"KLEQHIRRRLIQRRWGLPRRIHESL"],[902,926,"MLEAHIKTFRMRMLWGLPLKVLESI"]]},{"c":"DSKDG[VA]SxSxxRxT(x){0,2}FQ[GS]EKLx[ST]TSS[VF]PILxxxxxV[ST]SPVxQExQGTLRR[QE]FSDTD[HN]DL[IT]E[ST]","u":"61-63","sp":"tandem","x":"disordered_like","cf":"high","why":"Head-to-tail tandem 61-63 aa internal duplication (residues 955-1078) with 39 identical positions across its length, including invariant DSKDG, FQ[GS]EKL, TSS[VF]PIL, SPV, QGTLRR, and FSDTD[HN]DL[IT]E[ST] blocks.","i":[[955,1015,"DSKDGVSKSRSRSTFQGEKLGTTSSVPILDRPHPVSSPVVQEGQGTLRRQFSDTDHDLIET"],[1016,1078,"DSKDGASTSLRRGTTDFQSEKLDSTSSFPILGHSYLVTSPVNQEKQGTLRREFSDTDNDLTES"]]},{"c":"S[DS]KDL[RL][ST]NS(x){7,14}xψHL[SE](x){0,2}DSGψRψ[GA]QKQxxxxxTxxLoK","u":"44-49","sp":"dispersed","x":"mixed","cf":"high","why":"Two-copy dispersed 44-49 aa internal duplication (residues 793-836 and 1233-1281) sharing a conserved N-terminal S[DS]KDL[RL][ST]NS motif and a highly conserved C-terminal xψHL[SE](x){0,2}DSGψRψ[GA]QKQxxxxxTxxLoK block (18 identical residues overall).","i":[[793,836,"SDKDLRSNSERDLETHMMHLSGNDSGVRLGQKQLENALTVRLSK"],[1233,1281,"SSKDLLTNSQGISSGDMGTSQVVHVHLEDSGIRVAQKQEPRVPTCVLQK"]]}],"s":"MENILCFLNSYTETGLSPDSHWLDIDPNFICLSGLGLFILYLFYVVLTLYSSPTEKNNDIQKHQGRAKRRRKGGTFKGFPDWKSFQREEEEERKLLSLLKSFGPPVSCSPRGQHHDTNHFRRLLCPDPVCRVCKRATADIQQLLSWESLKDAAPSVSPLASSASATESSFTLASTPSATPPEDLILSPRPKASPPPPLILSPDLITTLADLFSPSPLRDPLPPQPVSPLDSKFPIDHSPPQQLPFPLLPPHHIERVESSLQPEASLSLNTIFSFGSTLCQDISQAMNPIDSCARHHGPPIPSALPPEDCTVTQSKSSLTILKTFPEMLSLGGSGGSSTSAPTIKGIDHSHLASSEFTWWQPHAKDSFSSNFVPSDFMEELLTLHSSEAFLGGHSVANLIEPVNISFLSHDILALLERQVKKRGDFLMWKENGKKPGSFPKQLRPNYQLNSSRNMLTSIAVKHDLAESFPFWASKGKLEWQHIHQQPPHSKCFEDHLEQKYVQLFWGLPSLHSESLHPTVLVQRGHSSMFVFFNGITNTSISHESPVLPPPQPLSLPSTQPLPLPQTLPQGQSPHLTQVKSLAQPQSPFRALLPSPLFLIRICGVCFHRPQNEARSLLPSEINHLEWNVLQKVQESLWGLPSVVQKSQEDFCPPAPNPELVRKSFKVHVPISIIPGDFPLSSEVRKKLEQHIRRRLIQRRWGLPRRIHESLSLLRPQSKISELSVSERIHGPLNISLVEGQRCNVLKKSASSFPRSFHERSSNMLSMENVGNYQGYSQETVPKDHLLHGPETSSDKDLRSNSERDLETHMMHLSGNDSGVRLGQKQLENALTVRLSKKFEEINEGRMPGTVHSSWHSVKQTMSLPEKSHSQIKHRNLVTLVSEDHCVDTSQEISFLSSNKQKMLEAHIKTFRMRMLWGLPLKVLESIEIFKSKADLSTSFSHFDLPSSATFISQGDSKDGVSKSRSRSTFQGEKLGTTSSVPILDRPHPVSSPVVQEGQGTLRRQFSDTDHDLIETDSKDGASTSLRRGTTDFQSEKLDSTSSFPILGHSYLVTSPVNQEKQGTLRREFSDTDNDLTESVRTTEDGRQTFLPPPHSIVDEVSQKQTVLASRCSAELPIMQAGAGCESWDKRKSSFHNVDRLQGSRKTFPVTNALQSQTRNNLTTSKSGSCSLTNVKASTSNETEIFPPRISVPQDPKSSYLKNQMLSQLKLVQRKHSQPQSHFTDMSFALDNLSSKDLLTNSQGISSGDMGTSQVVHVHLEDSGIRVAQKQEPRVPTCVLQKCQVTNFPPAVNRVSPVRPKGGELDGGDAGLGTSQRRRKSLPVHNKTSGEVLGSKSSPTLKTQPPPENLFRKWMKTSLQWFNKPSISYEEQESSWEKGSSLSSCVQNIGRVIRAAFTGTTEAQKIRKDTREFLEEKLGHRHGIDITCPQEPLSFPVGLGKAQHNPEVHVRAEPVQGCPCNYRAPSCKVTRTKSCSQQAIFVGQNYPTRIRQIIDKDRQPQKVEAFKGKILCQSHPQSMPHRKPVPHPNPTCRRQVSLVCPAVPTSAKSPVFSDVPFLTGQKMLPKHLQGGKFPPTK"},{"id":"SEQ_08908","a":"Q04721","g":"NOTCH2","d":"Neurogenic locus notch homolog protein 2","L":2471,"m":[{"c":"[DN]φ[DN][DE]C(x){4,15}PCxNGGxC(x){7,11}CxCPxGΩxGxxC[EQ]","u":"31-47","sp":"tandem","x":"structured_like","cf":"high","why":"Large tandem array of 36 six-cysteine structured repeats (residues 24-1412, separated by 0-2 aa) anchored by an N-terminal acidic [DN]φ[DN][DE]C motif, conserved PCxNGGxC central loop, and C-terminal CxCPxGΩxGxxC signature.","i":[[24,63,"HALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQ"],[64,102,"HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQ"],[105,143,"TSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQ"],[144,180,"WTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCE"],[182,219,"DVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCD"],[221,258,"LYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCE"],[260,296,"NIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCT"],[298,336,"DVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCS"],[338,374,"NIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCH"],[375,413,"LDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCT"],[415,454,"DVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCE"],[456,492,"DINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCE"],[494,530,"EINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQ"],[532,568,"DIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCE"],[570,605,"NIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICS"],[607,643,"QIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCE"],[645,680,"NFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCN"],[682,718,"DIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCY"],[720,755,"QVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCE"],[757,793,"DKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQ"],[795,831,"NIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQ"],[833,871,"VLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCT"],[873,909,"DIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCE"],[911,947,"DIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQ"],[949,985,"DMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCE"],[987,1023,"NINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCL"],[1025,1061,"EINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQ"],[1063,1099,"LVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCD"],[1101,1147,"PNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCE"],[1149,1185,"QLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCE"],[1187,1223,"EVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCE"],[1225,1262,"NIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCE"],[1264,1302,"DINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCE"],[1304,1343,"FVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQ"],[1344,1374,"SSCGQVKCRKGEQCVHTASGPRCFCPSPRDC"],[1375,1412,"ESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCE"]]},{"c":"DxxGx[TS][PA]Lφ[LW]AAx(x){3,19}xxxφxxLψxx[GA]A[DN](x){4,5}","u":"33-49","sp":"tandem","x":"structured_like","cf":"high","why":"Head-to-tail tandem array of 6 structured ~33-aa repeats (with a 16-aa acidic loop insertion in copy 1) defined by conserved DxxG turn residues, a TPLφLAA hydrophobic core, a second amphipathic Lψ-containing segment, and a C-terminal GA[DN] motif.","i":[[1825,1873,"GPDGCTPLMLASLRGGSSDLSDEDEDAEDSSANIITDLVYQGASLQAQT"],[1874,1906,"DRTGEMALHLAARYSRADAAKRLLDAGADANAQ"],[1907,1940,"DNMGRCPLHAAVAADAQGVFQILIRNRVTDLDAR"],[1941,1973,"MNDGTTPLILAARLAVEGMVAELINCQADVNAV"],[1974,2006,"DDHGKSALHWAAAVNNVEATLLLLKNGANRDMQ"],[2007,2039,"DNKEETPLFLAAREGSYEAAKILLDHFANRDIT"]]},{"c":"C(x){3,4}[YP]C[AW]D(x){5,6}CD[EQ]xCN[ST]xxCx[WF]D[GN]x[DE]C","u":"31-32","sp":"dispersed","x":"structured_like","cf":"high","why":"Cluster of 3 distinct six-cysteine repeats (separated by 10-aa and 6-aa linkers at residues 1425-1534) with a C(4-5)C(7-8)C(3)C(4)C(6)C disulfide register and invariant acidic/polar/aromatic anchors ([AW]D, CD[EQ], CN[ST], and [WF]D[GN]x[DE]C).","i":[[1425,1455,"CLSQYCADKARDGVCDEACNSHACQWDGGDC"],[1466,1496,"CSSPLPCWDYINNQCDELCNTVECLFDNFEC"],[1503,1534,"CKYDKYCADHFKDNHCDQGCNSEECGWDGLDC"]]}],"s":"MPALRPALLWALLALWLCCAAPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLFDNFECQGNSKTCKYDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLVIVVLMPPEQLLQDARSFLRALGTLLHTNLRIKRDSQGELMVYPYYGEKSAAMKKQRMTRRSLPGEQEQEVAGSKVFLEIDNRQCVQDSDHCFKNTDAAAALLASHAIQGTLSYPLVSVVSESLTPERTQLLYLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNLSVQVSEANLIGTGTSEHWVDDEGPQPKKVKAEDEALLSEEDDPIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSSDLSDEDEDAEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVICGPNRSFLSLKHTPMGKKSRRPSAKSTMPTSLPNLAKEAKDAKGSRRKKSLSEKVQLSESSVTLSPVDSLESPHTYVSDTTSSPMITSPGILQASPNPMLATAAPPAPVHAQHALSFSNLHEMQPLAHGASTVLPSVSQLLSHHHIVSPGSGSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMVLAPAEGTHPGIAPQSRPPEGKHITTPREPLPPIVTFQLIPKGSIAQPAGAPQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPTAMMPQQDGQVAQTILPAYHPFPASVGKYPTPPSQHSYASSNAAERTPSHSGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGGAGGGQRGPGTHMSEPPHNNMQVYA"},{"id":"SEQ_08920","a":"P0C881","g":"RSPH10B","d":"Radial spoke head 10 homolog B","L":870,"m":[{"c":"YxGxΩxx[GN]xxx[GN]xGxxxΩ(x){5,7}","u":"23-25","sp":"tandem","x":"structured_like","cf":"high","why":"Ten structured 23-25 aa repeats arranged head-to-tail (with a single 10 aa linker between copies 8 and 9) anchored by strictly invariant Y1, G3, and G14 positions alongside conserved [GN]8, [GN]12, and dual aromatic Ω5/Ω18 positions.","i":[[86,108,"YEGEKVRGLYEGEGFAAFQGGCT"],[109,131,"YRGMFSEGLMHGQGTYIWADGLK"],[132,154,"YEGDFVKNVPMNHGVYTWPDGSM"],[155,178,"YEGEVVNGMRNGFGMFKCSTQPVS"],[179,203,"YIGHWCNGKRHGKGSIYYNQEGTCW"],[204,226,"YEGDWVQNIKKGWGIRCYKSGNI"],[227,250,"YEGQWEDNMRHGEGRMRWLTTNEE"],[251,273,"YTGRWERGIQNGFGTHTWFLKRI"],[284,306,"YIGEFVNGYRHGRGKFYYASGAM"],[307,329,"YDGEWVSNKKHGMGRLTFKNGRV"]]},{"c":"MxxxHFφxφLKDxKφ(x){2,3}K[LE][TL][LT]A","u":"22-23","sp":"dispersed","x":"structured_like","cf":"medium","why":"Two-copy internal duplication within the central structured region sharing nine invariant anchor residues (M, H, F, L, K, D, K, K, A) and three conserved hydrophobic positions across 22-23 aa.","i":[[442,464,"MTKLHFWRFLKDCKFHHHKLTLA"],[576,597,"MKMRHFLWMLKDFKMINKELTA"]]}],"s":"MVKEKKKADKKGEKSARSPSSLSDNLDFSKQDGNTTRQEMSPAGVPLLGMQLNEVKPKKDRQNVQQNEDATQYEESILTKLIVESYEGEKVRGLYEGEGFAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDFVKNVPMNHGVYTWPDGSMYEGEVVNGMRNGFGMFKCSTQPVSYIGHWCNGKRHGKGSIYYNQEGTCWYEGDWVQNIKKGWGIRCYKSGNIYEGQWEDNMRHGEGRMRWLTTNEEYTGRWERGIQNGFGTHTWFLKRIRSSQYPLRNEYIGEFVNGYRHGRGKFYYASGAMYDGEWVSNKKHGMGRLTFKNGRVYEGAFSNDHIAGFPDLEVEFISCLDLSSGVAPRLSRSAELIRKLDGSESHSVLGSSIELDLNLLLDMYPETVQPEEKKQVEYAVLRNITELRRIYSFYSSLGCGHSLDNTFLMTKLHFWRFLKDCKFHHHKLTLADMDRILSANNDIPVEEIHSPFTTILLRTFLNYLLHLAYHIYHEEFQKRSPSLFLCFTKLMTENIRPNAFQIKGNLFREQQRTLYSMSYMNKCWEIYLAYCRPSAAPPHEPTMKMRHFLWMLKDFKMINKELTAATFMEVIAEDNRFIYDGIDSNFEPELVFLEFFEALLSFAFICVTDQMTKSYTNVPADDVSGNKHETIYTILNQDAQNKSPSAVMSHESDAAHSDSARSSSSKLELSPDVNKIRKSEPKIKKSVSHERVSKMNFKLTGKGITFFSSESKKYERPKDDREEEFNTWVNNMYVFFVNTLFHAYKREEAIKEKIRADRLRSTAQAQQRKMEDDELEARLNIFILREEEAKRHDYEVDITVLKEPADVSSSHLILDPPKEDVTVSPSSKTITSKKKKK"},{"id":"SEQ_08927","a":"Q3MIW9","g":"MUCL3","d":"Mucin-like protein 3","L":517,"m":[{"c":"[PL]x[EK][PS]TE[NH]x[GE][RNK]T[AT]xx[NT][KEN][TK]xx","u":19,"sp":"tandem","x":"disordered_like","cf":"high","why":"Four 19 aa repeats clustered in a S/T/P/E/K-rich disordered region (linkers of 0, 9, and 1 aa), anchored by invariant T5, E6, and T11 positions plus conserved [PL]1, [EK]3, [PS]4, [NH]7, and [GE]9 motifs.","i":[[282,300,"LAEPTEHGGRTANENNTPS"],[301,319,"PAEPTENRERTANENKKTI"],[329,347,"PEKPTENLGNTTLTTETIK"],[349,367,"PVKSTENPEKTAAVTKTIK"]]}],"s":"MAQPVHSLCSAFGLQCCLLFLLASWGAGATTFQEYQKTGELSTSDHIFPLTPGLVYSIPFDHIVLHSGQRPPELPKSTEIHEQKRHCNTTRHSKPTDKPTGNSKTIDHKSSTDNHEAPPTSEENSSNQGKDPMIRNQRSVDPADSTTTHKESAGKKHITPAPKSKINCRKSTTGKSTVTRKSDKTGRPLEKSMSTLDKTSTSSHKTTTSFHNSGNSQTKQKSTSFPEKITAASKTTYKTTGTPEESEKTEDSRTTVASDKLLTKTTKNIQETISANELTQSLAEPTEHGGRTANENNTPSPAEPTENRERTANENKKTICTKGKNTPVPEKPTENLGNTTLTTETIKAPVKSTENPEKTAAVTKTIKPSVKVTGDKSLTTTSSHLNKTEVTHQVPTGSFTLITSRTKLSSITSEATGNESHPYLNKDGSQKGIHAGQMGENDSFPAWAIVIVVLVAVILLLVFLGLIFLVSYMMRTRRTLTQNTQYNDAEDEGGPNSYPVYLMEQQNLGMGQIPSPR"},{"id":"SEQ_08939","a":"Q7Z5M5","g":"TMC3","d":"Transmembrane channel-like protein 3","L":1100,"m":[{"c":"[HR]AP[HR]ΩYψxxx[CS]-S(x){11,12}HΩK(x){11,16}PRxxR(x){7,8}QPP","u":"55-58","sp":"dispersed","x":"mixed","cf":"high","why":"Strongly conserved 2-copy 55-58 aa C-terminal internal duplication separated by a 30 aa disordered linker, sharing collinear [HR]AP[HR]ΩYψxxx[CS]-S, internal HΩK, basic-proline PRxxR, and C-terminal QPP sub-motifs.","i":[[883,937,"HAPRYYVINECDSYKKKHLNVWPERHFKIDASGDIVELYPRNVRQYASRVPRQPP"],[968,1025,"RAPHFYIGERSESQTRDPEHQGRVHYKSWNEDFEGHLERPAYVPRKPRSRNFQYPQPP"]]}],"s":"MKTSKASQRYRGIRRNASQCYLYQESLLLSNLDDSFSADETGDSNDPEQIFQNIQFQKDLMANIRCRPWTMGQKLRALRQAKNIVLKFEGRLTRTRGYQAAGAELWRKFARLACNFVVIFIPWEMRIKKIESHFGSGVASYFIFLRWLFGINIVLTIMTGAFIVIPELIAGQPFGSTARKTIPKEQVSSAQDLDTVWSLGGYLQYSVLFYGYYGRERKIGRAGYRLPLAYFLVGMAVFAYSFIILLKKMAKNSRTSLASASNENYTFCWRVFCAWDYLIGNPEAAESKTAAIVNSIREAILEEQEKKKSKNLAVTICLRIIANILVLLSLAGSIYLIYFVVDRSQKLEQSKKELTLWEKNEVSVVVSLVTMIAPSAFDLIAALEMYHPRTTLRFQLARVLVLYLGNLYSLIIALLDKVNSMSIEEMATKNNTSHWIDSTTFFATRTAPEEEKWSTSRPGMGLRRNNTWALEETSISAYTMPLIKANKTSLHTQSPQDQCWETYVGQEMLKLSIIDMLFTVASILLIDFFRGLFVRYLSDYWCWDLESKFPEYGEFKIAENVLHLVYNQGMIWMGAFFSPCLPAFNVLKLIGLMYLRSWAVLTCNVPHQQVFRASRSNNFYLAMLLFMLFLCMLPTIFAIVRYKPSLNCGPFSGQEKIYDIVSETIEKDFPVWFGSVVGHISSPVVILPAVLLLFMLIYYLQSIARSLKLSNHQLKMQIQNARSEDKKKVAQMVEARIQTQEESTKKLPNDSDLTSQLSSAHSGTPQNNGNVAHFDSGSSKSGRIETVAQSMPQSPRPGDRAPSSPLPGVPKSRLEHETNRYLHGLCASTSDLHRNRSRTPMTFTTHIEDVHSEPLFRKDFQQINPPHRGPQASTLLAQGPRPHAPRYYVINECDSYKKKHLNVWPERHFKIDASGDIVELYPRNVRQYASRVPRQPPSPQLSEEEEETPSRDWIKRSLPPRSLIDLRRAPHFYIGERSESQTRDPEHQGRVHYKSWNEDFEGHLERPAYVPRKPRSRNFQYPQPPLKPRGKPRFEPSLTESDSVSAASSSDQQNSSADQYLQVTHSQGRFPRSVGQPSRRKAKSGQELTVDLDDLICSDV"},{"id":"SEQ_08945","a":"Q16760","g":"DGKD","d":"Diacylglycerol kinase delta","L":1214,"m":[{"c":"HoWφxxoxxxxxxCoVC(x){13,14}CxφCKφxφHxxCxxxφxoxC","u":"50-51","sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 50-51 aa cysteine/histidine-rich structured repeats separated by a 23 aa linker, sharing an invariant HxW...CxVC-(x)13-14-CxφCKφxφHxxC...C architecture with conserved hydrophobic and polar positions.","i":[[164,213,"HNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNC"],[236,286,"HQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKC"]]}],"s":"MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLCKVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVTEDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEESEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRLVASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSESEEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRDGLPALNTKILYPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRAFESTLKSWEDKQKCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRDMEQELAHAVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQLDPPQKEQLGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKRSRSGKFRLVTKFKKEKNNKNKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKDLGVTKVGHMKRILCGIKELSRSAPAVEA"},{"id":"SEQ_08965","a":"Q9UQR0","g":"SCML2","d":"Sex comb on midleg-like protein 2","L":700,"m":[{"c":"PPψN[DN]FKVGMKLEAxDx+NxxxψCxATψxxψxGxxψ[RH]ψxφDGxxxxxDΩWxxφDSxDIxPφGxCxxxGDψLQPP","u":74,"sp":"dispersed","x":"structured_like","cf":"high","why":"Strongly conserved 74-residue N-terminal globular domain duplication separated by a 35-aa linker, sharing 35 identical anchor positions (including PPψN[DN]FKVGMKLEA, CxAT, DG, DΩW, DSxDIxPφGxC, and GDψLQPP) and conserved hydrophobic beta-strand/core positions.","i":[[58,131,"PPVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPP"],[167,240,"PPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP"]]}],"s":"MGQTVNEDSMDVKKENQEKTPQSSTSSVQRDDFHWEEYLKETGSISAPSECFRQSQIPPVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQMNTSSWPMFLLKTLNGSEMASATLFKKEPPKPPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPGTSVPIVKNIAKTESSPSEASQHSMQSPQKTTLILPTQQVRRSSRIKPPGPTAVPKRSSSVKNITPRKKGPNSGKKEKPLPVICSTSAASLKSLTRDRGMLYKDVASGPCKIVMSTVCVYVNKHGNFGPHLDPKRIQQLPDHFGPGPVNVVLRRIVQACVDCALETKTVFGYLKPDNRGGEVITASFDGETHSIQLPPVNSASFALRFLENFCHSLQCDNLLSSQPFSSSRGHTHSSAEHDKNQSAKEDVTERQSTKRSPQQTVPYVVPLSPKLPKTKEYASEGEPLFAGGSAIPKEENLSEDSKSSSLNSGNYLNPACRNPMYIHTSVSQDFSRSVPGTTSSPLVGDISPKSSPHEVKFQMQRKSEAPSYIAVPDPSVLKQGFSKDPSTWSVDEVIQFMKHTDPQISGPLADLFRQHEIDGKALFLLKSDVMMKYMGLKLGPALKLCYYIEKLKEGKYS"},{"id":"SEQ_08978","a":"Q8NDI1","g":"EHBP1","d":"EH domain-binding protein 1","L":1231,"m":[{"c":"NPFx-[PV]","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five dispersed copies in a proline/polar-enriched disordered region (residues 268-375) sharing an invariant NPF core followed at +2 by an acidic residue (D/E) and at +3 by P (4/5 copies) or V.","i":[[268,273,"NPFDDP"],[279,284,"NPFGDP"],[309,314,"NPFKEV"],[321,326,"NPFDEP"],[370,375,"NPFYEP"]]},{"c":"ExφψψxEφφφLVNK+xALψRxψ","u":22,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two 22-residue internal duplications in the C-terminal helical domain (residues 1112-1196) conserving 9 identical anchors (E.....E...LVNK..AL.R..) and 9 hydrophobic/aliphatic/basic positions without gaps.","i":[[1112,1133,"EEAMMQEWFMLVNKKNALIRRM"],[1175,1196,"EQLLLDELVALVNKRDALVRDL"]]}],"s":"MASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKDPHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMSMKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITEIVNQLNALSSLDEDQDDCIKQANMRSAKSASSSEELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDSFYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETERRVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKPSPIPSPVLGRKPNASQSLLVWCKEVTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIGISRLLEPSDMVLLAIPDKLTVMTYLYQIRAHFSGQELNVVQIEENSSKSTYKVGNYETDTNSSVDQEKFYAELSDLKREPELQQPISGAVDFLSQDDSVFVNDSGVGESESEHQTPDDHLSPSTASPYCRRTKSDTEPQKSQQSSGRTSGSDDPGICSNTDSTQAQVLLGKKRLLKAETLELSDLYVSDKKKDMSPPFICEETDEQKLQTLDIGSNLEKEKLENSRSLECRSDPESPIKKTSLSPTSKLGYSYSRDLDLAKKKHASLRQTESDPDADRTTLNHADHSSKIVQHRLLSRQEELKERARVLLEQARRDAALKAGNKHNTNTATPFCNRQLSDQQDEERRRQLRERARQLIAEARSGVKMSELPSYGEMAAEKLKERSKASGDENDNIEIDTNEEIPEGFVVGGGDELTNLENDLDTPEQNSKLVDLKLKKLLEVQPQVANSPSSAAQKAVTESSEQDMKSGTEDLRTERLQKTTERFRNPVVFSKDSTVRKTQLQSFSQYIENRPEMKRQRSIQEDTKKGNEEKAAITETQRKPSEDEVLNKGFKDTSQYVVGELAALENEQKQIDTRAALVEKRLRYLMDTGRNTEEEEAMMQEWFMLVNKKNALIRRMNQLSLLEKEHDLERRYELLNRELRAMLAIEDWQKTEAQKRREQLLLDELVALVNKRDALVRDLDAQEKQAEEEDEHLERTLEQNKGKMAKKEEKCVLQ"},{"id":"SEQ_08980","a":"A6NL88","g":"SHISA7","d":"Protein shisa-7","L":538,"m":[{"c":"[RL][LRV]xS[QR]EHLL","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed copies within a 50-residue proline/serine-rich disordered C-terminal region share a nearly invariant S[QR]EHLL hexapeptide core preceded by basic/aliphatic [RL][LRV]x residues.","i":[[382,390,"RVMSQEHLL"],[406,414,"RLVSQEHLL"],[421,429,"LRQSREHLL"]]}],"s":"MPALLLLVLLASSAGQARARPSNATSAEPAGPLPALLAHLRRLTGALTGGGGAASPGANGTRTGPAGGAGAAARAPPPAELCHGYYDVMGQYDATFNCSTGSYRFCCGTCHYRFCCEHRHMRLAQASCSNYDTPRWATTPPPLAGGAGGAGGAGGGPGPGQAGWLEGGRTGGAGGRGGEGPGGSTAYVVCGVISFALAVGVGAKVAFSKASRAPRAHRDINVPRALVDILRHQAGPGTRPDRARSSSLTPGIGGPDSMPPRTPKNLYNTVKTPNLDWRALPPPSPSLHYSTLSCSRSFHNLSHLPPSYEAAVKSELNRYSSLKRLAEKDLDEAYLKRRPLELPRGTLPLHALRRPGTGGGYRMEAWGGPEELGLAPAPNPRRVMSQEHLLGDGGRSRYEFTLPRARLVSQEHLLLSSPEALRQSREHLLSPPRSPALPPDPTARASLAASHSNLLLGPGGPPTPLRGLPPPSSLHAHHHHALHGSPQPAWMSDAGGGGGTLARRPPFQRQGTLEQLQFIPGHHLPQHLRTASKNEVTV"},{"id":"SEQ_08984","a":"A7E2V4","g":"ZSWIM8","d":"Zinc finger SWIM domain-containing protein 8","L":1837,"m":[{"c":"[HL][HL]xxA[FY][RE][VI]G[ML]φAL[EG][LM]","u":15,"sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed 15-residue helical motifs (~400 aa apart across structured regions separated by long P/S/G-rich disordered linkers) anchored by invariant A5, G9, A12, and L13 alongside tightly conserved [HL][HL]1-2, [FY]6, [RE]7, [VI]8, [ML]10, φ11, [EG]14, and [LM]15 positions.","i":[[850,864,"HHNLAFRVGMFALEL"],[1277,1291,"LHLCAFEIGLYALGL"],[1663,1677,"HLHAAYRVGMLALEM"]]}],"s":"MELMFAEWEDGERFSFEDSDRFEEDSLCSFISEAESLCQNWRGWRKQSAGPNSPTGGGGGGGSGGTRMRDGLVIPLVELSAKQVAFHIPFEVVEKVYPPVPEQLQLRIAFWSFPENEEDIRLYSCLANGSADEFQRGDQLFRMRAVKDPLQIGFHLSATVVPPQMVPPKGAYNVAVMFDRCRVTSCSCTCGAGAKWCTHVVALCLFRIHNASAVCLRAPVSESLSRLQRDQLQKFAQYLISELPQQILPTAQRLLDELLSSQSTAINTVCGAPDPTAGPSASDQSTWYLDESTLTDNIKKTLHKFCGPSPVVFSDVNSMYLSSTEPPAAAEWACLLRPLRGREPEGVWNLLSIVREMFKRRDSNAAPLLEILTDQCLTYEQITGWWYSVRTSASHSSASGHTGRSNGQSEVAAHACASMCDEMVTLWRLAVLDPALSPQRRRELCTQLRQWQLKVIENVKRGQHKKTLERLFPGFRPAVEACYFNWEEAYPLPGVTYSGTDRKLALCWARALPSRPGASRSGGLEESRDRPRPLPTEPAVRPKEPGTKRKGLGEGVPSSQRGPRRLSAEGGDKALHKMGPGGGKAKALGGAGSGSKGSAGGGSKRRLSSEDSSLEPDLAEMSLDDSSLALGAEASTFGGFPESPPPCPLHGGSRGPSTFLPEPPDTYEEDGGVYFSEGPEPPTASVGPPGLLPGDVCTQDDLPSTDESGNGLPKTKEAAPAVGEEDDDYQAYYLNAQDGAGGEEEKAEGGAGEEHDLFAGLKPLEQESRMEVLFACAEALHAHGYSSEASRLTVELAQDLLANPPDLKVEPPPAKGKKNKVSTSRQTWVATNTLSKAAFLLTVLSERPEHHNLAFRVGMFALELQRPPASTKALEVKLAYQESEVAALLKKIPLGPSEMSTMRCRAEELREGTLCDYRPVLPLMLASFIFDVLCAPGSRPPSRNWNSETPGDEELGFEAAVAALGMKTTVSEAEHPLLCEGTRREKGDLALALMITYKDDQAKLKKILDKLLDRESQTHKPQTLSSFYSSSRPTTASQRSPSKHGGPSAPGALQPLTSGSAGPAQPGSVAGAGPGPTEGFTEKNVPESSPHSPCEGLPSEAALTPRPEGKVPSRLALGSRGGYNGRGWGSPGRPKKKHTGMASIDSSAPETTSDSSPTLSRRPLRGGWAPTSWGRGQDSDSISSSSSDSLGSSSSSGSRRASASGGARAKTVEVGRYKGRRPESHAPHVPNQPSEAAAHFYFELAKTVLIKAGGNSSTSIFTHPSSSGGHQGPHRNLHLCAFEIGLYALGLHNFVSPNWLSRTYSSHVSWITGQAMEIGSAALTILVECWDGHLTPPEVASLADRASRARDSNMVRAAAELALSCLPHAHALNPNEIQRALVQCKEQDNLMLEKACMAVEEAAKGGGVYPEVLFEVAHQWFWLYEQTAGGSSTAREGATSCSASGIRAGGEAGRGMPEGRGGPGTEPVTVAAAAVTAAATVVPVISVGSSLYPGPGLGHGHSPGLHPYTALQPHLPCSPQYLTHPAHPAHPMPHMPRPAVFPVPSSAYPQGVHPAFLGAQYPYSVTPPSLAATAVSFPVPSMAPITVHPYHTEPGLPLPTSVACELWGQGTVSSVHPASTFPAIQGASLPALTTQPSPLVSGGFPPPEEETHSQPVNPHSLHHLHAAYRVGMLALEMLGRRAHNDHPNNFSRSPPYTDDVKWLLGLAAKLGVNYVHQFCVGAAKGVLSPFVLQEIVMETLQRLSPAHAHNHLRAPAFHQLVQRCQQAYMQYIHHRLIHLTPADYDDFVNAIRSARSAFCLTPMGMMQFNDILQNLKRSKQTKELWQRVSLEMATFSP"},{"id":"SEQ_08993","a":"P04280","g":"PRB1","d":"Basic salivary proline-rich protein 1","L":392,"m":[{"c":"GGN[QK]PQGPPPPPGKPQGPP[PQ]QGGN+PQGPPPPGKPQGPP[PA]QG(x){1,2}KS[QR]S[PA][RQ]SPPGKPQGPP[PQ]Q","u":"61-62","sp":"tandem","x":"disordered_like","cf":"high","why":"Five highly conserved (~95% identical) head-to-tail 61-62 aa higher-order tandem repeats in a proline/glycine/glutamine-rich disordered region, each composed of three ~20-21 aa KPQGPPPQ-containing sub-segments with invariant GGN, KPQGPP, and KSRS/KSQS anchor motifs.","i":[[43,103,"GGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQ"],[104,164,"GGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSQSPRSPPGKPQGPPPQ"],[165,225,"GGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSQSPRSPPGKPQGPPPQ"],[226,286,"GGNQPQGPPPPPGKPQGPPQQGGNRPQGPPPPGKPQGPPPQGDKSRSPQSPPGKPQGPPPQ"],[287,348,"GGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPAQGGSKSQSARSPPGKPQGPPQQ"]]}],"s":"MLLILLSVALLALSSAQNLNEDVSQEESPSLIAGNPQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSQSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSQSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPQQGGNRPQGPPPPGKPQGPPPQGDKSRSPQSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPAQGGSKSQSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRPPQ"},{"id":"SEQ_09000","a":"Q15858","g":"SCN9A","d":"Sodium channel protein type 9 subunit alpha","L":1988,"m":[{"c":"ψxxxxφxxφxψxxxψxx[NS]xφx[MA](x){44,47}W[NC][WI][LF]D[FS]ψψψ(x){16,22}[LF]R[TSV]φRφ[LA]Rx[LFG]+(x){5,8}[PEK][GT]ψ[KNR][TMV]ψψx[AI]ψ[IGM]x[SA]ψ[KGP][KAS]ψx[DN]ψxψψ[TLC]φφxφ[SFL]ψΩ[AS]ψφGψo[LN]F(x){56,111}φφφΩψxφψφx[GF][SNL]φφ[LVT]ψN[LM]φ[LI][AG][VL]ψφx[ASN]Ω","u":"232-284","sp":"dispersed","x":"structured_like","cf":"high","why":"Four large dispersed multi-segment hydrophobic repeat domains (~232-284 aa) separated by cytoplasmic linkers, sharing conserved W[NC][WI][LF]D[FS]ψψψ, periodic basic [LF]R[TSV]φRφ[LA]Rx[LFG]+, Ω[AS]ψφGψo[LN]F, and C-terminal N[LM]φ[LI][AG][VL]ψφx[ASN]Ω motifs across variable pore loops.","i":[[122,405,"ILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAY"],[740,971,"IVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSF"],[1189,1460,"VEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNF"],[1511,1763,"LVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENF"]]},{"c":"SxR[GT]SLF","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 7-residue motifs clustered within the polar/basic-rich disordered linker between the first and second structured domains, sharing five invariant residues (S, R, S, L, F) and a constrained [GT] position.","i":[[538,544,"SIRGSLF"],[549,555,"SSRTSLF"],[583,589,"SRRGSLF"]]}],"s":"MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLPFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHRPQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLVDGRSALMLPNGQLLPEVIIDKATSDDSGTTNQIHKKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVWRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKDGDRDDDLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPDKEKYEQDRTEKEDKGKDSKESKK"},{"id":"SEQ_09001","a":"Q01082","g":"SPTBN1","d":"Spectrin beta chain, non-erythrocytic 1","L":2364,"m":[{"c":"xxxxxψxxxΩ(x){18,25}φxx[FY]xxxxxxxxx[WF]ψxxxxxφxxxxxxxxxxxxφxxφx+[HQ]xxφ(x){34,36}","u":"105-114","sp":"tandem","x":"structured_like","cf":"high","why":"Sixteen contiguous head-to-tail ~106-aa three-helix structural repeats (residues 387-2095, preceded by a partial N-terminal helical segment) anchored by conserved aromatic core positions (Ω near pos 10, invariant [FY] around pos 33, and invariant [WF]ψ around pos 43-44) plus an amphipathic third helix with a conserved φxxφx+[HQ]xxφ register.","i":[[387,500,"KLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRIT"],[501,610,"ARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIR"],[611,716,"DRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIR"],[717,821,"ERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVR"],[822,927,"GRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIK"],[928,1034,"AQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAIL"],[1035,1141,"SRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLR"],[1142,1247,"QRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQ"],[1248,1352,"EKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVK"],[1353,1458,"EKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDS"],[1459,1564,"KRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIR"],[1565,1670,"QRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERIS"],[1671,1777,"MRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIA"],[1778,1883,"EWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQ"],[1884,1989,"KRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIK"],[1990,2095,"EKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEE"]]},{"c":"Kx[TA]φxxWxxxxxAxx[SP](x){2,3}IxxφxTxφRDGxφφxxLψxxxx[GP]-xψxxx(x){8,10}xNψxxAφoφφxxxxxxxxxxxxxDI(x){8,10}ψxφψφTφφxxFxx","u":"103-104","sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved ~103-104 aa globular repeats near the N-terminus (residues 57-159 and 176-279, separated by a 16-aa polar linker) sharing co-linear multi-block anchors including Kx[TA]φxxW, IxxφxTxφRDGxφφxxLψ, xNψxxAφoφφ, DI, and C-terminal ψxφψφTφφxxF.","i":[[57,159,"KKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQI"],[176,279,"KDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSK"]]}],"s":"MTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPSAQMEGFLNRKHEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKTAASGIPYHSEVPVSLKEAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKDDEEMNTWIQAISSAISSDKHEVSASTQSTPASSRAQTLPTSVVTITSESSPGKREKDKEKDKEKRFSLFGKKK"},{"id":"SEQ_09002","a":"Q9BXX2","g":"ANKRD30B","d":"Ankyrin repeat domain-containing protein 30B","L":1392,"m":[{"c":"E[SL]Px[KN][DP][GS]x[LF][KE]P[TA]x[GE][RM][KQ]x[ST][LV]PNK[AG][LF]E[LW]K[DN]x[EQ]T[FL]+A","u":34,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Six 34-residue repeats (three in direct head-to-tail tandem at 609-710 and three dispersed) anchored by invariant E1, P3, P11, P20-N21-K22, E25, K27, T31, and A34 across a polar/charged disordered central region.","i":[[524,557,"ELPEKPSAFKPAVEMQKTVPNKAFELKNEQTLRA"],[609,642,"ESPVKDGLLKPTCGRKVSLPNKALELKDRETFKA"],[643,676,"ESPDKDGLLKPTCGRKVSLPNKALELKDRETLKA"],[677,710,"ESPDNDGLLKPTCGRKVSLPNKALELKDRETFKA"],[762,795,"ESPDKDGLLKPTCGMKISLPNKALELKDRETFKA"],[908,941,"ESPEKPSHFEPATEMQNSVPNKGLEWKNKQTLRA"]]},{"c":"xxxxT[AP]L[HML]xAxxxxxxxx[VA]xxLψxxxxxφxφx[DN]","u":33,"sp":"tandem","x":"structured_like","cf":"high","why":"Five contiguous head-to-tail 33-residue structured repeats in the N-terminal region defined by conserved T[AP]LxxA and Lψ/φxφ hydrophobic core positions.","i":[[71,103,"MKKRTALHWACVNGHAEVVTFLVDRKCQLNVLD"],[104,136,"GEGRTPLMKALQCEREACANILIDAGADLNYVD"],[137,169,"VYGNTALHYAVYSENLLMVATLLSYGAVIEVQN"],[170,202,"KASLTPLLLAIQKRSKQTVEFLLTKNANANAFN"],[203,235,"ESKCTALMLAICEGSSEIVGMLLQQNVDVFAED"]]},{"c":"xx[QK][NKT][YDQ][VTE][CY][LI]P[EKD][AS][TM][YH]QK[EDV][IFM][KDE][TI]x(x){1,2}[KE][ILV]E","u":"24-25","sp":"dispersed","x":"disordered_like","cf":"high","why":"Five non-overlapping dispersed 24-25 aa modules immediately upstream of other central repeats, strongly anchored by [CY][LI]Pxx[TM][YH]QK and a C-terminal [KE][ILV]E.","i":[[449,473,"AAQNYTCLPDATYQKDIKTINHKIE"],[500,523,"SAKTQVCIPESMYQKVMEINREVE"],[584,608,"VSQKDVYLPKATHQKEFDTLSGKLE"],[737,761,"LLQNDVCLPKATHQKEFDTLSGKLE"],[883,907,"DTQNYECLPEATYQKEIKTTNGKIE"]]},{"c":"[AD]QMFPSESK[QR][KE]-DEE[NY]SWD[SF][EG]Sx[FLC]E","u":25,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 25-residue disordered modules sharing near-identical QMFPSESK, acidic -DEE, and aromatic SWD anchors.","i":[[474,498,"DQMFPSESKREEDEEYSWDSGSLFE"],[558,582,"AQMFPSESKQKDDEENSWDSESPCE"],[711,735,"AQMFPSESKQKDDEENSWDFESFLE"]]},{"c":"DVSSVE[PS][IT]FSLFG[KT][RP]T[IT]ENSQ[CS]TKVEEDFNL[AT]TK","u":34,"sp":"dispersed","x":"mixed","cf":"high","why":"Two long 34-residue dispersed duplications sharing 28 of 34 identical residues including DVSSVE, FSLFG, ENSQxTKVEEDFNL, and C-terminal TK.","i":[[410,443,"DVSSVEPIFSLFGTRTIENSQCTKVEEDFNLATK"],[797,830,"DVSSVESTFSLFGKPTTENSQSTKVEEDFNLTTK"]]},{"c":"[GRK]TPD[ET]A[AE][PSR]LφE","u":11,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three contiguous head-to-tail 11-residue repeats in the N-terminal linker anchored by invariant TPD, A6, L9, hydrophobic pos 10, and E11.","i":[[279,289,"GTPDEAAPLAE"],[290,300,"RTPDTAESLLE"],[301,311,"KTPDEAARLVE"]]}],"s":"MKRLLAAAGKGVRGPEPPNPFSERVYTEKDYGTIYFGDLGKIHTAASRGQVQKLEKMTVGKKPVNLNKRDMKKRTALHWACVNGHAEVVTFLVDRKCQLNVLDGEGRTPLMKALQCEREACANILIDAGADLNYVDVYGNTALHYAVYSENLLMVATLLSYGAVIEVQNKASLTPLLLAIQKRSKQTVEFLLTKNANANAFNESKCTALMLAICEGSSEIVGMLLQQNVDVFAEDIHGITAERYAAACGVNYIHQQLLEHIRKLPKNPQNTNPEGTSTGTPDEAAPLAERTPDTAESLLEKTPDEAARLVEGTSAKIQCLGKATSGKFEQSTEETPRKILRPTKETSEKFSWPAKERSRKITWEEKETSVKTECVAGVTPNKTEVLEKGTSNMIACPTKETSTKASTNVDVSSVEPIFSLFGTRTIENSQCTKVEEDFNLATKIISKSAAQNYTCLPDATYQKDIKTINHKIEDQMFPSESKREEDEEYSWDSGSLFESSAKTQVCIPESMYQKVMEINREVEELPEKPSAFKPAVEMQKTVPNKAFELKNEQTLRAAQMFPSESKQKDDEENSWDSESPCETVSQKDVYLPKATHQKEFDTLSGKLEESPVKDGLLKPTCGRKVSLPNKALELKDRETFKAESPDKDGLLKPTCGRKVSLPNKALELKDRETLKAESPDNDGLLKPTCGRKVSLPNKALELKDRETFKAAQMFPSESKQKDDEENSWDFESFLETLLQNDVCLPKATHQKEFDTLSGKLEESPDKDGLLKPTCGMKISLPNKALELKDRETFKAEDVSSVESTFSLFGKPTTENSQSTKVEEDFNLTTKEGATKTVTGQQERDIGIIERAPQDQTNKMPTSELGRKEDTKSTSDSEIISVSDTQNYECLPEATYQKEIKTTNGKIEESPEKPSHFEPATEMQNSVPNKGLEWKNKQTLRADSTTLSKILDALPSCERGRELKKDNCEQITAKMEQTKNKFCVLQKELSEAKEIKSQLENQKAKWEQELCSVRLTLNQEEEKRRNVDILKEKIRPEEQLRKKLEVKQQLEQTLRIQDIELKSVTSNLNQVSHTHESENDLFHENCMLKKEIAMLKLEVATLKHQHQVKENKYFEDIKILQEKNAELQMTLKLKQKTVTKRASQYREQLKVLTAENTMLTSKLKEKQDKEILETEIESHHPRLASALQDHDQSVTSRKNQELAFHSAGDAPLQGIMNVDVSNTIYNNEVLHQPLYEAQRKSKSPKINLNYAGDDLRENALVSEHAQRDRCETQCQMKKAEHMYQNEQDNVDKHTEQQESLEQKLFQLESKNRWLRQQLVYAHKKVNKSKVTINIQFPEMKMQRHLNEKNEEVFNYGNHLKERIDQYEKEKAEREVSIKKYKYFSNFLKESGLG"},{"id":"SEQ_09003","a":"Q96DT7","g":"ZBTB10","d":"Zinc finger and BTB domain-containing protein 10","L":871,"m":[{"c":"G[TPA]S[NH]DFKYGL[ILM]P","u":12,"sp":"tandem","x":"disordered_like","cf":"high","why":"Four contiguous head-to-tail 12-residue repeats in a disordered linker with 9 invariant anchor positions (G1, S3, D5-F6-K7-Y8-G9-L10, P12) and conserved aliphatic pos 11.","i":[[654,665,"GTSHDFKYGLMP"],[666,677,"GPSNDFKYGLIP"],[678,689,"GTSNDFKYGLIP"],[690,701,"GASNDFKYGLLP"]]},{"c":"[LFY][KS]CxxC[SGK][KY]ψ[FA](x){7,8}RH[LSG][LS]x[HR]","u":"23-24","sp":"periodic","x":"structured_like","cf":"high","why":"Three C-terminal zinc-finger-like repeats separated by uniform 5-aa linkers, anchored by [LFY]xCxxC, conserved hydrophobics, and an RHxxx[HR] helix motif.","i":[[722,744,"LKCPHCSYVAKYRRTLKRHLLIH"],[750,772,"FSCDICGKLFTRREHVKRHSLVH"],[778,801,"YKCMVCKKIFMLAASVGIRHGSRR"]]},{"c":"[SA]E[MR]NRRTLAFRGGG[GL]","u":15,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Two 15-residue dispersed copies in the N-terminal disordered tail sharing 12 identical positions including the invariant ExNRRTLAFRGGG core.","i":[[4,18,"SEMNRRTLAFRGGGL"],[116,130,"AERNRRTLAFRGGGG"]]}],"s":"MSFSEMNRRTLAFRGGGLVTASGGGSTNNNAGGEASAWPPQPQPRQPPPPAPPALQPPNGRGADEEVELEGLEPQDLEASAGPAAGAAEEAKELLLPQDAGGPTSLGGGAGGPLLAERNRRTLAFRGGGGGGLGNNGSSRGRPETSVWPLRHFNGRGPATVDLELDALEGKELMQDGASLSDSTEDEEEGASLGDGSGAEGGSCSSSRRSGGDGGDEVEGSGVGAGEGETVQHFPLARPKSLMQKLQCSFQTSWLKDFPWLRYSKDTGLMSCGWCQKTPADGGSVDLPPVGHDELSRGTRNYKKTLLLRHHVSTEHKLHEANAQESEIPSEEGYCDFNSRPNENSYCYQLLRQLNEQRKKGILCDVSIVVSGKIFKAHKNILVAGSRFFKTLYCFSNKESPNQNNTTHLDIAAVQGFSVILDFLYSGNLVLTSQNAIEVMTVASYLQMSEVVQTCRNFIKDALNISIKSEAPESVVVDYNNRKPVNRDGLSSSRDQKIASFWATRNLTNLASNVKIENDGCNVDEGQIENYQMNDSSWVQDGSPEMAENESEGQTKVFIWNNMGSQGIQETGKTRRKNQTTKRFIYNIPPNNETNLEDCSVMQPPVAYPEENTLLIKEEPDLDGALLSGPDGDRNVNANLLAEAGTSQDGGDAGTSHDFKYGLMPGPSNDFKYGLIPGTSNDFKYGLIPGASNDFKYGLLPESWPKQETWENGESSLIMNKLKCPHCSYVAKYRRTLKRHLLIHTGVRSFSCDICGKLFTRREHVKRHSLVHKKDKKYKCMVCKKIFMLAASVGIRHGSRRYGVCVDCADKSQPGGQEGVDQGQDTEFPRDEEYEENEVGEADEELVDDGEDQNDPSRWDESGEVCMSLDD"},{"id":"SEQ_09012","a":"Q02818","g":"NUCB1","d":"Nucleobindin-1","L":461,"m":[{"c":"φxxxDx[NQ]oxxxφxxx-[FL]x[AL]xx[QT]","u":22,"sp":"dispersed","x":"structured_like","cf":"medium","why":"Three dispersed 22-aa helix-loop-helix (EF-hand-like) repeats anchored by an invariant Asp (pos 5), conserved polar [NQ]o pair (pos 7-8), flanking hydrophobics (pos 1, 12), and an acidic-[FL]x[AL]xx[QT] C-terminal segment.","i":[[138,159,"FEHLDPQNQHTFEARDLELLIQ"],[249,270,"FILHDINSDGVLDEQELEALFT"],[301,322,"MKNVDTNQDRLVTLEEFLASTQ"]]}],"s":"MPPSGPRGTLLLLPLLLLLLLRAVLAVPLERGAPNKEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKFHPDTDDVPVPAPAGDQKEVDTSEKKLLERLPEVEVPQHL"},{"id":"SEQ_09014","a":"A6NI86","g":"GOLGA6L10","d":"Golgin subfamily A member 6-like protein 10","L":522,"m":[{"c":"QEERL[CHR]E","u":7,"sp":"tandem","x":"mixed","cf":"high","why":"Contiguous head-to-tail tandem array of 18 highly conserved 7-aa repeats with six invariant positions (QEERLxE) and position 6 strictly constrained to C, R, or H.","i":[[197,203,"QEERLRE"],[204,210,"QEERLHE"],[211,217,"QEERLHE"],[218,224,"QEERLCE"],[225,231,"QEERLRE"],[232,238,"QEERLCE"],[239,245,"QEERLRE"],[246,252,"QEERLCE"],[253,259,"QEERLRE"],[260,266,"QEERLCE"],[267,273,"QEERLRE"],[274,280,"QEERLRE"],[281,287,"QEERLCE"],[288,294,"QEERLCE"],[295,301,"QEERLRE"],[302,308,"QEERLCE"],[309,315,"QEERLCE"],[316,322,"QEERLCE"]]},{"c":"LRELER","u":6,"sp":"tandem","x":"mixed","cf":"medium","why":"Three exact head-to-tail tandem copies of the asymmetric 6-aa unit LRELER (distinct LRE and LER halves, non-reducible to a <=4-aa repeat) C-terminal to the central coiled-coil/repeat region.","i":[[384,389,"LRELER"],[390,395,"LRELER"],[396,401,"LRELER"]]},{"c":"[QR]ERLL-EVE[EK]LLEQER","u":16,"sp":"dispersed","x":"mixed","cf":"medium","why":"Internal duplication of a 16-aa segment separated by a 10-aa linker between the two tandem repeat arrays, sharing 13/16 identical residues and a conservative D/E substitution.","i":[[329,344,"QERLLEEVEKLLEQER"],[355,370,"RERLLDEVEELLEQER"]]}],"s":"MWPQPRLPPHPAMSEKTQQGKLAAAKKKLKAYWQRKSPGIPAGANRKKKVNGSSPDTATSGGYHSPGDSATGIYGEGRASSTTLQDLESQYQELAVALDSSSAIISQLTENINSLVRTSKEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLHEQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLREQEERLREQEERLCEQEERLCEQEERLREQEERLCEQEERLCEQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLDEVEELLEQERLRQQDERLWQQETLRELERLRELERLRELERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKELEKSGGAEEPRGSESAAAARPVPGAPVPQGAWMCGQAGWTPQEHPGLSGEAVGTGEAAGGAEEAACHSFRAAENRELNITII"},{"id":"SEQ_09028","a":"Q5T1R4","g":"HIVEP3","d":"Transcription factor HIVEP3","L":2406,"m":[{"c":"YxCxxCxxx[CFY][KA][KT]xxxφx[KA]Hx+(x){1,3}[HC]","u":"23-25","sp":"dispersed","x":"structured_like","cf":"high","why":"Five C2H2/C2HC-type zinc-finger repeats anchored by invariant Y1, C3, C6, H19, basic +21, conserved core [CFY]10 and hydrophobic φ16 positions, and a C-terminal coordinating [HC] separated by a 1-3 residue loop; copies 1-2 and 4-5 form two highly homologous 5-aa-linked pairs duplicated ~1560 residues apart, with copy 3 occurring as an isolated C2HC variant between them.","i":[[192,214,"YICQYCSRPCAKPSVLQKHIRSH"],[220,242,"YPCGPCGFSFKTKSNLYKHRKSH"],[643,666,"YECNICGARYKKRDNYEAHKKYYC"],[1754,1776,"YVCEECGIRCKKPSMLKKHIRTH"],[1782,1806,"YVCKHCHFAFKTKGNLTKHMKSKAH"]]}],"s":"MDPEQSVKGTKKAEGSPRKRLTKGEAIQTSVSSSVPYPGSGTAATQESPAQELLAPQPFPGPSSVLREGSQEKTGQQQKPPKRPPIEASVHISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVAPGLHPQSQLLPSHASIIPPEDLPGVPKVFVPRPSQVSLKPTEEAHKKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGMGGEMYPHGLEMERIPGEEFEEPTEGESTDSEEETSATSGHPAELSPRPKQPLLSSGLYSSGSHSSSHERCSLSQSSTAQSLEDPPPFVEPSSEHPLSHKPEDTHTIKQKLALRLSERKKVIDEQAFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTAMLTATSTQPLLPLSTEDKPSLVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLSRRSSMESPKSSLYREPLSSHSEKTKPEQSLLSLQHPPSTAPPVPLLRSHSMPSAACTISTPHHPFRGSYSFDDHITDSEALSHSSHVFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDTASKPSDEVEPKESELTKKTKKGLKTKGVIYECNICGARYKKRDNYEAHKKYYCSELQIAKPISAGTHTSPEAEKSQIEHEPWSQMMHYKLGTTLELTPLRKRRKEKSLGDEEEPPAFESTKSQFGSPGPSDAARNLPLESTKSPAEPSKSVPSLEGPTGFQPRTPKPGSGSESGKERRTTSKEISVIQHTSSFEKSDSLEQPSGLEGEDKPLAQFPSPPPAPHGRSAHSLQPKLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESNVSLSGSSRSASFERDDHGKAEAPSPSSDMRPKPLGTHMLTVPSHHPHAREMRRSASEQSPNVSHSAHMTETRSKSFDYGSLSLTGPSAPAPVAPPARVAPPERRKCFLVRQASLSRPPESELEVAPKGRQESEEPQPSSSKPSAKSSLSQISSAATSHGGPPGGKGPGQDRPPLGPTVPYTEALQVFHHPVAQTPLHEKPYLPPPVSLFSFQHLVQHEPGQSPEFFSTQAMSSLLSSPYSMPPLPPSLFQAPPLPLQPTVLHPGQLHLPQLMPHPANIPFRQPPSFLPMPYPTSSALSSGFFLPLQSQFALQLPGDVESHLPQIKTSLAPLATGSAGLSPSTEYSSDIRLPPVAPPASSSAPTSAPPLALPACPDTMVSLVVPVRVQTNMPSYGSAMYTTLSQILVTQSQGSSATVALPKFEEPPSKGTTVCGADVHEVGPGPSGLSEEQSRAFPTPYLRVPVTLPERKGTSLSSESILSLEGSSSTAGGSKRVLSPAGSLELTMETQQQKRVKEEEASKADEKLELVKPCSVVLTSTEDGKRPEKSHLGNQGQGRRELEMLSSLSSDPSDTKEIPPLPHPALSHGTAPGSEALKEYPQPSGKPHRRGLTPLSVKKEDSKEQPDLPSLAPPSSLPLSETSSRPAKSQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHADRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSSSRKPRMTEVHLPSLVSPEGQKDLARVEKEEERRGEPEEDAPASQRGEPARIKIFEGGYKSNEEYVYVRGRGRGKYVCEECGIRCKKPSMLKKHIRTHTDVRPYVCKHCHFAFKTKGNLTKHMKSKAHSKKCQETGVLEELEAEEGTSDDLFQDSEGREGSEAVEEHQFSDLEDSDSDSDLDEDEDEDEEESQDELSRPSSEAPPPGPPHALRADSSPILGPQPPDAPASGTEATRGSSVSEAERLTASSCSMSSQSMPGLPWLGPAPLGSVEKDTGSALSYKPVSPRRPWSPSKEAGSRPPLARKHSLTKNDSSPQRCSPAREPQASAPSPPGLHVDPGRGMGALPCGSPRLQLSPLTLCPLGRELAPRAHVLSKLEGTTDPGLPRYSPTRRWSPGQAESPPRSAPPGKWALAGPGSPSAGEHGPGLGLDPRVLFPPAPLPHKLLSRSPETCASPWQKAESRSPSCSPGPAHPLSSRPFSALHDFHGHILARTEENIFSHLPLHSQHLTRAPCPLIPIGGIQMVQARPGAHPTLLPGPTAAWVSGFSGGGSDLTGAREAQERGRWSPTESSSASVSPVAKVSKFTLSSELEGGDYPKERERTGGGPGRPPDWTPHGTGAPAEPTPTHSPCTPPDTLPRPPQGRRAAQSWSPRLESPRAPTNPEPSATPPLDRSSSVGCLAEASARFPARTRNLSGEPRTRQDSPKPSGSGEPRAHPHQPEDRVPPNA"},{"id":"SEQ_09037","a":"Q15599","g":"NHERF2","d":"Na(+)/H(+) exchange regulatory cofactor NHE-RF2","L":337,"m":[{"c":"LRPRLC[RH]Lx+GxQGYGFxLH[GS]-K[GS]RxGQΩIRxV-PGSPAxx[AS][AG]LRAxDRLψEVNGxNVEGxxHxxVVxxIKAxExxxRLLVVDxETDExφ+RxxψTxTEE","u":100,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two ungapped 100-residue structured domain repeats separated by a 40-residue linker, sharing 63% sequence identity including invariant LRPRLC, QGYGFxLH, PGSPA, DRLψEVNGxNVEG, RLLVVDxETDE, and C-terminal TEE motifs.","i":[[7,106,"LRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEE"],[147,246,"LRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEE"]]}],"s":"MAAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGLHLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF"},{"id":"SEQ_09044","a":"P04004","g":"VTN","d":"Vitronectin","L":478,"m":[{"c":"[KRS][LTV][FY]φF[KRS]Gx[KQY][CY][WY](x){10,50}[QY]P[KRQ]xI[ARS]xx[FW](x){9,12}","u":"42-82","sp":"dispersed","x":"structured_like","cf":"high","why":"Four structured ~42-82 aa propeller-blade-like repeats anchored by an N-terminal [FY]φF[KRS]Gx[KQY][CY][WY] strand, an internal [QY]P[KRQ]xI[ARS]xx[FW] turn/strand (preceded by a 40-aa loop insertion in copy 3), and a C-terminal G[IV]PxxVDAAφ[TA] motif in copies 1-3 (with a C-terminal LGCPAPGHL cap in copy 4, separated from copy 3 by a basic disordered linker).","i":[[171,212,"SLFAFRGQYCYELDEKAVRPGYPKLIRDVWGIEGPIDAAFTR"],[218,259,"KTYLFKGSQYWRFEDGVLDPDYPRNISDGFDGIPDNVDAALA"],[270,351,"RVYFFKGKQYWEYQFQHQPSQEECEGSSLSAVFEHFAMMQRDSWEDIFELLFWGRTSAGTRQPQFISRDWHGVPGQVDAAMA"],[435,478,"SVFFFSGDKYYRVNLRTRRVDTVDPPYPRSIAQYWLGCPAPGHL"]]}],"s":"MAPLRPLLILALLAWVALADQESCKGRCTEGFNVDKKCQCDELCSYYQSCCTDYTAECKPQVTRGDVFTMPEDEYTVYDDGEEKNNATVHEQVGGPSLTSDLQAQSKGNPEQTPVLKPEEEAPAPEVGASKPEGIDSRPETLHPGRPQPPAEEELCSGKPFDAFTDLKNGSLFAFRGQYCYELDEKAVRPGYPKLIRDVWGIEGPIDAAFTRINCQGKTYLFKGSQYWRFEDGVLDPDYPRNISDGFDGIPDNVDAALALPAHSYSGRERVYFFKGKQYWEYQFQHQPSQEECEGSSLSAVFEHFAMMQRDSWEDIFELLFWGRTSAGTRQPQFISRDWHGVPGQVDAAMAGRIYISGMAPRPSLAKKQRFRHRNRKGYRSQRGHSRGRNQNSRRPSRATWLSLFSSEESNLGANNYDDYRMDWLVPATCEPIQSVFFFSGDKYYRVNLRTRRVDTVDPPYPRSIAQYWLGCPAPGHL"},{"id":"SEQ_09053","a":"O95503","g":"CBX6","d":"Chromobox protein homolog 6","L":412,"m":[{"c":"R[IV]Ix[KRN]x[KV][KV]","u":8,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 8-aa basic-hydrophobic motifs within the central P/G/K/R-rich linker region (residues 158-210) anchored by an invariant R[IV]I triad and C-terminal [KV][KV] pair, with copies 2 and 3 additionally sharing a conserved N-terminal P+xP[KS]RN prefix.","i":[[158,165,"RIINRKVK"],[173,180,"RIILNLKV"],[207,214,"RVIGKSKK"]]}],"s":"MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQKERERELYGPKKRGPKPKTFLLKARAQAEALRISDVHFSVKPSASASSPKLHSSAAVHRLKKDIRRCHRMSRRPLPRPDPQGGSPGLRPPISPFSETVRIINRKVKPREPKRNRIILNLKVIDKGAGGGGAGQGAGALARPKVPSRNRVIGKSKKFSESVLRTQIRHMKFGAFALYKPPPAPLVAPSPGKAEASAPGPGLLLAAPAAPYDARSSGSSGCPSPTPQSSDPDDTPPKLLPETVSPSAPSWREPEVLDLSLPPESAATSKRAPPEVTAAAGPAPPTAPEPAGASSEPEAGDWRPEMSPCSNVVVTDVTSNLLTVTIKEFCNPEDFEKVAAGVAGAAGGGGSIGASK"},{"id":"SEQ_09058","a":"Q6NSI8","g":"SANBR","d":"SANT and BTB domain regulator of class switch recombination","L":718,"m":[{"c":"[GQ][ES][ST]PV[DEG]","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three closely clustered 6-aa motifs in the N-terminal disordered region (residues 62-105) anchored by an invariant [ST]PV core flanked by N-terminal [GQ][ES] and C-terminal [DEG] positions.","i":[[62,67,"GSSPVD"],[77,82,"GESPVE"],[100,105,"QETPVG"]]}],"s":"MSRGYSENNNFLNNNNQMVLDMILYPLIGIPQTINWETIARLVPGLTPKECAKRFDELKSSGSSPVDNQYNSLMAAGESPVETLATYIKSSLLDIHGEFQETPVGHDAVSKTGRHSIASTRNCSSESENCTTHNGGEMTEESEGPNMVIHVCDEAKNLKEDFTCPRDLLISEMKYFAEYLSMDAQRWEEVDISVHCDVHIFNWLIKYIKRNTKENKDCEMPTLEPGNVISILISSEFLKMDSLVEQCIQYCHKNMNAIVATPCNMNCINANLLTRIADLFSHNEVDDLKDKKDKFKSKLFCKKIERLFDPEYLNPDSRSNAATLYRCCLCKKLLTKETERRIPCIPGKINVDRRGNIVYIHIRDKTWDVHEYLNSLFEELKSWRDVYWRLWGTINWLTCSRCYQAFLCIEFSHCQYHSETVVYPTAASSLNTVGTGIYPCCNQKVLRFDPTQLTKGCKVRDHMVTLRDQGEGGDLPSCPTARMLDDLHKYRDVIVVPFSKDTVSDVGVGLCDEKGIECDVLLEPNTPWGPKTGELNAFLSLKNWTLQLKQQSLFSEEEEYTTGSEVTEDEVGDEEEVSKKQRKKEKPKKFTRQPKKQVSSPCAQRKEKALEKSASRDVSPFVMSMQKNKWDATRSLRFNQDAQREDDQRRMTEITGHLIKMRLGDLDRVKSKEAKEFAGGIYSRLEAQIKASVPVSARQSSSEKNTRSKSRFGQGRPA"},{"id":"SEQ_09071","a":"Q86VQ3","g":"TXNDC2","d":"Thioredoxin domain-containing protein 2","L":553,"m":[{"c":"K[SAT][SPL]xx[ATP][IST][QPH][PS]Kxx[DN][ILS]x","u":15,"sp":"tandem","x":"disordered_like","cf":"high","why":"23 head-to-tail tandem copies of a highly conserved 15-aa disordered repeat anchored by invariant Lys at positions 1 and 10, fixed/near-fixed Pro at positions 9 and 15, and tightly constrained [ATP][IST]Q and [DN][ILS] submotifs (followed by one degenerate boundary remnant at 436-450).","i":[[91,105,"KSSANTSHPKQDDSP"],[106,120,"KSSEETIQPKEGDIP"],[121,135,"KAPEETIQSKKEDLP"],[136,150,"KSSEKAIQPKESNIP"],[151,165,"KSSAKPIQPKLGNIP"],[166,180,"KASVKPSQPKEGDIP"],[181,195,"KAPEETIQSKKEDLP"],[196,210,"KSSEEAIQPKEGDIP"],[211,225,"KSSAKPIQPKLGNIA"],[226,240,"KTSVKPSQPKESDIP"],[241,255,"KSPEETIQPKEGDIP"],[256,270,"KSSAKPIQPKLGNIP"],[271,285,"KASVKPSQPKEGDIS"],[286,300,"KSPEEAIQPKEGDLP"],[301,315,"KSLEEAIQPKEGDIP"],[316,330,"KSPEEAIQPKEGDIP"],[331,345,"KSLEEAIQPKEGDIP"],[346,360,"KSPEETIQPKKGDIP"],[361,375,"KSPEEAIQPKEGDIP"],[376,390,"KSPKQAIQPKEGDIP"],[391,405,"KSLEEAIPPKEIDIP"],[406,420,"KSPEETIQPKEDDSP"],[421,435,"KSLEEATPSKEGDIL"]]}],"s":"MDVDKELGMESVKAGASGKPEMRLGTQEETSEGDANESSLLVLSSNVPLLALEFLEIAQAKEKAFLPMVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFHALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEAVIAELK"},{"id":"SEQ_09079","a":"Q6ZN30","g":"BNC2","d":"Zinc finger protein basonuclin-2","L":1099,"m":[{"c":"φC[NY]φCxKxΩxx[KS][GY][TS]ψ+ψHYxxVHL+[EI][KM]HxC[TK]ψxGCN[MA]φF[SP]SxRSR[ND]RHS[AQ]N[PI]N(x){0,2}LH","u":"55-57","sp":"dispersed","x":"structured_like","cf":"high","why":"Three widely dispersed copies of a strongly conserved 55-57 aa paired Cys2His2 module (~24 invariant positions across the unit), each pairing an N-terminal C-x2-C...HYxxVHL finger directly with a C-terminal C-x4-CGCN...RSR[ND]RHS[AQ]N[PI]N(x){0,2}LH finger.","i":[[442,498,"FCNACGKTFYDKGTLKIHYNAVHLKIKHRCTIEGCNMVFSSLRSRNRHSANPNPRLH"],[834,888,"ICYVCKKSFKSSYSVKLHYRNVHLKEMHVCTVAGCNAAFPSRRSRDRHSANINLH"],[1036,1090,"MCNICHKMYSNKGTLRVHYKTVHLREMHKCKVPGCNMMFSSVRSRNRHSQNPNLH"]]}],"s":"MAHLGPTPPPHSLNYKSEDRLSEQDWPAYFKVPCCGVDTSQIESEEAEVDVRERETQRDREPKRARDLTLRDSCTDNSMQFGTRTTTAEPGFMGTWQNADTNLLFRMSQQAIRCTLVNCTCECFQPGKINLRTCDQCKHGWVAHALDKLSTQHLYHPTQVEIVQSNVVFDISSLMLYGTQAVPVRLKILLDRLFSVLKQEEVLHILHGLGWTLRDYVRGYILQDAAGKVLDRWAIMSREEEIITLQQFLRFGETKSIVELMAIQEKEGQAVAVPSSKTDSDIRTFIESNNRTRSPSLLAHLENSNPSSIHHFENIPNSLAFLLPFQYINPVSAPLLGLPPNGLLLEQPGLRLREPSLSTQNEYNESSESEVSPTPYKNDQTPNRNALTSITNVEPKTEPACVSPIQNSAPVSDLTKTEHPKSSFRIHRMRRMGSASRKGRVFCNACGKTFYDKGTLKIHYNAVHLKIKHRCTIEGCNMVFSSLRSRNRHSANPNPRLHMPMLRNNRDKDLIRATSGAATPVIASTKSNLALTSPGRPPMGFTTPPLDPVLQNPLPSQLVFSGLKTVQPVPPFYRSLLTPGEMVSPPTSLPTSPIIPTSGTIEQHPPPPSEPVVPAVMMATHEPSADLAPKKKPRKSSMPVKIEKEIIDTADEFDDEDDDPNDGGAVVNDMSHDNHCHSQEEMSPGMSVKDFSKHNRTRCISRTEIRRADSMTSEDQEPERDYENESESSEPKLGEESMEGDEHIHSEVSEKVLMNSERPDENHSEPSHQDVIKVKEEFTDPTYDMFYMSQYGLYNGGGASMAALHESFTSSLNYGSPQKFSPEGDLCSSPDPKICYVCKKSFKSSYSVKLHYRNVHLKEMHVCTVAGCNAAFPSRRSRDRHSANINLHRKLLTKELDDMGLDSSQPSLSKDLRDEFLVKIYGAQHPMGLDVREDASSPAGTEDSHLNGYGRGMAEDYMVLDLSTTSSLQSSSSIHSSRESDAGSDEGILLDDIDGASDSGESAHKAEAPALPGSLGAEVSGSLMFSSLSGSNGGIMCNICHKMYSNKGTLRVHYKTVHLREMHKCKVPGCNMMFSSVRSRNRHSQNPNLHKNIPFTSVD"},{"id":"SEQ_09093","a":"Q13029","g":"PRDM2","d":"PR domain zinc finger protein 2","L":1718,"m":[{"c":"[FHI]xCxxCxxx[FV]xxxxxxxxH(x){3,4}[HC]","u":"23-24","sp":"dispersed","x":"structured_like","cf":"high","why":"Eight dispersed 23-24 aa zinc-finger-like repeats anchored by invariant CxxC and H-(x){3,4}-[HC] coordination pairs, a conserved [FHI] N-terminal position, a conserved [FV] core residue (7/8 F), and strong aliphatic enrichment (7/8 L/M) three residues before the first coordinating H.","i":[[360,382,"FPCQHCERKFTTKQGLERHMHIH"],[390,412,"FKCKYCGKAFGTQINRRRHERRH"],[483,506,"HPCKYCKKVFGTHTNMRRHQRRVH"],[1134,1156,"FVCNVCESPFLSIKDLTKHLSIH"],[1162,1185,"FKCEFCVQLFKDKTDLSEHRFLLH"],[1191,1214,"FVCSVCKKEFAFLCNLQQHQRDLH"],[1333,1355,"IRCTKCGKGVDNMPELHKHILAC"],[1455,1478,"HICPYCNREFTYIGSLNKHAAFSC"]]}],"s":"MNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGKKKSQENKNKGNKIQDIQLKTSEPDFTSANMRDSAEGPKEDEEKPSASALEQPATLQEVASQEVPPELATPAPAWEPQPEPDERLEAAACEVNDLGEEEEEEEEEDEEEEEDDDDDELEDEGEEEASMPNENSVKEPEIRCDEKPEDLLEEPKTTSEETLEDCSEVTPAMQIPRTKEEANGDVFETFMFPCQHCERKFTTKQGLERHMHIHISTVNHAFKCKYCGKAFGTQINRRRHERRHEAGLKRKPSQTLQPSEDLADGKASGENVASKDDSSPPSLGPDCLIMNSEKASQDTINSSVVEENGEVKELHPCKYCKKVFGTHTNMRRHQRRVHERHLIPKGVRRKGGLEEPQPPAEQAQATQNVYVPSTEPEEEGEADDVYIMDISSNISENLNYYIDGKIQTNNNTSNCDVIEMESASADLYGINCLLTPVTVEITQNIKTTQVPVTEDLPKEPLGSTNSEAKKRRTASPPALPKIKAETDSDPMVPSCSLSLPLSISTTEAVSFHKEKSVYLSSKLKQLLQTQDKLTPAGISATEIAKLGPVCVSAPASMLPVTSSRFKRRTSSPPSSPQHSPALRDFGKPSDGKAAWTDAGLTSKKSKLESHSDSPAWSLSGRDERETVSPPCFDEYKMSKEWTASSAFSSVCNQQPLDLSSGVKQKAEGTGKTPVQWESVLDLSVHKKHCSDSEGKEFKESHSVQPTCSAVKKRKPTTCMLQKVLLNEYNGIDLPVENPADGTRSPSPCKSLEAQPDPDLGPGSGFPAPTVESTPDVCPSSPALQTPSLSSGQLPPLLIPTDPSSPPPCPPVLTVATPPPPLLPTVPLPAPSSSASPHPCPSPLSNATAQSPLPILSPTVSPSPSPIPPVEPLMSAASPGPPTLSSSSSSSSSSSSFSSSSSSSSPSPPPLSAISSVVSSGDNLEASLPMISFKQEELENEGLKPREEPQSAAEQDVVVQETFNKNFVCNVCESPFLSIKDLTKHLSIHAEEWPFKCEFCVQLFKDKTDLSEHRFLLHGVGNIFVCSVCKKEFAFLCNLQQHQRDLHPDKVCTHHEFESGTLRPQNFTDPSKAHVEHMQSLPEDPLETSKEEEELNDSSEELYTTIKIMASGIKTKDPDVRLGLNQHYPSFKPPPFQYHHRNPMGIGVTATNFTTHNIPQTFTTAIRCTKCGKGVDNMPELHKHILACASASDKKRYTPKKNPVPLKQTVQPKNGVVVLDNSGKNAFRRMGQPKRLNFSVELSKMSSNKLKLNALKKKNQLVQKAILQKNKSAKQKADLKNACESSSHICPYCNREFTYIGSLNKHAAFSCPKKPLSPPKKKVSHSSKKGGHSSPASSDKNSNSNHRRRTADAEIKMQSMQTPLGKTRARSSGPTQVPLPSSSFRSKQNVKFAASVKSKKPSSSSLRNSSPIRMAKITHVEGKKPKAVAKNHSAQLSSKTSRSLHVRVQKSKAVLQSKSTLASKKRTDRFNIKSRERSGGPVTRSLQLAAAADLSENKREDGSAKQELKDFSYSLRLASRCSPPAAPYITRQYRKVKAPAAAQFQGPFFKE"},{"id":"SEQ_09095","a":"P06729","g":"CD2","d":"T-cell surface antigen CD2","L":351,"m":[{"c":"[QS][HK]xPP[PL]P[GR][HP]R[SV]Q","u":12,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three 12-residue proline-rich motif copies in the C-terminal disordered tail anchored by N-terminal [QS][HK], a conserved PP[PL]P core, and C-terminal [GR][HP]R[SV]Q separated by 2- and 17-residue linkers.","i":[[280,291,"QHPPPPPGHRSQ"],[294,305,"SHRPPPPGHRVQ"],[323,334,"QKGPPLPRPRVQ"]]}],"s":"MSFPCKFVASFLLIFNVSSKGAVSKEITNALETWGALGQDINLDIPSFQMSDDIDDIKWEKTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCINTTLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESSVEPVSCPEKGLDIYLIIGICGGGSLLMVFVALLVFYITKRKKQRSRRNDEELETRAHRVATEERGRKPHQIPASTPQNPATSQHPPPPPGHRSQAPSHRPPPPGHRVQHQPQKRPPAPSGTQVHQQKGPPLPRPRVQPKPPHGAAENSLSPSSN"},{"id":"SEQ_09098","a":"P16150","g":"SPN","d":"Leukosialin","L":400,"m":[{"c":"T[MIT][AT][AT]xS[LP]E[TP]Sx[GR][AT][ST]G[PA][PQ][VL]","u":18,"sp":"tandem","x":"disordered_like","cf":"high","why":"Five contiguous head-to-tail 18-residue repeats in a Ser/Thr/Pro-rich disordered region featuring invariant T1, S6, E8, S10, and G15 anchors along with conserved S[LP]E[TP]S and G[PA][PQ][VL] submotifs.","i":[[134,151,"TITTNSPETSSRTSGAPV"],[152,169,"TTAASSLETSRGTSGPPL"],[170,187,"TMATVSLETSKGTSGPPV"],[188,205,"TMATDSLETSTGTTGPPV"],[206,223,"TMTTGSLEPSSGASGPQV"]]}],"s":"MATLLLLLGVLVVSPDALGSTTAVQTPTSGEPLVSTSEPLSSKMYTTSITSDPKADSTGDQTSALPPSTSINEGSPLWTSIGASTGSPLPEPTTYQEVSIKMSSVPQETPHATSHPAVPITANSLGSHTVTGGTITTNSPETSSRTSGAPVTTAASSLETSRGTSGPPLTMATVSLETSKGTSGPPVTMATDSLETSTGTTGPPVTMTTGSLEPSSGASGPQVSSVKLSTMMSPTTSTNASTVPFRNPDENSRGMLPVAVLVALLAVIVLVALLLLWRRRQKRRTGALVLSRGGKRNGVVDAWAGPAQVPEEGAVTVTVGGSGGDKGSGFPDGEGSSRRPTLTTFFGRRKSRQGSLAMEELKSGSGPSLKGEEEPLVASEDGAVDAPAPDEPEGGDGAAP"},{"id":"SEQ_09106","a":"Q9NZ81","g":"PRR13","d":"Proline-rich protein 13","L":148,"m":[{"c":"NP[AP][FH]PP","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three 6-residue repeats in the proline-rich disordered region share fixed N1 and P2/P5/P6 positions anchored by an internal aromatic/ring residue ([FH]4) and constrained [AP]3, separated by 3- and 11-residue linkers.","i":[[25,30,"NPAHPP"],[33,38,"NPPFPP"],[51,56,"NPAFPP"]]}],"s":"MWNPNAGQPGPNPYPPNIGCPGGSNPAHPPPINPPFPPGPCPPPPGAPHGNPAFPPGGPPHPVPQPGYPGCQPLGPYPPPYPPPAPGIPPVNPLAPGMVGPAVIVDKKMQKKMKKAHKKMHKHQKHHKYHKHGKHSSSSSSSSSSDSD"},{"id":"SEQ_09121","a":"Q8WXH2","g":"JPH3","d":"Junctophilin-3","L":748,"m":[{"c":"YxGxWxx[GDN](x){3,4}φGψx(x){2,5}G(x){1,3}","u":"22-24","sp":"tandem","x":"structured_like","cf":"high","why":"Eight 22-24 aa structured repeat units arranged in two head-to-tail tandem blocks (6 N-terminal copies at residues 15-152 and 2 internal copies at residues 289-334), anchored by invariant Y (pos 1), G (pos 3), and W (pos 5), a conserved [GDN] turn, a central φGψ motif, and a C-terminal glycine-containing turn.","i":[[15,38,"YCGGWEDGKAHGHGVCTGPKGQGE"],[39,60,"YTGSWSHGFEVLGVYTWPSGNT"],[61,82,"YQGTWAQGKRHGIGLESKGKWV"],[83,106,"YKGEWTHGFKGRYGVRECAGNGAK"],[107,129,"YEGTWSNGLQDGYGTETYSDGGT"],[130,152,"YQGQWVGGMRQGYGVRQSVPYGM"],[288,310,"YVGEWKNDKRSGFGVSQRSDGLK"],[311,333,"YEGEWASNRRHGYGCMTFPDGTK"]]}],"s":"MSSGGRFNFDDGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWSHGFEVLGVYTWPSGNTYQGTWAQGKRHGIGLESKGKWVYKGEWTHGFKGRYGVRECAGNGAKYEGTWSNGLQDGYGTETYSDGGTYQGQWVGGMRQGYGVRQSVPYGMAAVIRSPLRTSINSLRSEHTNGTALHPDASPAVAGSPAVSRGGFVLVAHSDSEILKSKKKGLFRRSLLSGLKLRKSESKSSLASQRSKQSSFRSEAGMSTVSSTASDIHSTISLGEAEAELAVIEDDIDATTTETYVGEWKNDKRSGFGVSQRSDGLKYEGEWASNRRHGYGCMTFPDGTKEEGKYKQNILVGGKRKNLIPLRASKIREKVDRAVEAAERAATIAKQKAEIAASRTSHSRAKAEAALTAAQKAQEEARIARITAKEFSPSFQHRENGLEYQRPKRQTSCDDIEVLSTGTPLQQESPELYRKGTTPSDLTPDDSPLQSFPTSPAATPPPAPAARNKVAHFSRQVSVDEERGGDIQMLLEGRAGDCARSSWGEEQAGGSRGVRSGALRGGLLVDDFRTRGSGRKQPGNPKPRERRTESPPVFTWTSHHRASNHSPGGSRLLELQEEKLSNYRMEMKPLLRMETHPQKRRYSKGGACRGLGDDHRPEDRGFGVQRLRSKAQNKENFRPASSAEPAVQKLASLRLGGAEPRLLRWDLTFSPPQKSLPVALESDEENGDELKSSTGSAPILVVMVILLNIGVAILFINFFI"},{"id":"SEQ_09125","a":"O75923","g":"DYSF","d":"Dysferlin","L":2080,"m":[{"c":"ψxxxxφxxxxxx(x){5,22}[DP]xφxxxxxxx(x){13,22}[WF](x){17,37}φxψxD(x){16,21}ψ","u":"84-117","sp":"dispersed","x":"structured_like","cf":"high","why":"Seven dispersed copies of an 84-117 aa structured beta-rich domain distributed across the full protein length, anchored by a conserved N-terminal hydrophobic strand (ψxxxxφ), a [DP]xφ motif (typically DPY/DPF), an internal [WF] aromatic turn, an invariant aspartate in a φxψxD strand, and a C-terminal aliphatic residue.","i":[[2,88,"LRVFILYAENVHTPDTDISDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLDQGSELHVVVKDHETMGRNRFLGEAKVPL"],[222,305,"IRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFFNLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDV"],[383,485,"LKVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKI"],[1154,1249,"LRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSL"],[1334,1429,"IEILAWGLRNMKSYQLANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLESFL"],[1579,1671,"LVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLL"],[1813,1929,"LRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDL"]]},{"c":"G[KH]LSφφxE[TV]ΩEN[EQ]T+L(x){2,3}G[NQ]W(x){7,10}[ST]DV[TN]Gx[IK][KV]LPKDxφxxxφGW[TK]W(x){2,3}-W","u":"55-58","sp":"dispersed","x":"structured_like","cf":"high","why":"Strongly conserved 55-58 aa two-copy internal duplication separated by a 14-aa linker in the central region, sharing an N-terminal G[KH]LSφφxE[TV]ΩEN[EQ]T+L segment, internal G[NQ]W and [ST]DV[TN]G motifs, and a C-terminal LPKDxφxxxφGW[TK]W...W signature.","i":[[873,930,"GKLSVFAETYENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAGDW"],[945,999,"GHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEW"]]},{"c":"-[EG][QE]GWEY[SA](x){17,22}RRRRW(x){0,3}RRR","u":"33-41","sp":"dispersed","x":"mixed","cf":"medium","why":"Two closely spaced 33-41 aa copies immediately C-terminal to the 55-58 aa duplication, each pairing a conserved N-terminal acidic-aromatic -[EG][QE]GWEY[SA] motif with a C-terminal tryptophan-embedded poly-arginine RRRRW(x){0,3}RRR cluster across a 17-22 aa linker.","i":[[1008,1048,"DEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRR"],[1065,1097,"EGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRR"]]}],"s":"MLRVFILYAENVHTPDTDISDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLDQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVLQVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPTSRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFFNLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEEEPAGAVKPSKASDLDDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETYENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDMDAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQAEAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVMDDKSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLESFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDRVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLVKPFS"},{"id":"SEQ_09132","a":"O94875","g":"SORBS2","d":"Sorbin and SH3 domain-containing protein 2","L":1100,"m":[{"c":"AxY[DN][FY]x[AP]x[TN]xxEL[SE][FL]+[KE][GS]Dx[VI]xψ[LM]x+xD[QD][NG]W[YF][EV]G(x){6,8}G[IT]FP[IVG][SN]YV[EK]x[LV]","u":"51-53","sp":"dispersed","x":"structured_like","cf":"high","why":"Three strongly conserved 51-53 aa globular repeat domains in the C-terminal region separated by 24-aa and 50-aa linkers, anchored by invariant A-x-Y-[DN]-[FY], E-L, D, D-[QD]-[NG]-W-[YF]-[EV]-G, and C-terminal G-[IT]-F-P-x-[SN]-Y-V motifs across a minor 6-8 aa loop.","i":[[870,920,"AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL"],[945,997,"AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV"],[1048,1100,"ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL"]]}],"s":"MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGWQMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESCPMAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRILQYESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEPPQNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDSDQDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCKGRCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQTEKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL"},{"id":"SEQ_09135","a":"Q8NET4","g":"RTL9","d":"Retrotransposon Gag-like protein 9","L":1388,"m":[{"c":"[GE]xψ[SP]xP[LQ]MxA[PTS][AD]S","u":13,"sp":"tandem","x":"disordered_like","cf":"high","why":"Extensive head-to-tail tandem array of 75 canonical 13-aa disordered repeats (spanning residues 72-1088 with occasional minor length-variant copies) defined by a conserved [GE]-x-ψ-[SP]-x-P-[LQ]-M-x-A-[PTS]-[AD]-S architecture.","i":[[72,84,"DTMSAPLMGVPNS"],[85,97,"GALSPPLMPASDS"],[98,110,"GALSPLLMPASDS"],[111,123,"GALSPLLMPALDS"],[136,148,"GVMSPGMMTIPDF"],[149,161,"GTMSATLMVAPDS"],[162,174,"AEISPLAMPAPSS"],[175,187,"GVVCTPIMSTSSS"],[188,200,"EAMSTPLMLAPDS"],[201,213,"GELSPILMQDMNP"],[214,226,"GVMSTQPVPAPSS"],[227,239,"EAMSPLQITDEDT"],[240,252,"EAMSKVLMTALAS"],[253,265,"GEISSLLMSGTDS"],[266,278,"EAISSLIMSAVAS"],[279,291,"GGTSPQPTSTQNS"],[292,304,"GGIPTPLMSDLDS"],[305,317,"GIMSSLLMSSPGS"],[318,330,"EVMSTPLLSVPDA"],[331,343,"GEMSTLPKPAPDA"],[344,356,"EAMSPALMTALPS"],[357,369,"GVMPTQTMPAPGS"],[370,382,"GAMSPWSTQNVDS"],[383,395,"EMMSNPPVRATAS"],[396,408,"GVMSAPPVRALDS"],[409,421,"GAMSTPLMGAPAS"],[422,434,"GNMSTLQKTVPAS"],[435,447,"GAMTTSLMTVPSS"],[448,460,"GVMSTEQMSATAS"],[461,473,"RVMSAQLTMAKTS"],[495,507,"GKMSTPLRRAPTS"],[508,520,"GAMSTQPVTATAS"],[521,533,"ETMSMPQLTVPAS"],[534,546,"GSMSMLQMRAPVS"],[547,559,"EAMSMPQMRTMAS"],[560,572,"GLTSAAQMKAMTS"],[573,585,"GAMSTPLMTAQTS"],[586,598,"GSTSTLLMRDTAS"],[599,611,"GVMSCPQMRSLAS"],[612,624,"GALSKPLMTPKAS"],[625,637,"GTMFTEKMTTTAS"],[638,650,"EAMPTLLMRDTVS"],[651,663,"GALSMPQMTDTAS"],[664,676,"GGLSASLMRDTAS"],[677,689,"GAMSTSQMTATVS"],[690,702,"GGMSMPLMRAQDP"],[703,715,"GVMPASLMRAKVS"],[716,728,"GKMLSQPMSTQDP"],[729,741,"GGMSMSPMKSMTA"],[752,764,"DVMSTPTVRAWTS"],[765,777,"ETMSTPLMRTSDP"],[778,790,"GERPSLLTRASSS"],[791,803,"GEMSLPLMRAPAS"],[816,828,"GAMSAPQMTATAS"],[843,855,"GAMSMPLTRSTAS"],[856,868,"GGMSMPLMRAPDS"],[869,881,"RVTSTSQMMPTAS"],[882,894,"GDMCTLPVRAPAS"],[895,907,"GGVSSPLVRAPAS"],[908,920,"GTMSTPLRRPSAC"],[921,933,"ETVSTELMRASAS"],[934,946,"GHMSTAQTTAMVS"],[947,959,"GGMSKPLMRAPAS"],[960,972,"GTMPMPLMSAMAS"],[973,985,"GEMSMPLMETMAS"],[986,998,"GATSTLQTSVANS"],[999,1011,"RSMSLSQTTYTVS"],[1012,1024,"GRMATAPIRASAS"],[1025,1037,"GARSTSFMRASVS"],[1038,1050,"GSMPMPLPRATAS"],[1054,1066,"MGMSMPQMTATDS"],[1067,1079,"RGMSTPLMRASGP"],[1090,1102,"GVMSTPEIKATDS"],[1103,1115,"GEASTSHINITAS"],[1116,1128,"GSKPTSHMTATTP"]]}],"s":"MSIPLHSLRFNNTMREENVEPQNKQMAFCRPMTETRADVQILHSHVQLPIVSTSASDPGGTSTQLMTSPVFDTMSAPLMGVPNSGALSPPLMPASDSGALSPLLMPASDSGALSPLLMPALDSGTLSPLLSTSEYGVMSPGMMTIPDFGTMSATLMVAPDSAEISPLAMPAPSSGVVCTPIMSTSSSEAMSTPLMLAPDSGELSPILMQDMNPGVMSTQPVPAPSSEAMSPLQITDEDTEAMSKVLMTALASGEISSLLMSGTDSEAISSLIMSAVASGGTSPQPTSTQNSGGIPTPLMSDLDSGIMSSLLMSSPGSEVMSTPLLSVPDAGEMSTLPKPAPDAEAMSPALMTALPSGVMPTQTMPAPGSGAMSPWSTQNVDSEMMSNPPVRATASGVMSAPPVRALDSGAMSTPLMGAPASGNMSTLQKTVPASGAMTTSLMTVPSSGVMSTEQMSATASRVMSAQLTMAKTSGAMPTGSMKAVAKQYKRATASGKMSTPLRRAPTSGAMSTQPVTATASETMSMPQLTVPASGSMSMLQMRAPVSEAMSMPQMRTMASGLTSAAQMKAMTSGAMSTPLMTAQTSGSTSTLLMRDTASGVMSCPQMRSLASGALSKPLMTPKASGTMFTEKMTTTASEAMPTLLMRDTVSGALSMPQMTDTASGGLSASLMRDTASGAMSTSQMTATVSGGMSMPLMRAQDPGVMPASLMRAKVSGKMLSQPMSTQDPGGMSMSPMKSMTAGGMQMNSPTSDVMSTPTVRAWTSETMSTPLMRTSDPGERPSLLTRASSSGEMSLPLMRAPASGEIATPLRSPAYGAMSAPQMTATASGMMSSMPQVKAPISGAMSMPLTRSTASGGMSMPLMRAPDSRVTSTSQMMPTASGDMCTLPVRAPASGGVSSPLVRAPASGTMSTPLRRPSACETVSTELMRASASGHMSTAQTTAMVSGGMSKPLMRAPASGTMPMPLMSAMASGEMSMPLMETMASGATSTLQTSVANSRSMSLSQTTYTVSGRMATAPIRASASGARSTSFMRASVSGSMPMPLPRATASGCGMGMSMPQMTATDSRGMSTPLMRASGPGTMSTPQTAFGVMSTPEIKATDSGEASTSHINITASGSKPTSHMTATTPETAKPPPKEVPSFGMLTPALCYLLEEQEAARGSCSVEEEMEIDEEKQMKGFLDDSERMAFLVSLHLGAAERWFILQMEVGEPLSHENKSFLRRSQGIYDSLSEIDILSAVLCHPKQGQKSVRQYATDFLLLARHLSWSDAILRTRFLEGLSEAVTTKMGRIFLKVAGSLKELIDRSLYTECQLAEEKDSPGNSSQVLPTACKRNNEEAMGNELSSQQQTEEHQHVSKRCYYLKEHGDPQEGLHDHLGQSTGHHQKAHTNK"},{"id":"SEQ_09153","a":"Q9HCK4","g":"ROBO2","d":"Roundabout homolog 2","L":1378,"m":[{"c":"[IF]xxxPx[DN][QV]xψxx[GDE]xxxx[LF]xC(x){5,6}PxP[TAV][IV]xWxK-(x){25,36}D[EAT]GxYxCx[AG]xxxxG(x){7,8}L[ETD]V","u":"84-96","sp":"periodic","x":"structured_like","cf":"high","why":"Five periodic ~84-96 aa structured repeats in the N-terminal half separated by short 5-10 aa linkers, anchored by invariant C, PxP[TAV][IV]xWxK-, D[EAT]GxYxC, downstream G, and C-terminal L[ETD]V motifs.","i":[[33,128,"IVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEV"],[135,221,"FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTV"],[227,310,"FLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV"],[316,408,"FVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEV"],[420,505,"ILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV"]]},{"c":"P(x){6,15}[ST][VI]x[LV][ST]W(x){11,14}Yx[IV]x(x){24,29}[GN]Lxx[GN][TVI][ITQ]YxφxV[RA][AP](x){4,6}G","u":"78-85","sp":"dispersed","x":"structured_like","cf":"high","why":"Three ~78-85 aa structured repeats in the central region (residues 524-823) separated by 17-41 aa linkers, defined by conserved N-terminal P, [ST][VI]x[LV][ST]W, central Yx[IV], and C-terminal [GN]Lxx[GN][TVI][ITQ]YxφxV[RA][AP](x){4,6}G beta-strand anchors.","i":[[524,602,"PPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQG"],[644,721,"PVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQG"],[739,823,"PPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVG"]]}],"s":"MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLNAGDPSYPWLADSWPATSLPVNNSNSGPNEIGNFGRGDVLPPVPGQGDKTATMLSDGAIYSSIDFTTKTSYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQNKGNNGGKGGKKKKNKNSSKPQKNNGSTWANVPLPPPPVQPLPGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDELEEDDDRVPTPPVRGVASSPAISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNNQPPQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVTGKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEEALVPYSKPSFPSPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIGYMGSNSQGQFTGEL"},{"id":"SEQ_09165","a":"Q8IWS0","g":"PHF6","d":"PHD finger protein 6","L":365,"m":[{"c":"KCGFC(x){8,10}GxLxIxxxxKφAAH[HY]KCMLFSS(x){11,12}φG[GD]F[SD]IxxVx[KQ]EIKRGx+ψxC[ST]LCxxPGATIGC-ψKxCx+TYHYHC[AG]ψxDKAxφxExxSxGIYxψYC+xH","u":"116-119","sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 116-119 aa cysteine-rich structured domains separated by a 79-aa disordered linker, sharing invariant KCGFC, KCMLFSS, EIKRG, PGATIGC, TYHYHC, and GIYxψYC+xH motifs with only two short variable internal loops.","i":[[16,131,"KCGFCKSNRDKECGQLLISENQKVAAHHKCMLFSSALVSSHSDNESLGGFSIEDVQKEIKRGTKLMCSLCHCPGATIGCDVKTCHRTYHYHCALHDKAQIREKPSQGIYMVYCRKH"],[211,329,"KCGFCHVGEEENEARGKLHIFNAKKAAAHYKCMLFSSGTVQLTTTSRAEFGDFDIKTVLQEIKRGKRMKCTLCSQPGATIGCEIKACVKTYHYHCGVQDKAKYIENMSRGIYKLYCKNH"]]}],"s":"MSSSVEQKKGPTRQRKCGFCKSNRDKECGQLLISENQKVAAHHKCMLFSSALVSSHSDNESLGGFSIEDVQKEIKRGTKLMCSLCHCPGATIGCDVKTCHRTYHYHCALHDKAQIREKPSQGIYMVYCRKHKKTAHNSEADLEESFNEHELEPSSPKSKKKSRKGRPRKTNFKGLSEDTRSTSSHGTDEMESSSYRDRSPHRSSPSDTRPKCGFCHVGEEENEARGKLHIFNAKKAAAHYKCMLFSSGTVQLTTTSRAEFGDFDIKTVLQEIKRGKRMKCTLCSQPGATIGCEIKACVKTYHYHCGVQDKAKYIENMSRGIYKLYCKNHSGNDERDEEDEERESKSRGKVEIDQQQLTQQQLNGN"},{"id":"SEQ_09170","a":"H0YKK7","g":"GOLGA6L19","d":"Putative golgin subfamily A member 6-like protein 19","L":550,"m":[{"c":"[ER]QEERL[CRH]","u":7,"sp":"tandem","x":"mixed","cf":"high","why":"Head-to-tail array of 22 nearly identical 7-aa units (positions 196-349) with an invariant QEERL core and [CRH] C-terminal position (predominantly C and alternating R/C), far exceeding generic heptad or charged-rod sequence degeneracy observed in the flanking helices.","i":[[196,202,"RQEERLR"],[203,209,"EQEERLH"],[210,216,"EQEERLH"],[217,223,"EQEERLC"],[224,230,"EQEERLR"],[231,237,"EQEERLC"],[238,244,"EQEERLR"],[245,251,"EQEERLC"],[252,258,"EQEERLR"],[259,265,"EQEERLC"],[266,272,"EQEERLR"],[273,279,"EQEERLC"],[280,286,"EQEERLR"],[287,293,"EQEERLC"],[294,300,"EQEERLR"],[301,307,"EQEERLC"],[308,314,"EQEERLR"],[315,321,"EQEERLC"],[322,328,"EQEERLC"],[329,335,"EQEERLC"],[336,342,"EQEERLC"],[343,349,"EQEERLC"]]}],"s":"MWPQPRLPPHPAMSEKTQQGKLAAAKKKLKAYWQRKSPGIPAGANRKKKVNGSSPDTATSGGYHSPGDSATGVYGEGRASSTTLQDLESQYQELAVALDSSSAIISQLTENINSLVRTSKEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLHEQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLCEQEERLCEQEERLCEQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLDEVEELLEQERLRQQDERLWQQETLRELERLRELERLRELERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKELEKSGGAEEPRGSESAAAARPVPGAPVPQGAWMCGQAGWTPQEHPGLSGEAVGTGEAAGGAEEAACHSFRAAENRELNITII"},{"id":"SEQ_09193","a":"O94854","g":"MACF1","d":"Microtubule-actin cross-linking factor 1, isoforms 6/7","L":3515,"m":[{"c":"[PL]EE[PS][TA]SPAA[AS]VP[TP]","u":13,"sp":"tandem","x":"disordered_like","cf":"high","why":"26-copy tandem 13-mer array in the central proline/alanine/glutamate-rich disordered region (residues 984-1328, with one 7-aa partial-unit interruption PAAMVAT), anchored by invariant A8 and V11 plus highly conserved [PL]1-E2-E3, P7, and P12-[TP]13 positions.","i":[[984,996,"PEEPDTAAVRVST"],[997,1009,"PEEPASPAAAVPT"],[1010,1022,"PEEPTSPAAAVPT"],[1023,1035,"PEEPTSPAAAVPP"],[1036,1048,"PEEPTSPAAAVPT"],[1049,1061,"PEEPTSPAAAVPT"],[1062,1074,"PEEPTSPAAAVPT"],[1075,1087,"PEEPTSPAAAVPT"],[1088,1100,"PEEPTSPAAAVPT"],[1101,1113,"PEEPTSPAAAVPT"],[1114,1126,"PEEPASPAAAVPT"],[1127,1139,"PEEPASPAAAVPT"],[1140,1152,"PEEPAFPAPAVPT"],[1153,1165,"PEESASAAVAVPT"],[1166,1178,"PEESASPAAAVPT"],[1179,1191,"PAESASFAAVVAT"],[1192,1204,"LEEPTSPAASVPT"],[1212,1224,"LEEFTSPAASVPT"],[1225,1237,"SEEPASLAAAVSN"],[1238,1250,"PEEPTSPAAAVPT"],[1251,1263,"LEEPTSSAAAVLT"],[1264,1276,"PEELSSPAASVPT"],[1277,1289,"PEEPASPAAAVSN"],[1290,1302,"LEEPASPAAAVPT"],[1303,1315,"PEVAAIPAASVPT"],[1316,1328,"PEVPAIPAAAVPP"]]},{"c":"xxψxxφxxxΩxxxxxxxxx+xxxLxxxψxφxxxΩxxxxxφxxxWψ(x){24,33}ψxxH+xxxxxψxxxxxxxxxxxxxxxxxxxxxxxx","u":"104-113","sp":"tandem","x":"structured_like","cf":"high","why":"15 tandem ~104-113 aa alpha-helical bundle repeats spanning residues 1443-3084, featuring an ungapped 45-aa N-terminal core with conserved aromatic W/Y at position 10, basic/leucine register, aromatic F/Y at position 34, and Wψ motif at positions 44-45 followed by a proline turn and H+ anchor.","i":[[1443,1551,"HDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKIT"],[1552,1662,"GQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEK"],[1663,1769,"LDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLD"],[1770,1878,"KLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQ"],[1879,1989,"EKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKY"],[1990,2102,"QKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQ"],[2103,2211,"DKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVR"],[2212,2321,"KSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIR"],[2322,2430,"EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLR"],[2431,2540,"SRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE"],[2541,2649,"QSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIK"],[2650,2759,"NLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLD"],[2760,2867,"NFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVK"],[2868,2971,"GQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDC"],[2981,3084,"IIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFI"]]},{"c":"φφxxφD+D[QG]DGxIxxxEFψx[GA]ψx[AP]oK","u":26,"sp":"dispersed","x":"structured_like","cf":"high","why":"Pair of strongly conserved 26-aa calcium-binding-like helix-loop-helix repeats near the C-terminus (residues 3176-3236, separated by a 10-aa linker), sharing invariant D6-D8-D10-G11-I13-E17-F18-K26 anchors and flanking hydrophobic core positions.","i":[[3176,3201,"FFRRIDKDQDGKITRQEFIDGILASK"],[3212,3237,"VADIFDRDGDGYIDYYEFVAALHPNK"]]}],"s":"MGKPLSRPDCLRRNPSCLGKGEEEDGYIEDCYVPQRSIYDTMRINEQIDQGSKLNQTSKSTMEKMEGSTISSNGTLGAASNVFESRAPEGKKLDERIIFDALKLSSDVQKSAPVPPRRRPNAERKDNVNRRSWKSFMPPNFPEFAERIEASLSEVSEAGASNPSLQEKKESSSALTESSGHLDHREPQSESVTLEHVSKSIGIPEVQDFKNLSGDCQDFRFQQHSANPPHEFQPVESEAVATSGNTDVMQESRFSSATWPRATKSLAKGGFSEKQHPLGDTACTVEMPPLSPCLSEELLDPELHVLITPSLREKTESELKFEEDERWIMMEAEGEWEEEKLSDREKTFLMADEKNSLADIFEEREQANTAVVEDGSDCLAAVLRTFGHLSLGQICCPDDPQPAKDQLATVPKDIPLDCDCVLTGEDILGEVANRTAQGLEGLVSDSACTVGTIDAEQLSDTDSVQMFLELEKECLCEEGVTPLVELQNQISSEGLAASQDAENLLVISHFSGAALEKEQHLGLLHVRAKDYDTRLDCGYFNTLDSSQVPNAVELIAHVDIMRDTSTVSKEECEKVPFSPRTAEFKSRQPADLDSLEKLDPGGLLNSDHRVSHEEKLSGFIASELAKDNGSLSQGDCSQTEGNGEECIERVTFSFAFNHELTDVTSGPEVEVLYESNLLTDEIHLESGNVTVNQENNSLTSMGNVVTCELSVEKVCDEDGEAKELDYQATLLEDQAPAHFHRNFPEQVFQDLQRKSPESEILSLHLLVEELRLNPDGVETVNDTKPELNVASSEGGEMERRDSDSFLNIFPEKQVTKAGNTEPVLEEWIPVLQRPSRTAAVPTVKDALDAALPSPEEGTSIAAVPAPEGTAVVAALVPFPHEDILVASIVSLEEEDVTAAAVSAPERATVPAVTVSVPEGTAAVAAVSSPEETAPAVAAAITQEGMSAVAGFSPEWAALAITVPITEEDGTPEGPVTPATTVHAPEEPDTAAVRVSTPEEPASPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPPPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPASPAAAVPTPEEPASPAAAVPTPEEPAFPAPAVPTPEESASAAVAVPTPEESASPAAAVPTPAESASFAAVVATLEEPTSPAASVPTPAAMVATLEEFTSPAASVPTSEEPASLAAAVSNPEEPTSPAAAVPTLEEPTSSAAAVLTPEELSSPAASVPTPEEPASPAAAVSNLEEPASPAAAVPTPEVAAIPAASVPTPEVPAIPAAAVPPMEEVSPIGVPFLGVSAHTDSVPISEEGTPVLEEASSTGMWIKEDLDSLVFGIKEVTSTVLHGKVPLAATAGLNSDEMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGLNKPSKIPTMSKKTTTASPRTPGPKR"},{"id":"SEQ_09195","a":"Q96JM4","g":"LRRIQ1","d":"Leucine-rich repeat- and IQ domain-containing protein 1","L":1722,"m":[{"c":"[LI]xxψxxxx[NC]x[LI](x){10,15}","u":"21-26","sp":"tandem","x":"structured_like","cf":"high","why":"Eleven 21-26 aa leucine-rich repeat units with a strictly conserved [LI]xxψxxxx[NC]x[LI] N-terminal core (Asn at position 9 in 10/11 copies, Cys in copy 1), arranged in two head-to-tail tandem sub-arrays of 4 and 7 copies separated by a 64-aa intervening segment.","i":[[820,841,"LQFLSLRRCGLTSLHSLSNCKK"],[842,862,"LKYIDAQENHIEAIECENLEN"],[863,884,"LCVVLLNKNQLTSLHGLDGCTN"],[885,906,"IQCLELSYNKITRIGYSFFLEE"],[971,992,"LQQLILDHNQLINTKGLCDTPT"],[993,1014,"IVYLDCSHNHLTDVEGVENCGL"],[1015,1036,"LQILKLQGNYLSELPSLENLVL"],[1037,1060,"LRELHLDDNSISTVEAFSSYWLPL"],[1061,1082,"LQNITISQNSLTKIVPLFHFVS"],[1083,1108,"LEKLDVSHNCLSDLKSAIKWFDACYS"],[1109,1130,"LHELSLTGNPLLQETNWRDSLL"]]},{"c":"AA[VI]xIQ[AS]x[YW]+[AG][FY]ψφ","u":14,"sp":"dispersed","x":"mixed","cf":"high","why":"Three dispersed 14-aa amphipathic helical motifs (one N-terminal, two C-terminal) anchored by invariant AA at positions 1-2 and IQ at positions 5-6, followed by conserved aromatic ([YW], [FY]), basic (+), and hydrophobic (ψφ) positions.","i":[[286,299,"AAVKIQAKYKAFVA"],[1338,1351,"AAVVIQSYWRGYLM"],[1398,1411,"AAILIQAVWKGFIL"]]}],"s":"MDDDDAKLKAEIEAELDKLSISSLEKEDIESDAKSETQSDDSDTDSVELPESVLHCINIIKNRSKAVEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEFMRSKTDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHAPCEGLSNYNAESSMVSKEVNSLKSEIRNISEKCHENAPEPDSMTCCVSESTLLYSIEERRLAWIKSFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPALDKLEILRCGPWDTLQQVTTVTFQDLPGCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIECENLENLCVVLLNKNQLTSLHGLDGCTNIQCLELSYNKITRIGYSFFLEEKLVDNAGFCHHLGTSTSYLSLAQVWIPTGLCWSWIPITSLTKNSDCNFLISHLYWNCGLESLKNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSELPSLENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDLKSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLKVLPALRILNGNILNSNSESRTEEHNQLGSAGFLALCQSQIREFNLLIENYITGKGDVFTLDTAENLCHYFKKLMILSTEYRHAHERGDVTITKKDESEAQKNHLAPTNSDSTLQNGVFYSCAREGEPDSPDIPEKWMDSVSSHSPLSKSATCENMEGRHQEILVCQKREDSKASSIPTIRIPFKEVVMTNSLLRNHQNIEPSEKIMAAVVIQSYWRGYLMRRQTHFSTRLHTAATEGLPNSSIKNQTILKKGKRENIVNIRKQREKAAILIQAVWKGFILRKKLTTALEAIKNEESDEEYREIDLEDFIFDEAALEEEWLALDSTRFPSQTLLLSNQLHWPKIPGNLKWDDTSFNLPSNPAQAWLCNDKENLSSSEHTQFNSRSENKTSSWTPESKTSRKSLLKSEKEKKISEEWGFKDISTAQQMLKRAQKMKSKKLKKKIDSTVRLALFKNNENKVSLPKSPKMVQPRRDGYFEGIEEDPIHKDTTANEKLERNREYTYQWLHTQVGVHETTSSRNMKCNHFLPELDPDVLNGGRVQLVARLVSREDTDLDLFSMTNGSALSVNREKKNQAHRHSAGSSSKLWFPSKLI"},{"id":"SEQ_09200","a":"Q8N302","g":"AGGF1","d":"Angiogenic factor with G patch and FHA domains 1","L":714,"m":[{"c":"xx[TN][GQ]φ[YS][YF][DY]","u":8,"sp":"tandem","x":"mixed","cf":"high","why":"Five contiguous head-to-tail 8-aa repeats anchored by a conserved TG/NQ turn-like dyad ([TN][GQ] at positions 3-4), a hydrophobic residue at position 5 (F/L/I), an aromatic-rich doublet ([YS][YF] at positions 6-7), and Asp at position 8 in the first four copies.","i":[[203,210,"SQTGFSYD"],[211,218,"ENTGLYFD"],[219,226,"HSTGFYYD"],[227,234,"SENQLYYD"],[235,242,"PSTGIYYY"]]}],"s":"MASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQNAESNNQELRTQVEELSKILQRGRNEDNKKSDVEVQTENHAPWSISDYFYQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVENDAYPGTDRTENVKYRQVDHFASNSQEPASALATEDTSLEGSSLAESLRAAAEAAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFHSRVDLQPYPTSSTKQSKDKKLKKKRKDPDSSATNEEKDLNSEDQKAFSVEHTSCNEEENFANMKKKAKIGIHHKNSPPKVTVPTSGNTIESPLHENISNSTSFKDEKIMETDSEPEEGEITDSQTEDSYDEAITSEGNVTAEDSEDEDEDKIWPPCIRVIVIRSPVLQIGSLFIITAVNPATIGREKDMEHTLRIPEVGVSKFHAEIYFDHDLQSYVLVDQGSQNGTIVNGKQILQPKTKCDPYVLEHGDEVKIGETVLSFHIHPGSDTCDGCEPGQVRAHLRLDKKDESFVGPTLSKEEKELERRKELKKIRVKYGLQNTEYEDEKTLKNPKYKDRAGKRREQVGSEGTFQRDDAPASVHSEITDSNKGRKMLEKMGWKKGEGLGKDGGGMKTPIQLQLRRTHAGLGTGKPSSFEDVHLLQNKNKKNWDKARERFTENFPETKPQKDDPGTMPWVKGTLE"},{"id":"SEQ_09209","a":"Q5JWF2","g":"GNAS","d":"Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas","L":1037,"m":[{"c":"G[GS]YSPPPEE[AT]MPFEφ-","u":16,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three highly conserved 16-aa linear motifs in the N-terminal disordered region separated by 44-aa and 46-aa linkers, sharing 12 invariant anchor positions (G, YSPPPEE, MPFE) plus C-terminal hydrophobic and acidic positions.","i":[[92,107,"GSYSPPPEEAMPFEAE"],[152,167,"GGYSPPPEEAMPFEFD"],[214,229,"GGYSPPPEETMPFELD"]]},{"c":"[AE]DPD[SA]G[AT][ATF][PA]","u":9,"sp":"tandem","x":"disordered_like","cf":"high","why":"Seven 9-aa repeats in the central proline/alanine-rich disordered region anchored by invariant DPD and G positions; the first four copies are head-to-tail and the last three are separated by 3-aa [AD]AP spacers.","i":[[400,408,"ADPDSGATP"],[409,417,"EDPDSGTAP"],[418,426,"ADPDSGAFA"],[427,435,"ADPDSGAAP"],[439,447,"ADPDSGAAP"],[451,459,"ADPDSGAAP"],[463,471,"ADPDAGAAP"]]}],"s":"MGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNPAFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCSQLLLQVPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSAVRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDSGAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSPEIQAADPPTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRSESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL"},{"id":"SEQ_09214","a":"Q9H0B6","g":"KLC2","d":"Kinesin light chain 2","L":622,"m":[{"c":"xx[LK]xxL[AVG]xx[YC]xx[QR][GN]+φxx[AV]xx[LY]xxx[AI][LS]xxxxxxxxxxxxxxx","u":42,"sp":"tandem","x":"structured_like","cf":"high","why":"Six 42-aa structured helical repeats with conserved L, Y/C, QG+φ, and hydrophobic core positions; copies 1-5 form a contiguous head-to-tail tandem array (with copies 1-4 conserving a C-terminal Gx[DF][HD]PxVA turn) and copy 6 follows a 41-aa loop insertion.","i":[[199,240,"RTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVA"],[241,282,"TMLNILALVYRDQNKYKEAAHLLNDALAIREKTLGKDHPAVA"],[283,324,"ATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVA"],[325,366,"KQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNVA"],[367,408,"KTKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFGSVNGDN"],[450,491,"TTLRSLGALYRRQGKLEAAHTLEDCASRNRKQGLDPASQTKV"]]}],"s":"MAMMVFPREEKLSQDEIVLGTKAVIQGLETLRGEHRALLAPLVAPEAGEAEPGSQERCILLRRSLEAIELGLGEAQVILALSSHLGAVESEKQKLRAQVRRLVQENQWLREELAGTQQKLQRSEQAVAQLEEEKQHLLFMSQIRKLDEDASPNEEKGDVPKDTLDDLFPNEDEQSPAPSPGGGDVSGQHGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFGSVNGDNKPIWMHAEEREESKDKRRDSAPYGEYGSWYKACKVDSPTVNTTLRSLGALYRRQGKLEAAHTLEDCASRNRKQGLDPASQTKVVELLKDGSGRRGDRRSSRDMAGGAGPRSESDLEDVGPTAEWNGDGSGSLRRSGSFGKLRDALRRSSEMLVKKLQGGTPQEPPNPRMKRASSLNFLNKSVEEPTQPGGTGLSDSRTLSSSSMDLSRRSSLVG"},{"id":"SEQ_09232","a":"O75362","g":"ZNF217","d":"Zinc finger protein 217","L":1048,"m":[{"c":"CxxCxxxxxxxxxψxxH(x){3,4}H","u":"21-22","sp":"dispersed","x":"structured_like","cf":"high","why":"Eight C2H2-type zinc-coordinating repeats defined by invariant CxxC and H(x){3,4}H chelators, a conserved large aliphatic residue (L/V) three positions before the first His, and a frequent aromatic Phe four positions after the second Cys. Copies occur as both closely spaced pairs (7-aa linkers) and widely spaced units across the sequence.","i":[[67,88,"CMFCSQTFTHSEDLNKHVLMQH"],[130,150,"CEVCGQTFRVAFDVEIHMRTH"],[158,178,"CNMCGRRFKEPWFLKNHMRTH"],[218,238,"CMVCGFLFPNKESLIEHRKVH"],[377,397,"CSECGKAFRTYHQLVLHSRVH"],[473,493,"CSYCGKFFRSNYYLNIHLRTH"],[501,521,"CEFCEYAAAQKTSLRYHLERH"],[712,733,"CPFCTFKTFYPEVLMMHQRLEH"]]}],"s":"MQSKVTGNMPTQSLLMYMDGPEVIGSSLGSPMEMEDALSMKGTAVVPFRATQEKNVIQIEGYMPLDCMFCSQTFTHSEDLNKHVLMQHRPTLCEPAVLRVEAEYLSPLDKSQVRTEPPKEKNCKENEFSCEVCGQTFRVAFDVEIHMRTHKDSFTYGCNMCGRRFKEPWFLKNHMRTHNGKSGARSKLQQGLESSPATINEVVQVHAAESISSPYKICMVCGFLFPNKESLIEHRKVHTKKTAFGTSSAQTDSPQGGMPSSREDFLQLFNLRPKSHPETGKKPVRCIPQLDPFTTFQAWQLATKGKVAICQEVKESGQEGSTDNDDSSSEKELGETNKGSCAGLSQEKEKCKHSHGEAPSVDADPKLPSSKEKPTHCSECGKAFRTYHQLVLHSRVHKKDRRAGAESPTMSVDGRQPGTCSPDLAAPLDENGAVDRGEGGSEDGSEDGLPEGIHLDKNDDGGKIKHLTSSRECSYCGKFFRSNYYLNIHLRTHTGEKPYKCEFCEYAAAQKTSLRYHLERHHKEKQTDVAAEVKNDGKNQDTEDALLTADSAQTKNLKRFFDGAKDVTGSPPAKQLKEMPSVFQNVLGSAVLSPAHKDTQDFHKNAADDSADKVNKNPTPAYLDLLKKRSAVETQANNLICRTKADVTPPPDGSTTHNLEVSPKEKQTETAADCRYRPSVDCHEKPLNLSVGALHNCPAISLSKSLIPSITCPFCTFKTFYPEVLMMHQRLEHKYNPDVHKNCRNKSLLRSRRTGCPPALLGKDVPPLSSFCKPKPKSAFPAQSKSLPSAKGKQSPPGPGKAPLTSGIDSSTLAPSNLKSHRPQQNVGVQGAATRQQQSEMFPKTSVSPAPDKTKRPETKLKPLPVAPSQPTLGSSNINGSIDYPAKNDSPWAPPGRDYFCNRSASNTAAEFGEPLPKRLKSSVVALDVDQPGANYRRGYDLPKYHMVRGITSLLPQDCVYPSQALPPKPRFLSSSEVDSPNVLTVQKPYGGSGPLYTCVPAGSPASSSTLEGKRPVSYQHLSNSMAQKRNYENFIGNAHYRPNDKKT"},{"id":"SEQ_09271","a":"Q96JB3","g":"HIC2","d":"Hypermethylated in cancer 2 protein","L":615,"m":[{"c":"[FY]xCxxCxxx[FY]xxxxx[LM]xxHxxxH","u":23,"sp":"dispersed","x":"structured_like","cf":"high","why":"Five 23-residue structured repeats anchored by invariant CxxC and HxxxH pairs alongside strictly conserved [FY] (positions 1 and 10) and [LM] (position 16) core residues; one upstream copy is separated by a 41-residue acidic/polar linker from four C-terminal copies spaced by regular 5-residue [KR]P-containing linkers.","i":[[442,464,"YVCIPCAKGFPSSEQLNAHVETH"],[505,527,"FKCSVCEKTYKDPATLRQHEKTH"],[533,555,"FPCNICGKMFTQRGTMTRHMRSH"],[561,583,"FACDECGMRFTRQYRLTEHMRVH"],[589,611,"YECQLCGGKFTQQRNLISHLRMH"]]}],"s":"MVSGPLALRWCAWAGRGDMGPDMELPSHSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHDNLINLDTDMVSSTVFQQILDFIYTGKLLPSDQPAEPNFSTLLTAASYLQLPELAALCRRKLKRAGKPFGSGRAGSTGMGRPPRSQRLSTASVIQARYQGLVDGRKGAHAPQELPQAKGSDDELFLGGSNQDSVQGLGRAVCPAGGEAGLGGCSSSTNGSSGGCEQELGLDLSKKSPPLPPATPGPHLTPDDAAQLSDSQHGSPPAASAPPVANSASYSELGGTPDEPMDLEGAEDNHLSLLEAPGGQPRKSLRHSTRKKEWGKKEPVAGSPFERREAGPKGPCPGEEGEGVGDRVPNGILASGAGPSGPYGEPPYPCKEEEENGKDASEDSAQSGSEGGSGHASAHYMYRQEGYETVSYGDNLYVCIPCAKGFPSSEQLNAHVETHTEEELFIKEEGAYETGSGGAEEEAEDLSAPSAAYTAEPRPFKCSVCEKTYKDPATLRQHEKTHWLTRPFPCNICGKMFTQRGTMTRHMRSHLGLKPFACDECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLISHLRMHTSPS"},{"id":"SEQ_09281","a":"Q9H1K0","g":"RBSN","d":"Rabenosyn-5","L":784,"m":[{"c":"NPFxx[EDP][DST]","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Six dispersed copies in the C-terminal P/S/E-rich disordered region (residues 626-724) anchored by an invariant NPF tripeptide followed by an acidic/proline/polar tail (predominantly NPFxEED).","i":[[626,632,"NPFDEED"],[662,668,"NPFEEED"],[677,683,"NPFIQPD"],[688,694,"NPFSEED"],[709,715,"NPFEEPT"],[718,724,"NPFEMDS"]]},{"c":"LLQQIxNIxxΩIxxAKxxGRψDEVxxLoENLR[QE]L","u":34,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two-copy internal duplication of a 34-residue structured helical module (residues 459-492 and 738-771) sharing 20/34 identical positions plus conserved aromatic and aliphatic substitutions.","i":[[459,492,"LLQQIHNITSFIRQAKAAGRMDEVRTLQENLRQL"],[739,772,"LLQQIDNIKAYIFDAKQCGRLDEVEVLTENLREL"]]}],"s":"MASLDDPGEVREGFLCPLCLKDLQSFYQLHSHYEEEHSGEDRDVKGQIKSLVQKAKKAKDRLLKREGDDRAESGTQGYESFSYGGVDPYMWEPQELGAVRSHLSDFKKHRAARIDHYVVEVNKLIIRLEKLTAFDRTNTESAKIRAIEKSVVPWVNDQDVPFCPDCGNKFSIRNRRHHCRLCGSIMCKKCMELISLPLANKLTSASKESLSTHTSPSQSPNSVHGSRRGSISSMSSVSSVLDEKDDDRIRCCTHCKDTLLKREQQIDEKEHTPDIVKLYEKLRLCMEKVDQKAPEYIRMAASLNAGETTYSLEHASDLRVEVQKVYELIDALSKKILTLGLNQDPPPHPSNLRLQRMIRYSATLFVQEKLLGLMSLPTKEQFEELKKKRKEEMERKRAVERQAALESQRRLEERQSGLASRAANGEVASLRRGPAPLRKAEGWLPLSGGQGQSEDSDPLLQQIHNITSFIRQAKAAGRMDEVRTLQENLRQLQDEYDQQQTEKAIELSRRQAEEEDLQREQLQMLRERELEREREQFRVASLHTRTRSLDFREIGPFQLEPSREPRTHLAYALDLGSSPVPSSTAPKTPSLSSTQPTRVWSGPPAVGQERLPQSSMPQQHEGPSLNPFDEEDLSSPMEEATTGPPAAGVSLDPSARILKEYNPFEEEDEEEEAVAGNPFIQPDSPAPNPFSEEDEHPQQRLSSPLVPGNPFEEPTCINPFEMDSDSGPEAEEPIEEELLLQQIDNIKAYIFDAKQCGRLDEVEVLTENLRELKHTLAKQKGGTD"},{"id":"SEQ_09297","a":"Q96JP5","g":"ZFP91","d":"E3 ubiquitin-protein ligase ZFP91","L":570,"m":[{"c":"φxC(x){2,4}C[GA]xxxxxxxx[LV]xxH(x){3,4}H","u":"23-26","sp":"periodic","x":"structured_like","cf":"high","why":"Five periodic C2H2-type zinc finger repeats (residues 311-453) separated by 5-7 aa linkers, defined by a conserved N-terminal hydrophobic residue, invariant Cxx(xx)C and Hxxx(x)H metal-coordinating pairs, and a conserved [GA]/aliphatic core.","i":[[311,336,"VRCEMEGCGTVLAHPRYLQHHIKYQH"],[342,366,"YVCPHPSCGRLFRLQKQLLRHAKHH"],[372,394,"YICEYCARAFKSSHNLAVHRMIH"],[400,422,"LQCEICGFTCRQKASLNWHMKKH"],[430,453,"FSCNICGKKFEKKDSVVAHKAKSH"]]}],"s":"MPGETEEPRPPEQQDQEGGEAAKAAPEEPQQRPPEAVAAAPAGTTSSRVLRGGRDRGRAAAAAAAAAVSRRRKAEYPRRRRSSPSARPPDVPGQQPQAAKSPSPVQGKKSPRLLCIEKVTTDKDPKEEKEEEDDSALPQEVSIAASRPSRGWRSSRTSVSRHRDTENTRSSRSKTGSLQLICKSEPNTDQLDYDVGEEHQSPGGISSEEEEEEEEEMLISEEEIPFKDDPRDETYKPHLERETPKPRRKSGKVKEEKEKKEIKVEVEVEVKEEENEIREDEEPPRKRGRRRKDDKSPRLPKRRKKPPIQYVRCEMEGCGTVLAHPRYLQHHIKYQHLLKKKYVCPHPSCGRLFRLQKQLLRHAKHHTDQRDYICEYCARAFKSSHNLAVHRMIHTGEKPLQCEICGFTCRQKASLNWHMKKHDADSFYQFSCNICGKKFEKKDSVVAHKAKSHPEVLIAEALAANAGALITSTDILGTNPESLTQPSDGQGLPLLPEPLGNSTSGECLLLEAEGMSKSYCSGTERVSLMADGKIFVGSGSSGGTEGLVMNSDILGATTEVLIEDSDSAGP"},{"id":"SEQ_09303","a":"Q96K83","g":"ZNF521","d":"Zinc finger protein 521","L":1311,"m":[{"c":"xxCxxC(x){3,5}φxxxxxφxxH(x){3,4}[HC]","u":"23-26","sp":"dispersed","x":"structured_like","cf":"high","why":"30 copies of a 23-26 aa CxxC...Hxxx(x)[HC] repeat distributed in closely spaced clusters and dispersed singletons across the protein, anchored by invariant CxxC cysteines, two conserved internal hydrophobic core positions (predominantly F/Y and L/I), a frequent N-terminal aromatic residue, and C-terminal Hx(3,4)[HC] ligands.","i":[[47,70,"HSCDSCLQVFESLSDITEHKINQC"],[118,140,"YPCQFCDKSFSRLSYLKHHEQSH"],[146,168,"FKCTYCSRLFKHKRSRDRHIKLH"],[174,196,"YHCSECDAAFSRSDHLKIHLKTH"],[202,224,"YKCAICRRGFLSSSSLHGHMQVH"],[246,269,"QKCSQCEEGFDFPEDLQKHIAECH"],[281,304,"LQCVYCHELFVEETSLMNHMEQVH"],[310,332,"NSCSICSESFHTVEELYSHMDSH"],[405,429,"YSCIYCNKQLFSSLAVLQIHLKTMH"],[437,460,"HICQYCLEVLPSLYNLNEHLKQVH"],[477,500,"YQCNFCSEVVNDLNTLQEHIRCSH"],[513,536,"FFCPHCYMGFLTDSSLEEHIRQVH"],[560,585,"YSCSYCTNSPIFNSVLKLNKHIKENH"],[634,656,"YICNQCGAKYTSLDSFQTHLKTH"],[664,686,"LTCPQCNKEFPNQESLLKHVTIH"],[694,717,"YICESCDKQFTSVDDLQKHLLDMH"],[722,745,"FRCTLCQEVFDSKVSIQLHLAVKH"],[752,775,"YRCTSCNWDFRNETDLQLHVKHNH"],[783,805,"HKCIFCGESFGTEVELQCHITTH"],[809,832,"YNCKFCSKAFHAIILLEKHLREKH"],[886,909,"YGCDICGAAYTMETLLQNHQLRDH"],[930,952,"YKCNVCSRTFFSENGLREHMQTH"],[959,981,"YMCPICGERFPSLLTLTEHKVTH"],[988,1010,"GNCRICKMPLQSEEEFLEHCQMH"],[1020,1042,"FRCVVCMQTVTSTLELKIHGTFH"],[1138,1161,"TRCSSCNVKFESESELQNHIQTIH"],[1195,1217,"YQCIKCQMVFYNEWDIQVHVANH"],[1225,1247,"HECKLCSQTFDSPAKLQCHLIEH"],[1256,1279,"FKCPVCFTVFVQANKLQQHIFSAH"],[1286,1309,"YDCTQCPQKFFFQTELQNHTMTQH"]]}],"s":"MSRRKQAKPRSLKDPNCKLEDKTEDGEALDCKKRPEDGEELEDEAVHSCDSCLQVFESLSDITEHKINQCQLTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDGSQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSESFHTVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYCNKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSHGFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPLALNYIHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLLKHVTIHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLHVKHNHLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEVELQTLLTNSQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQTHLGPVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGKGKVGGLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMIDEGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFSAHGQEDKIYDCTQCPQKFFFQTELQNHTMTQHSS"},{"id":"SEQ_09323","a":"Q13651","g":"IL10RA","d":"Interleukin-10 receptor subunit alpha","L":578,"m":[{"c":"[GN][SQ][TD]DSG[FI]","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed copies within a ~90-aa polar/proline-rich disordered C-terminal segment share an invariant DSG core followed by a bulky hydrophobic [FI] anchor and a conserved polar/acidic N-terminal flank ([GN][SQ][TD]).","i":[[315,321,"GSTDSGF"],[366,372,"NSTDSGI"],[397,403,"GQDDSGI"]]}],"s":"MLPCLVVLLAALLSLRLGSDAHGTELPSPPSVWFEAEFFHHILHWTPIPNQSESTCYEVALLRYGIESWNSISNCSQTLSYDLTAVTLDLYHSNGYRARVRAVDGSRHSNWTVTNTRFSVDEVTLTVGSVNLEIHNGFILGKIQLPRPKMAPANDTYESIFSHFREYEIAIRKVPGNFTFTHKKVKHENFSLLTSGEVGEFCVQVKPSVASRSNKGMWSKEECISLTRQYFTVTNVIIFFAFVLLLSGALAYCLALQLYVRRRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEAFLKVSPELKNLDLHGSTDSGFGSTKPSLQTEEPQFLLPDPHPQADRTLGNREPPVLGDSCSSGSSNSTDSGICLQEPSLSPSTGPTWEQQVGSNSRGQDDSGIDLVQNSEGRAGDTQGGSALGHHSPPEPEVPGEEDPAAVAFQGYLRQTRCAEEKATKTGCLEEESPLTDGLGPKFGRCLVDEAGLHPPALAKGYLKQDPLEMTLASSGAPTGQWNQPTEEWSLLALSSCSDLGISDWSFAHDLAPLGCVAAPGGLLGSFNSDLVTLPLISSLQSSE"},{"id":"SEQ_09324","a":"Q5TID7","g":"CCDC181","d":"Coiled-coil domain-containing protein 181","L":509,"m":[{"c":"[AV]F+xWL[KRQ]+K[RH]x[EQ]x[LM]xx[QR][QR]","u":18,"sp":"periodic","x":"structured_like","cf":"high","why":"Three periodic C-terminal amphipathic/basic alpha-helical repeats separated by regular 21-22 aa linkers, anchored by invariant F, W, L, and K positions alongside conserved basic (+), aliphatic ([LM]), and polar ([EQ], [QR]) registers.","i":[[375,392,"VFKAWLQKKREQVLEMRR"],[414,431,"AFRLWLKKKHEEQMKERQ"],[454,471,"AFKQWLRRKRMEKMAEQQ"]]}],"s":"MNENKDTDSKKSEEYEDDFEKDLEWLINENEKSDASIIEMACEKEENINQDLKENETVMEHTKRHSDPDKSLQDEVSPRRNDIISVPGIQPLDPISDSDSENSFQESKLESQKDLEEEEDEEVRRYIMEKIVQANKLLQNQEPVNDKRERKLKFKDQLVDLEVPPLEDTTTFKNYFENERNMFGKLSQLCISNDFGQEDVLLSLTNGSCEENKDRTILVERDGKFELLNLQDIASQGFLPPINNANSTENDPQQLLPRSSNSSVSGTKKEDSTAKIHAVTHSSTGEPLAYIAQPPLNRKTCPSSAVNSDRSKGNGKSNHRTQSAHISPVTSTYCLSPRQKELQKQLEEKREKLKREEERRKIEEEKEKKRENDIVFKAWLQKKREQVLEMRRIQRAKEIEDMNSRQENRDPQQAFRLWLKKKHEEQMKERQTEELRKQEECLFFLKGTEGRERAFKQWLRRKRMEKMAEQQAVRERTRQLRLEAKRSKQLQHHLYMSEAKPFRFTDHYN"},{"id":"SEQ_09340","a":"Q99614","g":"TTC1","d":"Tetratricopeptide repeat protein 1","L":292,"m":[{"c":"[SI]xxφxx[ER][GA]xxxxKx[GD][DK]xx[EM]Axx[SD][YC][SK]x[AI]ψ[EQ]xxPS(x){1,6}","u":"34-39","sp":"tandem","x":"structured_like","cf":"high","why":"Three tandem 34-residue helical-hairpin repeats (with a 5-residue turn extension after the first copy) anchored by invariant K13, A20, P32, S33 plus conserved hydrophobic/small helical packing positions (φ4, [GA]8, [AI]27, ψ28).","i":[[116,154,"STRLKEEGNEQFKKGDYIEAESSYSRALEMCPSCFQKER"],[155,188,"SILFSNRAAARMKQDKKEMAINDCSKAIQLNPSY"],[189,222,"IRAILRRAELYEKTDKLDEALEDYKSILEKDPSI"]]}],"s":"MGEKSENCGVPEDLLNGLKVTDTQEAECAGPPVPDPKNQHSQSKLLRDDEAHLQEDQGEEECFHDCSASFEEEPGADKVENKSNEDVNSSELDEEYLIELEKNMSDEEKQKRREESTRLKEEGNEQFKKGDYIEAESSYSRALEMCPSCFQKERSILFSNRAAARMKQDKKEMAINDCSKAIQLNPSYIRAILRRAELYEKTDKLDEALEDYKSILEKDPSIHQAREACMRLPKQIEERNERLKEEMLGKLKDLGNLVLRPFGLSTENFQIKQDSSTGSYSINFVQNPNNNR"},{"id":"SEQ_09345","a":"P17600","g":"SYN1","d":"Synapsin-1","L":705,"m":[{"c":"[GT]RQ[TA]S[QV]x[GP][PA][GAV]P","u":11,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed 11-aa motifs in the C-terminal P/Q/G-rich disordered region sharing invariant R2, Q3, S5, and P11 anchors alongside tightly constrained [GT]1, [TA]4, [QV]6, [GP]8, [PA]9, and [GAV]10 positions.","i":[[445,455,"GRQTSQQPAGP"],[564,574,"TRQTSVSGPAP"],[601,611,"TRQASQAGPVP"]]},{"c":"[GS][PQ]QRQ[GA][GP]Px[QK]","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three non-overlapping dispersed 10-aa motifs in the C-terminal disordered region anchored by an invariant QRQ triad coupled to a conserved [GA][GP]P proline motif and flanking [GS]1/[QK]10 residues.","i":[[473,482,"GPQRQGPPLQ"],[553,562,"SPQRQAGPPQ"],[584,593,"GQQRQGPPQK"]]}],"s":"MNYLRRRLSDSNFMANLPNGYMTDLQRPQPPPPPPGAHSPGATPGPGTATAERSSGVAPAASPAAPSPGSSGGGGFFSSLSNAVKQTTAAAAATFSEQVGGGSGGAGRGGAASRVLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANGGFSVDMEVLRNGVKVVRSLKPDFVLIRQHAFSMARNGDYRSLVIGLQYAGIPSVNSLHSVYNFCDKPWVFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQDIASVVALTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEIFGGLDICAVEALHGKDGRDHIIEVVGSSMPLIGDHQDEDKQLIVELVVNKMAQALPRQRQRDASPGRGSHGQTPSPGALPLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQLAQKPSQDVPPPATAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQDEVKAETIRSLRKSFASLFSD"},{"id":"SEQ_09359","a":"Q8N8A6","g":"DDX51","d":"ATP-dependent RNA helicase DDX51","L":666,"m":[{"c":"A[EG]S[NS]EEAPGE[PR]S","u":12,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three head-to-tail 12-residue repeats in the N-terminal disordered tail sharing nine invariant positions (A..S.EEAPGE.S) and conservative [EG], [NS], and [PR] substitutions.","i":[[101,112,"AESNEEAPGEPS"],[113,124,"AGSSEEAPGEPS"],[125,136,"AGSSEEAPGERS"]]}],"s":"MALFYVARYPGPDAAAAAGPEGAEAGAHGRARALLERLQSRARERQQQREPAQTEAAASTEPATRRRRRPRRRRRVNDAEPGSPEAPQGKRRKADGEDAGAESNEEAPGEPSAGSSEEAPGEPSAGSSEEAPGERSTSASAEAAPDGPALEEAAGPLVPGLVLGGFGKRKAPKVQPFLPRWLAEPNCVRRNVTEDLVPIEDIPDVHPDLQKQLRAHGISSYFPVQAAVIPALLESAACGFLVGRGGYRPSDLCVSAPTGSGKTLAFVIPVVQALLSRVVCHIRALVVLPTKELAQQVSKVFNIYTDATPLRVSLVTGQKSLAKEQESLVQKTADGYRCLADIVVATPGRLVDHIDQTPGFSLQQLRFLIIDEADRMIDSMHQSWLPRVVAAAFQSEDPADPCALLQRRQAQAVTAASTCCPQMPLQKLLFSATLTQNPEKLQQLGLHQPRLFSTGLAHRGLEDTDGDGDSGKYAFPVGLTHHYVPCSLSSKPLVVLHLVLEMGFSRVLCFTNSRENSHRLFLLVQAFGGVDVAEFSSRYGPGQRRMILKQFEQGKIQLLISTDATARGIDVQGVELVVNYDAPQYLRTYVHRVGRTARAGKTGQAFTLLLKVQERRFLRMLTEAGAPELQRHELSSKLLQPLVPRYEEALSQLEESVKEERKQRAA"},{"id":"SEQ_09363","a":"Q96C57","g":"CUSTOS","d":"Protein CUSTOS","L":262,"m":[{"c":"SS[NS]S[SE][SD][DS][AD]EEφ[ER]RCREAAψ[PS]A","u":21,"sp":"dispersed","x":"mixed","cf":"high","why":"Two strongly conserved 21-residue internal duplications separated by a ~114-aa linker, pairing an N-terminal Ser/Asp/Glu patch (SS[NS]S...) with a highly conserved helical EEφ[ER]RCREAAψ[PS]A core (12 identical plus 3 physicochemically conserved positions).","i":[[13,33,"SSNSSSDAEELERCREAAMPA"],[148,168,"SSSSEDSDEEWRRCREAAVSA"]]}],"s":"MAAPSGTVSDSESSNSSSDAEELERCREAAMPAWGLEQRPHVAGKPRAGAANSQLSTSQPSLRHKVNEHEQDGNELQTTPEFRAHVAKKLGALLDSFITISEAAKEPAKAKVQKVALEDDGFRLFFTSVPGGREKEESPQPRRKRQPSSSSEDSDEEWRRCREAAVSASDILQESAIHSPGTVEKEAKKKRKLKKKAKKVASVDSAVAATTPTSMATVQKQKSGELNGDQVSLGTKKKKKAKKASETSPFPPAKSATAIPAN"},{"id":"SEQ_09373","a":"Q8N2S1","g":"LTBP4","d":"Latent-transforming growth factor beta-binding protein 4","L":1624,"m":[{"c":"xxxxC(x){3,9}C(x){4,5}C(x){5,8}C(x){1,3}C(x){8,13}C","u":"32-44","sp":"dispersed","x":"structured_like","cf":"high","why":"Twenty 6-cysteine structured repeats (32-44 aa) sharing a strictly conserved C1-C6 disulfide spacing, where 17 copies carry a conserved N-terminal D[IVN][DN]EC acidic leader and 19 copies preserve a Gx[FY]xC4 motif plus a P/G-G-[FYH] turn after C5. Eighteen copies occur in three head-to-tail tandem arrays (a 14-copy central array and two 2-copy C-terminal pairs separated by 1-2 aa gaps) while two copies occur as dispersed N-terminal singletons.","i":[[149,180,"APVLCPLICHNGGVCVKPDRCLCPPDFAGKFC"],[357,396,"DVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC"],[545,585,"SSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRC"],[587,627,"DVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAEC"],[629,669,"DVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASC"],[671,707,"DVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSAC"],[710,750,"DVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPC"],[752,792,"DVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSEC"],[794,832,"DVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRC"],[834,876,"DVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPC"],[878,918,"DVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASC"],[920,959,"DVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASC"],[961,1003,"DVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTC"],[1005,1047,"DVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGC"],[1049,1089,"DVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHC"],[1091,1132,"DVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRC"],[1253,1294,"DVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLEC"],[1296,1336,"DNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRC"],[1533,1572,"EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMAC"],[1574,1617,"DINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC"]]},{"c":"CΩ(x){7,8}C(x){12,13}CC(x){3,4}Gx[AG]WG(x){2,3}C(x){2,4}C[PS](x){10,15}C","u":"51-56","sp":"dispersed","x":"structured_like","cf":"high","why":"Four dispersed 51-56 aa cysteine-rich structured domains anchored by an N-terminal C-aromatic dyad, a conserved central CC/CCC cluster followed immediately by an invariant Gx[AG]WG tryptophan motif, and three C-terminal cysteines.","i":[[289,344,"CFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPC"],[409,459,"CFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREIC"],[1183,1235,"CYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLC"],[1351,1402,"CWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALCPAQDSDDFEALC"]]}],"s":"MPRPGTSGRRPLLLVLLLPLFAAATSAASPSPSPSQVVEVPGVPSRPASVAVCRCCPGQTSRRSRCIRAFCRVRSCQPKKCAGPQRCLNPVPAVPSPSPSVRKRQVSLNWQPLTLQEARALLKRRRPRGPGGRGLLRRRPPQRAPAGKAPVLCPLICHNGGVCVKPDRCLCPPDFAGKFCQLHSSGARPPAPAVPGLTRSVYTMPLANHRDDEHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAARAEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALCPAQDSDDFEALCNVLRPPAYSPPRPGGFGLPYEYGPDLGPPYQGLPYGPELYPPPALPYDPYPPPPGPFARREAPYGAPRFDMPDFEDDGGPYGESEAPAPPGPGTRWPYRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCAPARPRA"},{"id":"SEQ_09377","a":"Q8IVE3","g":"PLEKHH2","d":"Pleckstrin homology domain-containing family H member 2","L":1493,"m":[{"c":"G(x){0,1}LL(x){1,4}KVK(x){2,4}KR[RV]WxxLxG[GK][ET]LφYΩ+Sx[SE]D(x){2,4}PxGxI[EK]L(x){13,41}Tφ[QL]L(x){2,5}EKxTΩ(x){1,3}LT(x){8,12}EΩxxψψxxψL","u":"89-122","sp":"dispersed","x":"structured_like","cf":"high","why":"Internal duplication of two structured 89-122 aa domains (residues 708-796 and 816-937, separated by a 19-aa linker) sharing conserved multi-segment architecture: N-terminal G(x){0,1}LL..KVK..KR[RV], an ungapped 17-aa WxxLxG[GK][ET]LφYΩ+Sx[SE]D core, PxGxI[EK]L, Tφ[QL]L..EKxTΩ(x){1,3}LT across a variable loop insertion, and a C-terminal amphipathic EΩxxψψxxψL helix.","i":[[708,796,"GYLLKMSGKVKSWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGDNKQTVQLTTEKHTYYLTADSPNILEEWIKVLQNVL"],[816,937,"GLLTKVKHGYSKRVWCTLIGKTLYYFRSQEDKFPLGQIKLWEAKVEEVDRSCDSDEDYEASGRSLLSTHYTIVIHPKDQGPTYLLIGSKHEKDTWLYHLTVAAGSNNVNVGSEFEQLVCKLL"]]}],"s":"MAELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQQVQVMEDKLKAANIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQEAKIIEEKAAKIKEWVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQGKKSSTVSTLKLSEGQRLSSLTFGCFLSRARSPPQVVKSEEMSKISSKEPEFTEGKDMEEMEIPEKSVDNQVLENNRGQRTLHQTPCGSEQNRKTRTSFATDGGISQNSGAPVSDWSSDEEDGSKGRSKSRCTSTLSSHTSEEGVQCSRMGSEMYLTASDDSSSIFEEETFGIKRPEHKKLYSWQQEAQWKALNSPLGKGNSELSKKEQDSSSDELNKKFQSQRLDYSSSSSEANTPSPILTPALMPKHPNSLSGKGTQLVPSSHLPPPKLRIPNVFSISVALAKRHLSQPQLSSDRMFGTNRNAISMIRPLRPQETDLDLVDGDSTEVLENMDTSCDDGLFSYDSLDSPNSDDQEHCDSAKKVAYSKPPTPPLHRFPSWESRIYAVAKSGIRMSEAFNMESVNKNSAATLSYTTSGLYTSLIYKNMTTPVYTTLKGKATQISSSPFLDDSSGSEEEDSSRSSSRTSESDSRSRSGPGSPRAMKRGVSLSSVASESDYAIPPDAYSTDTEYSQPEQKLPKTCSSSSDNGKNEPLEKSGYLLKMSGKVKSWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGDNKQTVQLTTEKHTYYLTADSPNILEEWIKVLQNVLRVQAANPLSLQPEGKPTMKGLLTKVKHGYSKRVWCTLIGKTLYYFRSQEDKFPLGQIKLWEAKVEEVDRSCDSDEDYEASGRSLLSTHYTIVIHPKDQGPTYLLIGSKHEKDTWLYHLTVAAGSNNVNVGSEFEQLVCKLLNIDGEPSSQIWRHPTLCHSKEGIISPLTTLPSEALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQICLTHPELQNEICCQLIKQTRRRQPQNQPGPLQGWQLLALCVGLFLPHHPFLWLLRLHLKRNADSRTEFGKYAIYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHSLPFSIPVHFMNGIYQVVGFDASTTVEEFLNTLNQDTGMRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKWEQASKEQQPGKCEGTRTVRLTYKNRLYFSVQARGETDREKLLLMYQTNDQIINGLFPLNKDLALEMAALLSQVEIGDFERPFSTPAGHVTNQCKVNQTLKQVIEKFYPKRYRDGCSEEQLRQLCQRLSTRWMALRGHSAADCVRIYLTVARKWPFFGAKLFLAKPITPSSLGSTFLWLAVHEDGLSLLEYNSMRLIVSYVYKSLMTFGGYQDDFMVVINNTHSKDKPTEKLLFAMAKPKILEITLLIASYINNFHQQKAAFHHLSAPALLSAQTRGPQARMMGSQPLLSSSRPTKGPTLL"},{"id":"SEQ_09394","a":"Q6AI08","g":"HEATR6","d":"HEAT repeat-containing protein 6","L":1181,"m":[{"c":"xxxxxxxxψxxxφxx(x){4,8}[VTC]xxxxxxx[LMS][GAS][NVA]xxxxxxx","u":"37-41","sp":"dispersed","x":"structured_like","cf":"high","why":"Nine non-overlapping copies of a 37-41 aa alpha-helical pair comprising an amphipathic first helix with conserved hydrophobic core positions (ψ, φ), a 4-8 aa turn, and a second helix anchored by N-terminal [VTC] (predominantly VR/VK) and a central [LMS][GAS][NVA] (predominantly LGN/MAN/MGN) motif distributed across three structured clusters.","i":[[159,198,"PELLGNTGLLMKLSDLAQSDPEVRRAAVHCMANLCLSVPG"],[515,552,"SIRELHRCLLLALVAESSSQTVTQIIKCLANLVSNAPY"],[555,595,"LKLSLLTKVWNQIKPYIRHKDVNVRVSSLTLLGAIVSTHAP"],[810,847,"DRQMLCITVLLGLNDSKNRLVKAATSRALGVYVLFPCL"],[853,889,"FVADAANAILMSLEDKSLNVRAKAAWSLGNLTDTLIV"],[902,941,"FSGLLLLKMLRSAIEASKDKDKVKSNAVRALGNLLHFLQP"],[952,989,"IIEESIQALISTVLTEAAMKVRWNACYAMGNVFKNPAL"],[996,1033,"WTSQAYNALTSVVTSCKNFKVRIRSAAALSVPGKREQY"],[1068,1107,"LRTQICQALIHLLSLASASDLPCMKETLELSGNMVQSYIL"]]}],"s":"MAAVQVVGSWPSVQPREAPREAIPERGNGFRLLSARLCALRPDDSSSARTEIHLLFDQLISENYSEGSGVAPEDVSALLVQACRLVPLNQNHLVSKVSQLIHHLLNRLQVIVDEQHLDFLLAYTISAIHQCSSWTHREILQALAALVYCNGSKCQKYLPELLGNTGLLMKLSDLAQSDPEVRRAAVHCMANLCLSVPGQPYLEEPYQNVCFQAFLTILQSPKSSDMDDITFCMLLQNALKGIQSLLNGGRMKLTQTDELGALLAVLKKFMFHGLPGLNIEMPTVLYPTPLPQYDGRTPIKPQQSESSASRPTLNKKKKSKVKPKKIQQGEEEEKESSGEIEAAPVTGTGRVNLHEGNTWCPSSLGVQSLPLDGSGAAEKDGVSSSFSSSSWKRVSSSESDFSDAEGGMQSKMRSYQAKVRQGALVCFLSTIKSIEKKVLYGYWSAFIPDTPELGSPQSVSLMTLTLKDPSPKTRACALQVLSAILEGSKQFLSVAEDTSDHRRAFTPFSVMIACSIRELHRCLLLALVAESSSQTVTQIIKCLANLVSNAPYDRLKLSLLTKVWNQIKPYIRHKDVNVRVSSLTLLGAIVSTHAPLPEVQLLLQQPCSSGLGNSNSATPHLSPPDWWKKAPAGPSLEETSVSSPKGSSEPCWLIRLCISIVVLPKEDSCSGSDAGSAAGSTYEPSPMRLEALQVLTLLARGYFSMTQAYLMELGEVICKCMGEADPSIQLHGAKLLEELGTGLIQQYKPDSTAAPDQRAPVFLVVMFWTMMLNGPLPRALQNSEHPTLQASACDALSSILPEAFSNLPNDRQMLCITVLLGLNDSKNRLVKAATSRALGVYVLFPCLRQDVIFVADAANAILMSLEDKSLNVRAKAAWSLGNLTDTLIVNMETPDPSFQEEFSGLLLLKMLRSAIEASKDKDKVKSNAVRALGNLLHFLQPSHIEKPTFAEIIEESIQALISTVLTEAAMKVRWNACYAMGNVFKNPALPLGTAPWTSQAYNALTSVVTSCKNFKVRIRSAAALSVPGKREQYGSVDQYARIWNALVTALQKSEDTIDFLEFKYCVSLRTQICQALIHLLSLASASDLPCMKETLELSGNMVQSYILQFLKSGAEGDDTGAPHSPQERDQMVRMALKHMGSIQAPTGDTARRAIMGFLEEILAVCFDSSGSQGALPGLTNQ"},{"id":"SEQ_09396","a":"P10070","g":"GLI2","d":"Transcription activator GLI2","L":1586,"m":[{"c":"[YFH](x){1,3}CxxxxCo+(x){1,4}[YF]xxxxx[LR]xxH(x){3,6}H","u":"25-30","sp":"periodic","x":"structured_like","cf":"high","why":"Five periodic C2H2-type repeats (residues 435-587) anchored by an N-terminal [YFH], invariant C-x4-C and H-x(3-6)-H pairs, a conserved polar-basic (o+) dyad after the second cysteine, and a conserved [YF] aromatic 8 residues before the first histidine, separated by exact 5-residue (GEKKE/TGEKP/SNEKP) linkers.","i":[[435,464,"YETNCHWEDCTKEYDTQEQLVHHINNEHIH"],[470,497,"FVCRWQACTREQKPFKAQYMLVVHMRRH"],[503,527,"HKCTFEGCSKAYSRLENLKTHLRSH"],[533,558,"YVCEHEGCNKAFSNASDRAKHQNRTH"],[564,589,"YICKIPGCTKRYTDPSSLRKHVKTVH"]]},{"c":"SRRSS[GE][IA]S[PQ]","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three highly conserved 9-residue motifs dispersed within a central Ser/Pro/Gly-rich disordered region (residues 820-870, separated by 3- and 21-aa linkers and flanked upstream by a degenerate ERRDSSTST site), sharing six invariant positions (SRRSSxxSx) and tightly constrained [GE][IA] and [PQ] choices.","i":[[820,828,"SRRSSGISP"],[832,840,"SRRSSEASP"],[863,871,"SRRSSEASQ"]]}],"s":"METSASATASEKQEAKSGILEAAGFPDPGKKASPLVVAAAAAAAVAAQGVPQHLLPPFHAPLPIDMRHQEGRYHYEPHSVHGVHGPPALSGSPVISDISLIRLSPHPAGPGESPFNAPHPYVNPHMEHYLRSVHSSPTLSMISAARGLSPADVAQEHLKERGLFGLPAPGTTPSDYYHQMTLVAGHPAPYGDLLMQSGGAASAPHLHDYLNPVDVSRFSSPRVTPRLSRKRALSISPLSDASLDLQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHPINPVAYQQILSQQRGLGSAFGHTPPLIQPSPTFLAQQPMALTSINATPTQLSSSSNCLSDTNQNKQSSESAVSSTVNPVAIHKRSKVKTEPEGLRPASPLALTQGQVSGHGSCGCALPLSQEQLADLKEDLDRDDCKQEAEVVIYETNCHWEDCTKEYDTQEQLVHHINNEHIHGEKKEFVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRNDVHLRTPLLKENGDSEAGTEPGGPESTEASSTSQAVEDCLHVRAIKTESSGLCQSSPGAQSSCSSEPSPLGSAPNNDSGVEMPGTGPGSLGDLTALDDTPPGADTSALAAPSAGGLQLRKHMTTMHRFEQLKKEKLKSLKDSCSWAGPTPHTRNTKLPPLPGSGSILENFSGSGGGGPAGLLPNPRLSELSASEVTMLSQLQERRDSSTSTVSSAYTVSRRSSGISPYFSSRRSSEASPLGAGRPHNASSADSYDPISTDASRRSSEASQCSGGSGLLNLTPAQQYSLRAKYAAATGGPPPTPLPGLERMSLRTRLALLDAPERTLPAGCPRPLGPRRGSDGPTYGHGHAGAAPAFPHEAPGGGARRASDPVRRPDALSLPRVQRFHSTHNVNPGPLPPCADRRGLRLQSHPSTDGGLARGAYSPRPPSISENVAMEAVAAGVDGAGPEADLGLPEDDLVLPDDVVQYIKAHASGALDEGTGQVYPTESTGFSDNPRLPSPGLHGQRRMVAADSNVGPSAPMLGGCQLGFGAPSSLNKNNMPVQWNEVSSGTVDALASQVKPPPFPQGNLAVVQQKPAFGQYPGYSPQGLQASPGGLDSTQPHLQPRSGAPSQGIPRVNYMQQLRQPVAGSQCPGMTTTMSPHACYGQVHPQLSPSTISGALNQFPQSCSNMPAKPGHLGHPQQTEVAPDPTTMGNRHRELGVPDSALAGVPPPHPVQSYPQQSHHLAASMSQEGYHQVPSLLPARQPGFMEPQTGPMGVATAGFGLVQPRPPLEPSPTGRHRGVRAVQQQLAYARATGHAMAAMPSSQETAEAVPKGAMGNMGSVPPQPPPQDAGGAPDHSMLYYYGQIHMYEQDGGLENLGSCQVMRSQPPQPQACQDSIQPQPLPSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLTSLAEESKFLNMMT"},{"id":"SEQ_09398","a":"O60291","g":"MGRN1","d":"E3 ubiquitin-protein ligase MGRN1","L":552,"m":[{"c":"[LV]x[EQ][SD]SSP[EQ]","u":8,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three closely spaced 8-aa copies (separated by 6- and 10-aa linkers) in the C-terminal disordered tail share an invariant SSP core anchored by an N-terminal aliphatic [LV] position and flanking [EQ]/[SD] residues (with an additional degenerate LRSPSSPI site 25 aa upstream).","i":[[487,494,"LRESSSPE"],[501,508,"VDESSSPQ"],[519,526,"VLQDSSPE"]]}],"s":"MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSLEFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKKSKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPLGGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPALGPDSCSVGIDE"},{"id":"SEQ_09430","a":"Q15061","g":"WDR43","d":"WD repeat-containing protein 43","L":677,"m":[{"c":"(x){8,14}[VTC](x){10,35}φφ(x){5,10}ψxxΩ","u":"33-59","sp":"periodic","x":"structured_like","cf":"high","why":"Seven structured N-terminal repeats of 33-59 aa separated by short 3-11 aa linkers, each anchored by a conserved [VTC] residue, a core hydrophobic doublet (φφ), and a C-terminal ψxxΩ motif terminating in an invariant aromatic residue (W/Y/F) across variable internal loops.","i":[[9,41,"CDPLAPAGVPCAFSPHSQAYFALASTDGHLRVW"],[51,109,"EYVPSAHLSGTCTCLAWAPARLQAKESPQRKKRKSEAVGMSNQTDLLALGTAVGSILLY"],[117,153,"HSKLISGGHDNRVNCIQWHQDSGCLYSCSDDKHIVEW"],[157,193,"TCKVKCKWKGDNSSVSSLCISPDGKMLLSAGRTIKLW"],[201,249,"YRHFTGHATPVSSLMFTTIRPPNESQPFDGITGLYFLSGAVHDRLLNVW"],[261,299,"VMSFTVTDEPVYIDLTLSENKEEPVKLAVVCRDGQVHLF"],[305,351,"GYCKKPLTSNCTIQIATPGKGKKSTPKPIPILAAGFCSDKMSLLLVY"]]}],"s":"MAAGGGGSCDPLAPAGVPCAFSPHSQAYFALASTDGHLRVWETANNRLHQEYVPSAHLSGTCTCLAWAPARLQAKESPQRKKRKSEAVGMSNQTDLLALGTAVGSILLYSTVKGELHSKLISGGHDNRVNCIQWHQDSGCLYSCSDDKHIVEWNVQTCKVKCKWKGDNSSVSSLCISPDGKMLLSAGRTIKLWVLETKEVYRHFTGHATPVSSLMFTTIRPPNESQPFDGITGLYFLSGAVHDRLLNVWQVRSENKEKSAVMSFTVTDEPVYIDLTLSENKEEPVKLAVVCRDGQVHLFEHILNGYCKKPLTSNCTIQIATPGKGKKSTPKPIPILAAGFCSDKMSLLLVYGSWFQPTIERVALNSREPHMCLVRDISNCWAPKVETAITKVRTPVMNSEAKVLVPGIPGHHAAIKPAPPQTEQVESKRKSGGNEVSIEERLGAMDIDTHKKGKEDLQTNSFPVLLTQGLESNDFEMLNKVLQTRNVNLIKKTVLRMPLHTIIPLLQELTKRLQGHPNSAVLMVQWLKCVLTVHASYLSTLPDLVPQLGTLYQLMESRVKTFQKLSHLHGKLILLITQVTASEKTKGATSPGQKAKLVYEEESSEEESDDEIADKDSEDNWDEDEEESESEKDEDVEEEDEDAEGKDEENGEDRDTASEKELNGDSDLDPENESEEE"},{"id":"SEQ_09433","a":"O60504","g":"SORBS3","d":"Vinexin","L":671,"m":[{"c":"φ[RV]φxΩxΩxxxxxxELx[LF][QR][KE]G-xψxψxxx[VC][DN]x[NG]Wφ[EV]Gx(x){3,5}+xG[IT]FP[AG][NS]YVx[VP]x","u":"53-55","sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed 53-55 aa globular repeats in the C-terminal half (separated by 21 aa and 103 aa linkers) anchored by an N-terminal ΩxΩ dyad, central ELx[LF]..G-xψxψ and Wφ[EV]G core motifs, a minor 4-6 aa loop ending in a basic residue, and a diagnostic C-terminal G[IT]FP[AG][NS]YV signature.","i":[[385,437,"ARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVL"],[459,513,"AVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVS"],[617,671,"YRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV"]]}],"s":"MQGPPRSLRAGLSLDDFIPGHLQSHIGSSSRGTRVPVIRNGGSNTLNFQFHDPAPRTVCNGGYTPRRDASQHPDPAWYQTWPGPGSKPSASTKIPASQHTQNWSATWTKDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHRKMPDLQLDWTFEEPPRDPRHLGAQQRPAHRPGPATSSSGRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV"},{"id":"SEQ_09468","a":"Q9H992","g":"MARCHF7","d":"E3 ubiquitin-protein ligase MARCHF7","L":704,"m":[{"c":"[SQ][AEG]GRN[TV]G","u":7,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed copies in the S/R/P/Q-enriched disordered N-terminal region share an invariant GRNxG core anchored by G, R, N, and G, preceded by polar [SQ] and small/acidic [AEG] positions and conserving [TV] at position 6.","i":[[102,108,"SAGRNVG"],[377,383,"SEGRNTG"],[468,474,"QGGRNTG"]]}],"s":"MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASASPFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWRHSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSYSQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQPGFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSSQDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSLSHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSRSHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILPGSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLLLEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEAVTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGNTNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA"},{"id":"SEQ_09490","a":"Q7Z2W4","g":"ZC3HAV1","d":"Zinc finger CCCH-type antiviral protein 1","L":902,"m":[{"c":"C(x){2,4}PC[DS]xLHψCxxxxxGxC(x){4,9}CxxSH(x){5,8}KVLxxxxxxGLNx-xψxxψ","u":"54-60","sp":"dispersed","x":"structured_like","cf":"high","why":"Two-copy duplicated cysteine/histidine-rich structured domain (separated by a 30-aa linker) sharing 17 invariant positions including a conserved Cx(2,4)PCx2LHψCx5GxCx(4,9)Cx2SH core and a C-terminal KVLx6GLNx-xψxxψ segment.","i":[[78,137,"CQRPCDNLHLCKLNLLGRCNYSQSERNLCKYSHEVLSEENFKVLKNHELSGLNKEELAVL"],[162,215,"CNQQPPCSRLHICDHFTRGNCRFPNCLRSHNLMDRKVLAIMREHGLNPDVVQNI"]]}],"s":"MADPEVCCFITKILCAHGGRMALDALLQEIALSEPQLCEVLQVAGPDRFVVLETGGEAGITRSVVATTRARVCRRKYCQRPCDNLHLCKLNLLGRCNYSQSERNLCKYSHEVLSEENFKVLKNHELSGLNKEELAVLLLQSDPFFMPEICKSYKGEGRQQICNQQPPCSRLHICDHFTRGNCRFPNCLRSHNLMDRKVLAIMREHGLNPDVVQNIQDICNSKHMQKNPPGPRAPSSHRRNMAYRARSKSRDRFFQGSQEFLASASASAERSCTPSPDQISHRASLEDAPVDDLTRKFTYLGSQDRARPPSGSSKATDLGGTSQAGTSQRFLENGSQEDLLHGNPGSTYLASNSTSAPNWKSLTSWTNDQGARRKTVFSPTLPAARSSLGSLQTPEAVTTRKGTGLLSSDYRIINGKSGTQDIQPGPLFNNNADGVATDITSTRSLNYKSTSSGHREISSPRIQDAGPASRDVQATGRIADDADPRVALVNDSLSDVTSTTSSRVDDHDSEEICLDHLCKGCPLNGSCSKVHFHLPYRWQMLIGKTWTDFEHMETIEKGYCNPGIHLCSVGSYTINFRVMSCDSFPIRRLSTPSSVTKPANSVFTTKWIWYWKNESGTWIQYGEEKDKRKNSNVDSSYLESLYQSCPRGVVPFQAGSRNYELSFQGMIQTNIASKTQKDVIRRPTFVPQWYVQQMKRGPDHQPAKTSSVSLTATFRPQEDFCFLSSKKYKLSEIHHLHPEYVRVSEHFKASMKNFKIEKIKKIENSELLDKFTWKKSQMKEEGKLLFYATSRAYVESICSNNFDSFLHETHENKYGKGIYFAKDAIYSHKNCPYDAKNVVMFVAQVLVGKFTEGNITYTSPPPQFDSCVDTRSNPSVFVIFQKDQVYPQYVIEYTEDKACVIS"},{"id":"SEQ_09492","a":"O14979","g":"HNRNPDL","d":"Heterogeneous nuclear ribonucleoprotein D-like","L":420,"m":[{"c":"KψFψGGLSxDTSxxxψxEYφxxFGEψxxxxψxxDxxTxxxRGF[GC]FψxΩxDxxxVxKψLEx+xHxψxxxxx-xKxA","u":75,"sp":"dispersed","x":"structured_like","cf":"high","why":"Ungapped 75-aa duplicated globular domain pair separated by a 10-aa linker, anchored by conserved KψFψGGLSxDTS, EYφxxFGEψ, RGF[GC]FψxΩxD, and VxKψLEx+xHxψ motifs; flanking poly-Q, RG-rich, and GY/NY-rich disordered tracts are unanchored compositional bias.","i":[[149,223,"KMFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAASVDKVLELKEHKLDGKLIDPKRA"],[234,308,"KVFVGGLSPDTSEEQIKEYFGAFGEIENIELPMDTKTNERRGFCFITYTDEEPVKKLLESRYHQIGSGKCEIKVA"]]}],"s":"MEVPPRLSHVPPPLFPSAPATLASRSLSHWRPRPPRQLAPLLPSLAPSSARQGARRAQRHVTAQQPSRLAGGAAIKGGRRRRPDLFRRHFKSSSIQRSAAAAAATRTARQHPPADSSVTMEDMNEYSNIEEFAEGSKINASKNQQDDGKMFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAASVDKVLELKEHKLDGKLIDPKRAKALKGKEPPKKVFVGGLSPDTSEEQIKEYFGAFGEIENIELPMDTKTNERRGFCFITYTDEEPVKKLLESRYHQIGSGKCEIKVAQPKEVYRQQQQQQKGGRGAAAGGRGGTRGRGRGQGQNWNQGFNNYYDQGYGNYNSAYGGDQNYSGYGGYDYTGYNYGNYGYGQGYADYSGQQSTYGKASRGGGNHQNNYQPY"},{"id":"SEQ_09529","a":"A6NM11","g":"LRRC37A2","d":"Leucine-rich repeat-containing protein 37A2","L":1700,"m":[{"c":"xx[TS][VT][QK][PL][LPA]D[LV][GEQ][LFV][TA]I[TIA]x[EK][PS]x[TNA]E[VT]xxSx","u":25,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Seven dispersed 25-aa repeats across the central Pro/Thr/Ser-rich region (residues 296-767) anchored by invariant D8, I13, E20, and S24 alongside tightly conserved [TS][VT][QK][PL], [LV], [LFV], and [PS] positions.","i":[[296,320,"NITVKPADVEVTITSEPTNETESSQ"],[409,433,"SVSVKPPDVQLTIAAEPSAEVGTSL"],[541,565,"QATVQPLDLGFTITPESKTEVELSP"],[605,629,"SVTVQLLDLGLTITPEPTTEVGHST"],[660,684,"RATVQPLDLGFTITPKSMTEVEPST"],[715,739,"QATVQPLDLELTITTKPTTEVKPSP"],[743,767,"ETSTQPPDLGLAIIPEPTTETRHST"]]},{"c":"x[LFT]xx[LI][NDI]φxx[NT]xψ(x){12,15}","u":"24-27","sp":"tandem","x":"structured_like","cf":"high","why":"Six contiguous 24-27 aa leucine-rich repeat units (residues 866-1012) defined by a conserved xLxxLxLxxNxψ hydrophobic/asparagine ladder and a variable 12-15 aa C-terminal return segment.","i":[[866,889,"TFTILNFQGNYISYIDGNVWKAYS"],[890,913,"WTEKLILRENNLTELHKDSFEGLL"],[914,937,"SLQYLDLSCNKIQSIERHTFEPLP"],[938,964,"FLKFINLSCNVITELSFGTFQAWHGMQ"],[965,988,"FLHKLILNHNPLTTVEDPYLFKLP"],[989,1012,"ALKYLDMGTTLVPLTTLKNILMMT"]]},{"c":"[QH]QE[AT][PSA]x[QEL]xP[EQV]","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Eight non-overlapping 10-aa repeats within the N-terminal disordered region (residues 240-526, interleaved between the first three 25-aa repeats) featuring invariant Q2, E3, and P9 anchors plus strictly conserved [AT]4 and [PSA]5.","i":[[239,248,"QQEAPAQLPQ"],[258,267,"QQEAPALPPE"],[322,331,"QQETPIQFPE"],[339,348,"QQEAPIEPPV"],[379,388,"QQETPGQPPE"],[475,484,"QQETSFQSPE"],[495,504,"QQEAAAEHPQ"],[515,524,"HQEAPAQTPE"]]}],"s":"MSSAQCPALVCVMSRLRFWGPWPLLMWQLLWLLVKEAQPLEWVKDPLQLTSNPLGPPDSWSSHSSHFPRESPHAPTLPADPWDFDHLGPSASSEMPAPPQESTENLVPFLDTWDSAGEQPLEPEQFLASQQDLKDKLSPQERLPVSPKKLKKDPAQRWSLAEIIGITRQLSTPQSQKQTLQNEYSSTDTPYPGSLPPELRVKSDEPPGPSEQVGPSQFHLEPETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPSSMQQEAPALPPESSMESLTLPNHEVSVQPPGEDQAYYHLPNITVKPADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHELSISEQQQPVQPSESPREVESSPTQQETPGQPPEHHEVTVSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEVGTSLVHQEATTRLSGSGNDVEPPAIQHGGPPLLPESSEEAGPLAVQQETSFQSPEPINNENPSPTQQEAAAEHPQTAEEGESSLTHQEAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLGFTITPESKTEVELSPTMKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHSTPPKRTIVSPKHPEVTLPHPDQVQTQHSHLTRATVQPLDLGFTITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSPTTEETSTQPPDLGLAIIPEPTTETRHSTALEKTTAPRPDRVQTLHRSLTEVTGPPTELEPAQDSLVQSESYTQNKALTAPEEHKASTSTNICELCTCGDEMLSCIDLNPEQRLRQVPVPEPNTHNGTFTILNFQGNYISYIDGNVWKAYSWTEKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVITELSFGTFQAWHGMQFLHKLILNHNPLTTVEDPYLFKLPALKYLDMGTTLVPLTTLKNILMMTVELEKLILPSHMACCLCQFKNSIEAVCKTVKLHCNSACLTNTTHCPEEASVGNPEGAFMKVLQARKNYTSTELIVEPEEPSDSSGINLSGFGSEQLDTNDESDFISTLSYILPYFSAVNLDVKSLLLPFIKLPTTGNSLAKIQTVGQNRQRVKRVLMGPRSIQKRHFKEVGRQSIRREQGAQASVENAAEEKRLGSPAPREVEQPHTQQGPEKLAGNAVYTKPSFTQEHKAAVSVLKPFSKGAPSTSSPAKALPQVRDRWKDLTHAISILESAKARVTNTKTSKPIVHARKKYRFHKTRSHVTHRTPKVKKSPKVRKKSYLSRLMLANRLPFSAAKSLINSPSQGAFSSLGDLSPQENPFLEVSAPSEHFIENNNTKHTTARNAFEENDFMENTNMPEGTISENTNYNHPHEADSAGTAFNLGPTVKQTETKWEYNNVGTDLSPEPKSFNYPLLSSPGDQFEIQLTQQLQSLIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLISRTGHLMKLLSGQQEVKASKIEWDTDQWKIENYINESTEAQSEQKEKSLELKKEVPGYGYTDKLILALIVTGILTILIILFCLIVICCHRRSLQEDEEGFSRGIFRFLPWRGCSSRRESQDGLSSFGQPLWFKDMYKPLSATRINNHAWKLHKKSSNEDKILNRDPGDSEAPTEEEESEALP"},{"id":"SEQ_09531","a":"P98169","g":"ZXDB","d":"Zinc finger X-linked protein ZXDB","L":803,"m":[{"c":"Ω(x){1,3}C(x){2,4}Cxxx[FY]xxxxx[LM]xxH(x){3,4}H","u":"23-28","sp":"periodic","x":"structured_like","cf":"high","why":"Ten periodic 23-28 aa repeats separated by short 5-8 aa linkers, anchored by an N-terminal aromatic residue, invariant Cys2 and His2 pairs, and conserved internal [FY] and [LM] hydrophobic core positions.","i":[[271,295,"YLCPEAQCGQTFAKKHQLKVHLLTH"],[304,328,"FKCPLGGCGWTFTTSYKLKRHLQSH"],[334,358,"FGCPAEGCGKSFTTVYNLKAHMKGH"],[364,386,"FKCEVCEESFPTQAKLSAHQRSH"],[393,417,"YQCAFSGCKKTFITVSALFSHNRAH"],[424,448,"FSCSFPGCSKQYDKACRLKIHLRSH"],[454,478,"FLCDFDGCGWNFTSMSKLLRHKRKH"],[484,508,"FMCPVEGCGKSFTRAEHLKGHSITH"],[514,538,"FVCPVAGCCARFSARSSLYIHSKKH"],[545,572,"WKSRCPISSCNKLFTSKHSMKTHMVKRH"]]},{"c":"[AS]LTPSSxL","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three copies of an 8-residue motif in the C-terminal polar/proline-rich disordered region sharing six invariant residues (LTPSSxL) and a constrained N-terminal [AS] position.","i":[[587,594,"SLTPSSEL"],[723,730,"ALTPSSKL"],[736,743,"ALTPSSTL"]]}],"s":"MEIPKLLPARGTLQGGGGGGIPAGGGRVHRGPDSPAGQVPTRRLLLLRGPQDGGPGRRREEASTASRGPGPSLLAPRTDQPSGGGGGGGDDFFLVLLDPVGGDVETAGSGQAAGPVLREEAEEGPGLQGGESGANPAGPTALGPRCLSAVPTPAPISAPGPAAAFAGTVTIHNQDLLLRFENGVLTLATPPPHAWEPGAAPAQQPGCLIAPQAGFPHAAHPGDCPELPPDLLLAEPAEPAPAPAPEEEAEGPAAALGPRGPLGSGPGVVLYLCPEAQCGQTFAKKHQLKVHLLTHSSSQGQRPFKCPLGGCGWTFTTSYKLKRHLQSHDKLRPFGCPAEGCGKSFTTVYNLKAHMKGHEQENSFKCEVCEESFPTQAKLSAHQRSHFEPERPYQCAFSGCKKTFITVSALFSHNRAHFREQELFSCSFPGCSKQYDKACRLKIHLRSHTGERPFLCDFDGCGWNFTSMSKLLRHKRKHDDDRRFMCPVEGCGKSFTRAEHLKGHSITHLGTKPFVCPVAGCCARFSARSSLYIHSKKHLQDVDTWKSRCPISSCNKLFTSKHSMKTHMVKRHKVGQDLLAQLEAANSLTPSSELTSQRQNDLSDAEIVSLFSDVPDSTSAALLDTALVNSGILTIDVASVSSTLAGHLPANNNNSVGQAVDPPSLMATSDPPQSLDTSLFFGTAATGFQQSSLNMDEVSSVSVGPLGSLDSLAMKNSSPEPQALTPSSKLTVDTDALTPSSTLCENSVSELLTPTKAEWNVHPDSDFFGQEGETQFGFPNAAGNHGSQKETDLITVTGSSFLV"},{"id":"SEQ_09533","a":"O60229","g":"KALRN","d":"Kalirin","L":2986,"m":[{"c":"xFψ[ML]xELψQTEK[AD]YV+DL(x){24,26}[HK]IψFGNI[QH][QE]IYDΩHxxφFLxELEK(x){20}ψYV[TW]YC[KQ]NKPxSxxφψxE(x){21,22}LIKPψQRITKYQLLLK-φL(x){16,19}MxxVPK+[AC]NDxMxxxxLxGF(x){29,30}ERxxFLFExxψψFSxxψ(x){23}ExV-[GN]DPCKFAL(x){44,48}","u":"309-312","sp":"dispersed","x":"structured_like","cf":"high","why":"Large 309-312 aa internal duplication sharing ~38% identity across the full globular span, anchored by highly conserved blocks including Fψ[ML]xELψQTEK[AD]YV+DL, IψFGNI[QH][QE]IYDΩH, LIKPψQRITKYQLLLK-φL, ERxxFLFE, and DPCKFAL.","i":[[1283,1594,"EFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPL"],[1931,2239,"MFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSERVVLQAANADIQQAWVQDINQVLETQRDFLNALQSPI"]]},{"c":"(x){4,7}φ(x){11,14}φxxφ(x){10,25}Ω(x){45,49}φxxφ(x){5,12}","u":"89-113","sp":"periodic","x":"structured_like","cf":"high","why":"Array of nine ~100-aa three-helix bundle repeats across residues 179-1216 featuring conserved N-terminal Trp/hydrophobic anchors, spaced hydrophobic core positions, and strongly conserved internal motifs ([DG]WI / [AM]S[AV]VF) across alternating and adjacent units.","i":[[179,280,"NHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPK"],[295,395,"LHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQ"],[396,508,"LDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVL"],[521,621,"LESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARH"],[622,710,"LEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRS"],[752,864,"VQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKDIDLAAQVQEL"],[873,982,"HELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHYDADAIRECAE"],[983,1083,"KVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRN"],[1112,1216,"ENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTV"]]},{"c":"[KD]LxGGC(x){19,21}[QS]xG[QE][TV]V[EQ]ψL(x){7,9}CLV(x){5,7}SPxxEG[LW]VP[SG]S[AI]L","u":"64-66","sp":"dispersed","x":"structured_like","cf":"high","why":"Duplicated 64-66 aa globular domain positioned C-terminal to each 309-312 aa repeat module, sharing four collinear conserved motifs ([KD]LxGGC, [QS]xG[QE][TV]V[EQ]ψL, CLV, and SPxxEG[LW]VP[SG]S[AI]L).","i":[[1643,1706,"KLSGGCELTVVLQDFSAGHSSELTIQVGQTVELLERPSERPGWCLVRTTERSPPLEGLVPSSAL"],[2316,2381,"DLGGCNGTSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSIL"]]}],"s":"MTDRFWDQWYLWYLRLLRLLDRGSFRNDGLKASDVLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDREVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGDGSSQPDTISIASRTSQNTVDSDKLSGGCELTVVLQDFSAGHSSELTIQVGQTVELLERPSERPGWCLVRTTERSPPLEGLVPSSALCISHSRSSVEMDCFFPLVKDAYSHSSSENGGKSESVANLQAQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSGKADGNIKKQKKVRDGRKSFDLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSSLLAARQASTEVPTAADLVNAIEKLVKNKLSLEGSSYRGSLKDPAGCLNEGMAPPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSERVVLQAANADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERSTAVMRSQPARLPQASPRPYSSVPAGSEKPPKGSSYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKQNDLGGCNGTSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLTKATAAESSDGSIKKSCSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDAAADGATISWKENFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQPHNGSYSKIPLDTSRLACFIERRKHQNDVRPIPNVKSYIVNRVNQGT"},{"id":"SEQ_09540","a":"Q14004","g":"CDK13","d":"Cyclin-dependent kinase 13","L":1512,"m":[{"c":"[SG][PRS]SPYS[RSP]","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five dispersed 7-aa copies in the RS/SP-rich disordered region share an invariant SPYS core flanked by constrained N-terminal [SG][PRS] and C-terminal [RSP] positions (plus a degenerate RSPSYSR variant at residues 370-376).","i":[[347,353,"GSSPYSR"],[358,364,"SPSPYSR"],[383,389,"SPSPYSS"],[395,401,"SRSPYSP"],[411,417,"SRSPYSS"]]},{"c":"+AAEA[AT]","u":6,"sp":"tandem","x":"disordered_like","cf":"high","why":"Four contiguous head-to-tail hexapeptide copies with an invariant +AAEA core (basic R/K at position 1 and acidic E at position 4) and [AT] at position 6.","i":[[460,465,"RAAEAA"],[466,471,"RAAEAA"],[472,477,"KAAEAT"],[478,483,"KAAEAA"]]},{"c":"K[ET][PE]P[KS]AY","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three 7-aa copies clustered within a 24-residue disordered segment (two tandem copies followed by a 3-aa RED linker) anchored by invariant K1, P4, A6, and Y7 positions.","i":[[287,293,"KEPPSAY"],[294,300,"KEPPKAY"],[304,310,"KTEPKAY"]]}],"s":"MPSSSDTALGGGGGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLFLAAPGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRVFSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQLKSQGSSNVAPVKTGPGQHLNHSELAILLNLLQSKTSVNMADFVQVLNIKVNSETQQQLNKINLPAGILATGEKQTDPSTPQQESSKPLGGIQPSSQTIQPKVETDAAQAAVQSAFAVLLTQLIKAQQSKQKDVLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPPDQRPPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKREGGIDYQAGDTYVSTSDYKDNFGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLDNYSTASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPIAVLANSSDPSTGPESTHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHISTSTGRGRGRGLPY"},{"id":"SEQ_09541","a":"Q05682","g":"CALD1","d":"Caldesmon","L":793,"m":[{"c":"[SA][DG]L(x){2,5}[GD]V[RS][NS]xx[NS]xW[EL][KT](x){5,7}SP[TA]","u":"26-27","sp":"dispersed","x":"disordered_like","cf":"high","why":"Three C-terminal copies in a P/S/K/T-rich disordered region anchored by an N-terminal [SA][DG]L motif, an invariant V...W core ([GD]V[RS][NS]xx[NS]xW[EL][KT]), and a C-terminal SP[TA] motif separated by short 3-9 aa linkers.","i":[[700,726,"SDLPVPAEGVRNIKSMWEKGNVFSSPT"],[736,761,"AGLKVGVSSRINEWLTKTPDGNKSPA"],[765,791,"SDLRPGDVSSKRNLWEKQSVDKVTSPT"]]},{"c":"EEEKRAAEERQR[IA]+","u":14,"sp":"tandem","x":"mixed","cf":"high","why":"Four head-to-tail 14-aa copies (three 100% identical) with 12 invariant positions including fixed non-charged AA, Q, and [IA] anchors, representing an exact internal sequence duplication embedded within a broader charged helical rod.","i":[[319,332,"EEEKRAAEERQRIK"],[333,346,"EEEKRAAEERQRIK"],[347,360,"EEEKRAAEERQRIK"],[361,374,"EEEKRAAEERQRAR"]]}],"s":"MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV"},{"id":"SEQ_09542","a":"Q5D862","g":"FLG2","d":"Filaggrin-2","L":2391,"m":[{"c":"[EQK][SP][GE][SF]xxxxR[HQ]x[TI][TI][HY]GQ[TRI][GIA][DEN][TA][TS][RGE]H[SGA][HQY][SYP][GHS][HQY][GE][QKL][ST][TI]Q[TRS]GS[RS][TV][TSA][GR]R[RQ]x[SFT][GS][HQ]S-x[ST]DSE[VG][HYP]SxxS[HQP][TR][HP]x[GSE](x){0,2}[HQ][TIA][HYQ][GTS]Q[AS][GR]S[QHR][HYQ]x","u":"75-77","sp":"tandem","x":"disordered_like","cf":"high","why":"C-terminal half contains 14 contiguous head-to-tail 75-77 aa disordered tandem repeats (plus a partial 40-aa C-terminal copy) anchored by invariant R9, G15-Q16, H23, Q33, G35-S36, R41, S47, D51-S52-E53, S56, S59, Q69, and S72, with a clean 2-residue insertion in four copies.","i":[[1227,1301,"ESGSTVHGRQETTHGQTINTTRHSQSGQGQSTQTGSRVTRRRRSSQSENSDSEVHSKVSHRHSEHIHTQAGSHYP"],[1302,1378,"KSGSTVRRRQGTTHGQRGDTTRHGHSGHGQSTQTGSRTSGRQRFSHSDATDSEVHSGVSHRPHSQEQTHSQAGSQHG"],[1379,1455,"ESESTVHERHETTYGQTGEATGHGHSGHGQSTQRGSRTTGRRGSGHSESSDSEVHSGGSHRPQSQEQTHGQAGSQHG"],[1456,1530,"ESGSTVHGRHGTTHGQTGDTTRHAHYHHGKSTQRGSSTTGRRGSGHSESSDSEVHSGGSHTHSGHTHGQSGSQHG"],[1531,1607,"ESESIIHDRHRITHGQTGDTTRHSYSGHEQTTQTGSRTTGRQRTSHSESTDSEVHSGGSHRPHSREHTYGQAGSQHE"],[1608,1682,"EPEFTVHERHGTTHGQIGDTTGHSHSGHGQSTQRGSRTTGRQRSSHSESSDSEVHSGVSHTHTGHTHGQAGSQHG"],[1683,1757,"QSESIVPERHGTTHGQTGDTTRHAHYHHGLTTQTGSRTTGRRGSGHSEYSDSEGYSGVSHTHSGHTHGQARSQHG"],[1758,1834,"ESESIVHERHGTIHGQTGDTTRHAHSGHGQSTQTGSRTTGRRSSGHSEYSDSEGHSGFSQRPHSRGHTHGQAGSQHG"],[1835,1909,"ESESIVDERHGTTHGQTGDTSGHSQSGHGQSTQSGSSTTGRRRSGHSESSDSEVHSGGSHTHSGHTHSQARSQHG"],[1910,1984,"ESESTVHKRHQTTHGQTGDTTEHGHPSHGQTIQTGSRTTGRRGSGHSEYSDSEGPSGVSHTHSGHTHGQAGSHYP"],[1985,2059,"ESGSSVHERHGTTHGQTADTTRHGHSGHGQSTQRGSRTTGRRASGHSEYSDSEGHSGVSHTHSGHAHGQAGSQHG"],[2060,2134,"ESGSSVHERHGTTHGQTGDTTRHAHSGHGQSTQRGSRTAGRRGSGHSESSDSEVHSGVSHTHSGHTYGQARSQHG"],[2135,2209,"ESGSAIHGRQGTIHGQTGDTTRHGQSGHGQSTQTGSRTTGRQRSSHSESSDSEVHSEASPTHSGHTHSQAGSRHG"],[2210,2284,"QSGSSGHGRQGTTHGQTGDTTRHAHYGYGQSTQRGSRTTGRRGSGHSESSDSEVHSWGSHTHSGHIQGQAGSQQR"]]},{"c":"Q[HY]E[SY]RSx[QH]S[SN]YGQH[GS][SFT]GSSQSSG[YC]GQ[HY][GE]S(x){0,2}[GR][QEP]T[STF][GS]FGQHx[SLP][GS]S[GSD][QN][SYF][ST][GS][FS]GQ[HY][GI]S[GD]S[GD]QS[SAT]GFGQ[HY][GVE][ST]G[ST]G[QK][SY][ST]G[FL][GA]","u":"75-77","sp":"tandem","x":"disordered_like","cf":"high","why":"Central disordered region contains 9 contiguous head-to-tail 75-77 aa higher-order tandem repeats (up to 97% pairwise sequence identity), each composed of six differentiated 11-13 aa Q[HY]-anchored sub-repeats beginning with a signature Q[HY]E[SY]RSx[QH]S[SN]YG dodecamer.","i":[[533,607,"QHESRSRQSSYGQHGSGSSQSSGYGQYGSRETSGFGQHGLGSGQSTGFGQYGSGSGQSSGFGQHGSGSGQSSGFG"],[608,682,"QHESRSGQSSYGQHSSGSSQSSGYGQHGSRQTSGFGQHGSGSSQSTGFGQYGSGSGQSSGFGQHVSGSGQSSGFG"],[683,759,"QHESRSGHSSYGQHGFGSSQSSGYGQHGSSSGQTSGFGQHELSSGQSSSFGQHGSGSGQSSGFGQHGSGSGQSSGFG"],[760,834,"QHESRSGQSSYGQHSSGSSQSSGYGQHGSRQTSGFGQHGSGSSQSTGFGQYGSGSGQSAGFGQHGSGSGQSSGFG"],[835,911,"QHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTSGFGQHRSSSGQYSGFGQHGSGSGQSSGFGQHGTGSGQYSGFG"],[912,988,"QHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTFGFGQHRSGSGQSSGFGQHGSGSGQSSGFGQHESGSGKSSGFG"],[989,1065,"QHESRSSQSNYGQHGSGSSQSSGYGQHGSSSGQTTGFGQHRSSSGQYSGFGQHGSGSDQSSGFGQHGTGSGQSSGFG"],[1066,1142,"QYESRSRQSSYGQHGSGSSQSSGYGQHGSNSGQTSGFGQHRPGSGQSSGFGQYGSGSGQSSGFGQHGSGTGKSSGFA"],[1143,1219,"QHEYRSGQSSYGQHGTGSSQSSGCGQHESGSGPTTSFGQHVSGSDNFSSSGQHISDSGQSTGFGQYGSGSGQSTGLG"]]},{"c":"Q[HC]GS[GSV]SG[QK][ST]SGFG","u":13,"sp":"tandem","x":"disordered_like","cf":"high","why":"Immediately preceding the 9-copy 75-77 aa super-repeat array is a non-overlapping lead-in tandem array of 5 highly conserved 13-aa repeats anchored by fixed Q1, G3-S4, S6-G7, S10-G11-F12-G13.","i":[[468,480,"QHGSSSGKTSGFG"],[481,493,"QHGSGSGQSSGFG"],[494,506,"QCGSGSGQSSGFG"],[507,519,"QHGSVSGQSSGFG"],[520,532,"QHGSVSGQSSGFG"]]}],"s":"MTDLLRSVVTVIDVFYKYTKQDGECGTLSKGELKELLEKELHPVLKNPDDPDTVDVIMHMLDRDHDRRLDFTEFLLMIFKLTMACNKVLSKEYCKASGSKKHRRGHRHQEEESETEEDEEDTPGHKSGYRHSSWSEGEEHGYSSGHSRGTVKCRHGSNSRRLGRQGNLSSSGNQEGSQKRYHRSSCGHSWSGGKDRHGSSSVELRERINKSHISPSRESGEEYESGSGSNSWERKGHGGLSCGLETSGHESNSTQSRIREQKLGSSCSGSGDSGRRSHACGYSNSSGCGRPQNASSSCQSHRFGGQGNQFSYIQSGCQSGIKGGQGHGCVSGGQPSGCGQPESNPCSQSYSQRGYGARENGQPQNCGGQWRTGSSQSSCCGQYGSGGSQSCSNGQHEYGSCGRFSNSSSSNEFSKCDQYGSGSSQSTSFEQHGTGLSQSSGFEQHVCGSGQTCGQHESTSSQSLGYDQHGSSSGKTSGFGQHGSGSGQSSGFGQCGSGSGQSSGFGQHGSVSGQSSGFGQHGSVSGQSSGFGQHESRSRQSSYGQHGSGSSQSSGYGQYGSRETSGFGQHGLGSGQSTGFGQYGSGSGQSSGFGQHGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQSSGYGQHGSRQTSGFGQHGSGSSQSTGFGQYGSGSGQSSGFGQHVSGSGQSSGFGQHESRSGHSSYGQHGFGSSQSSGYGQHGSSSGQTSGFGQHELSSGQSSSFGQHGSGSGQSSGFGQHGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQSSGYGQHGSRQTSGFGQHGSGSSQSTGFGQYGSGSGQSAGFGQHGSGSGQSSGFGQHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTSGFGQHRSSSGQYSGFGQHGSGSGQSSGFGQHGTGSGQYSGFGQHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTFGFGQHRSGSGQSSGFGQHGSGSGQSSGFGQHESGSGKSSGFGQHESRSSQSNYGQHGSGSSQSSGYGQHGSSSGQTTGFGQHRSSSGQYSGFGQHGSGSDQSSGFGQHGTGSGQSSGFGQYESRSRQSSYGQHGSGSSQSSGYGQHGSNSGQTSGFGQHRPGSGQSSGFGQYGSGSGQSSGFGQHGSGTGKSSGFAQHEYRSGQSSYGQHGTGSSQSSGCGQHESGSGPTTSFGQHVSGSDNFSSSGQHISDSGQSTGFGQYGSGSGQSTGLGQGESQQVESGSTVHGRQETTHGQTINTTRHSQSGQGQSTQTGSRVTRRRRSSQSENSDSEVHSKVSHRHSEHIHTQAGSHYPKSGSTVRRRQGTTHGQRGDTTRHGHSGHGQSTQTGSRTSGRQRFSHSDATDSEVHSGVSHRPHSQEQTHSQAGSQHGESESTVHERHETTYGQTGEATGHGHSGHGQSTQRGSRTTGRRGSGHSESSDSEVHSGGSHRPQSQEQTHGQAGSQHGESGSTVHGRHGTTHGQTGDTTRHAHYHHGKSTQRGSSTTGRRGSGHSESSDSEVHSGGSHTHSGHTHGQSGSQHGESESIIHDRHRITHGQTGDTTRHSYSGHEQTTQTGSRTTGRQRTSHSESTDSEVHSGGSHRPHSREHTYGQAGSQHEEPEFTVHERHGTTHGQIGDTTGHSHSGHGQSTQRGSRTTGRQRSSHSESSDSEVHSGVSHTHTGHTHGQAGSQHGQSESIVPERHGTTHGQTGDTTRHAHYHHGLTTQTGSRTTGRRGSGHSEYSDSEGYSGVSHTHSGHTHGQARSQHGESESIVHERHGTIHGQTGDTTRHAHSGHGQSTQTGSRTTGRRSSGHSEYSDSEGHSGFSQRPHSRGHTHGQAGSQHGESESIVDERHGTTHGQTGDTSGHSQSGHGQSTQSGSSTTGRRRSGHSESSDSEVHSGGSHTHSGHTHSQARSQHGESESTVHKRHQTTHGQTGDTTEHGHPSHGQTIQTGSRTTGRRGSGHSEYSDSEGPSGVSHTHSGHTHGQAGSHYPESGSSVHERHGTTHGQTADTTRHGHSGHGQSTQRGSRTTGRRASGHSEYSDSEGHSGVSHTHSGHAHGQAGSQHGESGSSVHERHGTTHGQTGDTTRHAHSGHGQSTQRGSRTAGRRGSGHSESSDSEVHSGVSHTHSGHTYGQARSQHGESGSAIHGRQGTIHGQTGDTTRHGQSGHGQSTQTGSRTTGRQRSSHSESSDSEVHSEASPTHSGHTHSQAGSRHGQSGSSGHGRQGTTHGQTGDTTRHAHYGYGQSTQRGSRTTGRRGSGHSESSDSEVHSWGSHTHSGHIQGQAGSQQRQPGSTVHGRLETTHGQTGDTTRHGHSGYGQSTQTGSRSSRASHFQSHSSERQRHGSSQVWKHGSYGPAEYDYGHTGYGPSGGSRKSISNSHLSWSTDSTANKQLSRH"},{"id":"SEQ_09544","a":"Q6S8J3","g":"POTEE","d":"POTE ankyrin domain family member E","L":1075,"m":[{"c":"LR[NS]KMGKWC[CH][HR]CFPC[CY]R[EG]SGKS[KN]VG[AT]xGD[HY]DDSAφxx","u":37,"sp":"tandem","x":"structured_like","cf":"high","why":"Three head-to-tail 37-aa N-terminal repeats sharing >78% identity with invariant LR, KMGKWC, CFPC, SGKS, VG, GD, and DDSA anchors.","i":[[20,56,"LRSKMGKWCCRCFPCYRESGKSNVGTSGDHDDSAMKT"],[57,93,"LRSKMGKWCHHCFPCCRGSGKSNVGASGDHDDSAMKT"],[94,130,"LRNKMGKWCCHCFPCCRGSGKSKVGAWGDYDDSAFME"]]},{"c":"IC[EQ]LLSDYKEKQMxKφSSENSNPEQ-LKLTSEEESQRφKGSEN[GS]QPEKxSQExEINKDGDREψEx(x){0,5}EMKKHxSoxVGφxENLTNG[AV]TAGNGD[DN]GLIPxRKSRTPEoQQFPDoEoEEYH","u":"117-122","sp":"tandem","x":"disordered_like","cf":"high","why":"Two large tandem repeats separated by a single residue in the central polar/acidic disordered region, conserving 96 of 117 aligned positions (~82% identity) around a 5-residue internal insertion.","i":[[353,469,"ICQLLSDYKEKQMLKISSENSNPEQELKLTSEEESQRFKGSENSQPEKMSQELEINKDGDREVEEEMKKHESNNVGLLENLTNGVTAGNGDNGLIPQRKSRTPENQQFPDNESEEYH"],[471,592,"ICELLSDYKEKQMPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIEEMKKHGSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYH"]]},{"c":"x[GK]xT[APT]L[HIL]x[AG]xxxxxxxx[AV]xφLψxxxx[DNQ]xxxx[DN]x","u":33,"sp":"tandem","x":"structured_like","cf":"high","why":"Five contiguous 33-aa structural repeats anchored by an N-terminal T[APT]L[HIL]x[AG] motif and a second hydrophobic helix core ([AV]xφLψ).","i":[[172,204,"QKRTALHLASANGNSEVVKLLLDRRCQLNVLDN"],[205,237,"KKRTALIKAVQCQEDECALMLLEHGTDPNIPDE"],[238,270,"YGNTTLHYAIYNEDKLMAKALLLYGADIESKNK"],[271,303,"HGLTPLLLGVHEQKQQVVKFLIKKKANLNALDR"],[304,336,"YGRTALILAVCCGSASIVSLLLEQNIDVSSQDL"]]}],"s":"MVVEVDSMPAASSVKKPFGLRSKMGKWCCRCFPCYRESGKSNVGTSGDHDDSAMKTLRSKMGKWCHHCFPCCRGSGKSNVGASGDHDDSAMKTLRNKMGKWCCHCFPCCRGSGKSKVGAWGDYDDSAFMEPRYHVRGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKKDKQKRTALHLASANGNSEVVKLLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQMLKISSENSNPEQELKLTSEEESQRFKGSENSQPEKMSQELEINKDGDREVEEEMKKHESNNVGLLENLTNGVTAGNGDNGLIPQRKSRTPENQQFPDNESEEYHRICELLSDYKEKQMPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIEEMKKHGSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQKQFCEEQNTGILHDEILIHEEKQIEVVEKMNSELSLSCKKEKDVLHENSTLREEIAMLRLELDTMKHQSQLREKKYLEDIESVKKKNDNLLKALQLNELTMDDDTAVLVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRQQGMMGGMHQKESYVGKEAQSKRGILTLKYPMEHGIITNWDDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVPSLYTSGRTTGIVMDSGDGVTHTVPIYEGNALPHATLRLDLAGRELPDYLMKILTERGYRFTTMAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPCFLGMESCGIHETTFNSIMKSDVDIRKDLYTNTVLSGGTTMYPGMAHRMQKEIAALAPSMMKIRIIAPPKRKYSVWVGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF"},{"id":"SEQ_09554","a":"Q8TBC5","g":"ZSCAN18","d":"Zinc finger and SCAN domain-containing protein 18","L":510,"m":[{"c":"xxKxYACxxCxxxFxΩxxxLφEH[HQ]x[ST]Hx","u":28,"sp":"tandem","x":"structured_like","cf":"high","why":"Two head-to-tail 28-aa Cys2His2-pattern repeats sharing 10 identical anchor residues (K, YAC, C, F, L, E, H, H) and conserved aromatic/hydrophobic core positions in exact register.","i":[[409,436,"RGKPYACGECGEAFAWLSHLMEHHSSHG"],[437,464,"GRKRYACQGCWKTFHFSLALAEHQKTHE"]]}],"s":"MLPLEKAFASPRSSPAPPDLPTPGSAAGVQQEEPETIPERTPADLEFSRLRFREFVYQEAAGPHQTLARLHELCRQWLMPEARSKEQMLELLVLEQFLGILPDKVRPWVVAQYPESCKKAASLVEGLADVLEEPGMLLGSPAGSSSILSDGVYERHMDPLLLPGELASPSQALGAGEIPAPSETPWLSPDPLFLEQRRVREAKTEEDGPANTEQKLKSFPEDPQHLGEWGHLDPAEENLKSYRKLLLWGYQLSQPDAASRLDTEELRLVERDPQGSSLPEGGRRQESAGCACEEAAPAGVLPELPTEAPPGDALADPPSGTTEEEEEQPGKAPDPQDPQDAESDSATGSQRQSVIQQPAPDRGTAKLGTKRPHPEDGDGQSLEGVSSSGDSAGLEAGQGPGADEPGLSRGKPYACGECGEAFAWLSHLMEHHSSHGGRKRYACQGCWKTFHFSLALAEHQKTHEKEKSYALGGARGPQPSTREAQAGARAGGPPESVEGEAPPAPPEAQR"},{"id":"SEQ_09558","a":"A8MW92","g":"PHF20L1","d":"PHD finger protein 20-like protein 1","L":1017,"m":[{"c":"FxφGxxψxAxxxxx+ΩYP[SA]+IExI(x){2,3}EGxφxV[HQ]FxxxxxRxxxxψ[HY]φ","u":"47-48","sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved 47-48 aa N-terminal globular domain repeats separated by a 26-aa linker, anchored by fixed F, G, A, +ΩYP[SA]+IExI, EG, V, F, and R positions alongside conserved hydrophobic/aromatic cores and a minor 2-3 aa internal loop variation.","i":[[13,60,"FEIGARLEALDYLQKWYPSRIEKIDYEEGKMLVHFERWSHRYDEWIYW"],[87,133,"FKAGEEVLARWTDCRYYPAKIEAINKEGTFTVQFYDGVIRCLKRMHI"]]}],"s":"MSKKPPNRPGITFEIGARLEALDYLQKWYPSRIEKIDYEEGKMLVHFERWSHRYDEWIYWDSNRLRPLERPALRKEGLKDEEDFFDFKAGEEVLARWTDCRYYPAKIEAINKEGTFTVQFYDGVIRCLKRMHIKAMPEDAKGQVKSQHPLSWCCPIDPAGSCNQSMGSEDWIALVKAAAAAAAKNKTGSKPRTSANSNKDKDKDERKWFKVPSKKEETSTCIATPDVEKKEDLPTSSETFGLHVENVPKMVFPQPESTLSNKRKNNQGNSFQAKRARLNKITGLLASKAVGVDGAEKKEDYNETAPMLEQAISPKPQSQKKNEADISSSANTQKPALLSSTLSSGKARSKKCKHESGDSSGCIKPPKSPLSPELIQVEDLTLVSQLSSSVINKTSPPQPVNPPRPFKHSERRRRSQRLATLPMPDDSVEKVSSPSPATDGKVFSISSQNQQESSVPEVPDVAHLPLEKLGPCLPLDLSRGSEVTAPVASDSSYRNECPRAEKEDTQMLPNPSSKAIADGRGAPAAAGISKTEKKVKLEDKSSTAFGKRKEKDKERREKRDKDHYRPKQKKKKKKKKKSKQHDYSDYEDSSLEFLERCSSPLTRSSGSSLASRSMFTEKTTTYQYPRAILSVDLSGENLSDVDFLDDSSTESLLLSGDEYNQDFDSTNFEESQDEDDALNEIVRCICEMDEENGFMIQCEECLCWQHSVCMGLLEESIPEQYICYICRDPPGQRWSAKYRYDKEWLNNGRMCGLSFFKENYSHLNAKKIVSTHHLLADVYGVTEVLHGLQLKIGILKNKHHPDLHLWACSGKRKDQDQIIAGVEKKIAQDTVNREEKKYVQNHKEPPRLPLKMEGTYITSEHSYQKPQSFGQDCKSLADPGSSDDDDVSSLEEEQEFHMRSKNSLQYSAKEHGMPEKNPAEGNTVFVYNDKKGTEDPGDSHLQWQLNLLTHIENVQNEVTSRMDLIEKEVDVLESWLDFTGELEPPDPLARLPQLKRHIKQLLIDMGKVQQIATLCSV"},{"id":"SEQ_09563","a":"Q969V6","g":"MRTFA","d":"Myocardin-related transcription factor A","L":931,"m":[{"c":"Sxφ[GS]xDφφDGH[DL][DL]oψ[DH]W","u":17,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Two conserved 17-aa C-terminal acidic-hydrophobic/aromatic motif copies separated by a 20-aa Pro/Ser-rich linker, sharing identical S, D, DGH, and W anchors (the only two tryptophans in the entire 931-aa sequence) plus conserved hydrophobic and polar/aliphatic positions.","i":[[874,890,"STMGLDLADGHLDSMDW"],[911,927,"SLFSTDFLDGHDLQLHW"]]}],"s":"MPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERSELVRMHILEETSAEPSLQAKQLKLKRARLADDLNEKIAQRPGPMELVEKNILPVESSLKEAIIVGQVNYPKVADSSSFDEDSSDALSPEQPASHESQGSVPSPLEARVSEPLLSATSASPTQVVSQLPMGRDSREMLFLAEQPPLPPPPLLPPSLTNGTTIPTAKSTPTLIKQSQPKSASEKSQRSKKAKELKPKVKKLKYHQYIPPDQKQDRGAPPMDSSYAKILQQQQLFLQLQILNQQQQQHHNYQAILPAPPKSAGEALGSSGTPPVRSLSTTNSSSSSGAPGPCGLARQNSTSLTGKPGALPANLDDMKVAELKQELKLRSLPVSGTKTELIERLRAYQDQISPVPGAPKAPAATSILHKAGEVVVAFPAARLSTGPALVAAGLAPAEVVVATVASSGVVKFGSTGSTPPVSPTPSERSLLSTGDENSTPGDTFGEMVTSPLTQLTLQASPLQILVKEEGPRAGSCCLSPGGRAELEGRDKDQMLQEKDKQIEALTRMLRQKQQLVERLKLQLEQEKRAQQPAPAPAPLGTPVKQENSFSSCQLSQQPLGPAHPFNPSLAAPATNHIDPCAVAPGPPSVVVKQEALQPEPEPVPAPQLLLGPQGPSLIKGVAPPTLITDSTGTHLVLTVTNKNADSPGLSSGSPQQPSSQPGSPAPAPSAQMDLEHPLQPLFGTPTSLLKKEPPGYEEAMSQQPKQQENGSSSQQMDDLFDILIQSGEISADFKEPPSLPGKEKPSPKTVCGSPLAAQPSPSAELPQAAPPPPGSPSLPGRLEDFLESSTGLPLLTSGHDGPEPLSLIDDLHSQMLSSTAILDHPPSPMDTSELHFVPEPSSTMGLDLADGHLDSMDWLELSSGGPVLSLAPLSTTAPSLFSTDFLDGHDLQLHWDSCL"},{"id":"SEQ_09575","a":"D6RIA3","g":"C4orf54","d":"Uncharacterized protein C4orf54","L":1793,"m":[{"c":"P[HL][FH]QVRDψRxxxK[AG]oG","u":16,"sp":"tandem","x":"disordered_like","cf":"high","why":"Head-to-tail 16-aa tandem duplication embedded in a polar/glycine-rich disordered region, anchored by eight identical positions (P, Q, V, R, D, R, K, G) plus conserved aliphatic (I/V), small (A/G), and polar (Q/S) positions.","i":[[1085,1100,"PHFQVRDIRDKSKAQG"],[1101,1116,"PLHQVRDVRKLIKGSG"]]},{"c":"+xLφDxxTGQY(x){3,8}PMT","u":"17-22","sp":"tandem","x":"structured_like","cf":"high","why":"Head-to-tail tandem duplication sharing a conserved N-terminal +xLφDxxTGQY core and C-terminal PMT tripeptide separated by a 3-8 aa loop that also retains a conserved VD dipeptide (YLVDTPVQ vs VDV).","i":[[1611,1632,"KMLLDVTTGQYYLVDTPVQPMT"],[1633,1649,"RRLFDPETGQYVDVPMT"]]}],"s":"MLSFHFWKSRGQPTDAASSVADGIQTPRCCRRCQANNWTGQLSYRTLATVSAGAAAPQPQTTSTASSRSLPTSLRLAAAPPQGLKNWEVVAAVAAVPTALGPVQIRGTLLRATLQPLRGQRRTQDFPSDHHCLFLSLKPGQGLIMEAAPPELNSKARQAEVGDGVSSAQDSQELKQQLWPLPKPSASSQREAKYVDMCASAEVQRESPQTMKLTLGHCPGGQRASRSPKEKAQDEPSSKTPSPQNNPASSQLSRSQHSASEEGGNFSSSSSSSPMNKAEEDGLSKMEDSTTSTGALATSSSSLGFESESGESEGCQAVGGEGEKISGGGGGGKGGGGGGAGDGTECRDIIAKSQGSRDPPKVEEAHYITTHEIQLSEVEQDMDFDVGLASRWDFEDNNVIYSFVDYASFGGSDETPGDITSLTEEDDDNSCYLSTTPSTNTTRTPSPTSSDLARPNAGRSGRDTSSTEVGSGPSDSGPTPPPTGPGTAPLTEPLPETPEAASGAAAAAASSCGSAASQILLSIKPASRAINEPSNVRAKQNIIYAAKHEGDMSLRVSTAAEHNSSSLKQNPAAAVAQDHAKKFIAVPARLQTRCGAIRAKELVDYSSGASSAVSELDDADKEVRNLTSRAFRSLAYPYFEALNISSRESSTTLSEVGFGRWSTFLDLKCGGVGARVEQSLLRSSAASVAAGLRKGSGARATADQLYIQSKKSQTKALEFVVSKVEGEIKHVETPLCFQKQVQTGSRVVTLLEPLNVRSESKASSAPGPGRATKGPGKGPGSAYTDDGSETSEGSKPTSRADGPQKSKFASSLLKNVISKKMQREHEFKMERGEVMDTSHHLSGTSKETEGARGSERQRERGLQRQSSRHSEAGSEYTVVSMSDAGGEGSVAGSKSPVFKASTPRERNAGPGRNFTDGHTEVCEIKKSASETVKGIFLRSQNSAFRSWKEKEAEKREEQAPIGKLKLPKGGDWRADLGEISASKNTIMSRLFVPNIQQTPKDKQPRKQATKYPAAQATSTAVIRPKAPEIKIRLGSVQQPSSDFNIAKLLTPKLAGGSASNLFKTIEDNSRAQQKLFRGDNLEKVPHFQVRDIRDKSKAQGPLHQVRDVRKLIKGSGDSSDKGSVTPEQGLTGPKPRQLSAAAGGSGSLSPMVITCQAVVNQREDSMDREPRESMGKGGGSRVLNSSSPEGTVLVHRASGRLPVATIAPNKPEQGSYLPVLKIVSKASTQKTPEKLKEEEVKEEGKATKPARNALEKLTAAVRSMEELYSFNRNEWKRKSDPLPMMMDSHVLSLIASEEREGVVVADGDHDKLSKRLGEVEERGTGNKAGVVLRGAPIERLQRRNSNPSAESVSARAAAFENLARERPRSLYIPPVHKDVERTQPLQPLPPLPSNRNVFTVSASSIQKTGGVAGKFPQGPSPESPSAAKGIKSQGLRSLKISPATRAPPDEVTNRKSGSNLEKSNSDCENYLTIPLKGSSAAGELLSRPGASREGPPNSSAATLCSLPPLSARSQVPSSSKGSQVSGTSRPAWRTKPDNPRETVAAPPGPQSPEHPPTTIYHQPPLPFTLQGAQPQVLCFSPPSMPAPAPAASAPVPTDPFQQAQPQQTQRKMLLDVTTGQYYLVDTPVQPMTRRLFDPETGQYVDVPMTSQQQAVAPMSISVPPLALSPGAYGPTYMIYPGFLPTVLPTNALQPTPIARAPRGSELSPMVAEPSSKEAAATFTEAPYFMASGQSPASSTSSAPAATSQLLGAKAFAQLHGKPVISITSQPLGPRIIAPPSFDGTTMSFVVEHR"},{"id":"SEQ_09583","a":"Q8NCP5","g":"ZBTB44","d":"Zinc finger and BTB domain-containing protein 44","L":570,"m":[{"c":"+x[FY]xCxxC[GS]xxFTxxxx[LY][KI]xH(x){3,5}H","u":"25-27","sp":"periodic","x":"structured_like","cf":"high","why":"Four-copy array separated by regular 3-5 aa linkers, defined by invariant CxxC and H(x){3,5}H cysteine/histidine pairs alongside conserved N-terminal basic (+), aromatic ([FY]), [GS], FT, and hydrophobic ([LY]) anchors.","i":[[397,421,"RPFQCPTCGVRFTRIQNLKQHMLIH"],[425,449,"KPFQCDRCGKKFTRAYSLKMHRLKH"],[453,479,"RCFRCQICSATFTSFGEYKHHMRVSRH"],[485,511,"RIYECKTCGAMFTNSGNLIVHLRSLNH"]]}],"s":"MGVKTFTHSSSSHSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDENKNVLDLHHVTVTGFIPLLEYAYTATLSINTENIIDVLAAASYMQMFSVASTCSEFMKSSILWNTPNSQPEKGLDAGQENNSNCNFTSRDGSISPVSSECSVVERTIPVCRESRRKRKSYIVMSPESPVKCGTQTSSPQVLNSSASYSENRNQPVDSSLAFPWTFPFGIDRRIQPEKVKQAENTRTLELPGPSETGRRMADYVTCESTKTTLPLGTEEDVRVKVERLSDEEVHEEVSQPVSASQSSLSDQQTVPGSEQVQEDLLISPQSSSIGSVDEGVSEGLPTLQSTSSTNAPPDDDDRLENVQYPYQLYIAPSTSSTERPSPNGPDRPFQCPTCGVRFTRIQNLKQHMLIHSGIKPFQCDRCGKKFTRAYSLKMHRLKHEGKRCFRCQICSATFTSFGEYKHHMRVSRHIIRKPRIYECKTCGAMFTNSGNLIVHLRSLNHEASELANYFQSSDFLVPDYLNQEQEETLVQYDLGEHGFESNSSVQMPVISQYHSKGKEP"},{"id":"SEQ_09593","a":"Q8TEW8","g":"PARD3B","d":"Partitioning defective 3 homolog B","L":1205,"m":[{"c":"[GP]LGφxψ(x){11,12}[GP]ψFψ+xIxxx[GS][AR][AS]x+-G[RL]φxx[NG]-xψψxψN[GN]x[DS]ψx[GD]+[TS]xx[EQ]φxxxφRx[AST][MK]x(x){5,10}L[HV]ψφ","u":"76-82","sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed 76-82 aa globular domain repeats anchored by an N-terminal [GP]LGφxψ motif, a conserved 50-residue core containing fixed F, I, G, N, and R anchors plus conserved hydrophobic and charged positions, and a C-terminal L[HV]ψφ motif.","i":[[212,288,"PLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVL"],[392,467,"GLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIA"],[508,589,"GLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVIL"]]}],"s":"MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILDPDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGGEIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPTPHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKVHSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNESFRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGLREEELEKMKEERERIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMDPNYARVNHFREPCTSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPLVPADSGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNLRFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELRVADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQDSRQKNPMTAAV"},{"id":"SEQ_09608","a":"P27658","g":"COL8A1","d":"Collagen alpha-1(VIII) chain","L":744,"m":[{"c":"GKEφP[HL][LA]","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three 7-aa motifs in the N-terminal disordered region preceding the collagenous G-x-y tract share invariant GKE and P anchors plus hydrophobic position 4 (M/Y/I) and constrained [HL][LA] C-terminal residues, with two degenerate KE-containing spacer variants (MKEIQP, GKEAVP) between copies 2 and 3.","i":[[71,77,"GKEMPHL"],[80,86,"GKEYPHL"],[108,114,"GKEIPLA"]]}],"s":"MAVLPGPLQLLGVLLTISLSSIRLIQAGAYYGIKPLPPQIPPQMPPQIPQYQPLGQQVPHMPLAKDGLAMGKEMPHLQYGKEYPHLPQYMKEIQPAPRMGKEAVPKKGKEIPLASLRGEQGPRGEPGPRGPPGPPGLPGHGIPGIKGKPGPQGYPGVGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFGMPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPPGIPGIGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPGALGPQGQPGLPGPPGPPGPPGPPAVMPPTPPPQGEYLPDMGLGIDGVKPPHAYGAKKGKNGGPAYEMPAFTAELTAPFPPVGAPVKFNKLLYNGRQNYNPQTGIFTCEVPGVYYFAYHVHCKGGNVWVALFKNNEPVMYTYDEYKKGFLDQASGSAVLLLRPGDRVFLQMPSEQAAGLYAGQYVHSSFSGYLLYPM"},{"id":"SEQ_09632","a":"O94983","g":"CAMTA2","d":"Calmodulin-binding transcription activator 2","L":1202,"m":[{"c":"AAx[VL]IQxx[FY]R[KS]Y[KRY]","u":13,"sp":"dispersed","x":"structured_like","cf":"high","why":"Four strongly conserved C-terminal amphipathic helical IQ-type motifs anchored by invariant AA, IQ, R, and Y positions plus conserved aliphatic ([VL]), aromatic ([FY]), and basic/polar ([KS], [KRY]) residues, separated by 10-17 aa helical linkers.","i":[[1051,1063,"AARVIQTAFRKYK"],[1074,1086,"AAAVIQRCYRKYK"],[1104,1116,"AAILIQSKFRSYY"],[1127,1139,"AAVLIQQHYRSYR"]]},{"c":"[LP]LxφAx[AS]xG[HY]φ[ER][AL][AI]xxLxx[LW](x){0,1}R","u":"21-22","sp":"dispersed","x":"structured_like","cf":"high","why":"Three ankyrin-like helical repeats anchored by N-terminal [LP]L, central A and G[HY]φ motifs, conserved hydrophobic core positions, and a C-terminal R, with a 1-residue length difference before the terminal R in the first copy.","i":[[714,734,"LLHLAAAQGYARLIETLSQWR"],[759,780,"PLMWACALGHLEAAVLLFRWNR"],[793,814,"PLSVAHSRGHVRLARCLEELQR"]]}],"s":"MNTKDTTEVAENSHHLKIFLPKKLLECLPRCPLLPPERLRWNTNEEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKYRKDGYLWKKRKDGKTTREDHMKLKVQGMECLYGCYVHSSIVPTFHRRCYWLLQNPDIVLVHYLNVPALEDCGKGCSPIFCSISSDRREWLKWSREELLGQLKPMFHGIKWSCGNGTEEFSVEHLVQQILDTHPTKPAPRTHACLCSGGLGSGSLTHKCSSTKHRIISPKVEPRALTLTSIPHAHPPEPPPLIAPLPPELPKAHTSPSSSSSSSSSGFAEPLEIRPSPPTSRGGSSRGGTAILLLTGLEQRAGGLTPTRHLAPQADPRPSMSLAVVVGTEPSAPPAPPSPAFDPDRFLNSPQRGQTYGGGQGVSPDFPEAEAAHTPCSALEPAAALEPQAAARGPPPQSVAGGRRGNCFFIQDDDSGEELKGHGAAPPIPSPPPSPPPSPAPLEPSSRVGRGEALFGGPVGASELEPFSLSSFPDLMGELISDEAPSIPAPTPQLSPALSTITDFSPEWSYPEGGVKVLITGPWTEAAEHYSCVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPLSASVLFEYRARRFLSLPSTQLDWLSLDDNQFRMSILERLEQMEKRMAEIAAAGQVPCQGPDAPPVQDEGQGPGFEARVVVLVESMIPRSTWKGPERLAHGSPFRGMSLLHLAAAQGYARLIETLSQWRSVETGSLDLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFRWNRQALSIPDSLGRLPLSVAHSRGHVRLARCLEELQRQEPSVEPPFALSPPSSSPDTGLSSVSSPSELSDGTFSVTSAYSSAPDGSPPPAPLPASEMTMEDMAPGQLSSGVPEAPLLLMDYEATNSKGPLSSLPALPPASDDGAAPEDADSPQAVDVIPVDMISLAKQIIEATPERIKREDFVGLPEAGASMRERTGAVGLSETMSWLASYLENVDHFPSSTPPSELPFERGRLAVPSAPSWAEFLSASTSGKMESDFALLTLSDHEQRELYEAARVIQTAFRKYKGRRLKEQQEVAAAVIQRCYRKYKQLTWIALKFALYKKMTQAAILIQSKFRSYYEQKRFQQSRRAAVLIQQHYRSYRRRPGPPHRTSATLPARNKGSFLTKKQDQAARKIMRFLRRCRHRMRELKQNQELEGLPQPGLAT"},{"id":"SEQ_09635","a":"Q9UPN6","g":"SCAF8","d":"SR-related and CTD-associated factor 8","L":1271,"m":[{"c":"[NS][IV]x[NS]o[PS][EG][IL]ψ[AG]x[QLR][PR][PS]","u":14,"sp":"tandem","x":"disordered_like","cf":"high","why":"Contiguous head-to-tail array of seven 14-aa repeats within a proline/polar-rich region (preceded by a divergent 15-aa copy NDISSNAAILGGQPP), featuring conserved N-terminal [NS][IV], central polar-glycine-aliphatic ([NS]o[PS][EG][IL]ψ[AG]), and C-terminal [QLR][PR][PS] anchors.","i":[[805,818,"NVTSNSGILGVQRP"],[819,832,"NVSSNSEILGVRPS"],[833,846,"NVSSSSGIIAAQPP"],[847,860,"NILNNSGILGIQPP"],[861,874,"SVSNSSGLLGVLPP"],[875,888,"NIPNNSGLVGVQPP"],[889,902,"NVPNTPGLLGTQPP"]]}],"s":"MEAVKTFNSELYSLNDYKPPISKAKMTQITKAAIKAIKFYKHVVQSVEKFIQKCKPEYKVPGLYVIDSIVRQSRHQFGQEKDVFAPRFSNNIISTFQNLYRCPGDDKSKIVRVLNLWQKNNVFKSEIIQPLLDMAAGIPPPVVTPVLASTTTAMSNTPGTPVTPVTPANVVQGLPDPWVSQITNTDTLAAVAQILQSPQGQQLQQLIQTLQIQQQKPQPSILQALDAGLVVQLQALTAQLTAAAAAANTLTPLEQGVSFNKKLMDRFDFGEDSEHSEEPKKEIPASQLSHVSESVNNSIFHQIAEQLQQQNLEHLRQQLLEQQQPQKATPQDSQEGTFGSEHSASPSQGSSQQHFLEPEVNLDDSIDIQQQDMDIDEGQDGVEEEVFEQEAKKVAVRSRSRTHSRSRSRSPRKRRSRSRSGSRKRKHRKRSRSRSRERKRKSSRSYSSERRAREREKERQKKGLPPIRSKTLSVCSTTLWVGQVDKKATQQDLTNLFEEFGQIESINMIPPRGCAYVCMVHRQDAFRALQKLSSGSYKIGSKVIKIAWALNKGVKTEYKQFWDVDLGVTYIPWEKVKVDDLEGFAEGGMIDQETVNTEWETVKSSEPVKETVQTTQSPTPVEKETVVTTQAEVFPPPVAMLQIPVAPAVPTVSLVPPAFPVSMPVPPPGFSPIPPPPFLRASFNPSQPPPGFMPPPVPPPVVPPPTIPPVVPTSLVQPSLSMTPETVKDVGFGSLVIPGGSVASNLATSALPAGNVFNAPTKQAEPEEKVPHLIDHQISSGENTRSVIPNDISSNAAILGGQPPNVTSNSGILGVQRPNVSSNSEILGVRPSNVSSSSGIIAAQPPNILNNSGILGIQPPSVSNSSGLLGVLPPNIPNNSGLVGVQPPNVPNTPGLLGTQPPAGPQNLPPLSIPNQRMPTMPMLDIRPGLIPQAPGPRFPLIQPGIPPQRGIPPPSVLDSALHPPPRGPFPPGDIFSQPERPFLAPGRQSVDNVTNPEKRIPLGNDNIQQEGDRDYRFPPIETRESISRPPPVDVRDVVGRPIDPREGPGRPPLDGRDHFGRPPVDIRENLVRPGIDHLGRRDHFGFNPEKPWGHRGDFDEREHRVLPVYGGPKGLHEERGRFRSGNYRFDPRSGPWNRGFGQEVHRDFDDRRRPWERQRDRDDRDFDFCREMNGNRLGRDRIQNTWVPPPHARVFDYFEGATSQRKGDNVPQVNGENTERHAQPPPIPVQNDPELYEKLTSSNEINKEKSDTVADIESEPVVESTETEGT"},{"id":"SEQ_09647","a":"Q9Y4E1","g":"WASHC2C","d":"WASH complex subunit 2C","L":1341,"m":[{"c":"-xx[DN][LI]F","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Eleven dispersed 6-aa disordered-region motifs anchored by an N-terminal acidic residue (-), a conserved [DN] position, a large aliphatic [LI], and an invariant C-terminal F.","i":[[257,262,"DGCDLF"],[336,341,"EEDNLF"],[373,378,"EESDLF"],[486,491,"EEGDLF"],[543,548,"DSEDLF"],[578,583,"EEDNLF"],[883,888,"EDDDLF"],[1131,1136,"DSGDIF"],[1204,1209,"DEDDLF"],[1265,1270,"DNIDIF"],[1294,1299,"DMDDIF"]]},{"c":"[GSL]LFx--","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Nine dispersed 6-aa disordered-region motifs with a constrained [GSL]LF N-terminal core followed by a C-terminal acidic dipeptide (--), frequently positioned immediately upstream of -xx[DN][LI]F motifs across variable acidic linkers.","i":[[366,371,"GLFDDE"],[449,454,"GLFDDD"],[536,541,"GLFSDE"],[571,576,"SLFDDE"],[663,668,"SLFEED"],[689,694,"LLFEDD"],[725,730,"LLFSDE"],[802,807,"SLFDEE"],[877,882,"SLFGDD"]]}],"s":"MMNRTTPDQELVPASEPVWERPWSVEEIRRSSQSWSLAADAGLLQFLQEFSQQTISRTHEIKKQVDGLIRETKATDCRLHNVFNDFLMLSNTQFIENRVYDEEVEEPVLKAEAEKTEQEKTREQKEVDLIPKVQEAVNYGLQVLDSAFEQLDIKAGNSDSEEDDANGRVELILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIVDTEEEKEEEESDEDFAHHSDNEQNQHTTQMSDEEEDDDGCDLFADSEKEEEDIEDIEENTRPKRSRPTSFADELAARIKGDAMGRVDEEPTTLPSGEAKPRKTLKEKKERRTPSDDEEDNLFAPPKLTDEDFSPFGSGGGLFSGGKGLFDDEDEESDLFTEASQDRQAGASVKEESSSSKPGKKIPAGAVSVFLGDTDVFGAASVPSLKEPQKPEQPTPRKSPYGPPPTGLFDDDDGDDDDDFFSAPHSKPSKTRKVQSTADIFGDEEGDLFKEKAVASPEATVSQTDENKARAEKKVTLSYSKNLKPSSETKTQKGLFSDEEDSEDLFSSQSASNLKGASLLPGKLPTSVSLFDDEDEEDNLFGGTAAKKQTLSLQAQREEKAKASELSKKKASALLFSSDEEDQWNIPASQTHLASDSRSKGEPRDSGTLQSQEAKAVKKTSLFEEDKEDDLFAIAKDSQKKTQRVSLLFEDDVDSGGSLFGSPPTSVPPATKKKETVSEAPPLLFSDEEEKEAQLGVKSVDKKVESAKESLKFGRTDVAESEKEGLLTRSAQETVKHSDLFSSSSPWDKGTKPRTKTVLSLFDEEEDKMEDQNIIQAPQKEVGKGCDPDAHPKSTGVFQDEELLFSHKLQKDNDPDVDLFAGTKKTKLLEPSVGSLFGDDEDDDLFSSAKSQPLVQEKKRVVKKDHSVNSFKNQKHPESIQGSKEKGIWKPETPQDSSGLAPFKTKEPSTRIGKIQANLAINPAALLPTAASQISEVKPVLPELAFPSSEHRRSHGLESVPVLPGSGEAGVSFDLPAQADTLHSANKSRVKMRGKRRPQTRAARRLAAQESSEAEDMSVPRGPIAQWADGAISPNGHRPQLRAASGEDSTEEALAAAAAPWEGGPVPGVDTSPFAKSLGHSRGEADLFDSGDIFSTGTGSQSVERTKPKAKIAENPANPPVGGKAKSPMFPALGEASSDDDLFQSAKPKPAKKTNPFPLLEDEDDLFTDQKVKKNETKSSSQQDVILTTQDIFEDDIFATEAIKPSQKTREKEKTLESNLFDDNIDIFADLTVKPKEKSKKKVEAKSIFDDDMDDIFSTGIQAKTTKPKSRSAQAAPEPRFEHKVSNIFDDPLNAFGGQ"},{"id":"SEQ_09654","a":"Q86TG7","g":"PEG10","d":"Retrotransposon-derived protein PEG10","L":708,"m":[{"c":"[LV]YxPV","u":5,"sp":"dispersed","x":"mixed","cf":"medium","why":"Four occurrences of a 5-residue motif anchored by strictly invariant Tyr2, Pro4, and Val5 plus a conserved Leu/Val position at pos 1, with three copies clustered in a Tyr/Pro-rich region (493-518) and a fourth C-terminal copy (666-670).","i":[[493,497,"LYYPV"],[502,506,"VYQPV"],[514,518,"VYTPV"],[666,670,"LYVPV"]]}],"s":"MTERRRDELSEEINNLREKVMKQSEENNNLQSQVQKLTEENTTLREQVEPTPEDEDDDIELRGAAAAAAPPPPIEEECPEDLPEKFDGNPDMLAPFMAQCQIFMEKSTRDFSVDRVRVCFVTSMMTGRAARWASAKLERSHYLMHNYPAFMMEMKHVFEDPQRREVAKRKIRRLRQGMGSVIDYSNAFQMIAQDLDWNEPALIDQYHEGLSDHIQEELSHLEVAKSLSALIGQCIHIERRLARAAAARKPRSPPRALVLPHIASHHQVDPTEPVGGARMRLTQEEKERRRKLNLCLYCGTGGHYADNCPAKASKSSPAGKLPGPAVEGPSATGPEIIRSPQDDASSPHLQVMLQIHLPGRHTLFVRAMIDSGASGNFIDHEYVAQNGIPLRIKDWPILVEAIDGRPIASGPVVHETHDLIVDLGDHREVLSFDVTQSPFFPVVLGVRWLSTHDPNITWSTRSIVFDSEYCRYHCRMYSPIPPSLPPPAPQPPLYYPVDGYRVYQPVRYYYVQNVYTPVDEHVYPDHRLVDPHIEMIPGAHSIPSGHVYSLSEPEMAALRDFVARNVKDGLITPTIAPNGAQVLQVKRGWKLQVSYDCRAPNNFTIQNQYPRLSIPNLEDQAHLATYTEFVPQIPGYQTYPTYAAYPTYPVGFAWYPVGRDGQGRSLYVPVMITWNPHWYRQPPVPQYPPPQPPPPPPPPPPPPSYSTL"},{"id":"SEQ_09666","a":"Q8TDD2","g":"SP7","d":"Transcription factor Sp7","L":431,"m":[{"c":"[FH][SVT]C(x){2,4}C[GS]K[VR][FY][GT]+[AS][SD][HE]LxxHxR[WT]H","u":"23-25","sp":"periodic","x":"structured_like","cf":"high","why":"Three periodic 23-25 aa repeats separated by regular 5-aa linkers (TGERP, TREKK), defined by an invariant C(x){2,4}C and HxR[WT]H cysteine-histidine core with fixed K and L anchors and conserved aromatic ([FH], [FY]) and basic (+) positions.","i":[[294,318,"HSCHIPGCGKVYGKASHLKAHLRWH"],[324,348,"FVCNWLFCGKRFTRSDELERHVRTH"],[354,376,"FTCLLCSKRFTRSDHLSKHQRTH"]]}],"s":"MASSLLEEEVHYGSSPLAMLTAACSKFGGSSPLRDSTTLGKAGTKKPYSVGSDLSASKTMGDAYPAPFTSTNGLLSPAGSPPAPTSGYANDYPPFSHSFPGPTGTQDPGLLVPKGHSSSDCLPSVYTSLDMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQGTLPTGPAQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQHVLPQDVYKPKAVGNSGQLEGSGGAKPPRGASTGGSGGYGGSGAGRSSCDCPNCQELERLGAAAAGLRKKPIHSCHIPGCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLCSKRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSTGEEEASQTPRPSASPATPEKAPGGSPEQSNLLEI"},{"id":"SEQ_09672","a":"Q32P44","g":"EML3","d":"Echinoderm microtubule-associated protein-like 3","L":896,"m":[{"c":"xxxxxxxxφxxxx[DRS]xxxxxxx(x){3,14}xφxx[WLY]x","u":"30-41","sp":"dispersed","x":"structured_like","cf":"high","why":"Ten structured ~31-aa beta-propeller blades (one with an extended internal loop) anchored by N-terminal GH/AH dipeptides in 6 copies, conserved hydrophobic strand positions, a P[DRS] turn motif, and a C-terminal W[DGNGR] motif in 8 of 10 copies. Separated by variable inter-blade linkers (10-83 aa, spanning two additional divergent blades); the P/G/S-biased N-terminal disordered region lacks multi-position anchored repeats.","i":[[303,343,"GHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWD"],[358,391,"FERGVGALAFSAADQGAFLCVVDDSNEHMLSVWD"],[403,433,"STNDSVLAVGFNPRDSSCIVTSGKSHVHFWN"],[457,486,"KKPKFIPCFVFLPDGDILTGDSEGNILTWG"],[512,542,"AHEGSIFALCLRRDGTVLSGGGRDRRLVQWG"],[595,625,"GHTDELWGLCTHPSQNRFLTCGHDRQLCLWD"],[636,666,"DLKETGLCADFHPSGAVVAVGLNTGRWLVLD"],[678,708,"DGNEQLSVVRYSPDGLYLAIGSHDNVIYIYS"],[724,754,"GHSSFITHLDWSKDGNFIMSNSGDYEILYWD"],[837,868,"GHGSHVTSVRFTHDDSHLVSLGGKDASIFQWR"]]}],"s":"MDGAAGPGDGPAREALQSLSQRLRVQEQEMELVKAALAEALRLLRLQVPPSSLQGSGTPAPPGDSLAAPPGLPPTCTPSLVSRGTQTETEVELKSSPGPPGLSNGPPAPQGASEEPSGTQSEGGGSSSSGAGSPGPPGILRPLQPPQRADTPRRNSSSSSSPSERPRQKLSRKAISSANLLVRSGSTESRGGKDPLSSPGGPGSRRSNYNLEGISVKMFLRGRPITMYIPSGIRSLEELPSGPPPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRHYRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERGVGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCIVTSGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPDGDILTGDSEGNILTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPGLVALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQGFSPVIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESRDREWATYTCVLGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAKAPSRMYGGHGSHVTSVRFTHDDSHLVSLGGKDASIFQWRVLGAGGAGPAPATPSRTPSLSPASSLDV"},{"id":"SEQ_09679","a":"P20749","g":"BCL3","d":"B-cell lymphoma 3 protein","L":454,"m":[{"c":"xx[GR]x[TS][PA][LA][HI]xA[VCS]xxxxxxxψxxL[LV](x){2,6}[GT][ARL]xxxxx[NDM]","u":"33-37","sp":"tandem","x":"structured_like","cf":"high","why":"Six tandem 33-37 aa structured repeats (followed by a truncated 25-aa C-terminal cap starting at CHNDTPLMVAR...) defined by invariant A and L core positions, a conserved [TS][PA][LA][HI]xA helix-turn motif, aliphatic V/L packing residues, and a C-terminal GAx5[NDM] loop. Flanking Pro/Ser-rich N- and C-terminal disordered tails show compositional bias without multi-position anchored repeats.","i":[[133,169,"EDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYN"],[170,202,"NLRQTPLHLAVITTLPSVVRLLVTAGASPMALD"],[203,239,"RHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARN"],[240,272,"YDGLTALHVAVNTECQETVQLLLERGADIDAVD"],[274,306,"KSGRSPLIHAVENNSLSMVQLLLQHGANVNAQM"],[307,339,"YSGSSALHSASGRGLLPLVRTLVRSGADSSLKN"]]}],"s":"MPRCPAGAMDEGPVDLRTRPKAAGLPGAALPLRKRPLRAPSPEPAAPRGAAGLVVPLDPLRGGCDLPAVPGPPHGLARPEALYYPGALLPLYPTRAMGSPFPLVNLPTPLYPMMCPMEHPLSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQPDPSPDRSANTSPESSSRLSSNGLLSASPSSSPSQSPPRDPPGFPMAPPNFFLPSPSPPAFLPFAGVLRGPGRPVPPSPAPGGS"},{"id":"SEQ_09690","a":"Q68DA7","g":"FMN1","d":"Formin-1","L":1419,"m":[{"c":"PPPP[PG]L","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five non-overlapping copies clustered within an ~85-residue disordered proline-rich region (aa 876-959), each consisting of a four-proline core followed by P or G and capped by an invariant C-terminal leucine anchor.","i":[[876,881,"PPPPPL"],[908,913,"PPPPPL"],[925,930,"PPPPPL"],[946,951,"PPPPGL"],[954,959,"PPPPGL"]]}],"s":"MEGTHCTLQLHKPITELCYISFCLPKGEVRGFSYKGTVTLDRSNKGFHNCYQVREESDIISLSQEPDEHPGDIFFKQTPTKDILTELYKLTTERERLLTNLLSSDHILGITMGNQEGKLQELSVSLAPEDDCFQSAGDWQGELPVGPLNKRSTHGNKKPRRSSGRRESFGALPQKRTKRKGRGGRESAPLMGKDKICSSHSLPLSRTRPNLWVLEEKGNLLPNGALACSLQRRESCPPDIPKTPDTDLGFGSFETAFKDTGLGREVLPPDCSSTEAGGDGIRRPPSGLEHQQTGLSESHQDPEKHPEAEKDEMEKPAKRTCKQKPVSKVVAKVQDLSSQVQRVVKTHSKGKETIAIRPAAHAEFVPKADLLTLPGAEAGAHGSRRQGKERQGDRSSQSPAGETASISSVSASAEGAVNKVPLKVIESEKLDEAPEGKRLGFPVHTSVPHTRPETRNKRRAGLPLGGHKSLFLDLPHKVGPDSSQPRGDKKKPSPPAPAALGKVFNNSASQSSTHKQTSPVPSPLSPRLPSPQQHHRILRLPALPGEREAALNDSPCRKSRVFSGCVSADTLEPPSSAKVTETKGASPAFLRAGQPRLVPGETLEKSLGPGKTTAEPQHQSPPGISSEGFPWDGFNEQTPKDLPNRDGGAWVLGYRAGPACPFLLHEEREKSNRSELYLDLHPDHSLTEQDDRTPGRLQAVWPPPKTKDTEEKVGLKYTEAEYQAAILHLKREHKEEIENLQAQFELRAFHIRGEHAMITARLEETIENLKHELEHRWRGGCEERKDVCISTDDDCPPKTFRNVCVQTDRETFLKPCESESKTTRSNQLVPKKLNISSLSQLSPPNDHKDIHAALQPMEGMASNQQKALPPPPASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLPPPPPPPPPLPPPSSAGPPPPPPPPPLPNSPAPPNPGGPPPAPPPPGLAPPPPPGLFFGLGSSSSQCPRKPAIEPSCPMKPLYWTRIQISDRSQNATPTLWDSLEEPDIRDPSEFEYLFSKDTTQQKKKPLSETYEKKNKVKKIIKLLDGKRSQTVGILISSLHLEMKDIQQAIFNVDDSVVDLETLAALYENRAQEDELVKIRKYYETSKEEELKLLDKPEQFLHELAQIPNFAERAQCIIFRSVFSEGITSLHRKVEIITRASKDLLHVKSVKDILALILAFGNYMNGGNRTRGQADGYSLEILPKLKDVKSRDNGINLVDYVVKYYLRYYDQEAGTEKSVFPLPEPQDFFLASQVKFEDLIKDLRKLKRQLEASEKQMVVVCKESPKEYLQPFKDKLEEFFQKAKKEHKMEESHLENAQKSFETTVRYFGMKPKSGEKEITPSYVFMVWYEFCSDFKTIWKRESKNISKERLKMAQESVSKLTSEKKVETKKINPTASLKERLRQKEASVTTN"},{"id":"SEQ_09695","a":"P16401","g":"H1-5","d":"Histone 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positions.","i":[[242,256,"KSPLFQFAEISSSTS"],[267,281,"TSALFQFAEISSNTS"],[294,308,"KSALFQLAEMCLASE"]]}],"s":"MKGSNRNKDHSAEGEGVGKRPKRKCLQWHPLLAKKLLDFSEEEEEEDEEEDIDKVQLLGADGLEQDVGETEDDESPEQRARRPMNAFLLFCKRHRSLVRQEHPRLDNRGATKILADWWAVLDPKEKQKYTDMAKEYKDAFMKANPGYKWCPTTNKPVKSPTPTVNPRKKLWAFPSDSSRDLPSPKKAKTEEMPQLNFGMADPTQMGGLSMLLLAGEHALGTPEVSSGTCRPDVSESPELRQKSPLFQFAEISSSTSHSDASTKQCQTSALFQFAEISSNTSQLGGAEPVKRCGKSALFQLAEMCLASEGMKMEESKLIKAKESDGGRIKELEKGKEEKEIKMEKTDETRLQKEAEFEKSAKENLRDSKELRNFEALQIDDIMAIKMEDPKEIRKEELEEDHKCSHFPDFSYSASSKIIISDVPSRKDHMCHPHGIMIIEDPAALNKPEKLKKKKKKSKMDRHGNDKSTPKKTCKKRQSSESDIESVIYTIEAVAKGDWGIEKLGDTPRKKVRTSSSGKGSILDAKPPKKKVKSREKKMSKEKSSDTTKESRPPDFISISASKNISGETPEGIKAEPLTPMEDALPPSLSGQAKPEDSDCHRKIETCGSRKSERSCKGALYKTLVSEGMLTSLRANVDRGKRSSGKGNSSDHEGCWNEESWTFSQSGTSGSKKFKKTKPKEDCLLGSAKLDEEFEKKFNSLPQYSPVTFDRKCVPVPRKKKKTGNVSSEPTKTSKGPFQSQKKNLFHKIVSKYKHKKEKPNVPEKGSGDKWSNKQLFLDAIHPTEAIFSEDRNTMEPVHKVKNIPSIFNTPEPTTTQEPLVGSQKRKARKTKITHLVRTADGRVSPAGGTLDDKPKEQLQRSLPKATETDCNDKCSHNTEVGETRSSTPEMPAVSAFFSLAALAEVAAMENVHRGQRSTPLTHDGQPKEMPQAPVLISCADQ"},{"id":"SEQ_09698","a":"Q8IYB5","g":"SMAP1","d":"Stromal membrane-associated protein 1","L":467,"m":[{"c":"[DG][DL]L[DG]ψ[DF]","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three dispersed 6-residue acidic-hydrophobic motif islands occur within an 80-residue P/T/S/A-rich, hydrophobic-depleted disordered linker; copies 1 and 2 share an extended PxxD[DL]L[DG]ψ[DF]GP frame while copies 2 and 3 share [DG]DLDψF.","i":[[217,222,"DLLGLD"],[241,246,"DDLDIF"],[280,285,"GDLDLF"]]}],"s":"MATRSCREKAQKLNEQHQLILSKLLREEDNKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTAEQIQCMQDMGNTKARLLYEANLPENFRRPQTDQAVEFFIRDKYEKKKYYDKNAIAITNISSSDAPLQPLVSSPSLQAAVDKNKLEKEKEKKKEEKKREKEPEKPAKPLTAEKLQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAVAPVTNGNTTVPPLNDDLDIFGPMISNPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGTIQQQSTPGVFMGPTNIPFTSQAPAAFQGFPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQSKFGLPQAQQPQWSLSQMNQQMAGMSISSATPTAGFGQPSSTTAGWSGSSSGQTLSTQLWK"},{"id":"SEQ_09721","a":"Q9NRR5","g":"UBQLN4","d":"Ubiquilin-4","L":601,"m":[{"c":"NPxφxxxψx","u":9,"sp":"dispersed","x":"mixed","cf":"high","why":"Twelve 9-aa amphipathic repeats anchored by an invariant N-terminal NP cap and strongly conserved hydrophobic/aliphatic positions 4 and 8 (M/L/I/V/F), organized into two clusters with tandem-to-short variable linkers.","i":[[192,200,"NPEMLSQIM"],[202,210,"NPLVQDMMS"],[211,219,"NPDLMRHMI"],[222,230,"NPQMQQLME"],[232,240,"NPEISHMLN"],[241,249,"NPELMRQTM"],[254,262,"NPAMMQEMM"],[393,401,"NPQLMQNVI"],[416,424,"NPDFAAQMM"],[433,441,"NPQLQEQLR"],[453,461,"NPESLSILT"],[462,470,"NPRAMQALL"]]}],"s":"MAEPSGAETRPPIRVTVKTPKDKEEIVICDRASVKEFKEEISRRFKAQQDQLVLIFAGKILKDGDTLNQHGIKDGLTVHLVIKTPQKAQDPAAATASSPSTPDPASAPSTTPASPATPAQPSTSGSASSDAGSGSRRSSGGGPSPGAGEGSPSATASILSGFGGILGLGSLGLGSANFMELQQQMQRQLMSNPEMLSQIMENPLVQDMMSNPDLMRHMIMANPQMQQLMERNPEISHMLNNPELMRQTMELARNPAMMQEMMRNQDRALSNLESIPGGYNALRRMYTDIQEPMFSAAREQFGNNPFSSLAGNSDSSSSQPLRTENREPLPNPWSPSPPTSQAPGSGGEGTGGSGTSQVHPTVSNPFGINAASLGSGMFNSPEMQALLQQISENPQLMQNVISAPYMRSMMQTLAQNPDFAAQMMVNVPLFAGNPQLQEQLRLQLPVFLQQMQNPESLSILTNPRAMQALLQIQQGLQTLQTEAPGLVPSLGSFGISRTPAPSAGSNAGSTPEAPTSSPATPATSSPTGASSAQQQLMQQMIQLLAGSGNSQVQTPEVRFQQQLEQLNSMGFINREANLQALIATGGDINAAIERLLGSQLS"},{"id":"SEQ_09732","a":"Q92859","g":"NEO1","d":"Neogenin","L":1461,"m":[{"c":"P(x){13,16}IxψxW(x){12,15}Y(x){26,31}LxxxxxYxφxψx[AV](x){15,16}Tx","u":"89-97","sp":"dispersed","x":"structured_like","cf":"high","why":"Six 89-97 aa structured repeats in the central region defined by an N-terminal P, invariant IxψxW motif, conserved internal Y, and a C-terminal LxxxxxYxφxψx[AV]...(T) core separated by short 3-27 aa linkers.","i":[[439,533,"PSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQ"],[541,629,"PAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTL"],[633,729,"PSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETF"],[739,828,"PEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTR"],[856,950,"PPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTF"],[957,1052,"PPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTP"]]},{"c":"xxxxxxxxψφxCxxxxxxxPxψxW(x){29,36}DxGxYxCψ(x){15,16}ψx","u":"78-86","sp":"periodic","x":"structured_like","cf":"high","why":"Four 78-86 aa N-terminal structured repeats anchored by invariant CxxxxxxxPxψxW and DxGxYxCψ cores with conserved flanking aliphatic residues, separated by regular 12-18 aa proline-containing linkers.","i":[[63,148,"LSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIV"],[162,240,"SVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL"],[259,338,"VRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQ"],[351,428,"YAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIIL"]]}],"s":"MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDELTKEMAHLEGLMKDLNAITTA"},{"id":"SEQ_09746","a":"Q9BWE0","g":"REPIN1","d":"DNA-binding protein REPIN1","L":567,"m":[{"c":"xxx+PΩxCxxCG+xFxxxxxLxxH(x){3,4}H","u":"28-29","sp":"tandem","x":"structured_like","cf":"high","why":"Fifteen 28-29 aa C2H2-type repeats organized in three predominantly head-to-tail tandem clusters separated by two proline-rich linkers, anchored by invariant C, F, L, and H positions plus conserved P, aromatic, G, and basic residues.","i":[[52,79,"APGRAHRCAHCRRHFPGWVALWLHTRRC"],[80,107,"QARLPLPCPECGRRFRHAPFLALHRQVH"],[111,138,"TPDLGFACHLCGQSFRGWVALVLHLRAH"],[140,168,"AAKRPIACPKCERRFWRRKQLRAHLRRCH"],[172,199,"PEARPFICGNCGRSFAQWDQLVAHKRVH"],[231,258,"AVDRPFQCACCGKRFRHKPNLIAHRRVH"],[259,286,"TGERPHQCPECGKRFTNKPYLTSHRRIH"],[287,314,"TGEKPYPCKECGRRFRHKPNLLSHSKIH"],[370,397,"APPSLYSCDDCGRSFRLERFLRAHQRQH"],[398,425,"TGERPFTCAECGKNFGKKTHLVAHSRVH"],[426,453,"SGERPFACEECGRRFSQGSHLAAHRRDH"],[454,481,"APDRPFVCPDCGKAFRHKPYLAAHRRIH"],[482,509,"TGEKPYVCPDCGKAFSQKSNLVSHRRIH"],[510,537,"TGERPYACPDCDRSFSQKSNLITHRKSH"],[538,565,"IRDGAFCCAICGQTFDDEERLLAHQKKH"]]}],"s":"MLERRCRGPLAMGLAQPRLLSGPSQESPQTLGKESRGLRQQGTSVAQSGAQAPGRAHRCAHCRRHFPGWVALWLHTRRCQARLPLPCPECGRRFRHAPFLALHRQVHAAATPDLGFACHLCGQSFRGWVALVLHLRAHSAAKRPIACPKCERRFWRRKQLRAHLRRCHPPAPEARPFICGNCGRSFAQWDQLVAHKRVHVAEALEEAAAKALGPRPRGRPAVTAPRPGGDAVDRPFQCACCGKRFRHKPNLIAHRRVHTGERPHQCPECGKRFTNKPYLTSHRRIHTGEKPYPCKECGRRFRHKPNLLSHSKIHKRSEGSAQAAPGPGSPQLPAGPQESAAEPTPAVPLKPAQEPPPGAPPEHPQDPIEAPPSLYSCDDCGRSFRLERFLRAHQRQHTGERPFTCAECGKNFGKKTHLVAHSRVHSGERPFACEECGRRFSQGSHLAAHRRDHAPDRPFVCPDCGKAFRHKPYLAAHRRIHTGEKPYVCPDCGKAFSQKSNLVSHRRIHTGERPYACPDCDRSFSQKSNLITHRKSHIRDGAFCCAICGQTFDDEERLLAHQKKHDV"},{"id":"SEQ_09749","a":"Q5T8P6","g":"RBM26","d":"RNA-binding 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positions.","i":[[631,648,"VVKQSVKERLGPVPSSTI"],[664,681,"VTKLSVKDRLGFVSKPSV"]]}],"s":"MVSKMIIENFEALKSWLSKTLEPICDADPSALAKYVLALVKKDKSEKELKALCIDQLDVFLQKETQIFVEKLFDAVNTKSYLPPPEQPSSGSLKVEFFPHQEKDIKKEEITKEEEREKKFSRRLNHSPPQSSSRYRENRSRDERKKDDRSRKRDYDRNPPRRDSYRDRYNRRRGRSRSYSRSRSRSWSKERLRERDRDRSRTRSRSRTRSRERDLVKPKYDLDRTDPLENNYTPVSSVPSISSGHYPVPTLSSTITVIAPTHHGNNTTESWSEFHEDQVDHNSYVRPPMPKKRCRDYDEKGFCMRGDMCPFDHGSDPVVVEDVNLPGMLPFPAQPPVVEGPPPPGLPPPPPILTPPPVNLRPPVPPPGPLPPSLPPVTGPPPPLPPLQPSGMDAPPNSATSSVPTVVTTGIHHQPPPAPPSLFTADTYDTDGYNPEAPSITNTSRPMYRHRVHAQRPNLIGLTSGDMDLPPREKPPNKSSMRIVVDSESRKRTIGSGEPGVPTKKTWFDKPNFNRTNSPGFQKKVQFGNENTKLELRKVPPELNNISKLNEHFSRFGTLVNLQVAYNGDPEGALIQFATYEEAKKAISSTEAVLNNRFIKVYWHREGSTQQLQTTSPKVMQPLVQQPILPVVKQSVKERLGPVPSSTIEPAEAQSASSDLPQNVTKLSVKDRLGFVSKPSVSATEKVLSTSTGLTKTVYNPAALKAAQKTLLVSTSAVDNNEAQKKKQEALKLQQDVRKRKQEILEKHIETQKMLISKLEKNKTMKSEDKAEIMKTLEVLTKNITKLKDEVKAASPGRCLPKSIKTKTQMQKELLDTELDLYKKMQAGEEVTELRRKYTELQLEAAKRGILSSGRGRGIHSRGRGAVHGRGRGRGRGRGVPGHAVVDHRPRALEISAFTESDREDLLPHFAQYGEIEDCQIDDSSLHAVITFKTRAEAEAAAVHGARFKGQDLKLAWNKPVTNISAVETEEVEPDEEEFQEESLVDDSLLQDDDEEEEDNESRSWRR"},{"id":"SEQ_09759","a":"Q8WXE9","g":"STON2","d":"Stonin-2","L":905,"m":[{"c":"WVoF[DEN]-[DEN]","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed copies in the N-terminal S/P-rich disordered region share invariant W1, V2, and F4 anchors, a polar uncharged position 3 (S/Q/T), and a conserved C-terminal acidic/polar tripeptide cap (NEE, EDD, DDN).","i":[[15,21,"WVSFNEE"],[102,108,"WVQFEDD"],[232,238,"WVTFDDN"]]}],"s":"MTTLDHVIATHQSEWVSFNEEPPFPAHSQGGTEEHLPGLSSSPDQSESSSGENHVVDGGSQDHSHSEQDDSSEKMGLISEAASPPGSPEQPPPDLASAISNWVQFEDDTPWASTSPPHQETAETALPLTMPCWTCPSFDSLGRCPLTSESSWTTHSEDTSSPSFGCSYTDLQLINAEEQTSGQASGADSTDNSSSLQEDEEVEMEAISWQASSPAMNGHPAPPVTSARFPSWVTFDDNEVSCPLPPVTSPLKPNTPPSASVIPDVPYNSMGSFKKRDRPKSTLMNFSKVQKLDISSLNRTPSVTEASPWRATNPFLNETLQDVQPSPINPFSAFFEEQERRSQNSSISSTTGKSQRDSLIVIYQDAISFDDSSKTQSHSDAVEKLKQLQIDDPDHFGSATLPDDDPVAWIELDAHPPGSARSQPRDGWPMMLRIPEKKNIMSSRHWGPIFVKLTDTGYLQLYYEQGLEKPFREFKLEICHEISEPRLQNYDENGRIHSLRIDRVTYKEKKKYQPKPAVAHTAEREQVIKLGTTNYDDFLSFIHAVQDRLMDLPVLSMDLSTVGLNYLEEEITVDVRDEFSGIVSKGDNQILQHHVLTRIHILSFLSGLAECRLGLNDILVKGNEIVLRQDIMPTTTTKWIKLHECRFHGCVDEDVFHNSRVILFNPLDACRFELMRFRTVFAEKTLPFTLRTATSVNGAEVEVQSWLRMSTGFSANRDPLTQVPCENVMIRYPVPSEWVKNFRRESVLGEKSLKAKVNRGASFGSTSVSGSEPVMRVTLGTAKYEHAFNSIVWRINRLPDKNSASGHPHCFFCHLELGSDREVPSRFANHVNVEFSMPTTSASKASVRSISVEDKTDVRKWVNYSAHYSYQVALGSIWLMLPTPFVHPTTLPLLFLLAMLTMFAW"},{"id":"SEQ_09765","a":"Q2WGJ9","g":"FER1L6","d":"Fer-1-like protein 6","L":1857,"m":[{"c":"xxφxφxxxxx(x){8,24}[DR][PI]xφxxxx(x){14,21}x[PF]xΩxxxxxφ(x){8,29}xψxxxxφ[DF](x){6,8}φφ[GL](x){5,9}L","u":"86-120","sp":"dispersed","x":"structured_like","cf":"high","why":"Six dispersed ~86-120 aa structured domain repeats sharing conserved hydrophobic beta-strands (xxφxφ, xψxxxxφ[DF], φφ[GL]...L) and internal [DR][PI]xφ and x[PF]xΩxxxxxφ loop/strand motifs separated by variable loops.","i":[[83,168,"YQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQVHLFDKIIKISVFHHKLIGSVLIGSFKVDL"],[245,343,"FYVRLYKAEGLPKMNSSIMANVTKAFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMFPPLCRRVKIQVWDEGSMNDVALATHFIDL"],[824,925,"HVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVVKL"],[992,1085,"YRVEVLFWGVREMKKVQLLSVDRPQALIECGGQGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTINYL"],[1356,1444,"VLIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIGETKIDL"],[1596,1715,"YELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNL"]]}],"s":"MFGLKVKKKRNKAEKGLILANKAAKDSQGDTEALQEEPSHQEGPRGDLVHDDASIFPVPSASPKRRSKLLTKIHDGEVRSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQVHLFDKIIKISVFHHKLIGSVLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTKGYLKCDISVMGKGDVLKTSPKTSDTEEPIEKNLLIPNGFPLERPWARFYVRLYKAEGLPKMNSSIMANVTKAFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMFPPLCRRVKIQVWDEGSMNDVALATHFIDLKKISNEQDGDKGFLPTFGPAWINLYGSPRNHSLMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQESKFSKALKELKLPSKDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIVPEKNEEFLLFGAFFEATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDLLPLLHEGQGDVAHDVPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTFRLHWSNMLEKMADFLEESIEEVRELIKISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLDKKRLTLCWQELEAMCKEAKGIIQQQKKKLSVDEMIHEAQNFVEKIRFLVDEPQHTIPDVFIWMLSNNRRVAYARIASKDLLYSPVAGQMGKHCGKIKTHFLKPPGKRPAGWSVQAKVDVYLWLGSIKHASAILDNLPVGYEAEMSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVVKLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLPPVEPPDITQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIECGGQGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTINYLKQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVEPPPTVVPDSAQAQPAILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKRTIADESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKKDKMLKKKPKDDGIPNLAILQIYDGDLESEFNNFEDWVKTFELFRGKSTEDDHGLDGDRVIGKFKGSFCIYKSPQDSSSEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIGETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHPGKIQIGNQVFSGKTIFTEEDTDETVESYEHLALKVLHSWEDIPEVGCRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENASEETKISIFQQKRVRGWWPFSKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRRIVVGS"},{"id":"SEQ_09778","a":"Q9BY44","g":"EIF2A","d":"Eukaryotic translation initiation factor 2A","L":585,"m":[{"c":"Ω[SC][PK]x[GN]xxφφ[WTL](x){7,16}φxxφxx[KT]","u":"24-33","sp":"dispersed","x":"structured_like","cf":"high","why":"Four well-conserved beta-propeller/WD-like repeat blades sharing an N-terminal aromatic-[SC]-[PK]-x-[GN] turn and hydrophobic beta-strand core followed after a variable 7-16 aa loop by a C-terminal φxxφxx[KT] strand.","i":[[44,67,"FSKDGTLFAWGNGEKVNIISVTNK"],[83,115,"FSPKNTVLATWQPYTTSKDGTAGIPNLQLYDVK"],[322,347,"YSPHGHILVLAGFGNLRGQMEVWDVK"],[365,393,"WCPDGEHILTATCAPRLRVNNGYKIWHYT"]]}],"s":"MAPSTPLLTVRGSEGLYMVNGPPHFTESTVFPRESGKNCKVCIFSKDGTLFAWGNGEKVNIISVTNKGLLHSFDLLKAVCLEFSPKNTVLATWQPYTTSKDGTAGIPNLQLYDVKTGTCLKSFIQKKMQNWCPSWSEDETLCARNVNNEVHFFENNNFNTIANKLHLQKINDFVLSPGPQPYKVAVYVPGSKGAPSFVRLYQYPNFAGPHAALANKSFFKADKVTMLWNKKATAVLVIASTDVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKATIFNLKCDPVFDFGTGPRNAAYYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSILHKYDVPSNAELWQVSWQPFLDGIFPAKTITYQAVPSEVPNEEPKVATAYRPPALRNKPITNSKLHEEEPPQNMKPQSGNDKPLSKTALKNQRKHEAKKAAKQEARSDKSPDLAPTPAPQSTPRNTVSQSISGDPEIDKKIKNLKKKLKAIEQLKEQAATGKQLEKNQLEKIQKETALLQELEDLELGI"},{"id":"SEQ_09781","a":"Q14202","g":"ZMYM3","d":"Zinc finger MYM-type protein 3","L":1370,"m":[{"c":"CxxC(x){18,24}[FL]CxxxCxxx[FY]","u":"32-38","sp":"dispersed","x":"structured_like","cf":"high","why":"Ten closely spaced cysteine-rich zinc-binding repeats (separated by 9-19 aa linkers), each comprising an N-terminal CxxC knuckle, an 18-24 aa internal loop, and an invariant [FL]CxxxCxxx[FY] second knuckle.","i":[[311,343,"CAHCRTPLQKGQTAYQRKGLPQLFCSSSCLTTF"],[353,389,"CTFCKKEIWNTKDSVVAQTGSGGSFHEFCTSVCLSLY"],[409,440,"CSICQKTGEVLHEVSNGSVVHRLCSDSCFSKF"],[451,488,"CDQCGAYIYTKTGSPGPELLFHEGQQKRFCNTTCLGAY"],[498,532,"CVWCKTLCKNFEMLSHVDRNGKTSLFCSLCCTTSY"],[546,578,"CSFCRRSLSDPCYYNKVDRTVYQFCSPSCWTKF"],[591,623,"CHYCHSLFSGKPEVLDWQDQVFQFCCRDCCEDF"],[633,664,"CEHCRQEKLLHEKLRFSGVEKSFCSEGCVLLY"],[676,710,"CITCTYCSQTCQRGVTEQLDGSTWDFCSEDCKSKY"],[720,751,"CHACKRQGKLLETIHWRGQIRHFCNQQCLLRF"]]},{"c":"QxψxψPφxψPIxVPVPMxL","u":19,"sp":"tandem","x":"mixed","cf":"high","why":"Tandem 19-aa internal duplication separated by a 2-residue gap (YC), conserving 10 identical positions (including the PIxVPVPMxL core and N-terminal Q/P anchors) plus four hydrophobic positions.","i":[[863,881,"QVIVLPIPVPIFVPVPMHL"],[884,902,"QKVPVPFSMPIPVPVPMFL"]]}],"s":"MDPSDFPSPFDPLTLPEKPLAGDLPVDMEFGEDLLESQTAPTRGWAPPGPSPSSGALDLLDTPAGLEKDPGVLDGATELLGLGGLLYKAPSPPEVDHGPEGTLAWDAGDQTLEPGPGGQTPEVVPPDPGAGANSCSPEGLLEPLAPDSPITLQSPHIEEEETTSIATARRGSPGQEEELPQGQPQSPNAPPSPSVGETLGDGINSSQTKPGGSSPPAHPSLPGDGLTAKASEKPPERKRSERVRRAEPPKPEVVDSTESIPVSDEDSDAMVDDPNDEDFVPFRPRRSPRMSLRSSVSQRAGRSAVGTKMTCAHCRTPLQKGQTAYQRKGLPQLFCSSSCLTTFSKKPSGKKTCTFCKKEIWNTKDSVVAQTGSGGSFHEFCTSVCLSLYEAQQQRPIPQSGDPADATRCSICQKTGEVLHEVSNGSVVHRLCSDSCFSKFRANKGLKTNCCDQCGAYIYTKTGSPGPELLFHEGQQKRFCNTTCLGAYKKKNTRVYPCVWCKTLCKNFEMLSHVDRNGKTSLFCSLCCTTSYKVKQAGLTGPPRPCSFCRRSLSDPCYYNKVDRTVYQFCSPSCWTKFQRTSPEGGIHLSCHYCHSLFSGKPEVLDWQDQVFQFCCRDCCEDFKRLRGVVSQCEHCRQEKLLHEKLRFSGVEKSFCSEGCVLLYKQDFTKKLGLCCITCTYCSQTCQRGVTEQLDGSTWDFCSEDCKSKYLLWYCKAARCHACKRQGKLLETIHWRGQIRHFCNQQCLLRFYSQQNQPNLDTQSGPESLLNSQSPESKPQTPSQTKVENSNTVRTPEENGNLGKIPVKTRSAPTAPTPPPPPPPATPRKNKAAMCKPLMQNRGVSCKVEMKSKGSQTEEWKPQVIVLPIPVPIFVPVPMHLYCQKVPVPFSMPIPVPVPMFLPTTLESTDKIVETIEELKVKIPSNPLEADILAMAEMIAEAEELDKASSDLCDLVSNQSAEGLLEDCDLFGPARDDVLAMAVKMANVLDEPGQDLEADFPKNPLDINPSVDFLFDCGLVGPEDVSTEQDLPRTMRKGQKRLVLSESCSRDSMSSQPSCTGLNYSYGVNAWKCWVQSKYANGETSKGDELRFGPKPMRIKEDILACSAAELNYGLAQFVREITRPNGERYEPDSIYYLCLGIQQYLLENNRMVNIFTDLYYLTFVQELNKSLSTWQPTLLPNNTVFSRVEEEHLWECKQLGVYSPFVLLNTLMFFNTKFFGLQTAEEHMQLSFTNVVRQSRKCTTPRGTTKVVSIRYYAPVRQRKGRDTGPGKRKREDEAPILEQRENRMNPLRCPVKFYEFYLSKCPESLRTRNDVFYLQPERSCIAESPLWYSVIPMDRSMLESMLNRILAVREIYEELGRPGEEDLD"},{"id":"SEQ_09793","a":"Q92504","g":"SLC39A7","d":"Zinc transporter SLC39A7","L":469,"m":[{"c":"xHxH[GR][HY][ST]HE[DS]φ[HWY]H","u":13,"sp":"tandem","x":"disordered_like","cf":"high","why":"Four contiguous copies in the histidine-rich N-terminal disordered region (residues 44-103, separated by 0 or 4 aa GH[ST]H sub-linkers) pair two xHxH tetrapeptides with a strongly anchored E[DS]φ[HWY]H motif that distinguishes this repeat from unanchored histidine tracts elsewhere in the sequence.","i":[[44,56,"GHSHRHSHEDFHH"],[61,73,"AHGHGHTHESIWH"],[78,90,"DHDHGHSHEDLHH"],[91,103,"GHSHGYSHESLYH"]]}],"s":"MARGLGAPHWVAVGLLTWATLGLLVAGLGGHDDLHDDLQEDFHGHSHRHSHEDFHHGHSHAHGHGHTHESIWHGHTHDHDHGHSHEDLHHGHSHGYSHESLYHRGHGHDHEHSHGGYGESGAPGIKQDLDAVTLWAYALGATVLISAAPFFVLFLIPVESNSPRHRSLLQILLSFASGGLLGDAFLHLIPHALEPHSHHTLEQPGHGHSHSGQGPILSVGLWVLSGIVAFLVVEKFVRHVKGGHGHSHGHGHAHSHTRGSHGHGRQERSTKEKQSSEEEEKETRGVQKRRGGSTVPKDGPVRPQNAEEEKRGLDLRVSGYLNLAADLAHNFTDGLAIGASFRGGRGLGILTTMTVLLHEVPHEVGDFAILVQSGCSKKQAMRLQLLTAVGALAGTACALLTEGGAVGSEIAGGAGPGWVLPFTAGGFIYVATVSVLPELLREASPLQSLLEVLGLLGGVIMMVLIAHLE"},{"id":"SEQ_09809","a":"Q00975","g":"CACNA1B","d":"Voltage-dependent N-type calcium channel subunit alpha-1B","L":2339,"m":[{"c":"[PSY]F[EY]φφψψxxψφφ[NS][CST]ψxψφφx(x){18,21}Fx[GS]ψFx[FMT]E[ACM][GSV]ψKψφ[ADG]φG(x){3,7}YφR[DNS]xΩN[CIV]φDF[GIV][TV]ψ[LSV][GT][AGS]ψ(x){9,16}ψ[KRS]xLRφφRφφR[ILP]φK[LTV]x[KRS]xx[PSY][KST]ψ[KQR]xψφx[CST]φψ[KNQ][AS]φ[KV]xψ[ILP]xψ[CGL]φψφφφFφφψφφφψ[AG]ψ[EQ]φΩ[GKM][GN](x){11,48}[HN]Ω[DR][NT]φ[LP]xAψψ[LT]ψF[QRT]xxT[GM]E[ADG]Wxxψψ(x){12,23}[SWY]φΩΩψ[PSV]φ[FIT]φφ[CFG][NPS]Ω[FLT]φψNψφψ[AG]ψφx[DGI][ENT]φ","u":"230-269","sp":"dispersed","x":"structured_like","cf":"high","why":"Four large homologous six-segment hydrophobic transmembrane domain repeats separated by long hydrophilic linkers, sharing invariant anchors across all copies including F in S1, F/E/K/G in S2, Y/R/N/D/F in S3, a gapless 60-aa S4-S5 module with periodic RxxR/RxxK voltage-sensor-like basic residues, A/F/T/E/W in the pore segment, and N in S6.","i":[[96,359,"PFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF"],[483,712,"SFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNL"],[1151,1419,"YFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITF"],[1472,1711,"PFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF"]]},{"c":"[EGP]xRR[AH][HR][AHR][HR][GHR]","u":9,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Five dispersed copies of a 9-residue basic/histidine-rich motif within the central disordered linker between the second and third structured domains, anchored by an invariant RR dyad, conserved His/Arg alternating positions, and an N-terminal [EGP] cap.","i":[[847,855,"PPRRHHRHR"],[914,922,"GGRRHHRRG"],[931,939,"EPRRHRAHR"],[952,960,"GERRARHRG"],[975,983,"PARRHRARH"]]},{"c":"E[AT][TV]EK","u":5,"sp":"tandem","x":"disordered_like","cf":"medium","why":"Three head-to-tail tandem 5-aa repeats immediately C-terminal to the basic/His-rich cluster in the central disordered linker, defined by invariant Glu anchors at positions 1 and 4, a C-terminal Lys at position 5, and constrained [AT][TV] core residues.","i":[[990,994,"EAVEK"],[995,999,"ETTEK"],[1000,1004,"EATEK"]]}],"s":"MVRFGDELGGRYGGPGGGERARGGGAGGAGGPGPGGLQPGQRVLYKQSIAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLDRPLVVELGRDGARGPVGGKARPEAAEAPEGVDPPRRHHRHRDKDKTPAAGDQDRAEAPKAESGEPGAREERPRPHRSHSKEAAGPPEARSERGRGPGPEGGRRHHRRGSPEEAAEREPRRHRAHRHQDPSKECAGAKGERRARHRGGPRAGPREAESGEEPARRHRARHKAQPAHEAVEKETTEKEATEKEAEIVEADKEKELRNHQPREPHCDLETSGTVTVGPMHTLPSTCLQKVEEQPEDADNQRNVTRMGSQPPDPNTIVHIPVMLTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQMQSITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGPHPQGSGSVNGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPLSQPLAPGSRIGSDPYLGQRLDSEASVHALPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSSGGRARHSYHHPDQDHWC"},{"id":"SEQ_09811","a":"Q9Y5I1","g":"PCDHA11","d":"Protocadherin alpha-11","L":949,"m":[{"c":"(x){12,23}xxφxxxx[AV]xDx[DG](x){9,10}L(x){22,27}x[LI]Dx[EA](x){10,15}[IAV]xD(x){9,13}Vx[VIL](x){7,10}","u":"104-111","sp":"tandem","x":"structured_like","cf":"high","why":"Six head-to-tail ~104-111 aa structured domain repeats sharing conserved [AV]xDx[DG], L, x[LI]Dx[EA], [IAV]xD, and Vx[VIL] motifs, with copies 1-5 terminating in a conserved D[VIE]NDNxPx[FVL] calcium-binding-like signature and copy 6 diverging at its C-terminal juxtamembrane end.","i":[[30,133,"QLHYSVSEEAKHGTFVGRIAQDLGLELAELVQRLFRVASKTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVFHVNVEVKDINDNPPVF"],[134,242,"SLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYFSLDSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDPEF"],[243,349,"DKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGRHLFTLDQNNGEVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEV"],[350,454,"AVTSLSLPVREDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAF"],[455,564,"AQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLSSNVTLQVFVLDENDNAPAL"],[565,675,"LATQAGSAGGAVNKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAP"]]}],"s":"MFGFQRRGLGTPRLQLWLLLLEFWEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELVQRLFRVASKTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVFHVNVEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYFSLDSPTNGKQIKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDPEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGRHLFTLDQNNGEVRVNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVREDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGSRIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRTLAGAASPEAALVDVNVYLIIAICVVSSLLVLTLLLYTALWWSATPTEGACAPGKPTLVCSRAVGSWSYSQQRRQRVCSEEGPPKTDLMAFSPSLPLGLNKEEEGERQEPGSNHPGQPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ"},{"id":"SEQ_09814","a":"Q9UQ16","g":"DNM3","d":"Dynamin-3","L":869,"m":[{"c":"[AP]Px[VS]PxR[PR]","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four non-overlapping 8-aa proline/arginine-rich motifs clustered in the C-terminal disordered tail (residues 809-858), anchored by invariant P2, P5, and R7 positions plus conserved [AP]1, [VS]4, and [PR]8 choices.","i":[[808,815,"APPVPFRP"],[831,838,"PPQVPSRP"],[842,849,"PPSVPSRR"],[850,857,"PPPSPTRP"]]}],"s":"MGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVTSKAEYAEFLHCKGKKFTDFDEVRLEIEAETDRVTGMNKGISSIPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLILAVTPANTDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYVGVVNRSQKDIDGKKDIKAAMLAERKFFLSHPAYRHIADRMGTPHLQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIEHEVEAYKNFKPEDPTRKTKALLQMVQQFAVDFEKRIEGSGDQVDTLELSGGAKINRIFHERFPFEIVKMEFNEKELRREISYAIKNIHGIRTGLFTPDMAFEAIVKKQIVKLKGPSLKSVDLVIQELINTVKKCTKKLANFPRLCEETERIVANHIREREGKTKDQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHKKTTVGNQGTNLPPSRQIVIRKGWLTISNIGIMKGGSKGYWFVLTAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKSFMSSKHIFALFNTEQRNVYKDYRFLELACDSQEDVDSWKASLLRAGVYPDKSVAENDENGQAENFSMDPQLERQVETIRNLVDSYMSIINKCIRDLIPKTIMHLMINNVKDFINSELLAQLYSSEDQNTLMEESAEQAQRRDEMLRMYQALKEALGIIGDISTATVSTPAPPPVDDSWIQHSRRSPPPSPTTQRRPTLSAPLARPTSGRGPAPAIPSPGPHSGAPPVPFRPGPLPPFPSSSDSFGAPPQVPSRPTRAPPSVPSRRPPPSPTRPTIIRPLESSLLD"},{"id":"SEQ_09815","a":"Q96C55","g":"ZNF524","d":"Zinc finger protein 524","L":264,"m":[{"c":"P[HYF]xC[PK]ψCxxxFxxxxxLx[RH]H(x){3,4}Hxxxx","u":"28-29","sp":"tandem","x":"structured_like","cf":"high","why":"Four head-to-tail 28-29 aa C2H2-type repeats anchored by invariant P1, C4, C7, F11, L17, H20, and a second H separated by 3-4 residues, with conserved [HYF]2, [PK]5, aliphatic ψ6, and [RH]19 positions.","i":[[113,140,"PHFCPVCLRAFPYLSDLERHSISHSELK"],[141,168,"PHQCKVCGKTFKRSSHLRRHCNIHAGLR"],[169,196,"PFRCPLCPRRFREAGELAHHHRVHSGER"],[197,225,"PYQCPICRLRFTEANTLRRHAKRKHPEAM"]]}],"s":"MDTPSPDPLPSPLPGEEEKPLALSPPVPRGRRGRRPGGATSSNRTLKASLPRKRGRPPKSGQEPPLVQVQGVTAPVGSSGGSDLLLIDDQGVPYTVSEGSAAGPEGSGPRKAPHFCPVCLRAFPYLSDLERHSISHSELKPHQCKVCGKTFKRSSHLRRHCNIHAGLRPFRCPLCPRRFREAGELAHHHRVHSGERPYQCPICRLRFTEANTLRRHAKRKHPEAMGVPLCAPDPGSEPPWDEEGIPATAGAEEEEETEGKGEPA"},{"id":"SEQ_09820","a":"Q5T7N2","g":"L1TD1","d":"LINE-1 type transposase domain-containing protein 1","L":865,"m":[{"c":"KExψψ+ASREx+xψxxxGxxψxLxADLSxxTLDφxxxWSNVFxψLxExxFxP+φLxxφKψAFxxxGxxKxFxxψxxφRxΩφxxxxoψ+ELL","u":91,"sp":"dispersed","x":"structured_like","cf":"high","why":"Strongly conserved 91-aa internal domain duplication (35% ungapped sequence identity plus extensive hydrophobic/polar conservation) anchored by invariant KExxx+ASRE, LxADLSxxTLD, WSNVF, P+φLxxφKψAF, GxxKxF, and ELL motifs, separated by a ~456-aa central region.","i":[[223,313,"KEEVLKASREEKVLMDEGAVLTLVADLSSATLDISKQWSNVFNILRENDFEPKFLCEVKLAFKCDGEIKTFSDLQSLRKFASQKSSVKELL"],[770,860,"KEKIIRASRERREITYQGTRIRLTADLSLDTLDARSKWSNVFKVLLEKGFNPRILYPAKMAFDFRGKTKVFLSIEEFRDYVLHMPTLRELL"]]},{"c":"[ATP]SG[LM]E--E","u":8,"sp":"tandem","x":"disordered_like","cf":"high","why":"Five contiguous 8-aa repeats in the central acidic disordered region anchored by a conserved SG[LM] core, an N-terminal [ATP] choice, and a C-terminal E--E acidic tract, separated by 0-3 acidic linker residues.","i":[[391,398,"ASGMEDDE"],[400,407,"TSGLEEEE"],[410,417,"PSGLEEEE"],[421,428,"ASGLEEDE"],[429,436,"ASGLEEEE"]]}],"s":"MSDVSTSVQSKFARLAKKKENITYMKREQLTETDKDIAPVLDLKCKDVSAIMNKFKVLMEIQDLMFEEMRETLKNDLKAVLGGKATIPEVKNSENSSSRTEFQQIINLALQKTGMVGKIEGENSKIGDDNENLTFKLEVNELSGKLDNTNEYNSNDGKKLPQGESRSYEVMGSMEETLCNIDDRDGNRNVHLEFTERESRKDGEDEFVKEMREERKFQKLKNKEEVLKASREEKVLMDEGAVLTLVADLSSATLDISKQWSNVFNILRENDFEPKFLCEVKLAFKCDGEIKTFSDLQSLRKFASQKSSVKELLKDVLPQKEEINQGGRKYGIQEKRDKTLIDSKHRAGEITSDGLSFLFLKEVKVAKPEEMKNLETQEEEFSELEELDEEASGMEDDEDTSGLEEEEEEPSGLEEEEEEEASGLEEDEASGLEEEEEQTSEQDSTFQGHTLVDAKHEVEITSDGMETTFIDSVEDSESEEEEEGKSSETGKVKTTSLTEKKASRRQKEIPFSYLVGDSGKKKLVKHQVVHKTQEEEETAVPTSQGTGTPCLTLCLASPSKSLEMSHDEHKKHSHTNLSISTGVTKLKKTEEKKHRTLHTEELTSKEADLTEETEENLRSSVINSIREIKEEIGNLKSSHSGVLEIENSVDDLSSRMDILEERIDSLEDQIEEFSKDTMQMTKQIISKERQRDIEERSRSCNIRLIGIPEKESYENRAEDIIKEIIDENFAELKKGSSLEIVSACRVPSKIDEKRLTPRHILVKFWNSSDKEKIIRASRERREITYQGTRIRLTADLSLDTLDARSKWSNVFKVLLEKGFNPRILYPAKMAFDFRGKTKVFLSIEEFRDYVLHMPTLRELLGNNIP"},{"id":"SEQ_09825","a":"O60828","g":"PQBP1","d":"Polyglutamine-binding protein 1","L":265,"m":[{"c":"[GS][HY]-KxDR","u":7,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Seven 7-aa repeats in the central charged disordered region featuring invariant K (pos 4), D (pos 6), and R (pos 7) anchors alongside strictly constrained [GS], [HY], and acidic [DE] positions, arranged as five head-to-tail tandem copies (preceded by a degenerate AEEKLDR unit) plus two C-terminal copies separated by 4-aa and 12-aa R/E/D linkers.","i":[[106,112,"SHDKSDR"],[113,119,"GHDKSDR"],[120,126,"SHEKLDR"],[127,133,"GHDKSDR"],[134,140,"GHDKSDR"],[145,151,"GYDKVDR"],[164,170,"GYDKADR"]]}],"s":"MPLPVALQTRLAKRGILKHLEPEPEEEIIAEDYDDDPVDYEATRLEGLPPSWYKVFDPSCGLPYYWNADTDLVSWLSPHDPNSVVTKSAKKLRSSNADAEEKLDRSHDKSDRGHDKSDRSHEKLDRGHDKSDRGHDKSDRDRERGYDKVDRERERDRERDRDRGYDKADREEGKERRHHRREELAPYPKSKKAVSRKDEELDPMDPSSYSDAPRGTWSTGLPKRNEAKTGADTTAAGPLFQQRPYPSPGAVLRANAEASRTKQQD"},{"id":"SEQ_09827","a":"Q96PV0","g":"SYNGAP1","d":"Ras/Rap GTPase-activating protein SynGAP","L":1343,"m":[{"c":"[RG][DGR]LNSS","u":6,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Three copies of an R-containing LNSS motif cluster within a ~100-aa central disordered region; the first two copies are embedded in a strongly conserved 14-aa head-to-tail tandem duplication (MMRDLNSSIDLQSF / MARGLNSSMDMARL) with a third copy dispersed downstream.","i":[[761,766,"RDLNSS"],[775,780,"RGLNSS"],[853,858,"GRLNSS"]]}],"s":"MSRSRASIHRGSIPAMSYAPFRDVRGPSMHRTQYVHSPYDRPGWNPRFCIISGNQLLMLDEDEIHPLLIRDRRSESSRNKLLRRTVSVPVEGRPHGEHEYHLGRSRRKSVPGGKQYSMEGAPAAPFRPSQGFLSRRLKSSIKRTKSQPKLDRTSSFRQILPRFRSADHDRARLMQSFKESHSHESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEFCFEVTTSSGTKCFACRSAAERDKWIENLQRAVKPNKDNSRRVDNVLKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSASGDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRMLCAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTASSLAEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAERGREDIADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSMQQFLYEISNLDTLTNSSSFEGYIDLGRELSTLHALLWEVLPQLSKEALLKLGPLPRLLNDISTALRNPNIQRQPSRQSERPRPQPVVLRGPSAEMQGYMMRDLNSSIDLQSFMARGLNSSMDMARLPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKMLSVNKSVSMLDLQGDGPGGRLNSSSVSNLAAVGDLLHSSQASLTAALGLRPAPAGRLSQGSGSSITAAGMRLSQMGVTTDGVPAQQLRIPLSFQNPLFHMAADGPGPPGGHGGGGGHGPPSSHHHHHHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEFGPSGTDFTRRQLSLQDNLQHMLSPPQITIGPQRPAPSGPGGGSGGGSGGGGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPARPRQQSLSKEGSIGGSGGSGGGGGGGLKPSITKQHSQTPSTLNPTMPASERTVAWVSNMPHLSADIESAHIEREEYKLKEYSKSMDESRLDRVKEYEEEIHSLKERLHMSNRKLEEYERRLLSQEEQTSKILMQYQARLEQSEKRLRQQQAEKDSQIKSIIGRLMLVEEELRRDHPAMAEPLPEPKKRLLDAQERQLPPLGPTNPRVTLAPPWNGLAPPAPPPPPRLQITENGEFRNTADH"},{"id":"SEQ_09844","a":"Q6ZSN1","g":"YI023_HUMAN","d":"Putative uncharacterized protein FLJ45355","L":163,"m":[{"c":"[MI]GV[PL][RI][AD]R[EG]GRGAGSQSxPRGx[CS][LF]xPx[RL][WG]GS","u":30,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three highly conserved 30-aa repeats sharing 17 strictly invariant positions (including the central GRGAGSQSxPRG core and N/C-terminal GV..R / P...GS anchors) separated by variable 23-aa and 50-aa P/G-rich linkers that also share a duplicated GVPPPPA segment before copies 2 and 3.","i":[[1,30,"MGVPRAREGRGAGSQSPPRGRCLHPFRWGS"],[54,83,"MGVPRDRGGRGAGSQSTPRGGCLLPPRLGS"],[134,163,"IGVLIARGGRGAGSQSLPRGWSFTPLRWGS"]]}],"s":"MGVPRAREGRGAGSQSPPRGRCLHPFRWGSQDRGRGEGLALSPLLPGVPPPPAMGVPRDRGGRGAGSQSTPRGGCLLPPRLGSQQPAGEEGLVLSPRLAGDASPCCDGSPKSQGVKRGWLSVPTSRGVPPPPAIGVLIARGGRGAGSQSLPRGWSFTPLRWGS"},{"id":"SEQ_09853","a":"Q96QS3","g":"ARX","d":"Homeobox protein ARX","L":562,"m":[{"c":"D[DE]EEELLE","u":8,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three clustered 8-aa repeats within an acidic disordered region (positions 224-252, with a 5-aa DEEDE stutter after the first unit, head-to-tail tandem spacing between units 2 and 3, and an immediately adjacent divergent fourth unit DDARALLK) anchored by an invariant dileucine (LL) dyad and fixed flanking D/E positions.","i":[[225,232,"DDEEELLE"],[238,245,"DEEEELLE"],[246,253,"DDEEELLE"]]}],"s":"MSNQYQEEGCSERPECKSKSPTLLSSYCIDSILGRRSPCKMRLLGAAQSLPAPLTSRADPEKAVQGSPKSSSAPFEAELHLPPKLRRLYGPGGGRLLQGAAAAAAAAAAAAAAAATATAGPRGEAPPPPPPTARPGERPDGAGAAAAAAAAAAAAWDTLKISQAPQVSISRSKSYRENGAPFVPPPPALDELGGPGGVTHPEERLGVAGGPGSAPAAGGGTGTEDDEEELLEDEEDEDEEEELLEDDEEELLEDDARALLKEPRRCPVAATGAVAAAAAAAVATEGGELSPKEELLLHPEDAEGKDGEDSVCLSAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGAQTHPPGLPFPGPLSATHPLSPYLDASPFPPHHPALDSAWTAAAAAAAAAFPSLPPPPGSASLPPSGAPLGLSTFLGAAVFRHPAFISPAFGRLFSTMAPLTSASTAAALLRQPTPAVEGAVASGALADPATAAADRRASSIAALRLKAKEHAAQLTQLNILPGTSTGKEVC"},{"id":"SEQ_09864","a":"O15016","g":"TRIM66","d":"Tripartite motif-containing protein 66","L":1351,"m":[{"c":"[QK]xx[PSA][SNP][LV]xxxxx","u":11,"sp":"tandem","x":"disordered_like","cf":"high","why":"Ten head-to-tail 11-residue repeats in the central proline/serine/glutamine-rich disordered region (residues 761-870), anchored by N-terminal Q (9/10 copies), an internal [PSA][SNP][LV] core (predominantly PSL/SSL/PNL with aliphatic V/M/I immediately upstream in 9/10 copies), and exact 11-aa register.","i":[[761,771,"QSVSNLTAGAP"],[772,782,"QAVPSLLSAPP"],[783,793,"KMVSSLTSVQN"],[794,804,"QAMPSLTTSHL"],[805,815,"QTVPSLVHSTF"],[816,826,"QSMPNLISDSP"],[827,837,"QAMASLASDHP"],[838,848,"QAGPSLMSGHT"],[849,859,"QAVPSLATCPL"],[860,870,"QSIPPVSDMQP"]]}],"s":"MSFMGLPLAGQKHCPKSGQMEAMVMTCSLCHQDLPGMGSHLLSCQHLLRKDCFQGLIQELGQIAKAHETVADELISCPGCERVYLTRDVTEHFFLHCVPTEQPKMARNCSECKEKRAAHILCTYCNRWLCSSCTEEHRHSPVPGGPFFPRAQKGSPGVNGGPGDFTLYCPLHTQEVLKLFCETCDMLTCHSCLVVEHKEHRCRHVEEVLQNQRMLLEGVTTQVAHKKSSLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEELEGITNERKRKLEQQLQSIMVLNRQFEHVQNFINWAVCSKTSVPFLFSKELIVFQMQRLLETSCNTDPGSPWSIRFTWEPNFWTKQLASLGCITTEGGQMSRADAPAYGGLQGSSPFYQSHQSPVAQQEALSHPSHKFQSPAVCSSSVCCSHCSPVSPSLKGQVPPPSIHPAHSFRQPPEMVPQQLGSLQCSALLPREKELACSPHPPKLLQPWLETQPPVEQESTSQRLGQQLTSQPVCIVPPQDVQQGAHAQPTLQTPSIQVQFGHHQKLKLSHFQQQPQQQLPPPPPPLPHPPPPLPPPPQQPHPPLPPSQHLASSQHESPPGPACSQNMDIMHHKFELEEMQKDLELLLQAQQPSLQLSQTKSPQHLQQTIVGQINYIVRQPAPVQSQSQEETLQATDEPPASQGSKPALPLDKNTAAALPQASGEETPLSVPPVDSTIQHSSPNVVRKHSTSLSIMGFSNTLEMELSSTRLERPLEPQIQSVSNLTAGAPQAVPSLLSAPPKMVSSLTSVQNQAMPSLTTSHLQTVPSLVHSTFQSMPNLISDSPQAMASLASDHPQAGPSLMSGHTQAVPSLATCPLQSIPPVSDMQPETGSSSSSGRTSGSLCPRDGADPSLENALCKMESEDSTRFTDLLGQGPIVPGLDAPKDLAIPSELEEPINLSVKKPPLAPVVSTSTALQQYQNPKECENFEQGALELDAKENQSIRAFNSEHKIPYVRLERLKICAASSGEMPVFKLKPQKNDQDGSFLLIIECGTESSSMSIKVSQDRLSEATQAPGLEGRKVTVTSLAGQRPPEVEGTSPEEHRLIPRTPGAKKGPPAPIENEDFCAVCLNGGELLCCDRCPKVFHLSCHVPALLSFPGGEWVCTLCRSLTQPEMEYDCENACYNQPGMRASPGLSMYDQKKCEKLVLSLCCNNLSLPFHEPVSPLARHYYQIIKRPMDLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFFEGWLKEIYPEKRFAQPRQEDSDSEEVSSESGCSTPQGFPWPPYMQEGIQPKRRRRHMENERAKRMSFRLANSISQV"},{"id":"SEQ_09866","a":"Q9UDT6","g":"CLIP2","d":"CAP-Gly domain-containing linker protein 2","L":1046,"m":[{"c":"DxxLGD(x){9,14}GVVxYψGETxFAxGxWxGVxLD-PψGKNDGAV[GA]GxRYFxCP[AP]xxGψFxxxxKψxR","u":"70-75","sp":"dispersed","x":"structured_like","cf":"high","why":"Two strongly conserved ~70-75 aa globular domain repeats in the N-terminal region separated by a 70-aa serine-rich disordered linker, sharing an N-terminal DxxLGD motif, a short variable loop (9 vs 14 aa), and an un-gapped 55-aa C-terminal core with 34/55 identical positions including GKNDGAV, GVVxYψGETxFA, W, RYF, and CP.","i":[[73,147,"DDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTR"],[218,287,"DLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIR"]]}],"s":"MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAAPEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQNLSLHSGTATPPLTSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDRSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQEDKH"},{"id":"SEQ_09879","a":"Q86YP4","g":"GATAD2A","d":"Transcriptional repressor p66-alpha","L":633,"m":[{"c":"[PM]PPLVRG[AGT]Q[NQ]","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three dispersed copies in a proline/polar-rich central disordered segment anchored by an invariant PPLVRG core and C-terminal Q[NQ] amide pair separated by a small residue ([AGT]).","i":[[190,199,"PPPLVRGTQN"],[220,229,"PPPLVRGGQQ"],[244,253,"MPPLVRGAQQ"]]}],"s":"MTEEACRTRSQKRALERDPTEDDVESKKIKMERGLLASDLNTDGDMRVTPEPGAGPTQGLLRATEATAMAMGRGEGLVGDGPVDMRTSHSDMKSERRPPSPDVIVLSDNEQPSSPRVNGLTTVALKETSTEALMKSSPEERERMIKQLKEELRLEEAKLVLLKKLRQSQIQKEATAQKPTGSVGSTVTTPPPLVRGTQNIPAGKPSLQTSSARMPGSVIPPPLVRGGQQASSKLGPQASSQVVMPPLVRGAQQIHSIRQHSSTGPPPLLLAPRASVPSVQIQGQRIIQQGLIRVANVPNTSLLVNIPQPTPASLKGTTATSAQANSTPTSVASVVTSAESPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEEVVQNLLETQGRMSAATVLSREPYMCAQCKTDFTCRWREEKSGAIMCENCMTTNQKKALKVEHTSRLKAAFVKALQQEQEIEQRLLQQGTAPAQAKAEPTAAPHPVLKQVIKPRRKLAFRSGEARDWSNGAVLQASSQLSRGSATTPRGVLHTFSPSPKLQNSASATALVSRTGRHSERTVSAGKGSATSNWKKTPLSTGGTLAFVSPSLAVHKSSSAVDRQREYLLDMIPPRSIPQSATWK"},{"id":"SEQ_09881","a":"Q76KD6","g":"SPATC1","d":"Speriolin","L":591,"m":[{"c":"G[PT][AV][AP]xS[LQ]SSPL","u":11,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three non-overlapping copies in a proline/serine/threonine-rich disordered region sharing an invariant N-terminal G, conserved small/aliphatic positions ([PT][AV][AP]), and an invariant C-terminal SSPL motif.","i":[[127,137,"GPAPTSQSSPL"],[173,183,"GPVAMSQSSPL"],[189,199,"GTVAVSLSSPL"]]},{"c":"P[LS]TGTL[AST][PST][LS][LS]","u":10,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three non-overlapping copies interleaved with the G-x4-S-x-SSPL motifs in the same disordered region, anchored by invariant P and TGTL positions flanked by constrained [LS] and small polar choices.","i":[[116,125,"PLTGTLSTLL"],[148,157,"PLTGTLASSL"],[160,169,"PSTGTLTPSS"]]}],"s":"MSLLTNYEGLRHQIERLVRENEELKKLVRLIRENHELKSAIKTQAGGLGISGFTSGLGEATAGLSSRQNNGVFLPPSPAVANERVLEEVGIMALAPLAEMLTSLQPSATPGSLMSPLTGTLSTLLSGPAPTSQSSPLTSFLTSPIAGPLTGTLASSLGLPSTGTLTPSSLVAGPVAMSQSSPLIAPVMGTVAVSLSSPLLSSTATPPGVSQNLLANPMSNLVLPEAPRLRLAEPLRGGPTGPQSPACVVPTATTKVPLSTEPPQSTQDPEPLSMAFAGAPLQTSTPIGAMGTPAPKTAFSFNTSDTQAQPSAAQEQVVPASVPTSPTTSPTVTVLASAPALAPQVATSYTPSSTTHIAQGAPHPPSRMHNSPTQNLPVPHCPPHNAHSPPRTSSSPASVNDSRGPRTTEPSTKSMMEVERKLAHRKTSKFPENPRESKQLAWERLVGEIAFQLDRRILSSIFPERVRLYGFTVSNIPEKIIQASLNPSDHKLDEKLCQRLTQRYVSVMNRLQSLGYNGRVHPALTEQLVNAYGILRERPELAASEGGPYTVDFLQRVVVETVHPGMLADALLLLSCLSQLAHDDGKPMFIW"},{"id":"SEQ_09883","a":"Q8IWV1","g":"LAX1","d":"Lymphocyte transmembrane adapter 1","L":398,"m":[{"c":"DY[EV]N[MV]x[AGT][AL]","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed copies across the C-terminal disordered region anchored by invariant DY and N positions, strictly conserved [EV] and aliphatic [MV] core positions, and a C-terminal [AGT][AL] extension.","i":[[192,199,"DYVNVPTA"],[267,274,"DYVNMTGL"],[293,300,"DYENVPAA"],[372,379,"DYENVLTA"]]}],"s":"MDGVTPTLSTIRGRTLESSTLHVTPRSLDRNKDQITNIFSGFAGLLAILLVVAVFCILWNWNKRKKRQVPYLRVTVMPLLTLPQTRQRAKNIYDILPWRQEDLGRHESRSMRIFSTESLLSRNSESPEHVPSQAGNAFQEHTAHIHATEYAVGIYDNAMVPQMCGNLTPSAHCINVRASRDCASISSEDSHDYVNVPTAEEIAETLASTKSPSRNLFVLPSTQKLEFTEERDEGCGDAGDCTSLYSPGAEDSDSLSNGEGSSQISNDYVNMTGLDLSAIQERQLWVAFQCCRDYENVPAADPSGSQQQAEKDVPSSNIGHVEDKTDDPGTHVQCVKRTFLASGDYADFQPFTQSEDSQMKHREEMSNEDSSDYENVLTAKLGGRDSEQGPGTQLLPDE"},{"id":"SEQ_09888","a":"Q5T619","g":"ZNF648","d":"Zinc finger protein 648","L":568,"m":[{"c":"+[GPR][FY]xCxxC[DG]xx[FY]xxxxxxxxH(x){3,4}Hx[GNT]x","u":"28-29","sp":"tandem","x":"structured_like","cf":"high","why":"Ten head-to-tail tandem repeats of 28-29 residues in the C-terminal half, defined by invariant CxxC and H(x){3,4}H pairs, conserved [FY] aromatic positions, and a conserved +[GPR][FY] N-terminal linker.","i":[[277,304,"KRYACELCGKAYSHRGTLQQHRRLHTGE"],[305,332,"RPYQCSFCDKAYTWSSDHRKHIRTHTGE"],[333,361,"KPYPCPDCGKAFVRSSDLRKHQRNMHSNN"],[362,389,"KPFPCSECGLTFNKPLSLLRHQRTHLGA"],[390,417,"KPFRCPACDREFAVASRMVEHQRVHSGE"],[418,445,"RPFPCPTCGKCFTKSSNLSEHQTLHTGQ"],[446,473,"RPFKCADCGVAFAQPSRLVRHQRIHTGE"],[474,501,"RPFPCTQCGQAFARSSTLKRHQQIHSGE"],[502,529,"KGFLCAECGRAFRIASELAQHIRMHNGE"],[530,557,"RPYQCEDCGQAFTRSNHLQRHRAKHGTC"]]}],"s":"MAQVDSQDRWGEASPLSSLTEEAHDTQMLSMNLESDDEDGGEAEKEGTADPVACPRGSSPVTHENPDLPWPHPLGKEEEKFSDSSSAGGMGQKPVEMSGKASWSRDVTKINETQGSPGASRALGSLPSGLAHKLLGQMQPLGDRLPAGDDGYSGANQDAVLDVPPSFPSNGKYLCAHKSVDTSAGNSSLLCFPRPGSNWDLPTQETHTPAQASATPASLAAAVLAKARNSRKVQNQAGRREGGEAEARPYRCLRGGRAFQKPSKPLSPAETRGGAAKRYACELCGKAYSHRGTLQQHRRLHTGERPYQCSFCDKAYTWSSDHRKHIRTHTGEKPYPCPDCGKAFVRSSDLRKHQRNMHSNNKPFPCSECGLTFNKPLSLLRHQRTHLGAKPFRCPACDREFAVASRMVEHQRVHSGERPFPCPTCGKCFTKSSNLSEHQTLHTGQRPFKCADCGVAFAQPSRLVRHQRIHTGERPFPCTQCGQAFARSSTLKRHQQIHSGEKGFLCAECGRAFRIASELAQHIRMHNGERPYQCEDCGQAFTRSNHLQRHRAKHGTCKKEPIPSSSDE"},{"id":"SEQ_09890","a":"P51587","g":"BRCA2","d":"Breast cancer type 2 susceptibility protein","L":3418,"m":[{"c":"Fx[TSI][AS][SHC][GNS][KRT]xxxψ[SAL]xxxφxxx[KRV]xφ[FL]x[DEQ]","u":25,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Eight ungapped 25-residue repeats are dispersed across the central disordered region (~1000-2085 aa), separated by variable 50-190 aa polar linkers. Every copy shares an invariant N-terminal F anchor followed by a conserved [TSI][AS][SHC][GNS][KRT] (predominantly TASGK) box and a phased hydrophobic/basic C-terminal segment (ψ[SAL]xxxφxxx[KRV]xφ[FL]x[DEQ]).","i":[[1009,1033,"FRTASNKEIKLSEHNIKKSKMFFKD"],[1219,1243,"FYSAHGTKLNVSTEALQKAVKLFSD"],[1428,1452,"FQTASGKNISVAKESFNKIVNFFDQ"],[1524,1548,"FHTASGKKVKIAKESLDKVKNLFDE"],[1671,1695,"FYTSCSRKTSVSQTSLLEAKKWLRE"],[1844,1868,"FRIASGKIVCVSHETIKKVKDIFTD"],[1978,2002,"FSTASGKSVQVSDASLQNARQVFSE"],[2058,2082,"FSTASGKQVSILESSLHKVKGVLEE"]]}],"s":"MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPNLFKTPQRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTVKTKMDQADDVSCPLLNSCLSESPVVLQCTHVTPQRDKSVVCGSLFHTPKFVKGRQTPKHISESLGAEVDPDMSWSSSLATPPTLSSTVLIVRNEEASETVFPHDTTANVKSYFSNHDESLKKNDRFIASVTDSENTNQREAASHGFGKTSGNSFKVNSCKDHIGKSMPNVLEDEVYETVVDTSEEDSFSLCFSKCRTKNLQKVRTSKTRKKIFHEANADECEKSKNQVKEKYSFVSEVEPNDTDPLDSNVANQKPFESGSDKISKEVVPSLACEWSQLTLSGLNGAQMEKIPLLHISSCDQNISEKDLLDTENKRKKDFLTSENSLPRISSLPKSEKPLNEETVVNKRDEEQHLESHTDCILAVKQAISGTSPVASSFQGIKKSIFRIRESPKETFNASFSGHMTDPNFKKETEASESGLEIHTVCSQKEDSLCPNLIDNGSWPATTTQNSVALKNAGLISTLKKKTNKFIYAIHDETSYKGKKIPKDQKSELINCSAQFEANAFEAPLTFANADSGLLHSSVKRSCSQNDSEEPTLSLTSSFGTILRKCSRNETCSNNTVISQDLDYKEAKCNKEKLQLFITPEADSLSCLQEGQCENDPKSKKVSDIKEEVLAAACHPVQHSKVEYSDTDFQSQKSLLYDHENASTLILTPTSKDVLSNLVMISRGKESYKMSDKLKGNNYESDVELTKNIPMEKNQDVCALNENYKNVELLPPEKYMRVASPSRKVQFNQNTNLRVIQKNQEETTSISKITVNPDSEELFSDNENNFVFQVANERNNLALGNTKELHETDLTCVNEPIFKNSTMVLYGDTGDKQATQVSIKKDLVYVLAEENKNSVKQHIKMTLGQDLKSDISLNIDKIPEKNNDYMNKWAGLLGPISNHSFGGSFRTASNKEIKLSEHNIKKSKMFFKDIEEQYPTSLACVEIVNTLALDNQKKLSKPQSINTVSAHLQSSVVVSDCKNSHITPQMLFSKQDFNSNHNLTPSQKAEITELSTILEESGSQFEFTQFRKPSYILQKSTFEVPENQMTILKTTSEECRDADLHVIMNAPSIGQVDSSKQFEGTVEIKRKFAGLLKNDCNKSASGYLTDENEVGFRGFYSAHGTKLNVSTEALQKAVKLFSDIENISEETSAEVHPISLSSSKCHDSVVSMFKIENHNDKTVSEKNNKCQLILQNNIEMTTGTFVEEITENYKRNTENEDNKYTAASRNSHNLEFDGSDSSKNDTVCIHKDETDLLFTDQHNICLKLSGQFMKEGNTQIKEDLSDLTFLEVAKAQEACHGNTSNKEQLTATKTEQNIKDFETSDTFFQTASGKNISVAKESFNKIVNFFDQKPEELHNFSLNSELHSDIRKNKMDILSYEETDIVKHKILKESVPVGTGNQLVTFQGQPERDEKIKEPTLLGFHTASGKKVKIAKESLDKVKNLFDEKEQGTSEITSFSHQWAKTLKYREACKDLELACETIEITAAPKCKEMQNSLNNDKNLVSIETVVPPKLLSDNLCRQTENLKTSKSIFLKVKVHENVEKETAKSPATCYTNQSPYSVIENSALAFYTSCSRKTSVSQTSLLEAKKWLREGIFDGQPERINTADYVGNYLYENNSNSTIAENDKNHLSEKQDTYLSNSSMSNSYSYHSDEVYNDSGYLSKNKLDSGIEPVLKNVEDQKNTSFSKVISNVKDANAYPQTVNEDICVEELVTSSSPCKNKNAAIKLSISNSNNFEVGPPAFRIASGKIVCVSHETIKKVKDIFTDSFSKVIKENNENKSKICQTKIMAGCYEALDDSEDILHNSLDNDECSTHSHKVFADIQSEEILQHNQNMSGLEKVSKISPCDVSLETSDICKCSIGKLHKSVSSANTCGIFSTASGKSVQVSDASLQNARQVFSEIEDSTKQVFSKVLFKSNEHSDQLTREENTAIRTPEHLISQKGFSYNVVNSSAFSGFSTASGKQVSILESSLHKVKGVLEEFDLIRTEHSLHYSPTSRQNVSKILPRVDKRNPEHCVNSEMEKTCSKEFKLSNNLNVEGGSSENNHSIKVSPYLSQFQQDKQQLVLGTKVSLVENIHVLGKEQASPKNVKMEIGKTETFSDVPVKTNIEVCSTYSKDSENYFETEAVEIAKAFMEDDELTDSKLPSHATHSLFTCPENEEMVLSNSRIGKRRGEPLILVGEPSIKRNLLNEFDRIIENQEKSLKASKSTPDGTIKDRRLFMHHVSLEPITCVPFRTTKERQEIQNPNFTAPGQEFLSKSHLYEHLTLEKSSSNLAVSGHPFYQVSATRNEKMRHLITTGRPTKVFVPPFKTKSHFHRVEQCVRNINLEENRQKQNIDGHGSDDSKNKINDNEIHQFNKNNSNQAVAVTFTKCEEEPLDLITSLQNARDIQDMRIKKKQRQRVFPQPGSLYLAKTSTLPRISLKAAVGGQVPSACSHKQLYTYGVSKHCIKINSKNAESFQFHTEDYFGKESLWTGKGIQLADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISRIWVYNHYRWIIWKLAAMECAFPKEFANRCLSPERVLLQLKYRYDTEIDRSRRSAIKKIMERDDTAAKTLVLCVSDIISLSANISETSSNKTSSADTQKVAIIELTDGWYAVKAQLDPPLLAVLKNGRLTVGQKIILHGAELVGSPDACTPLEAPESLMLKISANSTRPARWYTKLGFFPDPRPFPLPLSSLFSDGGNVGCVDVIIQRAYPIQWMEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEEFEEHEENTTKPYLPSRALTRQQVRALQDGAELYEAVKNAADPAYLEGYFSEEQLRALNNHRQMLNDKKQAQIQLEIRKAMESAEQKEQGLSRDVTTVWKLRIVSYSKKEKDSVILSIWRPSSDLYSLLTEGKRYRIYHLATSKSKSKSERANIQLAATKKTQYQQLPVSDEILFQIYQPREPLHFSKFLDPDFQPSCSEVDLIGFVVSVVKKTGLAPFVYLSDECYNLLAIKFWIDLNEDIIKPHMLIAASNLQWRPESKSGLLTLFAGDFSVFSASPKEGHFQETFNKMKNTVENIDILCNEAENKLMHILHANDPKWSTPTKDCTSGPYTAQIIPGTGNKLLMSSPNCEIYYQSPLSLCMAKRKSVSTPVSAQMTSKSCKGEKEIDDQKNCKKRRALDFLSRLPLPPPVSPICTFVSPAAQKAFQPPRSCGTKYETPIKKKELNSPQMTPFKKFNEISLLESNSIADEELALINTQALLSGSTGEKQFISVSESTRTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNKQDTITTKKYI"},{"id":"SEQ_09891","a":"C4AMC7","g":"WASH3P","d":"Putative WAS protein family homolog 3","L":463,"m":[{"c":"Yψ[PA]DL[GP]","u":6,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Three closely spaced copies in the central proline/glycine-rich disordered region (residues 232-265, separated by 9-aa and 7-aa linkers) sharing invariant Y1, D4, and L5 anchors with strictly branched aliphatic ψ2 (V/L/I), [PA]3, and [GP]6.","i":[[232,237,"YVPDLG"],[247,252,"YLPDLP"],[260,265,"YIADLG"]]}],"s":"MTPVRMQHSLAGQTYAVPLIQPDLRREEAVQQMADALQYLQKVSGDIFSRISQQVEQSRSQVQAIGEKVSLAQAKIEKIKGSKKAIKVFSSAKYPAPERLQEYGSIFTGAQDPGLQRRPRHRIQSKHRPLDERALQEKDFPVCVSTKPEPEDDAEEGLGGLPSNISSVSSLLLFNTTENLGKKYVFLDPLAGAVTKTHVMLGAETEEKLFDAPLSISKREQLEQQVPENYFYVPDLGQVPEIDVPSYLPDLPGITNDLMYIADLGPGIAPSAPGTIPELPTFHTEVAEPLKVDLQDGVLTPPPPPPPPPPAPEVLASAPPLPPSTAAPVGQGARQDDSSSSASPSVQGAPREVVDPSGGRATLLESIRQAGGIGKAKLRSMKERKLEKKQQKEQEQVRATSQGGHLMSDLFNKLVMRRKGISGKGPGAGEGPGGAFARVSDSIPPLPPPQQPQAEEDEDDWES"},{"id":"SEQ_09899","a":"O95467","g":"GNAS","d":"Neuroendocrine secretory protein 55","L":245,"m":[{"c":"DΩETE[SP]ETx[SP]xxE[SP]ET","u":16,"sp":"tandem","x":"disordered_like","cf":"high","why":"Head-to-tail 16-residue tandem duplication (residues 108-139) in an acidic polar/proline-rich disordered region anchored by an N-terminal DΩ dipeptide (DY/DF), 9 identical positions across the 16-aa unit, and a concerted S-to-P swap across three internal positions.","i":[[108,123,"DYETESETESEIESET"],[124,139,"DFETEPETAPTTEPET"]]}],"s":"MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALATSNARAQQRAAAQQRRSFLNAHHRSGAQVFPESPESESDHEHEEADLELSLPECLEYEEEFDYETESETESEIESETDFETEPETAPTTEPETEPEDDRGPVVPKHSTFGQSLTQRLHALKLRSPDASPSRAPPSTQEPQSPREGEELKPEDKDPRDPEESKEPKEEKQRRRCKPKKPTRRDASPESPSKKGPIPIRRH"},{"id":"SEQ_09904","a":"Q9ULE0","g":"WWC3","d":"Protein WWC3","L":1216,"m":[{"c":"LPφGWExφxDxxxxVΩYψDHxo+xToφxDPR-","u":32,"sp":"dispersed","x":"structured_like","cf":"high","why":"Two highly conserved 32-residue structured repeats in the N-terminal region separated by a 17-residue linker, anchored by invariant LPxGWE, D, V[FY]Y[IM]DH, T, and C-terminal DPR[DE] motifs.","i":[[61,92,"LPAGWEEARDYDGRVFYIDHNTRQTSWIDPRD"],[108,139,"LPLGWETVYDKQIGVYYMDHINKLTQIEDPRE"]]},{"c":"[GA]SSRGSL","u":7,"sp":"tandem","x":"disordered_like","cf":"high","why":"Three head-to-tail tandem 7-residue copies within a central serine/proline-rich disordered linker sharing an invariant SSRGSL core with fixed basic (R), glycine (G), and hydrophobic leucine (L) anchors.","i":[[490,496,"GSSRGSL"],[497,503,"ASSRGSL"],[504,510,"ASSRGSL"]]}],"s":"MPWLSGGRRRRRGQPREAPREPPPSAQPQREPPPAPPAAVPTPPAPSAPPPRARESAELPLPAGWEEARDYDGRVFYIDHNTRQTSWIDPRDRITKPLTFADCVGDELPLGWETVYDKQIGVYYMDHINKLTQIEDPREQWRREQERMLKEYLIVAQEALNAKKEIYQIKQQRFELAQEEYQQLHKMCEDDSRSYASSFSGYSTNTKYDPHQIKAEIASRRDRLSRLKRELTQMKQELQYKEKGVETLQEIDRKMSSTHTSYKLDEAQAIMSELRTIKKAICTGEKERRDLMHSLAKLTDSFKNSCSVTDSLVDFPHHVGVPGDAGVPQQFCDAGSQTDIIGEFVFDDKTRLVDRVRLNWQYEEARKRVANIQQQLARLDNESWPSTAEADRDRLQLIKEKEALLQELQLIIAQRRSAGDVARLEEERERLEEELRRARATSAQGATERILLQEKRNCLLMQLEEATRLTSYLQSQLKSLCASTLTVSSGSSRGSLASSRGSLASSRGSLSSVSFTDIYGLPQYEKPDAEGSQLLRFDLIPFDSLGRDAPFSEPPGPSGFHKQRRSLDTPQSLASLSSRSSLSSLSPPSSPLDTPFLPASRDSPLAQLADSCEGPGLGALDRLRAHASAMGDEDLPGMAALQPHGVPGDGEGPHERGPPPASAPVGGTVTLREDSAKRLERRARRISACLSDYSLASDSGVFEPLTKRNEDAEEPAYGDTASNGDPQIHVGLLRDSGSECLLVHVLQLKNPAGLAVKEDCKVHIRVYLPPLDSGTPNTYCSKALEFQVPLVFNEVFRIPVHSSALTLKSLQLYVCSVTPQLQEELLGIAQINLADYDSLSEMQLRWHSVQVFTSSEPSRTREAGCAGESSARDPAHTISISGKTDAVTVLLARTTAQLQAVERELAEERAKLEYTEEEVLEMERKEEQAEAISERSWQADSVDSGCSNCTQTSPPYPEPCCMGIDSILGHPFAAQAGPYSPEKFQPSPLKVDKETNTEDLFLEEAASLVKERPSRRARGSPFVRSGTIVRSQTFSPGARSQYVCRLYRSDSDSSTLPRKSPFVRNTLERRTLRYKQSCRSSLAELMARTSLDLELDLQASRTRQRQLNEELCALRELRQRLEDAQLRGQTDLPPWVLRDERLRGLLREAERQTRQTKLDYRHEQAAEKMLKKASKEIYQLRGQSHKEPIQVQTFREKIAFFTRPRINIPPLPADDV"},{"id":"SEQ_09909","a":"Q9Y4X4","g":"KLF12","d":"Krueppel-like factor 12","L":402,"m":[{"c":"[HYF]+C(x){2,4}Cxxx[FY][AST]+S[DS][EH]LxxH[RY]R[KRT]H","u":"23-25","sp":"periodic","x":"structured_like","cf":"high","why":"Three C-terminal Cys2-His2-type repeats separated by regular 5-residue TG[EV]KP linkers, anchored by invariant C-x(2,4)-C and H-x(3)-H coordination pairs plus conserved [HYF]+, aromatic [FY], S, L, and R positions.","i":[[317,341,"HRCDFEGCNKVYTKSSHLKAHRRTH"],[347,371,"YKCTWEGCTWKFARSDELTRHYRKH"],[377,399,"FKCADCDRSFSRSDHLALHRRRH"]]}],"s":"MNIHMKRKTIKNINTFENRMLMLDGMPAVRVKTELLESEQGSPNVHNYPDMEAVPLLLNNVKGEPPEDSLSVDHFQTQTEPVDLSINKARTSPTAVSSSPVSMTASASSPSSTSTSSSSSSRLASSPTVITSVSSASSSSTVLTPGPLVASASGVGGQQFLHIIHPVPPSSPMNLQSNKLSHVHRIPVVVQSVPVVYTAVRSPGNVNNTIVVPLLEDGRGHGKAQMDPRGLSPRQSKSDSDDDDLPNVTLDSVNETGSTALSIARAVQEVHPSPVSRVRGNRMNNQKFPCSISPFSIESTRRQRRSESPDSRKRRIHRCDFEGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHYRKHTGVKPFKCADCDRSFSRSDHLALHRRRHMLV"},{"id":"SEQ_09915","a":"Q9NQ76","g":"MEPE","d":"Matrix extracellular phosphoglycoprotein","L":525,"m":[{"c":"[FY][KN]-[IL]P[EGK][KRN][EG]","u":8,"sp":"dispersed","x":"disordered_like","cf":"high","why":"Four dispersed 8-residue motifs embedded in the central hydrophilic/disordered region (spaced by 34-39 aa linkers), anchored by an N-terminal aromatic [FY], [KN], acidic D/E, aliphatic [IL], invariant P, and C-terminal [EG].","i":[[262,269,"FKDIPGKG"],[303,310,"YNEIPERE"],[347,354,"FKELPGRE"],[396,403,"YNEIPKNG"]]}],"s":"MRVFCVGLLLFSVTWAAPTFQPQTEKTKQSCVEEQRQEEKNKDNIGFHHLGKRINQELSSKENIVQERKKDLSLSEASENKGSSKSQNYFTNRQRLNKEYSISNKENTHNGLRMSIYPKSTGNKGFEDGDDAISKLHDQEEYGAALIRNNMQHIMGPVTAIKLLGEENKENTPRNVLNIIPASMNYAKAHSKDKKKPQRDSQAQKSPVKSKSTHRIQHNIDYLKHLSKVKKIPSDFEGSGYTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAESTHLDTKKPGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNRVDAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVDHSNRNQATLNEKQRFPSKGKSQGLPIPSRGLDNEIKNEMDSFNGPSHENIITHGRKYHYVPHRQNNSTRNKGMPQGKGSWGRQPHSNRRFSSRRRDDSSESSDSGSSSESDGD"},{"id":"SEQ_09922","a":"B1AJZ9","g":"FHAD1","d":"Forkhead-associated domain-containing protein 1","L":1412,"m":[{"c":"φ[LS][EA]xxI[TA]xE+[NR]+[AV]KE[AT][LM]ExE[KRQ][KRT]+[VM]Q-LE[ENS]xL[AT][KQR]QK[EK]","u":36,"sp":"tandem","x":"structured_like","cf":"high","why":"Four head-to-tail tandem 36-aa helical repeats (residues 689-832) exhibiting strong sequence identity across the entire unit, anchored by invariant I6, E9, K14, E15, E18, E20, Q25, L27, E28, L31, Q34, and K35 alongside conserved basic and hydrophobic positions.","i":[[689,724,"ALEEYITQERNRAKETLEEERKRMQELESLLAQQKK"],[725,760,"ALAKSITQEKNRVKEALEEEQTRVQELEERLARQKE"],[761,796,"VLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKE"],[797,832,"ISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKE"]]}],"s":"MKAYLKSAEGFFVLNKSTTIGRHENSDLVLQSPDIDNHHALIEYNEAECSFVLQDFNSRNGTFVNECHIQNVAVKLIPGDILRFGSAGLTYELVIENPPPVSFPWMRGPAPWPGPQPPRATQQPNQAPPPSHIPFHQGVQPAPMQRSWSQAFPRPTVVLPASHRRPVSANKEMFSFVVDDARKPPVIKQVWTNAMKLSEKSVAEGIPGAVPPAEIYVEEDLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSLLHSKPSGKY"},{"id":"SEQ_09952","a":"O43157","g":"PLXNB1","d":"Plexin-B1","L":2135,"m":[{"c":"C(x){5,11}CxxC(x){6,8}CxWC(x){5,6}Cxx+xxC","u":"33-38","sp":"dispersed","x":"structured_like","cf":"high","why":"Three dispersed copies of a cysteine-rich domain sharing seven invariant cysteines in a fixed disulfide-like register, an invariant tryptophan in the CxWC core, and a conserved basic residue in the C-terminal Cxx+xxC segment.","i":[[482,514,"CAQHLDCASCLAHRDPYCGWCVLLGRCSRRSEC"],[629,666,"CVAVTELRPSAQCQACVSSRWGCNWCVWQHLCTHKASC"],[1022,1057,"CSVGHGDCSRCQTAMPQYGCVWCEGERPRCVTREAC"]]},{"c":"[GP]GxxφxψxGx[NK]L(x){9,10}V[TVA][VM](x){3,36}PC(x){9,14}C","u":"42-72","sp":"periodic","x":"structured_like","cf":"high","why":"Four regularly spaced domain cores following the third cysteine-rich repeat, anchored by an N-terminal [GP]GxxφxψxGx[NK]L beta-strand motif, an internal V[TVA][VM] hydrophobic triplet, and a conserved C-terminal PC(x){9,14}C pair (with a 33-residue loop insertion in the third copy).","i":[[1084,1128,"GGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVC"],[1176,1217,"GGTRLTLNGSKLLTGRLEDIRVVVGDQPCHLLPEQQSEQLRC"],[1266,1337,"GGREICVRGQNLDVVQTPRIRVTVVSRMLQPSQGLGRRRRVVPETACSLGPSCSSQQFEEPCHVNSSQLITC"],[1396,1437,"PGSVFSVEGENLDLAMSKEEVVAMIGDGPCVVKTLTRHHLYC"]]}],"s":"MPALGPALLQALWAGWVLTLQPLPPTAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQAQPTNNPNQLLLVSPGALVVCGSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTSRGVGGGIPPITTRALWPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDLQAQSRAFRAYVSRVCLRDQHYYSYVELPLACEGGRYGLIQAAAVATSREVAHGEVLFAAFSSAAPPTVGRPPSAAAGASGASALCAFPLDEVDRLANRTRDACYTREGRAEDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEATPILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVASCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSRGQGPEQWLWSFQPELGCLQVAAMSPANISREETREVFLSVPDLPPLWPGESYSCHFGEHQSPALLTGSGVMCPSPDPSEAPVLPRGADYVSVSVELRFGAVVIAKTSLSFYDCVAVTELRPSAQCQACVSSRWGCNWCVWQHLCTHKASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPWGPWAGSGSISSPGSTGSPLHEEPSPPSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADPGPEALHPTVPLDLPPATVPATTFPGAMGSVKPALDWLTREGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEGPPAPLILPSSLDYQYDTPGLWELEEATLGASSCPCVESVQGSTLMPVHVEREIRLLGRNLHLFQDGPGDNECVMELEGLEVVVEARVECEPPPDTQCHVTCQQHQLSYEALQPELRVGLFLRRAGRLRVDSAEGLHVVLYDCSVGHGDCSRCQTAMPQYGCVWCEGERPRCVTREACGEAEAVATQCPAPLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGASGEEVAGATAVEVPGRGRGVSEHDFAYQDPKVHSIFPARGPRAGGTRLTLNGSKLLTGRLEDIRVVVGDQPCHLLPEQQSEQLRCETSPRPTPATLPVAVWFGATERRLQRGQFKYTLDPNITSAGPTKSFLSGGREICVRGQNLDVVQTPRIRVTVVSRMLQPSQGLGRRRRVVPETACSLGPSCSSQQFEEPCHVNSSQLITCRTPALPGLPEDPWVRVEFILDNLVFDFATLNPTPFSYEADPTLQPLNPEDPTMPFRHKPGSVFSVEGENLDLAMSKEEVVAMIGDGPCVVKTLTRHHLYCEPPVEQPLPRHHALREAPDSLPEFTVQMGNLRFSLGHVQYDGESPGAFPVAAQVGLGVGTSLLALGVIIIVLMYRRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDLTSDLLGSGIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGPGAGEAQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDPRTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPCLTKHVLRENQDYVPGERTPMLEDVDEGGIRPWHLVKPSDEPEPPRPRRGSLRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKMQLGYRLQQIAAAVENKVTDL"},{"id":"SEQ_09966","a":"Q96ST2","g":"IWS1","d":"Protein IWS1 homolog","L":819,"m":[{"c":"xSDSEoE-xx+xx","u":13,"sp":"tandem","x":"disordered_like","cf":"high","why":"18-copy tandem 13-mer array (residues 79-324, interrupted once by a 12-aa 1-residue-short copy ASDSENEDVNQH) in an acidic/proline-rich disordered region. Anchored by an invariant SDSE core and Glu7, polar uncharged S/N/T at position 6, acidic E/D at position 8, and a conserved basic K/R anchor at position 11 often flanked by Pro and His/Gln/Arg.","i":[[79,91,"ASDSESEELHRQK"],[92,104,"DSDSESEERAEPP"],[117,129,"GSDSESEETRKLP"],[130,142,"GSDSENEELLNGH"],[143,155,"ASDSENEDVGKHP"],[156,168,"ASDSEIEELQKSP"],[169,181,"ASDSETEDALKPQ"],[182,194,"ISDSESEEPPRHQ"],[195,207,"ASDSENEEPPKPR"],[208,220,"MSDSESEELPKPQ"],[221,233,"VSDSESEEPPRHQ"],[234,246,"ASDSENEELPKPR"],[247,259,"ISDSESEDPPRHQ"],[260,272,"ASDSENEELPKPR"],[273,285,"ISDSESEDPPRNQ"],[286,298,"ASDSENEELPKPR"],[299,311,"VSDSESEGPQKGP"],[312,324,"ASDSETEDASRHK"]]}],"s":"MDSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPAVVMHLKKQDLKETFIDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQELPSVSQETLKHSGIGRAVMYLYKHPKESRSNKDMAGKLINEWSRPIFGLTSNYKGMTREEREQRDLEQMPQRRRMNSTGGQTPRRDLEKVLTGEEKALRPGDPGFCARARVPMPSNKDYVVRPKWNVEMESSRFQATSKKGISRLDKQMRKFTDIRKKSRSAHAVKISIEGNKMPL"},{"id":"SEQ_09987","a":"Q6IE81","g":"JADE1","d":"Protein Jade-1","L":842,"m":[{"c":"ψVCxψC(x){9,13}C(x){2,4}CxxxφHx[AT]Cφ(x){11,22}Cxx[CH]","u":"47-56","sp":"dispersed","x":"structured_like","cf":"medium","why":"Two cysteine/histidine-rich structured repeats (residues 204-250 and 313-368, separated by a 62-aa linker) sharing a conserved 4-pair C/H coordination architecture anchored by N-terminal ψVCxψC, C(x){2,4}C followed by a 4-residue spacer ending in φ before Hx[AT]Cφ, and C-terminal Cxx[CH].","i":[[204,250,"VVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTC"],[313,368,"LVCSLCNEKFGASIQCSVKNCRTAFHVTCAFDRGLEMKTILAENDEVKFKSYCPKH"]]}],"s":"MKRGRLPSSSEDSDDNGSLSTTWSQNSRSQHRRSSCSRHEDRKPSEVFRTDLITAMKLHDSYQLNPDEYYVLADPWRQEWEKGVQVPVSPGTIPQPVARVVSEEKSLMFIRPKKYIVSSGSEPPELGYVDIRTLADSVCRYDLNDMDAAWLELTNEEFKEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEEGLGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQPKCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNEKFGASIQCSVKNCRTAFHVTCAFDRGLEMKTILAENDEVKFKSYCPKHSSHRKPEESLGKGAAQENGAPECSPRNPLEPFASLEQNREEAHRVSVRKQKLQQLEDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKVNFNKPLITPKKDEEDNLAKREQDVLFRRLQLFTHLRQDLERVRNLTYMVTRREKIKRSVCKVQEQIFNLYTKLLEQERVSGVPSSCSSSSLENMLLFNSPSVGPDAPKIEDLKWHSAFFRKQMGTSLVHSLKKPHKRDPLQNSPGSEGKTLLKQPDLCGRREGMVVPESFLGLEKTFAEARLISAQQKNGVVMPDHGKRRDNRFHCDLIKGDLKDKSFKQSHKPLRSTDVSQRHLDNTRAATSPGVGQSAPGTRKEIVPKCNGSLIKVNYNQTAVKVPTTPASPVKNWGGFRIPKKGERQQQGEAHDGACHQHSDYPYLGLGRVPAKERAKSKLKSDNENDGYVPDVEMSDSESEASEKKCIHTSSTISRRTDIIRRSILAS"},{"id":"SEQ_09993","a":"Q5VWK0","g":"NBPF6","d":"NBPF family member NBPF6","L":638,"m":[{"c":"DxE[EV]xxxQ[ES]x[PV][AC]PRx[SV][QR](x){5,8}EψP[QE]-Sψ[DEN][EG][CV]xψT[CP]Sxx[HP][DN]x[ST]x[SC]x[HQ]P[HY]xST[KL]x[ST][FL]x-xx[AV]x[SL]AL[DV][DV]","u":"67-70","sp":"dispersed","x":"mixed","cf":"high","why":"Three complete 67-70 aa repeats (with an additional internally truncated remnant at residues 268-308 lacking the central segment) share three tightly conserved blocks: an N-terminal DxE[EV]xxxQ..PR motif, a central EψP[QE]-Sψ..ψT[CP]S motif after a 5-8 aa loop, and a C-terminal [HQ]P[HY]xST[KL]..AL[DV][DV] amphipathic segment, separated by variable linkers (85 aa and 4 aa).","i":[[178,244,"DEEVEKVQESPAPREVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFKEHEVDSALVV"],[330,399,"DLEEVKGQETVAPRLSRGPLRVDKHEIPQESLDGCCLTPSILPDLTPSYHPYWSTLYSFEDKQVSLALVD"],[404,473,"DQEEIEDQSPPCPRLSQELPEVKEQEVPEDSVNEVYLTPSVHHDVSDCHQPYSSTLSSLEDQLACSALDV"]]}],"s":"MVVSADPLSSERAEMNILEINQELRSQLAESNQQFRDLKEKFLITQATAYSLANQLKKYKCEEYKDIIDSVLRDELQSMEKLAEKLRQAEELRQYKALVHSQAKELTQLREKLREGRDASRWLNKHLKTLLTPDDPDKSQGQDLREQLAEGHRLAEHLVHKLSPENDEDEDEDEDDKDEEVEKVQESPAPREVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFKEHEVDSALVVESEHPHDEEEEALNIPPENQNDHEEEEGKAPVPPRHHDKSNSYRHREVSFLALDEQKVCSAQDVARDYSNPKWDETSLGFLEKQSDLEEVKGQETVAPRLSRGPLRVDKHEIPQESLDGCCLTPSILPDLTPSYHPYWSTLYSFEDKQVSLALVDKIKKDQEEIEDQSPPCPRLSQELPEVKEQEVPEDSVNEVYLTPSVHHDVSDCHQPYSSTLSSLEDQLACSALDVASPTEAACPQGTWSGDLSHHRSEVQISQAQLEPSTLVPSCLRLQLDQGFHCGNGLAQRGLSSTTCSFSANADSGNQWPFQELVLEPSLGMKNPPQLEDDALEGSASNTQGRQVTGRIRASLVLILKTIRRRLPFSKWRLAFRFAGPHAESAEIPNTAERMQRMIG"},{"id":"SEQ_09994","a":"P11388","g":"TOP2A","d":"DNA topoisomerase 2-alpha","L":1531,"m":[{"c":"[DSE][DES][DES][DNL]F","u":5,"sp":"dispersed","x":"disordered_like","cf":"medium","why":"Six dispersed copies in the C-terminal disordered tail (residues 1304-1531) pair an acidic/serine-rich N-terminal tripeptide with a constrained [DNL] position and an invariant C-terminal phenylalanine anchor.","i":[[1304,1308,"DESNF"],[1332,1336,"SDEDF"],[1344,1348,"DDEDF"],[1474,1478,"SDSNF"],[1494,1498,"ESDDF"],[1527,1531,"EDDLF"]]}],"s":"MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDDLF"},{"id":"SEQ_09999","a":"Q9Y5I0","g":"PCDHA13","d":"Protocadherin alpha-13","L":950,"m":[{"c":"(x){19,30}[AV]xDx[DG](x){34,39}ψDx[EV](x){6,12}φx[VL]x[AV](x){0,1}D(x){7,11}[VL]xψxψx-x[NG][DQ][NA][AP][PQ]xx","u":"104-114","sp":"tandem","x":"structured_like","cf":"high","why":"Six head-to-tail 104-114 aa structured repeats spanning residues 30-679 with conserved [AV]xDx[DG], central ψDx[EV], φx[VL]x[AV](x){0,1}D, and C-terminal [VL]xψxψx followed by a D[IVE]NDN[AP]Pxφ signature in copies 1-5 (diverged to ESGQAPQAS in copy 6).","i":[[30,133,"QLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVKVRDINDNPPIF"],[134,242,"PESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYFTLDAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEF"],[243,350,"YQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTINPNNGEIRTKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEV"],[351,455,"TITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNAPAF"],[456,565,"AQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPAL"],[566,679,"LTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFRVGLYTGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTATATVLLSLVESGQAPQAS"]]}],"s":"MLSSWQGGPRPRQLLLWLLILAAWETGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVKVRDINDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYFTLDAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTINPNNGEIRTKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFRVGLYTGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTATATVLLSLVESGQAPQASSRASAGAVGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAPPTEGACAPGKPTLVCSSAAGSWSYSQQRRPRVCSGEGPHKTDLMAFSPSLPPCLGSAEGTGQREEDSECLKEPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ"},{"id":"SEQ_10010","a":"Q9P219","g":"CCDC88C","d":"Protein Daple","L":2028,"m":[{"c":"[TS]AxYEALψxxHxxLxTLHxxx","u":21,"sp":"tandem","x":"structured_like","cf":"medium","why":"Head-to-tail 21-aa (three-heptad) internal duplication within the alpha-helical rod sharing 10 identical anchors (including Y, two H residues, T, A, E, and L) plus a conserved aliphatic position across an 18-aa core.","i":[[1161,1181,"TAAYEALLQDHEHLGTLHERQ"],[1182,1202,"SAEYEALIRQHSCLKTLHRNL"]]},{"c":"LxxxNxTφSSQxφxLoxQxxφLQxHxTxxxTxo","u":33,"sp":"tandem","x":"structured_like","cf":"medium","why":"Tandem 33-aa duplication (separated by a 2-aa AK linker) immediately upstream of the 21-aa tandem pair, anchored by 13 identical residues (including NxTφSSQ and φLQxHxT motifs) and 5 physicochemically conserved positions.","i":[[1083,1115,"LETQNVTFSSQILTLQKQSAFLQEHNTTLQTQT"],[1118,1150,"LQVENSTLSSQSAALTAQYTLLQNHHTAKETEN"]]}],"s":"MDVTVSELLELFLQSPLVTWVKTFGPFGSGSQDNLTMYMDLVDGIFLNQIMLQIDPRPTNQRINKHVNNDVNLRIQNLTILVRNIKTYYQEVLQQLIVMNLPNVLMIGRDPLSGKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPDVAPEELEALSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSPPWQLESSDPASPAASQPLRSQAENPDTPALGSNCAEERDAHNGSVGKGPGDLKPKRGSPHRGSLDRTDASTDLAMRSWPSELGSRTCSTSATTTAPSNSTPIARHPGRTKGYNSDDNLCEPSLEFEVPNHRQYVSRPSSLESSRNTSSNSSPLNLKGSSEQLHGRSESFSSEDLIPSRDLATLPREASTPGRNALGRHEYPLPRNGPLPQEGAQKRGTAPPYVGVRPCSASPSSEMVTLEEFLEESNRSSPTHDTPSCRDDLLSDYFRKASDPPAIGGQPGPPAKKEGAKMPTNFVAPTVKMAAPTSEGRPLKPGQYVKPNFRLTEAEAPPSVAPRQAQPPQSLSLGRPRQAPVPPASHAPASRSASLSRAFSLASADLLRASGPEACKQESPQKLGAPEALGGRETGSHTLQSPAPPSSHSLARERTPLVGKAGSSCQGPGPRSRPLDTRRFSLAPPKEERLAPLHQSATAPAIATAGAGAAAAGSGSNSQLLHFSPAAAPAARTKPKAPPRSGEVATITPVRAGLSLSEGDGVPGQGCSEGLPAKSPGRSPDLAPHLGRALEDCSRGSVSKSSPASPEPGGDPQTVWYEYGCV"}]